• Principal Investigator
  • Female

Dr. A. Boelen

Position: Other
Main activities: Patient care, Research
Specialisation: endocrinology, neonatal screening
foto A. Boelen is one of the AMC Principal Investigators
Focus of research:

Central and peripheral thyroid hormone metabolism during inflammation

Hypothalamus-pituitary-thyroid axis

AMC themes: Metabolic disorders and gastrointestinal diseases
Departments: Clinical Chemistry: Laboratory for Endocrinology, Internal Medicine: Endocrinology
Belegri E, Eggels L, Unmehopa UA, Mul JD, Boelen A, la Fleur SE, The effects of overnight nutrient intake on hypothalamic inflammation in a free-choice diet-induced obesity rat model. APPETITE 2017;ahead of print [PubMed]
Belegri E, Rijnsburger M, Eggels L, Unmehopa U, Scheper W, Boelen A, la Fleur SE, Effects of Fat and Sugar, Either Consumed or Infused toward the Brain, on Hypothalamic ER Stress Markers. FRONT NEUROSCI-SWITZ 2017;11:270 [PubMed]
Blom M, Pico-Knijnenburg I, Sijne-van Veen M, Boelen A, Bredius RGM, van der Burg M, Schielen PCJI, An evaluation of the TREC assay with regard to the integration of SCID screening into the Dutch newborn screening program. CLIN IMMUNOL 2017;180:106-110 [PubMed]
Boelen A, van der Spek AH, Bloise F, de Vries EM, Surovtseva OV, van Beeren M, Ackermans MT, Kwakkel J, Fliers E, Tissue thyroid hormone metabolism is differentially regulated during illness in mice. J ENDOCRINOL 2017;233 (1):25-36 [PubMed]
de Vries EM, Oosterman JE, Eggink HM, de Goede P, Sen S, Foppen E, Boudzovitch-Surovtseva O, Boelen A, Romijn JA, laFleur SE, Kalsbeek A, Effects of meal composition and meal timing on the expression of genes involved in hepatic drug metabolism in rats. PLOS ONE 2017;12 (10):e0185520 [PubMed]
Eggink HM, Oosterman JE, de Goede P, de Vries EM, Foppen E, Koehorst M, Groen AK, Boelen A, Romijn JA, la Fleur SE, Soeters MR, Kalsbeek A, Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats. CHRONOBIOL INT 2017;ahead of print [PubMed]
Eggink HM, van Nierop FS, Schooneman MG, Boelen A, Kalsbeek A, Koehorst M, ten Have GAM, de Brauw LM, Groen AK, Romijn JA, Deutz NEP, Soeters MR, Transhepatic bile acid kinetics in pigs and humans. CLIN NUTR 2017;ahead of print [PubMed]
Glynn N, Kenny H, Quisenberry L, Halsall DJ, Cook P, Kyaw Tun T, McDermott JH, Smith D, Thompson CJ, O'Gorman DJ, Boelen A, Lado-Abeal J, Agha A, The effect of growth hormone replacement on the thyroid axis in patients with hypopituitarism: in vivo and ex vivo studies. CLIN ENDOCRINOL 2017;86 (5):747-754 [PubMed]
Kemper EA, Boelen A, Bosch AM, van Veen-Sijne M, van Rijswijk CN, Bouva MJ, Fingerhut R, Schielen PCJI, Establishing New Cut-Off Limits for Galactose 1-Phosphate-Uridyltransferase Deficiency for the Dutch Newborn Screening Programme. JIMD REPORTS 2017;32:1-6 [PubMed]
van der Spek AH, Fliers E, Boelen A, The classic pathways of thyroid hormone metabolism. MOL CELL ENDOCRINOL 2017;ahead of print [PubMed]
van der Spek AH, Fliers E, Boelen A, Thyroid hormone metabolism in innate immune cells. J ENDOCRINOL 2017;232 (2):R67-R81 [PubMed]
van der Spek AH, Surovtseva OV, Aan S, Tool ATJ, van de Geer A, Demir K, van Gucht ALM, van Trotsenburg ASP, van den Berg TK, Fliers E, Boelen A, Increased circulating interleukin-8 in patients with resistance to thyroid hormone receptor α. ENDOCR CONNECT 2017;6 (8):731-740 [PubMed]
Welling L, Boelen A, Derks TGJ, Schielen PCJI, de Vries M, Williams M, Wijburg FA, Bosch AM, Nine years of newborn screening for classical galactosemia in the Netherlands: Effectiveness of screening methods, and identification of patients with previously unreported phenotypes. MOL GENET METAB 2017;120 (3):223-228 [PubMed]
Williams FLR, Ogston S, Hume R, Watson J, Stanbury K, Willatts P, Boelen A, Juszczak E, Brocklehurst P, Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: An RCT. PEDIATRICS 2017;139 (5):e20163703 [PubMed]
Williams FLR, Watson J, Day C, Soe A, Somisetty SK, Jackson L, Velten E, Boelen A, Thyroid dysfunction in preterm neonates exposed to iodine. J PERINAT MED 2017;45 (1):135-143 [PubMed]
