Who is Who

  • Principal Investigator
  • Male

Prof. dr. T.K. van den Berg

Position: Professor
Main activities: Research
Specialisation: Immunotherapy
foto T.K. van den Berg is one of the AMC Principal Investigators
Focus of research:

Our group at the Phagocyte Laboratory (Sanquin Research) of the Landsteiner Laboratory is interested in antibody immunotherapy against cancer. The major aim is to improve treatment of cancer patients with therapeutic antibodies in order to reduce the need for non-specific agents, such as chemotherapeutics. We have identified CD47-SIRPalpha interactions as an innate immune checkpoint during antibody therapy in cancer. Work is ongoing to explore the mechanisms of antibody-dependent cancer cell destruction by human innate immune cells and the ways in which this can be further improved. We are also interested in the role of innate immune cells in other diseases, including primary immunodeficiencies. In that context the Phagocyte Laboratory also provides a specialized diagnostic service for phagocyte functional and genetic defects.

Please also see our webpage of the laboratory of Blood Cell Research at Sanquin:

http://www.sanquin.nl/en/research/principal-investigators/pi-timo-vanden-berg/

AMC themes: Infection & Immunity, Oncology
Departments: Landsteiner Laboratory
Bruggeman CW, Dekkers G, Bentlage AEH, Treffers LW, Nagelkerke SQ, Lissenberg-Thunnissen S, Koeleman CAM, Wuhrer M, van den Berg TK, Rispens T, Vidarsson G, Kuijpers TW, Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile. J IMMUNOL 2017;199 (1):204-211 [PubMed]
de Boer M, van Leeuwen K, Geissler J, van Alphen F, de Vries E, van der Kuip M, Terheggen SWJ, Janssen H, van den Berg TK, Meijer AB, Roos D, Kuijpers TW, Hermansky-Pudlak syndrome type 2: Aberrant pre-mRNA splicing and mislocalization of granule proteins in neutrophils. HUM MUTAT 2017;38 (10):1402-1411 [PubMed]
Dekkers G, Treffers L, Plomp R, Bentlage AEH, de Boer M, Koeleman CAM, Lissenberg-Thunnissen SN, Visser R, Brouwer M, Mok JY, Matlung H , van den Berg TK, van Esch WJE, Kuijpers TW, Wouters D, Rispens T, Wuhrer M, Vidarsson G, Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities. FRONT IMMUNOL 2017;8:877 [PubMed]
Hiemstra IH, van Hamme JL, Janssen MH, van den Berg TK, Kuijpers TW, Dexamethasone promotes granulocyte mobilization by prolonging the half-life of granulocyte-colony-stimulating factor in healthy donors for granulocyte transfusions. TRANSFUSION 2017;57 (3):674-684 [PubMed]
Klei TRL, Meinderts SM, van den Berg TK, van Bruggen R, From the Cradle to the Grave: The Role of Macrophages in erythropoiesis and erythrophagocytosis. FRONT IMMUNOL 2017;8:73 [PubMed]
Kuijpers TW, Tool ATJ, van der Bijl I, de Boer M, van Houdt M, de Cuyper IM, Roos D, van Alphen F, van Leeuwen K, Cambridge EL, Arends MJ, Dougan G, Clare S, Ramirez-Solis R, Pals ST, Adams DJ, Meijer AB, van den Berg TK, Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency. J ALLERGY CLIN IMMUN 2017;140 (1):273-+ [PubMed]
Matlung HL, Szilagyi K, Barclay NA, van den Berg TK, The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer. IMMUNOL REV 2017;276 (1):145-164 [PubMed]
Meinderts SM, Sins JWR, Fijnvandraat K, Nagelkerke SQ, Geissler J, Tanck MW, Bruggeman C, Biemond BJ, Rijneveld AW, Kerkhoffs JLH, Pakdaman S, Habibi A, van Bruggen R, Kuijpers TW, Pirenne F, van den Berg TK, Non-classical FCGR2C haplotype is associated with protection from red blood cell allo-immunization in sickle cell disease. BLOOD 2017;ahead of print [PubMed]
Nagelkerke SQ. A field guide to human Fc-gamma receptors: Genetics, cellular expression and interaction with immunoglobulins. S.l.: s.n.; 2017. 305p. ISBN 978-94-6299-570-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Sanquin, Landsteiner Laboratory, Department of Blood Cell Research. (Promotor(s): Kuijpers TW; copromotor(s): van den Berg TK)
Treffers LW, Zhao XW, van der Heijden J, Nagelkerke SQ, van Rees DJ, Gonzalez P, Geissler J, Verkuijlen P, van Houdt M, de Boer M, Kuijpers TW, van den Berg TK, Matlung HL, Genetic variation of human neutrophil Fcγ receptors and SIRPα in antibody-dependent cellular cytotoxicity towards cancer cells. EUR J IMMUNOL 2017;ahead of print [PubMed]
van de Geer A, Gazendam RP, Tool ATJ, van Hamme JL, de Korte D, van den Berg TK, Zeerleder SS, Kuijpers TW, Characterization of buffy coat-derived granulocytes for clinical use: a comparison with granulocyte colony-stimulating factor/dexamethasone-pretreated donor-derived products. VOX SANG 2017;112 (2):173-182 [PubMed]
van der Spek AH, Surovtseva OV, Aan S, Tool ATJ, van de Geer A, Demir K, van Gucht ALM, van Trotsenburg ASP, van den Berg TK, Fliers E, Boelen A, Increased circulating interleukin-8 in patients with resistance to thyroid hormone receptor α. ENDOCR CONNECT 2017;6 (8):731-740 [PubMed]
Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P, The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. SCI IMMUNOL 2017;ahead of print [PubMed]
Gazendam RP. Neutrophil microbial killing mechanisms: Lessons learned from primary immunodeficiencies. S.l.: s.n.; 2016. 336p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kuijpers TW; copromotor(s): van den Berg TK, Roos D)
Gazendam RP, van de Geer A, Roos D, van den Berg TK, Kuijpers TW, How neutrophils kill fungi. IMMUNOL REV 2016;273 (1):299-311 [PubMed]
Gazendam RP, van de Geer A, van Hamme JL, Helgers L, Rohr J, Chrabieh M, Picard C, Roos D, van den Berg JM, van den Berg TK, Kuijpers TW, Proinflammatory cytokine response toward fungi but not bacteria in chronic granulomatous disease. J ALLERGY CLIN IMMUN 2016;138 (3):928-+ [PubMed]
Gazendam RP, van de Geer A, van Hamme JL, Tool ATJ, van Rees DJ, Aarts CEM, van den Biggelaar M, van Alphen F, Verkuijlen P, Meijer AB, Janssen H, Roos D, van den Berg TK, Kuijpers TW, Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components. HAEMATOLOGICA 2016;101 (5):587-596 [PubMed]
