Researchers

  • Principal Investigator
  • Male

Prof. dr. D.A.J.P. Denys

Position: Professor
Main activities: Research, Patient care
Specialisation: Psychiatry
foto D.A.J.P. Denys is one of the AMC Principal Investigators
Focus of research:

Since my employment as PhD student at the University of Utrecht my research focused on obsessive compulsive (spectrum) disorders. OCD was approached from diverse perspectives by means of different methodological tools. One perspective covers OCD from clinical viewpoint and inquires its nosological status. Is OCD a discrete psychiatric disorder or does it represent different clinical subtypes? Another part encompasses randomized clinical trials and aimed to contribute to the pharmacological management of OCD. Is switching drugs in case of non-response to treatment a useful strategy for patients with OCD? Can we identify clinical characteristics that predict a favorable treatment response with pharmacotherapy? Is addition of an atypical antipsychotic to a serotonergic reuptake inhibitor beneficial for treatment-resistant OCD patients? Another perspective addresses OCD from etiological perspective and investigates the role of neurotransmitters in OCD. What is the effect of the combination of an atypical antipsychotic to a serotonergic reuptake inhibitor on dopamine and serotonin levels in different (rat) brain areas? Can we find in vivo evidence for the involvement of the dopamine system in OCD through imaging-studies? Is there an association between specific genotypes of dopamine or serotonergic genes and OCD? Currently, my research focuses on the applicability of deep brain stimulation in OCD and psychiatric disorders.

