• Principal Investigator
  • Male

Prof. dr. E. Fliers

Position: Professor
Main activities: Patient care, Research, Teaching
Specialisation: Internal medicine, endocrinology
foto E. Fliers is one of the AMC Principal Investigators
Focus of research:
  • Hypothalamus-pituitary-thyroid axis
  • Role of hypothalamus in neuro-endocrine regulation of metabolism
  • Neuro-endocrine response to (psychiatric) illness
AMC themes: Metabolic disorders and gastrointestinal diseases, Neurological & Psychiatric Disorders
Departments: Internal Medicine: Endocrinology
Boelen A, van der Spek AH, Bloise F, de Vries EM, Surovtseva OV, van Beeren M, Ackermans MT, Kwakkel J, Fliers E, Tissue thyroid hormone metabolism is differentially regulated during illness in mice. J ENDOCRINOL 2017;233 (1):25-36 [PubMed]
Diepenbroek C. Glucose Metabolism, Diet Composition, and the Brain. S.l.: s.n.; 2017. 221p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Kalsbeek A; copromotor(s): La Fleur SE, Serlie MJ)
Diepenbroek C, Eggels L, Ackermans MT, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE, Differential effects of hypercaloric choice diets on insulin sensitivity in rats. J ENDOCRINOL 2017;232 (1):49-57 [PubMed]
Diepenbroek C, Rijnsburger M, Eggels L, van Megen KM, Ackermans MT, Fliers E, Kalsbeek A, Serlie MJ, La Fleur SE, Infusion of fluoxetine, a serotonin reuptake inhibitor, in the shell region of the nucleus accumbens increases blood glucose concentrations in rats. NEUROSCI LETT 2017;637:85-90 [PubMed]
Opperhuizen AL, Stenvers DJ, Jansen RD, Foppen E, Fliers E, Kalsbeek A, Light at night acutely impairs glucose tolerance in a time-, intensity- and wavelength-dependent manner in rats. DIABETOLOGIA 2017;60 (7):1333-1343 [PubMed]
Stenvers DJ. Light, the circadian timing system, and type 2 diabetes. S.l.: s.n.; 2017. 219p. ISBN 978-94-028-0545-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Kalsbeek A; copromotor(s): Bisschop PHLT)
van Brussel PM, van den Bogaard B, de Weijer BA, Truijen J, Krediet CTP, Janssen IM, van de Laar A, Kaasjager K, Fliers E, van Lieshout JJ, Serlie MJ, van den Born BJH, Blood pressure reduction after gastric bypass surgery is explained by a decrease in cardiac output. J APPL PHYSIOL 2017;122 (2):223-229 [PubMed]
van der Spek AH, Fliers E, Boelen A, The classic pathways of thyroid hormone metabolism. MOL CELL ENDOCRINOL 2017;ahead of print [PubMed]
van der Spek AH, Fliers E, Boelen A, Thyroid hormone metabolism in innate immune cells. J ENDOCRINOL 2017;232 (2):R67-R81 [PubMed]
van der Spek AH, Surovtseva OV, Aan S, Tool ATJ, van de Geer A, Demir K, van Gucht ALM, van Trotsenburg ASP, van den Berg TK, Fliers E, Boelen A, Increased circulating interleukin-8 in patients with resistance to thyroid hormone receptor α. ENDOCR CONNECT 2017;6 (8):731-740 [PubMed]
Versteeg RI. Brain, nutrition and metabolism: Studies in lean, obese and insulin resistant humans. S.l.: s.n.; 2017. 239p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E; copromotor(s): La Fleur SE, Serlie MJ)
Versteeg RI, Ackermans MT, Nederveen AJ, Fliers E, Serlie MJ, La Fleur SE, Meal timing effects on insulin sensitivity and intrahepatic triglycerides during weight loss. INT J OBESITY 2017;ahead of print [PubMed]
Versteeg RI, Koopman KE, Booij J, Ackermans MT, Unmehopa UA, Fliers E, la Fleur SE, Serlie MJ, Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans. NEUROENDOCRINOLOGY 2017;105 (2):141-149 [PubMed]
Versteeg RI, Schrantee A, Adriaanse SM, Unmehopa UA, Booij J, Reneman L, Fliers E, la Fleur SE, Serlie MJ, Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding. FASEB J 2017;31 (10):4545-4554 [PubMed]
Versteeg RI, Stenvers DJ, Visintainer D, Linnenbank A, Tanck MW, Zwanenburg G, Smilde AK, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE, Bisschop PH, Acute Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and Men with Type 2 Diabetes. J BIOL RHYTHM 2017;32 (2):130-142 [PubMed]
Zhang Z. Hypothalamic regulation of metabolism: Role of thyroid hormone and estrogen. S.l.: s.n.; 2017. 164p. ISBN 978-94-6332-112-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Kalsbeek A; copromotor(s): Bisschop PHLT, Boelen A)
Zhang Z, Boelen A, Bisschop PH, Kalsbeek A, Fliers E, Hypothalamic effects of thyroid hormone. MOL CELL ENDOCRINOL 2017;ahead of print [PubMed]
Zwaveling-Soonawala N, Maas SM, Alders M, Majoie CB, Fliers E, van Trotsenburg ASP, Hennekam RCM, Variants in KAT6A and pituitary anomalies. AM J MED GENET A 2017;173 (9):2562-2565 [PubMed]
Zwaveling-Soonawala N, Witteveen ME, Marchal JP, Klouwer FCC, Ikelaar NA, Smets AMJB, van Rijn RR, Endert E, Fliers E, van Trotsenburg ASP, Early thyroxine treatment in Down syndrome and thyroid function later in life. EUR J ENDOCRINOL 2017;176 (5):505-513 [PubMed]
Bloise FF, van der Spek AH, Surovtseva OV, Ortiga-Carvalho TM, Fliers E, Boelen A, Differential Effects of Sepsis and Chronic Inflammation on Diaphragm Muscle Fiber Type, Thyroid Hormone Metabolism, and Mitochondrial Function. THYROID 2016;26 (4):600-609 [PubMed]
de Koning PP, Figee M, Endert E, van den Munckhof P, Schuurman PR, Storosum JG, Denys D, Fliers E, Rapid effects of deep brain stimulation reactivation on symptoms and neuroendocrine parameters in obsessive-compulsive disorder. TRANSL PSYCHIAT 2016;6:e722 [PubMed]
de Vries EM, Nagel S, Haenold R, Sundaram SM, Pfrieger FW, Fliers E, Heuer H, Boelen A, The Role of Hypothalamic NF-κB Signaling in the Response of the HPT-Axis to Acute Inflammation in Female Mice. ENDOCRINOLOGY 2016;157 (7):2947-2956 [PubMed]
de Weijer BAM. An obese brain and an inflamed body: Central and peripheral consequences of obesity. S.l.: s.n.; 2016. 161p. ISBN 978-94-6295-322-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E; copromotor(s): Serlie MJM, van Eijk MC)
Elbers L. Endocrine determinants of haemostasis and thrombosis risk: Focus on thyroid hormone. S.l.: s.n.; 2016. 281p. ISBN 978-94-6233-407-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Brandjes DPM, Fliers E; copromotor(s): Gerdes VEA, Cannegieter SC)
Elbers LPB, Boon HA, Moes MI, van Zaane B, Brandjes DPM, Fliers E, Büller HR, Cannegieter S, Gerdes VEA, Plasma Levels of Free Thyroxine and Risk of Major Bleeding in Bariatric Surgery. EUR THYROID J 2016;5 (2):139-144 [PubMed]
Elbers LPB, Moran C, Gerdes VEA, van Zaane B, Meijers JCM, Endert E, Lyons G, Chatterjee VK, Bisschop PH, Fliers E, The Hypercoagulable state in Hyperthyroidism is mediated via the Thyroid Hormone β Receptor pathway. EUR J ENDOCRINOL 2016;174 (6):755-762 [PubMed]
Foppen E, Tan AAT, Ackermans MT, Fliers E, Kalsbeek A, Suprachiasmatic Nucleus Neuropeptides and Their Control of Endogenous Glucose Production. J NEUROENDOCRINOL 2016;ahead of print [PubMed]
Heinen CA, Jongejan A, Watson PJ, Redeker B, Boelen A, Boudzovitch-Surovtseva O, Forzano F, Hordijk R, Kelley R, Olney AH, Pierpont ME, Schaefer GB, Stewart F, van Trotsenburg ASP, Fliers E, Schwabe JWR, Hennekam RC, A specific mutation in TBL1XR1 causes Pierpont syndrome. J MED GENET 2016;53 (5):330-337 [PubMed]
Heinen CA, Losekoot M, Sun Y, Watson PJ, Fairall L, Joustra SD, Zwaveling-Soonawala N, Oostdijk W, van den Akker ELT, Alders M, Santen GWE, van Rijn RR, Dreschler WA, Surovtseva OV, Biermasz NR, Hennekam RC, Wit JM, Schwabe JWR, Boelen A, Fliers E, van Trotsenburg ASP, Mutations in TBL1X Are Associated With Central Hypothyroidism. J CLIN ENDOCR METAB 2016;101 (12):4564-4573 [PubMed]
Joustra SD, Andela CD, Oostdijk W, van Trotsenburg ASP, Fliers E, Wit JM, Pereira AM, Middelkoop HAM, Biermasz NR, Mild deficits in attentional control in patients with the IGSF1 deficiency syndrome. CLIN ENDOCRINOL 2016;84 (6):896-903 [PubMed]
Joustra SD, Heinen CA, Schoenmakers N, Bonomi M, Ballieux BEPB, Turgeon MO, Bernard DJ, Fliers E, van Trotsenburg ASP, Losekoot M, Persani L, Wit JM, Biermasz NR, Pereira AM, Oostdijk W, IGSF1 Deficiency: Lessons From an Extensive Case Series and Recommendations for Clinical Management. J CLIN ENDOCR METAB 2016;101 (4):1627-1636 [PubMed]
Joustra SD, Roelfsema F, Endert E, Ballieux BEPB, van Trotsenburg ASP, Fliers E, Corssmit EPM, Bernard DJ, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Pituitary Hormone Secretion Profiles in IGSF1 Deficiency Syndrome. NEUROENDOCRINOLOGY 2016;103 (3-4):408-416 [PubMed]
Koopman KE, Roefs A, Elbers DCE, Fliers E, Booij J, Serlie MJ, La Fleur SE, Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men. PSYCHOL MED 2016;46 (8):1707-1717 [PubMed]
Limonard EJ. Interaction between bone, the neuroendocrine system and metabolism. S.l.: s.n.; 2016. 178p. ISBN 978-90-9029568-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E; copromotor(s): Bisschop PHLT)
Limonard EJ, Schoenmaker T, de Vries TJ, Tanck MW, Heijboer AC, Endert E, Fliers E, Everts V, Bisschop PH, Clonidine increases bone resorption in humans. OSTEOPOROSIS INT 2016;27 (3):1063-1071 [PubMed]
Opperhuizen AL, Wang D, Foppen E, Jansen R, Boudzovitch-Surovtseva O, de Vries J, Fliers E, Kalsbeek A, Feeding during the resting phase causes profound changes in physiology and desynchronization between liver and muscle rhythms of rats. EUR J NEUROSCI 2016;44 (10):2795-2806 [PubMed]
Stenvers DJ, van Dorp R, Foppen E, Mendoza J, Opperhuizen AL, Fliers E, Bisschop PH, Meijer JH, Kalsbeek A, Deboer T, Dim light at night disturbs the daily sleep-wake cycle in the rat. SCI REP-UK 2016;6:35662 [PubMed]
Su Y. Hypothalamic control of liver and white adipose tissue metabolism. S.l.: s.n.; 2016. 215p. ISBN 978-94-6182-730-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kalsbeek A, Fliers E; copromotor(s): )
Su Y, Cailotto C, Foppen E, Jansen R, Zhang Z, Buijs R, Fliers E, Kalsbeek A, The role of feeding rhythm, adrenal hormones and neuronal inputs in synchronizing daily clock gene rhythms in the liver. MOL CELL ENDOCRINOL 2016;422 (C):125-131 [PubMed]
