Researchers

  • Male

Dr. H.G. Ruhé

Position: Postdoc
Main activities: Patient care, Research
Specialisation: Psychiatry, Mood disorders, Pharmacology, Treatment resistance, Neuroimaging
foto
Focus of research:

My focusof research is the treatment of Major Depressive Disorder, and especially when patients do not respond to first and second line treatment (treatment resistant depression).

In order to better understand and quantify the brain mechanisms underlying treatment resistant depression, I use neuroimaging approaches like SPECT and fMRI.

Besides I am interested in using neuroimaging as a tool for inprovement of diagnosis in psychiatry, again focussed on mood disorders like Major Depressive Disorder and Bipolar Disorder

AMC themes: Neurological & Psychiatric Disorders
Departments: Psychiatry: Adult Psychiatry
Bergfeld IO, Mantione M, Hoogendoorn MLC, Ruhé HG, Horst F, Notten P, van Laarhoven J, van den Munckhof P, Beute G, Schuurman PR, Denys D, Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression. PSYCHOL MED 2017;47 (9):1647-1658 [PubMed]
Booiman T, Wit FW, Maurer I, de Francesco D, Sabin CA, Harskamp AM, Prins M, Garagnani P, Pirazzini C, Franceschi C, Fuchs D, Gisslén M, Winston A, Reiss P, Kootstra NA [Contributors: Reiss P, Wit FWNM, Schouten J , Kooij KW, van Zoest RA, Elsenga BC, Janssen FR, Heidenrijk M, Zikkenheiner W, van der Valk M, Kootstra NA, Booiman T, Harskamp-Holwerda AM, Boeser-Nunnink B, Maurer I, Mangas Ruiz MM, Girigorie AF, Villaudy J, Frankin E, Pasternak A, Berkhout B, van der Kuyl T, Portegies P, Schmand BA, Geurtsen GJ , ter Stege JA, Klein Twennaar M, Majoie CBLM, Caan MWA, Su T, Weijer K, Bisschop PHLT, Kalsbeek A, Wezel M, Visser I, Ruhé HG, Franceschi C, Garagnani P, Pirazzini C, Capri M, Dall'Olio F, Chiricolo M, Salvioli S, Hoeijmakers J, Pothof J, Prins M, Martens M, Moll S, Berkel J, Totté M, Kovalev S, Gisslén M, Fuchs D, Zetterberg H, Winston A, Underwood J, McDonald L, Stott M, Legg K, Lovell A, Erlwein O, Doyle N, Kingsley C, Sharp DJ, Leech R, Cole JH, Zaheri S, Hillebregt MMJ, Ruijs YMC, Benschop DP, Burger D, de Graaff-Teulen M, Guaraldi G, Bürkle A, Sindlinger T, Moreno-Villanueva M, Keller A, Sabin C, de Francesco D, Libert C, Dewaele S]] , High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid. OPEN FORUM INFECT DIS 2017;4 (3):ofx108 [PubMed]
Figueroa CA, Mocking RJT, van Wingen G, Martens S, Ruhé HG , Schene AH, Aberrant default-mode network-hippocampus connectivity after sad memory-recall in remitted-depression. SOC COGN AFFECT NEUR 2017;ahead of print [PubMed]
Hibar DP, Westlye LT, Doan NT, Jahanshad N, Cheung JW, Ching CRK, Versace A, Bilderbeck AC, Uhlmann A, Mwangi B, Krämer B, Overs B, Hartberg CB, Abé C, Dima D, Grotegerd D, Sprooten E, Bøen E, Jimenez E, Howells FM, Delvecchio G, Temmingh H, Starke J, Almeida JRC, Goikolea JM, Houenou J, Beard LM, Rauer L, Abramovic L, Bonnin M, Ponteduro MF, Keil M, Rive MM , Yao N, Yalin N, Najt P, Rosa PG, Redlich R, Trost S, Hagenaars S, Fears SC, Alonso-Lana S, van Erp TGM, Nickson T, Chaim-Avancini TM, Meier TB, Elvsåshagen T, Haukvik UK, Lee WH, Schene AH, Lloyd AJ, Young AH, Nugent A, Dale AM, Pfennig A, McIntosh AM, Lafer B, Baune BT, Ekman CJ, Zarate CA, Bearden CE, Henry C, Simhandl C, McDonald C, Bourne C, Stein DJ, Wolf DH, Cannon DM, Glahn DC, Veltman DJ, Pomarol-Clotet E, Vieta E, Canales-Rodriguez EJ, Nery FG, Duran FLS, Busatto GF, Roberts G, Pearlson GD, Goodwin GM, Kugel H, Whalley HC, Ruhe HG, Soares