• Principal Investigator
  • Male

Prof. dr. U.H.W. Beuers

Position: Professor
Main activities: Patient care, Research
Specialisation: Gastroenterology and Hepatology
foto U.H.W. Beuers is one of the AMC Principal Investigators
Focus of research:

Pathogenetic and therapeutic aspects of chronic cholestatic liver diseases

The pathophysiology of chronic cholestatic and autoimmune liver diseases like primary biliary cirrhosis, primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes, IgG4-associated cholangitis and various genetic cholestatic disorders is still only partly understood. Although evidence-based therapies are now available for some of these diseases such as primary biliary cirrhosis and autoimmune hepatitis, many more efforts are needed to disclose the pathophysiological mechanisms leading to these diseases and their progression as well as the symptoms like pruritus and fatique from which the majority of affected patients suffer. Using the full spectrum of laboratory techniques, ranging from basic biochemistry and in vitro cell biology to mouse models and translational studies, we try to gain more insight in the pathophysiology of, and possible novel therapeutic approaches towards cholestatic and autoimmune liver diseases.

AMC themes: Metabolic disorders and gastrointestinal diseases
Departments: Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research
Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J, Eksteen B, Ellinghaus D, Färkkilä M, Festen EAM, Floreani A, Franceschet I, Gotthardt DN, Hirschfield GM, van Hoek B, Holm K, Hohenester S, Hov JR, Imhann F, Invernizzi P, Juran BD, Lenzen H, Lieb W, Liu JZ, Marschall HU, Marzioni M, Melum E, Milkiewicz P, Müller T, Pares A, Rupp C, Rust C, Sandford RN, Schramm C, Schreiber S, Schrumpf E, Silverberg MS, Srivastava B, Sterneck M, Teufel A, Vallier L, Verheij J, Vila AV, de Vries B, Zachou K, Chapman RW, Manns MP, Pinzani M, Rushbrook SM, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weersma RK, Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. GUT 2017;-:- [PubMed]
Bolier AR. The role of autotaxin in cholestatic pruritus. S.l.: s.n.; 2017. 178p. ISBN 9789461827975 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Oude Elferink RPJ, Beuers UHW; copromotor(s): Bosma PJ)
Bolier R , de Vries ES, Parés A, Helder J, Kemper EM, Zwinderman K, Oude Elferink RP, Beuers U [Contributors: van Buuren HR, Drenth JP, van Erpecum KJ, van Hoek B, Jansen PLM, van Nieuwkerk KM, de Vree JM]] , Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial. TRIALS 2017;18 (1):230 [PubMed]
Chang JC, Beuers U, Oude Elferink RPJ, The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis. DIGEST DIS 2017;35 (3):217-223 [PubMed]
Chang JC, Go S, Verhoeven AJ, Beuers U, Oude Elferink RPJ, Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis. BBA-BIOENERGETICS 2017;ahead of print [PubMed]
de Niet A, Jansen L, Stelma F, Willemse SB , Kuiken SD, Weijer S, van Nieuwkerk CMJ, Zaaijer HL, Molenkamp R, Takkenberg RB, Koot M, Verheij J, Beuers U, Reesink HW, Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial. LANCET GASTROENTEROL HEPATOL 2017;2 (8):576-584 [PubMed]
de Vries E, Beuers U, Management of cholestatic disease in 2017. LIVER INT 2017;37 (Suppl. 1):123-129 [PubMed]
de Vries EMG, de Krijger M, Färkkilä M, Arola J, Schirmacher P, Gotthardt D, Goeppert B, Trivedi PJ, Hirschfield GM, Ytting H, Vainer B, Buuren HRv, Biermann K, Harms MH, Chazouilleres O, Wendum D, Kemgang AD, Chapman RW, Wang LM, Williamson KD, Gouw ASH, Paradis V, Sempoux C, Beuers U, Hübscher SG, Verheij J, Ponsioen CY, Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study. HEPATOLOGY 2017;65 (3):907-919 [PubMed]
de Vries EMG, Färkkilä M, Milkiewicz P, Hov JR, Eksteen B, Thorburn D, Chazouillères O, Pares A, Nygård S, Gilja OH, Wunsch E, Invernizzi P, Carbone M, Bernuzzi F, Boberg KM, Røsjø H, Rosenberg W, Beuers UH, Ponsioen CY, Karlsen TH, Vesterhus M, Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. LIVER INT 2017;37 (10):1554-1561 [PubMed]