Su Y, Foppen E, Fliers E, Kalsbeek A, Effects of Intracerebroventricular Administration of Neuropeptide Y on Metabolic Gene Expression and Energy Metabolism in Male Rats. ENDOCRINOLOGY 2016;157 (8):3070-3085 [PubMed]
Su Y, Foppen E, Zhang Z, Fliers E, Kalsbeek A, Effects of 6-meals-a-day feeding and 6-meals-a-day feeding combined with adrenalectomy on daily gene expression rhythms in rat epididymal white adipose tissue. GENES CELLS 2016;21 (1):6-24 [PubMed]
van der Spek AH, Bloise FF, Tigchelaar W, Dentice M, Salvatore D, van der Wel NN, Fliers E, Boelen A, The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils. ENDOCRINOLOGY 2016;157 (8):3293-3305 [PubMed]
van der Zwaal EM, de Weijer BA, van de Giessen EM, Janssen I, Berends FJ, van de Laar A, Ackermans MT, Fliers E, la Fleur SE, Booij J, Serlie MJ, Striatal dopamine D-2/3 receptor availability increases after long-term bariatric surgery-induced weight loss. EUR NEUROPSYCHOPHARM 2016;26 (7):1190-1200 [PubMed]
van Gucht ALM, Meima ME, Zwaveling-Soonawala N, Visser WE, Fliers E, Wennink JMB, Henny C, Visser TJ, Peeters RP, van Trotsenburg ASP, Resistance to Thyroid Hormone Alpha in an 18-Month-Old Girl: Clinical, Therapeutic, and Molecular Characteristics. THYROID 2016;26 (3):338-346 [PubMed]
van Rooijen G, Denys D, Fliers E, Nieuwdorp M, Effective Electroconvulsive Therapy in a Patient With Psychotic Depression With Active Cushing Disease. J ECT 2016;32 (3):e20-e21 [PubMed]
Vissenberg R. The influence of thyroid disorders on adverse pregnancy outcomes. S.l.: s.n.; 2016. 189p. ISBN 978-94-6299-306-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Post JAM, Fliers E; copromotor(s): Goddijn M, Bisschop PHLT)
Vissenberg R, Fliers E, van der Post JAM, van Wely M, Bisschop PH, Goddijn M, Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies. GYNECOL ENDOCRINOL 2016;32 (2):132-135 [PubMed]
Vissenberg R, Vrijkotte TGM, van der Post JAM, Fliers E, Goddijn M, Bisschop PH, Abnormal thyroid function parameters in the second trimester of pregnancy are associated with breech presentation at term: a nested cohort study. EUR J OBSTET GYN R B 2016;199:169-174 [PubMed]
Zhang Z, Bisschop PH, Foppen E, van Beeren HC, Kalsbeek A, Boelen A, Fliers E, A model for chronic, intrahypothalamic thyroid hormone administration in rats. J ENDOCRINOL 2016;229 (1):37-45 [PubMed]
Zhang Z, Foppen E, Su Y, Bisschop PH, Kalsbeek A, Fliers E, Boelen A, Metabolic Effects of Chronic T3 Administration in the Hypothalamic Paraventricular and Ventromedial Nucleus in Male Rats. ENDOCRINOLOGY 2016;157 (10):4076-4085 [PubMed]
Zhang Z, Liu J, Veldhuis-Vlug AG, Su Y, Foppen E, van der Eerden BCJ, Koedam M, Bravenboer N, Kalsbeek A, Boelen A, Fliers E, Bisschop PH, Effects of Chronic Estrogen Administration in the Ventromedial Nucleus of the Hypothalamus (VMH) on Fat and Bone Metabolism in Ovariectomized Rats. ENDOCRINOLOGY 2016;157 (12):4930-4942 [PubMed]
Bisschop PH, Fliers E, Kalsbeek A, Autonomic regulation of hepatic glucose production. COMPR PHYSIOL 2015;5 (1):147-165 [PubMed]
Bruinstroop E, Eliveld J, Foppen E, Busker S, Ackermans MT, Fliers E, Kalsbeek A, Hepatic denervation and dyslipidemia in obese Zucker (fa/fa) rats. INT J OBESITY 2015;39 (11):1655-1658 [PubMed]
de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E, The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia. ENDOCR CONNECT 2015;4 (2):86-91 [PubMed]
de Vries EM. Thyroid hormone metabolism during inflammation and fasting. S.l.: s.n.; 2015. 187p. ISBN 978-94-6259-597-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Kalsbeek A; copromotor(s): Boelen A)
de Vries EM, Fliers E, Boelen A, The molecular basis of the non-thyroidal illness syndrome. J ENDOCRINOL 2015;225 (3):R67-R81 [PubMed]
de Vries EM, van Beeren HC, Ackermans MT, Kalsbeek A, Fliers E, Boelen A, Differential effects of fasting vs food restriction on liver thyroid hormone metabolism in male rats. J ENDOCRINOL 2015;224 (1):25-35 [PubMed]
Fliers E, Bianco AC, Langouche L, Boelen A, Thyroid function in critically ill patients. LANCET DIABETES ENDO 2015;3 (10):816-825 [PubMed]
Kalsbeek A, Su Y, Fliers E, La Fleur SE. The hypothalamo-pituitary-adrenal axis: circadian dysregulation and obesity in: Russell JA, Shipston MJ, editors. Neuroendocrinology of Stress. S.l.: Wiley-Blackwell; 2015., p. 219-243
Limonard EJ, van Schoor NM, de Jongh RT, Lips P, Fliers E, Bisschop PH, Osteocalcin and the pituitary-gonadal axis in older men: a population-based study. CLIN ENDOCRINOL 2015;82 (5):753-759 [PubMed]
Limonard EJ, Veldhuis-Vlug AG, van Dussen L, Runge JH, Tanck MW, Endert E, Heijboer AC, Fliers E, Hollak CE, Akkerman EM, Bisschop PH, Short-Term Effect of Estrogen on Human Bone Marrow Fat. J BONE MINER RES 2015;30 (11):2058-2066 [PubMed]
Oosterman JE, Foppen E, van der Spek R, Fliers E, Kalsbeek A, la Fleur SE, Timing of fat and liquid sugar intake alters substrate oxidation and food efficiency in male Wistar rats. CHRONOBIOL INT 2015;32 (2):289-298 [PubMed]
Su Y, van der Spek R, Foppen E, Kwakkel J, Fliers E, Kalsbeek A, Effects of adrenalectomy on daily gene expression rhythms in the rat suprachiasmatic and paraventricular hypothalamic nuclei and in white adipose tissue. CHRONOBIOL INT 2015;32 (2):211-224 [PubMed]
van den Heuvel JK, Eggels L, van Rozen AJ, Fliers E, Kalsbeek A, Adan RAH, la Fleur SE, Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets. FRONT BEHAV NEUROSCI 2015;9:358 [PubMed]
van den Heuvel JK, Furman K, Gumbs MCR, Eggels L, Opland DM, Land BB, Kolk SM, S Narayanan N, Fliers E, Kalsbeek A, DiLeone RJ, la Fleur SE, Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. BIOL PSYCHIAT 2015;77 (7):633-641 [PubMed]
van Santen HM, Schouten-Meeteren AY, Serlie M, Meijneke RWH, van Trotsenburg AS, Verberne H, Holleman F, Fliers E, Effects of T3 treatment on brown adipose tissue and energy expenditure in a patient with craniopharyngioma and hypothalamic obesity. J PEDIATR ENDOCR MET 2015;28 (1-2):53-57 [PubMed]
Veldhuis-Vlug A. Neuroendocrine regulation of human bone metabolism. S.l.: s.n.; 2015. 123p. ISBN 978-94-6295-390-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E; copromotor(s): Bisschop PH)
Veldhuis-Vlug AG, Oei L, Souverein PC, Tanck MWT, Rivadeneira F, Zillikens MC, Kamphuisen PW, Maitland-van der Zee AH, de Groot MCH, Hofman A, Uitterlinden AG, Fliers E, de Boer A, Bisschop PH, Association of polymorphisms in the beta-2 adrenergic receptor gene with fracture risk and bone mineral density. OSTEOPOROSIS INT 2015;26 (7):2019-2027 [PubMed]
Veldhuis-Vlug AG, Tanck MW, Limonard EJ, Endert E, Heijboer AC, Lips P, Fliers E, Bisschop PH, The effects of beta-2 adrenergic agonist and antagonist on human bone metabolism: a randomized controlled trial. BONE 2015;71:196-200 [PubMed]
Vissenberg R, Manders VD, Mastenbroek S, Fliers E, Afink GB, Ris-Stalpers C, Goddijn M, Bisschop PH, Pathophysiological aspects of thyroid hormone disorders/thyroid peroxidase autoantibodies and reproduction. HUM REPROD UPDATE 2015;21 (3):378-387 [PubMed]
Vissenberg R, van Dijk MM, Fliers E, van der Post JAM, van Wely M, Bloemenkamp KWM, Hoek A, Kuchenbecker WK, Verhoeve HR, Scheepers HCJ, Rombout-de Weerd S, Koks C, Zwart JJ, Broekmans F, Verpoest W, Christiansen O, Post M, Papatsonis DNM, Verberg MFG, Sikkema J, Mol BW, Bisschop PH, Goddijn M, Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study). CONTEMP CLIN TRIALS 2015;44:134-138 [PubMed]
Borgers AJ, Koopman KE, Bisschop PH, Serlie MJ, Swaab DF, Fliers E, la Fleur SE, Alkemade A, Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects. FRONT NEUROSCI-SWITZ 2014;8:106 [PubMed]
Bruinstroop E, Fliers E, Kalsbeek A, Hypothalamic control of hepatic lipid metabolism via the autonomic nervous system. BEST PRACT RES CL EN 2014;28 (5):673-684 [PubMed]
de Vries EM, Eggels L, van Beeren HC, Ackermans MT, Kalsbeek A, Fliers E, Boelen A, Fasting-induced changes in hepatic thyroid hormone metabolism in male rats are independent of autonomic nervous input to the liver. ENDOCRINOLOGY 2014;155 (12):5033-5041 [PubMed]
de Vries EM, Kwakkel J, Eggels L, Kalsbeek A, Barrett P, Fliers E, Boelen A, NF kappa B Signaling Is Essential for the Lipopolysaccharide-Induced Increase of Type 2 Deiodinase in Tanycytes. ENDOCRINOLOGY 2014;155 (5):2000-2008 [PubMed]
de Weijer BA, van de Giessen E, Janssen I, Berends FJ, van de Laar A, Ackermans MT, Fliers E, la Fleur SE, Booij J, Serlie MJ, Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity. DIABETOLOGIA 2014;57 (5):1078-1080 [PubMed]
Elbers LPB, van Zaane B, Gerdes VEA, Coutinho JM, Bisschop PH, Fliers E, Venous thromboembolism in overt hyperthyroidism - a direct association with clinical implications?. NETH J MED 2014;72 (4):242-244 [PubMed]
Eskes SA. Clinical studies on thyroid diseases. s.l.: s.n.; 2014. 139p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E; copromotor(s): Wiersinga WM)
Eskes SA, Endert E, Fliers E, Birnie E, Hollenbach B, Schomburg L, Köhrle J, Wiersinga WM, Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies. CLIN ENDOCRINOL 2014;80 (3):444-451 [PubMed]
Fliers E, Boelen A, van Trotsenburg ASP. Central regulation of the hypothalamo-pituitary-thyroid (HPT) axis: focus on clinical aspects in: Fliers E, Korbonits M, Romijn JA, editors. Handbook of Clinical Neurology Vol.124. Toronto: Elsevier; 2014. Chapter 9, p. 127-138
Fliers E, Boelen A, van Trotsenburg ASP, Central regulation of the hypothalamo-pituitary-thyroid (HPT) axis: focus on clinical aspects. HANDB CLIN NEUROL 2014;124:127-138 [PubMed]
Fliers E, Kalsbeek A, Preface. BEST PRACT RES CL EN 2014;28 (5):633-634 [PubMed]
Fliers E, Kalsbeek A, Boelen A, Beyond the fixed setpoint of the hypothalamus-pituitary-thyroid axis. EUR J ENDOCRINOL 2014;171 (5):R197-R208 [PubMed]
Fliers E, Korbonits M, Romijn JA, editors, Handbook of Clinical Neurology Vol.124. Toronto: Elsevier; 2014. -p.