JC, Fullerton JM, Rybakowski JK, Savitz J, Chaim KT, Fatjó-Vilas M, Soeiro-de-Souza MG, Boks MP, Zanetti MV, Otaduy MCG, Schaufelberger MS, Alda M, Ingvar M, Phillips ML, Kempton MJ, Bauer M, Landén M, Lawrence NS, van Haren NEM, Horn NR, Freimer NB, Gruber O, Schofield PR, Mitchell PB, Kahn RS, Lenroot R, Machado-Vieira R, Ophoff RA, Sarró S, Frangou S, Satterthwaite TD, Hajek T, Dannlowski U, Malt UF, Arolt V, Gattaz WF, Drevets WC, Caseras X, Agartz I, Thompson PM, Andreassen OA, Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. MOL PSYCHIATR 2017;ahead of print [PubMed]
Mocking RJT , Nap TS, Westerink AM, Assies J , Vaz FM, Koeter MWJ, Ruhé HG, Schene AH, Biological profiling of prospective antidepressant response in major depressive disorder: Associations with (neuro)inflammation, fatty acid metabolism, and amygdala-reactivity. PSYCHONEUROENDOCRINO 2017;79:84-92 [PubMed]
Rive MM. Bipolar or unipolar? A brain teasing question. S.l.: s.n.; 2017. 345p. ISBN 978-90-826049-5-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Schene AH, Veltman DJ; copromotor(s): Ruhé HG)
Servaas MN, Riese H, Renken RJ, Wichers M, Bastiaansen JA, Figueroa CA, Geugies H, Mocking RJT, Geerligs L, Marsman JBC, Aleman A, Schene AH, Schoevers RA, Ruhé HG, Associations between Daily Affective Instability and Connectomics in Functional Subnetworks in Remitted Patients with Recurrent Major Depressive Disorder. NEUROPSYCHOPHARMACOL 2017;-:- [PubMed]
van Rooijen G, Isvoranu AM, Kruijt OH, van Borkulo CD, Meijer CJ, Wigman JTW, Ruhé HG , de Haan L [Contributors: Bruggeman R, Cahn W, de Haan L, Kahn RS, Meijer C, Myin-Germeys I, van Os J, Bartels-Velthuis AA]] , A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders. SCHIZOPHR RES 2017;ahead of print [PubMed]
van Rooijen G, Isvoranu AM, Meijer CJ, van Borkulo CD, Ruhé HG , de Haan L, A symptom network structure of the psychosis spectrum. SCHIZOPHR RES 2017;ahead of print [PubMed]
van Rooijen G, Vermeulen JM, Ruhé HG, de Haan L, Treating depressive episodes or symptoms in patients with schizophrenia. CNS SPECTRUMS 2017;ahead of print [PubMed]
Bergfeld IO, Mantione M, Hoogendoorn MLC, Ruhé HG , Notten P, van Laarhoven J, Visser I , Figee M, de Kwaasteniet BP, Horst F, Schene AH, van den Munckhof P, Beute G, Schuurman R, Denys D, Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Treatment-Resistant Depression: A Randomized Clinical Trial. JAMA PSYCHIAT 2016;73 (5):456-464 [PubMed]
Cobos Jiménez V, Wit FWNM, Joerink M, Maurer I, Harskamp AM, Schouten J, Prins M, van Leeuwen EMM, Booiman T, Deeks SG, Reiss P, Kootstra NA [Contributors: Reiss P, Wit FWNM, van der Valk M, Schouten J , Kooij KW, van Zoest RA, Elsenga BC, Prins M, Martens M, Moll S, Berkel J, Totté M, Visser GR, Kovalev S, Zaheri S, Hillebregt MMJ, Ruijs YMC, Benschop DP, Reis P, Janssen FR, Heidenrijk M, Zikkenheiner W, Boumans L, Kootstra NA, Harskamp-Holwerda AM, Maurer I, Mangas Ruiz MM, Girigorie AF, Boeser-Nunnink B, Geerlings SE, Godfried MH, Goorhuis A, Hovius JWR, Nellen FJB, van der Meer JTM, van der Poll T, Prins JM, Wiersinga WJ, van Eden J, van Hes AMH, Mutschelknauss M, Nobel HE, Pijnappel FJJ, Westerman AM, de Jong J, Postema PG, Bisschop PHLT, Serlie MJM, Lips P, Dekker E, de Rooij SEJA, Willemsen JMR, Vogt L, Portegies P, Schmand BA, Geurtsen GJ , ter Stege JA, Klein Twennaar M, van Eck-Smit BLF, de Jong M, Richel DJ, Verbraak FD, Demirkaya N , Visser I, Ruhé HG, Nieuwkerk PT, van Steenwijk RP, Dijkers E, Majoie CBLM, Caan MWA, Su T, van Lunsen HW, Nievaard MAF, van den Born BJH, Stroes ESG, Mulder WMC]] , T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment. J INFECT DIS 2016;214 (2):216-225 [PubMed]