de Vries EM, Wang J, Williamson KD, Leeflang MM, Boonstra K, Weersma RK, Beuers U, Chapman RW, Geskus RB, Ponsioen CY, A novel prognostic model for transplant-free survival in primary sclerosing cholangitis. GUT 2017;ahead of print [PubMed]
Donkers JM, Zehnder B, van Westen GJP, Kwakkenbos MJ, IJzerman AP, Oude Elferink RPJ, Beuers U, Urban S, van de Graaf SFJ, Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP. SCI REP-UK 2017;7 (1):15307 [PubMed]
Doorenspleet ME. Standing out of the crowd: Adaptive immune cells in the pathogenesis and prediction of rheumatoid arthritis and IgG4-related disease. S.l.: s.n.; 2017. 194p. ISBN 9789462336278 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Tak PP, Baas F; copromotor(s): de Vries N, Beuers UHW)
Erice O, Munoz-Garrido P, Vaquero J, Perugorria MJ, Fernandez-Barrena MG, Saez E, Santos-Laso A, Arbelaiz A, Jimenez-Agüero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Ananthanarayanan M, Marzioni M, Prieto J, Beuers U, Oude Elferink RP, LaRusso NF, Bujanda L, Marin JJG, Banales JM, MiRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation. HEPATOLOGY 2017;ahead of print [PubMed]
Hegade VS, Kendrick SFW, Dobbins RL, Miller SR, Thompson D, Richards D, Storey J, Dukes GE, Corrigan M, Oude Elferink RPJ, Beuers U, Hirschfield GM, Jones DE, Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study. LANCET 2017;389 (10074):1114-1123 [PubMed]
Hohenester S, Beuers U, Chronic cholestatic liver diseases. Differential diagnosis, pathogenesis and current treatment in adults. INTERNIST 2017;58 (8):805-825 [PubMed]
Hubers LM, Beuers U, IgG4-related disease of the biliary tract and pancreas: clinical and experimental advances. CURR OPIN GASTROEN 2017;33 (4):310-314 [PubMed]
Hubers LM, Vos H, Schuurman AR, Erken R, Oude Elferink RP, Burgering B, van de Graaf SFJ, Beuers U, Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease. GUT 2017;ahead of print [PubMed]
Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L, Melum E, Kumasaka N, Atkinson EJ, Schlicht EM, Liu JZ, Shah T, Gutierrez-Achury J, Boberg KM, Bergquist A, Vermeire S, Eksteen B, Durie PR, Farkkila M, Müller T, Schramm C, Sterneck M, Weismüller TJ, Gotthardt DN, Ellinghaus D, Braun F, Teufel A, Laudes M, Lieb W, Jacobs G, Beuers U, Weersma RK, Wijmenga C, Marschall HU, Milkiewicz P, Pares A, Kontula K, Chazouillères O, Invernizzi P, Goode E, Spiess K, Moore C, Sambrook J, Ouwehand WH, Roberts DJ, Danesh J, Floreani A, Gulamhusein AF, Eaton JE, Schreiber S, Coltescu C, Bowlus CL, Luketic VA, Odin JA, Chopra KB, Kowdley KV, Chalasani N, Manns MP, Srivastava B, Mells G, Sandford RN, Alexander G, Gaffney DJ, Chapman RW, Hirschfield GM, de Andrade M, Rushbrook SM, Franke A, Karlsen TH, Lazaridis KN, Anderson CA, Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. NAT GENET 2017;49 (2):269-273 [PubMed]
Maroni L, Hohenester SD, van de Graaf SFJ, Tolenaars D, van Lienden K, Verheij J, Marzioni M, Karlsen TH, Oude Elferink RPJ, Beuers U, Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice. HEPATOLOGY 2017;66 (2):542-554 [PubMed]
Runge JH, Smits LP, Verheij J, Depla A, Kuiken SD, Baak BC, Nederveen AJ, Beuers U, Stoker J, MR Spectroscopy-derived Proton Density Fat Fraction Is Superior to Controlled Attenuation Parameter for Detecting and Grading Hepatic Steatosis. RADIOLOGY 2017;ahead of print [PubMed]
Sideras K, Biermann K, Verheij J, Takkenberg BR, Mancham S, Hansen BE, Schutz HM, de Man RA, Sprengers D, Buschow SI, Verseput MCM, Boor PPC, Pan Q, van Gulik TM, Terkivatan T, Ijzermans JNM, Beuers UHW, Sleijfer S, Bruno MJ, Kwekkeboom J, PD-L1, Galectin-9 and CD8(+) tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma. ONCOIMMUNOLOGY 2017;6 (2):e1273309 [PubMed]
Slijepcevic D, Roscam Abbing RLP, Katafuchi T, Blank A, Donkers JM, van Hoppe S, de Waart DR, Tolenaars D, van der Meer JHM, Wildenberg M, Beuers U, Oude Elferink RPJ, Schinkel AH, van de Graaf SFJ, Hepatic Uptake of Conjugated Bile Acids Is Mediated by Both Sodium Taurocholate Cotransporting Polypeptide and Organic Anion Transporting Polypeptides and Modulated by Intestinal Sensing of Plasma Bile Acid Levels in Mice. HEPATOLOGY 2017;66 (5):1631-1643 [PubMed]
