Researchers

  • Female

Drs. F. da Silva Alves

Position: PhD student
Main activities: Research
Specialisation: Brain Imaging in Psychosis
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Focus of research:

My work focuses upon elucidating neurobiological substrates involved in the development of psychosis. I study different aspects of brain structure and function as well as neurotransmitters and metabolism in patients with 22q11 deletion syndrome (22q11DS) and in patients with schizophrenia. I investigate brain metabolism (i.e. glutamate, glutamine, myo-inositol), white mater integrity in the 22q11DS and its association with susceptibility to schizophrenia. For these studies I use magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), voxel based morphormetry (VBM). I also employed pharmacological magnetic resonance imaging (PhMRI) to study the effects of dopamine depletion on neuronal pathways underlying motivation and reward-related behaviour in healthy individuals and in people with schizophrenia.

 

AMC themes: Neurological & Psychiatric Disorders
Departments: Psychiatry: Adult Psychiatry
van Duin EDA, Goossens L, Hernaus D, da Silva Alves F, Schmitz N, Schruers K, van Amelsvoort T, Erratum to: Neural correlates of reward processing in adults with 22q11 deletion syndrome. J NEURODEV DISORD 2016;8:31 [PubMed]
van Duin EDA, Goossens L, Hernaus D, da Silva Alves F, Schmitz N, Schruers K, van Amelsvoort T, Neural correlates of reward processing in adults with 22q11 deletion syndrome. J NEURODEV DISORD 2016;8:25 [PubMed]
Evers LJM, Curfs LMG, Bakker JA, Boot E, da Silva Alves F, Abeling N, Bierau J, Drukker M, van Amelsvoort TAMJ, Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome. INT J NEUROPSYCHOPH 2014;17 (8):1159-1165 [PubMed]
da Silva Alves F, Bakker G, Schmitz N, Abeling N, Hasler G, van der Meer J, Nederveen A, de Haan L, Linszen D, van Amelsvoort T, Dopaminergic modulation of the reward system in schizophrenia: a placebo-controlled dopamine depletion fMRI study. EUR NEUROPSYCHOPHARM 2013;23 (11):1577-1586 [PubMed]
da Silva Alves F. Challenges of brain imaging in psychiatry: understanding brain structure and function in schizophrenia. s.l.: s.n.; 2012. 171p. ISBN 978909026793 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Linszen DH, van Amelsvoort TAMJ; copromotor(s): Schmitz N)
Bloemen OJN, Gleich T, de Koning MB, da Silva Alvis F, de Haan L, Linszen DH, Booij J, van Amelsvoort TAMJ, Hippocampal glutamate levels and striatal dopamine D(2/3) receptor occupancy in subjects at ultra high risk of psychosis. BIOL PSYCHIAT 2011;70 (1):e1-2; author reply e3 [PubMed]
Boot E, Booij J, Abeling N, Meijer J, da Silva Alves F, Zinkstok J, Baas F, Linszen D, van Amelsvoort T, Dopamine metabolism in adults with 22q11 deletion syndrome, with and without schizophrenia--relationship with COMT Val¹⁰⁸/¹⁵⁸Met polymorphism, gender and symptomatology. J PSYCHOPHARMACOL 2011;25 (7):888-895 [PubMed]
da Silva Alves F, Boot E, Schmitz N, Nederveen A, Vorstman J, Lavini C, Pouwels PJ, Pouwels P, de Haan L, Linszen D, van Amelsvoort T, Proton magnetic resonance spectroscopy in 22q11 deletion syndrome. PLOS ONE 2011;6 (6):e21685 [PubMed]
da Silva Alves F, Schmitz N, Bloemen O, van der Meer J, Meijer J, Boot E, Nederveen A, de Haan L, Linszen D, van Amelsvoort T, White matter abnormalities in adults with 22q11 deletion syndrome with and without schizophrenia. SCHIZOPHR RES 2011;132 (1):75-83 [PubMed]
da Silva Alves F, Schmitz N, Figee M, Abeling N, Hasler G, van der Meer J, Nederveen A, de Haan L, Linszen D, van Amelsvoort T, Dopaminergic modulation of the human reward system: a placebo-controlled dopamine depletion fMRI study. J PSYCHOPHARMACOL 2011;25 (4):538-549 [PubMed]
da Silva Alves F, Figee M, van Amelsvoort T, Veltman D, de Haan L, The revised dopamine hypothesis of schizophrenia: evidence from pharmacological MRI studies with atypical antipsychotic medication. PSYCHOPHARMACOL BULL 2008;41 (1):121-132 [PubMed]
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