Demirkaya N, Wit FWNM, van den Berg TJTP, Kooij KW, Prins M, Schlingemann RO, Abramoff MD, Reiss P, Verbraak FD [Contributors: Reiss P, Wit FWNM, van der Valk M, Schouten J, Kooij KW, van Zoest RA, Elsenga BC, Prins M, Martens M, Moll S, Berkel J, Totté M, Visser GR, Kovalev S, Zaheri S, Hillebregt MMJ, Ruijs YMC, Benschop DP, Kootstra NA, Harskamp-Holwerda A, Maurer I, Ruiz MMM, Girigorie AF, van Leeuwen E, Janssen FR, Heidenrijk M, Zikkenheiner W, Boumans L, Wezel M, Jansen-Kok CSM, Geerlings SE, Godfried MH, Goorhuis A, Hovius JWR, van der Meer JTM, Nellen FJB, van der Poll T, Prins JM, Wiersinga WJ, van Eden J, van Hes AMH, Mutschelknauss M, Nobel HE, Pijnappel FJJ, Westerman AM, de Jong J, Postema PG, Bisschop PHLT, Serlie MJM, Lips P, Dekker E, de Rooij SEJA, Willemsen JMR, Vogt L, Portegies P, Schmand BA, Geurtsen GJ , Stege JAt, Twennaar MK, van Eck-Smit BLF, de Jong M, Richel DJ, Verbraak FD, Demirkaya N , Visser I, Ruhé HG, Nieuwkerk PT, van Steenwijk RP, Dijkers E, Majoie CBLM, Caan MWA, Su T, van Lunsen HW, Nievaard MAF, van den Born BJH, Stroes ESG, Mulder WMC]] , HIV-Associated Neuroretinal Disorder in Patients With Well-Suppressed HIV-Infection: A Comparative Cohort Study. INVEST OPHTH VIS SCI 2016;57 (3):1388-1397 [PubMed]
Furukawa TA, Salanti G, Atkinson LZ, Leucht S, Ruhe HG, Turner EH, Chaimani A, Ogawa Y, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Suganuma A, Watanabe N, Stockton S, Geddes JR, Cipriani A, Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis. BMJ OPEN 2016;6 (7):e010919 [PubMed]
Huijbers MJ, Spinhoven P, Spijker J, Ruhé HG , van Schaik DJF, van Oppen P, Nolen WA, Ormel J, Kuyken W, van der Wilt GJ, Blom MBJ, Schene AH, Rogier A, Donders T, Speckens AEM, Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial. BRIT J PSYCHIAT 2016;208 (4):366-373 [PubMed]
Korucuoglu O, Gladwin TE, Baas F, Mocking RJT, Ruhé HG , Groot PFC, Wiers RW, Neural response to alcohol taste cues in youth: effects of the OPRM1 gene. ADDICT BIOL 2016;ahead of print [PubMed]
Mocking RJT, Figueroa CA, Rive MM, Geugies H, Servaas MN, Assies J, Koeter MWJ, Vaz FM, Wichers M, van Straalen JP, de Raedt R, Bockting CLH, Harmer CJ, Schene AH, Ruhé HG, Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study. BMJ OPEN 2016;6 (3):e009510 [PubMed]
Mocking RJT , Harmsen I, Assies J , Koeter MWJ, Ruhé HG, Schene AH, Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. TRANSL PSYCHIAT 2016;6:e756 [PubMed]
Peeters FPML, Ruhe HG, Wichers M, Abidi L, Kaub K, van der Lande HJ, Spijker J, Huibers MJH, Schene AH, The Dutch Measure for quantification of Treatment Resistance in Depression (DM-TRD): an extension of the Maudsley Staging Method. J AFFECT DISORDERS 2016;205:365-371 [PubMed]
Rive MM , Koeter MWJ, Veltman DJ, Schene AH, Ruhé HG, Visuospatial planning in unmedicated major depressive disorder and bipolar disorder: distinct and common neural correlates. PSYCHOL MED 2016;46 (11):2313-2328 [PubMed]
Rive MM, Redlich R, Schmaal L, Marquand AF, Dannlowski U, Grotegerd D, Veltman DJ, Schene AH, Ruhé HG, Distinguishing medication-free subjects with unipolar disorder from subjects with bipolar disorder: state matters. BIPOLAR DISORD 2016;18 (7):612-623 [PubMed]