AMC themes: Neurological & Psychiatric Disorders
Departments: Psychiatry: Adult Psychiatry
Bergfeld IO, Mantione M, Hoogendoorn MLC, Horst F, Notten P, Schuurman PR, Denys D, Episodic memory following deep brain stimulation of the ventral anterior limb of the internal capsule and electroconvulsive therapy. BRAIN STIMUL 2017;10 (5):959-966 [PubMed]
Bergfeld IO, Mantione M, Hoogendoorn MLC, Ruhé HG, Horst F, Notten P, van Laarhoven J, van den Munckhof P, Beute G, Schuurman PR, Denys D, Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression. PSYCHOL MED 2017;47 (9):1647-1658 [PubMed]
Blom RM. Studies in obsessive-compulsive disorder (OCD) and body integrity identity disorder (BIID). S.l.: s.n.; 2017. 185p. ISBN 978-94-028-0716-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP; copromotor(s): Vulink NCC)
Blom RM, van der Wal SJ, Vulink NC, Denys D, Role of Sexuality in Body Integrity Identity Disorder (BIID): A Cross-Sectional Internet-Based Survey Study. J SEX MED 2017;14 (8):1028-1035 [PubMed]
Boedhoe PSW, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C , Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YCJ, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson PM, Stein DJ, van den Heuvel OA, Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. AM J PSYCHIAT 2017;174 (1):60-69 [PubMed]
de Haan S, Rietveld E, Stokhof M, Denys D, Becoming more oneself? Changes in personality following DBS treatment for psychiatric disorders: Experiences of OCD patients and general considerations. PLOS ONE 2017;12 (4):e0175748 [PubMed]
dell'Osso B, Benatti B, Arici C, Palazzo C, Altamura AC, Hollander E, Fineberg N, Stein DJ, Nicolini H, Lanzagorta N, Marazziti D, Pallanti S, van Ameringen M, Lochner C, Karamustafalioglu O, Hranov L, Figee M, Drummond L, Rodriguez CI, Grant J, Denys D, Menchon JM, Zohar J, Prevalence of suicide attempt and clinical characteristics of suicide attempters with obsessive-compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS). CNS SPECTRUMS 2017;ahead of print [PubMed]
Dell'Osso B, Benatti B, Rodriguez CI, Arici C, Palazzo C, Altamura AC, Hollander E, Fineberg N, Stein DJ, Nicolini H, Lanzagorta N, Marazziti D, Pallanti S, van Ameringen M, Lochner C, Karamustafalioglu O, Hranov L, Figee M, Drummond L, Grant J, Denys D, Cath D, Menchon JM, Zohar J, Obsessive-compulsive disorder in the elderly: A report from the International College of Obsessive-Compulsive Disorders (ICOCS). EUR PSYCHIAT 2017;45:36-40 [PubMed]
Graat I, Figee M, Denys D, The application of deep brain stimulation in the treatment of psychiatric disorders. INT REV PSYCHIATR 2017;29 (2):178-190 [PubMed]
Hofmeijer-Sevink MK, Duits P, Rijkeboer MM, Hoogendoorn AW, van Megen HJ, Vulink NC, Denys DA, van den Hout MA, van Balkom AJ, Cath DC, No Effects of D-Cycloserine Enhancement in Exposure With Response Prevention Therapy in Panic Disorder With Agoraphobia A Double-Blind, Randomized Controlled Trial. J CLIN PSYCHOPHARM 2017;37 (5):531-539 [PubMed]
Klanker M, Feenstra M, Willuhn I, Denys D, Deep brain stimulation of the medial forebrain bundle elevates striatal dopamine concentration without affecting spontaneous or reward-induced phasic release. NEUROSCIENCE 2017;ahead of print [PubMed]
Klanker M, Fellinger L, Feenstra M, Willuhn I, Denys D, REGIONALLY DISTINCT PHASIC DOPAMINE RELEASE PATTERNS IN THE STRIATUM DURING REVERSAL LEARNING. NEUROSCIENCE 2017;345:110-123 [PubMed]
Klink PC, Boucherie D, Denys D, Roelfsema PR, Self MW, Interocularly merged face percepts eliminate binocular rivalry. SCI REP-UK 2017;7 (1):7585 [PubMed]
Klink PC, Jeurissen D, Theeuwes J, Denys D, Roelfsema PR, Working memory accuracy for multiple targets is driven by reward expectation and stimulus contrast with different time-courses. SCI REP-UK 2017;7 (1):9082 [PubMed]
Korte SM, Prins J, van den Bergh FS, Oosting RS, Dupree R, Korte-Bouws GAH, Westphal KGC, Olivier B, Denys DA, Garland A, Güntürkün O, The 5-HT1A/1B-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and "waiting" impulsivity, but increases "stopping" impulsivity. EUR J PHARMACOL 2017;794:257-269 [PubMed]
Levar N, van Leeuwen JMC, Denys D, van Wingen GA, Divergent influences of anterior cingulate cortex GABA concentrations on the emotion circuitry. NEUROIMAGE 2017;158:136-144 [PubMed]
Levar N, van Leeuwen JMC, Puts NAJ, Denys D, van Wingen GA, GABA Concentrations in the Anterior Cingulate Cortex Are Associated with Fear Network Function and Fear Recovery in Humans. FRONT HUM NEUROSCI 2017;11:202 [PubMed]
Linssen RSN, Oudijn MS, Mantione M, van den Munckhof P, Denys D, Schuurman PR, Body Weight Changes after Deep Brain Stimulation for Obsessive-Compulsive Disorder or Depression. STEREOT FUNCT NEUROS 2017;95 (5):348-351 [PubMed]
Mattila T, Koeter M, Wohlfarth T, Storosum J, van den Brink W, Derks E, Leufkens H, Denys D, The impact of second generation antipsychotics on insight in schizophrenia: Results from 14 randomized, placebo controlled trials. EUR NEUROPSYCHOPHARM 2017;27 (1):82-86 [PubMed]
Ooms P, Blankers M, Figee M, Bergfeld IO, van den Munckhof P, Schuurman PR, Denys D, Cost-effectiveness of deep brain stimulation versus treatment as usual for obsessive-compulsive disorder. BRAIN STIMUL 2017;10 (4):836-842 [PubMed]
Schippers MC, Bruinsma B, Gaastra M, Mesman TI, Denys D, de Vries TJ, Pattij T, Deep Brain Stimulation of the Nucleus Accumbens Core Affects Trait Impulsivity in a Baseline-Dependent Manner. FRONT BEHAV NEUROSCI 2017;11:52 [PubMed]
Schröder AE, Vulink NC, van Loon AJ, Denys DA, Cognitive behavioral therapy is effective in misophonia: An open trial. J AFFECT DISORDERS 2017;217:289-294 [PubMed]
Schroder A, van Wingen G, Vulink NC, Denys D, Commentary: The Brain Basis for Misophonia. FRONT BEHAV NEUROSCI 2017;11:111
Slagter HA, Mazaheri A, Reteig LC, Smolders R, Figee M, Mantione M, Schuurman PR, Denys D, Contributions of the Ventral Striatum to Conscious Perception: An Intracranial EEG Study of the Attentional Blink. J NEUROSCI 2017;37 (5):1081-1089 [PubMed]
van Bennekom MJ, de Koning PP, Denys D, Virtual Reality Objectifies the Diagnosis of Psychiatric Disorders: A Literature Review. FRONT PSYCHIATRY 2017;8:163 [PubMed]
van Rooijen G, Strypet M, Maat A, Scheepens DS, Oudijn MS, Klopper KE , Denys D, Early introduction of clozapine after neuroleptic malignant syndrome may prevent malignant catatonia: A case report. EUR NEUROPSYCHOPHARM 2017;27 (1):91-92 [PubMed]
Bahramisharif A , Mazaheri A, Levar N, Richard Schuurman P, Figee M, Denys D, Deep Brain Stimulation Diminishes Cross-Frequency Coupling in Obsessive-Compulsive Disorder. BIOL PSYCHIAT 2016;80 (7):E57-E58 [PubMed]
Bergfeld IO, Mantione M, Hoogendoorn MLC, Ruhé HG , Notten P, van Laarhoven J, Visser I , Figee M, de Kwaasteniet BP, Horst F, Schene AH, van den Munckhof P, Beute G, Schuurman R, Denys D, Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Treatment-Resistant Depression: A Randomized Clinical Trial. JAMA PSYCHIAT 2016;73 (5):456-464 [PubMed]
Blom RM, Guglielmi V, Denys D, Elective amputation of a "healthy limb". CNS SPECTRUMS 2016;21 (5):360-361 [PubMed]
Blom RM, van Wingen GA, van der Wal SJ, Luigjes J, van Dijk MT, Scholte HS, Denys D, The Desire for Amputation or Paralyzation: Evidence for Structural Brain Anomalies in Body Integrity Identity Disorder (BIID). PLOS ONE 2016;11 (11):e0165789 [PubMed]
Blom RM, Vulink NC, van der Wal SJ, Nakamae T, Tan Z, Derks EM, Denys D, Body integrity identity disorder crosses culture: case reports in the Japanese and Chinese literature. NEUROPSYCH DIS TREAT 2016;12:1419-1423 [PubMed]
Deeb W, Giordano JJ, Rossi PJ, Mogilner AY, Gunduz A, Judy JW, Klassen BT, Butson CR, van Horne C, Deny D, Dougherty DD, Rowell D, Gerhardt GA, Smith GS, Ponce FA, Walker HC, Bronte-Stewart HM, Mayberg HS, Chizeck HJ, Langevin JP, Volkmann J, Ostrem JL, Shute JB, Jimenez-Shahed J, Foote KD, Wagle Shukla A, Rossi MA, Oh M, Pourfar M, Rosenberg PB, Silburn PA, de Hemptine C, Starr PA, Denison T, Akbar U, Grill WM, Okun MS, Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies. FRONT INTEGR NEUROSCI 2016;10:38 [PubMed]
de Koning PP. Rapid mechanisms of DBS in OCD. S.l.: s.n.; 2016. 179p. ISBN 978-94-6295-497-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP; copromotor(s): Storosum JG, Figee M)
de Koning PP, Figee M, Endert E, van den Munckhof P, Schuurman PR, Storosum JG, Denys D, Fliers E, Rapid effects of deep brain stimulation reactivation on symptoms and neuroendocrine parameters in obsessive-compulsive disorder. TRANSL PSYCHIAT 2016;6:e722 [PubMed]
dell'Osso B, Benatti B, Hollander E, Fineberg N, Stein DJ, Lochner C, Nicolini H, Lanzagorta N, Palazzo C, Altamura AC, Marazziti D, Pallanti S, van Ameringen M, Karamustafalioglu O, Drummond LM, Hranov L, Figee M, Grant JE, Zohar J, Denys D, Menchon JM, Childhood, adolescent and adult age at onset and related clinical correlates in obsessive-compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS). INT J PSYCHIAT CLIN 2016;20 (4):210-217 [PubMed]
Feenstra MGP, Klompmakers A, Figee M, Fluitman S, Vulink N, Westenberg HGM, Denys D, Prazosin addition to fluvoxamine: A preclinical study and open clinical trial in OCD. EUR NEUROPSYCHOPHARM 2016;26 (2):310-319 [PubMed]
Figee M, Pattij T, Willuhn I, Luigjes J, van den Brink W, Goudriaan A, Potenza MN, Robbins TW, Denys D, Compulsivity in obsessive-compulsive disorder and addictions. EUR NEUROPSYCHOPHARM 2016;26 (5):856-868 [PubMed]
Giffin M, Figee M, Denys D. Deep brain stimulation for the treatment of obsessive-compulsive disorder in: Hamani C, Holtzheimer P, Lozano AM, Mayberg H, editors. Neuromodulation in Psychiatry. S.l.: John Wiley & Sons; 2016., p. 295
Klanker M. Neuromodulation in corticostriatal circuits: On deep brain stimulation and dopamine. S.l.: s.n.; 2016. 182p. ISBN 978-94-028-0170-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP; copromotor(s): Feenstra MGP, Willuhn I)
Kohl S, Baldermann JC, Denys D, Kuhn J, A Synergistic Treatment Strategy for Severe Obsessive Compulsive Disorder. NEUROMODULATION 2016;19 (5):542-544 [PubMed]
Luigjes J, Figee M, Tobler PN, van den Brink W, de Kwaasteniet B, van Wingen G, Denys D, Doubt in the Insula: Risk Processing in Obsessive-Compulsive Disorder. FRONT HUM NEUROSCI 2016;10:283 [PubMed]
Mattila T. Bridging from drug registration trials to meaningful clinical evidence: The case of schizophrenia. S.l.: s.n.; 2016. 116p. ISBN 978-9462-954-47-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP, Leufkens HGM; copromotor(s): )
Menchón JM, van Ameringen M, dell'Osso B, Denys D, Figee M, Grant JE, Hollander E, Marazziti D, Nicolini H, Pallanti S, Ruck C, Shavitt R, Stein DJ, Andersson E, Bipeta R, Cath DC, Drummond L, Feusner J, Geller DA, Hranov G, Lochner C, Matsunaga H, McCabe RE, Mpavaenda D, Nakamae T, O'Kearney R, Pasquini M, Pérez Rivera R, Poyurovsky M, Real E, do Rosário MC, Soreni N, Swinson RP, Vulink N, Zohar J, Fineberg N, Standards of care for obsessive-compulsive disorder centres. INT J PSYCHIAT CLIN 2016;20 (3):204-208 [PubMed]
Stringer S, Denys D, Kahn RS, Derks EM, What Cure Models Can Teach us About Genome-Wide Survival Analysis. BEHAV GENET 2016;46 (2):269-280 [PubMed]
Subirà M, Cano M, de Wit SJ, Alonso P, Cardoner N, Hoexter MQ, Kwon JS, Nakamae T, Lochner C, Sato JR, Jung WH, Narumoto J, Stein DJ, Pujol J, Mataix-Cols D, Veltman DJ, Menchón JM, van den Heuvel OA, Soriano-Mas C [Contributors: Busatto GF, Cath DC, Denys D, Fukui K, Fouche JP, Jang JH, Kim SN, Miguel EC, Nishida S, Phillips ML, Remijnse PL, Sakai Y, Schweren L, Shin NY, Yamada K]] , Structural covariance of neostriatal and limbic regions in patients with obsessive-compulsive disorder. J PSYCHIATR NEUROSCI 2016;41 (2):115-123 [PubMed]
van den Heuvel OA, van Wingen G, Soriano-Mas C, Alonso P, Chamberlain SR, Nakamae T, Denys D, Goudriaan AE, Veltman DJ, Brain circuitry of compulsivity. EUR NEUROPSYCHOPHARM 2016;26 (5):810-827 [PubMed]
van Rooijen G, Denys D, Fliers E, Nieuwdorp M, Effective Electroconvulsive Therapy in a Patient With Psychotic Depression With Active Cushing Disease. J ECT 2016;32 (3):e20-e21 [PubMed]
Vulink NC, Planting RS, Figee M, Booij J, Denys D, Reduced striatal dopamine D2/3 receptor availability in Body Dysmorphic Disorder. EUR NEUROPSYCHOPHARM 2016;26 (2):350-356 [PubMed]
Welten CCM. Drug treatment for patients with acute mania: Understanding clinical trials and treatment success. S.l.: s.n.; 2016. 171p. ISBN 978-94-6295-297-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP, Leufkens HGM; copromotor(s): Koeter MWJ, Wohlfarth TD)
Welten CCM, Koeter MWJ, Wohlfarth TD, Storosum JG, van den Brink W, Gispen-de Wied CC, Leufkens HGM, Denys DAJP, Does Insight Affect the Efficacy of Antipsychotics in Acute Mania?: An Individual Patient Data Regression Meta-Analysis. J CLIN PSYCHOPHARM 2016;36 (1):71-76 [PubMed]
Welten CCM, Koeter MWJ, Wohlfarth TD, Storosum JG, van den Brink W, Gispen-de Wied CC, Leufkens HGM, Denys DAJP, Early Nonresponse in the Antipsychotic Treatment of Acute Mania: A Criterion for Reconsidering Treatment? Results From an Individual Patient Data Meta-Analysis. J CLIN PSYCHIAT 2016;77 (9):e1117-e1123 [PubMed]
Zantvoord JB , Vulink N, Denys D, Cognitive Behavioral Therapy for Olfactory Reference Syndrome: A Case Report. J CLIN PSYCHIAT 2016;77 (9):E1144-E1145 [PubMed]
Alonso P, Cuadras D, Gabriëls L, Denys D, Goodman W, Greenberg BD, Jimenez-Ponce F, Kuhn J, Lenartz D, Mallet L, Nuttin B, Real E, Segalas C, Schuurman R, du Montcel ST, Menchon JM, Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response. PLOS ONE 2015;10 (7):e0133591 [PubMed]
de Haan S, Rietveld E, Stokhof M, Denys D, Effects of Deep Brain Stimulation on the Lived Experience of Obsessive-Compulsive Disorder Patients: In-Depth Interviews with 18 Patients. PLOS ONE 2015;10 (8):e0135524 [PubMed]
de Kwaasteniet BP. Neurobiological mechanisms of treatment resistant depression: Functional, structural and molecular imaging studies. S.l.: s.n.; 2015. 185p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys D; copromotor(s): Ruhé E, van Wingen G)
de Kwaasteniet BP, Pinto C, Ruhé HG , van Wingen GA, Booij J, Denys D, Striatal Dopamine D-2/3 Receptor Availability in Treatment Resistant Depression (vol 9, e113612, 2014). PLOS ONE 2015;10 (8):e0135764 [PubMed]
de Kwaasteniet BP, Rive MM, Ruhé HG , Schene AH, Veltman DJ, Fellinger L, van Wingen GA, Denys D, Decreased resting-state connectivity between neurocognitive networks in treatment resistant depression. FRONT PSYCHIATRY 2015;6:28 [PubMed]
dell'Osso B, Nicolini H, Lanzagorta N, Benatti B, Spagnolin G, Palazzo MC, Marazziti D, Hollander E, Fineberg N, Stein DJ, Pallanti S, van Ameringen M, Lochner C, Hranov G, Karamustafalioglu O, Hranov L, Zohar J, Denys D, Altamura AC, Menchon JM, Cigarette smoking in patients with obsessive compulsive disorder: a report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS). CNS SPECTRUMS 2015;20 (5):469-473 [PubMed]
Denys D. Voorwoord in: Milders F, Thunnissen M, editors. Psychotherapeutische psychiatrie. Menselijk maat in praktijk en wetenschap. Utrecht: De Tijdstroom; 2015., p. 7-10
Figee M, Schuurman R, Denys D, Challenges with Meta-Analysis in Deep Brain Stimulation. STEREOT FUNCT NEUROS 2015;93 (2):147 [PubMed]
Franken I, Muris P, Denys D, editors, Psychopathologie. Oorzaken, diagnostiek en behandeling. (tweede druk). Utrecht: de Tijdstroom; 2015. 969p. ISBN 9789058982773
Gobin V. Teaching old drugs new tricks: selective serotonin reuptake inhibitors as a novel class of immunosuppressants. S.l.: s.n.; 2015. 177p. Proefschrift Ghent University, Belgium, Faculty of Pharmaceutical Sciences. (Promotor(s): Deforce D; copromotor(s): Denys D, Van Steendam K)
