Researchers

  • Male

Drs. R.J.T. Mocking

Position: PhD student
Main activities: Research
Specialisation: Biological psychiatry, Mood disorders
foto
Focus of research:

The focus of my research activities is primarily the interactions between fatty acid metabolism and other pathophysiological mechanisms in recurrent major depressive disorder. In the DELTA study, we compare fatty acid metabolism between patients and controls, and investigate associations with hypothalamic-pituitary-adrenal-axis functioning, one-carbon metabolism, and genetic polymorphisms. In the FASCINATED study, we additionally link fatty acid metbolism with brain imaging parameters by (f)MRI, and assess the predictive power of these interactions for prospective depressive recurrences. In the DELPHI study, we explore connections between fatty acid metabolism and the serotonin neurotransmitter system. Finally, in coorportation with Tilburg University, we analyze data of a randomized controlled trial investigating the effect of add-on fatty acid supplementation on biological parameters in patients with major depressive disorder and co-morbid diabetes.

For more information (in Dutch), see: www.amcpsychiatrie-depressie.nl/DELTA-Neuroimaging

AMC themes: Neurological & Psychiatric Disorders
Departments: Psychiatry: Adult Psychiatry
de Vries GJ, Mocking R, Assies J, Schene A, Olff M, Plasma lipoproteins in posttraumatic stress disorder patients compared to healthy controls and their associations with the HPA- and HPT-axis. PSYCHONEUROENDOCRINO 2017;86:209-217 [PubMed]
Figueroa CA, Mocking RJT, van Wingen G, Martens S, Ruhé HG , Schene AH, Aberrant default-mode network-hippocampus connectivity after sad memory-recall in remitted-depression. SOC COGN AFFECT NEUR 2017;ahead of print [PubMed]
Mocking RJT , Nap TS, Westerink AM, Assies J , Vaz FM, Koeter MWJ, Ruhé HG, Schene AH, Biological profiling of prospective antidepressant response in major depressive disorder: Associations with (neuro)inflammation, fatty acid metabolism, and amygdala-reactivity. PSYCHONEUROENDOCRINO 2017;79:84-92 [PubMed]
Servaas MN, Riese H, Renken RJ, Wichers M, Bastiaansen JA, Figueroa CA, Geugies H, Mocking RJT, Geerligs L, Marsman JBC, Aleman A, Schene AH, Schoevers RA, Ruhé HG, Associations between Daily Affective Instability and Connectomics in Functional Subnetworks in Remitted Patients with Recurrent Major Depressive Disorder. NEUROPSYCHOPHARMACOL 2017;-:- [PubMed]
Vermeulen E, Stronks K, Visser M, Brouwer IA, Snijder MB, Mocking RJT , Derks EM, Schene AH, Nicolaou M, Dietary pattern derived by reduced rank regression and depressive symptoms in a multi-ethnic population: the HELIUS study. EUR J CLIN NUTR 2017;71 (8):987-994 [PubMed]
de Vries GJ, Mocking R, Lok A , Assies J, Schene A, Olff M, Fatty acid concentrations in patients with posttraumatic stress disorder compared to healthy controls. J AFFECT DISORDERS 2016;205:351-359 [PubMed]
Korucuoglu O, Gladwin TE, Baas F, Mocking RJT, Ruhé HG , Groot PFC, Wiers RW, Neural response to alcohol taste cues in youth: effects of the OPRM1 gene. ADDICT BIOL 2016;ahead of print [PubMed]
Medema S, Mocking RJT, Koeter MWJ, Vaz FM, Meijer C, de Haan L, van Beveren NJM, Kahn R, van Os J, Wiersma D, Bruggeman R, Cahn W, Myin-Germeys I, Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls. SCHIZOPHRENIA BULL 2016;42 (2):358-368 [PubMed]
Mocking RJT, Doedens P, Medicamenteuze behandeling van het metabool syndroom. NURSE ACADEMY GGZ 2016;- (2):29-34
Mocking RJT, Figueroa CA, Rive MM, Geugies H, Servaas MN, Assies J, Koeter MWJ, Vaz FM, Wichers M, van Straalen JP, de Raedt R, Bockting CLH, Harmer CJ, Schene AH, Ruhé HG, Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study. BMJ OPEN 2016;6 (3):e009510 [PubMed]
Mocking RJT , Harmsen I, Assies J , Koeter MWJ, Ruhé HG, Schene AH, Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. TRANSL PSYCHIAT 2016;6:e756 [PubMed]
Vermeulen E, Stronks K, Visser M, Brouwer IA, Schene AH, Mocking RJT, Colpo M, Bandinelli S, Ferrucci L, Nicolaou M, The association between dietary patterns derived by reduced rank regression and depressive symptoms over time: the Invecchiare in Chianti (InCHIANTI) study. BRIT J NUTR 2016;115 (12):2145-2153 [PubMed]
Assies J, Mocking RJT, Lok A , Koeter MWJ, Bockting CLH, Visser I , Pouwer F, Ruhé HG , Schene AH, Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: Implications for co-morbidity with cardiovascular disease. PSYCHIAT RES 2015;229 (3):992-998 [PubMed]
de Vries GJ, Lok A , Mocking R, Assies J, Schene A, Olff M, Altered one-carbon metabolism in posttraumatic stress disorder. J AFFECT DISORDERS 2015;184:277-285 [PubMed]
Mocking RJ, Metabool syndroom in de ggz: diagnostiek, oorzaken, gevolgen en behandeling. NURSE ACADEMY GGZ 2015;2015 (1):onbekend