Zhang Z. Hypothalamic regulation of metabolism: Role of thyroid hormone and estrogen. S.l.: s.n.; 2017. 164p. ISBN 978-94-6332-112-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Kalsbeek A; copromotor(s): Bisschop PHLT, Boelen A)
Zhang Z, Boelen A, Bisschop PH, Kalsbeek A, Fliers E, Hypothalamic effects of thyroid hormone. MOL CELL ENDOCRINOL 2017;ahead of print [PubMed]
Bloise FF, van der Spek AH, Surovtseva OV, Ortiga-Carvalho TM, Fliers E, Boelen A, Differential Effects of Sepsis and Chronic Inflammation on Diaphragm Muscle Fiber Type, Thyroid Hormone Metabolism, and Mitochondrial Function. THYROID 2016;26 (4):600-609 [PubMed]
Boelen A, Ruiter AFC, Claahsen-van der Grinten HL, Endert E, Ackermans MT, Determination of a steroid profile in heel prick blood using LC-MS/MS. BIOANALYSIS 2016;8 (5):375-384 [PubMed]
de Vries EM, Lammers LA, Achterbergh R, Klümpen HJ, Mathot RAA, Boelen A, Romijn JA, Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR. PLOS ONE 2016;11 (7):e0159552 [PubMed]
de Vries EM, Nagel S, Haenold R, Sundaram SM, Pfrieger FW, Fliers E, Heuer H, Boelen A, The Role of Hypothalamic NF-κB Signaling in the Response of the HPT-Axis to Acute Inflammation in Female Mice. ENDOCRINOLOGY 2016;157 (7):2947-2956 [PubMed]
Heinen CA, Jongejan A, Watson PJ, Redeker B, Boelen A, Boudzovitch-Surovtseva O, Forzano F, Hordijk R, Kelley R, Olney AH, Pierpont ME, Schaefer GB, Stewart F, van Trotsenburg ASP, Fliers E, Schwabe JWR, Hennekam RC, A specific mutation in TBL1XR1 causes Pierpont syndrome. J MED GENET 2016;53 (5):330-337 [PubMed]
Heinen CA, Losekoot M, Sun Y, Watson PJ, Fairall L, Joustra SD, Zwaveling-Soonawala N, Oostdijk W, van den Akker ELT, Alders M, Santen GWE, van Rijn RR, Dreschler WA, Surovtseva OV, Biermasz NR, Hennekam RC, Wit JM, Schwabe JWR, Boelen A, Fliers E, van Trotsenburg ASP, Mutations in TBL1X Are Associated With Central Hypothyroidism. J CLIN ENDOCR METAB 2016;101 (12):4564-4573 [PubMed]
Lammers LA, Achterbergh R, Pistorius MCM, Bijleveld Y, de Vries EM, Boelen A, Klümpen HJ, Romijn JA, Mathôt RAA, Quantitative Method for Simultaneous Analysis of a 5-Probe Cocktail for Cytochrome P450 Enzymes. THER DRUG MONIT 2016;38 (6):761-768 [PubMed]
Rijnsburger M, Belegri E, Eggels L, Unmehopa UA, Boelen A, Serlie MJ, la Fleur SE, The effect of diet interventions on hypothalamic nutrient sensing pathways in rodents. PHYSIOL BEHAV 2016;162:61-68 [PubMed]
van der Spek AH, Bloise FF, Tigchelaar W, Dentice M, Salvatore D, van der Wel NN, Fliers E, Boelen A, The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils. ENDOCRINOLOGY 2016;157 (8):3293-3305 [PubMed]
Visser WE, Bombardieri CR, Zevenbergen C, Barnhoorn S, Ottaviani A, van der Pluijm I, Brandt R, Kaptein E, van Heerebeek R, van Toor H, Garinis GA, Peeters RP, Medici M, van Ham W, Vermeij WP, de Waard MC, de Krijger RR, Boelen A, Kwakkel J, Kopchick JJ, List EO, Melis JPM, Darras VM, Dollé MET, van der Horst GTJ, Hoeijmakers JHJ, Visser TJ, Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging. PLOS ONE 2016;11 (3):e0149941 [PubMed]
Zhang Z, Bisschop PH, Foppen E, van Beeren HC, Kalsbeek A, Boelen A, Fliers E, A model for chronic, intrahypothalamic thyroid hormone administration in rats. J ENDOCRINOL 2016;229 (1):37-45 [PubMed]
Zhang Z, Foppen E, Su Y, Bisschop PH, Kalsbeek A, Fliers E, Boelen A, Metabolic Effects of Chronic T3 Administration in the Hypothalamic Paraventricular and Ventromedial Nucleus in Male Rats. ENDOCRINOLOGY 2016;157 (10):4076-4085 [PubMed]
Zhang Z, Liu J, Veldhuis-Vlug AG, Su Y, Foppen E, van der Eerden BCJ, Koedam M, Bravenboer N, Kalsbeek A, Boelen A, Fliers E, Bisschop PH, Effects of Chronic Estrogen Administration in the Ventromedial Nucleus of the Hypothalamus (VMH) on Fat and Bone Metabolism in Ovariectomized Rats. ENDOCRINOLOGY 2016;157 (12):4930-4942 [PubMed]