Gazendam RP, van Hamme JL, Tool ATJ, Hoogenboezem M, van den Berg JM, Prins JM, Vitkov L, van de Veerdonk FL, van den Berg TK, Roos D, Kuijpers TW, Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects. J IMMUNOL 2016;196 (3):1272-1283 [PubMed]
Matlung HL, Szilagyi K, Kuijpers TW, van Lier RAW, van den Berg TK, Immune checkpoint blockade: Which switches to hit and how much?. IMMUNOL LETT 2016;180:73-74 [PubMed]
Meinders M, Hoogenboezem M, Scheenstra MR, de Cuyper IM, Papadopoulos P, Németh T, Mócsai A, van den Berg TK, Kuijpers TW, Gutiérrez L, Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment. PLOS ONE 2016;11 (5):e0154342 [PubMed]
Scheenstra MR, de Cuyper IM, Branco-Madeira F, de Bleser P, Kool M, Meinders M, Hoogenboezem M, Mul E, Wolkers MC, Salerno F, Nota B, Saeys Y, Klarenbeek S, van Ijcken WFJ, Hammad H, Philipsen S, van den Berg TK, Kuijpers TW, Lambrecht BN, Gutiérrez L, GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid. J IMMUNOL 2016;197 (11):4312-4324 [PubMed]
Szilagyi K. Role of inflammation in development of atherosclerosis. S.l.: s.n.; 2016. 191p. Proefschrift Vrije Universiteit Amsterdam, VUmc. (Promotor(s): Kraal G, de Winther MPJ; copromotor(s): van den Berg TK)
Treffers LW, Hiemstra IH, Kuijpers TW, van den Berg TK, Matlung HL, Neutrophils in cancer. IMMUNOL REV 2016;273 (1):312-328 [PubMed]
van Rees DJ, Szilagyi K, Kuijpers TW, Matlung HL, van den Berg TK, Immunoreceptors on neutrophils. SEMIN IMMUNOL 2016;28 (2):94-108 [PubMed]
Alvarez-Zarate J, Matlung HL, Matozaki T, Kuijpers TW, Maridonneau-Parini I, van den Berg TK, Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. PLOS ONE 2015;10 (6):e0127178 [PubMed]
Hoeksema MA, Scicluna BP, Boshuizen MCS, van der Velden S, Neele AE, van den Bossche J, Matlung HL, van den Berg TK, Goossens P, de Winther MPJ, IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment. J IMMUNOL 2015;194 (8):3909-3916 [PubMed]
Kooij G, Braster R, Koning JJ, Laan LC, van Vliet SJ, Los T, Eveleens AM, van der Pol SMA, Förster-Waldl E, Boztug K, Belot A, Szilagyi K, van den Berg TK, van Buul JD, van Egmond M, de Vries HE, Cummings RD, Dijkstra CD, van Die I, Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis. ACTA NEUROPATHOL COM 2015;3 (1):45 [PubMed]
Kostova EB, Beuger BM, Klei TRL, Halonen P, Lieftink C, Beijersbergen R, van den Berg TK, van Bruggen R, Identification of signalling cascades involved in red blood cell shrinkage and vesiculation. BIOSCIENCE REP 2015;35 (2):e00187 [PubMed]
Kostova EB, Beuger BM, Veldthuis M, van der Werff ten Bosch J, Kühnle I, van den Akker E, van den Berg TK, van Zwieten R, van Bruggen R, Intrinsic defects in erythroid cells from familial hemophagocytic lymphohistiocytosis type 5 patients identify a role for STXBP2/Munc18-2 in erythropoiesis and phospholipid scrambling. EXP HEMATOL 2015;43 (12):1072-1076 [PubMed]
Meinders M, Kulu DI, van de Werken HJG, Hoogenboezem M, Janssen H, Brouwer RWW, van Ijcken WFJ, Rijkers EJ, Demmers JAA, Krüger I, van den Berg TK, Suske G, Gutiérrez L, Philipsen S, Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. BLOOD 2015;125 (12):1957-1967 [PubMed]
Nagelkerke SQ, Tacke CE, Breunis WB, Geissler J, Sins JWR, Appelhof B, van den Berg TK, de Boer M, Kuijpers TW, Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression. GENES IMMUN 2015;16 (6):422-429 [PubMed]
Scheenstra MR, Salunkhe V, de Cuyper IM, Hoogenboezem M, Li E, Kuijpers TW, van den Berg TK, Gutiérrez L, Characterization of hematopoietic GATA transcription factor expression in mouse and human dendritic cells. BLOOD CELL MOL DIS 2015;55 (4):293-303 [PubMed]
Szilagyi K, Gazendam RP, van Hamme JL, Tool ATJ, van Houdt M, Vos WAJW, Verkuijlen P, Janssen H, Belot A, Juillard L, Förster-Waldl E, Boztug K, Kraal G, de Winther MPJ, Kuijpers TW, van den Berg TK, Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency. J ALLERGY CLIN IMMUN 2015;136 (5):1404-7.e1-10 [PubMed]
Szilagyi K, Gijbels MJJ, van der Velden S, Heinsbroek SEM, Kraal G, de Winther MPJ, van den Berg TK, Dectin-1 deficiency does not affect atherosclerosis development in mice. ATHEROSCLEROSIS 2015;239 (2):318-321 [PubMed]
van den Berg TK, van Bruggen R, Loss of CD47 Makes Dendritic Cells See Red. IMMUNITY 2015;43 (4):622-624 [PubMed]
Vendelbosch S. Unraveling the genetic expression of the highly variable immune receptors of a killer. S.l.: s.n.; 2015. 158p. ISBN 978-94-6182-575-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Sanquin Research and Landsteiner Laboratory, Amsterdam, Department of Blood Cell Research. (Promotor(s): Kuijpers TW; copromotor(s): van den Berg TK)
Vendelbosch S, de Boer M, van der Heijde D, van den Berg TK, van Gaalen FA, Kuijpers TW, KIR3DL1 and KIR3DL2 gene copy number variation in axial spondyloarthritis. TISSUE ANTIGENS 2015;85 (6):497-498 [PubMed]
Vendelbosch S, de Boer M, van Leeuwen K, Pourfarzad F, Geissler J, van den Berg TK, Kuijpers TW, Novel insights in the genomic organization and hotspots of recombination in the human KIR locus through analysis of intergenic regions. GENES IMMUN 2015;16 (2):103-111 [PubMed]
Vendelbosch S, Heslinga SC, John M, van Leeuwen K, Geissler J, de Boer M, Tanck MWT, van den Berg TK, Crusius JBA, van der Horst-Bruinsma IE, Kuijpers TW, Study on the protective effect of the KIR3DL1 gene in ankylosing spondylitis. ARTHRITIS RHEUMATOL 2015;67 (11):2957-2965 [PubMed]
Alvarez Zarate J. The phagocyte inhibitory receptor sirpα in the immune system. S.l.: s.n.; 2014. 148p. ISBN 9789461824950 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kuijpers TW; copromotor(s): van den Berg TK)
Barclay AN, van den Berg TK, The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target. ANNU REV IMMUNOL 2014;32:25-50 [PubMed]
Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange PE, Saut N, Pillois X, Nurden AT, Cambien F, Pierres A, van den Berg TK, Kuijpers TW, Alessi MC, Tregouet DA, Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding. J EXP MED 2014;211 (7):1349-1362 [PubMed]
