• Principal Investigator
  • Male

Dr. D. Amsen

Position: Scientific staff member (UD)
Main activities: Research
Specialisation: Immunology/regulation of transcription
foto D. Amsen is one of the AMC Principal Investigators
Focus of research:
AMC themes: Infection & Immunity
Departments: Landsteiner Laboratory
Amsen D, T cells take directions from supporting cast in graft-versus-host disease. J CLIN INVEST 2017;127 (4):1215-1217 [PubMed]
Amsen D, Hombrink P, van Lier RAW, Tumor immunity requires border patrol to fight the enemy within. NAT IMMUNOL 2017;18 (8):870-872 [PubMed]
Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, Brasser G, Jongejan A, Jonkers RE, Nota B, Basak O, Clevers HC, Moerland PD, Amsen D, van Lier RAW, Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells (vol 17, pg 1467, 2016). NAT IMMUNOL 2017;18 (2):246 [PubMed]
Kleinjan A, Tindemans I, Montgomery JE, Lukkes M, de Bruijn MJW, van Nimwegen M, Bergen I, Moellering RE, Hoogsteden HC, Boon L, Amsen D, Hendriks RW, The Notch Pathway Inhibitor SAHM1 Abrogates the Hallmarks of Allergic Asthma. J ALLERGY CLIN IMMUN 2017;ahead of print [PubMed]
Oja AE, Piet B, Helbig C, Stark R, van der Zwan D, Blaauwgeers H, Remmerswaal EBM, Amsen D, Jonkers RE, Moerland PD, Nolte MA, van Lier RAW, Hombrink P, Trigger-happy resident memory CD4(+) T cells inhabit the human lungs. MUCOSAL IMMUNOL 2017;ahead of print [PubMed]
Tindemans I, Lukkes M, de Bruijn MJW, Li BWS, van Nimwegen M, Amsen D, Kleinjan A, Hendriks RW, Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable. J ALLERGY CLIN IMMUN 2017;140 (4):1079-1089 [PubMed]
Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, Brasser G, Jongejan A, Jonkers RE, Nota B, Basak O, Clevers HC, Moerland PD, Amsen D, van Lier RAW, Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. NAT IMMUNOL 2016;17 (12):1467-1478 [PubMed]
Amsen D, Helbig C, Backer RA, Notch in T Cell Differentiation: All Things Considered. TRENDS IMMUNOL 2015;36 (12):802-814 [PubMed]
Helbig C, Amsen D, Notch Signaling: Piercing a Harness of Simplicity. IMMUNITY 2015;43 (5):831-833 [PubMed]
Neumann K, Rudolph C, Neumann C, Janke M, Amsen D, Scheffold A, Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway. EUR J IMMUNOL 2015;45 (7):2008-2016 [PubMed]
Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AHC, Kaech SM, Blander JM, van Gisbergen K, Amsen D, A central role for Notch in effector CD8(+) T cell differentiation. NAT IMMUNOL 2014;15 (12):1143-1151 [PubMed]
Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM, TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation. CELL 2014;158 (3):506-521 [PubMed]
Amsen D, Backer RA, Helbig C, Decisions on the Road to Memory. ADV EXP MED BIOL 2013;785:107-120 [PubMed]
Gentek R. Mechanisms of Notch signaling specifity in lymphocytes and their leukemic counterparts. s.l.: s.n.; 2013. 230p. ISBN 9789461823908 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Spits H; copromotor(s): Amsen D)
Gentek R, Munneke JM, Helbig C, Blom B, Hazenberg MD, Spits H, Amsen D, Modulation of signal strength switches Notch from an inducer of T cells to an inducer of ILC2. FRONT IMMUNOL 2013;4:UNSP 334 [PubMed]
Helbig C. How Notch and Wnt make T-cells tick. s.l.: s.n.; 2013. 150p. ISBN 9789461822253 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kapsenberg ML; copromotor(s): Amsen D)
Helbig C, Gentek R, Backer RA, de Souza Y, Derks IAM, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D, Notch controls the magnitude of T helper cell responses by promoting cellular longevity. P NATL ACAD SCI USA 2012;109 (23):9041-9046 [PubMed]
Karrich JJ, Balzarolo M, Schmidlin H, Libouban M, Nagasawa M, Gentek R, Kamihira S, Maeda T, Amsen D, Wolkers MC, Blom B, The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1. BLOOD 2012;119 (22):5191-5200 [PubMed]
Nair P, Amsen D, Blander JM, Co-ordination of incoming and outgoing traffic in antigen-presenting cells by pattern recognition receptors and T cells. TRAFFIC 2011;12 (12):1669-1676 [PubMed]
Sander LE, Davis MJ, Boekschoten MV, Amsen D, Dascher CC, Ryffel B, Swanson JA, Müller M, Blander JM, Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. NATURE 2011;474 (7351):385-389 [PubMed]
Amsen D, Antov A, Flavell RA, The different faces of Notch in T-helper-cell differentiation. NAT REV IMMUNOL 2009;9 (2):116-124 [PubMed]
Amsen D, de Visser KE, Town T, Approaches to determine expression of inflammatory cytokines. METHODS MOL BIOL 2009;511:107-142 [PubMed]
Amsen D, Spilianakis CG, Flavell RA, How are T(H)1 and T(H)2 effector cells made?. CURR OPIN IMMUNOL 2009;21 (2):153-160 [PubMed]
Antov A. Importance of Notch and Wnt pathways for Th2 cells. USA: s.n.; 2009. 161p. Proefschrift Yale, School of medicine, Dept. of Immunobiology. (Promotor(s): Flavell RA; copromotor(s): Amsen D)
Blander JM, Amsen D, Immunology. Amino acid addiction. SCIENCE 2009;324 (5932):1282-1283 [PubMed]
Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA, Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. IMMUNITY 2007;27 (1):89-99 [PubMed]
Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA, Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. CELL 2004;117 (4):515-526 [PubMed]
Amsen D, Kruisbeek A, Bos JL, Reedquist K, Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection. EUR J IMMUNOL 2000;30 (10):2832-2841 [PubMed]
Amsen D, Revilla Calvo C, Osborne BA, Kruisbeek AM, Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes. P NATL ACAD SCI USA 1999;96 (2):622-627 [PubMed]
Amsen D, Kruisbeek AM, Thymocyte selection: not by TCR alone. IMMUNOL REV 1998;165:209-229 [PubMed]
Gravestein LA, Amsen D, Boes M, Calvo CR, Kruisbeek AM, Borst J, The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. EUR J IMMUNOL 1998;28 (7):2208-2216 [PubMed]
Calvo CR, Amsen D, Kruisbeek AM, Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. J EXP MED 1997;186 (10):1645-1653 [PubMed]
Amsen D, Kruisbeek AM, CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytes. INT IMMUNOL 1996;8 (12):1927-1936 [PubMed]
Kruisbeek AM, Amsen D, Mechanisms underlying T-cell tolerance. CURR OPIN IMMUNOL 1996;8 (2):233-244 [PubMed]
Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M, E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. CELL 1994;79 (5):885-892 [PubMed]
Key publications

