Who is Who

  • Principal Investigator
  • Male

Dr. A. Bel

Position: Other
Main activities: Research, Patient care, Teaching
Specialisation: Image guided adaptive radiotherapy, radiation treatment planning
foto A. Bel is one of the AMC Principal Investigators
Focus of research:
  1. Research on image guided adaptive radiotherapy (IGART) is combined with advanced radiation treatment planning. Application of these new treatment techniques are focussing on mobile tumours (e.g. pancreas, oesophagus and bladder).
  2. Main research topics for brachytherapy include: objective criteria to judge the quality of a treatment plan and combination of dose delivered with external beam radiotherapy and brachytherapy with mathematical biological models. Such models enable a prediction of the efficacy of a specific treatment.
  3. Hyperthermia shows some exciting new developments: improved treatment planning and new techniques enabling treatment of new indications. Combined optimization of treatment planning of hyperthermia and radiotherapy is explored; this line includes both fundamental biological research and implementation of mathematical biological models in software.
  4. Our group participates in the Holland  proton therapy center. During the coming years we will design image guided proton irradiation techniques for mobile tumors, a presently unexlored area. The potential benefit of either proton or photon therapy will be explored by means of mathematical biological models, a new application for the models as being developed in our other research lines.
AMC themes: Oncology
Departments: Radiotherapy
de Boer P, van de Schoot AJAJ, Westerveld H, Smit M, Buist MR, Bel A, Rasch CRN, Stalpers LJA, Target tailoring and proton beam therapy to reduce small bowel dose in cervical cancer radiotherapy : A comparison of benefits Zielvolumenpräzisierung und Protonentherapie zur Reduktion der Dünndarmdosis bei der Strahlentherapie des Gebärmutterhalskrebses : Ein Planvergleich. STRAHLENTHER ONKOL 2017;ahead of print [PubMed]
Gurney-Champion OJ. MRI of pancreatic cancer for radiotherapy. S.l.: s.n.; 2017. 244p. ISBN 978-94-028-0546-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Stoker J, Rasch CRN; copromotor(s): Nederveen AJ, Bel A)
Gurney-Champion OJ, Versteijne E, van der Horst A , Lens E, Rütten H, Heerkens HD, Paardekooper GMRM, Berbee M, Rasch CRN, Stoker J, Engelbrecht MRW, van Herk M, Nederveen AJ, Klaassen R, van Laarhoven HWM, van Tienhoven G, Bel A, Addition of MRI for CT-based pancreatic tumor delineation: a feasibility study. ACTA ONCOL 2017;56 (7):923-930 [PubMed]
Houweling AC, Crama K, Visser J, Fukata K, Rasch CRN, Ohno T, Bel A, van der Horst A, Comparing the dosimetric impact of interfractional anatomical changes in photon, proton and carbon ion radiotherapy for pancreatic cancer patients. PHYS MED BIOL 2017;62 (8):3051-3064 [PubMed]
Huijskens SC, van Dijk IWEM, Visser J, Rasch CRN, Alderliesten T, Bel A, Magnitude and variability of respiratory-induced diaphragm motion in children during image-guided radiotherapy. RADIOTHER ONCOL 2017;123 (2):263-269 [PubMed]
Jin P, Hulshof MCCM, van Wieringen N, Bel A, Alderliesten T, Interfractional variability of respiration-induced esophageal tumor motion quantified using fiducial markers and four-dimensional cone-beam computed tomography. RADIOTHER ONCOL 2017;124 (1):147-154 [PubMed]
Lens E. Respiratory motion management for radiotherapy of pancreatic cancer patients. S.l.: s.n.; 2017. 190p. ISBN 9789402806175 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Rasch CRN; copromotor(s): Bel A, van Tienhoven G)
Lens E, Kotte ANTJ, Patel A, Heerkens HD, Bal M, van Tienhoven G, Bel A, van der Horst A , Meijer GJ, Probabilistic treatment planning for pancreatic cancer treatment: prospective incorporation of respiratory motion shows only limited dosimetric benefit. ACTA ONCOL 2017;56 (3):398-404 [PubMed]
Tilly D, van de Schoot AJAJ, Grusell E, Bel A, Ahnesjö A, Dose coverage calculation using a statistical shape model-applied to cervical cancer radiotherapy. PHYS MED BIOL 2017;62 (10):4140-4159 [PubMed]
van der Horst A , Houweling AC, van Tienhoven G, Visser J, Bel A, Dosimetric effects of anatomical changes during fractionated photon radiation therapy in pancreatic cancer patients. J APPL CLIN MED PHYS 2017;ahead of print [PubMed]
van de Schoot AJAJ, de Boer P, Visser J, Stalpers LJA, Rasch CRN, Bel A, Dosimetric advantages of a clinical daily adaptive plan selection strategy compared with a non-adaptive strategy in cervical cancer radiation therapy. ACTA ONCOL 2017;56 (5):667-674 [PubMed]
van Dijk IWEM, Huijskens SC, de Jong R, Visser J, Fajardo RD, Rasch CRN, Alderliesten T, Bel A, Interfractional renal and diaphragmatic position variation during radiotherapy in children and adults: is there a difference?. ACTA ONCOL 2017;56 (8):1065-1071 [PubMed]
van Heerden LE, Houweling AC, Koedooder K, van Kesteren Z, van Wieringen N, Rasch CRN, Pieters BR, Bel A, Structure-based deformable image registration: Added value for dose accumulation of external beam radiotherapy and brachytherapy in cervical cancer. RADIOTHER ONCOL 2017;123 (2):319-324 [PubMed]
van Heerden LE, van Kesteren Z, Gurney-Champion OJ, Houweling AC, Koedooder K, Rasch CRN, Pieters BR, Bel A, Image Distortions on a Plastic Interstitial Computed Tomography/Magnetic Resonance Brachytherapy Applicator at 3 Tesla Magnetic Resonance Imaging and Their Dosimetric Impact. INT J RADIAT ONCOL 2017;99 (3):710-718
van Leeuwen CM, Crezee J, Oei AL, Franken NAP, Stalpers LJA, Bel A, Kok HP, 3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments. INT J HYPERTHER 2017;33 (2):160-169 [PubMed]
