• Principal Investigator
  • Male

Prof. dr. F.G.J. Cobelens MD MSc PhD

Position: Professor
Main activities: Research, Teaching
Specialisation: Global Health
foto F.G.J. Cobelens is one of the AMC Principal Investigators
Focus of research:

Epidemiology and control of poverty-related infectious diseases, in particular tuberculosis

AMC themes: Infection & Immunity, Public Health & Epidemiology
Departments: Global Health
Alffenaar JWC, Akkerman OW, Anthony RM, Tiberi S, Heysell S, Grobusch MP, Cobelens FG, van Soolingen D, Individualizing management of extensively drug-resistant tuberculosis: diagnostics, treatment, and biomarkers. EXPERT REV ANTI-INFE 2017;15 (1):11-21 [PubMed]
Boere TM, Visser DH, van Furth AM, Lips P, Cobelens FGJ, Solar ultraviolet B exposure and global variation in tuberculosis incidence: an ecological analysis. EUR RESPIR J 2017;49 (6):1601979 [PubMed]
Chanda-Kapata P, Kapata N, Klinkenberg E, Grobusch MP, Cobelens F, The prevalence of HIV among adults with pulmonary TB at a population level in Zambia. BMC INFECT DIS 2017;17 (1):236 [PubMed]
Cobelens F, Apples, oranges and chest X-rays. INT J TUBERC LUNG D 2017;21 (4):472 [PubMed]
Cobelens F, Kik S, Esmail H, Cirillo DM, Lienhardt C, Matteelli A, From latent to patent: rethinking prediction of tuberculosis. LANCET RESP MED 2017;5 (4):243-244 [PubMed]
Cox H, Dickson-Hall L, Ndjeka N, van't Hoog A, Grant A, Cobelens F, Stevens W, Nicol M, Delays and loss to follow-up before treatment of drug-resistant tuberculosis following implementation of Xpert MTB/RIF in South Africa: A retrospective cohort study. PLOS MED 2017;14 (2):e1002238 [PubMed]
Erkens C. Evaluating the effectiveness of interventions for the prevention of tuberculosis in a low-incidence setting. S.l.: s.n.; 2017. 146p. ISBN 978-94-91602-93-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Cobelens FGJ; copromotor(s): van den Hof S)
Fofana MO, Shrestha S, Knight GM, Cohen T, White RG, Cobelens F, Dowdy DW, A Multistrain Mathematical Model To Investigate the Role of Pyrazinamide in the Emergence of Extensively Drug-Resistant Tuberculosis. ANTIMICROB AGENTS CH 2017;61 (3):e00498-16 [PubMed]
García-Basteiro AL, Mambuque E, den Hertog A, Saavedra B, Cuamba I, Oliveras L, Blanco S, Bulo H, Brew J, Cuevas LE, Cobelens F, Nhabomba A, Anthony R, IP-10 Kinetics in the First Week of Therapy are Strongly Associated with Bacteriological Confirmation of Tuberculosis Diagnosis in HIV-Infected Patients. SCI REP-UK 2017;7 (1):14302 [PubMed]
García-Basteiro AL, Miranda Ribeiro R, Brew J, Sacoor C, Valencia S, Bulo H, Cobelens F, Macete E, Tuberculosis on the rise in southern Mozambique (1997-2012). EUR RESPIR J 2017;49 (3):1601683 [PubMed]
García-Basteiro AL, Saavedra B, Cobelens F, The Good, the Bad and the Ugly of the Next-Generation Xpert Mtb/Rif(®) Ultra Test for Tuberculosis Diagnosis. ARCH BRONCONEUMOL 2017;ahead of print [PubMed]
Kapata N, Grobusch MP, Chongwe G, Chanda-Kapata P, Ngosa W, Tembo M, Musonda S, Katemangwe P, Bates M, Mwaba P, Zumla A, Cobelens F, Outcomes of multidrug-resistant tuberculosis in Zambia: a cohort analysis. INFECTION 2017;ahead of print [PubMed]
Kendall EA, Azman AS, Cobelens FG, Dowdy DW, MDR-TB treatment as prevention: The projected population-level impact of expanded treatment for multidrug-resistant tuberculosis. PLOS ONE 2017;12 (3):e0172748 [PubMed]
Mandalakas AM, Cobelens F, Tuberculosis-making predictions, especially about the future. LANCET INFECT DIS 2017;17 (11):1106-1107 [PubMed]
Miranda P, Gil-Santana L, Oliveira MG, Mesquita EDD, Silva E, Rauwerdink A, Cobelens F, Oliveira MM, Andrade BB, Kritski A, Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation. PLOS ONE 2017;12 (4):e0175278 [PubMed]
Ssengooba W. Consequences of Mycobacterium tuberculosis genetic diversity in the context of HIV co-infection for laboratory diagnosis of tuberculosis in Africa. S.l.: s.n.; 2017. 191p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Cobelens FGJ; copromotor(s): Vila J, van Leth FCM, Mandomando I, de Jong BCH)
Ssengooba W, Lukoye D, Meehan CJ, Kateete DP, Joloba ML, de Jong BC, Cobelens FG, van Leth F, Tuberculosis resistance-conferring mutations with fitness cost among HIV-positive individuals in Uganda. INT J TUBERC LUNG D 2017;21 (5):531-536 [PubMed]
Trajman A, Cobelens F, It takes more than a sensitive test to find more tuberculosis cases. LANCET INFECT DIS 2017;17 (4):357-358 [PubMed]
Chanda-Kapata P, Kapata N, Masiye F, Maboshe M, Klinkenberg E, Cobelens F, Grobusch MP, Health Seeking Behaviour among Individuals with Presumptive Tuberculosis in Zambia. PLOS ONE 2016;11 (10):e0163975 [PubMed]
Cobelens F, Gebhard A, van den Hof S, No evidence that pyrazinamide resistance is acquired after fluoroquinolone resistance. INT J TUBERC LUNG D 2016;20 (2):282 [PubMed]
Domínguez J, Boettger EC, Cirillo D, Cobelens F, Eisenach KD, Gagneux S, Hillemann D, Horsburgh R, Molina-Moya B, Niemann S, Tortoli E, Whitelaw A, Lange C, Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a TBNET/RESIST-TB consensus statement. INT J TUBERC LUNG D 2016;20 (1):24-U61 [PubMed]
Erkens CGM, Slump E, Verhagen M, Schimmel H, Cobelens F, van den Hof S, Risk of developing tuberculosis disease among persons diagnosed with latent tuberculosis infection in the Netherlands. EUR RESPIR J 2016;48 (5):1420-1428 [PubMed]
Erkens CGM, Slump E, Verhagen M, Schimmel H, de Vries G, Cobelens F, van den Hof S, Monitoring latent tuberculosis infection diagnosis and management in the Netherlands. EUR RESPIR J 2016;47 (5):1492-1501 [PubMed]
Fox GJ, Benedetti A, Mitnick CD, Pai M, Menzies D [Contributors: Ahuja S, Ashkin D, Avendaño M, Banerjee R, Bauer M, Becerra M, Burgos M, Centis R, Chan ED, Chiang CY, Cobelens F, Cox H, D'Ambrosio L, de Lange WCM, DeRiemer K, Enarson D, Falzon D, Flanagan K, Flood J, Gandhi N, Garcia-Garcia L, Granich RM, Hollm-Delgado MG, Holtz TH, Hopewell P, Iseman M, Jarlsberg LG, Keshavjee S, Kim HR, Lancaster J, Lange C, Leimane V, Leung CC, Koh WJ, Li J, Menzies D, Migliori GB, Narita M, Nathanson E, Odendaal R, O'Riordan P, Pai M, Palmero D, Park SK, Pasvol G, Pena J, Pérez-Guzmán C, Ponce-de-Leon A, Quelapio MID, Quy HT, Riekstina V, Robert J, Royce S, Salim M, Schaaf HS, Seung KJ, Shah L, Shean K, Shim TS, Shin SS, Shiraishi Y, Sifuentes-Osornio J, Sotgiu G, Strand MJ, Sung SW, Tabarsi P, Tupasi TE, Vargas MH, van Altena R, Viiklepp P, van der Walt M, van der Werf TS, Westenhouse J, Yew WW, Yim JJ]] , Propensity Score-Based Approaches to Confounding by Indication in Individual Patient Data Meta-Analysis: Non-Standardized Treatment for Multidrug Resistant Tuberculosis. PLOS ONE 2016;11 (3):e0151724 [PubMed]
García-Basteiro AL, Respeito D, Augusto OJ, López-Varela E, Sacoor C, Sequera VG, Casellas A, Bassat Q, Manhiça I, Macete E, Cobelens F, Alonso PL, Erratum to: Poor tuberculosis treatment outcomes in Southern Mozambique (2011-2012). BMC INFECT DIS 2016;16 (1):603 [PubMed]
García-Basteiro AL, Respeito D, Augusto OJ, López-Varela E, Sacoor C, Sequera VG, Casellas A, Bassat Q, Manhiça I, Macete E, Cobelens F, Alonso PL, Poor tuberculosis treatment outcomes in Southern Mozambique (2011-2012). BMC INFECT DIS 2016;16 (1):214 [PubMed]
Gomez GB, Dowdy DW, Bastos ML, Zwerling A, Sweeney S, Foster N, Trajman A, Islam MA, Kapiga S, Sinanovic E, Knight GM, White RG, Wells WA, Cobelens FG, Vassall A, Cost and cost-effectiveness of tuberculosis treatment shortening: a model-based analysis. BMC INFECT DIS 2016;16 (1):726 [PubMed]
Gray CM, Katamba A, Narang P, Giraldo J, Zamudio C, Joloba M, Narang R, Paramasivan CN, Hillemann D, Nabeta P, Amisano D, Alland D, Cobelens F, Boehme CC, Feasibility and Operational Performance of Tuberculosis Detection by Loop-Mediated Isothermal Amplification Platform in Decentralized Settings: Results from a Multicenter Study. J CLIN MICROBIOL 2016;54 (8):1984-1991 [PubMed]
Head MG. Research investments in global infectious diseases - a systematic analysis of the UK research portfolio. S.l.: s.n.; 2016. 100p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij University College London, Research Department of Infection and PopulationHealth. (Promotor(s): Cobelens FGJ; copromotor(s): Atun R, Gomez Guillen G)
Hoang TTT. An analysis of multi drug resistant tuberculosis control in Vietnam. S.l.: s.n.; 2016. -p. Proefschrift Open University UK, -. (Promotor(s): Thwaites G; copromotor(s): Wertheim HFL, Cobelens FGJ)
Kerkhoff AD. Anaemia in patients with HIV-associated tuberculosis in South Africa: predictive/prognostic value, aetiologies and treatment. S.l.: s.n.; 2016. 166p. ISBN 978-94-028-0125-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Cobelens FGJ, Lawn SD; copromotor(s): )
Kik SV, Cobelens F, Moore D, Predicting tuberculosis risk. LANCET 2016;388 (10057):2233-2234 [PubMed]
Kunkel A, Cobelens FG, Cohen T, Tradeoffs in Introduction Policies for the Anti-Tuberculosis Drug Bedaquiline: A Model-Based Analysis. PLOS MED 2016;13 (10):e1002142 [PubMed]
