Principle Investigator: Wim van den Brink, M.D., Ph.D.

The Amsterdam Institute for Addiction Research is part of the Psychiatric division of the Academic Medical Center from the University of Amsterdam (AMC-UvA).

Our mission is to conduct patient-centered addiction research resulting in better- evidence based treatment of patients with addictive disorders. We intend to achieve this goal through the determination of factors that play a role in effective and efficient treatments and through the exploration of mechanisms underlying successful treatments.

Our vision is that the treatment of people with addiction problems should be based on scientific evidence and delivered by knowledgeable and dedicated professionals with a commitment to continuous improvement.

Our fundamental values are a rigorous scientific orientation, high ethical standards, multidisciplinary collaboration, and a strong dedication to the improvement of the lives of patients with addictive disorders.

Main objective
The main objective of the institute is to publish scientific research in prestigious national and international peer-reviewed journals. In addition, the staff contributes to scientific discussions via conferences and debates. The institute also provides support and advice to treatment centers in their attempts to evaluate and improve the treatment of people with addictive disorders.

Research overview
Our research program covers three major themes:

  1. Psychobiological research
    Research testing causes of initiation and prolongation of addictive behaviours, with topics like the psychobiology of craving, neurocognitive deficits associated with pathological gambling and addiction, neurotoxicity of ecstasy and other psychoactive substances, and neurobiological factors relevant for successful treatment process and treatment effectiveness.
  2. Treatment evaluation research
    Research testing the effectiveness of addiction treatment interventions and it’s underlying processes, with topics like treatment efficacy studies, treatment process evaluations, interventions for double diagnosis patients, and research testing patient-treatment matching procedures.
  3. Health services research
    Research testing healthcare interventions and healthcare systems, with topics like the dissemination and implementation of evidence-based interventions, studies on the quality of health care, cost-effectiveness evaluations, clinical decision making, program evaluation, and population surveys.

Research topics
  • Long-term course  of heroin assisted treatment - Peter Blanken
  • Dopamine and opiate craving in the human brain - Fleur Zijlstra
  • Feasibility and effectiveness of treatment allocation - Maarten Merkx
  • Influence of substance abuse on course of bipolar illness - Jan van Zaanen
  • Effect of cannabis use on course of schizophrenia - Daniel van Dijk
  • PTSD with secondary psychosis; a new entity? - Mario Braakman
  • Effect of methylphenidate in treatment of ADHD in addicted patients - Geurt van de Glind
  • Cross-cultural validity of psychosis diagnosis - Tehkle Zandi
  • Quality of forensic reporting in the Netherlands - Tryntsje van der Veer
  • Neurobehavioral pathways in addiction: an fMRI study - Ruth van Holst
  • Impulsivity: a treatable risk factor in addiction (exp clinical) - Lianne Schmaal
  • Impulsivity: a treatable risk factor in addiction (clinical) - Leen Joos
  • Impulsivity: a treatable risk factor in addiction (preclinical) - Nienke Boersma
  • Development of alcohol use disordesr: gene-environment interactions (Neuro Imaging) - Zsuszika Sjoerds
  • Development of alcohol use disordesr: gene-environment interactions (Epidemiology)) - Lynn Boschloo
  • Prevalence, treatment needs and new medications for cocaine dependence (Clinical) - Alberto Oteo
  • Transition from risky cannabis use to cannabis dependence (Epidemiology) - Peggy van de Poll
  • Transition from risky cannabis use to cannabis dependence (Sociology)) - Nienke Liebregts
  • Neurobiological and environmental predictors of persistence and desistence of disruptive behaviors in adolescents - Moran Cohn
  • Optimising addiction treatment by low intensity after care - Maarten Merkx
  • The role of dopamine in addiction and the relation between addiction and ADHD - Cleo Crunelle
  • Neurobiological and environmental predictors of transition in cannabis use, abuse and dependence - Janna Cousijn
  • ADHD and SUD - Katelijne van Oortmerssen
  • Obesity - Elsmarieke van de Giessen
  • Neuro-adaptation in adolescents treated with methyl phynyldate - Marco Bottelier
  • Indicators of drug use in the Netherlands - Tibor Brunt
  • Naltrexon treatment of Cannabis dependent pt - Eugene Schouten
  • ADHD-SUD - Linda Kronenberg