van Leeuwen CM, Oei AL, Chin KWTK, Crezee J, Bel A, Westermann AM, Buist MR, Franken NAP, Stalpers LJA, Kok HP, A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer. RADIAT ONCOL 2017;12 (1):75 [PubMed]
van Leeuwen CM, Oei AL, ten Cate R, Franken NAP, Bel A, Stalpers LJA, Crezee J, Kok HP, Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation. INT J HYPERTHER 2017;ahead of print [PubMed]
Versteijne E, Gurney-Champion OJ, van der Horst A , Lens E, Kolff MW, Buijsen J, Ebrahimi G, Neelis KJ, Rasch CRN, Stoker J, van Herk M, Bel A, van Tienhoven G, Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT: a multi-institutional study. RADIAT ONCOL 2017;12 (1):58 [PubMed]
Versteijne E, Lens E, van der Horst A , Bel A, Visser J, Punt CJA, Suker M, van Eijck CHJ, van Tienhoven G, Quality assurance of the PREOPANC trial (2012-003181-40) for preoperative radiochemotherapy in pancreatic cancer : The dummy run Qualitätssicherung in der PREOPANC-Studie (2012-003181-40) für die präoperative Radiochemotherapie beim Pankreaskarzinom : Der „dummy run“. STRAHLENTHER ONKOL 2017;193 (8):630-638 [PubMed]
Crezee H, van Leeuwen CM, Oei AL, Stalpers LJA, Bel A, Franken NA, Kok HP, Thermoradiotherapy planning: Integration in routine clinical practice. INT J HYPERTHER 2016;32 (1):41-49 [PubMed]
Crezee J, van Leeuwen CM, Oei AL, van Heerden LE, Bel A, Stalpers LJA, Ghadjar P, Franken NAP, Kok HP, Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer. RADIAT ONCOL 2016;11 (1):14 [PubMed]
de Jong R, Lutkenhaus L, van Wieringen N, Visser J, Wiersma J, Crama K, Geijsen D , Bel A, Plan selection strategy for rectum cancer patients: An interobserver study to assess clinical feasibility. RADIOTHER ONCOL 2016;120 (2):207-211 [PubMed]
Gurney-Champion OJ, Bruins Slot T, Lens E, van der Horst A , Klaassen R, van Laarhoven HWM, van Tienhoven G, van Hooft JE, Nederveen AJ, Bel A, Quantitative assessment of biliary stent artifacts on MR images: Potential implications for target delineation in radiotherapy. MED PHYS 2016;43 (10):5603 [PubMed]
Gurney-Champion OJ, Froeling M, Klaassen R, Runge JH, Bel A, van Laarhoven HWM, Stoker J, Nederveen AJ, Minimizing the Acquisition Time for Intravoxel Incoherent Motion Magnetic Resonance Imaging Acquisitions in the Liver and Pancreas. INVEST RADIOL 2016;51 (4):211-220 [PubMed]
Gurney-Champion OJ, Nederveen AJ, Klaassen R, Engelbrecht MR, Bel A, van Laarhoven HWM, Stoker J, Goncalves SI, Revisiting the Potential of Alternating Repetition Time Balanced Steady-State Free Precession Imaging of the Abdomen at 3 T. INVEST RADIOL 2016;51 (9):560-568 [PubMed]
Houweling AC, de Vries JHW, Wolthaus J, Woodings S, Kok JGM, van Asselen B, Smit K, Bel A, Lagendijk JJW, Raaymakers BW, Performance of a cylindrical diode array for use in a 1.5 T MR-linac. PHYS MED BIOL 2016;61 (3):N80-N89 [PubMed]
Houweling AC, Fukata K, Kubota Y, Shimada H, Rasch CRN, Ohno T, Bel A, van der Horst A, The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients. RADIOTHER ONCOL 2016;119 (2):319-325 [PubMed]
Jin P, Hulshof MCCM, de Jong R, van Hooft JE, Bel A, Alderliesten T, Quantification of respiration-induced esophageal tumor motion using fiducial markers and four-dimensional computed tomography. RADIOTHER ONCOL 2016;118 (3):492-497 [PubMed]
Lens E, Gurney-Champion OJ, Tekelenburg DR, van Kesteren Z, Parkes MJ, van Tienhoven G, Nederveen AJ, van der Horst A , Bel A, Abdominal organ motion during inhalation and exhalation breath-holds: pancreatic motion at different lung volumes compared. RADIOTHER ONCOL 2016;121 (2):268-275 [PubMed]
Lens E, van der Horst A , Versteijne E, Bel A, van Tienhoven G, Considerable pancreatic tumor motion during breath-holding. ACTA ONCOL 2016;55 (11):1360-1368 [PubMed]
Lutkenhaus L. Potential benefit and clinical implementation of adaptive radiotherapy. S.l.: s.n.; 2016. 169p. ISBN 978-94-028-0309-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Rasch CRN; copromotor(s): Bel A, Hulshof MCCM)
Lutkenhaus LJ , de Jong R, Geijsen ED, Visser J, van Wieringen N, Bel A, Potential dosimetric benefit of an adaptive plan selection strategy for short-course radiotherapy in rectal cancer patients. RADIOTHER ONCOL 2016;119 (3):525-530 [PubMed]
Lutkenhaus LJ , van Os RM, Bel A, Hulshof MCCM, Clinical results of conformal versus intensity-modulated radiotherapy using a focal simultaneous boost for muscle-invasive bladder cancer in elderly or medically unfit patients. RADIAT ONCOL 2016;11 (1):45 [PubMed]
Lutkenhaus LJ, Vestergaard A, Bel A, Høyer M, Hulshof MCCM, van Leeuwen CM, Casares-Magaz O, Petersen JB, Søndergaard J, Muren LP, A biological modeling based comparison of two strategies for adaptive radiotherapy of urinary bladder cancer. ACTA ONCOL 2016;55 (8):1009-1015 [PubMed]
Parkes MJ, Green S, Cashmore J, Stevens AM, Clutton-Brock TH, Bel A, Lens E, Lohr F, Boda-Heggemann J, In Regard to Boda-Heggemann et al. INT J RADIAT ONCOL 2016;96 (3):709-710 [PubMed]
van de Schoot AJAJ. Optimization of adaptive radiation therapy in cervical cancer: Solutions for photon and proton therapy. S.l.: s.n.; 2016. 181p. ISBN 978-94-028-0148-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Rasch CRN; copromotor(s): Bel A, Stalpers LJA)
van de Schoot AJAJ, de Boer P, Crama KF, Visser J, Stalpers LJA, Rasch CRN, Bel A, Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer. ACTA ONCOL 2016;55 (7):892-899 [PubMed]
van de Schoot AJAJ, Visser J, van Kesteren Z, Janssen TM, Rasch CRN, Bel A, Beam configuration selection for robust intensity-modulated proton therapy in cervical cancer using Pareto front comparison. PHYS MED BIOL 2016;61 (4):1780-1794 [PubMed]
van Heerden LE, Gurney-Champion OJ, van Kesteren Z, Houweling AC, Koedooder C, Rasch CRN, Pieters BR, Bel A, Quantification of image distortions on the Utrecht interstitial CT/MR brachytherapy applicator at 3T MRI. BRACHYTHERAPY 2016;15 (1):118-126 [PubMed]