Fliers E, Korbonits M, Romijn JA, Preface. HANDB CLIN NEUROL 2014;124:ix [PubMed]
Girault EM, Guigas B, Alkemade A, Foppen E, Ackermans MT, la Fleur SE, Fliers E, Kalsbeek A, Chronic treatment with olanzapine increases adiposity by changing fuel substrate and causes desensitization of the acute metabolic side effects. N-S ARCH PHARMACOL 2014;387 (2):185-195 [PubMed]
Kalsbeek A, Bruinstroop E, Yi CX, Klieverik L, Liu J, Fliers E, Hormonal control of metabolism by the hypothalamus-autonomic nervous system-liver axis. FRONT HORM RES 2014;42:1-28 [PubMed]
Kalsbeek A, La Fleur S, Fliers E, Circadian control of glucose metabolism. MOL METAB 2014;3 (4):372-383 [PubMed]
Koopman KE, Caan MWA, Nederveen AJ, Pels A, Ackermans MT, Fliers E, la Fleur SE, Serlie MJ, Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial. HEPATOLOGY 2014;60 (2):545-553 [PubMed]
Koopman KEM. Central serotonin and dopamine transporters in overeating, obesity and insulin resistance. Amsterdam: s.n.; 2014. 176p. ISBN 978-90-9028511-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Booij J; copromotor(s): La Fleur SE, Serlie MJM)
Kwakkel J, Surovtseva OV, de Vries EM, Stap J, Fliers E, Boelen A, A Novel Role for the Thyroid Hormone-Activating Enzyme Type 2 Deiodinase in the Inflammatory Response of Macrophages. ENDOCRINOLOGY 2014;155 (7):2725-2734 [PubMed]
La Fleur SE, Fliers E, Kalsbeek A. Neuroscience of glucose homeostasis in: Zochodne DW, Malik RA, editors. Handbook of Clinical Neurology, Vol. 126 (3rd series). Toronto: Elsevier; 2014. -, p. 341-354
La Fleur SE, Fliers E, Kalsbeek A, Neuroscience of glucose homeostasis. HANDB CLIN NEUROL 2014;126:341-351 [PubMed]
Lammers NM, Sondermeijer BM, Twickler TBM, de Bie RM, Ackermans MT, Fliers E, Schuurman PR, la Fleur SE, Serlie MJ, Subthalamic nucleus stimulation does not influence basal glucose metabolism or insulin sensitivity in patients with Parkinson's disease. FRONT NEUROSCI-SWITZ 2014;8:95 [PubMed]
Martínez de Morentin PB, González-García I, Martins L, Lage R, Fernández-Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena-Sempere M, López M, Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. CELL METAB 2014;20 (1):41-53 [PubMed]
Roelfsema F, Pijl H, Kok P, Endert E, Fliers E, Biermasz NR, Pereira AM, Veldhuis JD, Thyrotropin Secretion in Healthy Subjects Is Robust and Independent of Age and Gender, and Only Weakly Dependent on Body Mass Index. J CLIN ENDOCR METAB 2014;99 (2):570-578 [PubMed]
Stenvers DJ, Schouten LJ, Jurgens J, Endert E, Kalsbeek A, Fliers E, Bisschop PH, Breakfast replacement with a low-glycaemic response liquid formula in patients with type 2 diabetes: a randomised clinical trial. BRIT J NUTR 2014;112 (4):504-512 [PubMed]
van den Heuvel JK. Neural pathways controlling homeostatic and hedonic feeding in rats on free-choice diets. S.l.: s.n.; 2014. 168p. ISBN 9789461824660 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kalsbeek A, Fliers E; copromotor(s): La Fleur SE)
van den Heuvel JK, Eggels L, Fliers E, Kalsbeek A, Adan RAH, la Fleur SE, Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet. PLOS ONE 2014;9 (1):e87729 [PubMed]
van den Heuvel JK, Eggels L, van Rozen AJ, Luijendijk MCM, Fliers E, Kalsbeek A, Adan RAH, La Fleur SE, Neuropeptide Y and leptin sensitivity is dependent on diet composition. J NEUROENDOCRINOL 2014;26 (6):377-385 [PubMed]
van Varsseveld NC, Bisschop PHLT, Biermasz NR, Pereira AM, Fliers E, Drent ML, A long-term follow-up study of eighteen patients with thyrotrophin-secreting pituitary adenomas. CLIN ENDOCRINOL 2014;80 (3):395-402 [PubMed]
van Zeijl CJJ, Surovtseva OV, Kwakkel J, van Beeren HC, Duncan Bassett JH, Williams GR, Wiersinga WM, Fliers E, Boelen A, Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness. AM J PHYSIOL-ENDOC M 2014;307 (6):E527-E537 [PubMed]
Bisschop PH, Dekker MJHJ, Osterthun W, Kwakkel J, Anink JJ, Boelen A, Unmehopa UA, Koper JW, Lamberts SWJ, Stewart PM, Swaab DF, Fliers E, Expression of 11β-hydroxysteroid dehydrogenase type 1 in the human hypothalamus. J NEUROENDOCRINOL 2013;25 (5):425-432 [PubMed]
Borgers AJ, Alkemade A, van de Giessen EM, Drent ML, Booij J, Bisschop PH, Fliers E, Imaging of serotonin transporters with [I-123]FP-CIT SPECT in the human hypothalamus. EJNMMI RES 2013;3 (1):UNSP 34 [PubMed]
Borgers AJF. Hypothalamic functions in patients with pituitary insufficiency. s.l.: s.n.; 2013. 167p. ISBN 9789082058505 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E; copromotor(s): Alkemade JM, Bisschop PHLT)
Borgers AJ, Fliers E, Siljee JE, Swaab DF, van Someren EJW, Bisschop PH, Alkemade A, Arginine vasopressin immunoreactivity is decreased in the hypothalamic suprachiasmatic nucleus of subjects with suprasellar tumors. BRAIN PATHOL 2013;23 (4):440-444 [PubMed]
Bruinstroop E. Neural control of hepatic lipid metabolism. A (patho)physiological perspective. s.l.: s.n.; 2013. 151p. ISBN 9789461823199 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kalsbeek A, Fliers E; copromotor(s): )
Bruinstroop E, la Fleur SE, Ackermans MT, Foppen E, Wortel J, Kooijman S, Berbée JFP, Rensen PCN, Fliers E, Kalsbeek A, The autonomic nervous system regulates postprandial hepatic lipid metabolism. AM J PHYSIOL-ENDOC M 2013;304 (10):E1089-E1096 [PubMed]
de Koning PP, Figee M, Endert E, Storosum JG, Fliers E, Denys D, Deep brain stimulation for obsessive-compulsive disorder is associated with cortisol changes. PSYCHONEUROENDOCRINO 2013;38 (8):1455-1459 [PubMed]
de Weijer BA, Aarts E, Janssen IMC, Berends FJ, van de Laar A, Kaasjager K, Ackermans MT, Fliers E, Serlie MJ, Hepatic and peripheral insulin sensitivity do not improve 2 weeks after bariatric surgery. OBESITY 2013;21 (6):1143-1147 [PubMed]
Diepenbroek C, Serlie MJ, Fliers E, Kalsbeek A, la Fleur SE, Brain areas and pathways in the regulation of glucose metabolism. BIOFACTORS 2013;39 (5):505-513 [PubMed]
Diepenbroek C, van der Plasse G, Eggels L, Rijnsburger M, Feenstra MGP, Kalsbeek A, Denys D, Fliers E, Serlie MJ, la Fleur SE, Alterations in blood glucose and plasma glucagon concentrations during deep brain stimulation in the shell region of the nucleus accumbens in rats. FRONT NEUROSCI-SWITZ 2013;7:226 [PubMed]
Fliers E. Endocriene dwarsverbanden: de Endocrine Society, de Nederlandse Vereniging voor Endocrinologie en de European Society of Endocrinology in: Elte JW, Geelhoed N, de Heide L, de Herder W, Pijl H, editors. Canon van de Endocrinologie. S.l.: NVE; 2013., p. 116-117
Girault EM. The role of hypothalamic pathways in the metabolic side effects of Olanzapine. s.l.: s.n.; 2013. 156p. ISBN 9789088917352 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kalsbeek A, Fliers E; copromotor(s): La Fleur SE)
Girault EM, Foppen E, Ackermans MT, Fliers E, Kalsbeek A, Central administration of an orexin receptor 1 antagonist prevents the stimulatory effect of Olanzapine on endogenous glucose production. BRAIN RES 2013;1527:238-245 [PubMed]
Girault EM, Toonen PW, Eggels L, Foppen E, Ackermans MT, la Fleur SE, Fliers E, Kalsbeek A, Olanzapine-induced changes in glucose metabolism are independent of the melanin-concentrating hormone system. PSYCHONEUROENDOCRINO 2013;38 (11):2640-2646 [PubMed]
Grandiek M, van Campen JPMC, Fliers E, An unusual cause of hyponatremia in an older adult. J AM GERIATR SOC 2013;61 (4):658-659 [PubMed]
Kalsbeek A, Fliers E, Daily regulation of hormone profiles. HANDB EXP PHARMACOL 2013;217 (217):185-226 [PubMed]
Koopman KE, Booij J, Fliers E, Serlie MJ, la Fleur SE, Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region. MOL METAB 2013;2 (4):417-422 [PubMed]
Liu J. The role of estrogen in hypothalamic regulation of hypothalamus-pituitary-adrenal axis activity, energy homeostasis and bone metabolism. s.l.: s.n.; 2013. 133p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Kalsbeek A; copromotor(s): Bisschop PHLT, Zhou JN)
Liu J, Bisschop PH, Eggels L, Foppen E, Ackermans MT, Zhou JN, Fliers E, Kalsbeek A, Intrahypothalamic estradiol regulates glucose metabolism via the sympathetic nervous system in female rats. DIABETES 2013;62 (2):435-443 [PubMed]
Meijer JAA, Bakker LEH, Valk GD, de Herder WW, de Wilt JHW, Netea-Maier RT, Schaper N, Fliers E, Lips P, Plukker JT, Links TP, Smit JA, Radioactive iodine in the treatment of medullary thyroid carcinoma: a controlled multicenter study. EUR J ENDOCRINOL 2013;168 (5):779-786 [PubMed]
Siljee JE, Unmehopa UA, Kalsbeek A, Swaab DF, Fliers E, Alkemade A, Melanocortin 4 receptor distribution in the human hypothalamus. EUR J ENDOCRINOL 2013;168 (3):361-369 [PubMed]
van Bunderen CC, van Varsseveld NC, Baayen JC, van Furth WR, Aliaga ES, Hazewinkel MJ, Majoie CBLM, Freling NJM, Lips P, Fliers E, Bisschop PH, Drent ML, Predictors of endoscopic transsphenoidal surgery outcome in acromegaly: patient and tumor characteristics evaluated by magnetic resonance imaging. PITUITARY 2013;16 (2):158-167 [PubMed]
Varewijck AJ, Boelen A, Lamberts SWJ, Fliers E, Hofland LJ, Wiersinga WM, Janssen JAMJL, Circulating IgGs May Modulate IGF-I Receptor Stimulating Activity in a Subset of Patients With Graves' Ophthalmopathy. J CLIN ENDOCR METAB 2013;98 (2):769-776 [PubMed]