Bassett JHD, van der Spek A, Logan JG, Gogakos A, Bagchi-Chakraborty J, Murphy E, van Zeijl C, Down J, Croucher PI, Boyde A, Boelen A, Williams GR, Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development. ENDOCRINOLOGY 2015;156 (9):3098-3113 [PubMed]
de Vries EM. Thyroid hormone metabolism during inflammation and fasting. S.l.: s.n.; 2015. 187p. ISBN 978-94-6259-597-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Kalsbeek A; copromotor(s): Boelen A)
de Vries EM, Fliers E, Boelen A, The molecular basis of the non-thyroidal illness syndrome. J ENDOCRINOL 2015;225 (3):R67-R81 [PubMed]
de Vries EM, van Beeren HC, Ackermans MT, Kalsbeek A, Fliers E, Boelen A, Differential effects of fasting vs food restriction on liver thyroid hormone metabolism in male rats. J ENDOCRINOL 2015;224 (1):25-35 [PubMed]
Fliers E, Bianco AC, Langouche L, Boelen A, Thyroid function in critically ill patients. LANCET DIABETES ENDO 2015;3 (10):816-825 [PubMed]
Lammers LA, Achterbergh R, de Vries EM, van Nierop FS, Klümpen HJ, Soeters MR, Boelen A, Romijn JA, Mathôt RAA, Short-term fasting alters cytochrome P450-mediated drug metabolism in humans. DRUG METAB DISPOS 2015;43 (6):819-828 [PubMed]
Salloum-Asfar S, Boelen A, Reitsma PH, van Vlijmen BJM, The immediate and late effects of thyroid hormone (triiodothyronine) on murine coagulation gene transcription. PLOS ONE 2015;10 (5):e0127469 [PubMed]
de Vries EM, Eggels L, van Beeren HC, Ackermans MT, Kalsbeek A, Fliers E, Boelen A, Fasting-induced changes in hepatic thyroid hormone metabolism in male rats are independent of autonomic nervous input to the liver. ENDOCRINOLOGY 2014;155 (12):5033-5041 [PubMed]
de Vries EM, Kwakkel J, Eggels L, Kalsbeek A, Barrett P, Fliers E, Boelen A, NF kappa B Signaling Is Essential for the Lipopolysaccharide-Induced Increase of Type 2 Deiodinase in Tanycytes. ENDOCRINOLOGY 2014;155 (5):2000-2008 [PubMed]
Fliers E, Boelen A, van Trotsenburg ASP. Central regulation of the hypothalamo-pituitary-thyroid (HPT) axis: focus on clinical aspects in: Fliers E, Korbonits M, Romijn JA, editors. Handbook of Clinical Neurology Vol.124. Toronto: Elsevier; 2014. Chapter 9, p. 127-138
Fliers E, Boelen A, van Trotsenburg ASP, Central regulation of the hypothalamo-pituitary-thyroid (HPT) axis: focus on clinical aspects. HANDB CLIN NEUROL 2014;124:127-138 [PubMed]
Fliers E, Kalsbeek A, Boelen A, Beyond the fixed setpoint of the hypothalamus-pituitary-thyroid axis. EUR J ENDOCRINOL 2014;171 (5):R197-R208 [PubMed]
Herwig A, Campbell G, Mayer CD, Boelen A, Anderson RA, Ross AW, Mercer JG, Barrett P, A thyroid hormone challenge in hypothyroid rats identifies t3 regulated genes in the hypothalamus and in models with altered energy balance and glucose homeostasis. THYROID 2014;24 (11):1575-1593 [PubMed]
Kwakkel J, Surovtseva OV, de Vries EM, Stap J, Fliers E, Boelen A, A Novel Role for the Thyroid Hormone-Activating Enzyme Type 2 Deiodinase in the Inflammatory Response of Macrophages. ENDOCRINOLOGY 2014;155 (7):2725-2734 [PubMed]
Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H, Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. J CLIN INVEST 2014;124 (5):1987-1999 [PubMed]
Müller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H, Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency. ENDOCRINOLOGY 2014;155 (1):315-325 [PubMed]
van Zeijl CJJ, Surovtseva OV, Kwakkel J, van Beeren HC, Duncan Bassett JH, Williams GR, Wiersinga WM, Fliers E, Boelen A, Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness. AM J PHYSIOL-ENDOC M 2014;307 (6):E527-E537 [PubMed]
Bisschop PH, Dekker MJHJ, Osterthun W, Kwakkel J, Anink JJ, Boelen A, Unmehopa UA, Koper JW, Lamberts SWJ, Stewart PM, Swaab DF, Fliers E, Expression of 11β-hydroxysteroid dehydrogenase type 1 in the human hypothalamus. J NEUROENDOCRINOL 2013;25 (5):425-432 [PubMed]
Boelen A, van Veen M, Verkerk PH, Diependaal G, Loeber G, Elvers B, Endert E, Measuring free thyroxine levels in neonatal heel-prick samples. CLIN CHIM ACTA 2013;423:51-55 [PubMed]
