Researchers

  • Male

E.R. Gamazon

Position: Other
Main activities: Research
Specialisation: Genomics, Statistical Genetics, Genetic Epidemiology, Bioinformatics, Psychiatry, Cancer Biology
foto
Focus of research:

At the intersection of computational biology, statistical genetics, and functional genomics, our primary research interest is in developing and extending methods for elucidating the genetic architecture of complex disorders and pharmacologic phenotypes. An ongoing project involves the genetics of gene expression and the use of expression quantitative trait loci (eQTLs) to expand on genetic association studies.

AMC themes: Neurological & Psychiatric Disorders, Public Health & Epidemiology
Departments: Clinical Epidemiology, Biostatistics and Bioinformatics, Psychiatry: Adult Psychiatry
Chamessian A, van de Ven T, Buchheit T, Hsia HL, McDuffie M, Gamazon ER, Walsh C, Bruehl S, Buckenmaier CT 3rd, Shaw A, Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain. PAIN 2017;158 (1):68-74 [PubMed]
Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE, Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. PHARMACOGENOMICS J 2017;17 (2):137-145 [PubMed]
Derks EM, Zwinderman AH, Gamazon ER, The Relation Between Inflation in Type-I and Type-II Error Rate and Population Divergence in Genome-Wide Association Analysis of Multi-Ethnic Populations. BEHAV GENET 2017;47 (3):360-368 [PubMed]
Gamazon ER, Konkashbaev A, Derks EM, Cox NJ, Lee Y, Evidence of selection on splicing-associated loci in human populations and relevance to disease loci mapping. SCI REP-UK 2017;7 (1):5980 [PubMed]
Hernandez W, Gamazon ER, Aquino-Michaels K, Smithberger E, O'Brien TJ, Harralson AF, Tuck M, Barbour A, Cavallari LH, Perera MA, Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans. J THROMB HAEMOST 2017;15 (4):735-743 [PubMed]
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK, Teslovich TM, Blackwell TW, Bork-Jensen J, Burtt NP, Chen Y, Green T, Hartl C, Kang HM, Kumar A, Ladenvall C, Ma C, Moutsianas L, Pearson RD, Perry JRB, Rayner NW, Robertson NR, Scott LJ, van de Bunt M, Eriksson JG, Jula A, Koskinen S, Lehtimäki T, Palotie A, Raitakari OT, Jacobs SBR, Wessel J, Chu AY, Scott RA, Goodarzi MO, Blancher C, Buck G, Buck D, Chines PS, Gabriel S, Gjesing AP, Groves CJ, Hollensted M, Huyghe JR, Jackson AU, Jun G, Justesen JM, Mangino M, Murphy J, Neville M, Onofrio R, Small KS, Stringham HM, Trakalo J, Banks E, Carey J, Carneiro MO, DePristo M, Farjoun Y, Fennell T, Goldstein JI, Grant G, Hrabé de Angelis M, Maguire J, Neale BM, Poplin R, Purcell S, Schwarzmayr T, Shakir K, Smith JD, Strom TM, Wieland T, Lindstrom J, Brandslund I, Christensen C, Surdulescu GL, Lakka TA, Doney ASF, Nilsson P, Wareham NJ, Langenberg C, Varga TV, Franks PW, Rolandsson O, Rosengren AH, Farook VS, Thameem F, Puppala S, Kumar S, Lehman DM, Jenkinson CP, Curran JE, Hale DE, Fowler SP, Arya R, DeFronzo RA, Abboud HE, Syvänen AC, Hicks PJ, Palmer ND, Ng MCY, Bowden DW, Freedman BI, Esko T, Mägi R, Milani L, Mihailov E, Metspalu A, Narisu N, Kinnunen L, Bonnycastle LL, Swift A, Pasko D, Wood AR, Fadista J, Pollin TI, Barzilai N, Atzmon G, Glaser B, Thorand B, Strauch K, Peters A, Roden M, Müller-Nurasyid M, Liang L, Kriebel J, Illig T, Grallert H, Gieger C, Meisinger C, Lannfelt L, Musani SK, Griswold M, Taylor HA Jr, Wilson G Sr, Correa A, Oksa H, Scott WR, Afzal U, Tan ST, Loh M, Chambers JC, Sehmi J, Kooner JS, Lehne B, Cho YS, Lee JY, Han BG, Käräjämäki A, Qi Q, Qi L, Huang J, Hu FB, Melander O, Orho-Melander M, Below JE, Aguilar D, Wong TY, Liu J, Khor CC, Chia KS, Lim WY, Cheng CY, Chan E, Tai ES, Aung T, Linneberg A, Isomaa B, Meitinger T, Tuomi T, Hakaste L, Kravic J, Jørgensen ME, Lauritzen T, Deloukas P, Stirrups KE, Owen KR, Farmer AJ, Frayling TM, O'Rahilly SP, Walker M, Levy JC, Hodgkiss D, Hattersley AT, Kuulasmaa T, Stančáková A, Barroso I, Bharadwaj D, Chan J, Chandak GR, Daly MJ, Donnelly PJ, Ebrahim SB, Elliott P, Fingerlin T, Froguel P, Hu C, Jia W, Ma RCW, McVean G, Park T, Prabhakaran D, Sandhu M, Scott J, Sladek R, Tandon N, teo YY, Zeggini E, Watanabe RM, Koistinen HA, Kesaniemi YA, Uusitupa M, Spector TD, Salomaa V, Rauramaa R, Palmer CNA, Prokopenko I, Morris AD, Bergman RN, Collins FS, Lind L, Ingelsson E, Tuomilehto J, Karpe F, Groop L, Jørgensen T, Hansen T, Pedersen O, Kuusisto J, Abecasis G, Bell GI, Blangero J, Cox NJ, Duggirala R, Seielstad M, Wilson JG, Dupuis J, Ripatti S, Hanis CL, Florez JC, Mohlke KL, Meigs JB, Laakso M, Morris AP, Boehnke M, Altshuler D, McCarthy MI, Gloyn AL, Lindgren CM, A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. DIABETES 2017;66 (7):2019-2032 [PubMed]
Wei WQ, Bastarache LA, Carroll RJ, Marlo JE, Osterman TJ, Gamazon ER, Cox NJ, Roden DM, Denny JC, Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record. PLOS ONE 2017;12 (7):e0175508 [PubMed]
Wheeler HE, Gamazon ER, Frisina RD, Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman DR, Hamilton RJ, Vaughn DJ, Beard CJ, Fung C, Kollmannsberger C, Kim J, Mushiroda T, Kubo M, Ardeshir-Rouhani-Fard S, Einhorn LH, Cox NJ, Dolan ME, Travis LB, Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. CLIN CANCER RES 2017;23 (13):3325-3333 [PubMed]
Below JE, Parra EJ, Gamazon ER, Torres J, Krithika S, Candille S, Lu Y, Manichakul A, Peralta-Romero J, Duan Q, Li Y, Morris AP, Gottesman O, Bottinger E, Wang XQ, Taylor KD, Ida Chen YD, Rotter JI, Rich SS, Loos RJF, Tang H, Cox NJ, Cruz M, Hanis CL, Valladares-Salgado A, Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs. SCI REP-UK 2016;6:19429 [PubMed]
Chang SW, McDonough CW, Gong Y, Johnson TA, Tsunoda T, Gamazon ER, Perera MA, Takahashi A, Tanaka T, Kubo M, Pepine CJ, Johnson JA, Cooper-DeHoff RM, Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes. PHARMACOGENOMICS J 2016;ahead of print [PubMed]
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Fernandez Tajes J, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stancáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, van der Schouw YT, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA Jr, Thameem F, Wilson G Sr, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, Hrabé de Angelis M, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JCN, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuler D, McCarthy MI, The genetic architecture of type 2 diabetes. NATURE 2016;536 (7614):41-+ [PubMed]
Gamazon ER. Alternative Splicing and Genome Evolution in: N. N, editor. Encyclopedia of life sciences (eLS). Chichester: John Wiley & Sons Ltd; 2005. 2016, p. a0026311
Gamazon ER. The genetic architecture of neuropsychiatric traits: mechanism, polygenicity, and genome function. S.l.: s.n.; 2016. 536p. ISBN 978-94-028-0300-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Derks EM, Zwinderman AH; copromotor(s): )
Geeleher P, Gamazon ER, Seoighe C, Cox NJ, Huang RS, Consistency in large pharmacogenomic studies. NATURE 2016;540 (7631):E1-E2 [PubMed]
Hernandez W, Gamazon ER, Smithberger E, O'Brien TJ, Harralson AF, Tuck M, Barbour A, Kittles RA, Cavallari LH, Perera MA, Novel genetic predictors of venous thromboembolism risk in African Americans. BLOOD 2016;127 (15):1923-1929 [PubMed]