Lienhardt C, Lönnroth K, Menzies D, Balasegaram M, Chakaya J, Cobelens F, Cohn J, Denkinger CM, Evans TG, Källenius G, Kaplan G, Kumar AMV, Matthiessen L, Mgone CS, Mizrahi V, Mukadi YD, Nguyen VN, Nordström A, Sizemore CF, Spigelman M, Squire SB, Swaminathan S, van Helden PD, Zumla A, Weyer K, Weil D, Raviglione M, Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions. PLOS MED 2016;13 (3):e1001965 [PubMed]
Manabe YC, Worodria W, van Leth F, Mayanja-Kizza H, Traore AN, Ferro J, Pakker N, Frank M, Grobusch MP, Colebunders R, Cobelens F, Prevention of Early Mortality by Presumptive Tuberculosis Therapy Study: An Open Label, Randomized Controlled Trial. AM J TROP MED HYG 2016;95 (6):1265-1271 [PubMed]
Mitnick CD, Rodriguez CA, Hatton ML, Brigden G, Cobelens F, Grobusch MP, Horsburgh R, Lange C, Lienhardt C, Oren E, Podewils LJ, Seaworth B, van den Hof S, Daley CL, Gebhard AC, Wares F, Programmatic Management of Drug-Resistant Tuberculosis: An Updated Research Agenda. PLOS ONE 2016;11 (5):e0155968 [PubMed]
Pinto M, Steffen RE, Cobelens F, van den Hof S, Entringer A, Trajman A, Cost-effectiveness of the Xpert® MTB/RIF assay for tuberculosis diagnosis in Brazil. INT J TUBERC LUNG D 2016;20 (5):611-618 [PubMed]
Ssengooba W, de Jong BC, Joloba ML, Cobelens FG, Meehan CJ, Whole genome sequencing reveals mycobacterial microevolution among concurrent isolates from sputum and blood in HIV infected TB patients. BMC INFECT DIS 2016;16 (1):371 [PubMed]
Ssengooba W, Meehan CJ, Lukoye D, Kasule GW, Musisi K, Joloba ML, Cobelens FG, de Jong BC, Whole genome sequencing to complement tuberculosis drug resistance surveys in Uganda. INFECT GENET EVOL 2016;40:8-16 [PubMed]
Ssengooba W, Respeito D, Mambuque E, Blanco S, Bulo H, Mandomando I, de Jong BC, Cobelens FG, García-Basteiro AL, Do Xpert MTB/RIF Cycle Threshold Values Provide Information about Patient Delays for Tuberculosis Diagnosis?. PLOS ONE 2016;11 (9):e0162833 [PubMed]
Trajman A, Bastos ML, Belo M, Calaça J, Gaspar J, Dos Santos AM, Dos Santos CM, Brito RT, Wells WA, Cobelens FG, Vassall A, Gomez GB, Shortened first-line TB treatment in Brazil: potential cost savings for patients and health services. BMC HEALTH SERV RES 2016;16 (1):27 [PubMed]
van der Burgt EPM, Sturkenboom MGG, Bolhuis MS, Akkerman OW, Kosterink JGW, de Lange WCM, Cobelens FGJ, van der Werf TS, Alffenaar JWC, End TB with precision treatment!. EUR RESPIR J 2016;47 (2):680-682 [PubMed]
Yates TA, Khan PY, Knight GM, Taylor JG, McHugh TD, Lipman M, White RG, Cohen T, Cobelens FG, Wood R, Moore DAJ, Abubakar I, The transmission of Mycobacterium tuberculosis in high burden settings. LANCET INFECT DIS 2016;16 (2):227-238 [PubMed]
Zuur MA, Akkerman OW, Touw DJ, van der Werf TS, Cobelens F, Burger DM, Grobusch MP, Alffenaar JWC, Dried blood spots can help decrease the burden on patients dually infected with multidrug-resistant tuberculosis and HIV. EUR RESPIR J 2016;48 (3):932-934 [PubMed]
Zwerling A, Gomez GB, Pennington J, Cobelens F, Vassall A, Dowdy DW, A simplified cost-effectiveness model to guide decision-making for shortened anti-tuberculosis treatment regimens. INT J TUBERC LUNG D 2016;20 (2):257-260 [PubMed]
Brouwer MA. Operational research on implementation of tuberculosis guidelines in Mozambique. S.l.: s.n.; 2015. 104p. ISBN 978-94-6259-700-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Health Alliance International, Maputo, Mozambique, Technical Assistance Unit. (Promotor(s): Cobelens FGJ; copromotor(s): van Leth FCM)
Denkinger CM, Dolinger D, Schito M, Wells W, Cobelens F, Pai M, Zignol M, Cirillo DM, Alland D, Casenghi M, Gallarda J, Boehme CC, Perkins MD, Target product profile of a molecular drug-susceptibility test for use in microscopy centers. J INFECT DIS 2015;211 (Suppl. 2):S39-S49 [PubMed]
García-Basteiro AL, Cobelens F, Triage tests: a new priority for tuberculosis diagnostics. LANCET RESP MED 2015;3 (3):177-178 [PubMed]
García-Basteiro AL, López-Varela E, Respeito D, González R, Naniche D, Manhiça I, Macete E, Cobelens F, Alonso PL, High tuberculosis burden among people living with HIV in southern Mozambique. EUR RESPIR J 2015;45 (2):547-549 [PubMed]
Gebhard A, van den Hof S, Cobelens F, How Do the New Definitions for Multidrug-Resistant Tuberculosis Treatment Outcomes Really Perform?. AM J RESP CRIT CARE 2015;192 (1):117 [PubMed]
Goovaerts O, Jennes W, Massinga-Loembé M, Ondoa P, Ceulemans A, Vereecken C, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L [Contributors: Kestens L, Colebunders R, Massinga-Loembé M, Mayanja H, Worodria W, Mascart F, van den Bergh R, Locht C, Reiss P, Cobelens F, Ondoa P, Pakker N, Mugerwa R]] , Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome. PLOS ONE 2015;10 (7):e0133924 [PubMed]
Hoang TTT, Nguyen NV, Dinh SN, Nguyen HB, Cobelens F, Thwaites G, Nguyen HT, Nguyen AT, Wright P, Wertheim HFL, Challenges in detection and treatment of multidrug resistant tuberculosis patients in Vietnam. BMC PUBLIC HEALTH 2015;15 (1):980 [PubMed]
Kapata N, Mbulo G, Cobelens F, de Haas P, Schaap A, Mwamba P, Mwanza W, Muvwimi M, Muyoyeta M, Moyo M, Mulenga L, Grobusch MP, Godfrey-Faussett P, Ayles H, The Second Zambian National Tuberculosis Drug Resistance survey - a comparison of conventional and molecular methods. TROP MED INT HEALTH 2015;20 (11):1492-1500 [PubMed]
Kerkhoff AD, Lawn SD, Schutz C, Burton R, Boulle A, Cobelens FJ, Meintjes G, Anemia, Blood Transfusion Requirements and Mortality Risk in Human Immunodeficiency Virus-Infected Adults Requiring Acute Medical Admission to Hospital in South Africa. OPEN FORUM INFECT DIS 2015;2 (4):ofv173 [PubMed]
Kerkhoff AD, Wood R, Cobelens FG, Gupta-Wright A, Bekker LG, Lawn SD, The predictive value of current haemoglobin levels for incident tuberculosis and/or mortality during long-term antiretroviral therapy in South Africa: a cohort study. BMC MED 2015;13 (1):70 [PubMed]
Knight GM, Colijn C, Shrestha S, Fofana M, Cobelens F, White RG, Dowdy DW, Cohen T, The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis. CLIN INFECT DIS 2015;61 (Suppl. 3):S147-S154 [PubMed]
Knight GM, Gomez GB, Dodd PJ, Dowdy D, Zwerling A, Wells WA, Cobelens F, Vassall A, White RG, The Impact and Cost-Effectiveness of a Four-Month Regimen for First-Line Treatment of Active Tuberculosis in South Africa. PLOS ONE 2015;10 (12):e0145796 [PubMed]
Lukoye D. Anti-tuberculosis drug resistance in Sub-Saharan Africa: The case of Uganda. S.l.: s.n.; 2015. 185p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij national Tuberculosis and Leprosy Program Kampala Uganda, -. (Promotor(s): Cobelens FGJ; copromotor(s): Joloba ML)
Lukoye D, Ssengooba W, Musisi K, Kasule GW, Cobelens FGJ, Joloba M, Gomez GB, Variation and risk factors of drug resistant tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis. BMC PUBLIC HEALTH 2015;15 (1):291 [PubMed]
Mkopi AB. Patient-centred tuberculosis treatment in Tanzania. S.l.: s.n.; 2015. 150p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Ifakara Health Institute, Dar es Salaam, -. (Promotor(s): Cobelens FGJ; copromotor(s): van Leth FCM, Geubbels E)
Ssengooba W, Cobelens FG, Nakiyingi L, Mboowa G, Armstrong DT, Manabe YC, Joloba ML, de Jong BC, High Genotypic Discordance of Concurrent Mycobacterium tuberculosis Isolates from Sputum and Blood of HIV-Infected Individuals. PLOS ONE 2015;10 (7):e0132581 [PubMed]
Theron G, Jenkins HE, Cobelens F, Abubakar I, Khan AJ, Cohen T, Dowdy DW, Data for action: collection and use of local data to end tuberculosis. LANCET 2015;386 (10010):2324-2333 [PubMed]
Trajman A, Durovni B, Saraceni V, Menezes A, Cordeiro-Santos M, Cobelens F, van den Hof S, Impact on Patients' Treatment Outcomes of XpertMTB/RIF Implementation for the Diagnosis of Tuberculosis: Follow-Up of a Stepped-Wedge Randomized Clinical Trial. PLOS ONE 2015;10 (4):e0123252 [PubMed]
van Kampen SC. Implementation of new diagnostics for tuberculosis: Bridging the gap betweeen global policy and local practice. S.l.: s.n.; 2015. 195p. ISBN 978-94-6259-790-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Royal Tropical Institute, Amsterdam, Royal Tropical Institute Biomedical Research. (Promotor(s): Klatser PR, Cobelens FGJ; copromotor(s): )
van't Hoog AH, Bergval I, Tukvadze N, Sengstake S, Aspindzelashvili R, Anthony RM, Cobelens F, The potential of a multiplex high-throughput molecular assay for early detection of first and second line tuberculosis drug resistance mutations to improve infection control and reduce costs: a decision analytical modeling study. BMC INFECT DIS 2015;15 (1):473 [PubMed]
Cobelens F, van Leth F, van 't Hoog A, Design of pragmatic trials of tuberculosis interventions. LANCET 2014;383 (9913):213-214 [PubMed]
Cordeiro-Santos M, Trajman A, Cobelens F, Durovni B, Gonçalves M, Bührer-Sékula S, Saraceni V, Tuberculosis Infection Control: Potential Benefit of a New Rapid Tuberculosis Test in a Human Immunodeficiency Virus/AIDS Reference Hospital. INFECT CONT HOSP EP 2014;35 (9):1206-1207 [PubMed]
Dowdy DW, Houben R, Cohen T, Pai M, Cobelens F, Vassall A, Menzies NA, Gomez GB, Langley I, Squire SB, White R, Impact and cost-effectiveness of current and future tuberculosis diagnostics: the contribution of modelling. INT J TUBERC LUNG D 2014;18 (9):1012-1018 [PubMed]