Grassi G, Pallanti S, Righi L, Figee M, Mantione M, Denys D, Piccagliani D, Rossi A, Stratta P, Think twice: Impulsivity and decision making in obsessive-compulsive disorder. J BEHAV ADDICT 2015;4 (4):263-272 [PubMed]
Horschig JM, Smolders R, Bonnefond M, Schoffelen JM, van den Munckhof P, Schuurman PR, Cools R, Denys D, Jensen O, Directed Communication between Nucleus Accumbens and Neocortex in Humans Is Differentially Supported by Synchronization in the Theta and Alpha Band. PLOS ONE 2015;10 (9):e0138685 [PubMed]
Klanker M, Sandberg T, Joosten R, Willuhn I, Feenstra M, Denys D, Phasic dopamine release induced by positive feedback predicts individual differences in reversal learning. NEUROBIOL LEARN MEM 2015;125:135-145 [PubMed]
Luigjes J. Out of control: Losing oneself in compulsivity. S.l.: s.n.; 2015. 219p. ISBN 978-94-6295-215-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP, van den Brink W; copromotor(s): van Wingen GA)
Luigjes J, van den Brink W, Schuurman PR, Kuhn J, Denys D, Is deep brain stimulation a treatment option for addiction?. ADDICTION 2015;110 (4):547-548 [PubMed]
Mantione MHM. The stimulated brain: A psychological perspective on deep brain stimulation for treatment-refractory obsessive-compulsive disorder. S.l.: s.n.; 2015. 179p. ISBN 978-94-6295-135-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP; copromotor(s): Nieman DH)
Mantione M, Nieman D, Figee M, van den Munckhof P, Schuurman R, Denys D, Cognitive effects of deep brain stimulation in patients with obsessive-compulsive disorder. J PSYCHIATR NEUROSCI 2015;40 (6):378-386 [PubMed]
Mattila T, Koeter M, Wohlfarth T, Storosum J, van den Brink W, de Haan L, Derks E, Leufkens H, Denys D, Impact of DSM-5 changes on the diagnosis and acute treatment of schizophrenia. SCHIZOPHRENIA BULL 2015;41 (3):637-643 [PubMed]
Prosée R, Denys D. Psychiatric Indications for Deep Brain Stimulation in: Reti I, editor. Brain Stimulation: Methodologies and Interventions. S.l.: Wiley-Blackwell; 2015., p. 289-304
Prosée R, Vulink N, Denys D. Obsessieve-compulsieve stoornis, inclusief verzamelstoornis in: Franken I, Muris P, Denys D, editors. Psychopathologie. Oorzaken, diagnostiek en behandeling. (tweede druk). Utrecht: de Tijdstroom; 2015., p. 337-358
Rosaura Polak A, Witteveen AB, Denys D, Olff M, Breathing biofeedback as an adjunct to exposure in cognitive behavioral therapy hastens the reduction of PTSD symptoms: a pilot study. APPL PSYCHOPHYS BIOF 2015;40 (1):25-31 [PubMed]
Stringer S. Breaking the code: Statistical methods and methodological issues in psychiatric genetics. S.l.: s.n.; 2015. 236p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Derks EM, Kahn RS; copromotor(s): Denys DAJP)
Stringer S, Cerrone KC, van den Brink W, van den Berg JF, Denys D, Kahn RS, Derks EM, A guide on gene prioritization in studies of psychiatric disorders. INT J METH PSYCH RES 2015;24 (4):245-256 [PubMed]
van Bennekom MJ, Blom RM, Vulink N, Denys D, A case of digital hoarding. BMJ CASE REP 2015;2015:bcr2015210814 [PubMed]
van Diepen RM, Cohen MX, Denys D, Mazaheri A, Attention and temporal expectations modulate power, not phase, of ongoing alpha oscillations. J COGNITIVE NEUROSCI 2015;27 (8):1573-1586 [PubMed]
van Waarde JA, Scholte HS, van Oudheusden LJB, Verwey B, Denys D, van Wingen GA, A functional MRI marker may predict the outcome of electroconvulsive therapy in severe and treatment-resistant depression. MOL PSYCHIATR 2015;20 (5):609-614 [PubMed]
van Westen M, Rietveld E, Figee M, Denys D, Clinical Outcome and Mechanisms of Deep Brain Stimulation for Obsessive-Compulsive Disorder. CURR BEHAV NEUROSCI REP 2015;2 (2):41-48 [PubMed]
Welten CCM, Koeter MWJ, Wohlfarth TD, Storosum JG, van den Brink W, Gispen-de Wied CC, Leufkens HGM, Denys DAJP, Efficacy of drug treatment for acute mania differs across geographic regions: An individual patient data meta-analysis of placebo-controlled studies. J PSYCHOPHARMACOL 2015;29 (8):923-932 [PubMed]
Welten CCM, Koeter MWJ, Wohlfarth TD, Storosum JG, van den Brink W, Gispen-de Wied CC, Leufkens HGM, Denys DAJP, Net gain analysis, an addition to responder analysis - The case of antipsychotic treatment of acute mania. REGUL TOXICOL PHARM 2015;73 (1):227-231 [PubMed]
Welten CCM, Koeter MWJ, Wohlfarth T, Storosum JG, van den Brink W, Gispen-de Wied CC, Leufkens HGM, Denys DAJP, Placebo response in antipsychotic trials of patients with acute mania: Results of an individual patient data meta-analysis. EUR NEUROPSYCHOPHARM 2015;25 (7):1018-1026 [PubMed]
Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JCC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SMJ, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-Vanderweele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HGM, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL, Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. AM J PSYCHIAT 2015;172 (1):82-93 [PubMed]
Aleman A, Denys D, A road map for suicide research and prevention. NATURE 2014;509 (7501):421-423 [PubMed]
Baas JMP, Klumpers F, Mantione MH, Figee M, Vulink NC, Schuurman PR, Mazaheri A, Denys D, No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder. FRONT BEHAV NEUROSCI 2014;8:305 [PubMed]
Bais M, Figee M, Denys D, Neuromodulation in obsessive-compulsive disorder. PSYCHIAT CLIN N AM 2014;37 (3):393-413 [PubMed]
Bottelier MA, Schouw MLJ, Klomp A, Tamminga HGH, Schrantee AGM, Bouziane C, de Ruiter MB, Boer F, Ruhé HG , Denys D, Rijsman R, Lindauer RJL, Reitsma HB, Geurts HM, Reneman L, The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design. BMC PSYCHIATRY 2014;14 (1):48 [PubMed]
de Haan S, Rietveld E, Denys D, Stimulating Good Practice: What an EEC Approach Could Actually Mean for DBS Practice. AJOB NEUROSCI 2014;5 (4):46-48
de Kwaasteniet BP, Pinto C, Ruhé HG , Ruhé EHG, van Wingen GA, Booij J, Denys D, Striatal dopamine D2/3 receptor availability in treatment resistant depression. PLOS ONE 2014;9 (11):e113612 [PubMed]
Denys D, Compulsivity and free will. CNS SPECTRUMS 2014;19 (1):8-9 [PubMed]
Denys D, Mogen artsen een gezond ledemaat amputeren?. NED TIJDSCHR GENEESKD 2014;158:A7525 [PubMed]
de Wit SJ, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Menchón JM, Stein DJ, Fouche JP, Soriano-Mas C, Sato JR, Hoexter MQ, Denys D, Nakamae T, Nishida S, Kwon JS, Jang JH, Busatto GF, Cardoner N, Cath DC, Fukui K, Jung WH, Kim SN, Miguel EC, Narumoto J, Phillips ML, Pujol J, Remijnse PL, Sakai Y, Shin NY, Yamada K, Veltman DJ, van den Heuvel OA, Multicenter voxel-based morphometry mega-analysis of structural brain scans in obsessive-compulsive disorder. AM J PSYCHIAT 2014;171 (3):340-349 [PubMed]
Figee M, de Koning P, Klaassen S, Vulink N, Mantione M, van den Munckhof P, Schuurman R , van Wingen G, van Amelsvoort T, Booij J, Denys D, Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder. BIOL PSYCHIAT 2014;75 (8):647-652 [PubMed]
Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, Mantione M, Ooms P, de Koning P, Vulink N, Levar N, Droge L, van den Munckhof P, Schuurman PR, Nederveen A, van den Brink W, Mazaheri A, Vink M, Denys D, Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder (vol 16, pg 386, 2013). NAT NEUROSCI 2014;17 (9):1286 [PubMed]
Fineberg NA, Chamberlain SR, Goudriaan AE, Stein DJ, Vanderschuren LJMJ, Gillan CM, Shekar S, Gorwood PAPM, Voon V, Morein-Zamir S, Denys D, Sahakian BJ, Moeller FG, Robbins TW, Potenza MN, New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS SPECTRUMS 2014;19 (1):69-89 [PubMed]
Frijling JL, van Zuiden M, Koch SBJ, Nawijn L, Goslings JC, Luitse JS, Biesheuvel TH, Honig A, Bakker FC, Denys D, Veltman DJ, Olff M, Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial. BMC PSYCHIATRY 2014;14 (1):92 [PubMed]
Gobin V, van Steendam K, Denys D, Deforce D, Selective serotonin reuptake inhibitors as a novel class of immunosuppressants. INT IMMUNOPHARMACOL 2014;20 (1):148-156 [PubMed]
Guglielmi V, Vulink NCC, Denys D, Wang Y, Samuels JF, Nestadt G, Obsessive-compulsive disorder and female reproductive cycle events: results from the OCD and reproduction collaborative study. DEPRESS ANXIETY 2014;31 (12):979-987 [PubMed]
Klomp A, Hamelink R, Feenstra M, Denys D, Reneman L, Increased response to a 5-HT challenge after discontinuation of chronic serotonin uptake inhibition in the adult and adolescent rat brain. PLOS ONE 2014;9 (6):e99873 [PubMed]
Kohl S, Schönherr DM, Luigjes J, Denys D, Mueller UJ, Lenartz D, Visser-Vandewalle V, Kuhn J, Deep brain stimulation for treatment-refractory obsessive compulsive disorder: a systematic review. BMC PSYCHIATRY 2014;14:214 [PubMed]
Lochner C, Fineberg NA, Zohar J, van Ameringen M, Juven-Wetzler A, Altamura AC, Cuzen NL, Hollander E, Denys D, Nicolini H, dell'Osso B, Pallanti S, Stein DJ, Comorbidity in obsessive-compulsive disorder (OCD): a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS). COMPR PSYCHIAT 2014;55 (7):1513-1519 [PubMed]
Mantione M, Figee M, Denys D, A case of musical preference for Johnny Cash following deep brain stimulation of the nucleus accumbens. FRONT BEHAV NEUROSCI 2014;8:152 [PubMed]
Mantione M, Nieman DH, Figee M, Denys D, Cognitive-behavioural therapy augments the effects of deep brain stimulation in obsessive-compulsive disorder. PSYCHOL MED 2014;44 (16):3515-3522 [PubMed]
Mattila T, Wohlfarth T, Koeter M, Storosum J, van den Brink W, de Haan L, Leufkens H, Denys D, Geographic variation in efficacy of atypical antipsychotics for the acute treatment of schizophrenia - an individual patient data meta-analysis. EUR NEUROPSYCHOPHARM 2014;24 (7):1067-1077 [PubMed]
Mazaheri A, van Schouwenburg MR, Dimitrijevic A, Denys D, Cools R, Jensen O, Region-specific modulations in oscillatory alpha activity serve to facilitate processing in the visual and auditory modalities. NEUROIMAGE 2014;87:356-362 [PubMed]
McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SMJ, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM, Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J AM ACAD CHILD PSY 2014;53 (8):910-919 [PubMed]
Nakamae T, Sakai Y, Abe Y, Nishida S, Fukui K, Yamada K, Kubota M, Denys D, Narumoto J, Altered fronto-striatal fiber topography and connectivity in obsessive-compulsive disorder. PLOS ONE 2014;9 (11):e112075 [PubMed]
Olff M, Polak AR, Witteveen AB, Denys D, Executive function in posttraumatic stress disorder (PTSD) and the influence of comorbid depression. NEUROBIOL LEARN MEM 2014;112:114-121 [PubMed]
Ooms P, Blankers M, Figee M, Mantione M, van den Munckhof P, Schuurman PR, Denys D, Rebound of affective symptoms following acute cessation of deep brain stimulation in obsessive-compulsive disorder. BRAIN STIMUL 2014;7 (5):727-731 [PubMed]
Ooms P, de Koning PP, Denys D. Deep brain stimulation in: Emmelkamp P, Ehring T, editors. The Wiley Handbook of Anxiety Disorders. S.l.: Wiley; 2014., p. 1355-1367
Ooms P, Mantione M, Figee M, Schuurman PR, van den Munckhof P, Denys D, Deep brain stimulation for obsessive-compulsive disorders: long-term analysis of quality of life. J NEUROL NEUROSUR PS 2014;85 (2):153-158 [PubMed]
Schröder A, van Diepen R, Mazaheri A, Petropoulos-Petalas D, Soto de Amesti V, Vulink N, Denys D, Diminished Ni auditory evoked poten als to oddball stimuli in misophonia patients. FRONT BEHAV NEUROSCI 2014;8:123 [PubMed]
Sjoerds Z, Luigjes J, van den Brink W, Denys D, Yücel M, The role of habits and motivation in human drug addiction: a reflection. FRONT PSYCHIATRY 2014;5:8 [PubMed]
van Wingen GA, Tendolkar I, Urner M, van Marle H, Denys D, Verkes RJ, Fernández G, Short-term antidepressant administration reduces default mode and task-positive network connectivity in healthy individuals during rest. NEUROIMAGE 2014;88:47-53 [PubMed]
Widdershoven G, Meynen G, Hartman L, Denys D, Ethical Dilemmas in the Practice of DBS. AJOB NEUROSCI 2014;5 (4):83-85
Bergfeld IO, Mantione M, Hoogendoorn MLC, Denys D, Cognitive functioning in psychiatric disorders following deep brain stimulation. BRAIN STIMUL 2013;6 (4):532-537 [PubMed]
Contarino MF, Bot M, Speelman JD, de Bie RMA, Tijssen MA, Denys D, Bour LJ, Schuurman PR, van den Munckhof P, Postoperative displacement of deep brain stimulation electrodes related to lead-anchoring technique. NEUROSURGERY 2013;73 (4):681-8; discussion 188 [PubMed]
Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SMJ, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HGM, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM, Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture. PLOS GENET 2013;9 (10):e1003864 [PubMed]
de Haan S, Rietveld E, Denys D. On the Nature of Obsessions and Compulsions in: Baldwin DS, Leonard BE, editors. Anxiety Disorders. Basel: Karger; 2013. 29, p. 1-15
de Haan S, Rietveld E, Denys D, On the nature of obsessions and compulsions. MOD TRENDS PHARMACOPSYCHIATRI 2013;29:1-15 [PubMed]
de Haan S, Rietveld E, Stokhof M, Denys D, The phenomenology of deep brain stimulation-induced changes in OCD: an enactive affordance-based model. FRONT HUM NEUROSCI 2013;7:653 [PubMed]
de Koning PP, Figee M, Endert E, Storosum JG, Fliers E, Denys D, Deep brain stimulation for obsessive-compulsive disorder is associated with cortisol changes. PSYCHONEUROENDOCRINO 2013;38 (8):1455-1459 [PubMed]
de Kwaasteniet B, Ruhe E , Caan M, Rive M , Olabarriaga S, Groefsema M, Heesink L, van Wingen G, Denys D, Relation between structural and functional connectivity in major depressive disorder. BIOL PSYCHIAT 2013;74 (1):40-47 [PubMed]
Denys D, de Vries F, Cath D, Figee M, Vulink N, Veltman DJ, van der Doef TF, Boellaard R, Westenberg H, van Balkom A, Lammertsma AA, van Berckel BNM, Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder. EUR NEUROPSYCHOPHARM 2013;23 (11):1423-1431 [PubMed]
Diepenbroek C, van der Plasse G, Eggels L, Rijnsburger M, Feenstra MGP, Kalsbeek A, Denys D, Fliers E, Serlie MJ, la Fleur SE, Alterations in blood glucose and plasma glucagon concentrations during deep brain stimulation in the shell region of the nucleus accumbens in rats. FRONT NEUROSCI-SWITZ 2013;7:226 [PubMed]
Figee M. Moving the brain. Neuroimaging motivational changes of deep brain stimulation in obsessive-compulsive disorder. s.l.: s.n.; 2013. 256p. ISBN 9789462282247 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP; copromotor(s): van Wingen GA)
Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, Mantione M, Ooms P, de Koning P, Vulink N, Levar N, Droge L, van den Munckhof P, Schuurman PR, Nederveen A, van den Brink W, Mazaheri A, Vink M, Denys D, Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. NAT NEUROSCI 2013;16 (4):386-387 [PubMed]
Figee M, Wielaard I, Mazaheri A, Denys D, Neurosurgical targets for compulsivity: what can we learn from acquired brain lesions?. NEUROSCI BIOBEHAV R 2013;37 (3):328-339 [PubMed]
Fineberg NA, Baldwin DS, Menchon JM, Denys D, Grünblatt E, Pallanti S, Stein DJ, Zohar J [Contributors: Alonso P, Andreewitch S, Baldwin D, Bellodi L, Bersani G, Cath D, Chamberlain S, Clark L, Craig K, Denys D, dell'Osso B, Eilam D, Fineberg N, Goudriaan Anna E, Grünblatt E, Hermesh H, Heyman I, Hollander E, Hranov G, Hranov L, Ivarsson T, Joel D, Matthews K, Lochner C, Marazziti D, Mataix-Cols D, Menchon J, Noldus L, Pallanti S, Robbins T, Romanos M, Renner T, Rück C, Sahakian B, Stein D, van den Brink W, van den Heuvel O, van der Wee N, Veltman D, Walitza S, Zohar J]] , Manifesto for a European research network into obsessive-compulsive and related disorders. EUR NEUROPSYCHOPHARM 2013;23 (7):561-568 [PubMed]
Gobin V, van Steendam K, Fevery S, Tilleman K, Billiau AD, Denys D, Deforce DL, Fluoxetine Reduces Murine Graft-Versus-Host Disease by Induction of T cell Immunosuppression. J NEUROIMMUNE PHARM 2013;8 (4):934-943 [PubMed]