Hillenmeyer S, Davis LK, Gamazon ER, Cook EH, Cox NJ, Altman RB, STAMS: STRING-assisted module search for genome wide association studies and application to autism. BIOINFORMATICS 2016;32 (24):3815-3822 [PubMed]
Hungate EA, Vora SR, Gamazon ER, Moriyama T, Best T, Hulur I, Lee Y, Evans TJ, Ellinghaus E, Stanulla M, Rudant J, Orsi L, Clavel J, Milne E, Scott RJ, Pui CH, Cox NJ, Loh ML, Yang JJ, Skol AD, Onel K, A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology. NAT COMMUN 2016;7:10635 [PubMed]
Huo D, Feng Y, Haddad S, Zheng Y, Yao S, Han YJ, Ogundiran TO, Adebamowo C, Ojengbede O, Falusi AG, Zheng W, Blot W, Cai Q, Signorello L, John EM, Bernstein L, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Nathanson KL, Domchek SM, Rebbeck TR, Ruiz-Narváez EA, Sucheston-Campbell LE, Bensen JT, Simon MS, Hennis A, Nemesure B, Leske MC, Ambs S, Chen LS, Qian F, Gamazon ER, Lunetta KL, Cox NJ, Chanock SJ, Kolonel LN, Olshan AF, Ambrosone CB, Olopade OI, Palmer JR, Haiman CA, Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. HUM MOL GENET 2016;25 (21):4835-4846 [PubMed]
Wang J, Gamazon ER, Pierce BL, Stranger BE, Im HK, Gibbons RD, Cox NJ, Nicolae DL, Chen LS, Imputing Gene Expression in Uncollected Tissues Within and Beyond GTEx. AM J HUM GENET 2016;98 (4):697-708 [PubMed]
Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, Buia SA, Compton CC, Deluca DS, Peter-Demchok J, Gelfand ET, Guan P, Korzeniewski GE, Lockhart NC, Rabiner CA, Rao AK, Robinson KL, Roche NV, Sawyer SJ, Segrè AV, Shive CE, Smith AM, Sobin LH, Undale AH, Valentino KM, Vaught J, Young TR, Moore HM [Contributors: Barker L, Basile M, Battle A, Boyer J, Bradbury D, Bridge JP, Brown A, Burges R, Choi C, Colantuoni D, Cox N, Dermitzakis ET, Derr LK, Dinsmore MJ, Erickson K, Fleming J, Flutre T, Foster BA, Gamazon ER, Getz G, Gillard BM, Guigo R, Hambright KW, Hariharan P, Hasz R, Im HK, Jewell S, Karasik E, Kellis M, Kheradpour P, Koester S, Koller D, Konkashbaev A, Lappalainen T, Little R, Liu J, Lo E, Lonsdale JT, Lu C, MacArthur DG, Magazine H, Maller JB, Marcus Y, Mash DC, McCarthy MI, McLean J, Mestichelli B, Miklos M, Monlong J, Mosavel M, Moser MT, Mostafavi S, Nicolae DL, Pritchard J, Qi L, Ramsey K, Rivas MA, Robles BE, Rohrer DC, Salvatore M, Sammeth M, Seleski J, Shad S, Siminoff LA, Stephens M, Struewing J, Sullivan T, Sullivan S, Syron J, Tabor D, Taherian M, Tejada J, Temple GF, Thomas JA, Thomson AW, Tidwell D, Traino HM, Tu Z, Valley DR, Volpi S, Walters GD, Ward LD, Wen X, Winckler W, Wu S, Zhu J]] , A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project. BIOPRESERV BIOBANK 2015;13 (5):311-319 [PubMed]
Evans PD, Mueller KL, Gamazon ER, Cox NJ, Tomblin JB, A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13. GENES BRAIN BEHAV 2015;14 (5):387-397 [PubMed]
Gamazon ER, Stranger BE, The impact of human copy number variation on gene expression. BRIEF FUNCT GENOMICS 2015;14 (5):352-357 [PubMed]
Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, Nicolae DL, Cox NJ, Im HK, A gene-based association method for mapping traits using reference transcriptome data. NAT GENET 2015;47 (9):1091-+ [PubMed]
Hulur I, Gamazon ER, Skol AD, Xicola RM, Llor X, Onel K, Ellis NA, Kupfer SS, Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC GENOMICS 2015;16:138 [PubMed]
Kim YJ, Lee J, Kim BJ, Park T [Contributors: Abecasis G, Almeida M, Altshuler D, Asimit JL, Atzmon G, Barber M, Barzilai N, Beer NL, Bell GI, Below J, Blackwell T, Blangero J, Boehnke M, Bowden DW, Burtt N, Chambers J, Chen H, Chen P, Chines PS, Choi S, Churchhouse C, Cingolani P, Cornes BK, Cox N, Day-Williams AG, Duggirala R, Dupuis J, Dyer T, Feng S, Fernandez-Tajes J, Ferreira T, Fingerlin TE, Flannick J, Florez J, Fontanillas P, Frayling TM, Fuchsberger C, Gamazon ER, Gaulton K, Ghosh S, Glaser B, Gloyn A, Grossman RL, Grundstad J, Hanis C, Heath A, Highland H, Horikoshi M, Huh IS, Huyghe JR, Ikram K, Jablonski KA, Jun G, Kato N, Kim J, Kim YJ, Kim BJ, Lee J, King CR, Kooner J, Kwon MS, Im HK, Laakso M, Lam KKY, Lee J, Lee S, Lee S, Lehman DM, Li H, Lindgren CM, Liu X, Livne OE, Locke AE, Mahajan A, Maller JB, Manning AK, Maxwell TJ, Mazoure A, McCarthy MI, Meigs JB, Min B, Mohlke KL, Morris AP, Musani S, Nagai Y, Ng MCY, Nicolae D, Oh S, Palmer N, Park T, Pollin TI, Prokopenko I, Reich D, Rivas MA, Scott LJ, Seielstad M, Cho YS, Sim X, Sladek R, Smith P, Tachmazidou I, Tai ES, teo YY, Teslovich TM, Torres J, Trubetskoy V, Willems SM, Williams AL, Wilson JG, Wiltshire S, Won S, Wood AR, Xu W, Yoon J, Zawistowski M, Zeggini E, Zhang W, Zöllner S]] , A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data. BMC GENOMICS 2015;16 (1):1109 [PubMed]
Kutny MA, Alonzo TA, Gamazon ER, Gerbing RB, Geraghty D, Lange B, Heerema NA, Sung L, Aplenc R, Franklin J, Raimondi SC, Hirsch BA, Konkashbaev A, Cox NJ, Onel K, Gamis AS, Meshinchi S, Ethnic variation of TET2 SNP rs2454206 and association with clinical outcome in childhood AML: a report from the Children's Oncology Group. LEUKEMIA 2015;29 (12):2424-2426 [PubMed]
Lenkala D, Gamazon ER, LaCroix B, Im HK, Huang RS, MicroRNA biogenesis and cellular proliferation. TRANSL RES 2015;166 (2):145-151 [PubMed]
Maitland ML, Xu CF, Cheng YC, Kistner-Griffin E, Ryan KA, Karrison TG, Das S, Torgerson D, Gamazon ER, Thomeas V, Levine MR, Wilson PA, Bing N, Liu Y, Cardon LR, Pandite LN, O'Connell JR, Cox NJ, Mitchell BD, Ratain MJ, Shuldiner AR, Identification of a Variant in KDR Associated with Serum VEGFR2 and Pharmacodynamics of Pazopanib. CLIN CANCER RES 2015;21 (2):365-372 [PubMed]
Pierson E, Koller D, Battle A, Mostafavi S, Ardlie KG, Getz G, Wright FA, Kellis M, Volpi S, Dermitzakis ET [Contributors: Ardlie KG, Deluca DS, Segrè AV, Sullivan TJ, Young TR, Gelfand ET, Trowbridge CA, Maller JB, Tukiainen T, Lek M, Ward LD, Kheradpour P, Iriarte B, Meng Y, Palmer CD, Winckler W, Hirschhorn J, Kellis M, MacArthur DG, Getz G, Shablin AA, Li G, Zhou YH, Nobel AB, Rusyn I, Wright FA, Lappalainen T, Ferreira PG, Ongen H, Rivas MA, Battle A, Mostafavi S, Monlong J, Sammeth M, Mele M, Reverter F, Goldmann J, Koller D, Guigo R, McCarthy MI, Dermitzakis ET, Gamazon ER, Im HK, Konkashbaev A, Nicolae DL, Cox NJ, Flutre T, Wen X, Stephens M, Pritchard JK, Tu Z, Zhang B, Huang T, Long Q, Lin L, Yang J, Zhu J, Liu J, Brown A, Mestichelli B, Tidwell D, Lo E, Salvatore M, Shad S, Thomas JA, Lonsdale JT, Choi C, Karasik E, Ramsey K, Moser MT, Foster BA, Gillard BM, Syron J, Fleming J, Magazine H, Hasz R, Walters GD, Bridge JP, Miklos M, Sullivan S, Barker LK, Traino H, Mosavel M, Siminoff LA, Valley DR, Rohrer DC, Jewel S, Branton P, Sobin LH, Qi L, Hariharan P, Wu S, Tabor D, Shive C, Smith AM, Buia SA, Undale AH, Robinson KL, Roche N, Valentino KM, Britton A, Burges R, Bradbury D, Hambright KW, Seleski J, Korzeniewski GE, Erickson K, Marcus Y, Tejada J, Taherian M, Lu C, Robles BE, Basile M, Mash DC, Volpi S, Struewing JP, Temple GF, Boyer J, Colantuoni D, Little R, Koester S, Carithers LJ, Moore HM, Guan P, Compton C, Sawyer SJ, Demchok JP, Vaught JB, Rabiner CA, Lockhart NC]] , Sharing and Specificity of Co-expression Networks across 35 Human Tissues. PLOS COMPUT BIOL 2015;11 (5):e1004220 [PubMed]