Stelma F. Immune responses in hepatitis B and C virus infection. S.l.: s.n.; 2017. 286p. ISBN 978-94-6182-834-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW, Geijtenbeek TBH; copromotor(s): Reesink HW, Kootstra NA)
Trampert DC, Hubers LM, van de Graaf SFJ, Beuers U, On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease. BBA-BIOENERGETICS 2017;ahead of print [PubMed]
van der Ree MH. MicroRNA's in chronic hepatitis B and C virus infection. S.l.: s.n.; 2017. 235p. ISBN 9789461827944 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW; copromotor(s): Reesink HW, Kootstra NA)
van der Ree MH, de Vree JM, Stelma F, Willemse S, van der Valk M, Rietdijk S, Molenkamp R, Schinkel J, van Nuenen AC, Beuers U, Hadi S, Harbers M, van der Veer E, Liu K, Grundy J, Patick AK, Pavlicek A, Blem J, Huang M, Grint P, Neben S, Gibson NW, Kootstra NA, Reesink HW, Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial. LANCET 2017;389 (10070):709-717 [PubMed]
van Dijk R, Aronson SJ, de Waart DR, van de Graaf SF, Duijst S, Seppen J, Oude Elferink R, Beuers U, Bosma PJ, Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo. SCI REP-UK 2017;7 (1):1646 [PubMed]
Weismuller TJ, Trivedi PJ, Bergquist A, Imam M, Lenzen H, Ponsioen CY, Holm K, Gotthardt D, Farkkila MA, Marschall HU, Thorburn D, Weersma RK, Fevery J, Mueller T, Chazouilleres O, Schulze K, Lazaridis KN, Almer S, Pereira SP, Levy C, Mason A, Naess S, Bowlus CL, Floreani A, Halilbasic E, Yimam KK, Milkiewicz P, Beuers U, Huynh DK, Pares A, Manser CN, Dalekos GN, Eksteen B, Invernizzi P, Berg CP, Kirchner GI, Sarrazin C, Zimmer V, Fabris L, Braun F, Marzioni M, Juran BD, Said K, Rupp C, Jokelainen K, Benito de Valle M, Saffioti F, Cheung A, Trauner M, Schramm C, Chapman RW, Karlsen TH, Schrumpf E, Strassburg CP, Manns MP, Lindor KD, Hirschfield GM, Hansen BE, Boberg KM, Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis. GASTROENTEROLOGY 2017;152 (8):1975-1984.e8 [PubMed]
Zweers SJ, de Vries EM, Lenicek M, Tolenaars D, de Waart DR, Koelfat KVK, Groen AK, Olde Damink SWM, Beuers U, Ponsioen C, Jansen PLM, Schaap FG, Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge. HEPATOL INT 2017;11 (1):132-140 [PubMed]
Zweers SJLB. Fibroblast growth factor 19 and interleukin-8 in primary sclerosing cholangitis: New insights sprouting from the inflamed biliary tree. S.l.: s.n.; 2017. 157p. ISBN 9789461827791 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW; copromotor(s): Jansen PLM, Schaap FG)
[Contributors: Hirschfield GM, Beuers U, Corpechot C, Invernizzi P, Jones D, Marzioni M, Schramm C]] , EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. J HEPATOL 2017;67 (1):145-172 [PubMed]
[Contributors: Strassburg CP, Beckebaum S, Geier A, Gotthardt D, Klein R, Melter M, Schott E, Spengler U, Tacke F, Trauner M, Weiler-Normann C, Weismüller TJ, Tannapfel A, Tischendorf JJ, Schramm C, Albert J, Allescher HD, Antoni C, Berg C, Bufler P, Dannel F, Dietrich C, Engelmann G, Feist E, Fickert P, Fischer L, Flechtenmacher C, Friedrich-Rust M, Giek A, Görtz RS, Herzer K, Hofer H, Hohenester S, Höhn M, Hüppe D, In der Smitten S, Jahnel J, Keitel-Anselmino V, Kirchner G, Kremer A , Lauenstein A, Lenzen H, Mayerle J, Müller T, Müllhaupt B, Nashan B, Rust C, Schattenberg JM, Schmidt H, Schreyer A, Sebode M, Siegmund B, Terjung B, Teufel A, van Thiel I, Wirth S, Witte T, Beuers U, Gerken G, Graziadei I, Lohse A, Manns MP, Tilg H]] , S2k Leitlinie Autoimmune Lebererkrankungen. Z GASTROENTEROL 2017;55 (11):1135-1226 [PubMed]
Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lövgren-Sandblom A, Bolier R , Tolenaars D, Kremer AE, Syngelaki A, Noori M, Williams D, Marin JJG, Monte MJ, Nicolaides KH, Beuers U, Oude-Elferink R, Seed PT, Chappell L, Marschall HU, Bunnett NW, Williamson C, Prognostic and Mechanistic Potential of Progesterone Sulfates in Intrahepatic Cholestasis of Pregnancy and Pruritus Gravidarum. HEPATOLOGY 2016;63 (4):1287-1298 [PubMed]
