• Principal Investigator
  • Male

Prof. D. van de Beek MD PhD

Position: Professor
Main activities: Patient care, Research
Specialisation: Neurological infection and inflammatory diseases
foto D. van de Beek is one of the AMC Principal Investigators
Focus of research:

The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovasculair disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.

We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the erea's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.

 

AMC themes: Infection & Immunity, Neurological & Psychiatric Disorders
Departments: Neurology
Bartelsman M, Joore IK, van Bergen JE, Hogewoning AA, Zuure FR, van Veen MG [Contributors: van Bergen JEAM, Deug F, Heidenrijk M, Prins JM, Prins M, Smit PJ, van der Valk M, Reiss P, de Bree GJ, Hoornenborg E, Davidovich U, Geerlings SE, Oomen A, van sighem A, Zuilhof W, Achterbergh RCA, van Agtmael M, Ananworanich J, van de Beek D, van den Berk GEL, Berkhout B, Berretty B, Bezemer D, Blok WL, Bomers M, Boucher CAB, Brokking W, Burger D, Brinkman K, de Bruin M, Op de Coul ELM, O'Dell B, Dellemann L, Ester C, van Duijnhoven YT, Dijkstra M, van Eeden A, van Elsen S, Elsenburg L, Frissen PHJ, Geijtenbeek TBH, Godfried MH, Goorhuis A, Groot M, Gruters RA, Hankins CA, Heijne A, van der Helm JJ, Hillebregt M, Hogewoning A, Hovius JW, Joore IK, Kootstra NA, Koup RA, Kroon FP, Lauw F, Lettinga K, Mahmoudi T, van der Meer JT, van Meeteren S, Mulder J, Nellen FJ, Nobel H, Pasternak AO, Peters E, van der Poll T, Schim van der Loeff MF , Schoute WEM, Rokx C, van Rooijen MS, Sonder GJ, van Veen MG, Veenstra J, Verbon A, Verdult F, Verhagen D, Visser G, de Vries HJ, de Vocht J, Vrouenraets S, van Vugt M, Wiersinga WJ, Wit FW, Woittiez LR, Zaheri S, van Zelm MC, Zuure FR]] , HIV testing week 2015: lowering barriers for HIV testing among high-risk groups in Amsterdam. BMC INFECT DIS 2017;17 (1):529 [PubMed]
Brouwer MC, van de Beek D, Epidemiology, diagnosis, and treatment of brain abscesses. CURR OPIN INFECT DIS 2017;30 (1):129-134 [PubMed]
Brouwer MC, van de Beek D, Management of bacterial central nervous system infections. HANDB CLIN NEUROL 2017;140:349-364 [PubMed]
Brouwer MC, van de Beek D, MONALISA: a grim picture of listeriosis. LANCET INFECT DIS 2017;17 (5):464-466 [PubMed]
Costerus JM, Brouwer MC, Bijlsma MW, van de Beek D, Community-acquired bacterial meningitis. CURR OPIN INFECT DIS 2017;30 (1):135-141 [PubMed]
Dias SP, Brouwer MC, Bijlsma MW, van der Ende A, van de Beek D, Sex-based differences in adults with community-acquired bacterial meningitis: a prospective cohort study. CLIN MICROBIOL INFEC 2017;23 (2):e9-121.e15-121.e15 [PubMed]
Fritz D, Voortman M, van de Beek D, Drent M, Brouwer MC, Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. CURR OPIN PULM MED 2017;23 (5):439-446 [PubMed]
Hoogmoed J, van de Beek D, Coert BA, Horn J , Vandertop WP, Verbaan D, Clinical and Laboratory Characteristics for the Diagnosis of Bacterial Ventriculitis After Aneurysmal Subarachnoid Hemorrhage. NEUROCRIT CARE 2017;26 (3):362-370 [PubMed]
Iovino F, Engelen-Lee JY, Brouwer M, van de Beek D, van der Ende A, Valls Seron M, Mellroth P, Muschiol S, Bergstrand J, Widengren J, Henriques-Normark B, pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion. J EXP MED 2017;214 (6):1619-1630 [PubMed]
Kasanmoentalib ES, Valls Seron M , Ferwerda B, Tanck MW, Zwinderman AH, Baas F, van der Ende A, Brouwer MC, van de Beek D, Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J NEUROINFLAMM 2017;14 (1):2 [PubMed]
Kasanmoentalib ES, Valls Seron M , Ferwerda B, Tanck MW, Zwinderman AH, Baas F, van der Ende A, Schwaeble WJ, Brouwer MC, van de Beek D, Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis (vol 14, pg 9, 2017). J NEUROINFLAMM 2017;14 (1):77 [PubMed]
Khatib U, van de Beek D, Lees JA, Brouwer MC, Adults with suspected central nervous system infection: A prospective study of diagnostic accuracy. J INFECTION 2017;74 (1):1-9 [PubMed]
Koopmans MM, Bijlsma MW, Brouwer MC, van de Beek D, van der Ende A, Listeria monocytogenes meningitis in the Netherlands, 1985-2014: A nationwide surveillance study. J INFECTION 2017;75 (1):12-19 [PubMed]
Kremer PHC, Lees JA, Koopmans MM, Ferwerda B, Arends AWM, Feller MM, Schipper K, Valls Seron M , van der Ende A, Brouwer MC, van de Beek D, Bentley SD, Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis. CLIN MICROBIOL INFEC 2017;23 (4):265E1-265E7 [PubMed]
Lees JA, Brouwer M, van der Ende A, Parkhill J, van de Beek D, Bentley SD, Within-Host Sampling of a Natural Population Shows Signs of Selection on Pde1 during Bacterial Meningitis. INFECT IMMUN 2017;85 (3):UNSP e01061-16 [PubMed]
Lees JA, Kremer PHC, Manso AS, Croucher NJ, Ferwerda B, Valls Serón M, Oggioni MR, Parkhill J, Brouwer MC, van der Ende A, van de Beek D, Bentley SD, Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis. MICROB GENOM 2017;3 (1):e000103 [PubMed]
Pannekoek Y, Huis In 't Veld RAG, Schipper K, Bovenkerk S, Kramer G, Brouwer MC, van de Beek D, Speijer D, van der Ende A, Neisseria meningitidis Uses Sibling Small Regulatory RNAs To Switch from Cataplerotic to Anaplerotic Metabolism. MBIO 2017;8 (2):e02293-16 [PubMed]
Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Michael Scheld W, van de Beek D, Bleck TP, Garton HJL, Zunt JR, 2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. CLIN INFECT DIS 2017;64 (6):E34-E65 [PubMed]
van Bilsen WPH, van den Berg CHSB, Rijnders BJA, Brinkman K, Mulder JW, Gelinck LBS, Hoepelman AIM, Wit FWNM, van de Beek D, Prins JM, Immune reconstitution inflammatory syndrome associated with toxoplasmic encephalitis in HIV-infected patients. AIDS 2017;31 (10):1415-1424 [PubMed]
van de Beek D, Brouwer MC, 2016, the year of Zika virus. NAT REV NEUROL 2017;13 (2):69-70 [PubMed]
van de Beek D, Brouwer MC, Neurological infections in 2016: Zika and the rest. LANCET NEUROL 2017;16 (1):17-18 [PubMed]
van Ettekoven CN, van de Beek D, Brouwer MC, Update on community-acquired bacterial meningitis: guidance and challenges. CLIN MICROBIOL INFEC 2017;23 (9):601-606 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in alcoholic patients: A population-based prospective study. J INFECTION 2017;74 (4):352-357 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial Meningitis in Patients using Immunosuppressive Medication: a Population-based Prospective Nationwide Study. J NEUROIMMUNE PHARM 2017;12 (2):213-218 [PubMed]
Voortman M, Fritz D, Vogels OJM, Eftimov F, van de Beek D, Brouwer MC, Drent M, Small fiber neuropathy: a disabling and underrecognized syndrome. CURR OPIN PULM MED 2017;23 (5):447-457 [PubMed]
Wyllie AL, Pannekoek Y, Bovenkerk S, van Engelsdorp Gastelaars J, Ferwerda B, van de Beek D, Sanders EAM, Trzciński K, van der Ende A, Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species. OPEN BIOL 2017;7 (9):170074 [PubMed]
Zonneveld TP, Nederkoorn PJ, Westendorp WF, Brouwer MC, van de Beek D, Kruyt ND [Contributors: Vermeij JD, Zock E, Hooijenga IJ, Kerkhoff H, Kleyweg RP, Kwa VIH, Bosboom JLW, Weisfelt M, Remmers MJM, van Dijk EJ, Vermeij FH, Schreuder AHCML, Vermeer SE, ten Houten R, Dippel DWJ, Kappelle LJ, van der Worp HB, Merkies ISJ, de Bruijn SFTM, de Laat KF, Jellema K, Keizer K, de Rijk MC, Vermeij AJ, Visser MC, Aerden LAM, Schut ES, Reichman LJA, de Gans K, van den Berg-Vos RM, van Goor MPJ, Wijnhoud AD, van der Ree TC, Janmaat M, van Orshoven NP, Manschot SM]] , Hyperglycemia predicts poststroke infections in acute ischemic stroke. NEUROLOGY 2017;88 (15):1415-1421 [PubMed]
Bijlsma MW. Bacterial meningitis: epidemiology, herd protection, clinical characteristics, and risk assessment. S.l.: s.n.; 2016. 173p. ISBN 978-94-6299-365- [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): van der Ende A, Brouwer MC)
Bijlsma MW, Brouwer MC, Bossuyt PM, Heymans MW, van der Ende A, Tanck MWT, van de Beek D, Risk scores for outcome in bacterial meningitis: Systematic review and external validation study. J INFECTION 2016;73 (5):393-401 [PubMed]
Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D, Community-acquired bacterial meningitis in adults in the Netherlands, 2006-14: a prospective cohort study. LANCET INFECT DIS 2016;16 (3):339-347 [PubMed]
Brouwer MC, Wijdicks EFM, van de Beek D, What's new in bacterial meningitis. INTENS CARE MED 2016;42 (3):415-417 [PubMed]
Costerus JM , Brouwer MC, Bijlsma MW, Tanck MW, van der Ende A, van de Beek D, Impact of an evidence-based guideline on the management of community-acquired bacterial meningitis: a prospective cohort study. CLIN MICROBIOL INFEC 2016;22 (11):928-933 [PubMed]
Costerus JM , Brouwer MC, van der Ende A, van de Beek D, Repeat lumbar puncture in adults with bacterial meningitis. CLIN MICROBIOL INFEC 2016;22 (5):428-433 [PubMed]
Costerus JM, Brouwer MC, van der Ende A, van de Beek D, Community-acquired bacterial meningitis in adults with cancer or a history of cancer. NEUROLOGY 2016;86 (9):860-866 [PubMed]
Dias SP, Brouwer MC, Bijlsma MW, van der Ende A, van de Beek D, Sex-based differences in pneumococcal serotype distribution in adults with pneumococcal meningitis. J INFECTION 2016;73 (6):616-619 [PubMed]
Duitman J, Valls Serón M, Engelen-Lee J, Brouwer MC, Spek CA, van de Beek D, Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection. BMC INFECT DIS 2016;16 (1):670 [PubMed]
Engelen-Lee JY, Brouwer MC, Aronica E, van de Beek D, Pneumococcal meningitis: Clinical-pathological correlations (meningene-path). ACTA NEUROPATHOL COM 2016;4 (1):26 [PubMed]
Ferwerda B, Valls Serón M, Jongejan A, Zwinderman AH, Geldhoff M, van der Ende A, Baas F, Brouwer MC, van de Beek D, Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome. EBIOMEDICINE 2016;10:77-84 [PubMed]
Fritz D, van de Beek D, Brouwer MC, Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis. BMC NEUROL 2016;16 (1):220 [PubMed]