de Back DZ, Kostova EB, van Kraaij M, van den Berg TK, van Bruggen R, Of macrophages and red blood cells; a complex love story. FRONT PHYSIOL 2014;5:9 [PubMed]
de Boer M, van Leeuwen K, Geissler J, Weemaes CM, van den Berg TK, Kuijpers TW, Warris A, Roos D, Primary immunodeficiency caused by an exonized retroposed gene copy inserted in the CYBB gene. HUM MUTAT 2014;35 (4):486-496 [PubMed]
Gazendam RP, van Hamme JL, Tool ATJ, van Houdt M, Verkuijlen PJJH, Herbst M, Liese JG, van de Veerdonk FL, Roos D, van den Berg TK, Kuijpers TW, Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects. BLOOD 2014;124 (4):590-597 [PubMed]
Nagelkerke SQ, Aan de Kerk DJ, Jansen MH, van den Berg TK, Kuijpers TW, Failure to detect functional neutrophil B helper cells in the human spleen. PLOS ONE 2014;9 (2):e88377 [PubMed]
Nagelkerke SQ, Dekkers G, Kustiawan I, van de Bovenkamp FS, Geissler J, Plomp R, Wuhrer M, Vidarsson G, Rispens T, van den Berg TK, Kuijpers TW, Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages. BLOOD 2014;124 (25):3709-3718 [PubMed]
Szilagyi K, Meijer AB, Neele AE, Verkuijlen P, Leitges M, Dabernat S, Förster-Waldl E, Boztug K, Belot A, Kuijpers TW, Kraal G, de Winther MPJ, van den Berg TK, PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages. CARDIOVASC RES 2014;104 (3):467-476 [PubMed]
van der Heijden J. Genetic variation in human Fc gamma receptors: Functional consequences of polymorphisms and copy number variation. S.l.: s.n.; 2014. 163p. ISBN 9789461824592 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Sanquin Research, Department of Blood Cell Research. (Promotor(s): Kuijpers TW; copromotor(s): van den Berg TK)
van der Heijden J, Nagelkerke S , Zhao X, Geissler J, Rispens T, van den Berg TK, Kuijpers TW, Haplotypes of FcγRIIa and FcγRIIIb polymorphic variants influence IgG-mediated responses in neutrophils. J IMMUNOL 2014;192 (6):2715-2721 [PubMed]
van de Vijver E, Tool ATJ, Sanal Ö, Çetin M, Ünal S, Aytac S, Seeger K, Pagliara D, Rutella S, van den Berg TK, Kuijpers TW, Kindlin-3-independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III. J ALLERGY CLIN IMMUN 2014;133 (4):1215-1218 [PubMed]
Zhao XW. Targeting CD47-SIRPα interactions for potentiating therapeutic antibody-mediated tumor cell destruction by phagocytes. S.l.: s.n.; 2014. 149p. ISBN 9789462592384 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Sanquin Research and Landsteiner Laboratory AMC, -. (Promotor(s): Kuijpers TW; copromotor(s): van den Berg TK)
Burger P, Kostova E, Bloem E, Hilarius-Stokman P, Meijer AB, van den Berg TK, Verhoeven AJ, de Korte D, van Bruggen R, Potassium leakage primes stored erythrocytes for phosphatidylserine exposure and shedding of pro-coagulant vesicles. BRIT J HAEMATOL 2013;160 (3):377-386 [PubMed]
de Cuyper IM, Meinders M, van de Vijver E, de Korte D, Porcelijn L, de Haas M, Eble JA, Seeger K, Rutella S, Pagliara D, Kuijpers TW, Verhoeven AJ, van den Berg TK, Gutiérrez L, A novel flow cytometry-based platelet aggregation assay. BLOOD 2013;121 (10):E70-E80 [PubMed]
Drewniak A, Gazendam RP, Tool ATJ, van Houdt M, Jansen MH, van Hamme JL, van Leeuwen EMM, Roos D, Scalais E, de Beaufort C, Janssen H, van den Berg TK, Kuijpers TW, Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. BLOOD 2013;121 (13):2385-2392 [PubMed]
Irandoust M, Alvarez Zarate J, Hubeek I, van Beek EM, Schornagel K, Broekhuizen AJF, Akyuz M, van de Loosdrecht AA, Delwel R, Valk PJ, Sonneveld E, Kearns P, Creutzig U, Reinhardt D, de Bont ESJM, Coenen EA, van den Heuvel-Eibrink MM, Zwaan CM, Kaspers GJL, Cloos J, van den Berg TK, Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells. PLOS ONE 2013;8 (1):e52143 [PubMed]
O'Neill ASG, van den Berg TK, Mullen GED, Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation. IMMUNOLOGY 2013;138 (3):198-207 [PubMed]
Samson T, van Buul JD, Kroon J, Welch C, Bakker EN, Matlung HL, van den Berg TK, Sharek L, Doerschuk C, Hahn K, Burridge K, The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. PLOS ONE 2013;8 (1):e55202 [PubMed]
Szilagyi K, van den Berg TK, A role for PKCδ in foam cell formation?. CARDIOVASC RES 2013;97 (2):389 [PubMed]
van der Heijden J, Geissler J, van Mirre E, van Deuren M, van der Meer JWM, Salama A, van den Berg TK, Roos D, Kuijpers TW, A novel splice variant of FcγRIIa: a risk factor for anaphylaxis in patients with hypogammaglobulinemia. J ALLERGY CLIN IMMUN 2013;131 (5):1408-16.e5 [PubMed]
van de Vijver E. Kindlin-3 in hematopoietic integrin activation: absense in leucyte adhesion deficiency type III. s.l.: s.n.; 2013. 155p. ISBN 9789461822888 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kuijpers TW; copromotor(s): van den Berg TK, Roos D)
van de Vijver E, van den Berg TK, Kuijpers TW, Leukocyte adhesion deficiencies. HEMATOL ONCOL CLIN N 2013;27 (1):101-16, viii [PubMed]
Vendelbosch S, de Boer M, Gouw RATW, Ho CKY, Geissler J, Swelsen WTN, Moorhouse MJ, Lardy NM, Roos D, van den Berg TK, Kuijpers TW, Extensive variation in gene copy number at the killer immunoglobulin-like receptor locus in humans. PLOS ONE 2013;8 (6):e67619 [PubMed]
Zhao X, Matlung H , Kuijpers TW, van den Berg TK, On the mechanism and benefit of siRNA-mediated targeting of CD47 in cancer. MOL THER 2013;21 (10):1811-1812 [PubMed]
Zhao XW, Gazendam RP, Drewniak A, van Houdt M, Tool ATJ, van Hamme JL, Kustiawan I, Meijer AB, Janssen H, Russell DG, van de Corput L, Tesselaar K, Boelens JJ, Kuhnle I, van der Werff ten Bosch J, Kuijpers TW, van den Berg TK, Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) syndrome caused by STXBP2/Munc18-2 mutations. BLOOD 2013;122 (1):109-111 [PubMed]
Burger P, de Korte D, van den Berg TK, van Bruggen R, CD47 in Erythrocyte Ageing and Clearance - the Dutch Point of View. TRANSFUS MED HEMOTH 2012;39 (5):348-352 [PubMed]
Burger P, Hilarius-Stokman P, de Korte D, van den Berg TK, van Bruggen R, CD47 functions as a molecular switch for erythrocyte phagocytosis. BLOOD 2012;119 (23):5512-5521 [PubMed]