Bolier R , Tolenaars D, Kremer AE, Saris J, Parés A, Verheij J, Bosma PJ, Beuers U, Oude Elferink RPJ, Enteroendocrine cells are a potential source of serum autotaxin in men. BBA-MOL BASIS DIS 2016;1862 (4):696-704 [PubMed]
Boonstra K, de Vries EMG, van Geloven N, van Erpecum KJ, Spanier M, Poen AC, van Nieuwkerk CM, Witteman BJ, Tuynman HA, Naber AH, Kingma PJ, Beuers U, Ponsioen CY [Contributors: Abilakh Missier ET, Baak LC, van Bentem N, van den Brande JM, Brink MA, Bruins Slot W, Cahen DL, Claessen MM, Depla AC, de Groot G, van den Hazel SJ, Klompmaker IJ, Korkmaz KS, Kuyvenhoven JP, Ledeboer M, Loffeld BC, Loffeld RJ, Telleman H, Oosting PR, Riemens SC, Schmidt Böhmer J, Scholten P, Stadhouders PH, Tan G, Teunen A, Thijs JC, Verhagen MA, Viergever PP, Vrij AA, Weinhardt O, Witteman EM]] , Risk factors for primary sclerosing cholangitis. LIVER INT 2016;36 (1):84-91 [PubMed]
Chang JC, Go S, de Waart DR, Munoz-Garrido P, Beuers U, Paulusma CC, Oude Elferink R, Soluble Adenylyl Cyclase Regulates Bile Salt-Induced Apoptosis in Human Cholangiocytes. HEPATOLOGY 2016;64 (2):522-534 [PubMed]
D'Agnolo HMA, Kievit W, Takkenberg RB, Riaño I, Bujanda L, Neijenhuis MK, Brunenberg EJL, Beuers U, Banales JM, Drenth JPH, Ursodeoxycholic acid in advanced polycystic liver disease: A phase 2 multicenter randomized controlled trial. J HEPATOL 2016;65 (3):601-607 [PubMed]
de Niet A. New treatment strategies for chronic hepatitis B: Viral, genetic and immunological factors predicting treatment outcome. S.l.: s.n.; 2016. 290p. ISBN 978-94-6259-998-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW, Zaaijer HL; copromotor(s): Reesink HW, van Leeuwen EMM)
de Vries EMG. Biomarkers for disease progression in primary sclerosing cholangitis. S.l.: s.n.; 2016. 235p. ISBN 978-94-028-0380-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW; copromotor(s): Ponsioen CY)
de Vries EMG, Wang J, Leeflang MMG, Boonstra K, Weersma RK, Beuers UH, Geskus RB, Ponsioen CY, Alkaline phosphatase at diagnosis of primary sclerosing cholangitis and 1 year later: evaluation of prognostic value. LIVER INT 2016;36 (12):1867-1875 [PubMed]
Doorenspleet ME, Hubers LM, Culver EL, Maillette de Buy Wenniger LJ, Klarenbeek PL, Chapman RW, Baas F, van de Graaf SF, Verheij J, van Gulik TM, Barnes E, Beuers U, de Vries N, Immunoglobulin G4(+) B-cell receptor clones distinguish immunoglobulin G 4-related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies. HEPATOLOGY 2016;64 (2):501-507 [PubMed]
Guth C, Beuers U, BECKH K, Eine 22-jährige Mutter mit starkem Juckreiz und zunehmendem Ikterus zwei Wochen nach Beginn der hormonalen Kontrazeption. Z GASTROENTEROL 2016;54 (9):1076-1080 [PubMed]
Hegade VS, Bolier R , Oude Elferink RPJ, Beuers U, Kendrick S, Jones DEJ, A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis. FRONTLINE GASTROENTEROL 2016;7 (3):158-166 [PubMed]
Hoogeveen RM, van der Bom T, de Boer HH, Thurlings RM, Wind BS, Bhagwandin S, de Vries HJC, van Lent AU, Beuers U, van der Wal AC, Nellen FJ, Fatale myocarditis ten gevolge van dapsongebruik bij een patiente behandeld voor lepra.. NED TIJDSCHR DERMATOL VENEREOL 2016;26 (5):277-279
Hoogeveen RM, van der Bom T, de Boer HH, Thurlings RM, Wind BS, de Vries HJC, van Lent AU, Beuers U, van der Wal AC, Nellen FJ, A lethal case of the dapsone hypersensitivity syndrome involving the myocardium. NETH J MED 2016;74 (2):89-92 [PubMed]
Jakulj L, van Dijk TH, de Boer JF, Kootte RS, Schonewille M, Paalvast Y, Boer T, Bloks VW, Boverhof R, Nieuwdorp M, Beuers UHW, Stroes ESG, Groen AK, Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion. CELL METAB 2016;24 (6):783-794 [PubMed]
Jansen L. Virus-host interplay in chronic hepatitis B: Predicting response to immunomodulating antiviral therapy. S.l.: s.n.; 2016. 187p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW, Zaaijer HL; copromotor(s): Reesink HW, Kootstra NA)
Koot BGP, Alders M, Verheij J, Beuers U, Cobben JM, A de novo mutation in KCNN3 associated with autosomal dominant idiopathic non-cirrhotic portal hypertension. J HEPATOL 2016;64 (4):974-977 [PubMed]