Schouten J, Su T, Wit FW, Kootstra NA, Caan MWA, Geurtsen GJ, Schmand BA, Stolte IG, Prins M, Majoie CB, Portegies P, Reiss P [Contributors: Reiss P, Wit FWNM, van der Valk M, Schouten J , Kooij KW, van Zoest RA, Elsenga BC, Prins M, Stolte IG, Martens M, Moll S, Berkel J, Möller L, Visser GR, Welling C, Zaheri S, Hillebregt MMJ, Gras LAJ, Ruijs YMC, Benschop DP, Kootstra NA, Harskamp-Holwerda AM, Maurer I, Ruiz M, Girigorie AF, van Leeuwen E, Janssen FR, Heidenrijk M, Schrijver JHN, Zikkenheiner W, Wezel M, Jansen-Kok CSM, Geerlings SE, Godfried MH, Goorhuis A, van der Meer JTM, Nellen FJB, van der Poll T, Prins JM, Wiersinga WJ, van Eden J, Pijnappel FJJ, Westerman AM, de Jong J, Postema PG, Bisschop PHLT, Serlie MJM, Lips P, Dekker E, de Rooij SEJA, Willemsen JMR, Vogt L, ter Stege JA, Twennaar MK, van Eck-Smit BLF, de Jong M, Richel DJ, Verbraak FD, Demirkaya N , Visser I, Ruhé HG, Schmand BA, Geurtsen GJ , Nieuwkerk PT, van Steenwijk RP, Dijkers E, Majoie CBLM, Caan MWA, Su T, van Lunsen HW, Nievaard MAF, van den Born BJH, Stroes ESG, Mulder WMC]] , Determinants of reduced cognitive performance in HIV-1-infected middle-aged men on combination antiretroviral therapy. AIDS 2016;30 (7):1027-1038 [PubMed]
ten Kulve JS, Veltman DJ, van Bloemendaal L, Groot PFC, Ruhé HG , Barkhof F, Diamant M, Ijzerman RG, Endogenous GLP1 and GLP1 analogue alter CNS responses to palatable food consumption. J ENDOCRINOL 2016;229 (1):1-12 [PubMed]
Assies J, Mocking RJT, Lok A , Koeter MWJ, Bockting CLH, Visser I , Pouwer F, Ruhé HG , Schene AH, Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: Implications for co-morbidity with cardiovascular disease. PSYCHIAT RES 2015;229 (3):992-998 [PubMed]
Bottelier MA, Schouw MLJ, de Ruiter MB, Ruhe HG, Lindauer RJL, Reneman L, Effects of methylphenidate during emotional processing in amphetamine users: preliminary findings. BRAIN IMAGING BEHAV 2015;9 (4):878-886 [PubMed]
de Kwaasteniet BP. Neurobiological mechanisms of treatment resistant depression: Functional, structural and molecular imaging studies. S.l.: s.n.; 2015. 185p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys D; copromotor(s): Ruhé E, van Wingen G)
de Kwaasteniet BP, Pinto C, Ruhé HG , van Wingen GA, Booij J, Denys D, Striatal Dopamine D-2/3 Receptor Availability in Treatment Resistant Depression (vol 9, e113612, 2014). PLOS ONE 2015;10 (8):e0135764 [PubMed]
de Kwaasteniet BP, Rive MM, Ruhé HG , Schene AH, Veltman DJ, Fellinger L, van Wingen GA, Denys D, Decreased resting-state connectivity between neurocognitive networks in treatment resistant depression. FRONT PSYCHIATRY 2015;6:28 [PubMed]
Figueroa CA, Ruhé HG , Koeter MW, Spinhoven P, van der Does W, Bockting CL, Schene AH, Cognitive reactivity versus dysfunctional cognitions and the prediction of relapse in recurrent major depressive disorder. J CLIN PSYCHIAT 2015;76 (10):e1306-e1312 [PubMed]
Mocking RJT , Pellikaan CM, Lok A , Assies J , Ruhé HG, Koeter MW, Visser I, Bockting CL, Olff M, Schene AH, DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence?. PSYCHONEUROENDOCRINO 2015;59:91-101 [PubMed]
Mocking RJT, Verburg HF, Westerink AM, Assies J, Vaz FM, Koeter MWJ, Ruhé HG , Schene AH, Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response. PSYCHONEUROENDOCRINO 2015;59:1-13 [PubMed]
Rive MM, Mocking RJT, Koeter MWJ, van Wingen G, de Wit SJ, van den Heuvel OA, Veltman DJ, Ruhé HG , Schene AH, State-Dependent Differences in Emotion Regulation Between Unmedicated Bipolar Disorder and Major Depressive Disorder. JAMA PSYCHIAT 2015;72 (7):687-696 [PubMed]