Rivas MA, Pirinen M, Conrad DF, Lek M, Tsang EK, Karczewski KJ, Maller JB, Kukurba KR, Deluca DS, Fromer M, Ferreira PG, Smith KS, Zhang R, Zhao F, Banks E, Poplin R, Ruderfer DM, Purcell SM, Tukiainen T, Minikel EV, Stenson PD, Cooper DN, Huang KH, Sullivan TJ, Nedzel J, Bustamante CD, Li JB, Daly MJ, Guigo R, Donnelly P, Ardlie K, Sammeth M, Dermitzakis ET, McCarthy MI, Montgomery SB, Lappalainen T, MacArthur DG [Contributors: Ardlie KG, Deluca DS, Segre AV, Sullivan TJ, Young TR, Gelfand ET, Trowbridge CA, Maller JB, Tukiainen T, Lek M, Ward LD, Kheradpour P, Iriarte B, Meng Y, Palmer CD, Esko T, Winckler W, Hirschhorn J, Kellis M, MacArthur DG, Getz G, Shablin AA, Li G, Zhou YH, Nobel AB, Rusyn I, Wright FA, Lappalainen T, Ferreira PG, Ongen H, Rivas MA, Battle A, Mostafavi S, Monlong J, Sammeth M, Mele M, Reverter F, Goldmann J, Koller D, Guigo R, McCarthy MI, Dermitzakis ET, Gamazon ER, Kyung H, Konkashbaev A, Nicolae DL, Cox NJ, Flutre T, Wen X, Stephens M, Pritchard JK, Tu Z, Zhang B, Huang T, Long Q, Lin L, Yang J, Zhu J, Liu J, Brown A, Mestichelli B, Tidwell D, Lo E, Salvatore M, Shad S, Thomas JA, Lonsdale JT, Choi C, Karasik E, Ramsey K, Moser MT, Foster BA, Gillard BM, Syron J, Fleming J, Magazine H, Hasz R, Walters GD, Bridge JP, Miklos M, Sullivan S, Barker LK, Traino H, Mosavel M, Siminoff LA, Valley DR, Rohrer DC, Jewel S, Branton P, Sobin LH, Barcus M, Qi L, Hariharan P, Wu S, Tabor D, Shive C, Smith AM, Buia SA, Undale AH, Robinson KL, Roche N, Valentino KM, Britton A, Burges R, Bradbury D, Hambright KW, Seleski J, Korzeniewski GE, Erickson K, Marcus Y, Tejada J, Taherian M, Lu C, Robles BE, Basile M, Mash DC, Volpi S, Struewing JP, Temple GF, Boyer J, Colantuoni D, Little R, Koester S, Carithers LJ, Moore HM, Guan P, Compton C, Sawyer SJ, Demchok JP, Vaught JB, Rabiner CA, Lockhart NC, Friedlander MR, 't Hoen PAC, Gonzlez-Porta M, Kurbatova N, Griebel T, Barann M, Wieland T, Greger L, van Iterson M, Almlof J, Ribeca P, Pulyakhina I, Esser D, Giger T, Tikhonov A, Sultan M, Bertier G, Lizano E, Buermans HPJ, Padioleau I, Schwarzmayr T, Karlberg O, Kilpinen H, Beltran S, Gut M, Kahlem K, Amstislavskiy V, Stegle O, Pirinen M, Montgomery SB, Donnelly P, Flicek P, Strom TM, Lehrach H, Schreiber S, Sudbrak R, Carracedo A, Antonarakis SE, Hasler R, Syvanen AC, van Ommen GJ, Brazma A, Meitinger T, Rosenstiel P, Gut IG, Estivill X]] , Effect of predicted protein-truncating genetic variants on the human transcriptome. SCIENCE 2015;348 (6235):666-669 [PubMed]
Yang J, Huang T, Petralia F, Long Q, Zhang B, Argmann C, Zhao Y, Mobbs CV, Schadt EE, Zhu J, Tu Z [Contributors: Ardlie KG, Deluca DS, Segrè AV, Sullivan TJ, Young TR, Gelfand ET, Trowbridge CA, Maller JB, Tukiainen T, Lek M, Ward LD, Kheradpour P, Iriarte B, Meng Y, Palmer CD, Winckler W, Hirschhorn J, Kellis M, MacArthur DG, Getz G, Shablin AA, Li G, Zhou YH, Nobel AB, Rusyn I, Wright FA, Lappalainen T, Ferreira PG, Ongen H, Rivas MA, Battle A, Mostafavi S, Monlong J, Sammeth M, Mele M, Reverter F, Goldman J, Koller D, Guigo R, McCarthy MI, Dermitzakis ET, Gamazon ER, Konkashbaev A, Nicolae DL, Cox NJ, Flutre T, Wen X, Stephens M, Pritchard JK, Lin L, Liu J, Brown A, Mestichelli B, Tidwell D, Lo E, Salvatore M, Shad S, Thomas JA, Lonsdale JT, Choi C, Karasik E, Ramsey K, Moser MT, Foster BA, Gillard BM, Syron J, Fleming J, Magazine H, Hasz R, Walters GD, Bridge JP, Miklos M, Sullivan S, Barker LK, Traino H, Mosavel M, Siminoff LA, Valley DR, Rohrer DC, Jewel S, Branton P, Sobin LH, Qi L, Hariharan P, Wu S, Tabor D, Shive C, Smith AM, Buia SA, Undale AH, Robinson KL, Roche N, Valentino KM, Britton A, Burges R, Bradbury D, Hambright KW, Seleski J, Korzeniewski GE, Erickson K, Marcus Y, Tejada J, Taherian M, Lu C, Robles BE, Basile M, Mash DC, Volpi S, Struewing J, Temple GF, Boyer J, Colantuoni D, Little R, Koester S, Carithers NLJ, Moore HM, Guan P, Compton C, Sawyer SJ, Demchok JP, Vaught JB, Rabiner CA, Lockhart NC]] , Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. SCI REP-UK 2015;5:15145 [PubMed]
Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JCC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SMJ, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-Vanderweele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HGM, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL, Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. AM J PSYCHIAT 2015;172 (1):82-93 [PubMed]
Zhang W, Gamazon ER, Zhang X, Konkashbaev A, Liu C, Szilágyi KL, Dolan ME, Cox NJ, SCAN database: facilitating integrative analyses of cytosine modification and expression QTL. DATABASE-OXFORD 2015;2015:bav025 [PubMed]
[Contributors: Ardlie KG, Deluca DS, Segrè AV, Sullivan TJ, Young TR, Gelfand ET, Trowbridge CA, Maller JB, Tukiainen T, Lek M, Ward LD, Kheradpour P, Iriarte B, Meng Y, Palmer CD, Esko T, Winckler W, Hirschhorn JN, Kellis M, MacArthur DG, Getz G, Shabalin AA, Li G, Zhou YH, Nobel AB, Rusyn I, Wright FA, Lappalainen T, Ferreira PG, Ongen H, Rivas MA, Battle A, Mostafavi S, Monlong J, Sammeth M, Melé M, Reverter F, Goldmann JM, Koller D, Guigó R, McCarthy MI, Dermitzakis ET, Gamazon ER, Im HK, Konkashbaev A, Nicolae DL, Cox NJ, Flutre T, Wen X, Stephens M, Pritchard JK, Tu Z, Zhang B, Huang T, Long Q, Lin L, Yang J, Zhu J, Liu J, Brown A, Mestichelli B, Tidwell D, Lo E, Salvatore M, Shad S, Thomas JA, Lonsdale JT, Moser MT, Gillard BM, Karasik E, Ramsey K, Choi C, Foster BA, Syron J, Fleming J, Magazine H, Hasz R, Walters GD, Bridge JP, Miklos M, Sullivan S, Barker LK, Traino HM, Mosavel M, Siminoff LA, Valley DR, Rohrer DC, Jewell SD, Branton PA, Sobin LH, Barcus M, Qi L, McLean J, Hariharan P, Um KS, Wu S, Tabor D, Shive C, Smith AM, Buia SA, Undale AH, Robinson KL, Roche N, Valentino KM, Britton A, Burges R, Bradbury D, Hambright KW, Seleski J, Korzeniewski GE, Erickson K, Marcus Y, Tejada J, Taherian M, Lu C, Basile M, Mash DC, Volpi S, Struewing JP, Temple GF, Boyer J, Colantuoni D, Little R, Koester S, Carithers LJ, Moore HM, Guan P, Compton C, Sawyer SJ, Demchok JP, Vaught JB, Rabiner CA, Lockhart NC]] , The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans. SCIENCE 2015;348 (6235):648-660 [PubMed]
Ahsan H, Halpern J, Kibriya MG, Pierce BL, Tong L, Gamazon E, McGuire V, Felberg A, Shi J, Jasmine F, Roy S, Brutus R, Argos M, Melkonian S, Chang-Claude J, Andrulis I, Hopper JL, John EM, Malone K, Ursin G, Gammon MD, Thomas DC, Seminara D, Casey G, Knight JA, Southey MC, Giles GG, Santella RM, Lee E, Conti D, Duggan D, Gallinger S, Haile R, Jenkins M, Lindor NM, Newcomb P, Michailidou K, Apicella C, Park DJ, Peto J, Fletcher O, dos Santos Silva I, Lathrop M, Hunter DJ, Chanock SJ, Meindl A, Schmutzler RK, Müller-Myhsok B, Lochmann M, Beckmann L, Hein R, Makalic E, Schmidt DF, Bui QM, Stone J, Flesch-Janys D, Dahmen N, Nevanlinna H, Aittomäki K, Blomqvist C, Hall P, Czene K, Irwanto A, Liu J, Rahman N, Turnbull C, Dunning AM, Pharoah P, Waisfisz Q, Meijers-Heijboer H, Uitterlinden AG, Rivadeneira F, Nicolae D, Easton DF, Cox NJ, Whittemore AS, A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. CANCER EPIDEM BIOMAR 2014;23 (4):658-669 [PubMed]
Daneshjou R, Gamazon ER, Burkley B, Cavallari LH, Johnson JA, Klein TE, Limdi N, Hillenmeyer S, Percha B, Karczewski KJ, Langaee T, Patel SR, Bustamante CD, Altman RB, Perera MA, Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans. BLOOD 2014;124 (14):2298-2305 [PubMed]