Veldhuis-Vlug AG, Fliers E, Bisschop PH, Bone as a regulator of glucose metabolism. NETH J MED 2013;71 (8):396-400 [PubMed]
Alkemade A, Unmehopa UA, Hessel EVS, Swaab DF, Kalsbeek A, Fliers E, Suppressor of cytokine signaling 3 in the human hypothalamus. PEPTIDES 2012;35 (1):139-142 [PubMed]
Alkemade A, Yi CX, Pei L, Harakalova M, Swaab DF, la Fleur SE, Fliers E, Kalsbeek A, AgRP and NPY Expression in the Human Hypothalamic Infundibular Nucleus Correlate with Body Mass Index, Whereas Changes in alpha MSH Are Related to Type 2 Diabetes. J CLIN ENDOCR METAB 2012;97 (6):E925-E933 [PubMed]
Boelen A, Kwakkel J, Fliers E, Thyroid hormone receptors in health and disease. MINERVA ENDOCRINOL 2012;37 (4):291-303 [PubMed]
Boelen A, van Beeren M, Vos X, Surovtseva O, Belegri E, Saaltink DJ, Vreugdenhil E, Kalsbeek A, Kwakkel J, Fliers E, Leptin Administration Restores the Fasting-Induced Increase of Hepatic Type 3 Deiodinase Expression in Mice. THYROID 2012;22 (2):192-199 [PubMed]
Borgers AJ, Alkemade A, Venema HW, Fliers E, Bisschop PH, A history of cranial radiotherapy is associated with a higher visceral to subcutaneous fat ratio in men with pituitary insufficiency. EUR J ENDOCRINOL 2012;166 (4):619-624 [PubMed]
Bruinstroop E, Pei L, Ackermans MT, Foppen E, Borgers AJ, Kwakkel J, Alkemade A, Fliers E, Kalsbeek A, Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System. DIABETES 2012;61 (5):1043-1050 [PubMed]
Eskes SA, Endert E, Fliers E, Geskus RB, Dullaart RPF, Links TP, Wiersinga WM, Treatment of Amiodarone-Induced Thyrotoxicosis Type 2: A Randomized Clinical Trial. J CLIN ENDOCR METAB 2012;97 (2):499-506 [PubMed]
Fliers E, van Furth WR, Bisschop PH, Cure of a thyrotrophin (TSH)-secreting pituitary adenoma by medical therapy. CLIN ENDOCRINOL 2012;77 (5):788-790 [PubMed]
Friesema ECH, Visser TJ, Borgers AJ, Kalsbeek A, Swaab DF, Fliers E, Alkemade A, Thyroid hormone transporters and deiodinases in the developing human hypothalamus. EUR J ENDOCRINOL 2012;167 (3):379-386 [PubMed]
Girault EM, Alkemade A, Foppen E, Ackermans MT, Fliers E, Kalsbeek A, Acute Peripheral but Not Central Administration of Olanzapine Induces Hyperglycemia Associated with Hepatic and Extra-Hepatic Insulin Resistance. PLOS ONE 2012;7 (8):e43244 [PubMed]
Girault EM, Yi CX, Fliers E, Kalsbeek A, Orexins, feeding, and energy balance. PROG BRAIN RES 2012;198:47-64 [PubMed]
Kalsbeek A, Fliers E. Hypothalamus in: Pfaff DW, editor. Neuroscience in the 21st Century. Berlin: Springer; 2012., p. 1365-1405
Kalsbeek A, Liu J, Lei J, Timmermans L, Foppen E, Cailotto C, Fliers E, Differential Involvement of the Suprachiasmatic Nucleus in Lipopolysaccharide-Induced Plasma Glucose and Corticosterone Responses. CHRONOBIOL INT 2012;29 (7):835-849 [PubMed]
Kalsbeek A, van der Spek R, Lei J, Endert E, Buijs RM, Fliers E, Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis. MOL CELL ENDOCRINOL 2012;349 (1):20-29 [PubMed]
Koopman KE, la Fleur SE, Fliers E, Serlie MJ, Booij J, Assessing the Optimal Time Point for the Measurement of Extrastriatal Serotonin Transporter Binding with I-123-FP-CIT SPECT in Healthy, Male Subjects. J NUCL MED 2012;53 (7):1087-1090 [PubMed]
Kootte RS, Stuijver DJF, Dekkers OM, van Zaane B, Fliers E, Cannegieter SC, Gerdes VEA, The incidence of venous thromboembolism in patients with overt hyperthyroidism A retrospective multicentre cohort study. THROMB HAEMOSTASIS 2012;107 (3):417-422 [PubMed]
Limonard EJ, Bisschop PH, Fliers E, Nieveen van Dijkum EJ, Thyroid Function after Subtotal Thyroidectomy in Patients with Graves' Hyperthyroidism. SCI WORLD J 2012;2012:1 548796-5 [PubMed]
Liu J, Bisschop PH, Eggels L, Foppen E, Fliers E, Zhou JN, Kalsbeek A, Intrahypothalamic Estradiol Modulates Hypothalamus-Pituitary-Adrenal-Axis Activity in Female Rats. ENDOCRINOLOGY 2012;153 (7):3337-3344 [PubMed]
Louwerens M, Appelhof BC, Verloop H, Medici M, Peeters RP, Visser TJ, Boelen A, Fliers E, Smit JWA, Dekkers OM, Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism. EUR J ENDOCRINOL 2012;167 (6):809-815 [PubMed]
Romeijn N, Borgers AJ, Fliers E, Alkemade A, Bisschop PH, van Someren EJW, Medical History of Optic Chiasm Compression in Patients With Pituitary Insufficiency Affects Skin Temperature and Its Relation to Sleep. CHRONOBIOL INT 2012;29 (8):1098-1108 [PubMed]
Sondermeijer BM, Klein Twennaar CF, Kastelein JJP, Franssen EJF, Hutten BA, Dallinga-Thie GM, Stroes ESG, Fliers E, Twickler MTB, Serlie MJ, Infusion of a Lipid Emulsion in Healthy Men Decreases the Serotonergic Response. NEUROENDOCRINOLOGY 2012;95 (4):325-331 [PubMed]
Stenvers DJ, Jonkers CF, Fliers E, Bisschop PHLT, Kalsbeek A, Nutrition and the circadian timing system. PROG BRAIN RES 2012;199:359-376 [PubMed]
van Beeren HC, Kwakkel J, Ackermans MT, Wiersinga WM, Fliers E, Boelen A, Action of Specific Thyroid Hormone Receptor alpha(1) and beta(1) Antagonists in the Central and Peripheral Regulation of Thyroid Hormone Metabolism in the Rat. THYROID 2012;22 (12):1275-1282 [PubMed]
van der Spek R, Kreier F, Fliers E, Kalsbeek A, Circadian rhythms in white adipose tissue. PROG BRAIN RES 2012;199:183-201 [PubMed]
van Zeijl CJJ, van Koppen CJ, Surovtseva OV, de Gooyer ME, Plate R, Conti P, Karstens WJ, Timmers M, Saeed P, Wiersinga WM, Miltenburg AMM, Fliers E, Boelen A, Complete Inhibition of rhTSH-, Graves' Disease IgG-, and M22-Induced cAMP Production in Differentiated Orbital Fibroblasts by a Low-Molecular-Weight TSHR Antagonist. J CLIN ENDOCR METAB 2012;97 (5):E781-E785 [PubMed]
Veldhuis-Vlug AG, El Mahdiui M, Endert E, Heijboer AC, Fliers E, Bisschop PH, Bone Resorption Is Increased in Pheochromocytoma Patients and Normalizes following Adrenalectomy. J CLIN ENDOCR METAB 2012;97 (11):E2093-E2097 [PubMed]
Vissenberg R, Goddijn M, Mol BW, van der Post JA, Fliers E, Bisschop PH, Schildklierdisfunctie bij zwangeren: klinische dilemma's. NED TIJDSCHR GENEESKD 2012;156 (49):A5163 [PubMed]
Vissenberg R, van den Boogaard E, van Wely M, van der Post JA, Fliers E, Bisschop PH, Goddijn M, Treatment of thyroid disorders before conception and in early pregnancy: a systematic review. HUM REPROD UPDATE 2012;18 (4):360-373 [PubMed]
Wentholt IME, Bras J, Kroon FHM, Nieveen van Dijkum EJM, Fliers E, Vitamin D, or wait and see?. NETH J MED 2012;70 (6):292-293 [PubMed]
Yi CX, Foppen E, Abplanalp W, Gao Y, Alkemade A, la Fleur SE, Serlie MJ, Fliers E, Buijs RM, Tschöp MH, Kalsbeek A, Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity. DIABETES 2012;61 (2):339-345 [PubMed]
Alkemade A, Friesema ECH, Kalsbeek A, Swaab DF, Visser TJ, Fliers E, Expression of Thyroid Hormone Transporters in the Human Hypothalamus. J CLIN ENDOCR METAB 2011;96 (6):E967-E971 [PubMed]
Boelen A, Kwakkel J, Fliers E, Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. ENDOCR REV 2011;32 (5):670-693 [PubMed]
Borgers AJ, Romeijn N, van Someren E, Fliers E, Alkemade A, Bisschop PH, Compression of the optic chiasm is associated with permanent shorter sleep duration in patients with pituitary insufficiency. CLIN ENDOCRINOL 2011;75 (3):347-353 [PubMed]
de Fost M, van Trotsenburg ASP, van Santen HM, Endert E, van den Elzen C, Kamsteeg EJ, Swaab DF, Fliers E, Familial neurohypophyseal diabetes insipidus due to a novel mutation in the arginine vasopressin-neurophysin II gene. EUR J ENDOCRINOL 2011;165 (1):161-165 [PubMed]
de Weijer BA, van de Giessen E, van Amelsvoort TA, Boot E, Braak B, Janssen IM, van de Laar A, Fliers E, Serlie MJ, Booij J, Lower striatal dopamine D-2/3 receptor availability in obese compared with non-obese subjects. EJNMMI RES 2011;1 (1):37 [PubMed]
Kalsbeek A, Chun-Xia Y, La Fleur S, Fliers E, De rol van de biologische klok en het autonome zenuwstelsel bij wakker worden. NEUROPRAXIS 2011;15:159-171
Kalsbeek A, Scheer FA, Perreau-Lenz S, la Fleur SE, Yi CX, Fliers E, Buijs RM, Circadian disruption and SCN control of energy metabolism. FEBS LETT 2011;585 (10):1412-1426 [PubMed]
Kalsbeek A, Yi CX, Cailotto C, la Fleur SE, Fliers E, Buijs RM, Mammalian clock output mechanisms. ESSAYS BIOCHEM 2011;49 (1):137-151 [PubMed]
Klieverik LP, Kalsbeek A, Ackermans MT, Sauerwein HP, Wiersinga WM, Fliers E, Energy Homeostasis and Body Weight before and after Cessation of Block and Replacement Therapy in Euthyroid Patients with Graves' Disease. INT J ENDOCRINOL 2011;2011:715370 [PubMed]
Kwakkel J, Fliers E, Boelen A, Illness-induced changes in thyroid hormone metabolism: focus on the tissue level. NETH J MED 2011;69 (5):224-228 [PubMed]
Serlie MJ, La Fleur SE, Fliers E, Obesity: is evolution to blame?. NETH J MED 2011;69 (4):156-158 [PubMed]
Stuijver DJF, van Zaane B, Feelders RA, Debeij J, Cannegieter SC, Hermus AR, van den Berg G, Pereira AM, de Herder WW, Wagenmakers MAEM, Kerstens MN, Zelissen PMJ, Fliers E, Schaper N, Drent ML, Dekkers OM, Gerdes VEA, Incidence of venous thromboembolism in patients with Cushing's syndrome: a multicenter cohort study. J CLIN ENDOCR METAB 2011;96 (11):3525-3532 [PubMed]
van Zeijl CJJ. Nonclassical ligands for the thyrotropin receptor. Functional studies on thyrostimulin and Graves' disease immunoglobulins. s.l.: s.n.; 2011. 189p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Wiersinga WM; copromotor(s): Boelen A, van Koppen CJ)