Klanker M, Feenstra M, Denys D, Dopaminergic control of cognitive flexibility in humans and animals. FRONT NEUROSCI-SWITZ 2013;7:201 [PubMed]
Klanker M, Post G, Joosten R, Feenstra M, Denys D, Deep brain stimulation in the lateral orbitofrontal cortex impairs spatial reversal learning. BEHAV BRAIN RES 2013;245:7-12 [PubMed]
Klomp A. Antidepressants and the adolescent brain: changing the course of neurodevelopment ?. s.l.: s.n.; 2013. 267p. ISBN 9789088916175 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP; copromotor(s): Reneman L)
Klomp A, van Wingen GA, de Ruiter MB, Caan MWA, Denys D, Reneman L, Test-retest reliability of task-related pharmacological MRI with a single-dose oral citalopram challenge. NEUROIMAGE 2013;75:108-116 [PubMed]
Kroon JS, Wohlfarth TD, Dieleman J, Sutterland AL, Storosum JG, Denys D, de Haan L, Sturkenboom MCJM, Incidence rates and risk factors of bipolar disorder in the general population: a population-based cohort study. BIPOLAR DISORD 2013;15 (3):306-313 [PubMed]
Luigjes J, de Kwaasteniet BP, de Koning PP, Oudijn MS, van den Munckhof P, Schuurman PR, Denys D, Surgery for psychiatric disorders. WORLD NEUROSURG 2013;80 (3-4):S31.e17-S31.e28 [PubMed]
Nijdam MJ, van der Pol MM, Dekens RE, Olff M, Denys D, Treatment of sexual trauma dissolves contamination fear: case report. EUR J PSYCHOTRAUMATO 2013;4:19157 [PubMed]
Oudijn MS, Storosum JG, Nelis E, Denys D, Is deep brain stimulation a treatment option for anorexia nervosa?. BMC PSYCHIATRY 2013;13 (1):277 [PubMed]
Overbeek JM, de Koning PP, Luigjes J, van den Munckhof P, Schuurman PRR, Denys D, Diepe hersenstimulatie bij psychiatrische aandoeningen. NED TIJDSCHR GENEESKD 2013;157 (52):A7015 [PubMed]
Polak AR, Witteveen AB, Mantione M, Figee M, de Koning P, Olff M, van den Munckhof P, Schuurman PR, Denys D, Deep brain stimulation for obsessive-compulsive disorder affects language: a case report. NEUROSURGERY 2013;73 (5):E907-10; discussion E910 [PubMed]
Prosée R, Vulink N, Denys D. Obsessieve-compulsieve stoornis in: Franken I, Muris P, Denys D, editors. Basisboek psychopathologie. Utrecht: De Tijdstroom; 2012., p. 423-442
Rietveld E, de Haan S, Denys D, Social affordances in context: what is it that we are bodily responsive to?. BEHAV BRAIN SCI 2013;36 (4):436 [PubMed]
Schröder A, Vulink N, Denys D, Misophonia: diagnostic criteria for a new psychiatric disorder. PLOS ONE 2013;8 (1):e54706 [PubMed]
Smolders R, Mazaheri A, van Wingen G, Figee M, de Koning PP, Denys D, Deep brain stimulation targeted at the nucleus accumbens decreases the potential for pathologic network communication. BIOL PSYCHIAT 2013;74 (10):e27-e28 [PubMed]
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH Jr, Kennedy JL, Rosenberg D, Stein DJ, Hemmings SMJ, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy DL, Wendland JR, Veenstra-Vanderweele J, Denys D, Blom R, Deforce D, van Nieuwerburgh F, Westenberg HGM, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Conceição do Rosário M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A, Arepalli S, Dillman A, Ferrucci L, Hernandez DG, Johnson R, Longo DL, Nalls MA, O Brien R, Traynor B, Troncoso J, van der Brug M, Zielke HR, Zonderman A, Hardy J, Hardy JA, Ryten M, Smith C, Trabzuni D, Walker R, Weale M, Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL, Genome-wide association study of obsessive-compulsive disorder. MOL PSYCHIATR 2013;18 (7):788-798 [PubMed]
Sutterland AL, Dieleman J, Storosum JG, Voordouw BAC, Kroon J, Veldhuis J, Denys DAJP, de Haan L, Sturkenboom MCJM, Annual incidence rate of schizophrenia and schizophrenia spectrum disorders in a longitudinal population-based cohort study. SOC PSYCH PSYCH EPID 2013;48 (9):1357-1365 [PubMed]
van den Munckhof P, Bosch DA, Mantione MHM, Figee M, Denys DAJP, Schuurman PR, Active stimulation site of nucleus accumbens deep brain stimulation in obsessive-compulsive disorder is localized in the ventral internal capsule. ACTA NEUROCHIR 2013;117 (Suppl.):53-59 [PubMed]
van Dijk A. Understanding deep brain stimulation in obsessive compulsive disorder: a preclinical study into the mechanism of action and behaviour. s.l: s.n.; 2013. 141p. ISBN 9789088916359 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Denys DAJP; copromotor(s): Feenstra MGP)
van Dijk A, Klanker M, van Oorschot N, Post R, Hamelink R, Feenstra MGP, Denys D, Deep brain stimulation affects conditioned and unconditioned anxiety in different brain areas. TRANSL PSYCHIAT 2013;3:e289 [PubMed]
van Dijk MT, van Wingen GA, van Lammeren A, Blom RM, de Kwaasteniet BP, Scholte HS, Denys D, Neural basis of limb ownership in individuals with body integrity identity disorder. PLOS ONE 2013;8 (8):e72212 [PubMed]
Willers LEWG, Vulink NC, Denys D, Stein DJ. The Origin of Anxiety Disorders - An Evolutionary Approach in: Baldwin DS, Leonard BE, editors. Anxiety Disorders. Basel: Karger; 2013. 29, p. 16-23
Blom RM, Figee M, Vulink NCC, Denys D. Electroconvulsive Therapy, Transcranial Magnetic Stimulation and Deep Brain Stimulation in OCD in: Zohar J, editors. Obsessive-Compulsive Disorder: Current Science and Clinical Practice. West Sussex: John Wiley & Sons, Ltd; 2012., p. 75
Blom RM, Hennekam RC, Denys D, Body Integrity Identity Disorder. PLOS ONE 2012;7 (4):e34702 [PubMed]
Carey PD, Lochner C, Kidd M, van Ameringen M, Stein DJ, Denys D, Quetiapine augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: is response to treatment predictable?. INT CLIN PSYCHOPHARM 2012;27 (6):321-325 [PubMed]
Cohen MX, Bour L, Mantione M, Figee M, Vink M, Tijssen MAJ, van Rootselaar AF, van den Munckhof P, Schuurman PR, Denys D, Top-down-directed synchrony from medial frontal cortex to nucleus accumbens during reward anticipation. HUM BRAIN MAPP 2012;33 (1):246-252 [PubMed]
de Koning PP, Munckhof van den P , Figee M, Schuurman PR, Denys D. Deep brain stimulation in obsessive-compulsive disorder targeted at the nucleus accumbens in: Denys D, Feenstra MG, Schuurman PR, editors. Deep Brain Stimulation: A New Frontier in Psychiatry. Berlin; Heidelberg: Springer; 2012., p. 43
Denys D, Feenstra MG, Schuurman PR, editors, Deep Brain Stimulation: A New Frontier in Psychiatry. Berlin; Heidelberg: Springer; 2012. 299p. ISBN 9783642309908
Denys D, Feenstra MG, Schuurman PR. Preface in: Denys D, Feenstra MG, Schuurman PR, editors. Deep Brain Stimulation: A New Frontier in Psychiatry. Berlin; Heidelberg: Springer; 2012., p. vii
Feenstra MG, Denys D. Animal studies in deep brain stimulation research in: Denys D, Feenstra MG, Schuurman PR, editors. Deep Brain Stimulation: A New Frontier in Psychiatry. Berlin; Heidelberg: Springer; 2012., p. 217-224
Figee M, van den Munckhof P, Schuurman PR, Denys D. Neuroimaging deep brain stimulation in psychiatric disorders in: Denys D, Feenstra MG, Schuurman PR, editors. Deep Brain Stimulation: A New Frontier in Psychiatry. Berlin; Heidelberg: Springer; 2012., p. 225-239
Franken I, Muris P, Denys D, editors, Basisboek psychopathologie. Utrecht: De Tijdstroom; 2012. 810p. ISBN 9789058982148
Gobin V, Van Steendam K, Fevery S, Tilleman K, Billiau A, Denys D [Contributors: Deforce D]] , Serotonin reuptake inhibitors as immunomodulators: A proof-of-concept. J NEUROIMMUNOL 2012;253 (1-2):58-58
Klomp A, Caan MWA, Denys D, Nederveen AJ, Reneman L, Feasibility of ASL-based phMRI with a single dose of oral citalopram for repeated assessment of serotonin function. NEUROIMAGE 2012;63 (3):1695-1700 [PubMed]
Klumpers F, Denys D, Kenemans JL, Grillon C, van der Aart J, Baas JMP, Testing the effects of Delta 9-THC and D-cycloserine on extinction of conditioned fear in humans. J PSYCHOPHARMACOL 2012;26 (4):471-478 [PubMed]
Luigjes J, van den Brink W, Feenstra M, van den Munckhof P, Schuurman PR, Schippers R, Mazaheri A, de Vries TJ, Denys D, Deep brain stimulation in addiction: a review of potential brain targets. MOL PSYCHIATR 2012;17 (6):572-583 [PubMed]
Ooms P, van Loon A, Denys D, Psychotherapie en neurobiologie bij obsessieve-compulsieve stoornissen. TIJDSCHR PSYCHIATR 2012;54 (5):449-451 [PubMed]
Polak AR, van der Paardt JW, Figee M, Vulink N, de Koning P, Olff M, Denys D, Compulsive carnival song whistling following cardiac arrest: a case study. BMC PSYCHIATRY 2012;12 (1):75 [PubMed]
Polak AR, Witteveen AB, Visser RS, Opmeer BC, Vulink N, Figee M, Denys D, Olff M, Comparison of the effectiveness of trauma-focused cognitive behavioral therapy and paroxetine treatment in PTSD patients: design of a randomized controlled trial. BMC PSYCHIATRY 2012;12 (1):166 [PubMed]
Prins J. Monoamines and Anhedonia. old targets, new concepts. Utrecht: Universiteit Utrecht; 2012. -p. ISBN 978-90-393-5857-3 Proefschrift Universiteit van Utrecht, Psychiatrie. (Promotor(s): Olivier B, Denys DAJP; copromotor(s): Korte SM, Oosting RS)
Valencia-Alfonso CE, Luigjes J, Smolders R, Cohen MX, Levar N, Mazaheri A, van den Munckhof P, Schuurman PR, van den Brink W, Denys D, Effective Deep Brain Stimulation in Heroin Addiction: A Case Report with Complementary Intracranial Electroencephalogram. BIOL PSYCHIAT 2012;71 (8):E35-E37 [PubMed]
van Dijk A, Klompmakers AA, Feenstra MGP, Denys D, Deep brain stimulation of the accumbens increases dopamine, serotonin, and noradrenaline in the prefrontal cortex. J NEUROCHEM 2012;123 (6):897-903 [PubMed]
van Os J, Kahn R, Denys D, Schoevers RA, Beekman ATF, Hoogendijk WJG, van Hemert AM, Hodiamont PPG, Scheepers F, Delespaul PAEG, Leentjens AFG, ROM: gedragsnorm of dwangmaatregel? Overwegingen bij het themanummer over routine outcome monitoring. TIJDSCHR PSYCHIATR 2012;54 (3):245-253 [PubMed]
van Wingen GA, Geuze E, Caan MWA, Kozicz T, Olabarriaga SD, Denys D, Vermetten E, Fernández G, Persistent and reversible consequences of combat stress on the mesofrontal circuit and cognition. P NATL ACAD SCI USA 2012;109 (38):15508-15513 [PubMed]
Vedam-Mai V, van Battum EY, Kamphuis W, Feenstra MGP, Denys D, Reynolds BA, Okun MS, Hol EM, Deep brain stimulation and the role of astrocytes. MOL PSYCHIATR 2012;17 (2):124-131 [PubMed]
Veldhuis J, Dieleman JP, Wohlfarth T, Storosum JG, van den Brink W, Sturkenboom MCJM, Denys D, Incidence and prevalence of "diagnosed OCD" in a primary care, treatment seeking, population. INT J PSYCHIAT CLIN 2012;16 (2):85-92 [PubMed]
Vulink NCC, Westenberg HGM, van Nieuwerburgh F, Deforce D, Fluitman SBAHA, Meinardi JSC, Denys D, Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder. INT J PSYCHIAT CLIN 2012;16 (4):277-283 [PubMed]
Vulink NC, Figee M, Denys D, Revisión de los antipsicóticos atípicos en la ansiedad. PSIQUIATRIA BIOLÓGICA 2012;19 (Supl. 1):21-41
Zohar J, Greenberg B, Denys D. Obsessive-compulsive disorder in: Schlaepfer T, Nemeroff C, editors. Handbook of Clinical Neurology. Edinburgh: Elsevier; 2012., p. 375
Blom RM, Figee M, Vulink N, Denys D. ECT, TMS, and DBS in OCD in: Maj M, Norman S, Ahmed O, Zohar J, editors. Obsessive compulsive disorder. 2nd ed.. S.l.: Wiley-Blackwell; 2011., p. -
Blom RM, Figee M, Vulink N, Denys D, Update on repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: different targets. CURR PSYCHIAT REP 2011;13 (4):289-294 [PubMed]
Blom RM, Hagestein-de Bruijn C, de Graaf R, ten Have M, Denys DA, Obsessions in normality and psychopathology. DEPRESS ANXIETY 2011;28 (10):870-875 [PubMed]
Blom RM, Koeter M, van den Brink W, de Graaf R, ten Have M, Denys D, Co-occurrence of obsessive-compulsive disorder and substance use disorder in the general population. ADDICTION 2011;106 (12):2178-2185 [PubMed]
de Koning PP, Figee M, van den Munckhof P, Schuurman PR, Denys D, Current status of deep brain stimulation for obsessive-compulsive disorder: a clinical review of different targets. CURR PSYCHIAT REP 2011;13 (4):274-282 [PubMed]
Delucchi KL, Katerberg H, Stewart SE, Denys DAJP, Lochner C, Stack DE, den Boer JA, van Balkom AJLM, Jenike MA, Stein DJ, Cath DC, Mathews CA, Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder. COMPR PSYCHIAT 2011;52 (3):334-341 [PubMed]
Denys D. [Compulsivity] in: Denys D, Meynen G, editors. Handboek Psychiatrie en Filosofie. Utrecht: De Tijdstroom; 2011., p. 241
Denys D, Obsessionality & compulsivity: a phenomenology of obsessive-compulsive disorder. PHILOS ETHICS HUMANIT MED 2011;6:3 [PubMed]
Denys D. [The etiology of body dysmorphic disorder] in: Denys D, Vulink NCC, editors. Body Dysmorphic Disorder. Assen: Koninklijke van Gorcum BV; 2011., p. 51
Denys D, Meynen G, editors, Handboek Psychiatrie en Filosofie. Utrecht: De Tijdstroom; 2011. 315p. ISBN 978 90 5898 193 6
Denys D, Vulink NCC, editors, Body Dysmorphic Disorder. Assen: Koninklijke van Gorcum BV; 2011. 188p. ISBN 978 90 232 4459 2
Figee M, Booij J, Denys D. Molecular imaging of Obsessive compulsive disorder in: Shenton M E., Turetsky B I., editors. Understandig Neuropsychiatric Disorders: Insights from Neuroimaging. S.l.: Cambridge University Press; 2010., p. -
Figee M, Vink M, de Geus F, Vulink N, Veltman DJ, Westenberg H, Denys D, Dysfunctional Reward Circuitry in Obsessive-Compulsive Disorder. BIOL PSYCHIAT 2011;69 (9):867-874 [PubMed]
Fluitman SBAHA. "Everything in its right place" Psychoneuroimmunological studies in OCD, depression and psychosis. Utrecht: Gildeprint Drukkerijen - Enschede; 2011. 149p. ISBN 978-90-3935-545-9 Proefschrift Universiteit van Utrecht, Psychiatrie. (Promotor(s): Westenberg HGM, Denys DAJP; copromotor(s): )
Fluitman SBAHA, Heijnen CJ, Denys DAJP, Nolen WA, Balk FJ, Westenberg HGM, Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorder. J AFFECT DISORDERS 2011;131 (1-3):388-392 [PubMed]
Greenberg B, Zohar J, Denys D. Obsessive-compulsive disorder in: Schlaepfer T, Nemeroff C, editors. Neurobiology of Psychiatric Disease. Edinburgh: Elsevier; 2011., p. -
Luigjes J, Mantione M, van den Brink W, Schuurman PR, van den Munckhof P, Denys D, Deep brain stimulation increases impulsivity in two patients with obsessive-compulsive disorder. INT CLIN PSYCHOPHARM 2011;26 (6):338-340 [PubMed]
Mantione M, Figee M, Denys D. [Deep brain stimulation for treatment refractory obsessive-compulsive disorder] in: van Balkom AJLM, Oosterbaan D, Visser S, van Vliet IM, editors. Handboek Angststoornissen. Utrecht: De Tijdstroom; 2011., p. 431
van Dijk A, Mason O, Klompmakers AA, Feenstra MGP, Denys D, Unilateral deep brain stimulation in the nucleus accumbens core does not affect local monoamine release. J NEUROSCI METH 2011;202 (2):113-118 [PubMed]
Vulink NCC, Figee M, Denys D, Review of atypical antipsychotics in anxiety. EUR NEUROPSYCHOPHARM 2011;21 (6):429-449 [PubMed]
de Bruijn C, Beun S, de Graaf R, ten Have M, Denys D, Subthreshold symptoms and obsessive-compulsive disorder: evaluating the diagnostic threshold. PSYCHOL MED 2010;40 (6):989-997 [PubMed]
Denys D, Moraliteit is wars van empathie. NVBE NIEUWSBRIEF 2010;17 (1):6-8
Denys D, Mantione M, Figee M, van den Munckhof P, Koerselman F, Westenberg H, Bosch A, Schuurman R, Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder. ARCH GEN PSYCHIAT 2010;67 (10):1061-1068 [PubMed]
Figee M, Mantione M, van den Munckhof P, Schuurman R, Denys D, Targets for Deep Brain Stimulation in Obsessive-Compulsive Disorder. PSYCHIAT ANN 2010;40 (10):492-498
Fluitman SBAHA, Denys DAJP, Heijnen CJ, Westenberg HGM, Disgust affects TNF-alpha, IL-6 and noradrenalin levels in patients with obsessive-compulsive disorder. PSYCHONEUROENDOCRINO 2010;35 (6):906-911 [PubMed]
Fluitman S, Denys D, Vulink N, Schutters S, Heijnen C, Westenberg H, Lipopolysaccharide-induced cytokine production in obsessive-compulsive disorder and generalized social anxiety disorder. PSYCHIAT RES 2010;178 (2):313-316 [PubMed]