Gathier CS, Oostdijk EA, Rinkel GJE, Dorhout Mees SM, Vergouwen MDI, de Smet AMGA, van de Beek D, Vandertop WP, Verbaan D, Algra A, Bonten MJM, van den Bergh WM, Preventive Antibiotics and Delayed Cerebral Ischaemia in Patients with Aneurysmal Subarachnoid Haemorrhage Admitted to the Intensive Care Unit. NEUROCRIT CARE 2016;24 (1):122-127 [PubMed]
Geldhoff M. Pathophysiology of pneumococcal meningitis. S.l.: s.n.; 2016. 215p. ISBN 978-94-6332-062-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D, van der Poll T; copromotor(s): Brouwer MC)
Jim KK, Engelen-Lee J, van der Sar AM, Bitter W, Brouwer MC, van der Ende A, Veening JW, van de Beek D, Vandenbroucke-Grauls CMJE, Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model. J NEUROINFLAMM 2016;13 (1):188 [PubMed]
Kloek AT, van Setten J, van der Ende A, Bots ML, Asselbergs FW, Valls Serón M, Brouwer MC, van de Beek D, Ferwerda B, Exome Array Analysis of Susceptibility to Pneumococcal Meningitis. SCI REP-UK 2016;6:29351 [PubMed]
Leonhard SE, Fritz D, Eftimov F, van der Kooi AJ, van de Beek D, Brouwer MC, Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study. MEDICINE 2016;95 (14):e3277 [PubMed]
Leonhard SE, Fritz D, van de Beek D, Brouwer MC, Cryptococcal meningitis complicating sarcoidosis. MEDICINE 2016;95 (35):e4587 [PubMed]
Lucas MJ. Complications and outcome of bacterial meningitis. S.l.: s.n.; 2016. 159p. ISBN 978-94-6332-024-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): Brouwer MC)
Lucas MJ, Brouwer MC, van de Beek D, Neurological sequelae of bacterial meningitis. J INFECTION 2016;73 (1):18-27 [PubMed]
Panackal AA, Williamson KC, van de Beek D, Boulware DR, Williamson PR, Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections. MBIO 2016;7 (1):e01906-e01915 [PubMed]
Piet JR. Bacterial genetics in meningitis: Associating meningococcal and pneumococcal genes with clinical outcome. S.l.: s.n.; 2016. 206p. ISBN 978-94-6332-027-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): van der Ende A)
Piet JR, van Ulsen P, Ur Rahman S, Bovenkerk S, Bentley SD, van de Beek D, van der Ende A, Meningococcal Two-Partner Secretion Systems and Their Association with Outcome in Patients with Meningitis. INFECT IMMUN 2016;84 (9):2534-2540 [PubMed]
Savva A, Brouwer MC, Roger T, Valls Serón M, le Roy D, Ferwerda B, van der Ende A, Bochud PY, van de Beek D, Calandra T, Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis. P NATL ACAD SCI USA 2016;113 (13):3597-3602 [PubMed]
Valls Serón M, Ferwerda B, Engelen-Lee J, Geldhoff M, Jaspers V, Zwinderman AH, Tanck MW, Baas F, van der Ende A, Brouwer MC, van de Beek D, V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. ACTA NEUROPATHOL COM 2016;4 (1):50 [PubMed]
van de Beek D, Brouwer M, Hasbun R, Koedel U, Whitney CG, Wijdicks E, Community-acquired bacterial meningitis. NAT REV DIS PRIMERS 2016;2:16074 [PubMed]
van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, Leib SL, Mourvillier B, Ostergaard C, Pagliano P, Pfister HW, Read RC, Sipahi OR, Brouwer MC, ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. CLIN MICROBIOL INFEC 2016;22 (Suppl. 3):S37-S62 [PubMed]
van Samkar A. Zoonotic bacterial meningitis in adults: clinical characteristics, etiology, treatment and outcome. S.l.: s.n.; 2016. 151p. ISBN 978-94-6332-068-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): Brouwer MC, van der Ende A)
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D, Capnocytophaga canimorsus Meningitis: Three Cases and a Review of the Literature. ZOONOSES PUBLIC HLTH 2016;63 (6):442-448 [PubMed]
van Samkar A, Brouwer MC, van der Ende A, van de Beek D, Campylobacter Fetus Meningitis in Adults: Report of 2 Cases and Review of the Literature. MEDICINE 2016;95 (8):e2858 [PubMed]
van Samkar A, Brouwer MC, van der Ende A, van de Beek D, Streptococcus equi meningitis. CLIN MICROBIOL INFEC 2016;22 (1):e3-e4 [PubMed]
van Samkar A, Brouwer MC, van der Ende A, van de Beek D, Zoonotic bacterial meningitis in human adults. NEUROLOGY 2016;87 (11):1171-1179 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in diabetes patients: a population-based prospective study. SCI REP-UK 2016;6:36996 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in hematopoietic stem cell transplant recipients: a population-based prospective study. BONE MARROW TRANSPL 2016;51 (11):1490-1495 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in patients with HIV: A population-based prospective study. J INFECTION 2016;72 (3):362-368 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in solid organ transplant recipients: a population-based prospective study. TRANSPL INFECT DIS 2016;18 (5):674-680 [PubMed]
Vermeij JD, Westendorp WF, Roos YB, Brouwer MC, van de Beek D, Nederkoorn PJ, Preventive Ceftriaxone in Patients with Stroke Treated with Intravenous Thrombolysis: Post Hoc Analysis of the Preventive Antibiotics in Stroke Study. CEREBROVASC DIS 2016;42 (5-6):361-369 [PubMed]
Westendorp WF, Vermeij JD, Brouwer MC, Roos YBWEM, Nederkoorn PJ, van de Beek D, Pre-Stroke Use of Beta-Blockers Does Not Lower Post-Stroke Infection Rate: An Exploratory Analysis of the Preventive Antibiotics in Stroke Study. CEREBROVASC DIS 2016;42 (5-6):506-511 [PubMed]
Wildenbeest JG, Said I, Jaeger B, van Hest RM, van de Beek D, Pajkrt D, Neonate with Mycoplasma hominis meningoencephalitis given moxifloxacin. LANCET INFECT DIS 2016;16 (11):e261-e266 [PubMed]
Zock E, Kerkhoff H, Kleyweg RP, van Bavel-Ta TBV, Scott S, Kruyt ND, Nederkoorn PJ, van de Beek D, Help seeking behavior and onset-to-alarm time in patients with acute stroke: sub-study of the preventive antibiotics in stroke study. BMC NEUROL 2016;16 (1):241 [PubMed]
Zock E, Kerkhoff H, Kleyweg RP, van de Beek D, Intrinsic factors influencing help-seeking behaviour in an acute stroke situation. ACTA NEUROL BELG 2016;116 (3):295-301 [PubMed]
Adriani KS. Risk factors for community-acquired bacterial meningitis in adults. S.l.: s.n.; 2015. 136p. ISBN 978-94-90791-37-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): Brouwer MC)
Adriani KS, Brouwer MC, van de Beek D, Risk factors for community-acquired bacterial meningitis in adults. NETH J MED 2015;73 (2):53-60 [PubMed]
Beishuizen SJ, Scholtens RM, Vellekoop AE, Vrouenraets BC, Westhoff D, van de Beek D, de Rooij SE, van Munster BC, Timing Is Critical in Determining the Association Between Delirium and S100 Calcium-Binding Protein B. J AM GERIATR SOC 2015;63 (10):2212-2214 [PubMed]
Brouwer MC, McIntyre P, Prasad K, van de Beek D, Corticosteroids for acute bacterial meningitis. COCHRANE DB SYST REV 2015;2015 (9):CD004405 [PubMed]
Brouwer MC, van de Beek D, Earlier Treatment and Improved Outcome in Adult Bacterial Meningitis Following Guideline Revision Promoting Prompt Lumbar Puncture. CLIN INFECT DIS 2015;61 (4):664-665 [PubMed]
Coumou J, Herkes EA, Brouwer MC, van de Beek D, Tas SW, Casteelen G , van Vugt M, Starink MV, de Vries HJC, de Wever B, Spanjaard L, Hovius JWR, Ticking the right boxes: classification of patients suspected of Lyme borreliosis at an academic referral center in the Netherlands. CLIN MICROBIOL INFEC 2015;21 (4):368.e11-368.e20 [PubMed]
Dirks M, Zonneveld TP, Dippel DWJ, Nederkoorn PJ, van de Beek D, van Oostenbrugge RJ, Kruyt ND, Elevated pretreatment blood pressure and IV thrombolysis in stroke. NEUROLOGY 2015;84 (14):1419-1425 [PubMed]
Hoogland ICM, Houbolt C, van Westerloo DJ, van Gool WA, van de Beek D, Systemic inflammation and microglial activation: systematic review of animal experiments. J NEUROINFLAMM 2015;12 (1):114 [PubMed]
Kasanmoentalib ES, Valls Seron M , Morgan BP, Brouwer MC, van de Beek D, Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a randomized controlled trial. J NEUROINFLAMM 2015;12 (1):149 [PubMed]
Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ, How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis. STROKE 2015;46 (5):1202-1209 [PubMed]
Lammers AJJ, Goorhuis A, van de Beek D, Grobusch MP, Bart A, van Gool T, van Vugt M, Eosinophilia à deux: a brain nagging souvenir from the Philippines. INFECTION 2015;43 (5):615-617 [PubMed]
Lucas MJ, Brouwer MC, Bovenkerk S, Man WK, van der Ende A, van de Beek D, Group A Streptococcal meningitis in adults. J INFECTION 2015;71 (1):37-42 [PubMed]
Mook BB. Translational studies in pneumococcal meningitis. S.l.: s.n.; 2015. 188p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): Brouwer MC)
Mook-Kanamori BB, Valls Serón M, Geldhoff M, Havik SR, van der Ende A, Baas F, van der Poll T, Meijers JCM, P Morgan B, Brouwer MC, van de Beek D, Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis. J THROMB HAEMOST 2015;13 (11):2076-2086 [PubMed]
Smith CJ, Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group. STROKE 2015;46 (8):2335-2340 [PubMed]
Valls Serón M, Duitman J, Geldhoff M, Engelen-Lee J, Havik SR, Brouwer MC, van de Beek D, Spek CA, CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis. J NEUROINFLAMM 2015;12 (1):88 [PubMed]
van de Beek D. Infecties in: Hijdra A, Koudstaal PJ, Roos RA, editors. Neurologie (6e herz. dr.). Amsterdam: Reed Business education; 2015. -, p. 293-308
van de Beek D, Brouwer M, Nederkoorn P, Parenteral antibiotics are not enough to prevent pneumonia in stroke - Authors' reply. LANCET 2015;386 (9994):653-654 [PubMed]
van Samkar A, Brouwer MC, Pannekoek Y, van der Ende A, van de Beek D, Streptococcus gallolyticus meningitis in adults: report of five cases and review of the literature. CLIN MICROBIOL INFEC 2015;21 (12):1077-1083 [PubMed]
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D, Streptococcus suis Meningitis: A Systematic Review and Meta-analysis. PLOS NEGLECT TROP D 2015;9 (10):e0004191 [PubMed]
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D, Streptococcus suis meningitis in the Netherlands. J INFECTION 2015;71 (5):602-604 [PubMed]