Kremer AE, Gonzales E, Schaap FG, Oude Elferink RPJ, Jacquemin E, Beuers U, Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders. J PEDIATR GASTR NUTR 2016;62 (4):530-535 [PubMed]
Lionarons DA, Heger M, van Golen RF, Alles LK, van der Mark VA, Kloek JJ, de Waart DR, Marsman HA, Rusch H, Verheij J, Beuers U, Paulusma CC, van Gulik TM, Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport. SCI REP-UK 2016;6:31829 [PubMed]
Nevens F, Andreone P, Mazzella G, Strasser SI, Bowlus C, Invernizzi P, Drenth JPH, Pockros PJ, Regula J, Beuers U, Trauner M, Jones DE, Floreani A, Hohenester S, Luketic V, Shiffman M, van Erpecum KJ, Vargas V, Vincent C, Hirschfield GM, Shah H, Hansen B, Lindor KD, Marschall HU, Kowdley KV, Hooshmand-Rad R, Marmon T, Sheeron S, Pencek R, MacConell L, Pruzanski M, Shapiro D [Contributors: Angus P, Roberts S, Strasser SI, Trauner M, Vogel W, Graziadei I, Nevens F, Shah H, Vincent C, de Lédinghen V, Berg T, Gotthardt D, Hartmann H, Hohenester SD, Kremer AE, Lammert F, Manns MP, Rust C, Schramm C, Trautwein C, Zeuzem S, Andreone P, Floreani A, Invernizzi P, Carbone M, Mazzella G, Beuers U, Drenth JPH, Hansen B, van Erpecum KJ, van Nieuwkerk CCMJ, Celinski K, Gonciarz M, Hartleb M, Milkiewicz P, Regula J, Parés A, Vargas V, Marschall HU, Bramley P, Thorburn D, Mookerjee RP, Burroughs A, Chapman R, Dillon JF, Greer JA, Hirschfield GM, Tripathi D, Jones DE, McCune A, Ryder S, Bacon BR, Naik J, Wang LS, Bodenheimer HC, Bowlus CL, Chalasani N, Forman LM, Gordon SC, Kowdley KV, Lindor KD, Luketic VA, Mayo M, Muir AJ, Pockros PJ, Reddy KG, Shiffman M, Talwalker JT, Vierling JM]] , A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis. NEW ENGL J MED 2016;375 (7):631-643 [PubMed]
Runge JH, Akkerman EM, Troelstra MA, Nederveen AJ, Beuers U, Stoker J, Comparison of clinical MRI liver iron content measurements using signal intensity ratios, R 2 and R 2. ABDOM RADIOL 2016;41 (11):2123-2131 [PubMed]
Smits LP, Coolen BF, Panno MD, Runge JH, Nijhof WH, Verheij J, Nieuwdorp M, Stoker J, Beuers UH, Nederveen AJ, Stroes ES, Noninvasive Differentiation between Hepatic Steatosis and Steatohepatitis with MR Imaging Enhanced with USPIOs in Patients with Nonalcoholic Fatty Liver Disease: A Proof-of-Concept Study. RADIOLOGY 2016;278 (3):782-791 [PubMed]
van Gerven NMF, van der Eijk AA, Pas SD, Zaaijer HL, de Boer YS, Witte BI, van Nieuwkerk CMJ, Mulder CJJ, Bouma G, de Man RA [Contributors: Drenth J, den Ouden J, Verdonk R, Vrolijk J, Koek G, Brouwer J, Baak L, van Hoek B, Baven-Pronk A, Coenraad M, van Erpecum K, Beuers U, Klempt-Kropp M, van Meyel J, Linskens R, Spanier B, Kneppelhout J, Kuyvenhoven J, van Geenen E, Wagtmans M, Cahen D, Wolfhagen F, Kingma P, de Vree J, Loffeld R, van Buuren H, Friederich P, Schreuder T, van Milligen de Wit A, Alleman M, Bhalla A, Stadhouders P, Verhagen M, Copra C, Pronk M]] , Seroprevalence of Hepatitis E Virus in Autoimmune Hepatitis Patients in the Netherlands. J GASTROINTEST LIVER 2016;25 (1):9-13 [PubMed]
Zweers SJ, Shiryaev A, Komuta M, Vesterhus M, Hov JR, Perugorria MJ, de Waart DR, Chang JC, Tol S, te Velde AA, de Jonge WJ, Banales JM, Roskams T, Beuers U, Karlsen TH, Jansen PL, Schaap FG, Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. LIVER INT 2016;36 (9):1370-1377 [PubMed]
Aronson SJ, Beuers U, Bosma PJ, Progress and challenges in gene therapy for Crigler-Najjar syndrome. EXPERT OPIN ORPHAN D 2015;3 (12):1387-1396
Beuers U, Gershwin ME, Unmet challenges in immune-mediated hepatobiliary diseases. CLIN REV ALLERG IMMU 2015;48 (2-3):127-131 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'. GASTROENTEROLOGY 2015;149 (6):1627-1629 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'. DIGEST LIVER DIS 2015;47 (11):924-926 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing nomenclature for PBC: From "cirrhosis' to "cholangitis'. HEPATOLOGY 2015;62 (5):1620-1622 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'. J HEPATOL 2015;63 (5):1285-1287 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'. CLIN GASTROENTEROL H 2015;13 (11):1867-1869 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'. AM J GASTROENTEROL 2015;110 (11):1536-1538 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'. GUT 2015;64 (11):1671-1672 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'. CLIN RES HEPATOL GAS 2015;39 (5):e57-e59 [PubMed]