Langouche L, Vander Perre S, Marques M, Boelen A, Wouters PJ, Casaer MP, van den Berghe G, Impact of Early Nutrient Restriction During Critical Illness on the Nonthyroidal Illness Syndrome and Its Relation With Outcome: A Randomized, Controlled Clinical Study. J CLIN ENDOCR METAB 2013;98 (3):1006-1013 [PubMed]
Varewijck AJ, Boelen A, Lamberts SWJ, Fliers E, Hofland LJ, Wiersinga WM, Janssen JAMJL, Circulating IgGs May Modulate IGF-I Receptor Stimulating Activity in a Subset of Patients With Graves' Ophthalmopathy. J CLIN ENDOCR METAB 2013;98 (2):769-776 [PubMed]
Ackermans MT, Kettelarij-Haas Y, Boelen A, Endert E, Determination of thyroid hormones and their metabolites in tissue using SPE UPLC-tandem MS. BIOMED CHROMATOGR 2012;26 (4):485-490 [PubMed]
Boelen A, Kwakkel J, Fliers E, Thyroid hormone receptors in health and disease. MINERVA ENDOCRINOL 2012;37 (4):291-303 [PubMed]
Boelen A, van Beeren M, Vos X, Surovtseva O, Belegri E, Saaltink DJ, Vreugdenhil E, Kalsbeek A, Kwakkel J, Fliers E, Leptin Administration Restores the Fasting-Induced Increase of Hepatic Type 3 Deiodinase Expression in Mice. THYROID 2012;22 (2):192-199 [PubMed]
Louwerens M, Appelhof BC, Verloop H, Medici M, Peeters RP, Visser TJ, Boelen A, Fliers E, Smit JWA, Dekkers OM, Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism. EUR J ENDOCRINOL 2012;167 (6):809-815 [PubMed]
van Beeren HC, Kwakkel J, Ackermans MT, Wiersinga WM, Fliers E, Boelen A, Action of Specific Thyroid Hormone Receptor alpha(1) and beta(1) Antagonists in the Central and Peripheral Regulation of Thyroid Hormone Metabolism in the Rat. THYROID 2012;22 (12):1275-1282 [PubMed]
van Zeijl CJJ, van Koppen CJ, Surovtseva OV, de Gooyer ME, Plate R, Conti P, Karstens WJ, Timmers M, Saeed P, Wiersinga WM, Miltenburg AMM, Fliers E, Boelen A, Complete Inhibition of rhTSH-, Graves' Disease IgG-, and M22-Induced cAMP Production in Differentiated Orbital Fibroblasts by a Low-Molecular-Weight TSHR Antagonist. J CLIN ENDOCR METAB 2012;97 (5):E781-E785 [PubMed]
Boelen A, Endert E. Werkingsmechanismen Hormonen in: Schellekens APM, editor. Endocrinologie voor analisten. Utrecht: Syntax Media; 2011. Hoofdstuk 2, p. 19-30
Boelen A, Kwakkel J, Fliers E, Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. ENDOCR REV 2011;32 (5):670-693 [PubMed]
Kwakkel J, Fliers E, Boelen A, Illness-induced changes in thyroid hormone metabolism: focus on the tissue level. NETH J MED 2011;69 (5):224-228 [PubMed]
Soeters MR, van Zeijl CJJ, Boelen A, Kloos R, Saeed P, Vriesendorp TM, Mourits MP, Optimal management of Graves orbitopathy: a multidisciplinary approach. NETH J MED 2011;69 (7):302-308 [PubMed]
van Zeijl CJJ. Nonclassical ligands for the thyrotropin receptor. Functional studies on thyrostimulin and Graves' disease immunoglobulins. s.l.: s.n.; 2011. 189p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Wiersinga WM; copromotor(s): Boelen A, van Koppen CJ)
van Zeijl CJJ, Fliers E, van Koppen CJ, Surovtseva OV, de Gooyer ME, Mourits MP, Wiersinga WM, Miltenburg AMM, Boelen A, Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways. THYROID 2011;21 (2):169-176 [PubMed]
van Zeijl CJJ, Surovtseva OV, Wiersinga WM, Fliers E, Boelen A, Acute Inflammation Increases Pituitary and Hypothalamic Glycoprotein Hormone Subunit B5 mRNA Expression in Association with Decreased Thyrotrophin Receptor mRNA Expression in Mice. J NEUROENDOCRINOL 2011;23 (4):310-319 [PubMed]
Fliers E, Boelen A, Type 2 Deiodinase and Brown Fat: The Heat Is On--or Off. ENDOCRINOLOGY 2010;151 (9):4087-4089 [PubMed]
Kwakkel GJ. Understanding the non-thyroidal illness syndrome frrom in vivo and iin vitro studies. s.l.: s.n.; 2010. 189p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Wiersinga WM, Fliers E; copromotor(s): Boelen A)
Kwakkel J, Chassande O, van Beeren HC, Fliers E, Wiersinga WM, Boelen A, Thyroid Hormone Receptor alpha Modulates Lipopolysaccharide-Induced Changes in Peripheral Thyroid Hormone Metabolism. ENDOCRINOLOGY 2010;151 (4):1959-1969 [PubMed]