Darby A, Lertpiriyapong K, Sarkar U, Seneviratne U, Park DS, Gamazon ER, Batchelder C, Cheung C, Buckley EM, Taylor NS, Shen Z, Tannenbaum SR, Wishnok JS, Fox JG, Cytotoxic and Pathogenic Properties of Klebsiella oxytoca Isolated from Laboratory Animals. PLOS ONE 2014;9 (7):e100542 [PubMed]
Gamazon ER, Cox NJ, Davis LK, Structural Architecture of SNP Effects on Complex Traits. AM J HUM GENET 2014;95 (5):477-489 [PubMed]
Gamazon ER, Stranger BE, Genomics of alternative splicing: evolution, development and pathophysiology. HUM GENET 2014;133 (6):679-687 [PubMed]
Hart AB, Gamazon ER, Engelhardt BE, Sklar P, Kähler AK, Hultman CM, Sullivan PF, Neale BM, Faraone SV, de Wit H, Cox NJ, Palmer AA [Contributors: Anney R, Asherson P, Banaschewski T, Bayés M, Biederman J, Buitelaar JK, Casas M, Cormand B, Crosbie J, Doyle AE, Elia J, Faraone SV, Franke B, Kent L, Kuntsi J, Lesch KP, Loo SK, McGough JJ, Medland SE, Neale B, Nelson SF, Oades RD, Ramos-Quiroga JA, Reif A, Ribasés M, Rothenberger A, Schachar R, Smalley SL, Sonuga-Barke E, Steinhausen HC, Thapar A, Williams N]] , Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. P NATL ACAD SCI USA 2014;111 (16):5968-5973 [PubMed]
Hernandez W, Gamazon ER, Aquino-Michaels K, Patel S, O'Brien TJ, Harralson AF, Kittles RA, Barbour A, Tuck M, McIntosh SD, Douglas JN, Nicolae D, Cavallari LH, Perera MA, Ethnicity-specific pharmacogenetics: the case of warfarin in African Americans. PHARMACOGENOMICS J 2014;14 (3):223-228 [PubMed]
LaCroix B, Gamazon ER, Lenkala D, Im HK, Geeleher P, Ziliak D, Cox NJ, Huang RS, Integrative analyses of genetic variation, epigenetic regulation, and the transcriptome to elucidate the biology of platinum sensitivity. BMC GENOMICS 2014;15:292 [PubMed]
Lenkala D, LaCroix B, Gamazon ER, Geeleher P, Im HK, Huang RS, The impact of microRNA expression on cellular proliferation. HUM GENET 2014;133 (7):931-938 [PubMed]
Lertpiriyapong K, Whary MT, Muthupalani S, Lofgren JL, Gamazon ER, Feng Y, Ge Z, Wang TC, Fox JG, Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis. GUT 2014;63 (1):54-63 [PubMed]
Liu W, Ramírez J, Gamazon ER, Mirkov S, Chen P, Wu K, Sun C, Cox NJ, Cook E Jr, Das S, Ratain MJ, Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver. HUM MOL GENET 2014;23 (20):5558-5569 [PubMed]
Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, Rosen ED, Altshuler D [Contributors: Flannick J, Manning AK, Hartl C, Agarwala V, Fontanillas P, Green T, Banks E, DePristo M, Poplin R, Shakir K, Fennell T, Njølstad PR, Altshuler D, Burtt N, Gabriel S, Fuchsberger C, Kang HM, Sim X, Ma C, Locke A, Blackwell T, Jackson A, Teslovich TM, Stringham H, Chines P, Kwan P, Huyghe J, Tan A, Jun G, Stitzel M, Bergman RN, Bonnycastle L, Tuomilehto J, Collins FS, Scott L, Mohlke K, Abecasis G, Boehnke M, Strom T, Gieger C, Müller-Nurasyid M, Grallert H, Kriebel J, Ried J, de Angelis MH, Huth C, Meisinger C, Peters A, Rathmann W, Strauch K, Meitinger T, Kravic J, Algren P, Ladenvall C, Toumi T, Isomaa B, Groop L, Gaulton K, Moutsianas L, Rivas M, Pearson R, Mahajan A, Prokopenko I, Kumar A, Perry J, Howie B, van de Bunt M, Small K, Lindgren C, Lunter G, Robertson N, Rayner W, Morris A, Buck D, Hattersley A, Spector T, McVean G, Frayling T, Donnelly P, McCarthy M, Gupta N, Taylor H, Fox E, Newton-Cheh C, Wilson JG, O'Donnell CJ, Kathiresan S, Hirschhorn J, Seidman JG, Seidman C, Williams AL, Jacobs SBR, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Ripke S, Neale B, Stram DO, Fernández-López JC, Romero-Hidalgo S, Aguilar-Delfín I, Martínez-Hernández A, Centeno-Cruz F, Mendoza-Caamal E, Revilla-Monsalve C, Islas-Andrade S, Córdova E, Rodríguez-Arellano E, Soberón X, González-Villalpando ME, Monroe K, Wilkens L, Kolonel LN, Marchand LL, Riba L, Ordóñez-Sánchez ML, Rodríguez-Guillén R, Cruz-Bautista I, Rodríguez-Torres M, Muñoz-Hernández LL, Sáenz T, Gómez D, Alvirde U, Onofrio RC, Brodeur WM, Gage D, Murphy J, Franklin J, Mahan S, Ardlie K, Crenshaw AT, Winckler W, Florez JC, Haiman CA, Henderson BE, Aguilar-Salinas CA, González-Villalpando C, Orozco L, Tusié-Luna T, Almeida M, Asimit JL, Atzmon G, Barber M, Beer NL, Bell GI, Below J, Blackwell T, Blangero J, Bowden DW, Chambers J, Chen H, Chen P, Chines PS, Choi S, Cingolani P, Cornes BK, Cox N, Day-Williams AG, Duggirala R, Dupuis J, Dyer T, Feng S, Fernandez-Tajes J, Ferreira T, Fingerlin TE, Florez J, Frayling TM, Gamazon ER, Ghosh S, Gloyn A, Grossman RL, Grundstad J, Hanis C, Heath A, Highland H, Hirokoshi M, Huh IS, Huyghe JR, Ikram K, Jablonski KA, Jun YJK, Kato N, Kim J, King CR, Kooner J, Kwon MS, Im HK, Laakso M, Lam KKY, Lee J, Lee S, Lee S, Lehman DM, Li H, Lindgren CM, Liu X, Livne OE, Locke AE, Maller JB, Maxwell TJ, Mazoure A, McCarthy MI, Meigs JB, Min B, Mohlke KL, Musani S, Nagai Y, Ng MCY, Nicolae D, Oh S, Palmer N, Park T, Pollin TI, Reich D, Rivas MA, Scott LJ, Seielstad M, Cho YS, Tai ES, Sladek R, Smith P, Tachmazidou I, Torres J, Trubetskoy V, Willems SM, Wiltshire S, Won S, Wood AR, Xu W, teo YY, Yoon J, Lee JY, Zawistowski M, Zeggini E, Zhang W, Zöllner S, Estrada K, Mercader J, MacArthur D]] , Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. P NATL ACAD SCI USA 2014;111 (36):13127-13132 [PubMed]
Paré-Brunet L, Glubb D, Evans P, Berenguer-Llergo A, Etheridge AS, Skol AD, Di Rienzo A, Duan S, Gamazon ER, Innocenti F, Discovery and Functional Assessment of Gene Variants in the Vascular Endothelial Growth Factor Pathway. HUM MUTAT 2014;35 (2):227-235 [PubMed]
Paschou P, Yu D, Gerber G, Evans P, Tsetsos F, Davis LK, Karagiannidis I, Chaponis J, Gamazon E, Mueller-Vahl K, Stuhrmann M, Schloegelhofer M, Stamenkovic M, Hebebrand J, Noethen M, Nagy P, Barta C, Tarnok Z, Rizzo R, Depienne C, Worbe Y, Hartmann A, Cath DC, Budman CL, Sandor P, Barr C, Wolanczyk T, Singer H, Chou IC, Grados M, Posthuma D, Rouleau GA, Aschauer H, Freimer NB, Pauls DL, Cox NJ, Mathews CA, Scharf JM, Genetic association signal near NTN4 in Tourette syndrome. ANN NEUROL 2014;76 (2):310-315 [PubMed]
Pinto N, Gamazon ER, Antao N, Myers J, Stark AL, Konkashbaev A, Im HK, Diskin SJ, London WB, Ludeman SM, Maris JM, Cox NJ, Cohn SL, Dolan ME, Integrating Cell-Based and Clinical Genome-Wide Studies to Identify Genetic Variants Contributing to Treatment Failure in Neuroblastoma Patients. CLIN PHARMACOL THER 2014;95 (6):644-652 [PubMed]
Ramírez J, Kim TW, Liu W, Myers JL, Mirkov S, Owzar K, Watson D, Mulkey F, Gamazon ER, Stock W, Undevia S, Innocenti F, Ratain MJ, A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469. PHARMACOGENET GENOM 2014;24 (2):129-132 [PubMed]
Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA, Obesity-associated variants within FTO form long-range functional connections with IRX3. NATURE 2014;507 (7492):371-+ [PubMed]
Torres JM, Gamazon ER, Parra EJ, Below JE, Valladares-Salgado A, Wacher N, Cruz M, Hanis CL, Cox NJ, Cross-Tissue and Tissue-Specific eQTLs: Partitioning the Heritability of a Complex Trait. AM J HUM GENET 2014;95 (5):521-534 [PubMed]
Wheeler HE, Aquino-Michaels K, Gamazon ER, Trubetskoy VV, Dolan ME, Huang RS, Cox NJ, Im HK, Poly-Omic Prediction of Complex Traits: OmicKriging. GENET EPIDEMIOL 2014;38 (5):402-415 [PubMed]
