Publications

Key publications of Oncogenomics

  • Valentijn LJ, Koster J, Haneveld F, Aissa RA, van Sluis P, Broekmans MEC, Molenaar JJ, van Nes J, Versteeg R, Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. P NATL ACAD SCI USA 2012;109 (47):19190-19195 [PubMed]
  • Molenaar JJ, Ebus ME, Geerts D, Koster J, Lamers F, Valentijn LJ, Westerhout EM, Versteeg R, Caron HN, Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells. P NATL ACAD SCI USA 2009;106 (31):12968-12973 [PubMed]
  • Molenaar JJ, Domingo-Fernández R, Ebus ME, Lindner S, Koster J, Drabek K, Mestdagh P, van Sluis P, Valentijn LJ, van Nes J, Broekmans M, Haneveld F, Volckmann R, Bray I, Heukamp L, Sprüssel A, Thor T, Kieckbusch K, Klein-Hitpass L, Fischer M, Vandesompele J, Schramm A, van Noesel MM, Varesio L, Speleman F, Eggert A, Stallings RL, Caron HN, Versteeg R, Schulte JH, LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. NAT GENET 2012;44 (11):1199-1206 [PubMed]
  • Molenaar JJ, Koster J, Zwijnenburg DA, van Sluis P, Valentijn LJ, van der Ploeg I, Hamdi M, van Nes J, Westerman BA, van Arkel J, Ebus ME, Haneveld F, Lakeman A, Schild L, Molenaar P, Stroeken P, van Noesel MM, Ora I, Santo EE, Caron HN, Westerhout EM, Versteeg R, Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. NATURE 2012;483 (7391):589-U107 [PubMed]
  • Gierman HJ, Indemans MHG, Koster J, Goetze S, Seppen J, Geerts D, van Driel R, Versteeg R, Domain-wide regulation of gene expression in the human genome. GENOME RES 2007;17 (9):1286-1295 [PubMed]
  • Rausch T, Jones DTW, Zapatka M, Stütz AM, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Blake J, Benes V, Kulozik AE, Witt O, Martin D, Zhang C, Porat R, Merino DM, Wasserman J, Jabado N, Fontebasso A, Bullinger L, Rücker FG, Döhner K, Döhner H, Koster J, Molenaar JJ, Versteeg R, Kool M, Tabori U, Malkin D, Korshunov A, Taylor MD, Lichter P, Pfister SM, Korbel JO, Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations. CELL 2012;148 (1-2):59-71 [PubMed]
  • Hölzel M, Huang S, Koster J, Ora I, Lakeman A, Caron H, Nijkamp W, Xie J, Callens T, Asgharzadeh S, Seeger RC, Messiaen L, Versteeg R, Bernards R, NF1 Is a Tumor Suppressor in Neuroblastoma that Determines Retinoic Acid Response and Disease Outcome. CELL 2010;142 (2):218-229 [PubMed]
  • Santo EE, Stroeken P, Sluis PV, Koster J, Versteeg R, Westerhout EM, FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma. CANCER RES 2013;73 (7):2189-2198 [PubMed]
  • Schaaf G, Hamdi M, Zwijnenburg D, Lakeman A, Geerts D, Versteeg R, Kool M, Silencing of SPRY1 Triggers Complete Regression of Rhabdomyosarcoma Tumors Carrying a Mutated RAS Gene. CANCER RES 2010;70 (2):762-771 [PubMed]