Dowdy DW, van't Hoog A, Shah M, Cobelens F, Cost-effectiveness of rapid susceptibility testing against second-line drugs for tuberculosis. INT J TUBERC LUNG D 2014;18 (6):647-654 [PubMed]
Durovni B, Saraceni V, Cordeiro-Santos M, Cavalcante S, Soares E, Lourenço C, Menezes A, van den Hof S, Cobelens F, Trajman A, Operational lessons drawn from pilot implementation of Xpert MTB/Rif in Brazil. B WORLD HEALTH ORGAN 2014;92 (8):613-617 [PubMed]
Durovni B, Saraceni V, van den Hof S, Trajman A, Cordeiro-Santos M, Cavalcante S, Menezes A, Cobelens F, Impact of replacing smear microscopy with Xpert MTB/RIF for diagnosing tuberculosis in Brazil: a stepped-wedge cluster-randomized trial. PLOS MED 2014;11 (12):e1001766 [PubMed]
Ezati N, Lukoye D, Wampande EM, Musisi K, Kasule GW, Cobelens FGJ, Kateete DP, Joloba ML, The Mycobacterium tuberculosis Uganda II family and resistance to first-line anti-tuberculosis drugs in Uganda. BMC INFECT DIS 2014;14:703 [PubMed]
Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L [Contributors: Kestens L, Colebunders R, Loembé MM, Mayanja H, Worodria W, Mascart F, van den Bergh R, Locht C, Reiss P, Cobelens F, Ondoa P, Pakker N, Mugerwa R]] , Antigen-Specific Interferon-Gamma Responses and Innate Cytokine Balance in TB-IRIS. PLOS ONE 2014;9 (11):e113101 [PubMed]
Kayigamba RF. Aspects of tuberculosis and HIV diagnosis, care and treatment in Rwandan health facilities: operational studies. S.l.: s.n.; 2014. 184p. ISBN 9789462592278 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Rwanda, -. (Promotor(s): Cobelens FGJ; copromotor(s): Bakker MI, Schim van der Loeff MF)
Kerkhoff AD, Wood R, Cobelens FG, Gupta-Wright A, Bekker LG, Lawn SD, Resolution of anaemia in a cohort of HIV-infected patients with a high prevalence and incidence of tuberculosis receiving antiretroviral therapy in South Africa. BMC INFECT DIS 2014;14 (1):3860 [PubMed]
Lukoye D, Katabazi FA, Musisi K, Kateete DP, Asiimwe BB, Okee M, Joloba ML, Cobelens FGJ, The T2 Mycobacterium tuberculosis genotype, predominant in Kampala, Uganda, shows negative correlation with antituberculosis drug resistance. ANTIMICROB AGENTS CH 2014;58 (7):3853-3859 [PubMed]
Mai NTH. Molecular epidemiology of tuberculosis in Vietnam. s.l.: s.n.; 2014. 154p. ISBN 978-94-6259-025-0 Proefschrift Radboud Universiteit Nijmegen, Geneeskunde. (Promotor(s): van Soolingen D, Cobelens FGJ; copromotor(s): )
Mayanja-Kizza H. Mycobacterium tuberculosis and human immunodeficiency virus type 1 interaction. Pathogenesis and disease modulation in dual infection. s.l.: s.n.; 2014. 126p. ISBN 978946291615 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Makerere University College of Health Sciences, Kampala, Uganda., -. (Promotor(s): Lange JMA, Cobelens FGJ; copromotor(s): )
Nijenbandring de Boer R, Cobelens FGJ, Kritski AL, Response from authors to letter from Eduardo Hernández-Garduño (TUBE 2013_75) Tuberculosis monoresistance and culture conversion in smokers Nijenbandring de Boer R, et al., "Delayed culture conversion due to cigarette smoking in active pulmonary tuberculosis patients, Tuberculosis (2014) January". TUBERCULOSIS 2014;94 (5):532 [PubMed]
Nijenbandring de Boer R, Oliveira e Souza Filho JBd, Cobelens F, Ramalho DdP, Campino Miranda PF, Logo Kd, Oliveira H, Mesquita E, Oliveira MM, Kritski A, Delayed culture conversion due to cigarette smoking in active pulmonary tuberculosis patients. TUBERCULOSIS 2014;94 (1):87-91 [PubMed]
Ssengooba W, Nakiyingi L, Armstrong DT, Cobelens FG, Alland D, Manabe YC, Dorman SE, Ellner JJ, Joloba ML, Clinical utility of a novel molecular assay in various combination strategies with existing methods for diagnosis of HIV-related tuberculosis in Uganda. PLOS ONE 2014;9 (9):e107595 [PubMed]
Thanh THT, Ngoc SD, Viet NN, van HN, Horby P, Cobelens FGJ, Wertheim HFL, A household survey on screening practices of household contacts of smear positive tuberculosis patients in Vietnam. BMC PUBLIC HEALTH 2014;14 (1):713 [PubMed]
Trajman A, Durovni B, Saraceni V, Cordeiro-Santos M, Cobelens F, van den Hof S, High positive predictive value of Xpert in a low rifampicin resistance prevalence setting. EUR RESPIR J 2014;44 (6):1711-1713 [PubMed]
Tran HTT, van den Bergh R, Vu TN, Laukens K, Worodria W, Loembé MM, Colebunders R, Kestens L, de Baetselier P, Raes G [Contributors: Kestens L, Colebunders R, Loembé MM, Mayanja-Kizza H, Worodria W, Mascart F, den Bergh R, Locht C, Reiss P, Cobelens F, Ondoa P, Pakker N, Mugerwa R]] , The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome. IMMUNOBIOLOGY 2014;219 (1):37-44 [PubMed]
Chinbuah MA, Adjuik M, Cobelens F, Koram KA, Abbey M, Gyapong M, Kager PA, Gyapong JO, Impact of treating young children with antimalarials with or without antibiotics on morbidity: a cluster-randomized controlled trial in Ghana. INT HEALTH 2013;5 (3):228-235 [PubMed]
Cobelens FGJ, For whom the bell tolls: isoniazid preventive therapy and tuberculosis drug resistance. SCI TRANSL MED 2013;5 (180):180fs12 [PubMed]
Falzon D, Gandhi N, Migliori GB, Sotgiu G, Cox HS, Holtz TH, Hollm-Delgado MG, Keshavjee S, Deriemer K, Centis R, D'Ambrosio L, Lange CG, Bauer M, Menzies D [Contributors: Ahuja SD, Ashkin D, Avendaño M, Banerjee R, Bauer M, Becerra MC, Benedetti A, Burgos M, Centis R, Chan ED, Chiang CY, Cobelens F, Cox H, D'Ambrosio L, de Lange WCM, DeRiemer K, Enarson D, Falzon D, Flanagan KL, Flood J, Gandhi N, Garcia-Garcia ML, Granich RM, Hollm-Delgado MG, Holtz TH, Hopewell P, Iseman MD, Jarlsberg LG, Keshavjee S, Kim HR, Koh WJ, Lancaster JL, Lange C, Leimane V, Leung CC, Li J, Menzies D, Migliori GB, Mitnick CD, Narita M, Nathanson E, Odendaal R, O'Riordan P, Pai M, Palmero D, Park SK, Pasvol G, Pena JM, Pérez-Guzmán C, Ponce-de-Leon A, Quelapio MID, Quy HT, Riekstina V, Robert J, Royce S, Salim M, Schaaf HS, Seung KJ, Shah L, Shean K, Shim TS, Shin SS, Shiraishi Y, Sifuentes-Osornio J, Sotgiu G, Strand MJ, Sung SW, Tabarsi P, Tupasi TE, Vargas MH, van Altena R, van der Walt ML, van der Werf TS, Viiklepp P, Westenhouse J, Yew WW, Yim JJ]] , Resistance to fluoroquinolones and second-line injectable drugs: impact on multidrug-resistant TB outcomes. EUR RESPIR J 2013;42 (1):156-168 [PubMed]
Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L [Contributors: Kestens L, Colebunders R, Loembé MM, Mayanja H, Worodria W, Mascart F, van den Bergh R, Locht C, Reiss P, Cobelens F, Ondoa P, Pakker N, Mugerwa R]] , LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients. PLOS ONE 2013;8 (11):e81856 [PubMed]
Hoa NB, Cobelens FGJ, Sy DN, Nhung NV, Borgdorff MW, Tiemersma EW, First national tuberculin survey in Viet Nam: characteristics and association with tuberculosis prevalence. INT J TUBERC LUNG D 2013;17 (6):738-744 [PubMed]
Huyen MNT, Buu TN, Tiemersma E, Lan NTN, Dung NH, Kremer K, Soolingen DV, Cobelens FGJ, Tuberculosis relapse in Vietnam is significantly associated with Mycobacterium tuberculosis Beijing genotype infections. J INFECT DIS 2013;207 (10):1516-1524 [PubMed]
Huyen MNT, Cobelens FGJ, Buu TN, Lan NTN, Dung NH, Kremer K, Tiemersma EW, van Soolingen D, Epidemiology of isoniazid resistance mutations and their effect on tuberculosis treatment outcomes. ANTIMICROB AGENTS CH 2013;57 (8):3620-3627 [PubMed]
Huyen MNT, Kremer K, Lan NTN, Buu TN, Cobelens FGJ, Tiemersma EW, de Haas P, van Soolingen D, Clustering of Beijing genotype Mycobacterium tuberculosis isolates from the Mekong delta in Vietnam on the basis of variable number of tandem repeat versus restriction fragment length polymorphism typing. BMC INFECT DIS 2013;13 (1):63 [PubMed]
Huyen MNT, Tiemersma EW, Kremer K, de Haas P, Lan NTN, Buu TN, Sola C, Cobelens FGJ, van Soolingen D, Characterisation of Mycobacterium tuberculosis isolates lacking IS6110 in Viet Nam. INT J TUBERC LUNG D 2013;17 (11):1479-1485 [PubMed]
Kapata N, Chanda-Kapata P, Bates M, Mwaba P, Cobelens F, Grobusch MP, Zumla A, Multidrug-resistant TB in Zambia: review of national data from 2000 to 2011. TROP MED INT HEALTH 2013;18 (11):1386-1391 [PubMed]
Kapata N, Chanda-Kapata P, O'Grady J, Bates M, Mwaba P, Janssen S, Marais B, Cobelens F, Grobusch M, Zumla A, Trends in childhood tuberculosis in Zambia: a situation analysis. J TROP PEDIATRICS 2013;59 (2):134-139 [PubMed]
Kayigamba FR, Bakker MI, Mugisha V, de Naeyer L, Gasana M, Cobelens F, Schim van der Loeff M, Adherence to tuberculosis treatment, sputum smear conversion and mortality: a retrospective cohort study in 48 rwandan clinics. PLOS ONE 2013;8 (9):e73501 [PubMed]
Nguyen BH. Tuberculosis burden in Vietnam. What have we gained from the first national prevalence survey?. s.l.: s.n.; 2013. 130p. ISBN 9789461916044 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Borgdorff MW, Cobelens FGJ; copromotor(s): Tiemersma EW, Nhung NV)
Sendagire I. Operational aspects of diagnosing and treating tubercolosis and HIV infection in Ugandan urban areas. s.l.: s.n.; 2013. 128p. ISBN 9789461916709 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Cobelens FGJ; copromotor(s): Schim van der Loeff MF , Konde-Lule J)