van Samkar A, van de Beek D, Stijnis C, Goris M, Brouwer MC, Suspected leptospiral meningitis in adults: report of four cases and review of the literature. NETH J MED 2015;73 (10):464-470 [PubMed]
Westendorp WF, Vermeij JD, Zock E, Hooijenga IJ, Kruyt ND, Bosboom HJLW, Kwa VIH, Weisfelt M, Remmers MJM, ten Houten R, Schreuder AHCMT, Vermeer SE, van Dijk EJ, Dippel DWJ, Dijkgraaf MGW, Spanjaard L, Vermeulen M, van der Poll T, Prins JM, Vermeij FH, Roos YBWEM, Kleyweg RP, Kerkhoff H, Brouwer MC, Zwinderman AH, van de Beek D, Nederkoorn PJ [Contributors: van de Beek D, Nederkoorn PJ, Westendorp WF , Vermeij JD, Kerkhoff H, Zock E, Kleyweg RP, Bosboom JLW, Kwa VIH, Weisfelt M, Kruyt ND, Remmers MJM, van Dijk EJ, Vermeij F, Schreuder A, Vermeer SE, ten Houten R, Dippel DWJ, Kappelle LJ, van der Worp HB, Merkies ISJ, de Bruijn SFTM, de Laat KF, Haag D, Jellema K, Keizer K, de Rijk MC, Vermeij AJ, Visser MC, Aerden LAM, Schut ES, Reichman LJA, de Gans K, van den Berg-Vos RM, van Goor MPJ, Wijnhoud AD, van der Ree TC, Janmaat M, van Orshoven N, Manschot SM, Dijkgraaf MGW, van der Poll T, Prins JM, Spanjaard L, Vermeij FH]] , The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial. LANCET 2015;385 (9977):1519-1526 [PubMed]
Westhoff D, Witlox J, van Aalst C, Scholtens RM, de Rooij SE, van Munster BC, de Jonghe JFM, Houdijk APJ, Eikelenboom P, van Westerloo DJ, van de Beek D, van Gool WA, Koenderman L, Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study. BBA CLIN 2015;4:115-122 [PubMed]
Bekker V, Bijlsma MW, van de Beek D, Kuijpers TW, van der Ende A, Incidence of invasive group B streptococcal disease and pathogen genotype distribution in newborn babies in the Netherlands over 25 years: a nationwide surveillance study. LANCET INFECT DIS 2014;14 (11):1083-1089 [PubMed]
Bijlsma MW, Bekker V, Brouwer MC, Spanjaard L, van de Beek D, van der Ende A, Epidemiology of invasive meningococcal disease in the Netherlands, 1960-2012: an analysis of national surveillance data. LANCET INFECT DIS 2014;14 (9):805-812 [PubMed]
Bijlsma MW, Brouwer MC, Spanjaard L, van de Beek D, van der Ende A, A decade of herd protection after introduction of meningococcal serogroup C conjugate vaccination. CLIN INFECT DIS 2014;59 (9):1216-1221 [PubMed]
Bijlsma MW, Brouwer MC, van den Kerkhof H, Knol MJ, van de Beek D, van der Ende A, No evidence of clusters of serogroup C meningococcal disease in the Dutch MSM community. J INFECTION 2014;68 (3):296-297 [PubMed]
Brouwer MC, Coutinho JM, van de Beek D, Clinical characteristics and outcome of brain abscess Systematic review and meta-analysis. NEUROLOGY 2014;82 (9):806-813 [PubMed]
Brouwer MC, Meijers JCM, Baas F, van der Ende A, Pfister HW, Giese A, van de Beek D, Koedel U, Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. ACTA NEUROPATHOL 2014;127 (4):553-564 [PubMed]
Brouwer MC, Tunkel AR, McKhann GM 2nd, van de Beek D, Brain Abscess. NEW ENGL J MED 2014;371 (5):447-456 [PubMed]
Brouwer MC, Tunkel AR, van de Beek D, Brain abscess. NEW ENGL J MED 2014;371 (18):1758 [PubMed]
Brouwer MC, van de Beek D. Bacterial Meningitis in: Farrar J, Hotez J, Junghans T, Kang G, Lallo D, White N, editors. Manson's tropical diseases, 23rd ed. S.l.: Elsevier; 2014. -, p. 361-369
du Plessis M, Wolter N, Crowther-Gibson P, Hamstra HJ, Schipper K, Moodley C, Cohen C, van de Beek D, van der Ley P, von Gottberg A, van der Ende A, Meningococcal serogroup Y lpxL1 variants from South Africa are associated with clonal complex 23 among young adults. J INFECTION 2014;68 (5):455-461 [PubMed]
Heckenberg SGB, Brouwer MC, van de Beek D, Bacterial meningitis. HANDB CLIN NEUROL 2014;121:1361-1375 [PubMed]
Klein M, Brouwer MC, Angele B, Geldhoff M, Marquez G, Varona R, Häcker G, Schmetzer H, Häcker H, Hammerschmidt S, van der Ende A, Pfister HW, van de Beek D, Koedel U, Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis. PLOS ONE 2014;9 (4):e93057 [PubMed]
Koopmans MM, Brouwer MC, Geldhoff M, Seron MV, Houben J, van der Ende A, van de Beek D, Cerebrospinal fluid inflammatory markers in patients with Listeria monocytogenes meningitis. BBA CLIN 2014;1:44-51 [PubMed]
Lucas MJ, Brouwer MC, van der Ende A, van de Beek D, Outcome in patients with bacterial meningitis presenting with a minimal Glasgow Coma Scale score. NEUROL NEUROIMMUNOL NEUROINFLAMM 2014;1 (1):e9 [PubMed]
Mook-Kanamori BB, Brouwer MC, Geldhoff M, Ende Avd, van de Beek D, Cerebrospinal fluid complement activation in patients with pneumococcal and meningococcal meningitis. J INFECTION 2014;68 (6):542-547 [PubMed]
Nederkoorn PJ, van de Beek D, Update protocol Preventive Antibiotics in Stroke Study (PASS). INT J STROKE 2014;9 (5):E22 [PubMed]
Piet JR, Geldhoff M, van Schaik BDC, Brouwer MC, Valls Seron M , Jakobs ME, Schipper K, Pannekoek Y, Zwinderman AH, van der Poll T, van Kampen AHC, Baas F, van der Ende A, van de Beek D, Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis. J INFECT DIS 2014;209 (11):1781-1791 [PubMed]
Piet JR, Zariri A, Fransen F, Schipper K, van der Ley P, van de Beek D, van der Ende A, Meningitis caused by a lipopolysaccharide deficient Neisseria meningitidis. J INFECTION 2014;69 (4):352-357 [PubMed]
Roos KL, Tunkel AR, van de Beek D, Scheld WM. Acute bacterial meningitis in: Scheld WM, Whitley RJ, Marra CM, editors. Infections of the central nervous system (4th ed.). Philadelphia: Wolters Kluwer; 2014. 4, p. 365-420
Tunkel AR, van de Beek D, Scheld WM. Acute meningitis in: Bennett JE, Dolin R, Blaser MJ, editors. Principles and practice of infectious diseases (8th ed.). Philadelphia: Elsevier; 2014., p. 1097-1138
van 't Hof FNG, Kurki MI, Kleinloog R, de Bakker PIW, von Und Zu Fraunberg M, Jääskeläinen JE, Gaál EI, Lehto H, Kivisaari R, Laakso A, Niemelä M, Hernesniemi J, Brouwer MC, van de Beek D, Rinkel GJE, Ruigrok YM, Genetic risk load according to the site of intracranial aneurysms. NEUROLOGY 2014;83 (1):34-39 [PubMed]
Westendorp WF, Vermeij JD, Dippel DWJ, Dijkgraaf MGW, van der Poll T, Prins JM, Vermeij FH, Roos YBWEM, Brouwer MC, Zwinderman AH, van de Beek D, Nederkoorn PJ, Update of the Preventive Antibiotics in Stroke Study (PASS): statistical analysis plan. TRIALS 2014;15 (1):382 [PubMed]
Westendorp WF, Vermeij JD, van Geloven N, Dippel DWJ, Dijkgraaf MGW, van der Poll T, Prins JM, Spanjaard L, Vermeij FH, Nederkoorn PJ, van de Beek D, Update on the Preventive Antibiotics in Stroke Study (PASS): a randomised controlled phase 3 clinical trial. TRIALS 2014;15 (1):133 [PubMed]
Adriani KS, Brouwer MC, Geldhoff M, Baas F, Zwinderman AH, Paul Morgan B, Harris CL, van der Ende A, van de Beek D, Common polymorphisms in the complement system and susceptiblity to bacterial meningitis. J INFECTION 2013;66 (3):255-262 [PubMed]
Adriani KS, Brouwer MC, van der Ende A, van de Beek D, Bacterial Meningitis in Adults After Splenectomy and Hyposplenic States. MAYO CLIN PROC 2013;88 (6):571-578 [PubMed]
Bambini S, Piet J, Muzzi A, Keijzers W, Comandi S, de Tora L, Pizza M, Rappuoli R, van de Beek D, van der Ende A, Comanducci M, An analysis of the sequence variability of meningococcal fHbp, NadA and NHBA over a 50-year period in the Netherlands. PLOS ONE 2013;8 (5):e65043 [PubMed]
Bijlsma MW, Brouwer MC, van de Beek D, Prognostic risk score for pleocytosis with a negative gram stain: valid but of limited utility in bacterial meningitis patients. MAYO CLIN PROC 2013;88 (4):421 [PubMed]
Boelman CG, Brouwer MC, van de Beek D, Adjunctive dexamethasone in adults with meningococcal meningitis. NEUROLOGY 2013;80 (19):1818-1819 [PubMed]
Brouwer MC, Baas F, van der Ende A, van de Beek D, Genetic variation and cerebrospinal fluid levels of mannose binding lectin in pneumococcal meningitis patients. PLOS ONE 2013;8 (5):e65151 [PubMed]
Brouwer MC, Jim KK, Benschop KS, Wolthers KC, van der Ende A, de Jong MD, van de Beek D, No evidence of viral coinfection in cerebrospinal fluid from patients with community-acquired bacterial meningitis. J INFECT DIS 2013;208 (1):182-184 [PubMed]
Brouwer MC, McIntyre P, Prasad K, van de Beek D, Corticosteroids for acute bacterial meningitis. COCHRANE DB SYST REV 2013;2013 (6):CD004405 [PubMed]
Brouwer MC, van de Beek D, Intensified intravenous rifampicin in tuberculous meningitis. LANCET INFECT DIS 2013;13 (1):2-3 [PubMed]
Denneman L, Vial-Dupuy A, Gault N, Wolff M, van de Beek D, Mourvillier B, Repeated lumbar puncture in adults with pneumococcal meningitis: An observational study. J INFECTION 2013;67 (4):350-353 [PubMed]
Geldhoff M, Mook-Kanamori BB, Brouwer MC, Troost D, Leemans JC, Flavell RA, van der Ende A, van der Poll T, van de Beek D, Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis. BMC INFECT DIS 2013;13 (1):358 [PubMed]
Geldhoff M, Mook-Kanamori BB, Brouwer MC, Valls Seron M , Baas F, van der Ende A, van de Beek D, Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis. IMMUNOGENETICS 2013;65 (1):9-16 [PubMed]
Hasbun R, Bijlsma M, Brouwer MC, Khoury N, Hadi CM, van der Ende A, Wootton SH, Salazar L, Hossain MM, Beilke M, van de Beek D, Risk score for identifying adults with CSF pleocytosis and negative CSF Gram stain at low risk for an urgent treatable cause. J INFECTION 2013;67 (2):102-110 [PubMed]
Heckenberg SGB. Bacterial meningitis in adults. Host and pathogen factors, treatment and outcome. s.l.: s.n.; 2013. 197p. ISBN 9789064646508 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): )
Iovino F, Brouwer MC, van de Beek D, Molema G, Bijlsma JJE, Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease. CELL MICROBIOL 2013;15 (6):870-881 [PubMed]
Kasanmoentalib ES, Brouwer MC, van de Beek D, Update on bacterial meningitis: epidemiology, trials and genetic association studies. CURR OPIN NEUROL 2013;26 (3):282-288 [PubMed]