Ruhé HG , Khoenkhoen SJ, Ottenhof KW, Koeter MW, Mocking RJT, Schene AH, Longitudinal effects of the SSRI paroxetine on salivary cortisol in Major Depressive Disorder. PSYCHONEUROENDOCRINO 2015;52:261-271 [PubMed]
Schmaal L, Marquand AF, Rhebergen D, van Tol MJ, Ruhé HG , van der Wee NJA, Veltman DJ, Penninx BWJH, Predicting the Naturalistic Course of Major Depressive Disorder Using Clinical and Multimodal Neuroimaging Information: A Multivariate Pattern Recognition Study. BIOL PSYCHIAT 2015;78 (4):278-286 [PubMed]
van Bloemendaal L, Veltman DJ, ten Kulve JS, Groot PFC, Ruhé HG, Barkhof F, Sloan JH, Diamant M, Ijzerman RG, Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagon-like peptide-1 receptor activation in humans. DIABETES OBES METAB 2015;17 (9):878-886 [PubMed]
Assies J , Mocking RJT , Lok A , Ruhé HG, Pouwer F, Schene AH, Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity. ACTA PSYCHIAT SCAND 2014;130 (3):163-180 [PubMed]
Bottelier MA, Schouw MLJ, Klomp A, Tamminga HGH, Schrantee AGM, Bouziane C, de Ruiter MB, Boer F, Ruhé HG , Denys D, Rijsman R, Lindauer RJL, Reitsma HB, Geurts HM, Reneman L, The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design. BMC PSYCHIATRY 2014;14 (1):48 [PubMed]
de Kwaasteniet BP, Pinto C, Ruhé HG , Ruhé EHG, van Wingen GA, Booij J, Denys D, Striatal dopamine D2/3 receptor availability in treatment resistant depression. PLOS ONE 2014;9 (11):e113612 [PubMed]
Haarman BCM, Riemersma van der Lek RF, Ruhé HG , de Groot JC, Nolen WA, Doorduin J. Bipolar disorders in: Dierckx RAJO, Otte A, de Vries EFJ, van Waarde A, den Boer JA, editors. PET and SPECT in psychiatry. Berlin; Heidelberg: Springer; 2014., p. 223-251
Ruhé HG , Koster M, Booij J, van Herk M, Veltman DJ, Schene AH, Occupancy of serotonin transporters in the amygdala by paroxetine in association with attenuation of left amygdala activation by negative faces in major depressive disorder. PSYCHIAT RES 2014;221 (2):155-161 [PubMed]
Ruhé HG , Visser AKD, Frokjaer VG, Haarman BCM, Klein HC, Booij J. Molecular imaging of depressive disorders in: Dierckx RAJO, Otte A, de Vries EFJ, van Waarde A, den Boer JA, editors. PET and SPECT in psychiatry. Berlin; Heidelberg: Springer; 2014., p. 93-172
Schouten J, Wit FW, Stolte IG, Kootstra NA, van der Valk M, Geerlings SE, Prins M, Reiss P [Contributors: Wit FWNM, van der Valk M, Schouten J, Kooij KW, van Zoest RA, Elsenga BC, Prins M, Stolte IG, Martens M, Moll S, Berkel J, Möller L, Visser GR, Welling C, Zaheri S, Hillebregt MMJ, Gras LAJ, Ruijs YMC, Benschop DP, Reiss P, Kootstra NA, Harskamp-Holwerda AM, Maurer I, Ruiz MMM, Girigorie AF, van Leeuwen E, Janssen FR, Heidenrijk M, Schrijver JHN, Zikkenheiner W, Wezel M, Jansen-Kok CSM, Geerlings SE, Godfried MH, Goorhuis A, van der Meer JTM, Nellen FJB, van der Poll T, Prins JM, Wiersinga WJ, van Eden J, Henderiks A, van Hes AMH, Mutschelknauss M, Nobel HE, Pijnappel FJJ, Westerman AM, de Jong J, Postema PG, Bisschop PHLT, Serlie MJM, Lips P, Dekker E, de Rooij SEJA, Willemsen JMR, Vogt L, Portegies P, Schmand BA, Geurtsen GJ , Stege JAt, Twennaar MK, van Eck-Smit BLF, de Jong M, Richel DJ, Verbraak FD, Demirkaya N , Visser I, Ruhé HG, Nieuwkerk PT, van Steenwijk RP, Dijkers E, Majoie CBLM, Caan MWA, Su T, van Lunsen HW, Nievaard MAF, van den Born BJH, Stroes ESG, Mulder WMC]] , Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study. CLIN INFECT DIS 2014;59 (12):1787-1797 [PubMed]