Tran HTT, van den Bergh R, Loembé MM, Worodria W, Mayanja-Kizza H, Colebunders R, Mascart F, Stordeur P, Kestens L, de Baetselier P, Raes G [Contributors: Kestens L, Colebunders R, Loembé MM, Mayanja-Kizza H, Worodria W, Mascart F, van den Berg R, Locht C, Reiss P, Cobelens F, Ondoa P, Pakker N, Mugerwa R]] , Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS 2013;27 (11):1725-1734 [PubMed]
van't Hoog AH, Cobelens F, Vassall A, van Kampen S, Dorman SE, Alland D, Ellner J, Optimal triage test characteristics to improve the cost-effectiveness of the Xpert MTB/RIF assay for TB diagnosis: a decision analysis. PLOS ONE 2013;8 (12):e82786 [PubMed]
Wells WA, Boehme CC, Cobelens FGJ, Daniels C, Dowdy D, Gardiner E, Gheuens J, Kim P, Kimerling ME, Kreiswirth B, Lienhardt C, Mdluli K, Pai M, Perkins MD, Peter T, Zignol M, Zumla A, Schito M, Alignment of new tuberculosis drug regimens and drug susceptibility testing: a framework for action. LANCET INFECT DIS 2013;13 (5):449-458 [PubMed]
Bergval I, Sengstake S, Brankova N, Levterova V, Abadía E, Tadumaze N, Bablishvili N, Akhalaia M, Tuin K, Schuitema A, Panaiotov S, Bachiyska E, Kantardjiev T, de Zwaan R, Schürch A, van Soolingen D, van 't Hoog A, Cobelens F, Aspindzelashvili R, Sola C, Klatser P, Anthony R, Combined Species Identification, Genotyping, and Drug Resistance Detection of Mycobacterium tuberculosis Cultures by MLPA on a Bead-Based Array. PLOS ONE 2012;7 (8):e43240 [PubMed]
Buu TN, van Soolingen D, Huyen MNT, Lan NTN, Quy HT, Tiemersma EW, Kremer K, Borgdorff MW, Cobelens FGJ, Increased Transmission of Mycobacterium tuberculosis Beijing Genotype Strains Associated with Resistance to Streptomycin: A Population-Based Study. PLOS ONE 2012;7 (8):e42323 [PubMed]
Cobelens F, Relative reproductive fitness of the W-Beijing genotype. INT J TUBERC LUNG D 2012;16 (3):287 [PubMed]
Cobelens F, van den Hof S, Pai M, Squire SB, Ramsay A, Kimerling ME [Contributors: Bhan A, Chin D, Dewan P, Durovni B, Dye C, Goldhaber-Fiebert J, Harper I, Langley I, Leeflang M, Lienhardt C, McCray E, Mukadi YD, Nicol M, O'Brien R, Ridderhof J, Schito M, Small P, Vassall A, Zhao Y]] , Which New Diagnostics for Tuberculosis, and When?. J INFECT DIS 2012;205 (2):S191-S198 [PubMed]
Cobelens F, van Kampen S, Ochodo E, Atun R, Lienhardt C, Research on Implementation of Interventions in Tuberculosis Control in Low- and Middle-Income Countries: A Systematic Review. PLOS MED 2012;9 (12):e1001358 [PubMed]
Conesa-Botella A, Goovaerts O, Massinga-Loembé M, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Colebunders R, Kestens L [Contributors: Mascart F, van den Bergh R, Locht C, Reiss P, Cobelens F, Ondoa P, Pakker N, Mugerwa R]] , Low prevalence of vitamin D deficiency in Ugandan HIV-infected patients with and without tuberculosis. INT J TUBERC LUNG D 2012;16 (11):1517-1521 [PubMed]
Dowdy D, Vassall A, Cobelens F, Tuberculosis control in crisis: economic honesty and comparative effectiveness. INT J TUBERC LUNG D 2012;16 (8):1131-1132 [PubMed]
Hedt BL, van Leth F, Zignol M, Cobelens F, van Gemert W, Nhung NV, Lyepshina S, Egwaga S, Cohen T, Multidrug Resistance Among New Tuberculosis Cases Detecting Local Variation Through Lot Quality-assurance Sampling. EPIDEMIOLOGY 2012;23 (2):293-300 [PubMed]
Hoa NB, Cobelens FGJ, Sy DN, Nhung NV, Borgdorff MW, Tiemersma EW, Yield of interview screening and chest X-ray abnormalities in a tuberculosis prevalence survey. INT J TUBERC LUNG D 2012;16 (6):762-767 [PubMed]
Huyen MNT, Kremer K, Lan NTN, Cobelens FGJ, Buu TN, Dung NH, Caws M, Tiemersma EW, van Soolingen D, Mixed Tuberculosis Infections in Rural South Vietnam. J CLIN MICROBIOL 2012;50 (5):1586-1592 [PubMed]
Kapata N, Chanda-Kapata P, Grobusch MP, O'Grady J, Schwank S, Bates M, Jansenn S, Mwinga A, Cobelens F, Mwaba P, Zumla A, Scale-up of TB and HIV programme collaborative activities in Zambia - a 10-year review. TROP MED INT HEALTH 2012;17 (6):760-766 [PubMed]
Manabe YC, Worodria W, Cobelens F, Empirical tuberculosis treatment or improved diagnostics?. INT J TUBERC LUNG D 2012;16 (2):280; author reply 280-280; author reply 281 [PubMed]
Sendagire I , Cobelens F, Kambugu A, Konde-Lule J, Schim van der Loeff M, Frequency and Predictors for Late Start of Antiretroviral Therapy in Primary Care Clinics, Kampala, Uganda. JAIDS-J ACQ IMM DEF 2012;61 (3):E33-E39 [PubMed]
Sendagire I , Schim van der Loeff M, Kambugu A, Konde-Lule J, Cobelens F, Urban Movement and Alcohol Intake Strongly Predict Defaulting from Tuberculosis Treatment: An Operational Study. PLOS ONE 2012;7 (5):e35908 [PubMed]
Vu DH, van Rein N, Cobelens FGJ, Nguyen TTH, Le VH, Brouwers JRBJ, Suspected tuberculosis case detection and referral in private pharmacies in Viet Nam. INT J TUBERC LUNG D 2012;16 (12):1625-1629 [PubMed]
Worodria W, Menten J, Massinga-Loembe M, Mazakpwe D, Bagenda D, Koole O, Mayanja-Kizza H, Kestens L, Mugerwa R, Reiss P, Colebunders R [Contributors: Kestens L, Colebunders R, Massinga-Loembé M, Mayanja H, Worodria W, Mascart F, van den Bergh R, Locht C, Reiss P, Cobelens F, Ondoa P, Pakker N, Mugerwa R]] , Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection. ANTIVIR THER 2012;17 (5):841-848 [PubMed]
Zumla A, Cobelens F, Operational research and MDG tuberculosis control targets. LANCET INFECT DIS 2012;12 (4):262-263 [PubMed]
Zwerling A, van den Hof S, Scholten J, Cobelens F, Menzies D, Pai M, Interferon-gamma release assays for tuberculosis screening of healthcare workers: a systematic review. THORAX 2012;67 (1):62-70 [PubMed]
Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, Huang L, Caceres T, Mehdiyev R, Raymond L, Whitelaw A, Sagadevan K, Alexander H, Albert H, Cobelens F, Cox H, Alland D, Perkins MD, Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. LANCET 2011;377 (9776):1495-1505 [PubMed]
Buu TN. Tuberculosis epidemiology in Vietnam: the role of HIV, drug resistance and genotype. s.l.: s.n.; 2011. 146p. ISBN 9789081586337 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Borgdorff MW; copromotor(s): Cobelens FGJ, Lan NTN)
Conesa-Botella A, Loembé MM, Manabe YC, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Miri M, Mbabazi O, Koole O, Kestens L, Colebunders R [Contributors: Kestens L, Colebunders R, Massinga Loembé M, Mayanja-Kizza H, Worodria W, Mascart F, van den Bergh R, Locht C, Reiss P, Cobelens F, Ondoa P, Pakker N, Mugerwa R]] , Urinary lipoarabinomannan as predictor for the tuberculosis immune reconstitution inflammatory syndrome. JAIDS-J ACQ IMM DEF 2011;58 (5):463-468 [PubMed]
Hoa NB, Cobelens FGJ, Sy DN, Nhung NV, Borgdorff MW, Tiemersma EW, Diagnosis and Treatment of Tuberculosis in the Private Sector, Vietnam. EMERG INFECT DIS 2011;17 (3):562-564 [PubMed]
Hoa NB, Tiemersma EW, Sy DN, Nhung NV, Gebhard A, Borgdorff MW, Cobelens FGJ, Household expenditure and tuberculosis prevalence in VietNam: prediction by a set of household indicators. INT J TUBERC LUNG D 2011;15 (1):32-37 [PubMed]
Hoa NB, Tiemersma EW, Sy DN, Nhung NV, Vree M, Borgdorff MW, Cobelens FGJ, Health-seeking behaviour among adults with prolonged cough in Vietnam. TROP MED INT HEALTH 2011;16 (10):1260-1267 [PubMed]
Kik SV, Mensen M, Beltman M, Gijsberts M, van Ameijden EJC, Cobelens FGJ, Erkens C, Borgdorff MW, Verver S, Risk of travelling to the country of origin for tuberculosis among immigrants living in a low-incidence country. INT J TUBERC LUNG D 2011;15 (1):38-43 [PubMed]
Konde-Lule J, Makumbi F, Pakker N, Muyinda A, Mubiru M, Cobelens FGJ, Effect of changing antiretroviral treatment eligibility criteria on patient load in Kampala, Uganda. AIDS CARE 2011;23 (1):35-41 [PubMed]
Lienhardt C, Cobelens FGJ, Operational research for improved tuberculosis control: the scope, the needs and the way forward. INT J TUBERC LUNG D 2011;15 (1):6-13 [PubMed]
Lukoye D, Cobelens FGJ, Ezati N, Kirimunda S, Adatu FE, Lule JK, Nuwaha F, Joloba ML, Rates of Anti-Tuberculosis Drug Resistance in Kampala-Uganda Are Low and Not Associated with HIV Infection. PLOS ONE 2011;6 (1):e16130 [PubMed]
Squire SB, Ramsay ARC, van den Hof S, Millington KA, Langley I, Bello G, Kritski A, Detjen A, Thomson R, Cobelens F, Mann GH, Making innovations accessible to the poor through implementation research. INT J TUBERC LUNG D 2011;15 (7):862-870 [PubMed]
van Beek SC, Nhung NV, Sy DN, Sterk PJ, Tiemersma EW, Cobelens FGJ, Measurement of exhaled nitric oxide as a potential screening tool for pulmonary tuberculosis. INT J TUBERC LUNG D 2011;15 (2):185-191 [PubMed]
Vassall A, van Kampen S, Sohn H, Michael JS, John KR, den Boon S, Davis JL, Whitelaw A, Nicol MP, Gler MT, Khaliqov A, Zamudio C, Perkins MD, Boehme CC, Cobelens F, Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a cost-effectiveness analysis. PLOS MED 2011;8 (11):e1001120 [PubMed]
Worodria W, Massinga-Loembe M, Mazakpwe D, Luzinda K, Menten J, van Leth F, Mayanja-Kizza H, Kestens L, Mugerwa RD, Reiss P, Colebunders R [Contributors: Kestens L, Colebunders R, Ondoa P, Massinga Loembe M, Mayanja H, Worodria W, Mascart F, van den Bergh R, Locht C, Reiss P, Cobelens F, Pakker N, Mugerwa R]] , Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy. JAIDS-J ACQ IMM DEF 2011;58 (1):32-37 [PubMed]