Koopmans MM, Brouwer MC, Bijlsma MW, Bovenkerk S, Keijzers W, van der Ende A, van de Beek D, Listeria monocytogenes sequence type 6 and increased rate of unfavorable outcome in meningitis: epidemiologic cohort study. CLIN INFECT DIS 2013;57 (2):247-253 [PubMed]
Lucas MJ, Brouwer MC, van de Beek D, Delayed cerebral thrombosis in bacterial meningitis: a prospective cohort study. INTENS CARE MED 2013;39 (5):866-871 [PubMed]
Lucas MJ, Brouwer MC, van der Ende A, van de Beek D, Endocarditis in adults with bacterial meningitis. CIRCULATION 2013;127 (20):2056-2062 [PubMed]
Mourvillier B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D, Chillet P, Clair B, Constantin JM, Duguet A, Galliot R, Bayle F, Hyvernat H, Ouchenir K, Plantefeve G, Quenot JP, Richecoeur J, Schwebel C, Sirodot M, Esposito-Farèse M, Le Tulzo Y, Wolff M, Induced Hypothermia in Severe Bacterial Meningitis A Randomized Clinical Trial. JAMA-J AM MED ASSOC 2013;310 (20):2174-2183 [PubMed]
van de Beek D, Stroke: long-term effect of infections after stroke. NAT REV NEUROL 2013;9 (3):126-127 [PubMed]
Vermeij JD, Aslami H, Fluiter K, Roelofs JJ, van den Bergh WM, Juffermans NP, Schultz MJ, van der Sluijs K, van de Beek D, van Westerloo DJ, Traumatic brain injury in rats induces lung injury and systemic immune suppression. J NEUROTRAUM 2013;30 (24):2073-2079 [PubMed]
Westhoff D, Witlox J, Koenderman L, Kalisvaart KJ, de Jonghe JFM, van Stijn MFM, Houdijk APJ, Hoogland ICM, Maclullich AMJ, van Westerloo DJ, van de Beek D, Eikelenboom P, van Gool WA, Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients. J NEUROINFLAMM 2013;10 (1):122 [PubMed]
Adriani KS, Brouwer MC, Baas F, Zwinderman AH, van der Ende A, van de Beek D, Genetic Variation in the beta 2-Adrenocepter Gene Is Associated with Susceptibility to Bacterial Meningitis in Adults. PLOS ONE 2012;7 (5):e37618 [PubMed]
Adriani KS, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in pregnancy: report of six cases and review of the literature. CLIN MICROBIOL INFEC 2012;18 (4):345-351 [PubMed]
Adriani KS, van de Beek D, Troost D, Brouwer MC, The Diagnostic Pitfall of Infratentorial Subdural Empyema. ARCH NEUROL-CHICAGO 2012;69 (8):1076-1077 [PubMed]
Brouwer MC, Thwaites GE, Tunkel AR, van de Beek D, Dilemmas in the diagnosis of acute community-acquired bacterial meningitis. LANCET 2012;380 (9854):1684-1692 [PubMed]
Brouwer MC, van de Beek D, Bacteriële meningitis. NED TIJDSCHR TANDHEELKD 2012;119 (5):238-242 [PubMed]
Brouwer MC, van der Ende A, Baas F, van de Beek D, Genetic variation in GLCCI1 and dexamethasone in bacterial meningitis. J INFECTION 2012;65 (5):465-467 [PubMed]
Chamorro A, Meisel A, Planas AM, Urra X, van de Beek D, Veltkamp R, The immunology of acute stroke. NAT REV NEUROL 2012;8 (7):401-410 [PubMed]
Costerus JM, van de Beek D, Brouwer MC, Nosocomial meningitis caused by gas producing Klebsiella pneumoniae. BMJ CASE REP 2012;2012:bcr1120115137 [PubMed]
Fritz D, Brouwer MC, van de Beek D, Dexamethasone and long-term survival in bacterial meningitis. NEUROLOGY 2012;79 (22):2177-2179 [PubMed]
Heckenberg SGB, Brouwer MC, van der Ende A, Hensen EF, van de Beek D, Hearing loss in adults surviving pneumococcal meningitis is associated with otitis and pneumococcal serotype. CLIN MICROBIOL INFEC 2012;18 (9):849-855 [PubMed]
Heckenberg SGB, Brouwer MC, van der Ende A, van de Beek D, Adjunctive dexamethasone in adults with meningococcal meningitis. NEUROLOGY 2012;79 (15):1563-1569 [PubMed]
Jim KK, Brouwer MC, van der Ende A, van de Beek D, Cerebral abscesses in patients with bacterial meningitis. J INFECTION 2012;64 (2):236-238 [PubMed]
Jim KK, Brouwer MC, van der Ende A, van de Beek D, Subdural empyema in bacterial meningitis. NEUROLOGY 2012;79 (21):2133-2139 [PubMed]
McIntyre PB, O'Brien KL, Greenwood B, van de Beek D, Effect of vaccines on bacterial meningitis worldwide. LANCET 2012;380 (9854):1703-1711 [PubMed]
Mook-Kanamori BB, Fritz D, Brouwer MC, van der Ende A, van de Beek D, Intracerebral Hemorrhages in Adults with Community Associated Bacterial Meningitis in Adults: Should We Reconsider Anticoagulant Therapy?. PLOS ONE 2012;7 (9):e45271 [PubMed]
Mook-Kanamori B, Geldhoff M, Troost D, van der Poll T, van de Beek D, Characterization of a pneumococcal meningitis mouse model. BMC INFECT DIS 2012;12 (1):71 [PubMed]
Piet JR, Brouwer MC, Exley R, van der Veen S, van de Beek D, van der Ende A, Meningococcal Factor H Binding Protein fHbpd184 Polymorphism Influences Clinical Course of Meningococcal Meningitis. PLOS ONE 2012;7 (10):e47973 [PubMed]
Rodenburg GD, Fransen F, Bogaert D, Schipper K, Groenwold RHH, Hamstra HJ, Westerhuis BM, van de Beek D, van der Ley P, Sanders EAM, van der Ende A, Prevalence and Clinical Course in Invasive Infections with Meningococcal Endotoxin Variants. PLOS ONE 2012;7 (11):e49295 [PubMed]
Schut ES, Brouwer MC, Scarborough M, Mai NTH, Thwaites GE, Farrar JJ, Reitsma JB, van de Beek D, Validation of a Dutch Risk Score Predicting Poor Outcome in Adults with Bacterial Meningitis in Vietnam and Malawi. PLOS ONE 2012;7 (3):e34311 [PubMed]
Schut ES, Lucas MJ, Brouwer MC, Vergouwen MDI, van der Ende A, van de Beek D, Cerebral Infarction in Adults with Bacterial Meningitis. NEUROCRIT CARE 2012;16 (3):421-427 [PubMed]
van de Beek D, Progress and challenges in bacterial meningitis. LANCET 2012;380 (9854):1623-1624 [PubMed]
van de Beek D, The burden of serogroup B meningococcal disease. LANCET NEUROL 2012;11 (9):743-745 [PubMed]
van de Beek D, Brouwer MC, Thwaites GE, Tunkel AR, Advances in treatment of bacterial meningitis. LANCET 2012;380 (9854):1693-1702 [PubMed]
Westendorp WF, Vermeij JD, Vermeij F, den Hertog HM, Dippel DWJ, van de Beek D, Nederkoorn PJ, Antibiotic therapy for preventing infections in patients with acute stroke. COCHRANE DB SYST REV 2012;2012 (1):CD008530 [PubMed]
Westendorp WF, Vermeij JD, Vermeij F, den Hertog HM, Dippel DWJ, van de Beek D, Nederkoorn PJ, Preventive Antibiotics in Acute Stroke Summary of a Cochrane Systematic Review and Meta-Analysis. STROKE 2012;43 (11):E113-E114 [PubMed]
Wiersinga WJ, Prins JM, van de Beek D, Therapy-Resistant Opsoclonus-Myoclonus Syndrome Secondary to HIV-1 Infection. CLIN INFECT DIS 2012;54 (3):447-448 [PubMed]
Brouwer MC, Spanjaard L, Prins JM, van der Ley P, van de Beek D, van der Ende A, Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. J INFECTION 2011;62 (6):479-483 [PubMed]
Brouwer MC, van de Beek D, Glycerol in bacterial meningitis: one strike and out?. LANCET INFECT DIS 2011;11 (4):257-258 [PubMed]
de Souza LA, van de Beek D, Scheld WM. Meningococcal disease in: Guerrant RL, Walker DH, Weller PF, editors. Tropical infectious diseases: principles, pathogens & practice. London, UK: Elsevier; 2011., p. 174-183
Mateen FJ, Muralidharan R, Carone M, van de Beek D, Harrison DM, Aksamit AJ, Gould MS, Clifford DB, Nath A, Progressive multifocal leukoencephalopathy in transplant recipients. ANN NEUROL 2011;70 (2):305-322 [PubMed]
Mook-Kanamori BB, Geldhoff M, van der Poll T, van de Beek D, Pathogenesis and pathophysiology of pneumococcal meningitis. CLIN MICROBIOL REV 2011;24 (3):557-591 [PubMed]
Nederkoorn PJ, Westendorp WF, Hooijenga IJ, de Haan RJ, Dippel DWJ, Vermeij FH, Dijkgraaf MGW, Prins JM, Spanjaard L, van de Beek D, Preventive antibiotics in stroke study: rationale and protocol for a randomised trial. INT J STROKE 2011;6 (2):159-163 [PubMed]
Piet JR, Huis in 't Veld RAG, van Schaik BDC, van Kampen AHC, Baas F, van de Beek D, Pannekoek Y, van der Ende A, Genome sequence of Neisseria meningitidis serogroup B strain H44/76. J BACTERIOL 2011;193 (9):2371-2372 [PubMed]
van de Beek D. Infectious Diseases in the Nervous System in: Rabinstein AA, Klimo P, editors. Yearbook of Neurology and Neurosurgery 2011. Philadelphia, USA: Elsevier; 2011., p. 63-79
van de Beek D. Infectious Diseases of the Nervous System in: Rabinstein AA, Klimo P, editors. Yearbook of Neurology and Neurosurgery 2011. Philadelphia, USA: Elsevier; 2011., p. 73-78
Westendorp WF, Nederkoorn PJ, Vermeij JD, Dijkgraaf MG, van de Beek D, Post-stroke infection: a systematic review and meta-analysis. BMC NEUROL 2011;11:110 [PubMed]
Woehrl B, Brouwer MC, Murr C, Heckenberg SGB, Baas F, Pfister HW, Zwinderman AH, Morgan BP, Barnum SR, van der Ende A, Koedel U, van de Beek D, Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J CLIN INVEST 2011;121 (10):3943-3953 [PubMed]
Brouwer MC. Bacterial meningitis in adults: clinical characteristics, risk factors and adjunctive treatment. s.l.: s.n.; 2010. 258p. ISBN 9789090255873 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Vermeulen M; copromotor(s): van de Beek D)
Brouwer MC, Heckenberg SGB, de Gans J, Spanjaard L, Reitsma JB, van de Beek D, Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis. NEUROLOGY 2010;75 (17):1533-1539 [PubMed]
Brouwer MC, Kasanmoentalib ES, Opstelten FWJ, van der Ende A, van de Beek D, A horse bite to remember. LANCET 2010;376 (9747):1194 [PubMed]
Brouwer MC, McIntyre P, de Gans J, Prasad K, van de Beek D, Corticosteroids for acute bacterial meningitis. COCHRANE DB SYST REV 2010;2010 (9):CD004405 [PubMed]
Brouwer MC, Read RC, van de Beek D, Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis. LANCET INFECT DIS 2010;10 (4):262-274 [PubMed]
Brouwer MC, Tunkel AR, van de Beek D, Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis. CLIN MICROBIOL REV 2010;23 (3):467-+ [PubMed]
Brouwer MC, van de Beek D, An agitated man with earache. BMJ-BRIT MED J 2010;341:c3824 [PubMed]
del Pozo JL, van de Beek D, Mandrekar JN, Daly RC, McGregor CGA, Azanza JR, Patel R, High Serum Cholesterol Levels Are Associated with Herpes Zoster Infection after Heart Transplantation. CLIN INFECT DIS 2010;50 (1):121-122 [PubMed]
Klein M, Koedel U, Kastenbauer S, Pfister HW, van de Beek D, Schut ES, Brouwer MC, Steiner I, Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis?. NEUROLOGY 2010;75 (2):193; author reply 193-193; author reply 194 [PubMed]