Kas MJH, Gelegen C, van Nieuwerburgh F, Westenberg HGM, Deforce D, Denys D, Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive-compulsive disorder. AM J MED GENET B 2010;153 (1):252-259 [PubMed]
Katerberg H, Cath DC, Denys DAJP, Heutink P, Polman A, van Nieuwerburgh FCW, Deforce DLD, Bochdanovits Z, van Balkom AJLM, den Boer JA, The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive-Compulsive Disorder. AM J MED GENET B 2010;153 (1):167-176 [PubMed]
Katerberg H, Delucchi KL, Stewart SE, Lochner C, Denys DAJP, Stack DE, Andresen JM, Grant JE, Kim SW, Williams KA, den Boer JA, van Balkom AJLM, Smit JH, van Oppen P, Polman A, Jenike MA, Stein DJ, Mathews CA, Cath DC, Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates. BEHAV GENET 2010;40 (4):505-517 [PubMed]
Leckman JF, Denys D, Simpson HB, Mataix-Cols D, Hollander E, Saxena S, Miguel EC, Rauch SL, Goodman WK, Phillips KA, Stein DJ, Obsessive-compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM-V. DEPRESS ANXIETY 2010;27 (6):507-527 [PubMed]
Mantione M, van de Brink W, Schuurman PR, Denys D, Smoking Cessation and Weight Loss After Chronic Deep Brain Stimulation of the Nucleus Accumbens: Therapeutic and Research Implications: Case Report. NEUROSURGERY 2010;66 (1):218 [PubMed]
Olff M, Langeland W, Witteveen A, Denys D, A Psychobiological Rationale for Oxytocin in the Treatment of Posttraumatic Stress Disorder. CNS SPECTRUMS 2010;15 (8):522-530 [PubMed]
Prins J, Denys DA, Westphal KG, Korte-Bouws GA, Quinton MS, Schreiber R, Groenink L, Olivier B, Korte SM, The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. EUR J PHARMACOL 2010;633 (1-3):55-61 [PubMed]
Schutters SIJ, van Megen HJGM, van Veen JF, Denys DAJP, Westenberg HGM, Mirtazapine in generalized social anxiety disorder: a randomized, double-blind, placebo-controlled study. INT CLIN PSYCHOPHARM 2010;25 (5):302-304 [PubMed]
Stein DJ, Fineberg NA, Bienvenu OJ, Denys D, Lochner C, Nestadt G, Leckman JF, Rauch SL, Phillips KA, Should OCD be classified as an anxiety disorder in DSM-V?. DEPRESS ANXIETY 2010;27 (6):495-506 [PubMed]
de Haan L, Dudek-Hodge C, Verhoeven Y, Denys D, Prevalence of psychotic disorders in patients with obsessive-compulsive disorder. CNS SPECTRUMS 2009;14 (8):415-417 [PubMed]
Denys D. Wat is Psychiatrie? (DVD Inaugurele rede, Universiteit van Amsterdam). Amsterdam: Vossius Pers, UvA; 2009. 9p. ISBN 9789056295806, e-ISBN 9789048510863
Denys D, Mantione M, Deep brain stimulation in obsessive-compulsive disorder. PROG BRAIN RES 2009;175:419-427 [PubMed]
Figee M, Denys D, New pharmacotherapeutic approaches to obsessive-compulsive disorder. CNS SPECTRUMS 2009;14 (2 Suppl 3):13-23 [PubMed]
Nieman DH, Rike WH, Becker HE, Dingemans PM, van Amelsvoort TA, de Haan L, van der Gaag M, Denys DAJP, Linszen DH, Prescription of antipsychotic medication to patients at ultra high risk of developing psychosis. INT CLIN PSYCHOPHARM 2009;24 (4):223-228 [PubMed]
Spitzer U, Figee M, Mantione M, Denys D, To feel free or to be free? To the psychology of experience of patients with obsessive compulsive disorders under deep brain stimulation. NERVENHEILKUNDE 2009;28 (9):634-642
Stein DJ, Denys D, Deep brain stimulation in obsessive-compulsive disorder. CURR PSYCHIAT REP 2009;11 (4):259-260 [PubMed]
Stein DJ, Denys D, Recent advances in understanding and treating the anxiety disorders. Introduction. CNS SPECTRUMS 2009;14 (2 Suppl 3):4 [PubMed]
Stein DJ, Denys D, Gloster AT, Hollander E, Leckman JF, Rauch SL, Phillips KA, Obsessive-compulsive disorder: diagnostic and treatment issues. PSYCHIAT CLIN N AM 2009;32 (3):665-685 [PubMed]
van Dijk A, Klompmakers AA, Denys D. The serotonergic system in obsessive compulsive disorders in: Muller C, Jacobs B, editors. Handbook of the Behavioral Neurobiology of Serotonin, 21. S.l.: ACADEMIC PRESS; 2009. 21, p. -
van Megen H, Denys D. Obsessieve-compulsieve stoornis in: Hengeveld MW, van Balkom AJLM, editors. Leerboek psychiatrie (2e dr.). Utrecht: De Tijdstroom; 2009., p. 343-352
van Nieuwerburgh FCW, Denys DAJP, Westenberg HGM, Deforce DLD, Response to serotonin reuptake inhibitors in OCD is not influenced by common CYP2D6 polymorphisms. INT J PSYCHIAT CLIN 2009;13 (4):345-348 [PubMed]
Vulink NCC. Feelings of incompleteness - Studies on dopamine in obsessive-compulsive disorder. Utrecht: Gildeprint Drukkerijen; 2009. 147p. ISBN 987-90-393-5175-8 Proefschrift Universiteit van Utrecht, -. (Promotor(s): Westenberg HGM, Denys DAJP; copromotor(s): )
Vulink NCC, Denys D, Fluitman SBAHA, Meinardi JCM, Westenberg HGM, Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients. J CLIN PSYCHIAT 2009;70 (7):1001-1008 [PubMed]
Denys D, Diepe hersenstimulatie bij psychiatrische stoornissen. NED TIJDSCHR GENEESKD 2008;152 (43):2330-2335 [PubMed]
Denys D, de Haan L, 25 jaar antipsychotica: back to the future?. TIJDSCHR PSYCHIATR 2008;50 (13):105-109 [PubMed]
Denys D, Fineberg N, Carey PC, Stein DJ, Reply. BIOL PSYCHIAT 2008;63 (1):e7
Mantione M, Denys D, [Deep Brain Stimulation & CBT: a winning team?]. TIJDSCHR PSYCHIATR 2008;12:133-136
Montagne B, de Geus F, Kessels RPC, Denys D, de Haan EHF, Westenberg HGM, Perception of facial expressions in obsessive-compulsive disorder: a dimensional approach. EUR PSYCHIAT 2008;23 (1):26-28 [PubMed]
van Dijk A, Klompmakers AA, Denys D, Role of serotonin in obsessive-compulsive disorder. FUTURE NEUROL 2008;3 (5):589-603
Vulink NCC, Rosenberg A, Plooij JM, Koole R, Bergé SJ, Denys D, Body dysmorphic disorder screening in maxillofacial outpatients presenting for orthognathic surgery. INT J ORAL MAX SURG 2008;37 (11):985-991 [PubMed]
de Bruijn C, Denys D, Predicting pharmacotherapy outcome from a retrospective chart study?. J CLIN PSYCHIAT 2007;68 (1):167; author reply 167-167; author reply 168 [PubMed]
de Geus F, Denys DAJP, Sitskoorn MM, Westenberg HGM, Attention and cognition in patients with obsessive-compulsive disorder. PSYCHIAT CLIN NEUROS 2007;61 (1):45-53 [PubMed]
de Geus F, Denys D, Westenberg HGM, Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder. INT CLIN PSYCHOPHARM 2007;22 (2):77-84 [PubMed]
Denys D. De etiopathogenese van de obsessieve-compulsieve stoornis in: Denys D, de Geus F, editors. Handboek obsessieve-compulsieve stoornissen. Utrecht: De Tijdstroom; 2007., p. 49
Denys D. Fenomenologie van de obessieve-compulsieve stoornis [Hfdstk.2] in: Denys D, de Geus F, editors. Handboek obsessieve-compulsieve stoornissen. Utrecht: De Tijdstroom; 2007., p. 23-34
Denys D. Het concept obsessieve-compulsieve spectrum stoornissen in: Denys D, de Geus F, editors. Handboek obsessieve-compulsieve stoornissen. Utrecht: De Tijdstroom; 2007., p. 185
Denys D, How new is the new philosophy of psychiatry?. PHILOS ETHICS HUMANIT MED 2007;2:22 [PubMed]
Denys D, Cath DC. Genetica van de obsessieve-compulsieve stoornis in: Denys D, de Geus F, editors. Handboek obsessieve-compulsieve stoornissen. Utrecht: De Tijdstroom; 2007., p. 85
Denys D, de Geus F, editors, Handboek obsessieve-compulsieve stoornissen. Utrecht: De Tijdstroom; 2007. 391p. ISBN 9789058980878
Denys D, Fineberg N, Carey PD, Stein DJ, Quetiapine addition in obsessive-compulsive disorder: is treatment outcome affected by type and dose of serotonin reuptake inhibitors?. BIOL PSYCHIAT 2007;61 (3):412-414 [PubMed]
Denys D, van Nieuwerburgh F, Deforce D, Westenberg HGM, Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial. J CLIN PSYCHIAT 2007;68 (5):747-753 [PubMed]
van der Wee NJA, Ramsey NF, van Megen HJGM, Denys D, Westenberg HGM, Kahn RS, Spatial working memory in obsessive-compulsive disorder improves with clinical response: A functional MRI study. EUR NEUROPSYCHOPHARM 2007;17 (1):16-23 [PubMed]
Westenberg HGM, Fineberg NA, Denys D, Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS SPECTRUMS 2007;12 (2 Suppl 3):14-27 [PubMed]
de Bruijn C, Denys D, Post-traumatic stress disorder after life events. BRIT J PSYCHIAT 2006;188:394-5; author reply 395 [PubMed]
Denys D. Obsessieve compulsieve disorders in: Pepplinkhuizen L, editor. Het psychiatrisch formularium. S.l.: Bohn Stafleu Van Loghum; 2006., p. -
Denys D. [Obsessive compulsive disorder: A terrible Uncertainty] in: Hovens JE, van der Ploeg GJ, editors. De grote psychiatrie in klassieke teksten. Utrecht: De Tijdstroom; 2006., p. 571-572
Denys D, Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders. PSYCHIAT CLIN N AM 2006;29 (2):553-84, xi [PubMed]
Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg HGM, Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder. PSYCHONEUROENDOCRINO 2006;31 (3):355-360 [PubMed]
Denys D, van Nieuwerburgh F, Deforce D, Westenberg H, Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males. EUR NEUROPSYCHOPHARM 2006;16 (6):446-450 [PubMed]
Denys D, van Nieuwerburgh F, Deforce D, Westenberg HGM, Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder. J AFFECT DISORDERS 2006;91 (1):39-44 [PubMed]
Fineberg NA, Stein DJ, Premkumar P, Carey P, Sivakumaran T, Vythilingum B, Seedat S, Westenberg H, Denys D, Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: a meta-analysis of randomized controlled treatment trials. INT CLIN PSYCHOPHARM 2006;21 (6):337-343 [PubMed]
Stein DJ, Bolton D, Denys D, Huddle T, Powell T, Philosophy, Ethics, and Humanities in Medicine: expanding the open-access conversation on health care. PHILOS ETHICS HUMANIT MED 2006;1 (1):E1 [PubMed]
van der Wee NJ, Hardeman HH, Ramsey NF, Raemaekers M, van Megen HJ, Denys DA, Westenberg HG, Kahn RS, Saccadic abnormalities in psychotropic-naive obsessive-compulsive disorder without co-morbidity. PSYCHOL MED 2006;36 (9):1321-1326 [PubMed]
van Nieuwerburgh F. The genetics of obsessive-compulsive disorder. Gent: s.n.; 2006. -p. Proefschrift UZ Gent, -. (Promotor(s): Denys DAJP; copromotor(s): )
Vulink NCC, Denys D, Bus L, Westenberg HGM, Female hormones affect symptom severity in obsessive-compulsive disorder. INT CLIN PSYCHOPHARM 2006;21 (3):171-175 [PubMed]
Vulink NCC, Denys D, Bus L, Westenberg HGM, Sexual pleasure in women with obsessive-compulsive disorder?. J AFFECT DISORDERS 2006;91 (1):19-25 [PubMed]
Vulink NCC, Sigurdsson V, Kon M, Bruijnzeel-Koomen CAFM, Westenberg HGM, Denys D, Stoornis in de lichaamsbeleving bij 3-8% van de patiënten op de poliklinieken Dermatologie en Plastische Chirurgie. NED TIJDSCHR GENEESKD 2006;150 (2):97-100 [PubMed]
Denys D, de Geus F, Predictors of pharmacotherapy response in anxiety disorders. CURR PSYCHIAT REP 2005;7 (4):252-257 [PubMed]
Tenneij NH, van Megen HJGM, Denys DAJP, Westenberg HGM, Behavior therapy augments response of patients with obsessive-compulsive disorder responding to drug treatment. J CLIN PSYCHIAT 2005;66 (9):1169-1175 [PubMed]
Vulink NCC, Denys D, [Body dysmorphic disorder: A review] Russian. SOTSYAL'NAYA I KLINICHESKAYA PSIKHYATRIYA 2005;14 (4):98-102
Vulink NCC, Denys D, Westenberg HGM, Bupropion for patients with obsessive-compulsive disorder: an open-label, fixed-dose study. J CLIN PSYCHIAT 2005;66 (2):228-230 [PubMed]
Vulink N, Denys D, [Body Dysmorphic disorder: A review]. TIJDSCHR PSYCHIATR 2005;47:21-27
Vulink N, Denys D. [Could you modify my nose?] in: van Balkom AJLM, Hengeveld MW, editors. Probleemgeoriënteerd denken in de psychiatrie. Utrecht: De Tijdstroom; 2005., p. -
de Geus F, Denys D, Pitfalls in factor analytic techniques. AM J PSYCHIAT 2004;161 (3):579-580 [PubMed]
Denys D. On certainty: Studies in obsessive-compulsive disorder (PhD thesis). Ridderkerk: Ridderprint offsetdrukkerij b.v.; 2004. -p. ISBN 9039336385
Denys D, de Geus F, van Megen HJGM, Westenberg HGM, A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors. J CLIN PSYCHIAT 2004;65 (8):1040-1048 [PubMed]
Denys D, de Geus F, van Megen HJGM, Westenberg HGM, Symptom dimensions in obsessive-compulsive disorder: factor analysis on a clinician-rated scale and a self-report measure. PSYCHOPATHOLOGY 2004;37 (4):181-189 [PubMed]
Denys D, de Geus F, van Megen HJGM, Westenberg HGM, Use of factor analysis to detect potential phenotypes in obsessive-compulsive disorder. PSYCHIAT RES 2004;128 (3):273-280 [PubMed]
Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg H, Decreased TNF-alpha and NK activity in obsessive-compulsive disorder. PSYCHONEUROENDOCRINO 2004;29 (7):945-952 [PubMed]
Denys D, Klompmakers AA, Westenberg HGM, Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine. PSYCHOPHARMACOLOGY 2004;176 (2):195-203 [PubMed]
Denys D, Tenney N, van Megen HJGM, de Geus F, Westenberg HGM, Axis I and II comorbidity in a large sample of patients with obsessive-compulsive disorder. J AFFECT DISORDERS 2004;80 (2-3):155-162 [PubMed]
Denys D, van der Wee N, Janssen J, de Geus F, Westenberg HGM, Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. BIOL PSYCHIAT 2004;55 (10):1041-1045 [PubMed]
Denys D, van Megen HJGM, van der Wee N, Westenberg HGM, A double-blind switch study of paroxetine and venlafaxine in obsessive-compulsive disorder. J CLIN PSYCHIAT 2004;65 (1):37-43 [PubMed]
Denys D, Zohar J, Westenberg HGM, The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. J CLIN PSYCHIAT 2004;65 (Suppl. 14):11-17 [PubMed]
Fluitman S, Denys D, PANDAS: A review. TIJDSCHR PSYCHIATR 2004;46:755-761
van der Wee NJ, Stevens H, Hardeman JA, Mandl RC, Denys DA, van Megen HJ, Kahn RS, Westenberg HM, Enhanced dopamine transporter density in psychotropic-naive patients with obsessive-compulsive disorder shown by [123I]{beta}-CIT SPECT. AM J PSYCHIAT 2004;161 (12):2201-2206 [PubMed]
Denys D, Reply to Clozapine and fluvoxamine together: More than two times alone. TIJDSCHR PSYCHIATR 2003;45:409-411
Denys DA, Cath DC, De erfelijkheid van obsessieve-compulsieve stoornissen. NED TIJDSCHR GENEESKD 2003;147 (44):2166-2169 [PubMed]
Denys D, Burger H, van Megen H, de Geus F, Westenberg H, A score for predicting response to pharmacotherapy in obsessive-compulsive disorder. INT CLIN PSYCHOPHARM 2003;18 (6):315-322 [PubMed]
Denys D, van der Wee N, van Megen HJGM, Westenberg HGM, A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder. J CLIN PSYCHOPHARM 2003;23 (6):568-575 [PubMed]
Denys D, van Megen HJGM, Westenberg HGM, Emerging skin-picking behaviour after serotonin reuptake inhibitor-treatment in patients with obsessive-compulsive disorder: possible mechanisms and implications for clinical care. J PSYCHOPHARMACOL 2003;17 (1):127-129 [PubMed]
Tenney NH, Denys DAJP, van Megen HJGM, Glas G, Westenberg HGM, Effect of a pharmacological intervention on quality of life in patients with obsessive-compulsive disorder. INT CLIN PSYCHOPHARM 2003;18 (1):29-33 [PubMed]
Tenney NH, Schotte CKW, Denys DAJP, van Megen HJGM, Westenberg HGM, Assessment of DSM-IV personality disorders in obsessive-compulsive disorder: comparison of clinical diagnosis, self-report questionnaire, and semi-structured interview. J PERS DISORD 2003;17 (6):550-561 [PubMed]
van der Wee NJA, Ramsey NF, Jansma JM, Denys DA, van Megen HJGM, Westenberg HMG, Kahn RS, Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex. NEUROIMAGE 2003;20 (4):2271-2280 [PubMed]
Denys D, de Haan L, Reply to Neurotic Excoriations and OCD. TIJDSCHR PSYCHIATR 2002;44:409-411
Denys D, Kavelaars A, Heijnen CJ, Westenberg H, A case of venlafaxine-induced inhibition of T-lymphocyte proliferation. PSYCHOPHARMACOLOGY 2002;164 (4):432 [PubMed]
Denys D, van Megen H, Westenberg H, Quetiapine addition to serotonin reuptake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: an open-label study. J CLIN PSYCHIAT 2002;63 (8):700-703 [PubMed]
Denys D, van Megen H, Westenberg H, The adequacy of pharmacotherapy in outpatients with obsessive-compulsive disorder. INT CLIN PSYCHOPHARM 2002;17 (3):109-114 [PubMed]
Denys D, van Megen HJ, Westenberg HG, Tekortschietende farmacotherapie bij patiënten met dwangstoornissen. NED TIJDSCHR GENEESKD 2001;145 (19):914-918 [PubMed]
Key publications