Kenzel S, Mergen M, von Süßkind-Schwendi J, Wennekamp J, Deshmukh SD, Haeffner M, Triantafyllopoulou A, Fuchs S, Farmand S, Santos-Sierra S, Seufert J, van den Berg TK, Kuijpers TW, Henneke P, Insulin Modulates the Inflammatory Granulocyte Response to Streptococci via Phosphatidylinositol 3-Kinase. J IMMUNOL 2012;189 (9):4582-4591 [PubMed]
van Beek EM, Zarate JA, van Bruggen R, Schornagel K, Tool ATJ, Matozaki T, Kraal G, Roos D, van den Berg TK, SIRP alpha Controls the Activity of the Phagocyte NADPH Oxidase by Restricting the Expression of gp91(phox). CELL REP 2012;2 (4):748-755 [PubMed]
van der Heijden J, Breunis WB, Geissler J, de Boer M, van den Berg TK, Kuijpers TW, Phenotypic Variation in IgG Receptors by Nonclassical FCGR2C Alleles. J IMMUNOL 2012;188 (3):1318-1324 [PubMed]
van de Vijver E, de Cuyper IM, Gerrits AJ, Verhoeven AJ, Seeger K, Gutiérrez L, van den Berg TK, Kuijpers TW, Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin beta 1 and beta 3 in platelet adhesion to collagen. BLOOD 2012;119 (2):583-586 [PubMed]
Zhao XW, Kuijpers TW, van den Berg TK, Is targeting of CD47-SIRP alpha enough for treating hematopoietic malignancy?. BLOOD 2012;119 (18):4333-4334 [PubMed]
Zhao XW, Matlung HL, Kuijpers TW, van den Berg TK, On the mechanism of CD47 targeting in cancer. P NATL ACAD SCI USA 2012;109 (42):E2843-E2843; author reply E2845 [PubMed]
Leito JTD, Ligtenberg AJM, van Houdt M, van den Berg TK, Wouters D, The bacteria binding glycoprotein salivary agglutinin (SAG/gp340) activates complement via the lectin pathway. MOL IMMUNOL 2011;49 (1-2):185-190 [PubMed]
Orelio C, van der Sluis RM, Verkuijlen P, Nethe M, Hordijk PL, van den Berg TK, Kuijpers TW, Altered intracellular localization and mobility of SBDS protein upon mutation in Shwachman-Diamond syndrome. PLOS ONE 2011;6 (6):e20727 [PubMed]
Zhao XW, van Beek EM, Schornagel K, van der Maaden H, van Houdt M, Otten MA, Finetti P, van Egmond M, Matozaki T, Kraal G, Birnbaum D, van Elsas A, Kuijpers TW, Bertucci F, van den Berg TK, CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction. P NATL ACAD SCI USA 2011;108 (45):18342-18347 [PubMed]
Drewniak A, Tool ATJ, Geissler J, van Bruggen R, van den Berg TK, Kuijpers TW, Toll-like receptor-induced reactivity and strongly potentiated IL-8 production in granulocytes mobilized for transfusion purposes. BLOOD 2010;115 (22):4588-4596 [PubMed]
van Bruggen R, Drewniak A, Tool ATJ, Jansen M, van Houdt M, Geissler J, van den Berg TK, Chapel H, Kuijpers TW, Toll-Like Receptor Responses in IRAK-4-Deficient Neutrophils. J INNATE IMMUN 2010;2 (3):280-287 [PubMed]
van Bruggen R, Köker MY, Jansen M, van Houdt M, Roos D, Kuijpers TW, van den Berg TK, Human NLRP3 inflammasome activation is Nox1-4 independent. BLOOD 2010;115 (26):5398-5400 [PubMed]
van den Berg TK, On the origin and function of immune 'self' recognition. IMMUNOL LETT 2010;128 (1):24-25 [PubMed]
Drewniak A, van Raam BJ, Geissler J, Tool ATJ, Mook ORF, van den Berg TK, Baas F, Kuijpers TW, Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes. BLOOD 2009;113 (23):5979-5998 [PubMed]
Fabriek BO, van Bruggen R, Deng DM, Ligtenberg AJM, Nazmi K, Schornagel K, Vloet RPM, Dijkstra CD, van den Berg TK, The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria. BLOOD 2009;113 (4):887-892 [PubMed]
Irandoust M, van den Berg TK, Kaspers GJL, Cloos J, Role of tyrosine phosphatase inhibitors in cancer treatment with emphasis on SH2 domain-containing tyrosine phosphatases (SHPs). ANTI-CANCER AGENT ME 2009;9 (2):212-220 [PubMed]
Kuijpers TW, van de Vijver E, Weterman MAJ, de Boer M, Tool ATJ, van den Berg TK, Moser M, Jakobs ME, Seeger K, Sanal O, Unal S, Cetin M, Roos D, Verhoeven AJ, Baas F, LAD-1/variant syndrome is caused by mutations in FERMT3. BLOOD 2009;113 (19):4740-4746 [PubMed]
Orelio C, Verkuijlen P, Geissler J, van den Berg TK, Kuijpers TW, SBDS expression and localization at the mitotic spindle in human myeloid progenitors. PLOS ONE 2009;4 (9):e7084 [PubMed]
van Beek EM. Signal regulatory protein alpha in phagocyte function. S.l.: s.n.; 2009. 192p. Proefschrift VU, Faculteit Geneeskunde. (Promotor(s): Dijkstra CD, Kraal G; copromotor(s): van den Berg TK)
van Beek EM, de Vries TJ, Mulder L, Schoenmaker T, Hoeben KA, Matozaki T, Langenbach GEJ, Kraal G, Everts V, van den Berg TK, Inhibitory regulation of osteoclast bone resorption by signal regulatory protein alpha. FASEB J 2009;23 (12):4081-4090 [PubMed]
Fabriek BO. Perivascular macrophages in neuroinflammation, the role of the scavenger receptor CD163. S.l.: s.n.; 2008. 207p. Proefschrift VU, Faulteit Geneeskunde. (Promotor(s): Dijkstra CD; copromotor(s): van den Berg TK)
van den Berg TK, van der Schoot CE, Innate immune 'self' recognition: a role for CD47-SIRP alpha interactions in hematopoietic stem cell transplantation. TRENDS IMMUNOL 2008;29 (5):203-206 [PubMed]
van Manen HJ, Verkuijlen P, Wittendorp P, Subramaniam V, van den Berg TK, Roos D, Otto C, Refractive index sensing of green fluorescent proteins in living cells using fluorescence lifetime imaging microscopy. BIOPHYS J 2008;94 (8):L67-L69 [PubMed]
van Raam BJ, Drewniak A, Groenewold V, van den Berg TK, Kuijpers TW, Granulocyte colony-stimulating factor delays neutrophil apoptosis by inhibition of calpains upstream of caspase-3. BLOOD 2008;112 (5):2046-2054 [PubMed]
Fabriek BO, Møller HJ, Vloet RPM, van Winsen LM, Hanemaaijer R, Teunissen CE, Uitdehaag BMJ, van den Berg TK, Dijkstra CD, Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis. J NEUROIMMUNOL 2007;187 (1-2):179-186 [PubMed]
Fabriek BO, Polfliet MMJ, Vloet RPM, van der Schors RC, Ligtenberg AJM, Weaver LK, Geest C, Matsuno K, Moestrup SK, Dijkstra CD, van den Berg TK, The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor. BLOOD 2007;109 (12):5223-5229 [PubMed]
Xu W, Schlagwein N, Roos A, van den Berg TK, Daha MR, van Kooten C, Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages. EUR J IMMUNOL 2007;37 (6):1594-1599 [PubMed]