Mateen FJ, Dierkhising RA, Rabinstein AA, van de Beek D, Wijdicks EFM, Neurological complications following adult lung transplantation. AM J TRANSPLANT 2010;10 (4):908-914 [PubMed]
Roos KL, van de Beek D, Bacterial meningitis. HANDB CLIN NEUROL 2010;96C:51-63 [PubMed]
Schmand B, de Bruin E, de Gans J, van de Beek D, Cognitive functioning and quality of life nine years after bacterial meningitis. J INFECTION 2010;61 (4):330-334 [PubMed]
Soemirien Kasanmoentalib E, Brouwer MC, van der Ende A, van de Beek D, Hydrocephalus in adults with community-acquired bacterial meningitis. NEUROLOGY 2010;75 (10):918-923 [PubMed]
van de Beek D. Acute and cronic meningitis in: Cohen J, Powderly WG, Opal SM, editors. Infectious Diseases. Philadelphia: Mosby Elsevier; 2010. 3, p. 206-217
van de Beek D. Koorts en neurologische uitval in: Bindels PJE, Vermeulen M, editors. Het Neurologie Formularium. S.l.: Bohn Stafleu van Loghum; 2010., p. 70-72
van de Beek D. Neuro-infecties in: Bindels PJE, Vermeulen M, editors. Het Neurologie Formularium. S.l.: Bohn Stafleu van Loghum; 2010., p. 196-202
van de Beek D, Brouwer MC, No difference between short-course and long-course antibiotics for bacterial meningitis in children, but available evidence limited. EVID BASED MED 2010;15 (1):6-7 [PubMed]
van de Beek D, Brouwer MC, Randomised controlled trial: Hearing loss after bacterial meningitis is predicted by presenting status and young age; effectiveness of adjuvant dexamethasone or glycerol unclear. EVID BASED MED 2010;15 (2):39-40 [PubMed]
van de Beek D, Drake JM, Tunkel AR, Nosocomial bacterial meningitis. NEW ENGL J MED 2010;362 (2):146-154 [PubMed]
van de Beek D, Drake JM, Tunkel AR, Nosocomial Bacterial Meningitis REPLY. NEW ENGL J MED 2010;362 (14):1347-1348
van de Beek D, Farrar JJ, de Gans J, Mai NTH, Molyneux EM, Peltola H, Peto TE, Roine I, Scarborough M, Schultsz C, Thwaites GE, Tuan PQ, Zwinderman AH, Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data. LANCET NEUROL 2010;9 (3):254-263 [PubMed]
van de Beek D, Thwaites GE, Farrar J. Bacterial infections of the central nervous system in: Warrell DA, Cox TM, Firth JD, editors. Oxford Textbook of Medicine. Oxford: Oxford University Press; 2010. 5, p. 4976-4997
van Gool WA, van de Beek D, Eikelenboom P, Systemic infection and delirium: when cytokines and acetylcholine collide. LANCET 2010;375 (9716):773-775 [PubMed]
Vergouwen MDI, Schut ES, Troost D, van de Beek D, Diffuse Cerebral Intravascular Coagulation and Cerebral Infarction in Pneumococcal Meningitis. NEUROCRIT CARE 2010;13 (2):217-227 [PubMed]
Weisfelt M, de Gans J, van der Ende A, van de Beek D, Community-acquired bacterial meningitis in alcoholic patients. PLOS ONE 2010;5 (2):e9102 [PubMed]
Brewer JD, Colegio OR, Phillips PK, Roenigk RK, Jacobs MA, van de Beek D, Dierkhising RA, Kremers WK, McGregor CGA, Otley CC, Incidence of and risk factors for skin cancer after heart transplant. ARCH DERMATOL 2009;145 (12):1391-1396 [PubMed]
Brouwer MC, de Gans J, Heckenberg SGB, Zwinderman AH, van der Poll T, van de Beek D, Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. LANCET INFECT DIS 2009;9 (1):31-44 [PubMed]
Brouwer MC, de Gans J, Willemse RB, van de Beek D, Neurological picture. Sarcoidosis presenting with hydrocephalus. J NEUROL NEUROSUR PS 2009;80 (5):550-551 [PubMed]
Brouwer MC, Keizerweerd GD, de Gans J, Spanjaard L, van de Beek D, Community acquired Staphylococcus aureus meningitis in adults. SCAND J INFECT DIS 2009;41 (5):375-377 [PubMed]
Brouwer MC, van de Beek D, Genetics in meningococcal disease: one step beyond. CLIN INFECT DIS 2009;48 (5):595-597 [PubMed]
del Pozo JL, van de Beek D, Daly RC, Pulido JS, McGregor CGA, Patel R, Incidence and clinical characteristics of ocular infections after heart transplantation: a retrospective cohort study. CLIN TRANSPLANT 2009;23 (4):484-489 [PubMed]
Engelen M, Nederkoorn PJ, Smits M, van de Beek D, Delayed life-threatening subdural hematoma after minor head injury in a patient with severe coagulopathy: a case report. CASES J 2009;2:7587 [PubMed]
Fenollar F, Rolain JM, Alric L, Papo T, Chauveheid MP, van de Beek D, Raoult D, Resistance to trimethoprim/sulfamethoxazole and Tropheryma whipplei. INT J ANTIMICROB AG 2009;34 (3):255-259 [PubMed]
Fransen F, Heckenberg SGB, Hamstra HJ, Feller M, Boog CJP, van Putten JPM, van de Beek D, van der Ende A, van der Ley P, Naturally Occurring Lipid A Mutants in Neisseria meningitidis from Patients with Invasive Meningococcal Disease Are Associated with Reduced Coagulopathy. PLOS PATHOG 2009;5 (4):e1000396 [PubMed]
Ganiem AR, Parwati I, Wisaksana R, van der Zanden A, van de Beek D, Sturm P, van der Ven A, Alisjahbana B, Brouwer AM, Kurniani N, de Gans J, van Crevel R, The effect of HIV infection on adult meningitis in Indonesia: a prospective cohort study. AIDS 2009;23 (17):2309-2316 [PubMed]
Geldhoff M, Mook-Kanamori BB, van de Beek D, Macrophage migration inhibitory factor, infection, the brain, and corticosteroids. CRIT CARE 2009;13 (4):170 [PubMed]
Mateen FJ, van de Beek D, Kremers WK, Daly RC, Edwards BS, McGregor CGA, Wijdicks EFM, Neuromuscular diseases after cardiac transplantation. J HEART LUNG TRANSPL 2009;28 (3):226-230 [PubMed]
Mook-Kanamori BB, Rouse MS, Kang CI, van de Beek D, Steckelberg JM, Patel R, Daptomycin in experimental murine pneumococcal meningitis. BMC INFECT DIS 2009;9:50 [PubMed]
Mook-Kanamori B, van de Beek D, Wijdicks EFM, Herpes simplex encephalitis with normal initial cerebrospinal fluid examination. J AM GERIATR SOC 2009;57 (8):1514-1515 [PubMed]
Schut ES, Brouwer MC, de Gans J, Florquin S, Troost D, van de Beek D, Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis. NEUROLOGY 2009;73 (23):1988-1995 [PubMed]
Schut ES, Westendorp WF, de Gans J, Kruyt ND, Spanjaard L, Reitsma JB, van de Beek D, Hyperglycemia in bacterial meningitis: a prospective cohort study. BMC INFECT DIS 2009;9 (1):57 [PubMed]
Tunkel AR, van de Beek D, Scheld WM. Acute meningitis in: Mandell GL, Bennett JE, Dolin R, editors. Principles and practices of infectious diseases. Philadelphia: Churchill Livingstone; 2009., p. 1189-1230
van de Beek D, Corticosteroids for acute adult bacterial meningitis. MED MALADIES INFECT 2009;39 (7-8):531-538 [PubMed]
van de Beek D. Hoofdpijn en koorts in: van Gijn J, van Dijk GW, editors. Probleemgeoriënteerd denken in de neurologie. Utrecht: De Tijdstroom; 2009., p. 151-159
van de Beek D, Kremers WK, Kushwaha SS, McGregor CGA, Wijdicks EFM, No major neurologic complications with sirolimus use in heart transplant recipients. MAYO CLIN PROC 2009;84 (4):330-332 [PubMed]
van de Beek D, Wijdicks EFM, Vermeij FH, de Haan RJ, Prins JM, Spanjaard L, Dippel DWJ, Nederkoorn PJ, Preventive Antibiotics for Infections in Acute Stroke A Systematic Review and Meta-analysis. ARCH NEUROL-CHICAGO 2009;66 (9):1076-1081 [PubMed]
[Contributors: Stahl JP, Duval X, Bingen E, de Broucker T, Bru JP, Decazes JM, Floret D, Lefort A, Lestavel P, Pessey JJ, Roblot F, Wolff M, Raffi F, Cambau E, Garré M, Gaudelus J, Guery B, Guillot M, Le Moing V, Martinez-Almoyna L, Moulin F, Raymond J, Taboulet P, Tardieu M, Tattevin P, Veyssier P, Béquet D, Chavanet P, des Portes V, Di Maio M, Grimprel E, Hoen B, Klossek JM, Levy C, Lucht F, Mercier JC, Michelet C, Sarlangue J, Stahl JP, Tulkens P, van Bambeke F, van de Beek D, Varon E, Vu-Thien H, Ansart S, Carbonnelle E, Dubos F, Forestier E, Haas H, Mourvillier B]] , Prise en charge des méningites bactériennes aiguës communautaires (a l'exclusion du nouveau-ne) Texte court - novembe 2008. REV NEUROL-FRANCE 2009;165 Spec No 3:F205-F216 [PubMed]
Brouwer MC, de Gans J, Heckenberg SGB, Kuiper H, van Lieshout HBM, van de Beek D, Vertebral osteomyelitis complicating pneumococcal meningitis. NEUROLOGY 2008;71 (8):612-613 [PubMed]
Fitch MT, van de Beek D, Drug Insight: steroids in CNS infectious diseases--new indications for an old therapy. NAT CLIN PRACT NEURO 2008;4 (2):97-104 [PubMed]
Heckenberg SGB, de Gans J, Brouwer MC, Weisfelt M, Piet JR, Spanjaard L, van der Ende A, van de Beek D, Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study. MEDICINE 2008;87 (4):185-192 [PubMed]
Schut ES, de Gans J, van de Beek D, Community-acquired bacterial meningitis in adults. PRACT NEUROL 2008;8 (1):8-23 [PubMed]
van de Beek D, de Gans J. Bacterial Meningitis in: Heggenhougen K, Quah S, editors. International Encyclopedia of Public Health : Vol. 6. San Diego: Academic Press; 2008., p. 330-334
van de Beek D, de Gans J, Should adults with suspected bacterial meningitis receive adjunctive dexamethasone?. NAT CLIN PRACT NEURO 2008;4 (5):252-253 [PubMed]
van de Beek D, Kremers W, Daly RC, Edwards BS, Clavell AL, McGregor CGA, Wijdicks EFM, The impact of neurologic complications on outcome after heart transplantation. ARCH NEUROL-CHICAGO 2008;65 (2):226-231 [PubMed]
van de Beek D, Kremers WK, del Pozo JL, Daly RC, Edwards BS, McGregor CGA, Patel R, Effect of infectious diseases on outcome after heart transplant. MAYO CLIN PROC 2008;83 (3):304-308 [PubMed]
van de Beek D, Patel R, Campeau NG, Badley A, Parisi JE, Rabinstein AA, Manno EM, Wijdicks EFM, Insidious sinusitis leading to catastrophic cerebral aspergillosis in transplant recipients. NEUROLOGY 2008;70 (24 Part 2):2411-2413 [PubMed]
van de Beek D, Rabinstein AA, Peters SG, Cloft H, Wijdicks EFM, Staphylococcus endocarditis associated with infectious vasculitis and recurrent cerebral hemorrhages. NEUROCRIT CARE 2008;8 (1):48-52 [PubMed]
van de Beek D, Spanjaard L, de Gans J, Streptococcus suis meningitis in the Netherlands. J INFECTION 2008;57 (2):158-161 [PubMed]
van de Beek D, Weisfelt M, de Gans J. Bacterial Meningitis in: Waldman SA, Terzic A, editors. Pharmacology and Therapeutics; Principles to Practices. 1st ed. Philadelphia, USA. Philadelphia: Saunders Elsevier; 2008., p. 1109-1121