van Zeijl CJJ, Fliers E, van Koppen CJ, Surovtseva OV, de Gooyer ME, Mourits MP, Wiersinga WM, Miltenburg AMM, Boelen A, Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways. THYROID 2011;21 (2):169-176 [PubMed]
van Zeijl CJJ, Surovtseva OV, Wiersinga WM, Fliers E, Boelen A, Acute Inflammation Increases Pituitary and Hypothalamic Glycoprotein Hormone Subunit B5 mRNA Expression in Association with Decreased Thyrotrophin Receptor mRNA Expression in Mice. J NEUROENDOCRINOL 2011;23 (4):310-319 [PubMed]
Ackermans MT, Klieverik LP, Ringeling P, Endert E, Kalsbeek A, Fliers E, An online Solid-Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxine. J ENDOCRINOL 2010;206 (3):327-334 [PubMed]
Benhadi N, Fliers E, Visser TJ, Reitsma JB, Wiersinga WM, Pilot study on the assessment of the setpoint of the hypothalamus-pituitary-thyroid axis in healthy volunteers. EUR J ENDOCRINOL 2010;162 (2):323-329 [PubMed]
Eskes SA, Endert E, Fliers E, Wiersinga WM, Prevalence of Growth Hormone Deficiency in Hashimoto's Thyroiditis. J CLIN ENDOCR METAB 2010;95 (5):2266-2270 [PubMed]
Fliers E, Bisschop PHLT, Serlie MJM. Endocrinologische Aandoeningen; De bijnier in: Willems JHBM, Croon NHTH, Koten JW, editors. Handboek Arbeid en Belastbaarheid. Bilthoven: Bohn Stafleu Van Loghem; 2002. Katern, p. 24-33
Fliers E, Bisschop PHLT, Serlie MJM. Endocrinologische Aandoeningen; De hypofyse in: Willems JHBM, Croon NHTH, Koten JW, editors. Handboek Arbeid en Belastbaarheid. Bilthoven: Bohn Stafleu Van Loghem; 2002. Katern, p. 3-12
Fliers E, Bisschop PHLT, Serlie MJM. Endocrinologische Aandoeningen; De Schildklier in: Willems JHBM, Croon NHTH, Koten JW, editors. Handboek Arbeid en Belastbaarheid. Bilthoven: Bohn Stafleu Van Loghem; 2002. Katern, p. 12-21
Fliers E, Bisschop PHLT, Serlie MJM. Endocrinologische Aandoeningen Inleiding in: Willems JHBM, Croon NHTH, Koten JW, editors. Handboek Arbeid en Belastbaarheid. Bilthoven: Bohn Stafleu Van Loghem; 2002. Katern, p. 3-3
Fliers E, Boelen A, Type 2 Deiodinase and Brown Fat: The Heat Is On--or Off. ENDOCRINOLOGY 2010;151 (9):4087-4089 [PubMed]
Fliers E, Klieverik LP, Kalsbeek A, Novel neural pathways for metabolic effects of thyroid hormone. TRENDS ENDOCRIN MET 2010;21 (4):230-236 [PubMed]
Kalsbeek A, Bruinstroop E, Yi CX, Klieverik LP, La Fleur SE, Fliers E, Hypothalamic control of energy metabolism via the autonomic nervous system. ANN NY ACAD SCI 2010;1212 (1):114-129 [PubMed]
Kalsbeek A, Fliers E, Hofman MA, Swaab DF, Buijs RM, Vasopressin and the Output of the Hypothalamic Biological Clock. J NEUROENDOCRINOL 2010;22 (5):362-372 [PubMed]
Kalsbeek A, Yi CX, la Fleur SE, Buijs RM, Fliers E, SUPRACHIASMATIC NUCLEUS AND AUTONOMIC NERVOUS SYSTEM INFLUENCES ON AWAKENING FROM SLEEP. INT REV NEUROBIOL 2010;93:91-107 [PubMed]
Kalsbeek A, Yi CX, la Fleur SE, Fliers E, The hypothalamic clock and its control of glucose homeostasis. TRENDS ENDOCRIN MET 2010;21 (7):402-410 [PubMed]
Kwakkel GJ. Understanding the non-thyroidal illness syndrome frrom in vivo and iin vitro studies. s.l.: s.n.; 2010. 189p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Wiersinga WM, Fliers E; copromotor(s): Boelen A)
Kwakkel J, Chassande O, van Beeren HC, Fliers E, Wiersinga WM, Boelen A, Thyroid Hormone Receptor alpha Modulates Lipopolysaccharide-Induced Changes in Peripheral Thyroid Hormone Metabolism. ENDOCRINOLOGY 2010;151 (4):1959-1969 [PubMed]
Roelfsema F, Pereira AM, Adriaanse R, Endert E, Fliers E, Romijn JA, Veldhuis JD, Thyrotropin Secretion in Mild and Severe Primary Hypothyroidism Is Distinguished by Amplified Burst Mass and Basal Secretion with Increased Spikiness and Approximate Entropy. J CLIN ENDOCR METAB 2010;95 (2):928-934 [PubMed]
Soeters MR, Huidekoper HH, Duran M, Ackermans MT, Endert E, Fliers E, Wijburg FA, Wanders RJ, Sauerwein HP, Serlie MJ, Extended metabolic evaluation of suspected symptomatic hypoglycemia: the prolonged fast and beyond. METABOLISM 2010;59 (11):1543-1550 [PubMed]
van Zaane B, Squizzato A, Huijgen R, van Zanten AP, Fliers E, Cannegieter SC, Büller HR, Gerdes VEA, Brandjes DPM, Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study. BLOOD 2010;115 (22):4344-4349 [PubMed]
van Zeijl CJJ, Fliers E, van Koppen CJ, Surovtseva OV, de Gooyer ME, Mourits MP, Wiersinga WM, Miltenburg AMM, Boelen A, Effects of Thyrotropin and Thyrotropin-Receptor-Stimulating Graves' Disease Immunoglobulin G on Cyclic Adenosine Monophosphate and Hyaluronan Production in Nondifferentiated Orbital Fibroblasts of Graves' Ophthalmopathy Patients. THYROID 2010;20 (5):535-244 [PubMed]
van Zeijl CJJ, Surovtseva OV, Wiersinga WM, Boelen A, Fliers E, Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice. MOL CELL ENDOCRINOL 2010;321 (2):231-238 [PubMed]
Yi CX. Hypothalamic neural networks in control of glucose homeostasis. s.l.: s.n.; 2010. 240p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Buijs RM; copromotor(s): Kalsbeek A, Serlie MJM)
Yi CX, la Fleur SE, Fliers E, Kalsbeek A, The role of the autonomic nervous liver innervation in the control of energy metabolism. BBA-MOL BASIS DIS 2010;1802 (4):416-431 [PubMed]
Yi CX, Sun N, Ackermans MT, Alkemade A, Foppen E, Shi J, Serlie MJ, Buijs RM, Fliers E, Kalsbeek A, Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Glucose Production via the Hepatic Sympathetic Innervation in Rats. DIABETES 2010;59 (7):1591-1600 [PubMed]
Bisschop PH, Corssmit EPM, Baas SJ, Serlie MJ, Endert E, Wiersinga WM, Fliers E, Evaluation of Endocrine Tests. C: glucagon and clonidine test in phaeochromocytoma. NETH J MED 2009;67 (3):91-95 [PubMed]
Boelen A, Kwakkel J, Chassande O, Fliers E, Thyroid Hormone Receptor beta Mediates Acute Illness-Induced Alterations in Central Thyroid Hormone Metabolism. J NEUROENDOCRINOL 2009;21 (5):465-472 [PubMed]
Boelen A, Kwakkel J, Wieland CW, St Germain DL, Fliers E, Hernandez A, Impaired bacterial clearance in type 3 deiodinase deficient mice infected with Streptococcus pneumoniae. ENDOCRINOLOGY 2009;150 (4):1984-1990 [PubMed]
Boelen A, Mikita J, Boiziau C, Chassande O, Fliers E, Petry KG, Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis. THYROID 2009;19 (12):1401-1406 [PubMed]
Eskes SA, Tomasoa NB, Endert E, Geskus RB, Fliers E, Wiersinga WM, Establishment of reference values for endocrine tests. Part VII: Growth hormone deficiency. NETH J MED 2009;67 (4):127-133 [PubMed]
Faneyte IF, Sanson RE, van Eeden S, Fliers E, Gouma DJ, Nieveen van Dijkum EJM, Een patiënte met een recidief van hyperparathyreoïdie en een zwelling in de hals. NED TIJDSCHR GENEESKD 2009;153 (38):B249 [PubMed]
Fliers E. Hypothalamus-Pituitary-Thyroid Axis in: Binder MD, Hirokawa N, Windhorst U, editors. Encyclopedia of Neuroscience. S.l.: Springer; 2009., p. 1900-1903
Heemstra KA, Hoftijzer HC, van der Deure WM, Peeters RP, Fliers E, Appelhof BC, Wiersinga WM, Corssmit EPM, Visser TJ, Smit JWA, Thr92Ala polymorphism in the type 2 deiodinase is not associated with T4 dose in athyroid patients or patients with Hashimoto thyroiditis. CLIN ENDOCRINOL 2009;71 (2):279-283 [PubMed]
Heemstra KA, Soeters MR, Fliers E, Serlie MJ, Burggraaf J, van Doorn MB, van der Klaauw AA, Romijn JA, Smit JW, Corssmit EP, Visser TJ, Type 2 Iodothyronine Deiodinase in Skeletal Muscle: Effects of Hypothyroidism and Fasting. J CLIN ENDOCR METAB 2009;94 (6):2144-2150 [PubMed]
Klieverik LP. Thyroid hormone, metabolism and the brain. s.l.: s.n.; 2009. 139p. ISBN 9789090245416 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Sauerwein HP; copromotor(s): Kalsbeek A, Ackermans MT)
Klieverik LP, Coomans CP, Endert E, Sauerwein HP, Havekes LM, Voshol PJ, Rensen PCN, Romijn JA, Kalsbeek A, Fliers E, Thyroid Hormone Effects on Whole-Body Energy Homeostasis and Tissue-Specific Fatty Acid Uptake in Vivo. ENDOCRINOLOGY 2009;150 (12):5639-5648 [PubMed]
Klieverik LP, Foppen E, Ackermans MT, Serlie MJ, Sauerwein HP, Scanlan TS, Grandy DK, Fliers E, Kalsbeek A, Central effects of thyronamines on glucose metabolism in rats. J ENDOCRINOL 2009;201 (3):377-386 [PubMed]
Klieverik LP, Janssen SF, van Riel A, Foppen E, Bisschop PH, Serlie MJ, Boelen A, Ackermans MT, Sauerwein HP, Fliers E, Kalsbeek A, Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. P NATL ACAD SCI USA 2009;106 (14):5966-5971 [PubMed]
Kwakkel J, van Beeren HC, Ackermans MT, Platvoet-ter Schiphorst MC, Fliers E, Wiersinga WM, Boelen A, Skeletal muscle deiodinase type 2 regulation during illness in mice. J ENDOCRINOL 2009;203 (2):263-270 [PubMed]
Mebis L, Debaveye Y, Ellger B, Derde S, Ververs EJ, Langouche L, Darras VM, Fliers E, Visser TJ, van den Berghe G, Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness. CRIT CARE 2009;13 (5):R147 [PubMed]
Roelfsema F, Pereira AM, Veldhuis JD, Adriaanse R, Endert E, Fliers E, Romijn JA, Thyrotropin Secretion Profiles Are Not Different in Men and Women. J CLIN ENDOCR METAB 2009;94 (10):3964-3967 [PubMed]
Soeters MR, Lammers NM, Dubbelhuis PF, Ackermans MT, Jonkers-Schuitema CF, Fliers E, Sauerwein HP, Aerts JM, Serlie MJ, Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism. AM J CLIN NUTR 2009;90 (5):1244-1251 [PubMed]