Zwijnenburg PJG, van der Poll T, Florquin S, Polfliet MMJ, van den Berg TK, Dijkstra CD, Roord JJ, Hack CE, van Furth AM, C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. J INFECT DIS 2007;196 (1):115-123 [PubMed]
Polfliet MMJ, Fabriek BO, Daniëls WP, Dijkstra CD, van den Berg TK, The rat macrophage scavenger receptor CD163: expression, regulation and role in inflammatory mediator production. IMMUNOBIOLOGY 2006;211 (6-8):419-425 [PubMed]
Alblas J, Honing H, de Lavalette CR, Brown MH, Dijkstra CD, van den Berg TK, Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. MOL CELL BIOL 2005;25 (16):7181-7192 [PubMed]
Fabriek BO, Dijkstra CD, van den Berg TK, The macrophage scavenger receptor CD163. IMMUNOBIOLOGY 2005;210 (2-4):153-160 [PubMed]
Fabriek BO, van Haastert ES, Galea I, Polfliet MMJ, Döpp ED, van den Heuvel MM, van den Berg TK, de Groot CJA, van der Valk P, Dijkstra CD, CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation. GLIA 2005;51 (4):297-305 [PubMed]
van Beek EM, Cochrane F, Barclay AN, van den Berg TK, Signal regulatory proteins in the immune system. J IMMUNOL 2005;175 (12):7781-7787 [PubMed]
van den Berg TK, Kraal G, A function for the macrophage F4/80 molecule in tolerance induction. TRENDS IMMUNOL 2005;26 (10):506-509 [PubMed]
van den Berg TK, van Beek EM, Bühring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano Si, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN, A nomenclature for signal regulatory protein family members. J IMMUNOL 2005;175 (12):7788-7789 [PubMed]
van Winsen LLM, Hooper-van Veen T, van Rossum EFC, Polman CH, van den Berg TK, Koper JW, Uitdehaag BMJ, The impact of glucocorticoid receptor gene polymorphisms on glucocorticoid sensitivity is outweighted in patients with multiple sclerosis. J NEUROIMMUNOL 2005;167 (1-2):150-156 [PubMed]
van Winsen LML, Muris DFR, Polman CH, Dijkstra CD, van den Berg TK, Uitdehaag BMJ, Sensitivity to glucocorticoids is decreased in relapsing remitting multiple sclerosis. J CLIN ENDOCR METAB 2005;90 (2):734-740 [PubMed]
Honing H, van den Berg TK, van der Pol SMA, Dijkstra CD, van der Kammen RA, Collard JG, de Vries HE, RhoA activation promotes transendothelial migration of monocytes via ROCK. J LEUKOCYTE BIOL 2004;75 (3):523-528 [PubMed]
van den Berg TK, Honing H, Franke N, van Remoortere A, Schiphorst WECM, Liu FT, Deelder AM, Cummings RD, Hokke CH, van Die I, LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition. J IMMUNOL 2004;173 (3):1902-1907 [PubMed]
van den Berg TK, Yoder JA, Litman GW, On the origins of adaptive immunity: innate immune receptors join the tale. TRENDS IMMUNOL 2004;25 (1):11-16 [PubMed]
Hendriks JJA, de Vries HE, van der Pol SMA, van den Berg TK, van Tol EAF, Dijkstra CD, Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study. BIOCHEM PHARMACOL 2003;65 (5):877-885 [PubMed]
Ledeboer A, Wierinckx A, Bol JGJM, Floris S, Renardel de Lavalette C, de Vries HE, van den Berg TK, Dijkstra CD, Tilders FJH, van Dam AM, Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE. J NEUROIMMUNOL 2003;136 (1-2):94-103 [PubMed]
van Rijn J, van den Berg J, Teerlink T, Kruyt FAE, Schor DSM, Renardel de Lavalette AC, van den Berg TK, Jakobs C, Slotman BJ, Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells. BRIT J CANCER 2003;88 (3):447-454 [PubMed]
Zwijnenburg PJG, Polfliet MMJ, Florquin S, van den Berg TK, Dijkstra CD, van Deventer SJH, Roord JJ, van der Poll T, van Furth AM, CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats. IMMUNOL LETT 2003;85 (1):1-4 [PubMed]
de Vries HE, Hendriks JJA, Honing H, de Lavalette CR, van der Pol SMA, Hooijberg E, Dijkstra CD, van den Berg TK, Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium. J IMMUNOL 2002;168 (11):5832-5839 [PubMed]
Polfliet MMJ, van de Veerdonk F, Döpp EA, van Kesteren-Hendrikx EML, van Rooijen N, Dijkstra CD, van den Berg TK, The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis. J NEUROIMMUNOL 2002;122 (1-2):1-8 [PubMed]
Polfliet MM, Goede PH, van Kesteren-Hendrikx EM, van Rooijen N, Dijkstra CD, van den Berg TK, A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system. J NEUROIMMUNOL 2001;116 (2):188-195 [PubMed]
Polfliet MM, Zwijnenburg PJ, van Furth AM, van der Poll T, Döpp EA, Renardel de Lavalette C, van Kesteren-Hendrikx EM, van Rooijen N, Dijkstra CD, van den Berg TK, Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis. J IMMUNOL 2001;167 (8):4644-4650 [PubMed]
van den Berg TK, Döpp EA, Dijkstra CD, Rat macrophages: membrane glycoproteins in differentiation and function. IMMUNOL REV 2001;184:45-57 [PubMed]
van den Berg TK, Nath D, Ziltener HJ, Vestweber D, Fukuda M, van Die I, Crocker PR, Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J IMMUNOL 2001;166 (6):3637-3640 [PubMed]
van den Berg TK, Puklavec MJ, Barclay AN, Dijkstra CD, Monoclonal antibodies against rat leukocyte surface antigens. IMMUNOL REV 2001;184:109-116 [PubMed]
van den Nieuwenhof IM, Renardel de Lavalette C, Diaz N, van Die I, van den Berg TK, Differential galactosylation of neuronal and haematopoietic signal regulatory protein-alpha determines its cellular binding-specificity. J CELL SCI 2001;114 (Part 7):1321-1329 [PubMed]
Khouw IM, van Wachem PB, van der Worp RJ, van den Berg TK, de Leij LF, van Luyn MJ, Systemic anti-IFN-gamma treatment and role of macrophage subsets in the foreign body reaction to dermal sheep collagen in rats. J BIOMED MATER RES 2000;49 (3):297-304 [PubMed]
Schadee-Eestermans IL, Hoefsmit EC, van de Ende M, Crocker PR, van den Berg TK, Dijkstra CD, Ultrastructural localisation of sialoadhesin (siglec-1) on macrophages in rodent lymphoid tissues. IMMUNOBIOLOGY 2000;202 (4):309-325 [PubMed]
van der Goes A, Hoekstra K, van den Berg TK, Dijkstra CD, Dexamethasone promotes phagocytosis and bacterial killing by human monocytes/macrophages in vitro. J LEUKOCYTE BIOL 2000;67 (6):801-807 [PubMed]
Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Südhof TC, Synaptic assembly of the brain in the absence of neurotransmitter secretion. SCIENCE 2000;287 (5454):864-869 [PubMed]