de Kwaasteniet B, Ruhe E , Caan M, Rive M , Olabarriaga S, Groefsema M, Heesink L, van Wingen G, Denys D, Relation between structural and functional connectivity in major depressive disorder. BIOL PSYCHIAT 2013;74 (1):40-47 [PubMed]
Mocking RJT, Lok A , Assies J, Koeter MWJ, Visser I , Ruhé HG , Bockting CLH, Schene AH, Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference. PLOS ONE 2013;8 (12):e82980 [PubMed]
Mocking RJT, Ruhé HG , Assies J, Lok A , Koeter MWJ, Visser I , Bockting CLH, Schene AH, Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. PSYCHONEUROENDOCRINO 2013;38 (9):1607-1617 [PubMed]
Rive MM, van Rooijen G, Veltman DJ, Phillips ML, Schene AH, Ruhé HG, Neural correlates of dysfunctional emotion regulation in major depressive disorder. A systematic review of neuroimaging studies. NEUROSCI BIOBEHAV R 2013;37 (10 Part 2):2529-2553 [PubMed]
van Rijsbergen GD, Bockting CLH, Burger H, Spinhoven P, Koeter MWJ, Ruhé HG , Hollon SD, Schene AH, Mood reactivity rather than cognitive reactivity is predictive of depressive relapse: a randomized study with 5.5-year follow-up. J CONSULT CLIN PSYCH 2013;81 (3):508-517 [PubMed]
Bao AM, Ruhé HG, Gao SF, Swaab DF, Neurotransmitters and neuropeptides in depression. HANDB CLIN NEUROL 2012;106:107-136 [PubMed]
Huijbers MJ, Spijker J, Donders ART, van Schaik DJ, van Oppen P, Ruhé HG , Blom MBJ, Nolen WA, Ormel J, van der Wilt GJ, Kuyken W, Spinhoven P, Speckens AEM, Preventing relapse in recurrent depression using mindfulness-based cognitive therapy, antidepressant medication or the combination: trial design and protocol of the MOMENT study. BMC PSYCHIATRY 2012;12:125 [PubMed]
Lok A , Mocking RJT, Ruhé HG , Visser I , Koeter MWJ, Assies J, Bockting CLH, Olff M, Schene AH, Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression. PSYCHONEUROENDOCRINO 2012;37 (7):892-902 [PubMed]
Mocking RJT, Assies J, Koeter MWJ, Ruhé HG , Lok A , Schene AH, Bimodal Distribution of Fatty Acids in Recurrent Major Depressive Disorder. BIOL PSYCHIAT 2012;71 (1):E3-E5 [PubMed]
Mocking RJT, Assies J, Lok A , Ruhé HG , Koeter MWJ, Visser I , Bockting CLH, Schene AH, Statistical Methodological Issues in Handling of Fatty Acid Data: Percentage or Concentration, Imputation and Indices. LIPIDS 2012;47 (5):541-547 [PubMed]
Peeters FPML, Ruhé HG, Beekman ATF, Spijker J, Schoevers R, Zitman F, Schene A, Stagering en profilering van unipolaire depressie. TIJDSCHR PSYCHIATR 2012;54 (11):957-963
Ruhé HG , Booij J, Veltman DJ, Michel MC, Schene AH, Successful Pharmacologic Treatment of Major Depressive Disorder Attenuates Amygdala Activation to Negative Facial Expressions: A Functional Magnetic Resonance Imaging Study. J CLIN PSYCHIAT 2012;73 (4):451-459 [PubMed]
Ruhé HG , van Rooijen G, Spijker J, Peeters FPML, Schene AH, Staging methods for treatment resistant depression. A systematic review. J AFFECT DISORDERS 2012;137 (1-3):35-45 [PubMed]
Ruhé HG, Commentaar: Algoritmes voor de biologische behandelingen van depressie. TIJDSCHR PSYCHIATR 2011;53 (4):235-238
Ruhé HG, Booij J, Schene AH, Onvoldoende response op een standaarddosering van een SSRI bij unipoliare depressie: dosisverhoging?. PSYFAR 2011;6 (1):19-23
Ruhé HG, Booij J, Schene AH, Wat te doen als de eerste pil niet werkt: dosisverhoging of toch liever switchen?. PSYFAR 2011;6 (1):24-27
Schene AH, Ruhé HG, In het kort: Resultaten van onderzoek naar antidepressiva zijn generaliseerbaar naar de dagelijkse praktijk. NED TIJDSCHR GENEESKD 2011;155:A3217