Beuers U, Hubers LM, Doorenspleet M, Maillette de Buy Wenniger L, Klarenbeek PL, Boonstra K, Ponsioen C, Rauws E, de Vries N, IgG4-Associated Cholangitis--A Mimic of PSC. DIGEST DIS 2015;33 (Suppl. 2):176-180 [PubMed]
Beuers U, Trauner M, Jansen P, Poupon R, New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond. J HEPATOL 2015;62 (1 Suppl):S25-S37 [PubMed]
Buijs J, Cahen DL, van Heerde MJ, Rauws EA, de Buy Wenniger LJM, Hansen BE, Biermann K, Verheij J, Vleggaar FP, Brink MA, Beuers UHW, van Buuren HR, Bruno MJ, The Long-Term Impact of Autoimmune Pancreatitis on Pancreatic Function, Quality of Life, and Life Expectancy. PANCREAS 2015;44 (7):1065-1071 [PubMed]
de Vries EMG, Beuers U, Ponsioen CY, Biomarkers for disease progression of primary sclerosing cholangitis. CURR OPIN GASTROEN 2015;31 (3):239-246 [PubMed]
de Vries EMG, Verheij J, Hubscher SG, Leeflang MMG, Boonstra K, Beuers U, Ponsioen CY, Applicability and prognostic value of histologic scoring systems in primary sclerosing cholangitis. J HEPATOL 2015;63 (5):1212-1219 [PubMed]
Dyson JK, Hirschfield GM, Adams DH, Beuers U, Mann DA, Lindor KD, Jones DEJ, Novel therapeutic targets in primary biliary cirrhosis. NAT REV GASTRO HEPAT 2015;12 (3):147-158 [PubMed]
Dyson JK, Webb G, Hirschfield GM, Lohse A, Beuers U, Lindor K, Jones DEJ, Unmet clinical need in autoimmune liver diseases. J HEPATOL 2015;62 (1):208-218 [PubMed]
Elferink RO, Bolier R , Kremer AE, Beuers U, Reply. HEPATOLOGY 2015;61 (6):2115 [PubMed]
Ginès P, Beuers U, Cortez-Pinto H, Angsar L, Parès A, Official Congress Report Autoimmune Diseases of the Liver Falk Symposium 197 Lisbon, May 8-9, 2015 Preface. DIGEST DIS 2015;33 (2):1 [PubMed]
Hubers LM, Beuers U, How to Diagnose Immunoglobulin G4-Associated Cholangitis: The Jack-of-All-Trades in the Biliary Tract. VISZERALMEDIZIN 2015;31 (3):185-188 [PubMed]
Hubers LM, Maillette de Buy Wenniger LJ, Doorenspleet ME, Klarenbeek PL, Verheij J, Rauws EA, van Gulik TM, Oude Elferink RPJ, van de Graaf SFJ, de Vries N, Beuers U, IgG4-associated cholangitis: a comprehensive review. CLIN REV ALLERG IMMU 2015;48 (2-3):198-206 [PubMed]
Kremer AE. Molecular mechanisms of pruritus in cholestasis. S.l.: s.n.; 2015. 267p. ISBN 978-94-6259-811-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Oude Elferink RPJ, Beuers UHW; copromotor(s): )
Kremer AE, Bolier R , Dixon PH, Geenes V, Chambers J, Tolenaars D, Ris-Stalpers C, Kaess BM, Rust C, van der Post JA, Williamson C, Beuers U, Oude Elferink RPJ, Autotaxin activity has a high accuracy to diagnose intrahepatic cholestasis of pregnancy. J HEPATOL 2015;62 (4):897-904 [PubMed]
Kremer AE, Namer B, Bolier R , Fischer MJ, Oude Elferink RP, Beuers U, Pathogenesis and Management of Pruritus in PBC and PSC. DIGEST DIS 2015;33 (Suppl. 2):164-175 [PubMed]
Maillette de Buy Wenniger LJ. The biliary tree in health and immune-mediated disease. S.l.: s.n.; 2015. 243p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW, Oude Elferink RPJ; copromotor(s): de Vries N)
Maillette de Buy Wenniger LJ, Beuers U, Immunoglobulin G4-related cholangiopathy: clinical and experimental insights. CURR OPIN GASTROEN 2015;31 (3):252-257 [PubMed]
Maillette de Buy Wenniger LJ, Hohenester S, Maroni L, van Vliet SJ, Oude Elferink RP, Beuers U, The Cholangiocyte Glycocalyx Stabilizes the 'Biliary HCO3 Umbrella': An Integrated Line of Defense against Toxic Bile Acids. DIGEST DIS 2015;33 (3):397-407 [PubMed]
Maroni L, van de Graaf SFJ, Hohenester SD, Oude Elferink RPJ, Beuers U, Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review. CLIN REV ALLERG IMMU 2015;48 (2-3):182-191 [PubMed]
