Clinical Hematology

The department of Clinical Hematology has four main research lines:

  1. Pathogenesis and (immuno)therapy of B cell malignancies, with a strong focus on Chronic Lymphocytic Leukemia (CLL). We concentrate on three areas:
    1. signals from the microenvironment affecting CLL survival and chemo-resistance;
    2. new treatments that circumvent microenvironmental and p53-related chemo-resistance;
    3. murine models for CLL that incorporate aspects 1 and 2.
      We have recently founded LYMMCARE, the Lymphoma and Myeloma Center Amsterdam, a close collaboration between the AMC departments of Clinical Hematology, Experimental Immunology and Pathology. LYMMCARE provides a strong interaction between translational and clinical research, aimed at improving the treatment of patients with CLL, non-Hodgkin Lymphoma and multiple myeloma.
  2. Sickle Cell Disease
    Within the AMC Sickle cell Centre, a national expert centre treating about half of the Dutch sickle cell patients, we perform studies into the mechanisms of the probably inflammation-induced extensive vasculopathy, characteristic for this patient group.
  3. Immuno-hematology
    In close collaboration with the department of immunopathology at Sanquin we investigate the immunological mechanisms in autoimmune hemolytic anemia, and its consequences for immune activation. Moreover we develop new strategies for its treatment and prevention.
  4. Stem cell transplantation
    After a stem cell transplantation patients do have a strongly impaired immunity, resulting in long-term increased susceptibility for infections. Our group studies recovery of both innate and acquired immunity after autologous and allogeneic stem cell transplantation, and explores new venues for enhancing immune reconstitution

Clinical Research
Our department also participates in numerous national (HOVON) and international studies on new treatment modalities for a wide variety of haematological malignancies. AMC haematologists are the initiators and principal investigators of several of these studies.