Researchers

  • Female

Dr. M.W.J. Machielsen MD

Position: PhD student
Main activities: Research
Specialisation: Psychiatry
foto
Focus of research:

Effect of different antipsychotic medication on craving related brain activity in patients with schizophrenia and cannabis abuse or dependence: a randomized controlled study comparing clozapine and risperidone

AMC themes: Neurological & Psychiatric Disorders
Departments: Psychiatry: Adult Psychiatry
Machielsen MWJ, Veltman DJ, van den Brink W, de Haan L, Comparing the effect of clozapine and risperidone on cue reactivity in male patients with schizophrenia and a cannabis use disorder: A randomized fMRI study. SCHIZOPHR RES 2017;ahead of print [PubMed]
Koenders L. Structural brain alterations and cannabis in the healthy population and patients with schizophrenia. S.l.: s.n.; 2016. 220p. ISBN 9789082604900 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de Haan L, Veltman DJ; copromotor(s): Meijer CJ, Machielsen MWJ)
Koenders L, Cousijn J, Vingerhoets WAM, van den Brink W, Wiers RW, Meijer CJ, Machielsen MWJ, Veltman DJ, Goudriaan AE, de Haan L, Grey Matter Changes Associated with Heavy Cannabis Use: A Longitudinal sMRI Study. PLOS ONE 2016;11 (5):e0152482 [PubMed]
van Erp TGM, Hibar DP, Rasmussen JM, Glahn DC, Pearlson GD, Andreassen OA, Agartz I, Westlye LT, Haukvik UK, Dale AM, Melle I, Hartberg CB, Gruber O, Kraemer B, Zilles D, Donohoe G, Kelly S, McDonald C, Morris DW, Cannon DM, Corvin A, Machielsen MWJ, Koenders L, de Haan L, Veltman DJ, Satterthwaite TD, Wolf DH, Gur RC, Gur RE, Potkin SG, Mathalon DH, Mueller BA, Preda A, Macciardi F, Ehrlich S, Walton E, Hass J, Calhoun VD, Bockholt HJ, Sponheim SR, Shoemaker JM, van Haren NEM, Hulshoff Pol HE, Pol HEH, Ophoff RA, Kahn RS, Roiz-Santiañez R, Crespo-Facorro B, Wang L, Alpert KI, Jönsson EG, Dimitrova R, Bois C, Whalley HC, McIntosh AM, Lawrie SM, Hashimoto R, Thompson PM, Turner JA, Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. MOL PSYCHIATR 2016;21 (4):547-553 [PubMed]
Heering HD, Koevoets GJC, Koenders L, Machielsen MWJ, Meijer CJ, Kubota M, de Nijs J, Cahn W, Hulshoff Pol HE, de Haan L, Kahn RS, van Haren NEM, Structural MRI differences between patients with and without first rank symptoms: a delusion?. FRONT PSYCHIATRY 2015;6:107 [PubMed]
Houwert-Steins Bisschop CN, Zantvoord JB , Machielsen MWJ, Koeter M, van den Brink W, 'Dosisreductiestrategie in plaats van onderhouds-behandeling na eerste psychose: op lange termijn tweemaal zo vaak herstel' Houwert-Steins Bisschop e.a. TIJDSCHR PSYCHIATR 2015;57 (4):305-308 [PubMed]
Koenders L, Machielsen MWJ, van der Meer FJ, van Gasselt ACM, Meijer CJ, van den Brink W, Koeter MWJ, Caan MWA, Cousijn J, den Braber A, van 't Ent D, Rive MM, Schene AH, van de Giessen E, Huyser C , de Kwaasteniet BP, Veltman DJ, de Haan L, Brain volume in male patients with recent onset schizophrenia with and without cannabis use disorders. J PSYCHIATR NEUROSCI 2015;40 (3):197-206 [PubMed]
Luijten M, Machielsen MWJ, Veltman DJ, Hester R, de Haan L, Franken IHA, Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people with substance dependence and behavioural addictions. J PSYCHIATR NEUROSCI 2014;39 (3):149-169 [PubMed]