Mocking RJT , Pellikaan CM, Lok A , Assies J , Ruhé HG, Koeter MW, Visser I, Bockting CL, Olff M, Schene AH, DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence?. PSYCHONEUROENDOCRINO 2015;59:91-101 [PubMed]
Mocking RJT, Verburg HF, Westerink AM, Assies J, Vaz FM, Koeter MWJ, Ruhé HG , Schene AH, Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response. PSYCHONEUROENDOCRINO 2015;59:1-13 [PubMed]
Rive MM, Mocking RJT, Koeter MWJ, van Wingen G, de Wit SJ, van den Heuvel OA, Veltman DJ, Ruhé HG , Schene AH, State-Dependent Differences in Emotion Regulation Between Unmedicated Bipolar Disorder and Major Depressive Disorder. JAMA PSYCHIAT 2015;72 (7):687-696 [PubMed]
Ruhé HG , Khoenkhoen SJ, Ottenhof KW, Koeter MW, Mocking RJT, Schene AH, Longitudinal effects of the SSRI paroxetine on salivary cortisol in Major Depressive Disorder. PSYCHONEUROENDOCRINO 2015;52:261-271 [PubMed]
Assies J , Mocking RJT , Lok A , Ruhé HG, Pouwer F, Schene AH, Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity. ACTA PSYCHIAT SCAND 2014;130 (3):163-180 [PubMed]
Lok A , Mocking RJT , Assies J , Koeter MW, Bockting CL, de Vries GJ, Visser I, Derks EM, Kayser M, Schene AH, The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state?. J AFFECT DISORDERS 2014;166:115-123 [PubMed]
Mocking RJT, Wever SA, Pflanz CP, Pringle A, Parsons E, McTavish SF, Cowen PJ, Harmer CJ, Schene AH, Effects of short-term varenicline administration on cortisol in healthy, non-smoking adults: a randomized, double-blind, study. PSYCHOPHARMACOLOGY 2014;231 (1):143-148 [PubMed]
Bockting CLH, Mocking RJ, Lok A , Koeter MWJ, Schene AH, Therapygenetics: the 5HTTLPR as a biomarker for response to psychological therapy?. MOL PSYCHIATR 2013;18 (7):744-745 [PubMed]
Lok A , Bockting CLH, Koeter MWJ, Snieder H, Assies J , Mocking RJT , Vinkers CH, Kahn RS, Boks MP, Schene AH, Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression. TRANSL PSYCHIAT 2013;3:e288 [PubMed]
Mocking RJ, Patrick Pflanz C, Pringle A, Parsons E, McTavish SF, Cowen PJ, Harmer CJ, Effects of Short-Term Varenicline Administration on Emotional and Cognitive Processing in Healthy, Non-Smoking Adults: A Randomized, Double-Blind, Study. NEUROPSYCHOPHARMACOL 2013;38 (3):476-484 [PubMed]
Mocking RJT, Lok A , Assies J, Koeter MWJ, Visser I , Ruhé HG , Bockting CLH, Schene AH, Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference. PLOS ONE 2013;8 (12):e82980 [PubMed]
Mocking RJT, Ruhé HG , Assies J, Lok A , Koeter MWJ, Visser I , Bockting CLH, Schene AH, Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. PSYCHONEUROENDOCRINO 2013;38 (9):1607-1617 [PubMed]
Mocking RJT , Schene AH, In het kort: Interventie voor gewichtsverlies effectief bij patiënten met ernstige psychiatrische aandoeningen. NED TIJDSCHR GENEESKD 2013;157:A6446
Assies H, Mocking RJT, Associatie tussen metabool syndroom en psychiatrische ziekten: focus op vetzuren en het oxidatief metabolisme. Een overzicht van de huidige stand van zaken.. PSYFAR 2012;1:16-23
Lok A , Assies J, Koeter MWJ, Bockting CLH, Wouters LF, Mocking RJT, Schene AH, Sustained medically unexplained physical symptoms in euthymic patients with recurrent depression: Predictive value for recurrence and associations with omega 3- and 6 fatty acids and 5-HTTLPR?. J AFFECT DISORDERS 2012;136 (3):604-611 [PubMed]
Lok A , Mocking RJT, Ruhé HG , Visser I , Koeter MWJ, Assies J, Bockting CLH, Olff M, Schene AH, Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression. PSYCHONEUROENDOCRINO 2012;37 (7):892-902 [PubMed]
Mocking RJT, Assies J, Bot M, Jansen EHJM, Schene AH, Pouwer F, Biological Effects of Add-On Eicosapentaenoic Acid Supplementation in Diabetes Mellitus and Co-Morbid Depression: A Randomized Controlled Trial. PLOS ONE 2012;7 (11):e49431 [PubMed]
Mocking RJT, Assies J, Koeter MWJ, Ruhé HG , Lok A , Schene AH, Bimodal Distribution of Fatty Acids in Recurrent Major Depressive Disorder. BIOL PSYCHIAT 2012;71 (1):E3-E5 [PubMed]
Mocking RJT, Assies J, Lok A , Ruhé HG , Koeter MWJ, Visser I , Bockting CLH, Schene AH, Statistical Methodological Issues in Handling of Fatty Acid Data: Percentage or Concentration, Imputation and Indices. LIPIDS 2012;47 (5):541-547 [PubMed]
Assies J, Mocking RJT, Pouwer F, Maternal depression and child development after prenatal DHA supplementation. JAMA-J AM MED ASSOC 2011;305 (4):360; author reply 360-360; author reply 361 [PubMed]
Assies J, Pouwer F, Lok A , Mocking RJT, Bockting CLH, Visser I , Abeling NGGM, Duran M, Schene AH, Plasma and Erythrocyte Fatty Acid Patterns in Patients with Recurrent Depression: A Matched Case-Control Study. PLOS ONE 2010;5 (5):e10635 [PubMed]
Key publications

