Healthcare evaluation in Obstetrics and Gynecology
For over half of all medical treatments there is no scientific evidence that supports their routine use in clinical care. Within the department of Obstetrics and Gynecology we routinely perform clinical trials that aim to establish the benefit of specific medical treatments as well as diagnostic tests. Results of these trials are integrated into clinical protocols so that we achieve the best possible treatment for our patients. These trials are conducted in the context of a national network of collaborating hospitals under the guidance of the NVOG.
Restoring fertility in childhood cancer patients
In the Netherlands, childhood cancer affects over 400 new children per year. Today, cancer treatments are highly effective, curing over 75% of children with cancer. At the same time, many male childhood cancer survivors are now facing the side effects of cancer treatment of which infertility is an important one. In contrast to adult men with cancer for whom cryopreservation of sperm before onset of chemotherapy is an established and often used method to preserve fertility, there is currently no option to preserve reproductive potential in young boys with cancer. The Center for Reproductive Medicine conducts preclinical research to develop a new method to restore reproductive potential in male childhood cancer survivors by using spermatogonial stem cell transplantation.
Pregnancy is not always without complications and approximately 8% of all pregnancies result in preterm birth (before 37 weeks of gestation) of which 1/5th is born before 32 weeks of gestation. At the same time numerous interventions are conducted just before and during pregnancy as well as during the neonatal period that potentially have consequences for health later in life. The follow me program aims to establish structured and continuous outcome monitoring of the development of these children.