Helbig C, Gentek R, Backer RA, de Souza Y, Derks IAM, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D, Notch controls the magnitude of T helper cell responses by promoting cellular longevity. P NATL ACAD SCI USA 2012;109 (23):9041-9046 [PubMed]
Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AHC, Kaech SM, Blander JM, van Gisbergen K, Amsen D, A central role for Notch in effector CD8(+) T cell differentiation. NAT IMMUNOL 2014;15 (12):1143-1151 [PubMed]
Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, Brasser G, Jongejan A, Jonkers RE, Nota B, Basak O, Clevers HC, Moerland PD, Amsen D, van Lier RAW, Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. NAT IMMUNOL 2016;17 (12):1467-1478 [PubMed]
Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM, TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation. CELL 2014;158 (3):506-521 [PubMed]
Sander LE, Davis MJ, Boekschoten MV, Amsen D, Dascher CC, Ryffel B, Swanson JA, Müller M, Blander JM, Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. NATURE 2011;474 (7351):385-389 [PubMed]


All Publications

Research programmes

T cells for adoptive cellular therapy: fundaments and therapeutic application

Faculty
Dr. D. Amsen (Sanquin)

Postdocs
Dr. R.A. Backer
Dr. E. Cuadrado (Sanquin)
Dr. C. Helbig (Sanquin)
Dr. J. Karrich

PhD Students
R. Opstelten
Drs. W. Huisman (LUMC)

Others
M. Slot BSc (Sanquin)

Other research related activities
  • None reported
Current research funding
  • None reported