Prof. dr. J.P. Medema
| Title | Prof. dr. | |
| Initials | J.P. | |
| Surname | Medema | |
| First name | J. P. | |
| E-mail address | J.P. Medema | |
| Position | Professor | |
| Main activities | Research | |
| Specialisation | Medical Biology/Oncology/Immunology |
J.P. Medema is one of the AMC Principal Investigators.
Focus of research
| AMC themes | Infection & Immunity; Oncology. |
| Departments | Center of Experimental and Molecular Medicine (CEMM). |
Key publications
- Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH, Peter ME, FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO JOURNAL 16 (10), 1997, p.2794-2804
- Vermeulen L, Todaro M, Mello FDS, Sprick MR , Kemper K, Alea MP, Richel DJ, Stassi G, Medema JP, Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 (36), 2008, p.13427-13432
- Medema JP, de Jong J, Peltenburg LT, Verdegaal EM, Gorter A, Bres SA, Franken KL, Hahne M, Albar JP, Melief CJ, Offringa R, Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98 (20), 2001, p.11515-11520
- Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, Iovino F, Tripodo C, Russo A, Gulotta G, Medema JP, Stassi G, Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. CELL STEM CELL 1 (4), 2007, p.389-402
- Planelles L, Carvalho-Pinto CE, Hardenberg G, Smaniotto S, Savino W, Gómez-Caro R, Alvarez-Mon M, de Jong J, Eldering E, Martínez-A C, Medema JP, Hahne M, APRIL promotes B-1 cell-associated neoplasm. CANCER CELL 6 (4), 2004, p.399-408
Research programmes
Prof. dr. J.P. Medema - Cell death induction and resistance in tumor cellsJan Paul Medema is heading the Laboratory of EXperimental Oncology and Radiobiology or LEXOR. His laboratory has developed several research lines that all focus on a central theme, which is the mechanisms of survival/cell death resistance of tumor cells against therapeutic interventions. The research lines roughly fall into three catagories.
1. Survival and Death signalling by members of the TNF family. This mainly involves the role of APRIL and TRAIL on cell death in oncological settings as well as physiological immune responses. APRIl is a factor that is expressed in a wide range of tumor cells and appears to enhance their tumorigenicity. We are studying the mechanism behind this potentiation as well as means to prevent it for therapeutic purposes. TRAIL on the other hand rather induces death in tumor cells. In the laboratory we try to understand what the physiological role for this molecule is and how it regulates immune responses.
2. Cancer stem cells. We have shown that this specific subset of cancer cells can reconstitute a complete tumour even when a single cell is used. Moreover, we found that they specifically protect themseleves against therapy when using IL-4. We aim to understand these cell death mechanisms better. In addition, we would like to define the plasticity of these cells and gain insight into the signals that maintain the tumor initiating properties of these cells.
3. Novel therapeutic avenues. Radiation therapy can effectively kill cancer cells, but improvement of its efficacy is still greatly needed. Similarly, chemotherapy even in combination with radiotherapy is only effective in a subset of the cancer patients. In the laboratory, we try to optimize combination trreatments based on molecular insights of tumors. Pathway inhibition combined with novel drugs or different dosing schemes is evaluated in tissue culture and in vivo models in order to enhance therapeutic efficacy.
Themes: Oncology and Infection and Immunity
| Faculty | Postdocs | PhD students | Others |
|---|---|---|---|
|
Prof. dr.
J.P. Medema
(Leader)
Dr. N.A.P. Franken |
Dr.
A.C.
Grandela
Dr. F.C. Kimberley M.C. Wolkers PhD |
M.
Balzarolo
T. Borovski S. Colak M. Guadagnoli S.E. Hovingh K. Kemper V. Lascano Drs. F. Mullauer L. Potze F. de Sousa Mello L. Vermeulen |
S.P.
van den Bergh
K. Cameron R. ten Cate J. de Jong H.M. Rodermond |
Other research related activities
- Membership of editorial board / Editorship, CELL DEATH AND DIFFERENTIATION
- Membership of advisory board / Consultant, Apogenix GmbH
Current research funding
None reported.
Last updated on: 25/01/2010
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