Prof. dr. P.P. Tak
| Title | Prof. dr. |
|
| Initials | P.P. | |
| Surname | Tak | |
| First name | P. P. | |
| E-mail address | P.P. Tak | |
| Position | ||
| Main activities | Patient care, Research, Teaching | |
| Specialisation |
P.P. Tak is one of the AMC Principal Investigators.
Focus of research
This research program focuses on the research line “ the pathogenesis of rheumatic disease and development of innovative therapies” which encompasses a multidisciplinary approach to get more insight into the inflammatory processes that are involved in various stages of rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis, Sjögren’s disease, and SLE and to translate this knowledge into novel therapeutic approaches, including gene therapy and targeted therapies using biologicals and targeted small molecules. Prof. Tak's group has extensive experience in immunohistochemistry, digital image analysis, intracellular signaling, T cell receptor analysis, in vitro and ex vivo models, animal model of arthritis, gene therapy, and biological treatment.
| AMC themes | Infection & Immunity. |
| Departments | Internal Medicine: Clinical Immunology/Rheumatology. |
Key publications
- Vos K, Thurlings RM, Wijbrandts CA, van Schaardenburg D, Gerlag DM, Tak PP, Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis. ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH 56 (3), 2007, p.772-778
- Tracey D, Klareskog L, Sasso EH, Salfeld JG, Tak PP, Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. PHARMACOLOGY & THERAPEUTICS 117 (2), 2008, p.244-279
- van Maanen MA, Lebre MC, van der Poll T, Larosa GJ, Elbaum D, Vervoordeldonk MJ, Tak PP, Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH 60 (1), 2009, p.114-122
- Tas SW, Vervoordeldonk MJ, Hajji N, Schuitemaker JHN, van der Sluijs KF, May MJ, Ghosh S, Kapsenberg ML, Tak PP, de Jong EC, Noncanonical NF-kappa B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. BLOOD 110 (5), 2007, p.1540-1549
- van Maanen MA, Stoof SP, van der Zanden EP, de Jonge WJ, Janssen RA, Fischer DF, Vandeghinste N, Brys R, Vervoordeldonk MJ, Tak PP, The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation. ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH 60 (5), 2009, p.1272-1281
Research programmes
Prof. dr. P.P. Tak - The pathogenesis of rheumatic disease and development of innovative therapiesThis program has focused on rheumatoid arthritis (RA), psoriatic arthritis (PsA), and Sjögren’s syndrome (SS); we aim to translate new discoveries into novel therapeutic approaches. We have continued a large program called ‘Synoviomics’, which aims at identifying genes and proteins involved in the pathogenesis of various arthritides using microarray technology.
The potential of chemokine blockade has been explored in in vitro models of migration and in phase Ib/II proof of concept studies. Changes in serial synovial biopsy samples are used as biomarkers to predict possible clinical efficacy and to provide insight into the mechanism of action of therapy. Similarly, studies have been performed to provide more insight into the mechanism of action of anti-TNF and rituximab treatment in RA patients and to identify markers that might be used to predict clinical efficacy.
For the development of gene therapy we have continued to work on the development of novels AAV-constructs. We have submitted a patent on a discovery in this field and aim at further development for treatment of RA and SS.
We have developed new approaches for the analysis of T cell receptor (TCR) repertoires, in close collaboration with AMC’s Dept. of Neurogenetics; we have submitted a patent application.
Theme: Infection and Immunity
| Faculty | Postdocs | PhD students | Others |
|---|---|---|---|
|
Prof. dr.
P.P. Tak
(Leader)
Dr. D.M. Gerlag Dr. N. de Vries |
L.G.M.
van Baarsen
PhD
Dr. R.J. Bisoendial Dr. M.C. Lebre Dr. S.W. Tas |
Drs.
C.J.
Aalbers
(Arthrogen)
Drs. C. Ambarus MD M.J.H. Boumans MD Y.K. Choi MD Drs. M.E. Doorenspleet A.M. Grabiec BSc D. Greven MD M.J. de Hair MD M. Herenius MD R. Klaasen MD P.L. Klarenbeek MD F.A. Koopman MD Drs. E.N. Kop MD S. Krausz MD K.I. Maijer MD Drs. A.R. Noort Drs. J.E.P. Paramarta MD M.I. Pascoal Martins Ramos BSc G.F. Salinas BSc M.G. van de Sande MD Drs. R.M. Thurlings Drs. C.E. Vergunst Drs. J.L. Vosters |
Other research related activities
more...
- Board of directors / Trustees / Supervisory board, Heliomare
- Board of directors / Trustees / Supervisory board, Arthrogen B.V.
- Board of directors / Trustees / Supervisory board, Institute for Innovative Therapies
- Membership of medical or scientific committee, ZonMw (Netherlands Organisation for Health Research and Development)
- Membership of medical or scientific committee, Executive Committee, European League against Rheumatism
- Membership of medical or scientific committee, Chairman, Grant Advisory Counsil, European League Against Rheumatism
- Membership of medical or scientific committee, Scientific Committee, European League against Rheumatism
- Membership of medical or scientific committee, Annual Meeting Planning Commitee, American College of Rheumatology
- Membership of editorial board / Editorship, ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
- Membership of editorial board / Editorship, ANNALS OF THE RHEUMATIC DISEASES
Current research funding
- CTMM
- Karolinska Institutet Fakturor
- Koningin Wilhelmina Fonds
- MC Grilo Mesquita Lebre
- Reumafonds
- Senter Den Haag
- Slotervaartziekenhuis
- St.Inst. Innovative Therapies
- Stichting MS Research
- ZonMw
Last updated on: 31/03/2010
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