Soeters MR, Sauerwein HP, Duran M, Wanders RJ, Ackermans MT, Fliers E, Houten SM, Serlie MJ, Muscle acylcarnitines during short-term fasting in lean healthy men. CLIN SCI 2009;116 (7):585-592 [PubMed]
Soeters MR, Sauerwein HP, Faas L, Smeenge M, Duran M, Wanders RJ, Ruiter AF, Ackermans MT, Fliers E, Houten SM, Serlie MJ, Effects of insulin on ketogenesis following fasting in lean and obese men. OBESITY 2009;17 (7):1326-1331 [PubMed]
van Bon AC, Benhadi N, Endert E, Fliers E, Wiersinga WM, Evaluation of Endocrine Tests. D: the prolonged fasting test for insulinoma. NETH J MED 2009;67 (7):274-278 [PubMed]
van Zaane B, Nur E, Squizzato A, Dekkers OM, Twickler MTB, Fliers E, Gerdes VEA, Büller HR, Brandjes DPM, Hypercoagulable State in Cushing's Syndrome: A Systematic Review. J CLIN ENDOCR METAB 2009;94 (8):2743-2750 [PubMed]
Yi CX, Serlie MJ, Ackermans MT, Foppen E, Buijs RM, Sauerwein HP, Fliers E, Kalsbeek A, A Major Role for Perifornical Orexin Neurons in the Control of Glucose Metabolism in Rats. DIABETES 2009;58 (9):1998-2005 [PubMed]
Ackermans MT, Klieverik LP, Endert E, Sauerwein HP, Kalsbeek A, Fliers E, Plasma insulin concentrations during a hyperinsulinaemic clamp: what do we measure?. ANN CLIN BIOCHEM 2008;45 (Part 4):429-430 [PubMed]
Alkemade A, Visser TJ, Fliers E, Thyroid hormone signaling in the hypothalamus. CURR OPIN ENDOCRINOL 2008;15 (5):453-458 [PubMed]
Asherson P, Zhou K, Anney RJL, Franke B, Buitelaar J, Ebstein R, Gill M, Altink M, Arnold R, Boer F, Brookes K, Buschgens C, Butler L, Cambell D, Chen W, Christiansen H, Feldman L, Fleischman K, Fliers E, Howe-Forbes R, Goldfarb A, Heise A, Gabriëls I, Johansson L, Lubetzki I, Marco R, Medad S, Minderaa R, Mulas F, Müller U, Mulligan A, Neale B, Rijsdijk F, Rabin K, Rommelse N, Sethna V, Sorohan J, Uebel H, Psychogiou L, Weeks A, Barrett R, Xu X, Banaschewski T, Sonuga-Barke E, Eisenberg J, Manor I, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Faraone SV, A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16. MOL PSYCHIATR 2008;13 (5):514-521 [PubMed]
Boelen A, Boorsma J, Kwakkel J, Wieland CW, Renckens R, Visser TJ, Fliers E, Wiersinga WM, Type 3 Deiodinase Is Highly Expressed in Infiltrating Neutrophilic Granulocytes in Response to Acute Bacterial Infection. THYROID 2008;18 (10):1095-1103 [PubMed]
Boelen A, Wiersinga WM, Fliers E, Fasting-induced changes in the hypothalamus-pituitary-thyroid axis. THYROID 2008;18 (2):123-129 [PubMed]
Kalsbeek A, Foppen E, Schalij I, van Heijningen C, van der Vliet J, Fliers E, Buijs RM, Circadian control of the daily plasma glucose rhythm: an interplay of GABA and glutamate. PLOS ONE 2008;3 (9):e3194 [PubMed]
Klieverik LP, Sauerwein HP, Ackermans MT, Boelen A, Kalsbeek A, Fliers E, Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. AM J PHYSIOL-ENDOC M 2008;294 (3):E513-E520 [PubMed]
Michel MC, Fliers E, van Noorden CJF, Dipeptidyl peptidase IV inhibitors in diabetes: more than inhibition of glucagon-like peptide-1 metabolism?. N-S ARCH PHARMACOL 2008;377 (3):205-207 [PubMed]
Soeters MR, Sauerwein HP, Dubbelhuis PF, Groener JE, Ackermans MT, Fliers E, Aerts JM, Serlie MJ, Muscle adaptation to short-term fasting in healthy lean humans. J CLIN ENDOCR METAB 2008;93 (7):2900-2903 [PubMed]
van Bon AC, Krudop W, van Eeden S, Schreuder MCJ, Nieveen van Dijkum EJM, Fliers E, Wiersinga WM, Een pijnlijke hals door acute suppuratieve thyreoïditis veroorzaakt door Salmonella. NED TIJDSCHR GENEESKD 2008;152 (38):2084-2087 [PubMed]
van der Deure WM, Appelhof BC, Peeters RP, Wiersinga WM, Wekking EM, Huyser J, Schene AH, Tijssen JGP, Hoogendijk WJG, Visser TJ, Fliers E, Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients. CLIN ENDOCRINOL 2008;69 (5):804-811 [PubMed]
van Nimwegen LJM, Storosum JG, Blumer RME, Allick G, Venema HW, de Haan L, Becker H, van Amelsvoort T, Ackermans MT, Fliers E, Serlie MJM, Sauerwein HP, Hepatic insulin resistance in antipsychotic naive schizophrenic patients: stable isotope studies of glucose metabolism. J CLIN ENDOCR METAB 2008;93 (2):572-577 [PubMed]
Fliers E. Hoofdstuk 17: Endocrinologie van ziekte in: Krenning EP, Wiersinga WM, Lamberts SWJ, Nobels F, Bouillon R, editors. Endocrinologie. S.l.: Elsevier Gezondheidszorg; 2007., p. 352-362
Fliers E. Hoofdstuk 1B: Regelstystemen in de endocrinologie in: Krenning EP, Wiersinga WM, Lamberts SWJ, Nobels F, Bouillon R, editors. Endocrinologie. S.l.: Elsevier Gezondheidszorg; 2007., p. 35
Fliers E, Michels RPJ. Corticosteroïden in: van Everdingen JJE, Glerum JH, editors. Diagnose en Therapie. Jaarboek 2008. Houten: Bohn Stafleu van Loghum; 2007., p. 671-675
Kalsbeek A, Kreier F, Fliers E, Sauerwein HP, Romijn JA, Buijs RM, Minireview: Circadian control of metabolism by the suprachiasmatic nuclei. ENDOCRINOLOGY 2007;148 (12):5635-5639 [PubMed]
Kreier F, Kalsbeek A, Sauerwein HP, Fliers E, Romijn JA, Buijs RM, "Diabetes of the elderly" and type 2 diabetes in younger patients: possible role of the biological clock. EXP GERONTOL 2007;42 (1-2):22-27 [PubMed]
Monajemi H, Stroes E, Hegele RA, Fliers E, Inherited lipodystrophies and the metabolic syndrome. CLIN ENDOCRINOL 2007;67 (4):479-484 [PubMed]
Serlie MJ, Meijer AJ, Groener JE, Duran M, Endert E, Fliers E, Aerts JM, Sauerwein HP, Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects. J CLIN ENDOCR METAB 2007;92 (4):1524-1529 [PubMed]
Soeters MR, Sauerwein HP, Groener JE, Aerts JM, Ackermans MT, Glatz JFC, Fliers E, Serlie MJ, Gender-related differences in the metabolic response to fasting. J CLIN ENDOCR METAB 2007;92 (9):3646-3652 [PubMed]
Thijssen-Timmer DC, Peeters RP, Wouters P, Weekers F, Visser TJ, Fliers E, Wiersinga WM, Bakker O, Berghe GVD, Thyroid hormone receptor isoform expression in livers of critically ill patients. THYROID 2007;17 (2):105-112 [PubMed]
Visser TJ, Fliers E. Thyroid hormones in: Fink G, editor. Encyclopedia of Stress. Oxford: Academic Press; 2007. 3, p. 743-749
Wiersinga WM, Fliers E, Bepaling van schildklierhormoon (T3 en T4) in de urine: een weinig betrouwbare test voor de diagnose 'hypothyreoïdie'. NED TIJDSCHR GENEESKD 2007;151 (51):2813-2815 [PubMed]
Alkemade A, Friesema EC, Kuiper GG, Wiersinga WM, Swaab DF, Visser TJ, Fliers E, Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary. EUR J ENDOCRINOL 2006;154 (3):491-500 [PubMed]
Appelhof BC, Huyser J, Verweij M, Brouwer JP, van Dyck R, Fliers E, Hoogendijk WJG, Tijssen JGP, Wiersinga WM, Schene AH, Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). BIOL PSYCHIAT 2006;59 (8):696-701 [PubMed]
Bisschop PH, Toorians AW, Endert E, Wiersinga WM, Gooren LJ, Fliers E, The effects of sex-steroid administration on the pituitary-thyroid axis in transsexuals. EUR J ENDOCRINOL 2006;155 (1):11-16 [PubMed]
Boelen A, Kwakkel J, Vos XG, Wiersinga WM, Fliers E, Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor beta2 mRNA expression in mice. J ENDOCRINOL 2006;190 (2):537-544 [PubMed]
Boelen A, Kwakkel J, Wiersinga WM, Fliers E, Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake. J ENDOCRINOL 2006;191 (3):707-714 [PubMed]
Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, Anney R, Aneey R, Franke B, Gill M, Ebstein R, Buitelaar J, Sham P, Campbell D, Knight J, Andreou P, Altink M, Arnold R, Boer F, Buschgens C, Butler L, Christiansen H, Feldman L, Fleischman K, Fliers E, Howe-Forbes R, Goldfarb A, Heise A, Gabriëls I, Korn-Lubetzki I, Johansson L, Marco R, Medad S, Minderaa R, Mulas F, Müller U, Mulligan A, Rabin K, Rommelse N, Sethna V, Sorohan J, Uebel H, Psychogiou L, Weeks A, Barrett R, Craig I, Banaschewski T, Sonuga-Barke E, Eisenberg J, Kuntsi J, Manor I, McGuffin P, Miranda A, Oades RD, Plomin R, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Faraone SV, Asherson P, The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. MOL PSYCHIATR 2006;11 (10):934-953 [PubMed]
Brouwer JP, Appelhof BC, Peeters RP, Hoogendijk WJG, Huyser J, Schene AH, Tijssen JGP, van Dyck R, Visser TJ, Wiersinga WM, Fliers E, Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression. EUR J ENDOCRINOL 2006;154 (6):819-825 [PubMed]
Brouwer JP, Appelhof BC, van Rossum EFC, Koper JW, Fliers E, Huyser J, Schene AH, Tijssen JGP, van Dyck R, Lamberts SWJ, Wiersinga WM, Hoogendijk WJG, Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression. PSYCHONEUROENDOCRINO 2006;31 (10):1154-1163 [PubMed]
de Graaff MJ, Buijs RM, Hoekstra JBL, Fliers E, Holleman F, Melatonine: fysiologische en pathofysiologische aspecten en mogelijke toepassingen. NED TIJDSCHR GENEESKD 2006;150 (36):1971-1975 [PubMed]
Endert E, van Rooden M, Fliers E, Prummel MF, Wiersinga WM, Establishment of reference values for endocrine tests--part V: acromegaly. NETH J MED 2006;64 (7):230-235 [PubMed]
Fliers E, Alkemade A, Wiersinga WM, Swaab DF. Hypothalamic thyroid hormone feedback in health and disease in: Kalsbeek A, Fliers E, Hofman MA, Swaab DF, van Someren EJW, Buijs RM, editors. Hypothalamic integration of energy metabolism. Amsterdam: Elsevier; 2006., p. 189-207
Fliers E, Alkemade A, Wiersinga WM, Swaab DF, Hypothalamic thyroid hormone feedback in health and disease. PROG BRAIN RES 2006;153:189-207 [PubMed]