van Zeijl CJJ, Fliers E, van Koppen CJ, Surovtseva OV, de Gooyer ME, Mourits MP, Wiersinga WM, Miltenburg AMM, Boelen A, Effects of Thyrotropin and Thyrotropin-Receptor-Stimulating Graves' Disease Immunoglobulin G on Cyclic Adenosine Monophosphate and Hyaluronan Production in Nondifferentiated Orbital Fibroblasts of Graves' Ophthalmopathy Patients. THYROID 2010;20 (5):535-244 [PubMed]
van Zeijl CJJ, Surovtseva OV, Wiersinga WM, Boelen A, Fliers E, Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice. MOL CELL ENDOCRINOL 2010;321 (2):231-238 [PubMed]
Boelen A, Thyroid hormones and glucose metabolism: the story begins before birth. EXP PHYSIOL 2009;94 (10):1050-1051 [PubMed]
Boelen A, Kwakkel J, Chassande O, Fliers E, Thyroid Hormone Receptor beta Mediates Acute Illness-Induced Alterations in Central Thyroid Hormone Metabolism. J NEUROENDOCRINOL 2009;21 (5):465-472 [PubMed]
Boelen A, Kwakkel J, Wieland CW, St Germain DL, Fliers E, Hernandez A, Impaired bacterial clearance in type 3 deiodinase deficient mice infected with Streptococcus pneumoniae. ENDOCRINOLOGY 2009;150 (4):1984-1990 [PubMed]
Boelen A, Mikita J, Boiziau C, Chassande O, Fliers E, Petry KG, Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis. THYROID 2009;19 (12):1401-1406 [PubMed]
Herwig A, Wilson D, Logie TJ, Boelen A, Morgan PJ, Mercer JG, Barrett P, Photoperiod and acute energy deficits interact on components of the thyroid hormone system in hypothalamic tanycytes of the Siberian hamster. AM J PHYSIOL-REG I 2009;296 (5):R1307-R1315 [PubMed]
Klieverik LP, Janssen SF, van Riel A, Foppen E, Bisschop PH, Serlie MJ, Boelen A, Ackermans MT, Sauerwein HP, Fliers E, Kalsbeek A, Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. P NATL ACAD SCI USA 2009;106 (14):5966-5971 [PubMed]
Kwakkel J, van Beeren HC, Ackermans MT, Platvoet-ter Schiphorst MC, Fliers E, Wiersinga WM, Boelen A, Skeletal muscle deiodinase type 2 regulation during illness in mice. J ENDOCRINOL 2009;203 (2):263-270 [PubMed]
Boelen A, Boorsma J, Kwakkel J, Wieland CW, Renckens R, Visser TJ, Fliers E, Wiersinga WM, Type 3 Deiodinase Is Highly Expressed in Infiltrating Neutrophilic Granulocytes in Response to Acute Bacterial Infection. THYROID 2008;18 (10):1095-1103 [PubMed]
Boelen A, Wiersinga WM, Fliers E, Fasting-induced changes in the hypothalamus-pituitary-thyroid axis. THYROID 2008;18 (2):123-129 [PubMed]
Klieverik LP, Sauerwein HP, Ackermans MT, Boelen A, Kalsbeek A, Fliers E, Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. AM J PHYSIOL-ENDOC M 2008;294 (3):E513-E520 [PubMed]
Kwakkel J, Chassande O, van Beeren HC, Wiersinga WM, Boelen A, Lacking thyroid hormone receptor beta gene does not influence alterations in peripheral thyroid hormone metabolism during acute illness. J ENDOCRINOL 2008;197 (1):151-158 [PubMed]
Barrett P, Ebling FJP, Schuhler S, Wilson D, Ross AW, Warner A, Jethwa P, Boelen A, Visser TJ, Ozanne DM, Archer ZA, Mercer JG, Morgan PJ, Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction. ENDOCRINOLOGY 2007;148 (8):3608-3617 [PubMed]
Boelen A. Screening op congenitale bijnierschorshyperplasie in: Krenning EP, Wiersinga WM, Lamberts SWJ, Nobels F, Bouillon R, editors. Endocrinologie. S.l.: Elsevier Gezondheidszorg; 2007., p. 93
Kwakkel J, Wiersinga WM, Boelen A, Interleukin-1 beta modulates endogenous thyroid hormone receptor alpha gene transcription in liver cells. J ENDOCRINOL 2007;194 (2):257-265 [PubMed]
ten Hoedt AE, van Kempen AA, Boelen A, Duran M, Kemper-Proper EA, Oey-Spauwen MJW, Wijburg FA, Bosch AM, High incidence of hypermethioninaemia in a single neonatal intensive care unit detected by a newly introduced neonatal screening programme. J INHERIT METAB DIS 2007;30 (6):978 [PubMed]
Boelen A, Kwakkel J, Vos XG, Wiersinga WM, Fliers E, Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor beta2 mRNA expression in mice. J ENDOCRINOL 2006;190 (2):537-544 [PubMed]
Boelen A, Kwakkel J, Wiersinga WM, Fliers E, Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake. J ENDOCRINOL 2006;191 (3):707-714 [PubMed]