Jansen J, Uitdehaag B, Koper JW, van den Berg TK, Glucocorticoid receptor ligand binding in monocytic cells using a microplate assay. PATHOBIOLOGY 1999;67 (5-6):262-264 [PubMed]
van den Heuvel MM, Tensen CP, van As JH, van den Berg TK, Fluitsma DM, Dijkstra CD, Döpp EA, Droste A, van Gaalen FA, Sorg C, Högger P, Beelen RH, Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation. J LEUKOCYTE BIOL 1999;66 (5):858-866 [PubMed]
van Die I, Gomord V, Kooyman FN, van den Berg TK, Cummings RD, Vervelde L, Core alpha1-->3-fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep. FEBS LETT 1999;463 (1-2):189-193 [PubMed]
Adams S, van der Laan LJ, Vernon-Wilson E, Renardel de Lavalette C, Döpp EA, Dijkstra CD, Simmons DL, van den Berg TK, Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J IMMUNOL 1998;161 (4):1853-1859 [PubMed]
Crocker PR, Clark EA, Filbin M, Gordon S, Jones Y, Kehrl JH, Kelm S, Le Douarin N, Powell L, Roder J, Schnaar RL, Sgroi DC, Stamenkovic K, Schauer R, Schachner M, van den Berg TK, van der Merwe PA, Watt SM, Varki A, Siglecs: a family of sialic-acid binding lectins. GLYCOBIOLOGY 1998;8 (2):v [PubMed]
Hazenbos WL, Heijnen IA, Meyer D, Hofhuis FM, Renardel de Lavalette CR, Schmidt RE, Capel PJ, van de Winkel JG, Gessner JE, van den Berg TK, Verbeek JS, Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16). J IMMUNOL 1998;161 (6):3026-3032 [PubMed]
van der Goes A, Brouwer J, Hoekstra K, Roos D, van den Berg TK, Dijkstra CD, Reactive oxygen species are required for the phagocytosis of myelin by macrophages. J NEUROIMMUNOL 1998;92 (1-2):67-75 [PubMed]
Veerman EC, Bolscher JG, Appelmelk BJ, Bloemena E, van den Berg TK, Nieuw Amerongen AV, A monoclonal antibody directed against high M(r) salivary mucins recognizes the SO3-3Gal beta 1-3GlcNAc moiety of sulfo-Lewis(a): a histochemical survey of human and rat tissue. GLYCOBIOLOGY 1997;7 (1):37-43 [PubMed]
Kruyt FA, Dijkmans LM, van den Berg TK, Joenje H, Fanconi anemia genes act to suppress a cross-linker-inducible p53-independent apoptosis pathway in lymphoblastoid cell lines. BLOOD 1996;87 (3):938-948 [PubMed]
van den Berg TK, Hasbold J, Renardel de Lavalette C, Döpp EA, Dijkstra CD, Klaus GG, Properties of mouse CD40: differential expression of CD40 epitopes on dendritic cells and epithelial cells. IMMUNOLOGY 1996;88 (2):294-300 [PubMed]
van den Berg TK, van Die I, de Lavalette CR, Döpp EA, Smit LD, van der Meide PH, Tilders FJ, Crocker PR, Dijkstra CD, Regulation of sialoadhesin expression on rat macrophages. Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide. J IMMUNOL 1996;157 (7):3130-3138 [PubMed]
van Rooijen N, Sanders A, van den Berg TK, Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine. J IMMUNOL METHODS 1996;193 (1):93-99 [PubMed]
Biewenga J, van Poppel MN, van den Berg TK, van Rees EP, Sminia T, Reticulum cells in the ontogeny of nasal-associated lymphoid tissue (NALT) in the rat. ADV EXP MED BIOL 1995;371A:407-410 [PubMed]
van den Berg TK, Yoshida K, Dijkstra CD, Mechanism of immune complex trapping by follicular dendritic cells. CURR TOP MICROBIOL 1995;201:49-67 [PubMed]
Yoshida K, Kaji M, Takahashi T, van den Berg TK, Dijkstra CD, Host origin of follicular dendritic cells induced in the spleen of SCID mice after transfer of allogeneic lymphocytes. IMMUNOLOGY 1995;84 (1):117-126 [PubMed]
Barbé E, Döpp EA, Damoiseaux JG, van den Berg TK, Dijkstra CD, The role of macrophages in regeneration of splenic tissue after autologous transplantation in rat. ADV EXP MED BIOL 1994;355:57-61 [PubMed]
Dijkstra CD, Döpp EA, van den Berg TK, Damoiseaux JG, Monoclonal antibodies against rat macrophages. J IMMUNOL METHODS 1994;174 (1-2):21-23 [PubMed]
Kraal G, Hoeben K, Brevé J, van den Berg TK, The role of sialic acid in the localization of lymphocytes in the spleen. IMMUNOBIOLOGY 1994;190 (1-2):138-149 [PubMed]
Yoshida K, van den Berg TK, Dijkstra CD, The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: role of the lymphocytes. EUR J IMMUNOL 1994;24 (2):464-468 [PubMed]
van den Berg TK, van der Ende M, Döpp EA, Kraal G, Dijkstra CD, Localization of beta 1 integrins and their extracellular ligands in human lymphoid tissues. AM J PATHOL 1993;143 (4):1098-1110 [PubMed]
van Poppel MN, van den Berg TK, van Rees EP, Sminia T, Biewenga J, Reticulum cells in the ontogeny of nasal-associated lymphoid tissue (NALT) in the rat. CELL TISSUE RES 1993;273 (3):577-581 [PubMed]
Yoshida K, van den Berg TK, Dijkstra CD, Two different mechanisms of immune-complex trapping in the mouse spleen during immune responses. ADV EXP MED BIOL 1993;329:377-382 [PubMed]
Yoshida K, van den Berg TK, Dijkstra CD, Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcR gamma II-mediated immune-complex trapping. IMMUNOLOGY 1993;80 (1):34-39 [PubMed]
Soesatyo M, van den Berg TK, van Rees EP, Biewenga J, Sminia T, Ontogeny of reticulum cells in the rat intestine and their possible role in the development of the lymphoid microenvironment. REG IMMUNOL 1992;4 (1):46-52 [PubMed]
van den Berg TK, Brevé JJ, Damoiseaux JG, Döpp EA, Kelm S, Crocker PR, Dijkstra CD, Kraal G, Sialoadhesin on macrophages: its identification as a lymphocyte adhesion molecule. J EXP MED 1992;176 (3):647-655 [PubMed]
van den Berg TK, Döpp EA, Daha MR, Kraal G, Dijkstra CD, Selective inhibition of immune complex trapping by follicular dendritic cells with monoclonal antibodies against rat C3. EUR J IMMUNOL 1992;22 (4):957-962 [PubMed]
van Oostveen DC, van den Berg TK, Damoiseaux JG, van Rees EP, Macrophage subpopulations and reticulum cells in rat placenta. An immunohistochemical study. CELL TISSUE RES 1992;268 (3):513-519 [PubMed]
Dijkstra CD, van den Berg TK, The follicular dendritic cell: possible regulatory roles of associated molecules. RES IMMUNOL 1991;142 (3):227-231 [PubMed]
van den Berg TK, Döpp EA, Brevé JJ, Kraal G, Dijkstra CD, The heterogeneity of the reticulum of rat peripheral lymphoid organs identified by monoclonal antibodies. EUR J IMMUNOL 1989;19 (9):1747-1756 [PubMed]
Key publications