Fliers E, Michels RPJ. Corticosteroiden in: van Everdingen J, Glerum JH, editors. Diagnose en therapie jaarboek 2006. Houten: Bohn Stafleu Van Loghem; 2006., p. 1107-1014
Fliers E, Unmehopa UA, Alkemade A, Functional neuroanatomy of thyroid hormone feedback in the human hypothalamus and pituitary gland. MOL CELL ENDOCRINOL 2006;251 (1-2):1-8 [PubMed]
Kalsbeek A, Fliers E, Hofman MA, Swaab DF, van Someren EJW, Buijs RM, editors, Hypothalamic integration of energy metabolism. Amsterdam: Elsevier; 2006. -p. ISBN 9780444522610 (Progress in Brain Research; 153)
Kreier F, Kap YS, Mettenleiter TC, van Heijningen C, van der Vliet J, Kalsbeek A, Sauerwein HP, Fliers E, Romijn JA, Buijs RM, Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. ENDOCRINOLOGY 2006;147 (3):1140-1147 [PubMed]
Peeters RP, Debaveye Y, Fliers E, Visser TJ, Changes within the thyroid axis during critical illness. CRIT CARE CLIN 2006;22 (1):41-55, vi [PubMed]
Pitteloud N, Meysing A, Quinton R, Acierno JS Jr, Dwyer AA, Plummer L, Fliers E, Boepple P, Hayes F, Seminara S, Hughes VA, Ma J, Bouloux P, Mohammadi M, Crowley WF Jr, Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes. MOL CELL ENDOCRINOL 2006;254-255:60-69 [PubMed]
van Wezel HB, Zuurbier CJ, de Jonge E, van Dam EWCM, van Dijk J, Endert E, de Mol BA, Fliers E, Differential effects of a perioperative hyperinsulinemic normoglycemic clamp on the neurohumoral stress response during coronary artery surgery. J CLIN ENDOCR METAB 2006;91 (10):4144-4153 [PubMed]
Alkemade A, Friesema EC, Unmehopa UA, Fabriek BO, Kuiper GG, Leonard JL, Wiersinga WM, Swaab DF, Visser TJ, Fliers E, Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. J CLIN ENDOCR METAB 2005;90 (7):4322-4334 [PubMed]
Alkemade A, Unmehopa UA, Wiersinga WM, Swaab DF, Fliers E, Glucocorticoids decrease thyrotropin-releasing hormone messenger ribonucleic acid expression in the paraventricular nucleus of the human hypothalamus. J CLIN ENDOCR METAB 2005;90 (1):323-327 [PubMed]
Alkemade A, Vuijst CL, Unmehopa UA, Bakker O, Vennström B, Wiersinga WM, Swaab DF, Fliers E, Thyroid hormone receptor expression in the human hypothalamus and anterior pituitary. J CLIN ENDOCR METAB 2005;90 (2):904-912 [PubMed]
Alkemade JM. Central components of the human hypothalamus-pituarity-thyroid axis and their role in nonthyroidal illness. S.l.: s.n.; 2005. 87p. ISBN 90-9019588-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Swaab DF, Wiersinga WM; copromotor(s): )
Appelhof BC. T3, or no T3 that is the question. Studies in primary hypothyroidism and major depression. Amsterdam: s.n.; 2005. 176p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Wiersinga WM, Hoogendijk WJG; copromotor(s): Fliers E, Schene A)
Appelhof BC, Fliers E, Wekking EM, Schene AH, Huyser J, Tijssen JGP, Endert E, van Weert HCPM, Wiersinga WM, Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. J CLIN ENDOCR METAB 2005;90 (5):2666-2674 [PubMed]
Appelhof BC, Peeters RP, Wiersinga WM, Visser TJ, Wekking EM, Huyser J, Schene AH, Tijssen JGP, Hoogendijk WJG, Fliers E, Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapy. J CLIN ENDOCR METAB 2005;90 (11):6296-6299 [PubMed]
Brouwer JP. Thyroid and adrenal axes in major depression. S.l.: s.n.; 2005. 117p. ISBN - [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Wiersinga WM, Schene AH; copromotor(s): Fliers E, Hoogendijk WJG)
Brouwer JP, Appelhof BC, Hoogendijk WJG, Huyser J, Endert E, Zuketto C, Schene AH, Tijssen JGP, van Dyck R, Wiersinga WM, Fliers E, Thyroid and adrenal axis in major depression: a controlled study in outpatients. EUR J ENDOCRINOL 2005;152 (2):185-191 [PubMed]
Corssmit EPM, Seminara SB, Pitteloud N, Fliers E, Kallmann syndrome in a 47,XXX patient. AM J MED GENET A 2005;139A (1):52-53 [PubMed]
Endert E, Ouwehand A, Fliers E, Prummel MF, Wiersinga WM, Establishment of reference values for endocrine tests. Part IV: adrenal insufficiency. NETH J MED 2005;63 (11):435-443 [PubMed]
Holleman F, Endert E, Prummel MF, van Vessem-Timmermans M, Wiersinga WM, Fliers E, Evaluation of endocrine tests B: screening for hypercortisolism. NETH J MED 2005;63 (9):348-353 [PubMed]
Kalsbeek A, Buijs RM, van Schaik R, Kaptein E, Visser TJ, Doulabi BZ, Fliers E, Daily variations in type II iodothyronine deiodinase activity in the rat brain as controlled by the biological clock. ENDOCRINOLOGY 2005;146 (3):1418-1427 [PubMed]
Klieverik L, Kalsbeek A, Fliers E, Autonomic innervation of the thyroid gland and its functional implications. HOT THYROIDOL 2005;2005 (dec):1
Kreier F. Autonomic nervous control of white adipose tissue. Studies of the role of the brain in body fat distribution. S.l.: s.n.; 2005. 127p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Buijs RM, Fliers E; copromotor(s): Romijn JA, Sauerwein HP)
Romijn JA, Fliers E, Sympathetic and parasympathetic innervation of adipose tissue: metabolic implications. CURR OPIN CLIN NUTR 2005;8 (4):440-444 [PubMed]
Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, Tijssen JGP, Wiersinga WM, Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. EUR J ENDOCRINOL 2005;153 (6):747-753 [PubMed]
Appelhof BC, Brouwer JP, van Dyck R, Fliers E, Hoogendijk WJG, Huyser J, Schene AH, Tijssen JGP, Wiersinga WM, Triiodothyronine addition to paroxetine in the treatment of major depressive disorder. J CLIN ENDOCR METAB 2004;89 (12):6271-6276 [PubMed]
Boelen A, Kwakkel J, Thijssen-Timmer DC, Alkemade A, Fliers E, Wiersinga WM, Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice. J ENDOCRINOL 2004;182 (2):315-323 [PubMed]
Fliers E, Bauer K, Visser T. Thyroid releasing hormone (TRH) in: Encyclopedia of endocrine diseases : vol. 4. San Diego: Elsevier Inc.; 2004., p. 577-580
van Someren EJW, Swart-Heikens J, Endert E, Bisschop PH, Swaab DF, Bakker PJM, Romijn JA, Fliers E, Long-term effects of cranial irradiation for childhood malignancy on sleep in adulthood. EUR J ENDOCRINOL 2004;150 (4):503-510 [PubMed]
Zandieh Doulabi B, Platvoet-ter Schiphorst M, Kalsbeek A, Fliers E, Bakker O, Wiersinga WM, Diurnal variation in rat liver thyroid hormone receptor (TR)-alpha messenger ribonucleic acid (mRNA) is dependent on the biological clock in the suprachiasmatic nucleus, whereas diurnal variation of TR beta 1 mRNA is modified by food intake. ENDOCRINOLOGY 2004;145 (3):1284-1289 [PubMed]
Alkemade A, Unmehopa UA, Brouwer JP, Hoogendijk WJG, Wiersinga WM, Swaab DF, Fliers E, Decreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus of patients with major depression. MOL PSYCHIATR 2003;8 (10):838-839 [PubMed]
Baas SJ, Endert E, Fliers E, Prummel MF, Wiersinga WM, Establishment of reference values for endocrine tests. III: primary aldosteronism. NETH J MED 2003;61 (2):37-43 [PubMed]
Fliers E, Kreier F, Voshol PJ, Havekes LM, Sauerwein HP, Kalsbeek A, Buijs RM, Romijn JA, White adipose tissue: Getting nervous. J NEUROENDOCRINOL 2003;15 (11):1005-1010 [PubMed]
Fliers E, Sauerwein HP, Romijn JA, Reiss P, van der Valk M, Kalsbeek A, Kreier F, Buijs RM, HIV-associated adipose redistribution syndrome as a selective autonomic neuropathy. LANCET 2003;362 (9397):1758-1760 [PubMed]
Fliers E, Wiersinga WM, Myxedema coma. REV ENDOCR METAB DIS 2003;4 (2):137-141 [PubMed]
Fliers E, Wiersinga WM, Screenen van zwangeren op hypothyreoïdie: vooralsnog alleen in hoogrisicogroepen. NED TIJDSCHR GENEESKD 2003;147 (24):1159-1161 [PubMed]
Kreier F, Kalsbeek A, Ruiter M, Yilmaz A, Romijn JA, Sauerwein HP, Fliers E, Buijs RM, Central nervous determination of food storage - a daily switch from conservation to expenditure: implications for the metabolic syndrome. EUR J PHARMACOL 2003;480 (1-3):51-65 [PubMed]
Kreier F, Yilmaz A, Kalsbeek A, Romijn JA, Sauerwein HP, Fliers E, Buijs RM, Hypothesis: Shifting the equilibrium from activity to food leads to autonomic unbalance and the metabolic syndrome. DIABETES 2003;52 (11):2652-2656 [PubMed]
Le Moli R, Endert E, Fliers E, Prummel MF, Wiersinga WM, Evaluation of endocrine tests. A: the TRH test in patients with hyperprolactinaemia. NETH J MED 2003;61 (2):44-48 [PubMed]
Fliers E, Thyroid hormone and depression: on-line. HOT THYROIDOL 2002;2002 (jan):3
Fliers E, Romijn JA, Sauerwein HP, Kalsbeek A, Kreier F, Buijs RM, Vetweefsel: een geïnnerveerde endocriene klier. NED TIJDSCHR GENEESKD 2002;146 (42):1976-1979 [PubMed]
Kreier F, Fliers E, Voshol PJ, van Eden CG, Havekes LM, Kalsbeek A, van Heijningen CL, Sluiter AA, Mettenleiter TC, Romijn JA, Sauerwein HP, Buijs RM, Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J CLIN INVEST 2002;110 (9):1243-1250 [PubMed]
Panayotacopoulou MT, Malidelis YI, Fliers E, Bouras C, Ravid R, Swaab DF, Increased expression of tyrosine hydroxylase immunoreactivity in paraventricular and supraoptic neurons in illnesses with prolonged osmotic or nonosmotic stimulation of vasopressin release. NEUROENDOCRINOLOGY 2002;76 (4):254-266 [PubMed]
Scheer FAJL, van Paassen B, van Montfrans GA, Fliers E, van Someren EJW, van Heerikhuize JJ, Buijs RM, Human basal cortisol levels are increased in hospital compared to home setting. NEUROSCI LETT 2002;333 (2):79-82 [PubMed]