Machielsen MWJ. Schizophrenia and comorbid cannabis use disorders. Brain structure, function and the effect of antipsychotic medications. s.l.: s.n.; 2014. 245p. ISBN 9789088918131 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de Haan L, Veltman DJ; copromotor(s): van den Brink W)
Machielsen MWJ, Veltman DJ, van den Brink W, de Haan L, The effect of clozapine and risperidone on attentional bias in patients with schizophrenia and a cannabis use disorder: An fMRI study. J PSYCHOPHARMACOL 2014;28 (7):633-642 [PubMed]
Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, Appel K, Armstrong NJ, Aribisala B, Bastin ME, Bauer M, Bearden CE, Bergmann O, Binder EB, Blangero J, Bockholt HJ, Bøen E, Bois C, Boomsma DI, Booth T, Bowman IJ, Bralten J, Brouwer RM, Brunner HG, Brohawn DG, Buckner RL, Buitelaar J, Bulayeva K, Bustillo JR, Calhoun VD, Cannon DM, Cantor RM, Carless MA, Caseras X, Cavalleri GL, Chakravarty MM, Chang KD, Ching CRK, Christoforou A, Cichon S, Clark VP, Conrod P, Coppola G, Crespo-Facorro B, Curran JE, Czisch M, Deary IJ, de Geus EJC, den Braber A, Delvecchio G, Depondt C, de Haan L, de Zubicaray GI, Dima D, Dimitrova R, Djurovic S, Dong H, Donohoe G, Duggirala R, Dyer TD, Ehrlich S, Ekman CJ, Elvsåshagen T, Emsell L, Erk S, Espeseth T, Fagerness J, Fears S, Fedko I, Fernández G, Fisher SE, Foroud T, Fox PT, Francks C, Frangou S, Frey EM, Frodl T, Frouin V, Garavan H, Giddaluru S, Glahn DC, Godlewska B, Goldstein RZ, Gollub RL, Grabe HJ, Grimm O, Gruber O, Guadalupe T, Gur RE, Gur RC, Göring HHH, Hagenaars S, Hajek T, Hall GB, Hall J, Hardy J, Hartman CA, Hass J, Hatton SN, Haukvik UK, Hegenscheid K, Heinz A, Hickie IB, Ho BC, Hoehn D, Hoekstra PJ, Hollinshead M, Holmes AJ, Homuth G, Hoogman M, Hong LE, Hosten N, Hottenga JJ, Hulshoff Pol HE, Hwang KS, Jack CR Jr, Jenkinson M, Johnston C, Jönsson EG, Kahn RS, Kasperaviciute D, Kelly S, Kim S, Kochunov P, Koenders L, Krämer B, Kwok JBJ, Lagopoulos J, Laje G, Landen M, Landman BA, Lauriello J, Lawrie SM, Lee PH, Le Hellard S, Lemaître H, Leonardo CD, Li CS, Liberg B, Liewald DC, Liu X, Lopez LM, Loth E, Lourdusamy A, Luciano M, Macciardi F, Machielsen MWJ, Macqueen GM, Malt UF, Mandl R, Manoach DS, Martinot JL, Matarin M, Mather KA, Mattheisen M, Mattingsdal M, Meyer-Lindenberg A, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meisenzahl E, Melle I, Milaneschi Y, Mohnke S, Montgomery GW, Morris DW, Moses EK, Mueller BA, Muñoz Maniega S, Mühleisen TW, Müller-Myhsok B, Mwangi B, Nauck M, Nho K, Nichols TE, Nilsson LG, Nugent AC, Nyberg L, Olvera RL, Oosterlaan J, Ophoff RA, Pandolfo M, Papalampropoulou-Tsiridou M, Papmeyer M, Paus T, Pausova Z, Pearlson GD, Penninx BW, Peterson CP, Pfennig A, Phillips M, Pike GB, Poline JB, Potkin SG, Pütz B, Ramasamy A, Rasmussen J, Rietschel M, Rijpkema M, Risacher SL, Roffman JL, Roiz-Santiañez R, Romanczuk-Seiferth N, Rose EJ, Royle NA, Rujescu D, Ryten M, Sachdev PS, Salami A, Satterthwaite TD, Savitz J, Saykin AJ, Scanlon C, Schmaal