Buu TN, Huyen MNT, van Soolingen D, Lan NTN, Quy HT, Tiemersma EW, Borgdorff MW, Cobelens FGJ, The Mycobacterium tuberculosis Beijing Genotype Does Not Affect Tuberculosis Treatment Failure in Vietnam. CLIN INFECT DIS 2010;51 (8):879-886 [PubMed]
Buu TN, Quy HT, Qui NC, Lan NTN, Sy DN, Cobelens FGJ, Decrease in risk of tuberculosis infection despite increase in tuberculosis among young adults in urban Vietnam. INT J TUBERC LUNG D 2010;14 (3):289-295 [PubMed]
Buu TN, van Soolingen D, Huyen MNT, Lan NNT, Quy HT, Tiemersma EW, Borgdorff MW, Cobelens FGJ, Tuberculosis Acquired Outside of Households, Rural Vietnam. EMERG INFECT DIS 2010;16 (9):1466-1468 [PubMed]
Chonde TM, Basra D, Mfinanga SGM, Range N, Lwilla F, Shirima RP, van Deun A, Zignol M, Cobelens FG, Egwaga SM, van Leth F, National anti-tuberculosis drug resistance study in Tanzania. INT J TUBERC LUNG D 2010;14 (8):967-972 [PubMed]
Hoa NB, Sy DN, Nhung NV, Tiemersma EW, Borgdorff MW, Cobelens FGJ, National survey of tuberculosis prevalence in Viet Nam. B WORLD HEALTH ORGAN 2010;88 (4):273-280 [PubMed]
Huyen MNT, Tiemersma EW, Lan NTN, Cobelens FGJ, Dung NH, Sy DN, Buu TN, Kremer K, Hang PT, Caws M, O'Brien R, van Soolingen D, Validation of the GenoType(R) MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam. BMC INFECT DIS 2010;10 (1):149 [PubMed]
Kik SV, Franken WPJ, Mensen M, Cobelens FGJ, Kamphorst M, Arend SM, Erkens C, Gebhard A, Borgdorff MW, Verver S, Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts. EUR RESPIR J 2010;35 (6):1346-1353 [PubMed]
Sendagire I , Schim van der Loeff M, Mubiru M, Konde-Lule J, Cobelens F, Long Delays and Missed Opportunities in Diagnosing Smear-Positive Pulmonary Tuberculosis in Kampala, Uganda: A Cross-Sectional Study. PLOS ONE 2010;5 (12):e14459 [PubMed]
Sendagire I , Schreuder I, Mubiru M, van der Loeff MS, Cobelens F, Konde-Lule J, Low HIV testing rates among tuberculosis patients in Kampala, Uganda. BMC PUBLIC HEALTH 2010;10 (1):177 [PubMed]
Thanh DH, Sy DN, Linh ND, Hoan TM, Dien HT, Thuy TB, Hoa NP, Tung LB, Cobelens F, HIV infection among tuberculosis patients in Vietnam: prevalence and impact on tuberculosis notification rates. INT J TUBERC LUNG D 2010;14 (8):986-993 [PubMed]
Altes HK, Dijkstra F, Lugnèr A, Cobelens F, Wallinga J, Targeted BCG Vaccination Against Severe Tuberculosis in Low-prevalence Settings Epidemiologic and Economic Assessment. EPIDEMIOLOGY 2009;20 (4):562-568 [PubMed]
Anthony RM, Cobelens FGJ, Gebhard A, Klatser PR, Lumb R, Rüsch-Gerdes S, van Soolingen D, Liquid culture for Mycobacterium tuberculosis: proceed, but with caution. INT J TUBERC LUNG D 2009;13 (9):1051-1053 [PubMed]
Buu TN, Huyen MN, Lan NTN, Quy HT, Hen NV, Zignol M, Borgdorff MW, Cobelens FGJ, van Soolingen D, The Beijing genotype is associated with young age and multidrug-resistant tuberculosis in rural Vietnam. INT J TUBERC LUNG D 2009;13 (7):900-906 [PubMed]
Buu TN, Huyen MNT, Lan NNT, Quy HT, Hen NV, Zignol M, Borgdorff MW, van Soolingen D, Cobelens FGJ, Mycobacterium tuberculosis Genotype and Case Notification Rates, Rural Vietnam, 2003-2006. EMERG INFECT DIS 2009;15 (10):1570-1577 [PubMed]
Chiang CY, Glaziou P, Enarson DA, Cobelens F, Lew WJ, Protecting patients' rights, ensuring safety and quality assurance in tuberculosis prevalence surveys. INT J TUBERC LUNG D 2009;13 (1):27-31 [PubMed]
Egwaga S, Mkopi A, Range N, Haag-Arbenz V, Baraka A, Grewal P, Cobelens F, Mshinda H, Lwilla F, van Leth F, Patient-centred tuberculosis treatment delivery under programmatic conditions in Tanzania: a cohort study. BMC MED 2009;7 (1):80 [PubMed]
Kik SV, Franken WPJ, Arend SM, Mensen M, Cobelens FGJ, Kamphorst M, van Dissel JT, Borgdorff MW, Verver S, Interferon-gamma release assays in immigrant contacts and effect of remote exposure to Mycobacterium tuberculosis. INT J TUBERC LUNG D 2009;13 (7):820-828 [PubMed]
Lönnroth K, Holtz TH, Cobelens F, Chua J, van Leth F, Tupasi T, Williams B, Inclusion of information on risk factors, socio-economic status and health seeking in a tuberculosis prevalence survey. INT J TUBERC LUNG D 2009;13 (2):171-176 [PubMed]
Mack U, Migliori GB, Sester M, Rieder HL, Ehlers S, Goletti D, Bossink A, Magdorf K, Hölscher C, Kampmann B, Arend SM, Detjen A, Bothamley G, Zellweger JP, Milburn H, Diel R, Ravn P, Cobelens F, Cardona PJ, Kan B, Solovic I, Duarte R, Cirillo DM, LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. EUR RESPIR J 2009;33 (5):956-973 [PubMed]
Borgen K, Koster B, Meijer H, Kuyvenhoven V, van der Sande M, Cobelens F, Evaluation of a large-scale tuberculosis contact investigation in the Netherlands. EUR RESPIR J 2008;32 (2):419-425 [PubMed]
Chonde TM, Doulla B, van Leth F, Mfinanga SGM, Range N, Lwilla F, Mfaume SM, van Deun A, Zignol M, Cobelens FG, Egwaga SM, Implementation of a national anti-tuberculosis drug resistance survey in Tanzania. BMC PUBLIC HEALTH 2008;8:427 [PubMed]
Cobelens FGJ, Heldal E, Kimerling ME, Mitnick CD, Podewils LJ, Ramachandran R, Rieder HL, Weyer K, Zignol M, Scaling up programmatic management of drug-resistant tuberculosis: a prioritized research agenda. PLOS MED 2008;5 (7):e150-1042 [PubMed]
Egwaga S, Range N, Lwilla F, Mkopi A, Barongo V, Mtenga S, Mshinda H, Cobelens F, Haag V, van Leth F, Grewal P, Assessment of patient preference in allocation and observation of anti-tuberculosis medication in three districts in Tanzania. PATIENT PREFER ADHER 2008;2:1-6 [PubMed]
Glaziou P, van der Werf MJ, Onozaki I, Dye C, Borgdorff MW, Chiang CY, Cobelens F, Enarson DA, Gopi PG, Holtz TH, Kim SJ, van Leth F, Lew WJ, Lonnroth K, van Maaren P, Narayanan PR, Williams B, Tuberculosis prevalence surveys: rationale and cost. INT J TUBERC LUNG D 2008;12 (9):1003-1008 [PubMed]
Kik SV, Verver S, van Soolingen D, de Haas PEW, Cobelens FG, Kremer K, van Deutekom H, Borgdorff MW, Tuberculosis outbreaks predicted by characteristics of first patients in a DNA fingerprint cluster. AM J RESP CRIT CARE 2008;178 (1):96-104 [PubMed]
van Duc L, Vree M, Cobelens FG, Phuc LT, Sy DN, High tuberculosis prevalence in a psychiatric hospital in Vietnam. INT J TUBERC LUNG D 2008;12 (6):686-688 [PubMed]
van Leth F, Cobelens FG, Onozaki I, Organisation of a tuberculosis prevalence survey. INT J TUBERC LUNG D 2008;12 (12):1365-1369 [PubMed]
Arend SM, Thijsen SFT, Leyten EMS, Bouwman JJM, Franken WPJ, Koster BFPJ, Cobelens FGJ, van Houte AJ, Bossink AWJ, Comparison of two interferon-gamma assays and tuberculin skin test for tracing tuberculosis contacts. AM J RESP CRIT CARE 2007;175 (6):618-627 [PubMed]
Cobelens FGJ, Tuberculosis risks for health care workers in Africa. CLIN INFECT DIS 2007;44 (3):324-326 [PubMed]
Cobelens FGJ, Menzies D, Farhat M, False-positive tuberculin reactions due to non-tuberculous mycobacterial infections. INT J TUBERC LUNG D 2007;11 (8):934-935 [PubMed]
Drobniewski F, Cobelens F, Zellweger JP, Use of Gamma-interferon assays in low- and medium-prevalence countries in Europe: a consensus statement of a Wolfheze Workshop organised by KNCV/EuroTB, Vilnius Sept 2006. EUROSURVEILLANCE 2007;12 (7):E070726.2 [PubMed]
Duc LV, Vree M, Sy DN, Co NV, Borgdorff MW, Cobelens FGJ, Steep increases in tuberculosis notification among young men in the industrialised districts of Danang, Vietnam. INT J TUBERC LUNG D 2007;11 (5):567-570 [PubMed]
Egwaga SM, Chonde TM, Matee MI, Mfinanga SG, Ngowi PE, Lwilla F, Cobelens FG, Low specificity of HIV-testing on sputum specimens kept at ambient temperatures for 4 to 7 days: a blinded comparison. BMC CLIN PATHOL 2007;7:8 [PubMed]
Haar CH, Cobelens FGJ, Kalisvaart NA, van der Have JJ, van Deutekom H, Hiv-testbeleid bij tuberculosepatiënten in Nederland. NED TIJDSCHR GENEESKD 2007;151 (48):2674-2679 [PubMed]
Haar CH, Cobelens FGJ, Kalisvaart NA, van der Have JJ, van Gerven PJHJ, van Soolingen D, Tuberculosis drug resistance and HIV infection, the Netherlands. EMERG INFECT DIS 2007;13 (5):776-778 [PubMed]
Haar CH, Cobelens FGJ, Kalisvaart NA, van Gerven PJHJ, van der Have JJ, HIV-related mortality among tuberculosis patients in The Netherlands, 1993-2001. INT J TUBERC LUNG D 2007;11 (9):1038-1041 [PubMed]
Hung NV, Sy DN, Anthony RM, Cobelens FGJ, van Soolingen D, Fluorescence microscopy for tuberculosis diagnosis. LANCET INFECT DIS 2007;7 (4):238-9; author reply 239-40 [PubMed]
Huong NT. Tuberculosis control in Vietnam: does DOTS do it?. s.l.: s.n.; 2007. 158p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Borgdorff MW; copromotor(s): Co NV, Cobelens FGJ)
Huong NT, Vree M, Duong BD, Khanh VT, Loan VT, Co NV, Borgdorff MW, Cobelens FG, Delays in the diagnosis and treatment of tuberculosis patients in Vietnam: a cross-sectional study. BMC PUBLIC HEALTH 2007;7:110 [PubMed]
Leyten EMS, Arend SM, Prins C, Cobelens FGJ, Ottenhoff THM, van Dissel JT, Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation. CLIN VACCINE IMMUNOL 2007;14 (7):880-885 [PubMed]
Tran NB, Houben RMGJ, Hoang TQ, Nguyen TNL, Borgdorff MW, Cobelens FGJ, HIV and tuberculosis in Ho Chi Minh City, Vietnam, 1997-2002. EMERG INFECT DIS 2007;13 (10):1463-1469 [PubMed]