Visser I , Wekking EM, de Boer AGEM, de Joode EA, van Hout MSE, van Dorsselaer S, Ruhé HG , Huijser J, Van der Laan G , van Dijk FJH, Schene AH, Prevalence of psychiatric disorders in patients with chronic solvent induced encephalopathy (CSE). NEUROTOXICOLOGY 2011;32 (6):916-922 [PubMed]
Ruhé HG, Birkenhäger TK. Vervolgstappen bij depressie in: Verkes RJ, Ruhe HG, editors. Keuzecriteria voor antidepressiva. Alphen a/d Rijn: Van Zuiden; 2010., p. 117-133
Ruhé HG, Booij J, van Weert HC, Reitsma JB, Franssen EJ, Michel MC, Schene A, Dosisverhoging van SSRI'S bij depressie; niet aan te bevelen in richtlijnen. TIJDSCHR PSYCHIATR 2010;52 (9):615-625 [PubMed]
Ruhé HG, Franx G, Peeters F, van Rijswijk E, Spijker J, Bruinvels DJ, Verkes RJ, Schene AH. Farmacotherapie voor depressie in de praktijk in: Verkes RJ, Ruhe HG, editors. Keuzecriteria voor antidepressiva. Alphen a/d Rijn: Van Zuiden; 2010., p. 143-165
Ruhe HG, Wijkstra J, Peeters FPML. Antidepressiva bij stemmingsstoornissen in: Verkes RJ, Ruhe HG, editors. Keuzecriteria voor antidepressiva. Alphen a/d Rijn: Van Zuiden; 2010., p. 27-45
Veltman DJ, Ruhé HG, Booij J, Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings. CURR PHARM DESIGN 2010;16 (18):1979-1989 [PubMed]
Verkes RJ, Ruhe HG, editors, Keuzecriteria voor antidepressiva. Alphen a/d Rijn: Van Zuiden; 2010. -p. ISBN 978-90-8523-213-1
Abdelmalik N, Ruhé HG, Barwari K, van den Dool EJ, Meijers JCM, Middeldorp S, Büller HR, Schene AH, Kamphuisen PW, Het effect van de selectieve serotonineheropnameremmer paroxetine op de bloedplaatjesfunctie wordt beïnvloed door een SLC6A4-serotoninetransporterpolymorfisme. NED TIJDSCHR HEMATOL 2009;6 (6):211-219
Baas KD , Wittkampf KA, van Weert HC, Lucassen P, Huyser J, van den Hoogen H, van de Lisdonk E, Bindels PE, Bockting CL, Ruhé HG , Schene AH, Screening for depression in high-risk groups: prospective cohort study in general practice. BRIT J PSYCHIAT 2009;194 (5):399-403 [PubMed]
Ruhé E, Booij J, van Weert H, Reitsma J, Fransen E, Michel M, Schene A, Dosisverhoging SSRI's bij depressie is niet zinvol. HUISARTS WET 2009;6 (52):289-296
Ruhé HG, Escitalopram en sertraline. Antidepressiva van eerste keus in richtlijn 'depressie'?. NED TIJDSCHR GENEESKD 2009;153:A564
Ruhé HG , Booij J, Reitsma JB, Schene AH, Serotonin transporter binding with [123I]beta-CIT SPECT in major depressive disorder versus controls: effect of season and gender. EUR J NUCL MED MOL I 2009;36 (5):841-849 [PubMed]
Ruhé HG , Booij J, Weert HCV, Reitsma JB, Fransen EJF, Michel MC, Schene AH, Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder: A Randomized Controlled Trial With Assessment of Serotonin Transporter Occupancy. NEUROPSYCHOPHARMACOL 2009;34 (4):999-1010 [PubMed]
Ruhé HG , Ooteman W, Booij J, Michel MC, Moeton M, Baas F, Schene AH, Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder. PHARMACOGENET GENOM 2009;19 (1):67-76 [PubMed]
Abdelmalik N, Ruhé HG, Barwari K, van den Dool EJ, Meijers JCM, Middeldorp S, Büller HR, Schene AH, Kamphuisen PW, Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism. J THROMB HAEMOST 2008;6 (12):2168-2174 [PubMed]
Ruhé HG. Dose-escalation in the picture. Pharmacological and imaging studies in depression. s.l.: s.n.; 2008. 300p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Schene AH; copromotor(s): Booij J)
Baas KD , Ruhé HG, Referaat:: Gedragsactivatie is effectief bij de behandeling van depressie. TIJDSCHR PSYCHIATR 2007;49 (2):6