L, Schnack HG, Schork AJ, Schulz SC, Schür R, Seidman L, Shen L, Shoemaker JM, Simmons A, Sisodiya SM, Smith C, Smoller JW, Soares JC, Sponheim SR, Sprooten E, Starr JM, Steen VM, Strakowski S, Strike L, Sussmann J, Sämann PG, Teumer A, Toga AW, Tordesillas-Gutierrez D, Trabzuni D, Trost S, Turner J, van den Heuvel M, van der Wee NJ, van Eijk K, van Erp TGM, van Haren NEM, van 't Ent D, van Tol MJ, Valdés Hernández MC, Veltman DJ, Versace A, Völzke H, Walker R, Walter H, Wang L, Wardlaw JM, Weale ME, Weiner MW, Wen W, Westlye LT, Whalley HC, Whelan CD, White T, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Zilles D, Zwiers MP, Thalamuthu A, Schofield PR, Freimer NB, Lawrence NS, Drevets W, The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. BRAIN IMAGING BEHAV 2014;8 (2):153-182 [PubMed]
Peters BD, Machielsen MWJ, Hoen WP, Caan MWA, Malhotra AK, Szeszko PR, Duran M, Olabarriaga SD, de Haan L, Polyunsaturated fatty acid concentration predicts myelin integrity in early-phase psychosis. SCHIZOPHRENIA BULL 2013;39 (4):830-838 [PubMed]
Machielsen M, Scheltema Beduin A, Dekker N, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I, Differences in craving for cannabis between schizophrenia patients using risperidone, olanzapine or clozapine. J PSYCHOPHARMACOL 2012;26 (1):189-195 [PubMed]
Scheltema Beduin AA, Swets M, Machielsen M, Korver N [Contributors: Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I]] , Obsessive-Compulsive Symptoms in Patients With Schizophrenia: A Naturalistic Cross-Sectional Study Comparing Treatment With Clozapine, Olanzapine, Risperidone, and No Antipsychotics in 543 Patients. J CLIN PSYCHIAT 2012;73 (11):1395-1402 [PubMed]
van der Meer FJ, Velthorst E, Meijer CJ, Machielsen MWJ, de Haan L, Cannabis Use in Patients at Clinical High Risk of Psychosis: Impact on Prodromal Symptoms and Transition to Psychosis. CURR PHARM DESIGN 2012;18 (32):5036-5044 [PubMed]
Machielsen M, van der Sluis S, de Haan L, Cannabis use in patients with a first psychotic episode and subjects at ultra high risk of psychosis: impact on psychotic and pre-psychotic symptoms. AUST NZ J PSYCHIAT 2010;44 (8):721-728 [PubMed]
Machielsen MWJ, de Haan L, Differences in efficacy on substance abuse between risperidone and clozapine supports the importance of differential modulation of dopaminergic neurotransmission. PSYCHOPHARMACOL BULL 2009;42 (4):40-52 [PubMed]
Key publications

Machielsen M, Scheltema Beduin A, Dekker N, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I, Differences in craving for cannabis between schizophrenia patients using risperidone, olanzapine or clozapine. J PSYCHOPHARMACOL 2012;26 (1):189-195 [PubMed]
Machielsen M, van der Sluis S, de Haan L, Cannabis use in patients with a first psychotic episode and subjects at ultra high risk of psychosis: impact on psychotic and pre-psychotic symptoms. AUST NZ J PSYCHIAT 2010;44 (8):721-728 [PubMed]


All Publications

Research programmes

Prof. dr. L. de Haan (Recent onset schizophrenia)

Other research related activities
  • None reported
Current research funding
  • None reported