Vree M. The impact of tuberculosis control in Vietnam. s.l.: s.n.; 2007. 160p. ISBN 9789064641510 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Borgdorff MW; copromotor(s): Co NV, Cobelens FGJ)
Vree M, Bui DD, Dinh NS, Nguyen VC, Borgdorff MW, Cobelens FGJ, Tuberculosis trends, Vietnam. EMERG INFECT DIS 2007;13 (5):796-797 [PubMed]
Vree M, Hoa NB, Sy DN, Co NV, Cobelens FGJ, Borgdorff MW, Low tuberculosis notification in mountainous Vietnam is not due to low case detection: a cross-sectional survey. BMC INFECT DIS 2007;7 (1):109 [PubMed]
Vree M, Huong NT, Duong BD, Co NV, Sy DN, Cobelens FG, Borgdorff MW, High mortality during tuberculosis treatment does not indicate long diagnostic delays in Vietnam: a cohort study. BMC PUBLIC HEALTH 2007;7:210 [PubMed]
Vree M, Huong NT, Duong BD, Sy DN, van LN, Co NV, Cobelens FGJ, Borgdorff MW, Mortality and failure among tuberculosis patients who did not complete treatment in Vietnam: a cohort study. BMC PUBLIC HEALTH 2007;7:134 [PubMed]
Vree M, Huong NT, Duong BD, Sy DN, van LN, Hung NV, Co NV, Borgdorff MW, Cobelens FG, Survival and relapse rate of tuberculosis patients who successfully completed treatment in Vietnam. INT J TUBERC LUNG D 2007;11 (4):392-397 [PubMed]
Cobelens FG, Egwaga SM, van Ginkel T, Muwinge H, Matee MI, Borgdorff MW, Tuberculin skin testing in patients with HIV infection: limited benefit of reduced cutoff values. CLIN INFECT DIS 2006;43 (5):634-639 [PubMed]
Egwaga SM, Cobelens FG, Muwinge H, Verhage C, Kalisvaart N, Borgdorff MW, The impact of the HIV epidemic on tuberculosis transmission in Tanzania. AIDS 2006;20 (6):915-921 [PubMed]
Haar CH, Cobelens FGJ, Kalisvaart NA, van der Have JJ, van Gerven PJHJ, van Deutekom H, HIV prevalence among tuberculosis patients in The Netherlands, 1993-2001: trends and risk factors. INT J TUBERC LUNG D 2006;10 (7):768-774 [PubMed]
Huong NT, Duong BD, Co NV, Quy HT, Tung LB, Broekmans JF, Bosman MC, Verhage C, Kalisvaart N, Borgdorff MW, Cobelens FG, Tuberculosis epidemiology in six provinces of Vietnam after the introduction of the DOTS strategy. INT J TUBERC LUNG D 2006;10 (9):963-969 [PubMed]
Huong NT, Duong BD, Linh NN, van LN, Co NV, Broekmans JF, Cobelens FG, Borgdorff MW, Evaluation of sputum smear microscopy in the National Tuberculosis Control Programme in the north of Vietnam. INT J TUBERC LUNG D 2006;10 (3):277-282 [PubMed]
Huong NT, Lan NTN, Cobelens FGJ, Duong BD, Co NV, Bosman MC, Kim SJ, van Soolingen D, Borgdorff MW, Antituberculosis drug resistance in the south of Vietnam: prevalence and trends. J INFECT DIS 2006;194 (9):1226-1232 [PubMed]
Quy HT, Buu TN, Cobelens FGJ, Lan NTN, Lambregts CSB, Borgdorff MW, Drug resistance among smear-positive tuberculosis patients in Ho Chi Minh City, Vietnam. INT J TUBERC LUNG D 2006;10 (2):160-166 [PubMed]
Quy HT, Cobelens FGJ, Lan NTN, Buu TN, Lambregts CSB, Borgdorff MW, Treatment outcomes by drug resistance and HIV status among tuberculosis patients in Ho Chi Minh City, Vietnam. INT J TUBERC LUNG D 2006;10 (1):45-51 [PubMed]
Berkel GM, Cobelens FGJ, de Vries G, Draayer-Jansen IWE, Borgdorff MW, Tuberculin skin test: estimation of positive and negative predictive values from routine data. INT J TUBERC LUNG D 2005;9 (3):310-316 [PubMed]
Kuijvenhoven JV, Cobelens FGJ, Grootschalig contactonderzoek op tuberculose in Zeist. NED TIJDSCHR GENEESKD 2005;149 (35):1925-1928
Cobelens FGJ, van Schothorst HJ, Wertheim-van Dillen PME, Ligthelm RJ, Paul-Steenstra IS, van Thiel PPAM, Epidemiology of hepatitis B infection among expatriates in Nigeria. CLIN INFECT DIS 2004;38 (3):370-376 [PubMed]
van Hest R, Baars H, Kik S, van Gerven P, Trompenaars MC, Kalisvaart N, Keizer S, Borgdorff M, Mensen M, Cobelens F, Hepatotoxicity of rifampin-pyrazinamide and isoniazid preventive therapy and tuberculosis treatment. CLIN INFECT DIS 2004;39 (4):488-496 [PubMed]
Vreugdenhil CJ, Scheper FY, Hoogstraatte SR, Smolders M, Gikunda S, Cobelens FG, Kager PA, Comparison of the parasitologic efficacy of amodiaquine and sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria in the Bungoma district of western Kenya. AM J TROP MED HYG 2004;71 (5):537-541 [PubMed]
Wagenaar JFP, Falke THF, Nam NV, Binh TQ, Smits HL, Cobelens FGJ, de Vries PJ, Rapid serological assays for leptospirosis are of limited value in southern Vietnam. ANN TROP MED PARASIT 2004;98 (8):843-850 [PubMed]
Borgdorff MW, Cobelens FG, Withholding TB treatment while awaiting susceptibility results. INT J TUBERC LUNG D 2003;7 (7):705; author reply 705-705; author reply 706 [PubMed]
Cobelens FGJ, Draayer-Jansen EWE, Schepp-Beelen ACHM, van Gerven PJHJ, van Kessel RJ, van Deutekom H, Beperkte deelname aan tuberculinescreening onder reizigers naar landen met hoge tuberculose-incidentie; reden om voor sommigen BCG-vaccinatie te overwegen. NED TIJDSCHR GENEESKD 2003;147 (12):561-565
Cobelens F, van Deutekom H, Draayer-Jansen I, Schepp-Beelen A, van Gerven P, Mensen M, Tuberculin skin test reactions by time of reading among Dutch travellers. INT J TUBERC LUNG D 2003;7 (8):758-763 [PubMed]
Lambregts-van Weezenbeek CSB, Cobelens FGJ, Mensen EAM, De tuberculinetest in Nederland: nieuw beleid voor een oude test; richtlijn van de Commissie voor Praktische Tuberculosebestrijding. NED TIJDSCHR GENEESKD 2003;147 (12):543-546
Verbon A, Cobelens FGJ, Indicaties voor en betekenis van de tuberculinetest in Nederland. NED TIJDSCHR GENEESKD 2003;147 (12):539-543 [PubMed]
Adjuik M, Agnamey P, Babiker A, Borrmann S, Brasseur P, Cisse M, Cobelens F, Diallo S, Faucher JF, Garner P, Gikunda S, Kremsner PG, Krishna S, Lell B, Loolpapit M, Matsiegui PB, Missinou MA, Mwanza J, Ntoumi F, Olliaro P, Osimbo P, Rezbach P, Some E, Taylor WRJ, Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. LANCET 2002;359 (9315):1365-1372 [PubMed]
Cobelens FGJ, Groen J, Osterhaus ADME, Leentvaar-Kuipers A, Wertheim-van Dillen PME, Kager PA, Incidence and risk factors of probable dengue virus infection among Dutch travellers to Asia. TROP MED INT HEALTH 2002;7 (4):331-338 [PubMed]
Cobelens F, Borgdorff M, Boosting, BCG, and time of reading in tuberculin skin testing. LANCET 2001;358 (9298):2014 [PubMed]
Cobelens FG, van Deutekom H, Draayer-Jansen IW, Schepp-Beelen AC, van Gerven PJ, van Kessel RP, Mensen ME, Association of tuberculin sensitivity in Dutch adults with history of travel to areas of with a high incidence of tuberculosis. CLIN INFECT DIS 2001;33 (3):300-304 [PubMed]
Cobelens FG, Kooij S, Warris-Versteegen A, Visser LG, Typhoid fever in group travelers: opportunity for studying vaccine efficacy. J TRAVEL MED 2000;7 (1):19-24 [PubMed]
Cobelens FG, van Deutekom H, Draayer-Jansen IW, Schepp-Beelen AC, van Gerven PJ, van Kessel RP, Mensen ME, Risk of infection with Mycobacterium tuberculosis in travellers to areas of high tuberculosis endemicity. LANCET 2000;356 (9228):461-465 [PubMed]
Schultsz C, van den Ende J, Cobelens F, Vervoort T, van Gompel A, Wetsteyn JC, Dankert J, Diarrheagenic Escherichia coli and acute and persistent diarrhea in returned travelers. J CLIN MICROBIOL 2000;38 (10):3550-3554 [PubMed]
Wetsteyn JC, Driessen SO, de Vries PJ, Cobelens FG, Kager PA, Tropische ziekten en importaandoeningen bij 1763 patiënten op de polikliniek voor Tropische Ziekten van het Academisch Medisch Centrum, Amsterdam (1996-1997). NED TIJDSCHR GENEESKD 2000;144 (45):2152-2156 [PubMed]
Cobelens FG, de Boer HE, Specificiteit van de Mantoux-reactie op het nieuwe tuberculine RT23 ten opzichte van de reactie op het oude PPD-RIVM; vergelijkend onderzoek onder ziekenhuispersoneel. NED TIJDSCHR GENEESKD 1999;143 (16):855-858 [PubMed]
Driessen SO, Cobelens FG, Ligthelm RJ, Travel-related morbidity in travelers with insulin-dependent diabetes mellitus. J TRAVEL MED 1999;6 (1):12-15 [PubMed]
Simons FM, Cobelens FG, Danner SA, Common health problems in HIV-infected travelers to the (sub)tropics. J TRAVEL MED 1999;6 (2):71-75 [PubMed]
Cobelens FG, Yellow fever vaccination and risk of spontaneous abortion. TROP MED INT HEALTH 1998;3 (8):687 [PubMed]
Cobelens FG, Leentvaar-Kuijpers A, Kleijnen J, Coutinho RA, Incidence and risk factors of diarrhoea in Dutch travellers: consequences for priorities in pre-travel health advice. TROP MED INT HEALTH 1998;3 (11):896-903 [PubMed]
Cobelens FG, Verhave JP, Leentvaar-Kuijpers A, Kager PA, Testing for anti-circumsporozoite and anti-blood-stage antibodies for epidemiologic assessment of Plasmodium falciparum infection in travelers. AM J TROP MED HYG 1998;58 (1):75-80 [PubMed]
Cobelens FG, Leentvaar-Kuijpers A, Compliance with malaria chemoprophylaxis and preventative measures against mosquito bites among Dutch travellers. TROP MED INT HEALTH 1997;2 (7):705-713 [PubMed]
Cobelens FG, van Thiel PP, Niet meer klachten bij mefloquinegebruik dan bij malariaprofylaxe met andere middelen. NED TIJDSCHR GENEESKD 1997;141 (16):794-5; author reply 796 [PubMed]
Wetsteyn JC, Cobelens FG, Kager PA, Eggelte TA, Is mefloquine prophylaxis ineffective for short-term travellers?. LANCET 1995;346 (8974):574 [PubMed]
Cobelens F, Needlestick injuries, surgeons, and HIV risks. LANCET 1990;335 (8694):924 [PubMed]
Key publications