Dinkla AM. Stepping source prostate brachytherapy: From target definition to dose delivery. S.l.: s.n.; 2015. 162p. ISBN 978-94-6259-552-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Rasch CRN; copromotor(s): Bel A, Pieters BR, van der Laarse R)
Dinkla AM, van der Laarse R, Kaljouw E, Pieters BR, Koedooder K, van Wieringen N, Bel A, A comparison of inverse optimization algorithms for HDR/PDR prostate brachytherapy treatment planning. BRACHYTHERAPY 2015;14 (2):279-288 [PubMed]
Dinkla AM, van der Laarse R, Koedooder K, Petra Kok H, van Wieringen N, Pieters BR, Bel A, Novel tools for stepping source brachytherapy treatment planning: enhanced geometrical optimization and interactive inverse planning. MED PHYS 2015;42 (1):348-353 [PubMed]
Gurney-Champion OJ, Lens E, van der Horst A , Houweling AC, Klaassen R, van Hooft JE, Stoker J, van Tienhoven G, Nederveen AJ, Bel A, Visibility and artifacts of gold fiducial markers used for image guided radiation therapy of pancreatic cancer on MRI. MED PHYS 2015;42 (5):2638-2647 [PubMed]
Haj Mohammad N , Kamphuis M, Hulshof MCCM, Lutkenhaus LJ , Gisbertz SS, Bergman JJGHM, de Bruin-Bon HACMR, Geijsen ED, Bel A, Boekholdt SM, van Laarhoven HWM, Reduction of heart volume during neoadjuvant chemoradiation in patients with resectable esophageal cancer. RADIOTHER ONCOL 2015;114 (1):91-95 [PubMed]
Huijskens SC, van Dijk IWEM, de Jong R, Visser J, Fajardo RD, Ronckers CM, Janssens GORJ, Maduro JH, Rasch CRN, Alderliesten T, Bel A, Quantification of renal and diaphragmatic interfractional motion in pediatric image-guided radiation therapy: A multicenter study. RADIOTHER ONCOL 2015;117 (3):425-431 [PubMed]
Jin P, van der Horst A , de Jong R, van Hooft JE, Kamphuis M, van Wieringen N, Machiels M, Bel A, Hulshof MCCM, Alderliesten T, Marker-based quantification of interfractional tumor position variation and the use of markers for setup verification in radiation therapy for esophageal cancer. RADIOTHER ONCOL 2015;117 (3):412-418 [PubMed]
Lens E, van der Horst A , Versteijne E, van Tienhoven G, Bel A, Dosimetric Advantages of Midventilation Compared With Internal Target Volume for Radiation Therapy of Pancreatic Cancer. INT J RADIAT ONCOL 2015;92 (3):675-682 [PubMed]
Lutkenhaus LJ , Kamphuis M, van Wieringen N, Hulshof MCCM, Bel A, Regarding Edmunds et al. Cardiac volume effects during chemoradiotherapy for esophageal cancer. RADIOTHER ONCOL 2015;114 (1):130 [PubMed]
Lutkenhaus LJ , Visser J, de Jong R, Hulshof MCCM, Bel A, Evaluation of delivered dose for a clinical daily adaptive plan selection strategy for bladder cancer radiotherapy. RADIOTHER ONCOL 2015;116 (1):51-56 [PubMed]
van de Schoot AJAJ, de Boer P, Buist MR, Stoker J, Bleeker MCG, Stalpers LJA, Rasch CRN, Bel A, Quantification of delineation errors of the gross tumor volume on magnetic resonance imaging in uterine cervical cancer using pathology data and deformation correction. ACTA ONCOL 2015;54 (2):224-231 [PubMed]
Alderliesten T, Bosman PAN, Sonke JJ, Bel A, A multi-resolution strategy for amulti-objective deformable image registration framework that accomodates large anatomical differences. PROC SPIE 2014;9034:90343G--
Alderliesten T, Hulshof MC, Bel A, De ontwikkeling en mogelijkheden van beeldgeleide radiotherapie. NED TIJDSCHR ONCOL 2014;11 (1):13-19
Dávila Fajardo R , Lekkerkerker SJ, van der Horst A , Lens E, Bergman JJ, Fockens P, Bel A, van Hooft JE, EUS-guided fiducial markers placement with a 22-gauge needle for image-guided radiation therapy in pancreatic cancer. GASTROINTEST ENDOSC 2014;79 (5):851-855 [PubMed]
Dinkla AM, Pieters BR, Koedooder K, van Wieringen N, van der Laarse R, Bel A, Prostate volume and implant configuration during 48 hours of temporary prostate brachytherapy: limited effect of oedema. RADIAT ONCOL 2014;9 (1):272 [PubMed]
Kok HP, Ciampa S, de Kroon-Oldenhof R, Steggerda-Carvalho EJ, van Stam G, Zum Vörde Sive Vörding PJ, Stalpers LJA, Geijsen ED, Bardati F, Bel A, Crezee J, Toward online adaptive hyperthermia treatment planning: correlation between measured and simulated specific absorption rate changes caused by phase steering in patients. INT J RADIAT ONCOL 2014;90 (2):438-445 [PubMed]
Kok HP, Crezee J, Franken NAP, Stalpers LJA, Barendsen GW, Bel A, Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions. INT J RADIAT ONCOL 2014;88 (3):739-745 [PubMed]
Lens E, van der Horst A , Kroon PS, van Hooft JE, Dávila Fajardo R , Fockens P, van Tienhoven G, Bel A, Differences in respiratory-induced pancreatic tumor motion between 4D treatment planning CT and daily cone beam CT, measured using intratumoral fiducials. ACTA ONCOL 2014;53 (9):1257-1264 [PubMed]
van der Horst A , Lens E, Wognum S, de Jong R, van Hooft JE, van Tienhoven G, Bel A, Limited role for biliary stent as surrogate fiducial marker in pancreatic cancer: stent and intratumoral fiducials compared. INT J RADIAT ONCOL 2014;89 (3):641-648 [PubMed]
van de Schoot AJAJ, Schooneveldt G, Wognum S, Hoogeman MS, Chai X, Stalpers LJA, Rasch CRN, Bel A, Generic method for automatic bladder segmentation on cone beam CT using a patient-specific bladder shape model. MED PHYS 2014;41 (3):031707 [PubMed]
Wognum S, Heethuis SE, Rosario T, Hoogeman MS, Bel A, Validation of deformable image registration algorithms on CT images of ex vivo porcine bladders with fiducial markers. MED PHYS 2014;41 (7):071916 [PubMed]
Dinkla AM, Pieters BR, Koedooder K, Meijnen P, van Wieringen N, van der Laarse R, van der Grient JN, Rasch CRN, Bel A, Deviations from the planned dose during 48 hours of stepping source prostate brachytherapy caused by anatomical variations. RADIOTHER ONCOL 2013;107 (1):106-111 [PubMed]