Boelen A, Wiersinga WM, Koehrle J, Contributions of cytokines to nonthyroidal illness. CURR OPIN ENDOCRINOL DIABETES 2006;13:444-450
Kwakkel J, Wiersinga WM, Boelen A, Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA. J ENDOCRINOL 2006;189 (1):37-44 [PubMed]
Boelen A, Kwakkel J, Alkemade A, Renckens R, Kaptein E, Kuiper G, Wiersinga WM, Visser TJ, Induction of type 3 deiodinase activity in inflammatory cells of mice with chronic local inflammation. ENDOCRINOLOGY 2005;146 (12):5128-5134 [PubMed]
Barends M, de Rond LGH, Dormans J, van Oosten M, Boelen A, Neijens HJ, Osterhaus ADME, Kimman TG, Respiratory syncytial virus, pneumonia virus of mice, and influenza A virus differently affect respiratory allergy in mice. CLIN EXP ALLERGY 2004;34 (3):488-496 [PubMed]
Boelen A, Kwakkel J, Platvoet-ter Schiphorst M, Baur A, Köhrle J, Wiersinga WM, Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness. HORM METAB RES 2004;36 (2):101-106 [PubMed]
Boelen A, Kwakkel J, Platvoet-ter Schiphorst M, Mentrup B, Baur A, Koehrle J, Wiersinga WM, Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis. EUR J ENDOCRINOL 2004;151 (4):497-502 [PubMed]
Boelen A, Kwakkel J, Thijssen-Timmer DC, Alkemade A, Fliers E, Wiersinga WM, Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice. J ENDOCRINOL 2004;182 (2):315-323 [PubMed]
Barends M, Boelen A, de Rond L, Dormans J, Kwakkel J, van Oosten M, Neijens HJ, Kimman TG, Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-gamma. J MED VIROL 2003;69 (1):156-162 [PubMed]
Barends M, Boelen A, de Rond L, Kwakkel J, Bestebroer T, Dormans J, Neijens H, Kimman T, Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice. CLIN EXP ALLERGY 2002;32 (3):463-471 [PubMed]
Boelen A, Kwakkel J, Barends M, de Rond L, Dormans J, Kimman T, Effect of lack of Interleukin-4, Interleukin-12, Interleukin-18, or the Interferon-gamma receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice. J MED VIROL 2002;66 (4):552-560 [PubMed]
Boelen A, Andeweg A, Kwakkel J, Lokhorst W, Bestebroer T, Dormans J, Kimman T, Both immunisation with a formalin-inactivated respiratory syncytial virus (RSV) vaccine and a mock antigen vaccine induce severe lung pathology and a Th2 cytokine profile in RSV-challenged mice. VACCINE 2000;19 (7-8):982-991 [PubMed]
Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM, Immunoneutralization of interleukin-1, tumor necrosis factor, interleukin-6 or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice. J ENDOCRINOL 1997;153 (1):115-122 [PubMed]
Boelen A, Maas MA, Lowik CW, Platvoet MC, Wiersinga WM, Induced illness in interleukin-6 (IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3'-triiodothyronine syndrome. ENDOCRINOLOGY 1996;137 (12):5250-5254 [PubMed]
Boelen A, Platvoet-ter Schiphorst MC, van Rooijen N, Wiersinga WM, Selective macrophage depletion in the liver does not prevent the development of the sick euthyroid syndrome in the mouse. EUR J ENDOCRINOL 1996;134 (4):513-518 [PubMed]
Boelen A, Schiphorst MC, Wiersinga WM, Relationship between serum 3,5,3'-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness. J ENDOCRINOL INVEST 1996;19 (7):480-483 [PubMed]
Boelen A, Platvoet-ter Schiphorst MC, Bakker O, Wiersinga WM, The role of cytokines in the lipopolysaccharide-induced sick euthyroid syndrome in mice. J ENDOCRINOL 1995;146 (3):475-483 [PubMed]
Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM, Soluble cytokine receptors and the low 3,5,3'-triiodothyronine syndrome in patients with nonthyroidal disease. J CLIN ENDOCR METAB 1995;80 (3):971-976 [PubMed]
DeRijk RH, Boelen A, Tilders FJ, Berkenbosch F, Induction of plasma interleukin-6 by circulating adrenaline in the rat. PSYCHONEUROENDOCRINO 1994;19 (2):155-163 [PubMed]
Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM, Association between serum interleukin-6 and serum 3,5,3'-triiodothyronine in nonthyroidal illness. J CLIN ENDOCR METAB 1993;77 (6):1695-1699 [PubMed]
Key publications