Cobelens F, Kik S, Esmail H, Cirillo DM, Lienhardt C, Matteelli A, From latent to patent: rethinking prediction of tuberculosis. LANCET RESP MED 2017;5 (4):243-244 [PubMed]
Durovni B, Saraceni V, van den Hof S, Trajman A, Cordeiro-Santos M, Cavalcante S, Menezes A, Cobelens F, Impact of replacing smear microscopy with Xpert MTB/RIF for diagnosing tuberculosis in Brazil: a stepped-wedge cluster-randomized trial. PLOS MED 2014;11 (12):e1001766 [PubMed]
Cobelens F, van Kampen S, Ochodo E, Atun R, Lienhardt C, Research on Implementation of Interventions in Tuberculosis Control in Low- and Middle-Income Countries: A Systematic Review. PLOS MED 2012;9 (12):e1001358 [PubMed]
Cobelens F, van den Hof S, Pai M, Squire SB, Ramsay A, Kimerling ME [Contributors: Bhan A, Chin D, Dewan P, Durovni B, Dye C, Goldhaber-Fiebert J, Harper I, Langley I, Leeflang M, Lienhardt C, McCray E, Mukadi YD, Nicol M, O'Brien R, Ridderhof J, Schito M, Small P, Vassall A, Zhao Y]] , Which New Diagnostics for Tuberculosis, and When?. J INFECT DIS 2012;205 (2):S191-S198 [PubMed]
Vassall A, van Kampen S, Sohn H, Michael JS, John KR, den Boon S, Davis JL, Whitelaw A, Nicol MP, Gler MT, Khaliqov A, Zamudio C, Perkins MD, Boehme CC, Cobelens F, Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a cost-effectiveness analysis. PLOS MED 2011;8 (11):e1001120 [PubMed]