Dinkla AM, Pieters BR, Koedooder K, van Wieringen N, van der Laarse R, van der Grient JN, Rasch CR, Koning CC, Bel A, Improved tumour control probability with MRI-based prostate brachytherapy treatment planning. ACTA ONCOL 2013;52 (3):658-665 [PubMed]
Kok HP, van den Berg CAT, Bel A, Crezee J, Fast thermal simulations and temperature optimization for hyperthermia treatment planning, including realistic 3D vessel networks. MED PHYS 2013;40 (10):103303 [PubMed]
Lutkenhaus LJ , Kamphuis M, van Wieringen N, Hulshof MCCM, Bel A, Reduction in cardiac volume during chemoradiotherapy for patients with esophageal cancer. RADIOTHER ONCOL 2013;109 (2):200-203 [PubMed]
van der Horst A , Wognum S, Dávila Fajardo R , de Jong R, van Hooft JE, Fockens P, van Tienhoven G, Bel A, Interfractional position variation of pancreatic tumors quantified using intratumoral fiducial markers and daily cone beam computed tomography. INT J RADIAT ONCOL 2013;87 (1):202-208 [PubMed]
Wognum S, Bondar L, Zolnay AG, Chai X, Hulshof MCCM, Hoogeman MS, Bel A, Control over structure-specific flexibility improves anatomical accuracy for point-based deformable registration in bladder cancer radiotherapy. MED PHYS 2013;40 (2):021702 [PubMed]
Althof V, van Haaren P, Westendorp R, Nuver T, Kramer D, Ikink M, Bel A, Minken A, A quality assurance tool for helical tomotherapy using a step-wedge phantom and the on-board MVCT detector. J APPL CLIN MED PHYS 2012;13 (1):148-163 [PubMed]
Chai X. Building tools for image-guided adaptive radiotherapy of bladder cancer. BOXPress: Oisterwijk; 2012. 142p. ISBN 9789088914188 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Herk MB, Koning CCE; copromotor(s): Bel A)
Chai X, van Herk M, Betgen A, Hulshof M, Bel A, Automatic bladder segmentation on CBCT for multiple plan ART of bladder cancer using a patient-specific bladder model. PHYS MED BIOL 2012;57 (12):3945-3962 [PubMed]
Chai X, van Herk M, Betgen A, Hulshof M, Bel A, Semiautomatic bladder segmentation on CBCT using a population-based model for multiple-plan ART of bladder cancer. PHYS MED BIOL 2012;57 (24):N525-N541 [PubMed]
Chai X, van Herk M, Hulshof MCCM, Bel A, A voxel-based finite element model for the prediction of bladder deformation. MED PHYS 2012;39 (1):55-65 [PubMed]
Stippel G, van Rooijen DC, Crezee J, Bel A, Automatic delineation of body contours on cone-beam CT images using a delineation booster. PHYS MED BIOL 2012;57 (13):N225-N236 [PubMed]
van Rooijen D. Improving radiation dose delivery for moving targets using image guidance. s.l.: s.n.; 2012. 134p. ISBN 9789088914126 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Koning CCE; copromotor(s): Bel A, Hulshof MCCM)
van Rooijen DC, van Wieringen N, Stippel G, Crezee J, Koning CCE, Bel A, Dose-Guided Radiotherapy: Potential Benefit of Online Dose Recalculation for Stereotactic Lung Irradiation in Patients With Non-Small-Cell Lung Cancer. INT J RADIAT ONCOL 2012;83 (4):E557-E562 [PubMed]
Chai X, van Herk M, van de Kamer JB, Hulshof MCCM, Remeijer P, Lotz HT, Bel A, Finite element based bladder modeling for image-guided radiotherapy of bladder cancer. MED PHYS 2011;38 (1):142-150 [PubMed]
de Greef M, Kok HP, Bel A, Crezee J, 3D versus 2D steering in patient anatomies: A comparison using hyperthermia treatment planning. INT J HYPERTHER 2011;27 (1):74-85 [PubMed]
de Greef M, Kok HP, Correia D , Borsboom PP, Bel A, Crezee J, Uncertainty in hyperthermia treatment planning: the need for robust system design. PHYS MED BIOL 2011;56 (11):3233-3250 [PubMed]
Kok HP, de Greef M, Borsboom PP, Bel A, Crezee J, Improved power steering with double and triple ring waveguide systems: The impact of the operating frequency. INT J HYPERTHER 2011;27 (3):224-239 [PubMed]
Chai X, van Herk M, van de Kamer JB, Remeijer P, Bex A, Betgen A, de Reijke TM, Hulshof MCCM, Pos FJ, Bel A, BEHAVIOR OF LIPIODOL MARKERS DURING IMAGE GUIDED RADIOTHERAPY OF BLADDER CANCER. INT J RADIAT ONCOL 2010;77 (1):309-314 [PubMed]
de Greef M, Kok HP, Correia D , Bel A, Crezee J, Optimization in hyperthermia treatment planning: the impact of tissue perfusion uncertainty. MED PHYS 2010;37 (9):4540-4550 [PubMed]
Kok HP, de Greef M, Wiersma J, Bel A, Crezee J, The impact of the waveguide aperture size of the 3D 70 MHz AMC-8 locoregional hyperthermia system on tumour coverage. PHYS MED BIOL 2010;55 (17):4899-4916 [PubMed]
Petra Kok H, Correia D, de Greef M, van Stam G, Bel A, Crezee J, SAR deposition by curved CFMA-434 applicators for superficial hyperthermia: Measurements and simulations. INT J HYPERTHER 2010;26 (2):171-184 [PubMed]
Petra Kok H, de Greef M, van Wieringen N, Correia D, Hulshof MCCM, Zum Vörde Sive Vörding PJ, Sijbrands J, Bel A, Crezee J, Comparison of two different 70 MHz applicators for large extremity lesions: Simulation and application. INT J HYPERTHER 2010;26 (4):376-388 [PubMed]
van Rooijen DC, Pool R, van de Kamer JB, Hulshof MCCM, Koning CCE, Bel A, Independent position correction on tumor and lymph nodes; consequences for bladder cancer irradiation with two combined IMRT plans. RADIAT ONCOL 2010;5:53 [PubMed]
van Rooijen DC, van de Kamer JB, Hulshof MCCM, Koning CCE, Bel A, Improving bladder cancer treatment with radiotherapy using separate intensity modulated radiotherapy plans for boost and elective fields. J MED IMAG RADIAT ON 2010;54 (3):256-263 [PubMed]
Correia D, Kok HP, de Greef M, Bel A, van Wieringen N, Crezee J, Body conformal antennas for superficial hyperthermia: the impact of bending contact flexible microstrip applicators on their electromagnetic behavior. IEEE T BIO-MED ENG 2009;56 (12):2917-2926 [PubMed]
Crezee J, van Haaren PMA, Westendorp H, de Greef M, Kok HP, Wiersma J, van Stam G, Sijbrands J, Zum Vörde Sive Vörding P, van Dijk JDP, Hulshof MCCM, Bel A, Improving locoregional hyperthermia delivery using the 3-D controlled AMC-8 phased array hyperthermia system: A preclinical study. INT J HYPERTHER 2009;25 (7):581-592 [PubMed]