Ruhé HG, Polymorfisme van het serotoninetransporteiwit niet gerelateerd aan respons, maar wel aan bijwerkingen bij citalopramgebruik. NED TIJDSCHR GENEESKD 2007;151 (47):2641
Ruhe HG, Mason NS, Schene AH, Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. MOL PSYCHIATR 2007;12 (4):331-359 [PubMed]
Michel MC, Ruhe HG, de Groot AA, Castro R, Oelke M, Tolerability of amine uptake inhibitors in urologic diseases. CURR DRUG SAF 2006;1 (1):73-85 [PubMed]
Ruhé HG, Suïciderisico door antidepressiva opnieuw onder de loep genomen. TIJDSCHR PSYCHIATR 2006;48 (6):494-495
Ruhé HG , Huyser J, Swinkels JA, Schene AH, Dose escalation for insufficient response to standard-dose selective serotonin reuptake inhibitors in major depressive disorder: systematic review. BRIT J PSYCHIAT 2006;189:309-316 [PubMed]
Ruhé HG , Huyser J, Swinkels JA, Schene AH, Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder: a systematic review. J CLIN PSYCHIAT 2006;67 (12):1836-1855 [PubMed]
Huyser J, Haages M, Eussen NJPM, Ruhé HG, Schene AH, editors, Serie publicaties Programma Stemmingsstoornissen. Amsterdam: AMC/De Meren; 2005. -p. ISBN 90-78129-01-8
Ruhé HG , Dekker JJ, Peen J, Holman R, de Jonghe F, Clinical use of the Hamilton Depression Rating Scale: is increased efficiency possible? A post hoc comparison of Hamilton Depression Rating Scale, Maier and Bech subscales, Clinical Global Impression, and Symptom Checklist-90 scores. COMPR PSYCHIAT 2005;46 (6):417-427 [PubMed]
Ruhé HG, Swinkels J, Schene AH, Dosisverhoging en omschakeling liggen meest voor de hand. PHARM WEEKBL 2005;44:1382-1387
Schene AH, Ruhé E, Huyser J. De validiteit van de diagnose 'depressie' in: Koerselman GF, Korzec A, Vergouwen ACM, editors. De gecompliceerde kliniek 2005: over de geldigheid van diagnoses. Amsterdam: Benecke N.I.; 2004.
Ruhé HG, Farmacotherapie bij unipolaire depressie. BIJBLIJVEN 2003;19 (9):12-25
Ruhé HG, Review: Low dose tricyclic antidepressants may be effective for adults with acute depressive disorder. EVID BASED MENT HEALTH 2003;6 (2):46 [PubMed]
Ruhé HG, Becker HE, Jessurun P, Marees CH, Heeringa M, Vermeulen HD, Agranulocytosis and granulocytopenia associated with quetiapine. ACTA PSYCHIAT SCAND 2001;104 (4):311-3; discussion 313-4 [PubMed]
Ruhé HG, Huyser J, Swinkels JA , Schene AH. Wat te doen als de eerste pil niet werkt? Een evidence-based richtlijn voor de biologische behandeling van depressie bij onvoldoende respons op een standaarddosering van een eerste SSRI. S.l.: s.n.; 2001. -p.
Key publications

Ruhé HG. Dose-escalation in the picture. Pharmacological and imaging studies in depression. s.l.: s.n.; 2008. 300p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Schene AH; copromotor(s): Booij J)
Ruhe HG, Mason NS, Schene AH, Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. MOL PSYCHIATR 2007;12 (4):331-359 [PubMed]
Ruhé HG , Booij J, Weert HCV, Reitsma JB, Fransen EJF, Michel MC, Schene AH, Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder: A Randomized Controlled Trial With Assessment of Serotonin Transporter Occupancy. NEUROPSYCHOPHARMACOL 2009;34 (4):999-1010 [PubMed]
Ruhé HG , Huyser J, Swinkels JA, Schene AH, Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder: a systematic review. J CLIN PSYCHIAT 2006;67 (12):1836-1855 [PubMed]
Ruhé HG , Huyser J, Swinkels JA, Schene AH, Dose escalation for insufficient response to standard-dose selective serotonin reuptake inhibitors in major depressive disorder: systematic review. BRIT J PSYCHIAT 2006;189:309-316 [PubMed]


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