van der Spek AH, Bloise FF, Tigchelaar W, Dentice M, Salvatore D, van der Wel NN, Fliers E, Boelen A, The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils. ENDOCRINOLOGY 2016;157 (8):3293-3305 [PubMed]
Heinen CA, Losekoot M, Sun Y, Watson PJ, Fairall L, Joustra SD, Zwaveling-Soonawala N, Oostdijk W, van den Akker ELT, Alders M, Santen GWE, van Rijn RR, Dreschler WA, Surovtseva OV, Biermasz NR, Hennekam RC, Wit JM, Schwabe JWR, Boelen A, Fliers E, van Trotsenburg ASP, Mutations in TBL1X Are Associated With Central Hypothyroidism. J CLIN ENDOCR METAB 2016;101 (12):4564-4573 [PubMed]
Fliers E, Bianco AC, Langouche L, Boelen A, Thyroid function in critically ill patients. LANCET DIABETES ENDO 2015;3 (10):816-825 [PubMed]
Kwakkel J, Surovtseva OV, de Vries EM, Stap J, Fliers E, Boelen A, A Novel Role for the Thyroid Hormone-Activating Enzyme Type 2 Deiodinase in the Inflammatory Response of Macrophages. ENDOCRINOLOGY 2014;155 (7):2725-2734 [PubMed]
Boelen A, Kwakkel J, Fliers E, Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. ENDOCR REV 2011;32 (5):670-693 [PubMed]