de Greef M, Crezee J, van Eijk JC, Pool R, Bel A, Accelerated ray tracing for radiotherapy dose calculations on a GPU. MED PHYS 2009;36 (9):4095-4102 [PubMed]
Kok HP, de Greef M, Bel A, Crezee J, Acceleration of high resolution temperature based optimization for hyperthermia treatment planning using element grouping. MED PHYS 2009;36 (8):3795-3805 [PubMed]
Kok HP, de Greef M, Correia D, Zum Vorde Sive Vording PJ, van Stam G, Gelvich EA, Bel A, Crezee J, FDTD simulations to assess the performance of CFMA-434 applicators for superficial hyperthermia. INT J HYPERTHER 2009;25 (6):462-476 [PubMed]
Lips IM, van der Heide UA, Kotte ANTJ, van Vulpen M, Bel A, Effect of translational and rotational errors on complex dose distributions with off-line and on-line position verification. INT J RADIAT ONCOL 2009;74 (5):1600-1608 [PubMed]
van Haaren PMA, Bel A, Hofman P, van Vulpen M, Kotte ANTJ, van der Heide UA, Influence of daily setup measurements and corrections on the estimated delivered dose during IMRT treatment of prostate cancer patients. RADIOTHER ONCOL 2009;90 (3):291-298 [PubMed]
van Rooijen DC, van de Kamer JB, Pool R, Hulshof MCCM, Koning CCE, Bel A, The effect of on-line position correction on the dose distribution in focal radiotherapy for bladder cancer. RADIAT ONCOL 2009;4 (1):38 [PubMed]
van Herten YRJ, van de Kamer JB, van Wieringen N, Pieters BR, Bel A, Dosimetric evaluation of prostate rotations and their correction by couch rotations. RADIOTHER ONCOL 2008;88 (1):156-162 [PubMed]
Hulshof MCCM, van Andel G, Bel A, Gangel P, van de Kamer JB, Intravesical markers for delineation of target volume during external focal irradiation of bladder carcinomas. RADIOTHER ONCOL 2007;84 (1):49-51 [PubMed]
Astreinidou E, Bel A, Raaijmakers CPJ, Terhaard CHJ, Lagendijk JJW, Adequate margins for random setup uncertainties in head-and-neck IMRT. INT J RADIAT ONCOL 2005;61 (3):938-944 [PubMed]
van de Steene J, Linthout N, de Mey J, Vinh-Hung V, Claassens C, Noppen M, Bel A, Storme G, Definition of gross tumor volume in lung cancer: inter-observer variability. RADIOTHER ONCOL 2002;62 (1):37-49 [PubMed]
Bel A, Petrascu O, van de Vondel I, Coppens L, Linthout N, Verellen D, Storme G, A computerized remote table control for fast on-line patient repositioning: implementation and clinical feasibility. MED PHYS 2000;27 (2):354-358 [PubMed]
Linthout N, Verellen D, de Coninck P, Bel A, Storme G, Radiothérapie conformationnelle: la tomothérapie. CANCER RADIOTHER 2000;4 (6):433-442 [PubMed]
Petrascu O, Bel A, Linthout N, Verellen D, Soete G, Storme G, Automatic on-line electronic portal image analysis with a wavelet-based edge detector. MED PHYS 2000;27 (2):321-329 [PubMed]
Verellen D, Linthout N, Bel A, Soete G, van den Berge D, D' Haens J, Storme G, Assessment of the uncertainties in dose delivery of a commercial system for linac-based stereotactic radiosurgery. INT J RADIAT ONCOL 1999;44 (2):421-433 [PubMed]
Verellen D, Vinh-Hung V, Bijdekerke P, Nijs F, Linthout N, Bel A, Storme G, Characteristics and clinical application of a treatment simulator with Ct-option. RADIOTHER ONCOL 1999;50 (3):355-366 [PubMed]
van de Steene J, van den Heuvel F, Bel A, Verellen D, de Mey J, Noppen M, de Beukeleer M, Storme G, Electronic portal imaging with on-line correction of setup error in thoracic irradiation: clinical evaluation. INT J RADIAT ONCOL 1998;40 (4):967-976 [PubMed]
van de Vondel I, Coppens L, Verellen D, Bel A, Linthout N, de Beukeleer M, van den Berge D, Storme G, Microprocessor controlled limitation system for a stand-alone freely movable treatment couch. MED PHYS 1998;25 (6):897-899 [PubMed]
Verellen D, Linthout N, van den Berge D, Bel A, Storme G, Initial experience with intensity-modulated conformal radiation therapy for treatment of the head and neck region. INT J RADIAT ONCOL 1997;39 (1):99-114 [PubMed]
Bel A, van Herk M, Lebesque JV, Target margins for random geometrical treatment uncertainties in conformal radiotherapy. MED PHYS 1996;23 (9):1537-1545 [PubMed]
Bel A, Vos PH, Rodrigus PT, Creutzberg CL, Visser AG, Stroom JC, Lebesque JV, High-precision prostate cancer irradiation by clinical application of an offline patient setup verification procedure, using portal imaging. INT J RADIAT ONCOL 1996;35 (2):321-332 [PubMed]
Bel A, Keus R, Vijlbrief RE, Lebesque JV, Setup deviations in wedged pair irradiation of parotid gland and tonsillar tumors, measured with an electronic portal imaging device. RADIOTHER ONCOL 1995;37 (2):153-159 [PubMed]
van Herk M, Bel A, Gilhuijs KG, Lebesque JV, van Dalen A, van der Ven P, Vijlbrief R, Electronic portal imaging. B CANCER 1995;82 (Suppl. 5):601s-606s [PubMed]
Bel A, Bartelink H, Vijlbrief RE, Lebesque JV, Transfer errors of planning CT to simulator: a possible source of setup inaccuracies?. RADIOTHER ONCOL 1994;31 (2):176-180 [PubMed]
Bel A, van Herk M, Bartelink H, Lebesque JV, A verification procedure to improve patient set-up accuracy using portal images. RADIOTHER ONCOL 1993;29 (2):253-260 [PubMed]
el-Gayed AA, Bel A, Vijlbrief R, Bartelink H, Lebesque JV, Time trend of patient setup deviations during pelvic irradiation using electronic portal imaging. RADIOTHER ONCOL 1993;26 (2):162-171 [PubMed]
van Herk M, Bel A, Gilhuijs KG, Vijlbrief RE, A comprehensive system for the analysis of portal images. RADIOTHER ONCOL 1993;29 (2):221-229 [PubMed]
Blom J, ter Haar Romeny BM, Bel A, Koenderink JJ, Spatial derivatives and the propagation of noise in Gaussian scale space. J VIS COMMUN IMAGE R 1992;4 (1):1-13
Lebesque JV, Bel A, Bijhold J, Hart AA, Detection of systematic patient setup errors by portal film analysis. RADIOTHER ONCOL 1992;23 (3):198 [PubMed]
Key publications