Kuijpers TW, Tool ATJ, van der Bijl I, de Boer M, van Houdt M, de Cuyper IM, Roos D, van Alphen F, van Leeuwen K, Cambridge EL, Arends MJ, Dougan G, Clare S, Ramirez-Solis R, Pals ST, Adams DJ, Meijer AB, van den Berg TK, Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency. J ALLERGY CLIN IMMUN 2017;140 (1):273-+ [PubMed]
van den Berg TK, van Bruggen R, Loss of CD47 Makes Dendritic Cells See Red. IMMUNITY 2015;43 (4):622-624 [PubMed]
Szilagyi K, Gazendam RP, van Hamme JL, Tool ATJ, van Houdt M, Vos WAJW, Verkuijlen P, Janssen H, Belot A, Juillard L, Förster-Waldl E, Boztug K, Kraal G, de Winther MPJ, Kuijpers TW, van den Berg TK, Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency. J ALLERGY CLIN IMMUN 2015;136 (5):1404-7.e1-10 [PubMed]
Barclay AN, van den Berg TK, The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target. ANNU REV IMMUNOL 2014;32:25-50 [PubMed]
Zhao XW, van Beek EM, Schornagel K, van der Maaden H, van Houdt M, Otten MA, Finetti P, van Egmond M, Matozaki T, Kraal G, Birnbaum D, van Elsas A, Kuijpers TW, Bertucci F, van den Berg TK, CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction. P NATL ACAD SCI USA 2011;108 (45):18342-18347 [PubMed]