van den Born BJH, Koopmans RP, Fliers E, Hart W, Klinisch denken en beslissen in de praktijk. Onverklaard rectaal bloedverlies bij een patiënte met het multipele-endocriene-neoplasie-1-syndroom. NED TIJDSCHR GENEESKD 2002;146 (15):712-717 [PubMed]
Zandieh Doulabi B, Platvoet-ter Schiphorst M, van Beeren HC, Labruyere WT, Lamers WH, Fliers E, Bakker O, Wiersinga WM, TR(beta)1 protein is preferentially expressed in the pericentral zone of rat liver and exhibits marked diurnal variation. ENDOCRINOLOGY 2002;143 (3):979-984 [PubMed]
Diekman MJ, Zandieh Doulabi B, Platvoet-ter Schiphorst M, Fliers E, Bakker O, Wiersinga WM, The biological relevance of thyroid hormone receptors in immortalized human umbilical vein endothelial cells. J ENDOCRINOL 2001;168 (3):427-433 [PubMed]
Fliers E, Alkemade A, Wiersinga WM, The hypothalamic-pituitary-thyroid axis in critical illness. BEST PRACT RES CL EN 2001;15 (4):453-464 [PubMed]
Fliers E, Unmehopa UA, Manniesing S, Vuijst CL, Wiersinga WM, Swaab DF, Decreased neuropeptide Y (NPY) expression in the infundibular nucleus of patients with nonthyroidal illness. PEPTIDES 2001;22 (3):459-465 [PubMed]
Kalsbeek A, Fliers E, Romijn JA, La Fleur SE, Wortel J, Bakker O, Endert E, Buijs RM, The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. ENDOCRINOLOGY 2001;142 (6):2677-2685 [PubMed]
Heikens J, Ubbink MC, van der Pal HP, Bakker PJ, Fliers E, Smilde TJ, Kastelein JJ, Trip MD, Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. CANCER-AM CANCER SOC 2000;88 (9):2116-2121 [PubMed]
Kalsbeek A, Fliers E, Franke AN, Wortel J, Buijs RM, Functional connections between the suprachiasmatic nucleus and the thyroid gland as revealed by lesioning and viral tracing techniques in the rat. ENDOCRINOLOGY 2000;141 (10):3832-3841 [PubMed]
Swaab DF, Fliers E, Hoogendijk WJ, Veltman DJ, Zhou JN, Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression. PROG BRAIN RES 2000;126:369-396 [PubMed]
Verberne HJ, Fliers E, Prummel MF, Stam J, Brandjes DP, Wiersinga WM, Thyrotoxicosis as a predisposing factor for cerebral venous thrombosis. THYROID 2000;10 (7):607-610 [PubMed]
Le Moli R, Endert E, Fliers E, Mulder T, Prummel MF, Romijn JA, Wiersinga WM, Establishment of reference values for endocrine tests. II: Hyperprolactinemia. NETH J MED 1999;55 (2):71-75 [PubMed]
Alings AM, Fliers E, de Herder WW, Hofland LJ, Sluiter HE, Links TP, van der Hoeven JH, Wiersinga WM, A thyrotropin-secreting pituitary adenoma as a cause of thyrotoxic periodic paralysis. J ENDOCRINOL INVEST 1998;21 (10):703-706 [PubMed]
de Bos Kuil MJ, Endert E, Fliers E, Prummel MF, Romijn JA, Wiersinga WM, Establishment of reference values for endocrine tests. I: Cushing's syndrome. NETH J MED 1998;53 (4):153-163 [PubMed]
Fliers E, Wiersinga WM, Swaab DF, Physiological and pathophysiological aspects of thyrotropin-releasing hormone gene expression in the human hypothalamus. THYROID 1998;8 (10):921-928 [PubMed]
Heikens J, Michiels EM, Behrendt H, Endert E, Bakker PJ, Fliers E, Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma. EUR J CANCER 1998;34 (10):1592-1597 [PubMed]
Fliers E, Guldenaar SE, Wiersinga WM, Swaab DF, Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness. J CLIN ENDOCR METAB 1997;82 (12):4032-4036 [PubMed]
Guldenaar SE, Veldkamp B, Bakker O, Wiersinga WM, Swaab DF, Fliers E, Thyrotropin-releasing hormone gene expression in the human hypothalamus. BRAIN RES 1996;743 (1-2):93-101 [PubMed]
Heikens J, Fliers E, Endert E, Ackermans M, van Montfrans G, Liquorice-induced hypertension--a new understanding of an old disease: case report and brief review. NETH J MED 1995;47 (5):230-234 [PubMed]
Fliers E, Noppen NW, Wiersinga WM, Visser TJ, Swaab DF, Distribution of thyrotropin-releasing hormone (TRH)-containing cells and fibers in the human hypothalamus. J COMP NEUROL 1994;350 (2):311-323 [PubMed]
Fliers E, Düren DR, van Zwieten PA, A prostaglandin analogue as a probable cause of myocardial infarction in a young woman. BMJ-BRIT MED J 1991;302 (6773):416 [PubMed]
Goudsmit E, Hofman MA, Fliers E, Swaab DF, The supraoptic and paraventricular nuclei of the human hypothalamus in relation to sex, age and Alzheimer's disease. NEUROBIOL AGING 1990;11 (5):529-536 [PubMed]
Goudsmit E, Fliers E, Swaab DF, Testosterone supplementation restores vasopressin innervation in the senescent rat brain. BRAIN RES 1988;473 (2):306-313 [PubMed]
Goudsmit E, Fliers E, Swaab DF, Vasopressin and oxytocin excretion in the Brown-Norway rat in relation to aging, water metabolism and testosterone. MECH AGEING DEV 1988;44 (3):241-252 [PubMed]
Hofman MA, Fliers E, Goudsmit E, Swaab DF, Morphometric analysis of the suprachiasmatic and paraventricular nuclei in the human brain: sex differences and age-dependent changes. J ANAT 1988;160:127-143 [PubMed]
Ravid R, Fliers E, Swaab DF, Zurcher C, Changes in vasopressin and testosterone in the senescent brown-Norway (BN/BiRij) rat. GERONTOLOGY 1987;33 (2):87-98 [PubMed]
Fliers E, Guldenaar SE, van de Wal N, Swaab DF, Extrahypothalamic vasopressin and oxytocin in the human brain; presence of vasopressin cells in the bed nucleus of the stria terminalis. BRAIN RES 1986;375 (2):363-367 [PubMed]
Fliers E, Swaab DF, Neuropeptide changes in aging and Alzheimer's disease. PROG BRAIN RES 1986;70:141-152 [PubMed]
Ravid R, Swaab DF, Fliers E, Hoogendijk JE, Verhoogde vasopressine-produktie gedurende ouderdom en dementie. TIJDSCHR GERONTOL GERIATR 1986;17 (4):136-140 [PubMed]
Swaab DF, Fliers E, Clinical strategies in the treatment of Alzheimer's disease. PROG BRAIN RES 1986;70:413-427 [PubMed]
Swaab DF, Fliers E, van Gool WA, Immunocytochemical localization of vasopressin in the human brain; its possible consequences for therapeutic strategies in aging and dementia. PROG BRAIN RES 1986;65:105-113 [PubMed]
Swaab DF, Hofman MA, Fliers E, Seksuele differentiatie van de menselijke hersenen. NED TIJDSCHR GENEESKD 1986;130 (3):106-110 [PubMed]
Fliers E, de Vries GJ, Swaab DF, Changes with aging in the vasopressin and oxytocin innervation of the rat brain. BRAIN RES 1985;348 (1):1-8 [PubMed]
Fliers E, Swaab DF, Pool CW, Verwer RW, The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia. BRAIN RES 1985;342 (1):45-53 [PubMed]
Hoogendijk JE, Fliers E, Swaab DF, Verwer RW, Activation of vasopressin neurons in the human supraoptic and paraventricular nucleus in senescence and senile dementia. J NEUROL SCI 1985;69 (3):291-299 [PubMed]
Swaab DF, Fliers E, A sexually dimorphic nucleus in the human brain. SCIENCE 1985;228 (4703):1112-1115 [PubMed]
Swaab DF, Fliers E, Fisser B, The vasopressin containing neurons in the human brain; changes during ageing and senile dementia. BR J CLIN PRACT SUPPL 1985;39:7-10 [PubMed]
Swaab DF, Fliers E, Partiman TS, The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. BRAIN RES 1985;342 (1):37-44 [PubMed]
Fliers E, Swaab DF, Activation of vasopressinergic and oxytocinergic neurons during aging in the Wistar rat. PEPTIDES 1983;4 (2):165-170 [PubMed]
Key publications

Heinen CA, Losekoot M, Sun Y, Watson PJ, Fairall L, Joustra SD, Zwaveling-Soonawala N, Oostdijk W, van den Akker ELT, Alders M, Santen GWE, van Rijn RR, Dreschler WA, Surovtseva OV, Biermasz NR, Hennekam RC, Wit JM, Schwabe JWR, Boelen A, Fliers E, van Trotsenburg ASP, Mutations in TBL1X Are Associated With Central Hypothyroidism. J CLIN ENDOCR METAB 2016;101 (12):4564-4573 [PubMed]
Fliers E, Bianco AC, Langouche L, Boelen A, Thyroid function in critically ill patients. LANCET DIABETES ENDO 2015;3 (10):816-825 [PubMed]
Kalsbeek A, van der Spek R, Lei J, Endert E, Buijs RM, Fliers E, Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis. MOL CELL ENDOCRINOL 2012;349 (1):20-29 [PubMed]
Alkemade A, Friesema ECH, Kalsbeek A, Swaab DF, Visser TJ, Fliers E, Expression of Thyroid Hormone Transporters in the Human Hypothalamus. J CLIN ENDOCR METAB 2011;96 (6):E967-E971 [PubMed]
Boelen A, Kwakkel J, Fliers E, Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. ENDOCR REV 2011;32 (5):670-693 [PubMed]


All Publications

Research programmes

Neuroendocrinology

 

Themes: Metabolic Disorders and Neurological and Psychiatric Disorders

This research group participates in the Amsterdam Center for Metabolism

Faculty
Prof. dr. E. Fliers
Dr. P.H. Bisschop MD PhD
Dr. A. Boelen
Dr. A.S.P. van Trotsenburg

PhD Students
E. Belegri MSc
Drs. T.M. Boertien MD
D. Daj
M.M. Van Dijk
K.A. van Galen
C.A. Heinen
I.V. Milanova
Drs. J.C. Naafs
Drs. A. Opperhuizen
M. Rijnsburger MSc
Drs. A.H. van der Spek
R.D.C. van der Spek MSc
Drs. N. Zwaveling-Soonawala

Other research related activities
  • Membership of medical or scientific committee, Other, Executive Committee, European Thyroid Association
  • Membership of medical or scientific committee, Other, ENDO ESE International Endocrine Scholars Programme
  • Contribution to guidelines and protocols, ETA guideline committee on Central Hypothyroidism
  • Membership of editorial board / Editorship, ENDOCRINOLOGY
  • Membership of editorial board / Editorship, FRONTIERS IN NEUROSCIENCE
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Ipsen Farmaceutica BV
  • Stg KU Radboud Universiteit Nijmegen
  • Stichting AMC Foundation (Vrijgesteld)
  • ZonMw