van der Horst A , Wognum S, Dávila Fajardo R , de Jong R, van Hooft JE, Fockens P, van Tienhoven G, Bel A, Interfractional position variation of pancreatic tumors quantified using intratumoral fiducial markers and daily cone beam computed tomography. INT J RADIAT ONCOL 2013;87 (1):202-208 [PubMed]
Wognum S, Heethuis SE, Rosario T, Hoogeman MS, Bel A, Validation of deformable image registration algorithms on CT images of ex vivo porcine bladders with fiducial markers. MED PHYS 2014;41 (7):071916 [PubMed]
Lutkenhaus LJ , Visser J, de Jong R, Hulshof MCCM, Bel A, Evaluation of delivered dose for a clinical daily adaptive plan selection strategy for bladder cancer radiotherapy. RADIOTHER ONCOL 2015;116 (1):51-56 [PubMed]
Kok HP, Crezee J, Franken NAP, Stalpers LJA, Barendsen GW, Bel A, Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions. INT J RADIAT ONCOL 2014;88 (3):739-745 [PubMed]
Dinkla AM, van der Laarse R, Kaljouw E, Pieters BR, Koedooder K, van Wieringen N, Bel A, A comparison of inverse optimization algorithms for HDR/PDR prostate brachytherapy treatment planning. BRACHYTHERAPY 2015;14 (2):279-288 [PubMed]


