Researchers

  • Female

Drs. J.L. Frijling

Position: PhD student
Main activities: Research
Specialisation: psychotrauma, PTSD, oxytocin, stress, neuroimaging, clinical research
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Focus of research:

Mainly involved in conducting a clinical and neuroimaging study on the effects of intranasal oxytocin administration in recently traumatized individuals at increased risk of developing post-traumatic stress disorder (PTSD).

The clinical study is a multicenter randomized double-blind placebo-controlled trial in patients who were recently exposed to a traumatic event and were treated at the Emergency Department of one of our participating hospitals. We assess the efficacy of intranasal oxytocin administration to prevent PTSD development in those individuals at increased risk of developing PTSD. The neuroimaging study is a cross-sectional study aimed to study the acute effects of intranasal oxytocin administration (vs. placebo) on traumatic stress reactivity in the brain in this population. In addition, both studies investigate the effects of intranasal oxytocin administration on a variety of neuroendocrine, physiological, and behavioral measures.

 

AMC themes: Neurological & Psychiatric Disorders
Departments: Psychiatry: Adult Psychiatry
Frijling JL, Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals. EUR J PSYCHOTRAUMATO 2017;8 (1):1302652 [PubMed]
Frijling JL. Preventing PTSD with oxytoxin: Effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals. S.l.: s.n.; 2017. 251p. ISBN 978-94-028-0505-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Olff M, Veltman DJ; copromotor(s): van Zuiden M)
Koch SBJ, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M, Decreased uncinate fasciculus tract integrity in male and female patients with PTSD: a diffusion tensor imaging study. J PSYCHIATR NEUROSCI 2017;42 (5):331-342 [PubMed]
Nawijn L, van Zuiden M, Koch SBJ, Frijling JL, Veltman DJ, Olff M, Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder. SOC COGN AFFECT NEUR 2017;12 (2):212-223 [PubMed]
van Zuiden M, Frijling JL, Nawijn L, Koch SBJ, Goslings JC, Luitse JS, Biesheuvel TH, Honig A, Veltman DJ, Olff M, Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients. BIOL PSYCHIAT 2017;81 (12):1030-1040 [PubMed]
Frijling JL, van Zuiden M, Koch SBJ, Nawijn L, Veltman DJ, Olff M, Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals. SOC COGN AFFECT NEUR 2016;11 (2):327-336 [PubMed]
Frijling JL, van Zuiden M, Koch SBJ, Nawijn L, Veltman DJ, Olff M, Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals. NEUROPSYCHOPHARMACOL 2016;41 (5):1286-1296 [PubMed]
Koch SBJ, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M, ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW. DEPRESS ANXIETY 2016;33 (7):592-605 [PubMed]
Koch SBJ, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M, Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder. NEUROPSYCHOPHARMACOL 2016;41 (8):2041-2051 [PubMed]
Koch SB, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M, Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients. NEUROPSYCHOPHARMACOL 2016;41 (6):1495-1504 [PubMed]
Nawijn L, van Zuiden M, Koch SBJ, Frijling JL, Veltman DJ, Olff M, Intranasal oxytocin enhances neural processing of monetary reward and loss in post-traumatic stress disorder and traumatized controls. PSYCHONEUROENDOCRINO 2016;66:228-237 [PubMed]
Nawijn L, van Zuiden M, Frijling JL, Koch SBJ, Veltman DJ, Olff M, Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia. NEUROSCI BIOBEHAV R 2015;51:189-204 [PubMed]
Olff M, van Zuiden M, Koch SBJ, Nawijn L, Frijling JL, Veltman DJ, Intranasal oxytocin: miracle cure after trauma?. EUR J PSYCHOTRAUMATO 2015;6 (1):27631
Frijling JL, van Zuiden M, Koch SBJ, Nawijn L, Goslings JC, Luitse JS, Biesheuvel TH, Honig A, Bakker FC, Denys D, Veltman DJ, Olff M, Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial. BMC PSYCHIATRY 2014;14 (1):92 [PubMed]
Koch SBJ, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M, Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes. PSYCHONEUROENDOCRINO 2014;40:242-256 [PubMed]
Olff M, Koch SBJ, Nawijn L, Frijling JL, van Zuiden M, Veltman DJ, Social support, oxytocin, and PTSD. EUR J PSYCHOTRAUMATO 2014;5 (1):26513 [PubMed]
Frijling JL, van Zuiden M, Koch S, Nawijn L, Veltman D, Olff M. Promoting resilience after trauma: clinical applications of intranasal oxytocin and affiliation development in preventing PTSD in: Kent M, Davis M C., Reich J W., editors. Handbook of Resilience: Approaches to Stress and Trauma. New York: Routledge; 2013., p. 299
Olff M, Frijling JL, Kubzansky LD, Bradley B, Ellenbogen MA, Cardoso C, Bartz JA, Yee JR, van Zuiden M, The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences. PSYCHONEUROENDOCRINO 2013;38 (9):1883-1894 [PubMed]
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