All Publications

Curriculum Vitae

Prof. Frank Cobelens MD MSc PhD (1959) studied medicine at the University of Amsterdam and communicable disease epidemiology at the London School of Hygiene and Tropical Medicine, and took his PhD at the University of Amsterdam. After having worked for several years in HIV/AIDS control and tropical and travel medicine, he became involved in epidemiological research on tuberculosis in Asia, Africa and Latin America as senior epidemiologist with the Dutch NGO KNCV Tuberculosis Foundation, one of the world’s leading technical agencies for tuberculosis control. Since 2008 he has lead the tuberculosis research group at what later became the Amsterdam Institute for Global Health and Development (AIGHD) and the Department of Global Health of the Academic Medical Center, where he was appointed full professor in 2011. From 2013 through 2015 he combined this position with that of KNCV’s Scientific Director.
He was appointed chair of the Department of Global Health and chair of the Executive Board of AIGHD in January 2016, and has since been leading a large interdisciplinary group of researchers, including epidemiologists, clinical researchers and microbiologists, as well as socials scientists and economists. He remains partially affiliated with KNCV as scientific advisor. Frank Cobelens works closely with research groups around the world, and has supervised numerous junior researchers and doctoral students at home and abroad. His scientific interest is in multidisciplinary approaches to problems at the interface of biomedical aspects of infectious diseases, their socioeconomic context and control policy, combining classical epidemiology with operational research and cost-effectiveness and disease modeling. He has served on numerous global expert panels and advisory bodies, including the World Health Organization’s Strategic and Technical Advisory Group for Tuberculosis.

 


 

Research programmes

Epidemiology and control of poverty-related infectious diseases

This group’s work focuses on the epidemiology and control of tuberculosis (TB) in resource-poor settings, in particular TB-HIV co-infection, anti-TB drug resistance, and new diagnostics. We work closely, through joint affiliations, with KNCV Tuberculosis Foundation (the world’s foremost technical assistance organization in TB control) and the London School of Hygiene and Tropical Medicine, as well as with research institutes in low- and middle-income countries such as South Africa, China, Uganda, Mozambique, Zambia and Brazil and in the USA and elsewhere in Europe. Using a combination of epidemiological, operational and evaluation/impact research, decision-analytical/cost-effectiveness modelling and (in collaboration) transmission modelling, we attempt to fill for each of these the knowledge gap between basic research and development of new interventions on the one hand, and successful implementation of these interventions on the other. This involves establishing the needs and conditions for new interventions (e.g. by studying risk groups and risk factors for infection and disease, associations with M. tuberculosis genotypes), evaluation of such interventions (e.g. diagnostic studies; clinical and community-randomized trials; operational aspects) and assessment of their impact on TB control, health services and costs (field studies, modelling). Since 2008 we have done original work, reviews and policy development around, among other, impact of the HIV epidemic on TB epidemiology; epidemiology of (multi)drug-resistant TB; role of genotype variation in clinical outcomes and drug resistance in Asia and Africa; usefulness, cost-effectiveness and impact on TB control of new diagnostics for latent and active TB; and cost-effectiveness of new treatment modalities. Recently we have started work (empirical as well as modelling) on understanding TB susceptibility, latency, disease progression and disease recurrence; development of the "triage test" concept for TB; and evaluation of new drug regimens for treatment of MDR-TB.

Faculty
Prof. dr. F.G.J. Cobelens MD MSc PhD (Amsterdam Institute for Global Health and Development; KNCV Tuberculosis Foundation)
Dr. G.B. Gomez Guillen (London School of Hygiene & Tropical Medicine)
S. van den Hof PhD (KNCV Tuberculosis Foundation)

Postdocs
Dr. S.M. Hermans MSc PhD
Dr. P. Kapata-Chanda (Department of Disease Surveillance, Control and Research, Ministry of Health, Lusaka, Zambia)

PhD Students
P. Hanson-Nortey
N. Kapata MD MSc (National Tuberculosis Control program, Zambia)
A. Lopez Garcia-Basteiro
S.N. Ng
K. Phommasone
I.T. Spruijt
V. Ssempijja MSc
A.J.W. Wajja

Other research related activities
  • Board of directors / Trustees / Supervisory board, Amsterdam Institute for Global Health and Development
  • (part-time) outside employment, KNCV Tuberculosefonds
  • Board of directors / Trustees / Supervisory board, Health[e] Foundation
  • Membership of medical or scientific committee, BMBF (Bundesministerium für Bildung und Forschung) - Germany, scientific advisory board: Research Networks for Health Innovations in Sub-Saharan Africa
  • Membership of medical or scientific committee, The Union (International Union against Tuberculosis and Lung Disease), scientific advisory board STREAM trial
  • Membership of medical or scientific committee, BMRC (British Medical Research Council), scientific advisory board STAMP trial
  • Contribution to guidelines and protocols, World Health Organization's guidelines for surveillance of drug resistance (2008)
  • Membership of medical or scientific committee, WHO (World Health Organization), Expert committee, line-probe assays for rapid screening for multidrug-resistant tuberculosis (2008)
  • Membership of medical or scientific committee, WHO (World Health Organization), Expert committee, non-commercial culture-based methods for detection of drug-resistant tuberculosis (2009)
  • Contribution to guidelines and protocols, World Health Organization's guidelines on case definitions for surveillance of tuberculosis (2011)
  • Membership of medical or scientific committee, WHO (World Health Organization), Expert committee, automated real-time nucleic acid amplification technology for diagnosis and simultaneous detection of tuberculosis and rifampicin resistance (Xpert MTB/Rif System) (2010, update 2013)
  • Membership of medical or scientific committee, WHO (World Health Organization), Expert committee, use of Delamanid in the treatment of multidrug-resistant tuberculosis (2014)
  • Membership of medical or scientific committee, WHO (World Health Organization), Task Force new tuberculosis drugs and drug regimens (2014-2016)
  • Membership of medical or scientific committee, WHO (World Health Organization), Task Force methods for establishing TB incidence, prevalence and mortality (2015)
  • Membership of medical or scientific committee, WHO (World Health Organization), Task Force new assays for latent tuberculosis infection (since 2015)
  • Contribution to guidelines and protocols, World Health Organization's guidelines on resistance surveillance in tuberculosis (5th ed., 2015)
  • External member, 5-year review committee postgraduate MSc Epidemiology (2015), London School of Hygiene and Tropical Medicine, UK
  • Membership of medical or scientific committee, WHO (World Health Organization), Task Force tuberculosis research policy (since 2016)
Current research funding
  • None reported