Munoz-Garrido P, Marin JJG, Perugorria MJ, Urribarri AD, Erice O, Sáez E, Úriz M, Sarvide S, Portu A, Concepcion AR, Romero MR, Monte MJ, Santos-Laso Á, Hijona E, Jimenez-Agüero R, Marzioni M, Beuers U, Masyuk TV, LaRusso NF, Prieto J, Bujanda L, Drenth JPH, Banales JM, Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease. J HEPATOL 2015;63 (4):952-961 [PubMed]
Oude Elferink RPJ, Bolier R , Beuers UH, Lysophosphatidic acid and signaling in sensory neurons. BBA-MOL CELL BIOL L 2015;1851 (1):61-65 [PubMed]
Rademaker AAEM, Benninga MA, Beuers UHW, Plötz FB, Een kind met primaire scleroserende cholangitis. NED TIJDSCHR GENEESKD 2015;159:A8312 [PubMed]
Runge JH. Towards quantitative magnetic resonance assessment in parenchymal liver disease. S.l.: s.n.; 2015. 149p. ISBN 9789491602306 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Stoker J, Beuers UHW; copromotor(s): Nederveen AJ)
Slijepcevic D, Kaufman C, Wichers CGK, Gilglioni EH, Lempp FA, Duijst S, de Waart DR, Elferink RPJO, Mier W, Stieger B, Beuers U, Urban S, van de Graaf SFJ, Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. HEPATOLOGY 2015;62 (1):207-219 [PubMed]
van der Woerd WL. ATP8B1 deficiency: Steps towards personalized therapy. S.l.: s.n.; 2015. 159p. ISBN 978-94-6259-882-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW; copromotor(s): Houwen RHJ, van de Graaf KFJ)
van der Woerd WL, Mulder J, Pagani F, Beuers U, Houwen RHJ, van de Graaf SFJ, Analysis of aberrant pre-messenger RNA splicing resulting from mutations in ATP8B1 and efficient in vitro rescue by adapted U1 small nuclear RNA. HEPATOLOGY 2015;61 (4):1382-1391 [PubMed]
van Dijk R, Beuers U, Bosma PJ, Gene replacement therapy for genetic hepatocellular jaundice. CLIN REV ALLERG IMMU 2015;48 (2-3):243-253 [PubMed]
van Dijk R, Kremer AE, Smit W, van den Elzen B, van Gulik T, Gouma D, Lameris JS, Bikker H, Enemuo V, Stokkers PCF, Feist M, Bosma P, Jansen PLM, Beuers U, Characterization and treatment of persistent hepatocellular secretory failure. LIVER INT 2015;35 (4):1478-1488 [PubMed]
van Dijk R, Mayayo-Peralta I, Aronson SJ, Kattentidt-Mouravieva AA, van der Mark VA, de Knegt R, Oruc N, Beuers U, Bosma PJ, Disruption of HNF1α binding site causes inherited severe unconjugated hyperbilirubinemia. J HEPATOL 2015;63 (6):1525-1529 [PubMed]
van Gerven NMF, de Boer YS, Zwiers A, Verwer BJ, Drenth JPH, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MMJ, Vrolijk JM, Coenraad MJ, Kraal G, Mulder CJJ, van Nieuwkerk CMJ, Bloemena E, Verspaget HW, Kumar V, Zhernakova A, Wijmenga C, Franke L, Bouma G [Contributors: Baak LC, Baven-Pronk AM, Klempt-Kropp M, van Meyel JJM, Linskens RK, Spanier BW, Kneppelhout JC, Kuyvenhoven JP, van Geenen EJM, Wagtmans MJ, Cahen DL, Wolfhagen FHJ, Kingma PJ, de Vree JML, Loffeld RJLF, de Man RA, Friederich PW, Schreuder TCMA, van Milligen de Wit AWM, Alleman MA, Bhalla A, Stadhouders PHGM, Verhagen MAMT]] , HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1. GENES IMMUN 2015;16 (4):247-252 [PubMed]
van Lent AU, Takkenberg RB, van Eeden S, Mulder C, Beuers U, Chronic diarrhea because of villous atrophy unrelated to celiac disease. ENDOSCOPY 2015;47 (Suppl. 1 UCTN):E71-E72 [PubMed]
Wagner A, Denzer UW, Neureiter D, Kiesslich T, Puespoeck A, Rauws EAJ, Emmanuel K, Degenhardt N, Frick U, Beuers U, Lohse AW, Berr F, Wolkersdörfer GW, Temoporfin improves efficacy of photodynamic therapy in advanced biliary tract carcinoma: A multicenter prospective phase II study. HEPATOLOGY 2015;62 (5):1456-1465 [PubMed]
Berden FAC, Kievit W, Baak LC, Bakker CM, Beuers U, Boucher CAB, Brouwer JT, Burger DM, van Erpecum KJL, van Hoek B, Hoepelman AIM, Honkoop P, Kerbert-Dreteler MJ, de Knegt RJ, Koek GH, van Nieuwkerk CMJ, van Soest H, Tan ACITL, Vrolijk JM, Drenth JPH, Dutch guidance for the treatment of chronic hepatitis C virus infection in a new therapeutic era. NETH J MED 2014;72 (8):388-400 [PubMed]
Beuers U, Kremer AE, Bolier R , Elferink RPJO, Pruritus in cholestasis: facts and fiction. HEPATOLOGY 2014;60 (1):399-407 [PubMed]