van de Beek D, Wijdicks EFM, Abnormal conscious state and coma in transplant recipients. HANDB CLIN NEUROL 2008;90:283-293 [PubMed]
Weerkamp N, van de Beek D, de Gans J, Koehler PJ, Herpes reactivation in patients with bacterial meningitis. J INFECTION 2008;57 (6):493-494 [PubMed]
Weisfelt M, van de Beek D, Role of Coagulation in Predicting the Outcome of Bacterial Meningitis Reply. ANN NEUROL 2008;64 (4):474
Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J, A risk score for unfavorable outcome in adults with bacterial meningitis. ANN NEUROL 2008;63 (1):90-97 [PubMed]
Zoons E, Weisfelt M, de Gans J, Spanjaard L, Koelman JHTM, Reitsma JB, van de Beek D, Seizures in adults with bacterial meningitis. NEUROLOGY 2008;70 (22 Part 2):2109-2115 [PubMed]
Adriani KS, van de Beek D, Brouwer MC, Spanjaard L, de Gans J, Community-acquired recurrent bacterial meningitis in adults. CLIN INFECT DIS 2007;45 (5):e46-e51 [PubMed]
Brouwer MC, van de Beek D, Heckenberg SGB, Spanjaard L, de Gans J, Community-acquired Haemophilus influenzae meningitis in adults. CLIN MICROBIOL INFEC 2007;13 (4):439-442 [PubMed]
Brouwer MC, van de Beek D, Heckenberg SGB, Spanjaard L, de Gans J, Hyponatraemia in adults with community-acquired bacterial meningitis. QJM-INT J MED 2007;100 (1):37-40 [PubMed]
Fitch MT, van de Beek D, Emergency diagnosis and treatment of adult meningitis. LANCET INFECT DIS 2007;7 (3):191-200 [PubMed]
Hoogman M, van de Beek D, Weisfelt M, de Gans J, Schmand B, Cognitive outcome in adults after bacterial meningitis. J NEUROL NEUROSUR PS 2007;78 (10):1092-1096 [PubMed]
Majoie CBLM, van Boven LJ, van de Beek D, Venema HW, van Rooij WJ, Perfusion CT to evaluate the effect of transluminal angioplasty on cerebral perfusion in the treatment of vasospasm after subarachnoid hemorrhage. NEUROCRIT CARE 2007;6 (1):40-44 [PubMed]
van de Beek D, Brain teasing effect of dexamethasone. LANCET NEUROL 2007;6 (3):203-204 [PubMed]
van de Beek D, Brouwer M, de Gans J, Hypernatremia in bacterial meningitis. J INFECTION 2007;55 (4):381-382 [PubMed]
van de Beek D, Campeau NG, Wijdicks EFM, The clinical challenge of recognizing infratentorial empyema. NEUROLOGY 2007;69 (5):477-481 [PubMed]
van de Beek D, de Gans J, Therapy in postpuncture meningitis. ANESTHESIOLOGY 2007;106 (4):876-7; author reply 881 [PubMed]
van de Beek D, de Gans J, McIntyre P, Prasad K, Corticosteroids for acute bacterial meningitis. COCHRANE DB SYST REV 2007;2007 (1):CD004405 [PubMed]
van de Beek D, Patel R, Daly RC, McGregor CGA, Wijdicks EFM, Central nervous system infections in heart transplant recipients. ARCH NEUROL-CHICAGO 2007;64 (12):1715-1720 [PubMed]
van de Beek D, Patel R, Wijdicks EFM, Meningococcal meningitis with brainstem infarction. ARCH NEUROL-CHICAGO 2007;64 (9):1350-1351 [PubMed]
van de Beek D, Steckelberg JM, Marshall WF, Kijpittayarit S, Wijdicks EFM, Tularemia with brain abscesses. NEUROLOGY 2007;68 (7):531 [PubMed]
Weisfelt M, de Gans J, van de Beek D, Bacterial meningitis: a review of effective pharmacotherapy. EXPERT OPIN PHARMACO 2007;8 (10):1493-1504 [PubMed]
Weisfelt M, Determann RM, de Gans J, van der Ende A, Levi M, van de Beek D, Schultz MJ, Procoagulant and fibrinolytic activity in cerebrospinal fluid from adults with bacterial meningitis. J INFECTION 2007;54 (6):545-550 [PubMed]
Weisfelt M, van de Beek D, de Gans J, Community-acquired bacterial meningitis in older people - Response. J AM GERIATR SOC 2007;55 (4):629-630
Weisfelt M, van de Beek D, Spanjaard L, de Gans J, Nosocomial bacterial meningitis in adults: a prospective series of 50 cases. J HOSP INFECT 2007;66 (1):71-78 [PubMed]
Brouwer MC, van de Beek D, Heckenberg SGB, Spanjaard L, de Gans J, Community-acquired Listeria monocytogenes meningitis in adults. CLIN INFECT DIS 2006;43 (10):1233-1238 [PubMed]
Determann RM, Weisfelt M, de Gans J, van der Ende A, Schultz MJ, van de Beek D, Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. INTENS CARE MED 2006;32 (8):1243-1247 [PubMed]
van de Beek D, Community-acquired bacterial meningitis - Reply. NEW ENGL J MED 2006;354 (13):1431-1432
van de Beek D, de Gans J, Dexamethasone in adults with community-acquired bacterial meningitis. DRUGS 2006;66 (4):415-427 [PubMed]
van de Beek D, de Gans J, Tunkel AR, Wijdicks EFM, Community-acquired bacterial meningitis in adults. NEW ENGL J MED 2006;354 (1):44-53 [PubMed]
van de Beek D, Weisfelt M, de Gans J, Tunkel AR, Wijdicks EFM, Drug Insight: adjunctive therapies in adults with bacterial meningitis. NAT CLIN PRACT NEURO 2006;2 (9):504-516 [PubMed]
van de Beek D, Weisfelt M, Hoogman M, de Gans J, Schmand B, Neuropsychological sequelae of bacterial meningitis: the influence of alcoholism and adjunctive dexamethasone therapy. BRAIN 2006;129 (Part 5):E46; author reply E47-U1 [PubMed]
Weisfelt M, de Gans J, van der Poll T, van de Beek D, Pneumococcal meningitis in adults: new approaches to management and prevention. LANCET NEUROL 2006;5 (4):332-342 [PubMed]
Weisfelt M, Hoogman M, van de Beek D, de Gans J, Dreschler WA, Schmand BA, Dexamethasone and long-term outcome in adults with bacterial meningitis. ANN NEUROL 2006;60 (4):456-468 [PubMed]
Weisfelt M, van de Beek D, de Gans J, Dexamethasone treatment in adults with pneumococcal meningitis: risk factors for death. EUR J CLIN MICROBIOL 2006;25 (2):73-78 [PubMed]
Weisfelt M, van de Beek D, de Haan RJ, de Gans J, Dexamethasone and prognostic factors in adults with bacterial meningitis. J NEUROL 2006;253 (5):570-573 [PubMed]
Weisfelt M, van de Beek D, Hoogman M, Hardeman C, de Gans J, Schmand B, Cognitive outcome in adults with moderate disability after pneumococcal meningitis. J INFECTION 2006;52 (6):433-439 [PubMed]
Weisfelt M, van de Beek D, Spanjaard L, de Gans J, Arthritis in adults with community-acquired bacterial meningitis: a prospective cohort study. BMC INFECT DIS 2006;6:64 [PubMed]
Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J, Attenuated cerebrospinal fluid leukocyte count and sepsis in adults with pneumococcal meningitis: a prospective cohort study. BMC INFECT DIS 2006;6:149 [PubMed]
Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J, Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. LANCET NEUROL 2006;5 (2):123-129 [PubMed]
Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J, Community-acquired bacterial meningitis in older people. J AM GERIATR SOC 2006;54 (10):1500-1507 [PubMed]
van de Beek D, de Gans J, Adjunctive Corticosteroids in Adults with Bacterial Meningitis. CURR INFECT DIS REP 2005;7 (4):285-291 [PubMed]
van de Beek D, de Gans J, Prognostic factors in adults with bacterial meningitis - Reply. NEW ENGL J MED 2005;352 (5):514
van de Beek D. Bacterial meningitis in adults. S.l.: s.n.; 2004. 143p. ISBN - [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Vermeulen M; copromotor(s): )
van de Beek D, de Gans J, Dexamethasone and pneumococcal meningitis. ANN INTERN MED 2004;141 (4):327 [PubMed]
van de Beek D, de Gans J, Meningitis-associated hearing loss: Protection by adjunctive antioxidant therapy. ANN NEUROL 2004;55 (4):597-598 [PubMed]
van de Beek D, de Gans J, McIntyre P, Prasad K, Steroids in adults with acute bacterial meningitis: a systematic review. LANCET INFECT DIS 2004;4 (3):139-143 [PubMed]
van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M, Clinical features and prognostic factors in adults with bacterial meningitis. NEW ENGL J MED 2004;351 (18):1849-1859 [PubMed]
de Gans J, van de Beek D, Dexamethasone in adults with bacterial meningitis - Reply. NEW ENGL J MED 2003;348 (10):955-956
van de Beek D, de Gans J, McIntyre P, Prasad K, Corticosteroids in acute bacterial meningitis. COCHRANE DB SYST REV 2003;2003 (3):CD004405 [PubMed]
de Gans J, van de Beek D, Dexamethasone in adults with bacterial meningitis. NEW ENGL J MED 2002;347 (20):1549-1556 [PubMed]
de Gans J, van de Beek D, Dexamethason gunstig bij volwassenen met acute bacteriële meningitis: een gerandomiseerd placebogecontroleerd onderzoek. NED TIJDSCHR GENEESKD 2002;146 (47):2235-2240
van de Beek D, de Gans J, Spanjaard L, Sela S, Vermeulen M, Dankert J, Group A streptococcal meningitis in adults: Report of 41 cases and a review of the literature. CLIN INFECT DIS 2002;34 (9):E32-E36 [PubMed]
van de Beek D, de Gans J, Spanjaard L, Vermeulen M, Dankert J, Antibiotic guidelines and antibiotic use in adult bacterial meningitis in The Netherlands. J ANTIMICROB CHEMOTH 2002;49 (4):661-666 [PubMed]
van de Beek D, Schmand B, de Gans J, Weisfelt M, Vaessen H, Dankert J, Vermeulen M, Cognitive impairment in adults with good recovery after bacterial meningitis. J INFECT DIS 2002;186 (7):1047-1052 [PubMed]
Drogari-Apiranthitou M, Fijen CA, van de Beek D, Hensen EF, Dankert J, Kuijper EJ, Development of antibodies against tetravalent meningococcal polysaccharides in revaccinated complement-deficient patients. CLIN EXP IMMUNOL 2000;119 (2):311-316 [PubMed]
Houben MH, van de Beek D, Hensen EF, Craen AJ, Rauws EA, Tytgat GN, A systematic review of Helicobacter pylori eradication therapy--the impact of antimicrobial resistance on eradication rates. ALIMENT PHARM THER 1999;13 (8):1047-1055 [PubMed]
Houben MH, van de Beek D, Hensen EF, de Craen AJ, van 't Hoff BW, Tytgat GN, Helicobacter pylori eradication therapy in The Netherlands. SCAND J GASTROENTERO 1999;230 (Suppl.):17-22 [PubMed]
van de Beek D, Hensen EF, Spanjaard L, de Gans J, Enting RH, Dankert J, Meropenem susceptibility of Neisseria meningitidis and Streptococcus pneumoniae from meningitis patients in The Netherlands. J ANTIMICROB CHEMOTH 1997;40 (6):895-897 [PubMed]
Enting RH, Spanjaard L, van de Beek D, Hensen EF, de Gans J, Dankert J, Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994. J ANTIMICROB CHEMOTH 1996;38 (5):777-786 [PubMed]
Key publications