All Publications

Curriculum Vitae

Please see my profile on the Sanquin Website:

http://www.sanquin.nl/en/research/principal-investigators/pi-timo-vanden-berg/
 

Research programmes

Phagocyte Biology

Our group at the Phagocyte Laboratory (Sanquin Research) of the Landsteiner Laboratory is interested in antibody immunotherapy against cancer. The major aim is to improve treatment of cancer patients with therapeutic antibodies in order to reduce the need for non-specific agents, such as chemotherapeutics. We have identified CD47-SIRP interactions as an innate immune checkpoint during antibody therapy in cancer. Work is ongoing to explore the mechanisms of antibody-dependent cancer cell destruction by human innate immune cells and the ways in which this can be further improved. We are also interested in the role of innate immune cells in other diseases, including primary immunodeficiencies. In that context the Phagocyte Laboratory also provides a specialized diagnostic service for phagocyte functional and genetic defects.

Please also see our webpage of the laboratory of Blood Cell Research at Sanquin:

http://www.sanquin.nl/en/research/principal-investigators/pi-timo-vanden-berg/
 

Faculty
Prof. dr. T.K. van den Berg (Sanquin Research)

Postdocs
Drs. ing. H.L. Matlung (Sanquin Research)
Dr. K. Szilagyi

PhD Students
C.W. Bruggeman
Dr. A. van de Geer MD (UvA)
S.M. Meinderts MSc (Doctor)
M.R. Scheenstra
Drs. L.W. Treffers (Sanquin Research)

Others
Ing. M. de Boer (Sanquin Research)
Ing. J. Geissler (Sanquin Research)
Ing. M. van Houdt (Sanquin Research)
K. van Leeuwen (Sanquin Research)
Ing. K. Schornagel (Sanquin Research)
Dr. A.T.J. Tool (Sanquin Research)
Ing. P. Verkuijlen (Sanquin Resaerch)

Other research related activities
  • None reported
Current research funding
  • None reported