Mocking RJ, Patrick Pflanz C, Pringle A, Parsons E, McTavish SF, Cowen PJ, Harmer CJ, Effects of Short-Term Varenicline Administration on Emotional and Cognitive Processing in Healthy, Non-Smoking Adults: A Randomized, Double-Blind, Study. NEUROPSYCHOPHARMACOL 2013;38 (3):476-484 [PubMed]
Mocking RJT, Assies J, Koeter MWJ, Ruhé HG , Lok A , Schene AH, Bimodal Distribution of Fatty Acids in Recurrent Major Depressive Disorder. BIOL PSYCHIAT 2012;71 (1):E3-E5 [PubMed]
Mocking RJT, Assies J, Lok A , Ruhé HG , Koeter MWJ, Visser I , Bockting CLH, Schene AH, Statistical Methodological Issues in Handling of Fatty Acid Data: Percentage or Concentration, Imputation and Indices. LIPIDS 2012;47 (5):541-547 [PubMed]
Bockting CLH, Mocking RJ, Lok A , Koeter MWJ, Schene AH, Therapygenetics: the 5HTTLPR as a biomarker for response to psychological therapy?. MOL PSYCHIATR 2013;18 (7):744-745 [PubMed]
Assies J, Mocking RJT, Pouwer F, Maternal depression and child development after prenatal DHA supplementation. JAMA-J AM MED ASSOC 2011;305 (4):360; author reply 360-360; author reply 361 [PubMed]


All Publications

Curriculum Vitae

Available on request

Research programmes

Prof. dr. W. van den Brink MD PhD (Addiction: pathogenesis, mechanisms of relapse and treatment effectiveness)

Other research related activities
  • Research Assistant, Tilburg University
  • Research Intern, University of Oxford
Current research funding
  • AMC