Wu K, Gamazon ER, Im HK, Geeleher P, White SR, Solway J, Clemmer GL, Weiss ST, Tantisira KG, Cox NJ, Ratain MJ, Huang RS, Genome-wide Interrogation of Longitudinal FEV1 in Children with Asthma. AM J RESP CRIT CARE 2014;190 (6):619-627 [PubMed]
Zhang X, Moen EL, Liu C, Mu W, Gamazon ER, Delaney SM, Wing C, Godley LA, Dolan ME, Zhang W, Linking the genetic architecture of cytosine modifications with human complex traits. HUM MOL GENET 2014;23 (22):5893-5905 [PubMed]
Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SMJ, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HGM, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM, Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture. PLOS GENET 2013;9 (10):e1003864 [PubMed]
Gamazon ER, Badner JA, Cheng L, Zhang C, Zhang D, Cox NJ, Gershon ES, Kelsoe JR, Greenwood TA, Nievergelt CM, Chen C, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI, Edenberg HJ, Foroud T, Koller DL, Scheftner WA, Coryell W, Rice J, Lawson WB, Nwulia EA, Hipolito M, Byerley W, McMahon FJ, Schulze TG, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Liu C, Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. MOL PSYCHIATR 2013;18 (3):340-346 [PubMed]
Gamazon ER, Huang RS, Cox NJ, SCAN: a systems biology approach to pharmacogenomic discovery. METHODS MOL BIOL 2013;1015:213-224 [PubMed]
Gamazon ER, Innocenti F, Wei R, Wang L, Zhang M, Mirkov S, Ramírez J, Huang RS, Cox NJ, Ratain MJ, Liu W, A genome-wide integrative study of microRNAs in human liver. BMC GENOMICS 2013;14:395 [PubMed]
Gamazon ER, Lamba JK, Pounds S, Stark AL, Wheeler HE, Cao X, Im HK, Mitra AK, Rubnitz JE, Ribeiro RC, Raimondi S, Campana D, Crews KR, Wong SS, Welsh M, Hulur I, Gorsic L, Hartford CM, Zhang W, Cox NJ, Dolan ME, Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients. BLOOD 2013;121 (21):4366-4376 [PubMed]
Gamazon ER, Pinto N, Konkashbaev A, Im HK, Diskin SJ, London WB, Maris JM, Dolan ME, Cox NJ, Cohn SL, Trans-population Analysis of Genetic Mechanisms of Ethnic Disparities in Neuroblastoma Survival. JNCI-J NATL CANCER I 2013;105 (4):302-309 [PubMed]
Huang RS, Gamazon ER, Translating pharmacogenomics discoveries into the clinic: an implementation framework. GENOME MED 2013;5 (10):94 [PubMed]
Lee Y, Li H, Li J, Rebman E, Achour I, Regan KE, Gamazon ER, Chen JL, Yang XH, Cox NJ, Lussier YA, Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases. J AM MED INFORM ASSN 2013;20 (4):619-629 [PubMed]
Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AHB, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA, Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. LANCET 2013;382 (9894):790-796 [PubMed]
Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL [Contributors: Arepalli S, Cookson MR, Dillman A, Ferrucci L, Gibbs JR, Hernandez DG, Johnson R, Longo DL, Nalls MA, O'Brien R, Singleton A, Traynor B, Troncoso J, van der Brug M, Zielke HR, Zonderman A, Hardy JA, Ryten M, Smith C, Trabzuni D, Walker R, Weale M]] , Genome-wide association study of Tourette's syndrome. MOL PSYCHIATR 2013;18 (6):721-728 [PubMed]
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH Jr, Kennedy JL, Rosenberg D, Stein DJ, Hemmings SMJ, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy DL, Wendland JR, Veenstra-Vanderweele J, Denys D, Blom R, Deforce D, van Nieuwerburgh F, Westenberg HGM, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Conceição do Rosário M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A, Arepalli S, Dillman A, Ferrucci L, Hernandez DG, Johnson R, Longo DL, Nalls MA, O Brien R, Traynor B, Troncoso J, van der Brug M, Zielke HR, Zonderman A, Hardy J, Hardy JA, Ryten M, Smith C, Trabzuni D, Walker R, Weale M, Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL, Genome-wide association study of obsessive-compulsive disorder. MOL PSYCHIATR 2013;18 (7):788-798 [PubMed]
Weng L, Ziliak D, Im HK, Gamazon ER, Philips S, Nguyen AT, Desta Z, Skaar TC, Flockhart DA, Huang RS, Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation. ANN ONCOL 2013;24 (7):1867-1873 [PubMed]
Wheeler HE, Gamazon ER, Stark AL, O'Donnell PH, Gorsic LK, Huang RS, Cox NJ, Dolan ME, Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. PHARMACOGENOMICS J 2013;13 (1):35-43 [PubMed]
Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer EP, Hudis CA, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Cox NJ, Dolan ME, Integration of Cell Line and Clinical Trial Genome-Wide Analyses Supports a Polygenic Architecture of Paclitaxel-Induced Sensory Peripheral Neuropathy. CLIN CANCER RES 2013;19 (2):491-499 [PubMed]
Zheng Y, Ogundiran TO, Falusi AG, Nathanson KL, John EM, Hennis AJM, Ambs S, Domchek SM, Rebbeck TR, Simon MS, Nemesure B, Wu SY, Leske MC, Odetunde A, Niu Q, Zhang J, Afolabi C, Gamazon ER, Cox NJ, Olopade CO, Olopade OI, Huo D, Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers. CARCINOGENESIS 2013;34 (7):1520-1528 [PubMed]
[Contributors: Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N, Foster B, Moser M, Karasik E, Gillard B, Ramsey K, Sullivan S, Bridge J, Magazine H, Syron J, Fleming J, Siminoff L, Traino H, Mosavel M, Barker L, Jewell S, Rohrer D, Maxim D, Filkins D, Harbach P, Cortadillo E, Berghuis B, Turner L, Hudson E, Feenstra K, Sobin L, Robb J, Branton P, Korzeniewski G, Shive C, Tabor D, Qi L, Groch K, Nampally S, Buia S, Zimmerman A, Smith A, Burges R, Robinson K, Valentino K, Bradbury D, Cosentino M, Diaz-Mayoral N, Kennedy M, Engel T, Williams P, Erickson K, Ardlie K, Winckler W, Getz G, DeLuca D, MacArthur D, Kellis M, Thomson A, Young T, Gelfand E, Donovan M, Grant G, Mash D, Marcus Y, Basile M, Liu J, Zhu J, Tu Z, Cox NJ, Nicolae DL, Gamazon ER, Kyung H, Konkashbaev A, Pritchard J, Stevens M, Flutre T, Wen X, Dermitzakis T, Lappalainen T, Guigo R, Monlong J, Sammeth M, Koller D, Battle A, Mostafavi S, McCarthy M, Rivas M, Maller J, Rusyn I, Nobel A, Wright F, Shabalin A, Feolo M, Sharopova N, Sturcke A, Paschal J, Anderson JM, Wilder EL, Derr LK, Green ED, Struewing JP, Temple G, Volpi S, Boyer JT, Thomson EJ, Guyer MS, Ng C, Abdallah A, Colantuoni D, Insel TR, Koester SE, Little AR, Bender PK, Lehner T, Yao Y, Compton CC, Vaught JB, Sawyer S, Lockhart NC, Demchok J, Moore HF]] , The Genotype-Tissue Expression (GTEx) project. NAT GENET 2013;45 (6):580-585 [PubMed]
Chen LS, Hsu L, Gamazon ER, Cox NJ, Nicolae DL, An Exponential Combination Procedure for Set-Based Association Tests in Sequencing Studies. AM J HUM GENET 2012;91 (6):977-986 [PubMed]
Cox NJ, Gamazon ER, Wheeler HE, Dolan ME, Clinical Translation of Cell-Based Pharmacogenomic Discovery. CLIN PHARMACOL THER 2012;92 (4):425-427 [PubMed]
Davis LK, Gamazon ER, Kistner-Griffin E, Badner JA, Liu C, Cook EH, Sutcliffe JS, Cox NJ, Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci. MOL AUTISM 2012;3 (1):3 [PubMed]
Elbein SC, Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ, Genetic Risk Factors for Type 2 Diabetes: A Trans-Regulatory Genetic Architecture?. AM J HUM GENET 2012;91 (3):466-477 [PubMed]
Gamazon ER, Small Science: High Stakes. SCIENCE 2012;338 (6109):883 [PubMed]
Gamazon ER, Huang RS, Dolan ME, Cox NJ, Im HK, Integrative genomics: quantifying significance of phenotype-genotype relationships from multiple sources of high-throughput data. FRONT GENET 2012;3:202 [PubMed]