All Publications

Research programmes

Thyroid hormone metabolism and action

 My research focusses on thyroid hormone (TH) metabolism during illness and on mechanisms involved in congenital central hypothyroidism. We focus on the newly discovered role of cellular TH metabolism in macrophages and neutrophils during the inflammatory response and translate findings to the clinical setting to improve treatment of sepsis. Another goal is to study two recently found mutations in genes associated with central congenital hypothyroidism.

Faculty
Dr. A. Boelen

Postdocs
Dr. E.M. de Vries

PhD Students
E. Belegri MSc
Drs. H.M. Eggink
C.A. Heinen
Drs. J.C. Naafs
Drs. A.H. van der Spek
Drs. K. Stroek MSc

Others
Dr. H.C. van Beeren
Ing. O.V. Surovtseva

Prof. dr. E. Fliers (Neuroendocrinology)

Other research related activities
  • Membership of medical or scientific committee, European Thyroid Association, educational board
  • Membership of medical or scientific committee, Dutch Endocrine Society, board
  • Membership of medical or scientific committee, Dutch Thyroid Association, secretary board
  • Membership of advisory board / Consultant, Advies Commissie Neonatale sceening CH-AGS
  • Membership of editorial board / Editorship, JOURNAL OF ENDOCRINOLOGY
  • Membership of editorial board / Editorship, ENDOCRINOLOGY
  • Membership of medical or scientific committee, Other, Program Organizing Committee ITC2020
Current research funding
  • AMC
  • Innovatiefonds Zorgverzekeraars
  • Medical Research BV
  • PerkinElmer