Bergfeld IO, Mantione M, Hoogendoorn MLC, Ruhé HG , Notten P, van Laarhoven J, Visser I , Figee M, de Kwaasteniet BP, Horst F, Schene AH, van den Munckhof P, Beute G, Schuurman R, Denys D, Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Treatment-Resistant Depression: A Randomized Clinical Trial. JAMA PSYCHIAT 2016;73 (5):456-464 [PubMed]
Aleman A, Denys D, A road map for suicide research and prevention. NATURE 2014;509 (7501):421-423 [PubMed]
Denys D, Mantione M, Figee M, van den Munckhof P, Koerselman F, Westenberg H, Bosch A, Schuurman R, Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder. ARCH GEN PSYCHIAT 2010;67 (10):1061-1068 [PubMed]
Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, Mantione M, Ooms P, de Koning P, Vulink N, Levar N, Droge L, van den Munckhof P, Schuurman PR, Nederveen A, van den Brink W, Mazaheri A, Vink M, Denys D, Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. NAT NEUROSCI 2013;16 (4):386-387 [PubMed]
Figee M, Vink M, de Geus F, Vulink N, Veltman DJ, Westenberg H, Denys D, Dysfunctional Reward Circuitry in Obsessive-Compulsive Disorder. BIOL PSYCHIAT 2011;69 (9):867-874 [PubMed]