All Publications

Curriculum Vitae

Personal details

Name: dr. Arjan (Adrianus) Bel
Gender: male
Date of birth: 23-1-1966
Place of birth: Leerdam, Netherlands
Nationality: Dutch

Education

PHD degree
Institute: Antoni van Leeuwenhoek Huis
Date: 1991-1995
PhD degree: February 1996, (Vrije Universiteit, Amsterdam)
Daily supervisors: dr. J. Lebesque, dr. M. van Herk, promotor: prof. dr. H. Bartelink.
PhD thesis: “Conformal radiotherapy: hitting a moving target.” Study on image guided improvement of positional accuracy of patients during radiotherapy.

Master degree

University: Utrecht
Date: 1984-1990
Study: Physics, specialization: computational physics/medical image processing
Master thesis: “Detection of edges and corners.” Study on automatic recognition of structures in MRI and CT images.

Other education
Hospital physicist Belgium 2000 (until 2004).
Clinical physicist The Netherlands, 2006.
Various courses on management in health care (2005-2009).

 

Professional experience

Sept. 2004 – present: head radiotherapy physics, Academisch Medisch Centrum, Amsterdam.

  • General management of HR (~45 fte, including project workers).
  • Coordination and management of clinical physics tasks.
  • Involvement in financial management/investments at department level (annual budget ~17M).
  • Hands-on clinical work.

Research/education

  • Started a research group from scratch.
  • Involvement in strategic coordination of department’s research direction.
  • Supervision of >30 BS/MS students.
  • Co-supervisor for 7 PhD students (finalized) + 10 PhD students (ongoing)

1999 – 2004: physicist/software engineer, Nucletron B.V., Veenendaal, Netherlands.


Development of treatment planning system for external beam radiotherapy; link between international customers/ users (Radiotherapy departments) and industrial R&D.

995-1999: Clinical physicist.


UZ Brussels, dept. of radiotherapy, Brussels, Belgium .
Physics support of the clinic, introduction of new developments for imaging and treatment planning for clinical use.

1991-1995: PhD student at NKI/AvL, Amsterdam.
See: Education.

1990-1991: Software engineer
Assignment on various software projects via employment agency.
research (2004-present)

 

Memberships

  • European society for radiotherapy and oncology (ESTRO).
  • Paediatric Radiation Oncology Society (PROS).
  • Nederlands vereniging voor klinische fysica (NVKF).
  • Nederlandse vereniging voor radiotherapie en oncologie (NVRO).