van de Beek D, Brouwer MC, Thwaites GE, Tunkel AR, Advances in treatment of bacterial meningitis. LANCET 2012;380 (9854):1693-1702 [PubMed]
McIntyre PB, O'Brien KL, Greenwood B, van de Beek D, Effect of vaccines on bacterial meningitis worldwide. LANCET 2012;380 (9854):1703-1711 [PubMed]
Brouwer MC, Tunkel AR, McKhann GM 2nd, van de Beek D, Brain Abscess. NEW ENGL J MED 2014;371 (5):447-456 [PubMed]
Westendorp WF, Vermeij JD, Zock E, Hooijenga IJ, Kruyt ND, Bosboom HJLW, Kwa VIH, Weisfelt M, Remmers MJM, ten Houten R, Schreuder AHCMT, Vermeer SE, van Dijk EJ, Dippel DWJ, Dijkgraaf MGW, Spanjaard L, Vermeulen M, van der Poll T, Prins JM, Vermeij FH, Roos YBWEM, Kleyweg RP, Kerkhoff H, Brouwer MC, Zwinderman AH, van de Beek D, Nederkoorn PJ [Contributors: van de Beek D, Nederkoorn PJ, Westendorp WF , Vermeij JD, Kerkhoff H, Zock E, Kleyweg RP, Bosboom JLW, Kwa VIH, Weisfelt M, Kruyt ND, Remmers MJM, van Dijk EJ, Vermeij F, Schreuder A, Vermeer SE, ten Houten R, Dippel DWJ, Kappelle LJ, van der Worp HB, Merkies ISJ, de Bruijn SFTM, de Laat KF, Haag D, Jellema K, Keizer K, de Rijk MC, Vermeij AJ, Visser MC, Aerden LAM, Schut ES, Reichman LJA, de Gans K, van den Berg-Vos RM, van Goor MPJ, Wijnhoud AD, van der Ree TC, Janmaat M, van Orshoven N, Manschot SM, Dijkgraaf MGW, van der Poll T, Prins JM, Spanjaard L, Vermeij FH]] , The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial. LANCET 2015;385 (9977):1519-1526 [PubMed]
Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D, Community-acquired bacterial meningitis in adults in the Netherlands, 2006-14: a prospective cohort study. LANCET INFECT DIS 2016;16 (3):339-347 [PubMed]