All Publications

Curriculum Vitae

Curriculum Vitae

Personalia

 

                           Titles, initials, name:                    Prof. Dr. D.A.J.P. (Damiaan) Denys

Date and place of birth:               9 November 1965, Wevelgem, Belgium

Nationality:                                     Belgian
Married to:                                      Katrien van Wijnendaele

Children:                                          Elias, Sebastiaan, Jasper

Address:                                           Academic Medical Center (AMC) of the

      University of Amsterdam

      Department of Psychiatry (room PA.2-179)

      Meibergdreef 5, 1105 AZ Amsterdam

Postal address:                               PO Box 22660, 1100 DD Amsterdam  

Phone:                                               +31-20-8913899

Email:                                               
d.denys@amc.nl

Websites:                                         amc.nl/damiaandenys

                                                                                        damiaandenys.com                     

                                                                                        herseninstituut.nl/en

 

Research focus

 

Damiaan Denys conducts psychiatric research into anxiety, impulsive and compulsive disorders. His scientific research is characterized by a translational approach and makes use of clinical psychiatry, philosophy and neuroscience. A particular focus of his research is the development of deep brain stimulation (DBS) for psychiatric disorders such as obsessive-compulsive disorder, depression, addiction and eating disorders.

 

Academic Achievements

 

2007 - current             Professor of Psychiatry (Kernhooglereaar)
University of Amsterdam (UvA), Amsterdam, Netherlands

 

2009 – current            Team leader of research group ‘Neuromodulation and Behaviour’
Netherlands Institute for Neuroscience (NIN),
an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands

 

2004 - 2007                  Assistant Professor of Psychiatry
University Medical Centre (UMC) Utrecht, Netherlands

 

2000 - 2004                 PhD in Psychiatry – cum laude

                                        University Medical Centre (UMC) Utrecht, Netherlands

Thesis title: “On certainty: studies in obsessive compulsive disorder”

 

1989 – 1996                 Master (MD) in Medicine

University of Leuven (KUL), Belgium

 

1984 -1989                  Master (MSc) in Philosophy

                                         University of Leuven (KUL), Belgium

Thesis title: “The personality concept in “Le Cas Aimee” from the earlier works of Jacques Lacan”

Medical Experience

 

2007 - current             Chair of the Department of Psychiatry

Academic Medical Center (AMC), Amsterdam, Netherlands

 

2004 – 2007                Chief section Anxiety Disorders

University Medical Centre (UMC) Utrecht, Netherlands

                                                                                                                                                                                                     

2002 - 2004                 Staff member section Anxiety Disorders
University Medical Centre (UMC) Utrecht, Netherlands

 

1996 - 2002                  Residency in Psychiatry & registration as Psychiatrist

University of Leuven (KUL), Belgium & University Medical Centre (UMC) Utrecht, Netherlands

 

Administrative Experience         

 

2016 – current                 President of the Dutch Psychiatric Association (Nederlandse Vereniging voor PsychiatrieNVvP)

2016 – current                 Member of the executive committee of the European College of Neuropsychopharmacology (ECNP)

2012 - current                  Chair of the Senate of the University of Amsterdam

2011 - current                  Chair of the division of Mind, Brain and Senses at the AMC Amsterdam, Netherlands

2010 – current                 Supervisory Board of Ipse de Bruggen - an institution for people with mental disabilities

2009 – current                 Member of the scientific board of the Netherlands Brain Bank (NHB)

2008 – 2010                      Advisor of the America Psychiatric Association (APA) DSM-V committee

 

Editorial Experience

 

2014 - current              Editorial board member (Review editor) of Neuropsychiatric Imaging and Stimulation (specialty section of Frontiers in Psychiatry)

2011 - current              Editorial board member of the Journal of Obsessive-Compulsive and Related Disorders

2010 - current              Editorial board member of the Journal of Behavioral Addictions

2007 - current              Editorial board member of Reviews on Clinical trials

2006 - current              Associate Editor of Philosophy, Ethics and Humanities in Medicine

 

Memberships

 

2010 - current                                 International College of Obsessive Compulsive Spectrum Disorders (ICOCS)

2006 - current                                 International College of Neuropsychopharmacology (CINP)

2006 – current                                Dutch Association for Psychiatry (NVvP)

2006 - current                                 International OCD genetics consortium

2006 – current                                European College of Neuropsychopharmacology (ECNP)

2006 - current                                 Society for Neuroscience (SFN)

 

Grants & Scholarships

Total grant amount in euros: ca. 14.000K (consortium); allocated to own group/lab: ca. 4.000K

 

2017     UvA, ABC project grant (collaboration with Jan Engelmann, FEB & Anneke Goudriaan, AMC)

2016     ZonMW suicide grant

2015     AMC Innovation Impulse

2015     AMC Innovation Impulse

2013     Hersenstichting Nederland, Kleine subsidies

2012     NWO, Investeringen NWO-groot (collaboration with Inge Huitinga, NBB)

2012     NWO, ZonMw, Fonds Neuropsychoanalyse

2012     Medtronic, 10 devices for treatment trial

2012     Hersenstichting Nederland, Kleine subsidies

2011     NWO, ZonMw, Doelmatigheid, VEMI

2010     NWO, FES Program, Hersenen & Cognitie

2009     UvA, CSCA Program (Collaboration with Richard Ridderinkhof, UvA)

2009     NWO, ZonMw, Risk Behaviour and Dependency (collaboration with Wim van den Brink, AMC)

2008     NWO, ZonMw, Doelmatigheid, VEMI (collaboration with Danielle Cath, UU)

2007     Medtronic, 26 devices for treatment trial (collaboration with Rick Schuurman, AMC)

2006     NWO,   Clinical fellow-program

2006     NWO, Open MAGW program (collaboration with Marcel van den Hout, UU)

2005     US Tourette Syndrome Association (collaboration with Danielle Cath, UU)

2005     NWO, VENI program

2005     Medtronic, 16 devices for treatment trial (collaboration with Rick Schuurman, AMC)

 

Awards & Honors

2005:    Ramaer Medaille”, scholarly award from the Dutch Society of Psychiatry for outstanding clinical research in psychiatry.