Gamazon ER, Perera M, Genome-wide approaches in pharmacogenomics: heritability estimation and pharmacoethnicity as primary challenges. PHARMACOGENOMICS 2012;13 (10):1101-1104 [PubMed]
Gamazon ER, Skol AD, Perera MA, The limits of genome-wide methods for pharmacogenomic testing. PHARMACOGENET GENOM 2012;22 (4):261-272 [PubMed]
Gamazon ER, Ziliak D, Im HK, LaCroix B, Park DS, Cox NJ, Huang RS, Genetic Architecture of MicroRNA Expression: Implications for the Transcriptome and Complex Traits. AM J HUM GENET 2012;90 (6):1046-1063 [PubMed]
Geeleher P, Huang SR, Gamazon ER, Golden A, Seoighe C, The regulatory effect of miRNAs is a heritable genetic trait in humans. BMC GENOMICS 2012;13:383 [PubMed]
Hou N, Zheng Y, Gamazon ER, Ogundiran TO, Adebamowo C, Nathanson KL, Domchek SM, Rebbeck TR, Simon MS, John EM, Hennis A, Nemesure B, Wu SY, Leske MC, Ambs S, Niu Q, Zhang J, Pierce B, Cox NJ, Olopade OI, Huo D, Genetic Susceptibility to Type 2 Diabetes and Breast Cancer Risk in Women of European and African Ancestry. CANCER EPIDEM BIOMAR 2012;21 (3):552-556 [PubMed]
Im HK, Gamazon ER, Nicolae DL, Cox NJ, On Sharing Quantitative Trait GWAS Results in an Era of Multiple-omics Data and the Limits of Genomic Privacy. AM J HUM GENET 2012;90 (4):591-598 [PubMed]
Im HK, Gamazon ER, Stark AL, Huang RS, Cox NJ, Dolan ME, Mixed Effects Modeling of Proliferation Rates in Cell-Based Models: Consequence for Pharmacogenomics and Cancer. PLOS GENET 2012;8 (2):e1002525 [PubMed]
Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI, Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. P NATL ACAD SCI USA 2012;109 (35):E2343-E2352 [PubMed]
Lee Y, Gamazon ER, Rebman E, Lee Y, Lee S, Dolan ME, Cox NJ, Lussier YA, Variants Affecting Exon Skipping Contribute to Complex Traits. PLOS GENET 2012;8 (10):e1002998 [PubMed]
Lertpiriyapong K, Gamazon ER, Feng Y, Park DS, Pang J, Botka G, Graffam ME, Ge Z, Fox JG, Campylobacter jejuni Type VI Secretion System: Roles in Adaptation to Deoxycholic Acid, Host Cell Adherence, Invasion, and In Vivo Colonization. PLOS ONE 2012;7 (8):e42842 [PubMed]
Njiaju UO, Gamazon ER, Gorsic LK, Delaney SM, Wheeler HE, Im HK, Dolan ME, Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel. PHARMACOGENET GENOM 2012;22 (7):498-507 [PubMed]
O'Donnell PH, Stark AL, Gamazon ER, Wheeler HE, McIlwee BE, Gorsic L, Im HK, Huang RS, Cox NJ, Dolan ME, Identification of novel germline polymorphisms governing capecitabine sensitivity. CANCER-AM CANCER SOC 2012;118 (16):4063-4073 [PubMed]
Wen Y, Gamazon ER, Bleibel WK, Wing C, Mi S, McIlwee BE, Delaney SM, Duan S, Im HK, Dolan ME, An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. HUM MOL GENET 2012;21 (7):1470-1480 [PubMed]
Ziliak D, Gamazon ER, LaCroix B, Kyung Im H, Wen Y, Huang RS, Genetic Variation That Predicts Platinum Sensitivity Reveals the Role of miR-193b* in Chemotherapeutic Susceptibility. MOL CANCER THER 2012;11 (9):2054-2061 [PubMed]
Below JE, Gamazon ER, Morrison JV, Konkashbaev A, Pluzhnikov A, McKeigue PM, Parra EJ, Elbein SC, Hallman DM, Nicolae DL, Bell GI, Cruz M, Cox NJ, Hanis CL, Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. DIABETOLOGIA 2011;54 (8):2047-2055 [PubMed]
Gamazon ER, Huang RS, Dolan ME, Cox NJ, Copy number polymorphisms and anticancer pharmacogenomics. GENOME BIOL 2011;12 (5):R46 [PubMed]
Gamazon ER, Im HK, O'Donnell PH, Ziliak D, Stark AL, Cox NJ, Dolan ME, Huang RS, Comprehensive Evaluation of the Contribution of X Chromosome Genes to Platinum Sensitivity. MOL CANCER THER 2011;10 (3):472-480 [PubMed]
Gamazon ER, Nicolae DL, Cox NJ, A Study of CNVs As Trait-Associated Polymorphisms and As Expression Quantitative Trait Loci. PLOS GENET 2011;7 (2):e1001292 [PubMed]
Huang RS, Gamazon ER, Ziliak D, Wen Y, Im HK, Zhang W, Wing C, Duan S, Bleibel WK, Cox NJ, Dolan ME, Population differences in microRNA expression and biological implications. RNA BIOL 2011;8 (4):692-701 [PubMed]
Huang RS, Johnatty SE, Gamazon ER, Im HK, Ziliak D, Duan S, Zhang W, Kistner EO, Chen P, Beesley J, Mi S, O'Donnell PH, Fraiman YS, Das S, Cox NJ, Lu Y, Macgregor S, Goode EL, Vierkant RA, Fridley BL, Hogdall E, Kjaer SK, Jensen A, Moysich KB, Grasela M, Odunsi K, Brown R, Paul J, Lambrechts D, Despierre E, Vergote I, Gross J, Karlan BY, Defazio A, Chenevix-Trench G, Dolan ME, Platinum Sensitivity-Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients. CLIN CANCER RES 2011;17 (16):5490-5500 [PubMed]
Innocenti F, Cooper GM, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, Ramirez J, Liu W, Lin YS, Moloney C, Aldred SF, Trinklein ND, Schuetz E, Nickerson DA, Thummel KE, Rieder MJ, Rettie AE, Ratain MJ, Cox NJ, Brown CD, Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue. PLOS GENET 2011;7 (5):e1002078 [PubMed]
Perera MA, Gamazon E, Cavallari LH, Patel SR, Poindexter S, Kittles RA, Nicolae D, Cox NJ, The Missing Association: Sequencing-Based Discovery of Novel SNPs in VKORC1 and CYP2C9 That Affect Warfarin Dose in African Americans. CLIN PHARMACOL THER 2011;89 (3):408-415 [PubMed]
Wheeler HE, Gorsic LK, Welsh M, Stark AL, Gamazon ER, Cox NJ, Dolan ME, Genome-Wide Local Ancestry Approach Identifies Genes and Variants Associated with Chemotherapeutic Susceptibility in African Americans. PLOS ONE 2011;6 (7):e21920 [PubMed]
Ziliak D, O'Donnell PH, Im HK, Gamazon ER, Chen P, Delaney S, Shukla S, Das S, Cox NJ, Vokes EE, Cohen EEW, Dolan ME, Huang RS, Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers. TRANSL RES 2011;157 (5):265-272 [PubMed]
Gamazon ER, Duan S, Zhang W, Huang RS, Kistner EO, Dolan ME, Cox NJ, PACdb: a database for cell-based pharmacogenomics. PHARMACOGENET GENOM 2010;20 (4):269-273 [PubMed]
Gamazon ER, Huang RS, Cox NJ, Dolan ME, Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci. P NATL ACAD SCI USA 2010;107 (20):9287-9292 [PubMed]
Gamazon ER, Im HK, Duan S, Lussier YA, Cox NJ, Dolan ME, Zhang W, ExprTarget: An Integrative Approach to Predicting Human MicroRNA Targets. PLOS ONE 2010;5 (10):e13534 [PubMed]
Gamazon ER, Zhang W, Dolan ME, Cox NJ, Comprehensive Survey of SNPs in the Affymetrix Exon Array Using the 1000 Genomes Dataset. PLOS ONE 2010;5 (2):e9366 [PubMed]
Gamazon ER, Zhang W, Konkashbaev A, Duan S, Kistner EO, Nicolae DL, Dolan ME, Cox NJ, SCAN: SNP and copy number annotation. BIOINFORMATICS 2010;26 (2):259-262 [PubMed]
Lee Y, Li J, Gamazon E, Chen JL, Tikhomirov A, Cox NJ, Lussier YA, Biomolecular Systems of Disease Buried Across Multiple GWAS Unveiled by Information Theory and Ontology. AMIA JT SUMMITS TRANSL SCI PROC 2010;2010:31-35 [PubMed]
Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ, Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS. PLOS GENET 2010;6 (4):e1000888 [PubMed]
O'Donnell PH, Gamazon E, Zhang W, Stark AL, Kistner-Griffin EO, Stephanie Huang R, Eileen Dolan M, Population differences in platinum toxicity as a means to identify novel genetic susceptibility variants. PHARMACOGENET GENOM 2010;20 (5):327-337 [PubMed]
Gamazon ER, Zhang W, Huang RS, Dolan ME, Cox NJ, A pharmacogene database enhanced by the 1000 Genomes Project. PHARMACOGENET GENOM 2009;19 (10):829-832 [PubMed]
Key publications

Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, Nicolae DL, Cox NJ, Im HK, A gene-based association method for mapping traits using reference transcriptome data. NAT GENET 2015;47 (9):1091-+ [PubMed]
Gamazon ER, Cox NJ, Davis LK, Structural Architecture of SNP Effects on Complex Traits. AM J HUM GENET 2014;95 (5):477-489 [PubMed]
Gamazon ER, Ziliak D, Im HK, LaCroix B, Park DS, Cox NJ, Huang RS, Genetic Architecture of MicroRNA Expression: Implications for the Transcriptome and Complex Traits. AM J HUM GENET 2012;90 (6):1046-1063 [PubMed]
Gamazon ER, Badner JA, Cheng L, Zhang C, Zhang D, Cox NJ, Gershon ES, Kelsoe JR, Greenwood TA, Nievergelt CM, Chen C, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI, Edenberg HJ, Foroud T, Koller DL, Scheftner WA, Coryell W, Rice J, Lawson WB, Nwulia EA, Hipolito M, Byerley W, McMahon FJ, Schulze TG, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Liu C, Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. MOL PSYCHIATR 2013;18 (3):340-346 [PubMed]
Gamazon ER, Pinto N, Konkashbaev A, Im HK, Diskin SJ, London WB, Maris JM, Dolan ME, Cox NJ, Cohn SL, Trans-population Analysis of Genetic Mechanisms of Ethnic Disparities in Neuroblastoma Survival. JNCI-J NATL CANCER I 2013;105 (4):302-309 [PubMed]