All Publications

Curriculum Vitae
2012- Professor of neurology
2007- Neurologist, Group leader neurological infection and inflammation, Department of Neurology, Center for Infection and Immunity, University of Amsterdam
2006-2007Neurologist, Mayo Clinic, Rochester, USA
2000-2006 Board Certification Neurology, Academic Medical Center, Amsterdam
1998-2004 Doctorate (Ph.D.), “Bacterial meningitis in adults”, University of Amsterdam
1992-1999 Medical Degree (M.D.) 
Faculty of Medicine, University of Amsterdam
Research programmes

Neuroinfection and Inflammation

Bacterial meningitis. In 2002, we completed a study on the life-saving effect of adjunctive dexamethasone therapy in bacterial meningitis. Subsequently, we identified defining factors in the prognosis of this devastating disease in the largest cohort study to date. We translated research results to clinical practice in papers on the management of meningitis. MeninGene is a nationwide project on genetic traits that may support the susceptibility to severe forms of bacterial meningitis. 

Encephalitis. Recently, we completed the PACEM study. In this prospective cohort study we aim to systematically determine the causes of meningitis and encephalitis in children and adults with suspected bacterial meningitis, and describe clinical and laboratory findings in these patients.

Neurosarcoidosis. Neurosarcoidosis a condition of unknown cause featuring granulomas in various tissues, involving the central nervous system (brain and spinal cord). In a prospective cohort study we evaluate clinical characteristics, genetic background, treatment and outcome of this disease. 

Infections after stroke. Stroke is a leading cause of death worldwide. Fever after stroke is a strong predictor of a poor outcome. Infections occur in up to 40% of patients with stroke and have also been associated with poor outcomes. In 2015, results were published of the Preventive Antibiotics in Stroke Study (PASS) on preventive use of the antibiotic ceftriaxone iin patients with acute stroke. Currently, we are particpating in the PRECIOUS project.

Septic encephalopathy. Experimental findings and neuropathological observations suggest that activation of microglia is pivotal for mediation of the behavioural effects of systemic infections. The microglial response is usually regulated tightly, but defensive features could turn neurotoxic once microglial cells escape from cholinergic inhibition. In a prospective autopsy study and animals models we evaluate the role of microglial activation in sepsis associated encephalopathy.

Inflammatory diseases of peripheral nerves and muscles. The immune mediated neuropathies (e.g. GBS, CIDP, MMN) and myopathies (e.g. dermatomysositis, IBM) and critical illness neuropathy and myopathy are the specific diseases of interest. Clinical trials, cohort studies and studies investigating immunological and genomic characterization of nerve and muscle inflammation are performed. From these studies we try to arrive at clinically relevant biomarkers of disease activity and predictors of response. 

Faculty
Prof. D. van de Beek MD PhD
Dr. M.C. Brouwer MD PhD
Dr. F. Eftimov MD PhD
Dr. A.J. van der Kooi MD
Prof. dr. I.N. van Schaik
Dr. C. Verhamme MD
Prof. dr. M. de Visser

Postdocs
Dr. M.W. Bijlsma MD PhD
Dr. E.B. Ferwerda PhD
Dr. M. Valls Serón
Dr. L. Wieske MD PhD

PhD Students
Drs. J.M. Costerus
Drs. K.R.I.S. Dorresteijn MD
Drs. J.Y. Engelen-Lee MD
C.N. van Ettekoven
D. Fritz
Drs. I.C.M. Hoogland
K.K. Jim MD
Drs. E.S. Kasanmoentalib MD
M.N. van Kassel
H.N. Khan MSc
Drs. A.T. Kloek MD
Drs. M.M. Koopmans MD
P.H.C. Kremer MD
Drs. K.E.B. van Veen MD
Drs. J.D. Vermeij MD
Drs. W.F. Westendorp MD
Drs. D. Westhoff MD
I.E. van Zeggeren
E. Zock MSc (Albert Schweitzer ziekenhuis)
Drs. M.E. Adrichem
Drs. E. Beeldman MD PhD
Drs. B.W. van Paassen
Drs. S.M. Schade van Westrum MD (Martini Ziekenhuis Groningen)
Drs. E.S. Schut MD (Martini Ziekenhuis)
Drs. E. Witteveen MD

Others
J. Gibson
S. Gouda BA
Ing. V. Jaspers
Drs. W.K. Man MSc

Other research related activities
  • Contribution to guidelines and protocols, Dutch Bacterial Meningitis Guidelines
  • Contribution to guidelines and protocols, Dutch Lyme Disease Guidelines
  • Contribution to guidelines and protocols, Dutch Antibiotic Guidelines in Neurological Disorders
  • Membership of editorial board / Editorship, BMC INFECTIOUS DISEASES
  • Membership of editorial board / Editorship, COCHRANE DATABASE OF SYSTEMATIC REVIEWS
  • Contribution to guidelines and protocols, IDSA guideline - Nosocomial Meningitis
  • Coordinator Clinical Series Meningitis, Lancet
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • CSL Behring LLC
  • Eli Lilly and Company
  • Europese Unie
  • GlaxoSmithKline Biologicals SA
  • Medical Research BV
  • PHARNEXT
  • PPD Netherlands BV
  • Prinses Beatrix Spierfonds
  • ProPhase, LLC.
  • Quintiles B.V.
  • ZonMw