Laboratory of Experimental Intensive Care and Anesthesiology (LEICA)

The Laboratory of Experimental Intensive Care and Anesthesiology (LEICA) of the Academic Medical Center (AMC), University of Amsterdam, is the first laboratory in the Netherlands and almost unique in Europe consisting of a common research platform to address basic science questions in Intensive Care and Anesthesiology.

The idea to strengthen, focus and condense research interests of both disciplines was generated in 2005 by the Chairs of L.E.I.C.A., prof. dr. dr. Markus W. Hollmann, DEAA (Anesthesiology) and prof.dr. Marcus J. Schultz (Intensive Care).

The main focus of research concentrates on cardio–protection, mechanical ventilation and pharmacology of local anesthetics. Pathophysiologic mechanisms of and protective strategies against ischemia–reperfusion injury in the heart, influences of metabolic and inflammatory processes on myocardial and vascular physiology, “alternative” effects of local anesthetics, lung–protective ventilation strategies in various pulmonary diseases (acute lung injury (ALI), acute respiratory distress syndrome (ARDS), transfusion–related lung injury (TRALI) and pneumonia), effects of mechanical ventilation on coagulation, inflammation and renal function employing various physiologic, pharmacologic, electrophysiologic and molecular biology techniques are addressed (see current research).

Following several years, during which L.E.I.C.A.–researchers had to share laboratory space with the Department of Physiology, we are proud to have our own, from October 2006 – March 2007 rebuild, fully–equipped laboratory. The whole laboratory consists of eleven officially accredited labs with an overall lab space of 150 qm.

One Professor, two Associate Professors , four Assistant Professors, ten PhD–students (9 physicians, enrolled in a MD (resident) – PhD program, and 1 biologist) and on average five students (medical and natural sciences) belong to the L.E.I.C.A.–research group.


Meibergdreef 15
Location M0-128
1105 AZ Amsterdam
The Netherlands
tel.: +31 (0)20 56 62533
fax: +31 (0)20 69 79441

Mail Nina Hauck-Weber
Tel. +31 (0)20 56 68215