Mouse Morphology, Genetics & Function

Goal:

Animal experiments, especially using mice and rats, are an important part of many PhD projects. A better understanding of rodent anatomy, histology, pathology, genetics, wellbeing, and a proper perspective of the difference of rodent models versus human physiology can improve the quality of these experiments substantially.

Course participants are introduced into various aspects of research with rodents. The aim is to increase awareness of the physiology and genetics of experimental animals thereby enabling better planning and execution of animal research.

After finishing this course students:

· Can describe and demonstrate the anatomy and histology of major organs of the mouse.

· Are able to choose mouse strains suitable for their research.

· Can interpret histological and imaging data.

· Can judge behavior and deduce wellbeing of experimental animals

· Can design mouse experiments that are better suited for translation to humans.


Format:

This course is organized and coordinated by the Tytgat Institute for Liver & Intestinal Research and the Department of Medical Biology, in collaboration with the Oncology Graduate School of Amsterdam (OOA, Onderzoekschool Oncologie Amsterdam). The course is incorporated in the course program of the AMC Graduate School for Medical Sciences. Participants follow lectures in the morning and learn hands-on skills in the afternoon.

The course lasts 5 days and takes place once a year.

Content:
The subjects covered are:

1. Anatomy (dissection) of adult male and female mice
2. Microscopic and pathological anatomy of rodent tissues and organs
3. Dealing with pathologically changed animals
4. Developmental anatomy; comparison of rodent and human anatomy
5. Imaging the mouse (MRI)
6. Gene targeting, transgenic strategies, and generation of mouse models-1
7. Gene targeting, transgenic strategies, and generation of mouse models-2
8. Mouse breeding and querying the Jax phenotype database
9. Rodent behavior and experimental outcomes

Scheduled dates:
9 thru 13 April, 2018

Target audience:
PhD candidates, postdocs and technicians are also welcome.

Language:
English

Study load:
40 hours, which is comparable to 1.5 ECTS points.

Number of participants:
Maximum 28 per course.

Costs:
Free of charge.

Course coordinators:
Dr. J.E. Seppen / Tytgat Institute for Liver and Intestinal Research / j.seppen@amc.uva.nl / tel. +31 (0)20 566 5405

Prof.dr. V.M. Christoffels / Dept. Medical Biology / v.m.christoffels@amc.uva.nl / tel. +31 (20) 566 7821

Application:
Via the Tytgat Institute; Ms Mona Brox Edvardsen / Tytgat Institute for Liver and Intestinal Research / m.edvardsen@amc.uva.nl / tel. +31 (0)20 566 5948

More information:
From the coordinators or M. Brox Edvardsen: m.edvardsen@amc.uva.nl.

Contact

AMC Graduate School
E-mail
Tel: +31 (0)20 - 5663108