Pediatric nephrology

Research lines pediatric nephrology department:

  1. End-stage renal disease in children
    This clinical research line is focused on the improvement of the quality of care of chronic renal replacement therapy (RRT) in children. The aim is to describe current somatic and psychosocial outcomes of ESRD children and evaluate new more optimal strategies and monitoring tools of quality of care of chronic renal replacement therapy in children. There is a close collaboration with the KIK ( ESPN registry), the department of Psychosocial Research in Pediatrics and the department of Pediatric cardiology (monitoring of cardiovascular disease). There is also a close collaboration with all Dutch and Belgian centers for chronic renal replacement therapy as well as the German centers of Bonn and Cologne of RRT in children.
  2. Primary Hyperoxaluria
    The Ped Nephrology department is expertise center of this rare disease. Focus of the research part is the unraveling of the specific metabolic pathways leading to hyperoxaluria and participation in international trials for patients with Primary Hyperoxaluria type 1. There is a close collaboration with the Department of Metabolic disease.
  3. Nephrotic syndrome
    Focus is on new therapies for idiopathic nephrotic syndrome. (INS) The current application is the follow-up of an international RCT to the efficacy of levamisole in INS.
  4. LDL-apheresis in homozygous familiar hypercholesterolemia
    The AMC is expertise center for lipid abnormalities and the department of Pediatric Nephrology is the only center in the NL that provides LDL-apheresis in children with homozygous Familiar hypercholesterolemia, a rare form of extreme high LDL-cholesterol levels with early onset of atherosclerosis. The research focuses on the world wide epidemiology of LDL-A in homozygous FH.