All Publications

Curriculum Vitae

Eric R. Gamazon, M.S., Ph.D.

Affiliation

Academic Medical Center, University of Amsterdam (Psychiatrie: Volwassenenpsychiatrie; Klinische Epidemiologie, Biostatistiek en Bioinformatica), Amsterdam, The Netherlands

Publications

https://www.amc.nl/web/Research/Who-is-Who-in-Research/Who-is-Who-in-Research.htm?p=6583&v=publications

Consortia and Research Groups

  1. Genotype-Tissue Expression (GTEx) Consortium (2012 – Present).
  2. Type 2 Diabetes (T2D) Genetic Exploration by Next-generation Sequencing in Ethnic Samples (T2D-GENES) Consortium (2012 – present).
  3. International Warfarin Pharmacogenetics Consortium – Genome Wide Association Studies (IWPC-GWAS).
  4. Pharmacogenomics of Anticancer Agents Research (PAAR) Group: Genetics and Informatics Using Statistics (GENIUS) Core

Select Activities

  1. Gene-based method paper (Gamazon et al, Nature Genetics, 2015) selected one of the top three papers in the category of “Methods for Genetic Discovery” in the AMIA “Translational Bioinformatics 2016: The Year in Review“.
  2. Robert C. Elston Award Best Paper Award from the International Genetic Epidemiology Society.
  3. Co-chair GWAS Working Subgroup of GTEx Consortium. Phase 1 paper selected to be on the front cover of Science.
  4. Research on the gene IRX3 and obesity (Nature, 2014) selected as one of top advances in functional genomics and translational biology for 2014 (American Heart Association Functional Genomics and Translational Biology Council).
  5. Alice W. Chandler Recognition 2014 honoree, The University of Chicago
  6. Gamazon et al, Journal of the National Cancer Institute (2013) selected in the annual assessment (“Clinical Cancer Advances 2013”) by the American Society of Clinical Oncology (ASCO) as one of “the advances in cancer research with the greatest potential to improve patient care and quality of life”.
  7. Genotype-Tissue Expression (GTEx) Project Community Meeting at the Broad Institute of MIT and Harvard (Cambridge, MA, 2013): “GTEx: Expanding on Genome-Wide Association Studies”.
  8. PGRN Statistical Analysis Resource (P-STAR) Workshop (Austin, TX, 2012): “The Convergence of Functional Genomics, Heritability Estimation and Polygenic Modeling”.
  9. Research featured in Genome Technology April 2012 issue highlighting advances in cancer research from previous year.
  10. Affymetrix PanAsia Genome-wide Association Studies (Shanghai, China, 2011): “SCAN: Extending Genome-wide Association Studies”
  11. Platform presentation at American Society of Human Genetics (ASHG) Annual Meeting (Washington D.C., 2010). “Mapping genes near Type 2 Diabetes (T2D) Associated Loci as Expression Quantitative Trait Loci (eQTL) in Human Adipose and Muscle”

 

Research programmes
Other research related activities
  • None reported
Current research funding
  • None reported