2005:    “De Girard de Mielet van Coehoorn” medaille for Cum Laude PhD thesis, scientific award from the UMC Utrecht.

 

Patent

Allogeneic immune response control

Dieter DEFORCE, Damiaan DENYS, Veerle GOBIN, Kelly TILLEMAN

WO Patent 2,013,076,245, 2013

 

Public Lectures

Damiaan Denys regularly gives public lectures at the interface of philosophy, psychiatry and neurosciences on topics including fear, control, freedom, deep brain stimulation, happiness and psychiatry. He was a speaker at Wetenschapscafe (de Rode Hoed), Studium Generale, de Nacht van de filosofie, Writers Unlimited, and the Paradisolezing, among others. Damiaan has been a guest in various radio and television programs including Pauw & Witteman and De Wereld Draait Door (DWDD) and gave a lecture at the Universiteit van Nederland. In August 2015, Damiaan Denys was a guest in the Dutch television program Zomergasten (VPRO) and in 2016 in Kijken in de Ziel.

 

Theatre

Since 2013 Denys brings science into  theater. He wrote a monologue on anxiety and freedom, and performs on stage in theatres throughout the Netherlands and Belgium.

 

Columns & Essays

Damiaan Denys regularly writes columns and essays. He is columnist for “De Psychiater” and writes fortnightly columns for the science section of newspaper “Het Parool”.

 

Publications

Total publications:                        n =  258
Books:                                               n =  8
Book chapters:                          n =  37

 

Top-publications:

  • Bergfeld, I, Schuurman R., and Denys, D (2016)Deep Brain Stimulation of the ventral Anterior Limb of the Internal Capsule for Treatment-Resistant Depression: A randomized clinical trial’ JAMA Psychiatry [IF = 12.008]

  • Aleman, A., Denys, D. (2014). Mental health: A road map for suicide research and prevention. Nature. 509(7501):421-3. [IF = 42.351]

  • Figee M., Luigjes J., Smolders R., Valencia-Alfonso C., van Wingen G., de Kwaasteniet B., Mantione M., Ooms P., de Koning P., Vulink N., Levar N., Droge L., van den Munckhof P., Schuurman P.R., Nederveen A., van den Brink W., Mazaheri A., Vink M. and Denys D. (2013). Regaining control: deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nature Neuroscience 16(4): 386-7. [IF 16.095]

  • Luigjes, J., van den Brink, W., Feenstra, M., van den Munckhof, P., Schuurman, P.R., Schippers, R., Mazaheri, A., De Vries, T. J., & Denys, D. (2012). Deep brain stimulation in addiction: a review of potential brain targets. Molecular Psychiatry,17(6):572-83 [IF 14.897]

  • Denys, D., Mantione, M., Figee, M., van den Munckhof, P., Koerselman, F., Westenberg, H., Bosch A., Schuurman R. (2010). Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Archives of General Psychiatry, 67(10), 1061-8. [IF 10.782]

     

    Books

  • Franken, I., Muris P., Denys D. (Eds.) (2015 tweede druk). Psychopathologie. Oorzaken, diagnostiek en behandeling. De Tijdstroom uitgeverij BV, Utrecht. ISBN 9789058982773.

  • Ingmar Franken, Peter Muris, Damiaan Denys (Eds.), (2013 eerste druk). Basisboek Psychopathologie. De Tijdstroom uitgeverij BV, Utrecht. ISBN 9789058982148.

  • Damiaan Denys, Matthijs Feenstra, Rick Schuurman (Eds.), (2012). Deep Brain Stimulation: A New Frontier in Psychiatry. Springer-Verlag GmbH Berlin/Heidelberg. ISBN 9783642309908.

  • Damiaan Denys, Nienke Vulink (Eds.), (2011). Body Dysmorphic Disorder. Koninklijke van Gorcum BV, Assen. ISBN 9789023244592.

  • Damiaan Denys, Gerben Meynen (Eds.), (2011). Handboek Psychiatrie en Filosofie. De Tijdstroom uitgeverij BV, Utrecht. ISBN 9789058981936.

  • Denys, D. (2009). Wat is Psychiatrie? (Inaugurele rede, Universiteit van Amsterdam), Vossius Pers, ISBN 9789056295806 e-ISBN 9789048510863.

  • Damiaan Denys, Femke de Geus (Eds.), (2007). Handboek Obsessieve-compulsieve stoornissen, eerste druk. De Tijdstroom uitgeverij BV, Utrecht. ISBN 9789058980878.

  • Damiaan Denys, (2004). On certainty: studies in obsessive compulsive disorder. PhD thesis. Ridderprint offsetdrukkerij b.v., Ridderkerk, ISBN 9039336385.

     

PhD supervision

Completed PhD students:          n = 17

Current PhD students:                n = 36

 

Research programmes

Deep Brain Stimulation and Obsessive-Compulsive Disorders

Deep brain stimulation or DBS has shown to be effective in therapy-resistant cases of a number of neurological and psychiatric diseases. However, it has not yet been fully determined which psychiatric symptoms respond best to DBS and which brain targets are optimal. Additionally, despite extensive clinical and experimental research, our knowledge of the mechanisms of action of DBS still is limited.
The research program of this group focuses on two main questions. 1. How can DBS be used safely and efficaciously for the treatment of compulsivity, depression, addiction and eating disorders? 2. How does successful DBS alter neurotransmission in these diseases? As these diseases are characterized by profound behavioral alterations due to disturbances of affect, motivation and cognition, our research is focused on neurobiological substrates of motivational behavior in general.
Our approach is translational and multidisciplinary; clinical findings from DBS studies in humans are translated in relevant animal models, in which we observe effects of DBS on behavior and its underpinning neurocircuitry. Our human research tools include methods for intracerebral electrophysiological recordings, functional MRI, SPECT, neuroendocrinology and genetics in combination with neuropsychological tests.
Research Topics

• Deep Brain Stimulation in chronic treatment-refractory drug dependence: A pilot study
• EEG and intracranial recording of local field potential in the human Nucleus Accumbens
• Effects of Chronic Fluoxetine use on the developing brain
• Effects of DBS in Nucleus Accumbens in OCD on brain activity and dopamine release
• Effects of DBS in Nucleus Accumbens subareas on neuronal responses in the cortico-striato-thalamo-cortical circuits
• Cognitive and behavioural aspects of deep brain stimulation in obsessive-compulsive disorder
• The effect of neurostimulation in rodents in relation to obsessive compulsive disorder
• Effects of neuromodulation in the cortico-striatal-thalamo-cortical circuits on striatal dopamine release and motivated behaviour 
• Geographic variation in efficacy and generalizability of pharmacological treatment in schizophrenia, bipolar disorder and OCD
• Neuroimaging of Deep Brain Stimulation in treatment-refractory patients with major depressive disorder 
• Neuropsychological effects of deep brain stimulation of the nucleus accumbens on treatment-refractory patients with major depressive disorder
• Quality of life and cost effectiveness of deep brain stimulation in psychiatric disorders
• Body Dysmorphic Disorder (BDD): Studies in imagined ugliness 
• Deep Brain Stimulation in patients with refractory OCD and refractory major depression: possible immunological and HPA axis changes
• Deep Brain Stimulation in Treatment-refractory patients with Anorexia Nervosa: a Pilot Study
• Feelings of Incompleteness – studies on dopamine in obsessive-compulsive disorder
• Database research and genetics
• The concept of obsessionality: similarities in the obsessive compulsive spectrum
• Body Identity Integrity Disorder (BIID)
• Inhibitory control over emotions: GABAergic regulation of the amygdala
• ADHD: a disconnection between the attentional control and sensory systems of the brain?
• The impact of DBS on the phenomenology of psychiatric patients
• Global neural networks involved in Deep Brain Stimulation and reward-driven behaviour
• Stress, habits and attachment in OCD
• Structural and functional connectivity in attention and motor control
• Misophonia: an imaging study on the neurobiology and the efficacy of cognitive behavioural therapy
• Methodological aspects of genetic analyses
• Effects of deep brain stimulation and developmental drug treatment on functional connectivity in rat brain circuits
• Virtual reality GAME for OCD patients
• TRACE - TRacing genetics of Alcoholism and Comorbid disorders in Extended pedigrees

Faculty
Prof. dr. D.A.J.P. Denys
Dr. M. Figee MD PhD
Prof. dr. P.R. Roelfsema PhD (NIN)
Prof. dr. R. Turner PhD (Spinoza)
Dr. N.C.C. Vulink MD PhD

Postdocs
M.G. Feenstra PhD (NIN)
P.C. Klink PhD (NIN)
D.W. Rietveld PhD
I. Willuhn PhD (NIN)
Dr. G.A. van Wingen PhD

PhD Students
M.N. Bais
K. Bangel
M.J. van Bennekom
I. Bergfeld MSc
B.J.G. van den Boom (NIH)
W.B. Bruin
K.C. Cerrone
M. Derksen (NIN)
R.M. van Diepen
Drs. A.C. Domen
I. Ehmer MSc (NIN)
N.A.F. Eijsker
W. van Elzelingen
E.A. Fridgeirsson
J.N. Goedhoop
T.F. Goldschmidt
M.I.C. de Haan MSc
I.J. Jager
W.A. van Leeuwen
N. Levar MSc
L.C. Liebrand
C.A.B. Molenaar
P. Ooms
M.S. Oudijn MD
M.M. van der Pol
D. Scheepens MD
A.E. Schröder MD
R. Smolders
A.L. van der Straten
J.F.M. Strous
C.A. Turbyne
P.L.M. Walta
P.M. van Westen MA MSc
Y.M. Wong
M. van der Linden (UvA)
R. Schippers (VU)

Other research related activities
  • Board of directors / Trustees / Supervisory board, Amsterdam Brain & Cognition (ABC)
  • Board of directors / Trustees / Supervisory board, Board of the Senate of the University of Amsterdam
  • Board of directors / Trustees / Supervisory board, Spinozacentrum
  • Board of directors / Trustees / Supervisory board, ‘Stichting Folia Civiatis’
  • Board of directors / Trustees / Supervisory board, Ipse de Bruggen
  • Contribution to guidelines and protocols, DSM V
  • Membership of advisory board / Consultant, Nederlandse Hersenbank
  • Membership of medical or scientific committee, International DBS consortium of psychiatric disorders
  • Membership of medical or scientific committee, International OCD spectrum disorders consortium
  • Membership of medical or scientific committee, Collegium International Neuropsychopharmacologicum
  • Membership of medical or scientific committee, European Collegium of Neuropsychopharmacology
  • Membership of medical or scientific committee, Nederlandse Vereniging voor Psychiatrie
  • Membership of medical or scientific committee, International Society for Neuroscience (SNF)
  • Membership of medical or scientific committee, International OCD genetics consortium
  • Membership of medical or scientific committee, Scientific Advisory Group CNS EMEA
  • Membership, Kenniskamer Human Enhancement
Current research funding
  • AMC
  • Europese Unie
  • Hogeschool Rotterdam
  • Nederlands Herseninstituut
  • NWO
  • Universiteit van Amsterdam-ABC
  • ZonMw