Awards and prize-winning grants


Senior author of award winning studies:
1. ESTRO-Jack Fowler award Barcelona "On-line dose calculation on cone beam CT for lung tumors", DC van Rooijen, G. Stippel, N. van Wieringen, A. Bel, 2010
2. ESTRO best poster award Barcelona "Prostate PDR brachytherapy: is it necessary to use an adaptive approach?" A Dinkla, P. Meijnen, B.R. Pieters, C. Koedooder, N. van Wieringen, R. van der Laarse, J.N. van der Grient, A. Bel, 2012
3. ESTRO best poster award Geneva "Cardiac volume reduction during chemo-radiotherapy of esophageal cancer patients" M. Kamphuis, LJ. Lutkenhaus, N. van Wieringen, MCCM Hulshof, A. Bel, 2013
4. ESTRO-Accuray Award, Vienna “Considerable intra-breath-hold motion and inter-breath-hold position variation of pancreatic tumors.” E. Lens, A van der Horst, E Versteijne, G van Tienhoven, A. Bel 2015
5. Best session presentation, Amsterdam Children Symposium “Radiotherapy in children, is there a difference with adults?” S.C. Huijskens, I.W.E.M van Dijk, M.A.J. de Jong, J. Visser, R. Dávila Fajardo, C.R.N. Rasch, T. Alderliesten, A. Bel, 2016
6. Session winning Award Amsterdam Kindersymposium “Respiratory-induced diaphragm motion during radiotherapy” S.C. Huijskens, I.W.E.M van Dijk, M.A.J. de Jong, J. Visser, R. Dávila Fajardo, C.R.N. Rasch, T. Alderliesten, A. Bel, 2017
7. Best presentation Award, First Quantivision symposium, Amsterdam “Dose warping uncertainties for the cumulative rectal wall dose from brachytherapy in cervical cancer” L. van Heerden, N. van Wieringen‎, C. Koedooder‎, B.R. Pieters‎, C.R.N. Rasch‎, A. Bel , 2017
8. 2nd prize best poster Award, First Quantivision symposium, Amsterdam “Comparison of respiratory-induced motion during radiotherapy between children and adults” S.C. Huijskens, I.W.E.M van Dijk, J. Visser, C.R.N. Rasch, T. Alderliesten, A. Bel 2017
9. ESTRO Junior Brachytherapy Travel Grant Vienna “ Dose warping uncertainties for the cumulative rectal wall dose from brachytherapy in cervical cancer” L. van Heerden, N. van Wieringen‎, C. Koedooder‎, B.R. Pieters‎, C.R.N. Rasch‎, A. Bel , 2017

 

Various other activities

  • Reviewer for leading papers in the field: International Journal of Radiation Oncology, Biology, Physics; Medical Physics; Physics in Medicine and Biology; Radiation Oncology; Radiotherapy and Oncology; British Journal of Radiology.
  • Reviewer for funding organizations (Cancer UK, KWF).
  • Reviewer and chairman for a number of international conferences (i.e. annual ESTRO-meeting, ICCR).
  • Member of STW-user committee MRI-Linac project, collaboration between UMC Utrecht, Philips and Elekta (2008-2014).
  • Member of NVKF committee for scientific projects in radiotherapy (“Kringdagen”) (2013 - ). Meetings 3x/year; until now 4 meetings in Amsterdam, involving local organization.
  • Co-organizer lectures institute Quantivision (2016 - ).
  • Scientific committee user meetings Brachytherapy Nucletron/Elekta (2010-2014).
  • Scientific committee user meeting Treatment Planning External Beam Elekta (2014).
  • Consultant treatment planning system External beam irradiation (2004-2010), Nucletron B.V. Veenendaal, the Netherlands.
Research programmes

Innovative image guided radiotherapy

Image guidance is essential for high-precision dose delivery in radiotherapy. It comprises the pre-treatment localization of the target with CT and/or MRI as well as safeguarding patient positioning during treatment. Especially the introduction of the linac mounted Cone Beam CT has opened a new realm of possibilities to enhance treatment precision, including:

  • Localization of mobile tumors and organs-at-risk.
  • Improvement of visualization of the relevant anatomy by application of markers in or around the tumor.
  • Bio-mechanical modeling of the internal anatomy.  
  • Strategies for geometrical and dosimetric corrections of the treatment, including adaptive radiotherapy ( ART).

Focus is on mobile gastrointestinal/abdominal tumors (pancreatic, bladder and esophagus).
Moreover, external beam radiotherapy is combined with other techniques:

  • Brachytherapy: the tumor is irradiated locally with a radioactive source
  • Hyperthermia: the effect of irradiation is enhanced by heating.

Research includes modeling and quantification of the synergistic effect of these combinations.

 

 

Faculty
Dr. A. Bel
Dr. T. Alderliesten PhD
Dr. P.A.N. Bosman PhD (Centrum Wiskunde en Informatica (CWI), Amsterdam)
Dr. J. Crezee PhD
Dr. I.W.E.M. van Dijk

Postdocs
Dr. A. van der Horst
Dr. P. Kok

PhD Students
Drs. P. de Boer
Drs. L.E. van Heerden
Drs. S.C. Huijskens
P. Jin MSc
C.M. van Leeuwen MSc
M.C. van der Meer MSc
Drs. E. Versteijne
Z. Wang

Others
Dr. R. van der Laarse (Quality RT BV)

Prof. dr. C.R.N. Rasch (Image guided and physics application in the clinic)

Other research related activities
  • Membership of medical or scientific committee, NVKF, Member scientific committee ("Kring klinische fysica RT")
  • Membership of medical or scientific committee, NVRO, Paediatric oncology
  • Membership of medical or scientific committee, Paediatric Radiation Oncology Society, Peadiatric radiotherapy physics network
  • Consultant, Elekta A.B. Stockholm, Sweden
  • Consultant, Medlogix, Rome, Italy
Current research funding
  • Elekta Ltd.
  • KWF Kankerbestrijding
  • Nijbakker-Morra Stichting
  • NWO
  • Stichting KIKA
  • Universiteit Twente