Beuers U, Maillette de Buy Wenniger LJ, Doorenspleet M, Hubers L, Verheij J, van Gulik T, van de Graaf SFJ, de Vries N, IgG4-associated cholangitis. DIGEST DIS 2014;32 (5):605-608 [PubMed]
Bieze M, Klümpen HJ, Verheij J, Beuers U, Phoa SSKS, van Gulik TM, Bennink RJ, Diagnostic Accuracy of (18) F-Methylcholine Positron Emission Tomography/Computed Tomography for Intra- and Extrahepatic Hepatocellular Carcinoma. HEPATOLOGY 2014;59 (3):996-1006 [PubMed]
Bolier AR, Jebbink JM, van der Post JAM, Oude Elferink RPJ, Beuers U, Intrahepatische zwangerschapscholestase: riskante jeuk. NED TIJDSCHR GENEESKD 2014;158:A7713 [PubMed]
Boonstra K. Primary sclerosing cholangitis and primary biliary cirrhosis: epidemiology, risk factors, and outcome. S.l.: s.n.; 2014. 165p. ISBN 9789462593336 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW; copromotor(s): Ponsioen CI)
Boonstra K, Bokelaar R, Stadhouders PH, Tuynman HA, Poen AC, van Nieuwkerk KM, Witteman EM, Hamann D, Witteman BJ, Beuers U, Ponsioen CY, Increased cancer risk in a large population-based cohort of patients with primary biliary cirrhosis: follow-up for up to 36 years. HEPATOL INT 2014;8 (2):266-274 [PubMed]
Boonstra K, Culver EL, de Buy Wenniger LM, van Heerde MJ, van Erpecum KJ, Poen AC, van Nieuwkerk KMJ, Spanier BWM, Witteman BJM, Tuynman HARE, van Geloven N, van Buuren H, Chapman RW, Barnes E, Beuers U, Ponsioen CY, Serum Immunoglobulin G4 and Immunoglobulin G1 for Distinguishing Immunoglobulin G4-Associated Cholangitis From Primary Sclerosing Cholangitis. HEPATOLOGY 2014;59 (5):1954-1963 [PubMed]
Boonstra K, Kunst AE, Stadhouders PH, Tuynman HA, Poen AC, van Nieuwkerk KMJ, Witteman EM, Hamann D, Witteman BJ, Beuers U, Ponsioen CY [Contributors: Abilakh Missier ET, Baak LC, van Bentem N, van den Brande JM, Brink MA, Bruins Slot W, van Buuren HR, Cahen DL, Depla AC, Drenth JP, van Erpecum KJ, de Groot G, van den Hazel SJ, van Hoek B, Kingma PJ, Klompmaker IJ, Kuyvenhoven JP, Ledeboer M, Loffeld BC, Loffeld RJ, Mallant-Hent RC, Naber AH, Oosting PR, Riemens SC, Schmidt Böhmer J, Scholten P, Spanier BWM, Tan G, Teunen A, Thijs JC, Verhagen MA, Viergever PP, Vrij AA, Weersma RK, Weinhardt O]] , Rising incidence and prevalence of primary biliary cirrhosis: a large population-based study. LIVER INT 2014;34 (6):e31-e38 [PubMed]
Buijs J, Maillette de Buy Wenniger L, van Leenders G, Verheij J, van Onna I, Hansen B, van Heerde M, Krak N, Beuers U, Bruno M, van Buuren H, Immunoglobulin G4-related prostatitis: a case-control study focusing on clinical and pathologic characteristics. UROLOGY 2014;83 (3):521-526 [PubMed]
Buijs J, van Heerde MJ, Rauws EAJ, de Buy Wenniger LJM, Hansen BE, Biermann K, Verheij J, Vleggaar FP, Brink MA, Beuers UHW, Kuipers EJ, Bruno MJ, van Buuren HR, Comparable efficacy of low- versus high-dose induction corticosteroid treatment in autoimmune pancreatitis. PANCREAS 2014;43 (2):261-267 [PubMed]
de Boer YS, van Gerven NMF, Zwiers A, Verwer BJ, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, Drenth JPH, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MMJ, Vrolijk JM, Kraal G, Mulder CJJ, van Nieuwkerk CMJ, Fischer J, Berg T, Stickel F, Sarrazin C, Schramm C, Lohse AW, Weiler-Normann C, Lerch MM, Nauck M, Volzke H, Homuth G, Bloemena E, Verspaget HW, Kumar V, Zhernakova A, Wijmenga C, Franke L, Bouma G [Contributors: Baak LC, Baven-Pronk AM, Coenraad MJ, Klemt-Kropp M, van Meyel JJM, Linskens RK, Spanier BW, Kneppelhout JC, Kuyvenhoven JP, van Geenen EJM, Wagtmans MJ, Cahen DL, Wolfhagen FHJ, Kingma PJ, de Vree JML, Loffeld RJLF, de Man RA, Friederich W, Schreuder TCMA, van Milligen de Wit AWM, Alleman MA, Bhalla A, Stadhouders PHGM, Verhagen MAMT, Alizadeh B, de Boer R, Boezen HM, Bruinenberg M, van der Harst P, Hillege H, van der Klauw M, Navis G, Ormel J, Postma D, Rosmalen J, Slaets J, Snieder H, Stolk R, Wolffenbuttel B, Mayerle J]] , Genome-wide association study identifies variants associated with autoimmune hepatitis type 1. GASTROENTEROLOGY 2014;147 (2):443-52.e5 [PubMed]
de Buy Wenniger LJM, Culver EL, Beuers U, Exposure to occupational antigens might predispose to IgG4-related disease. HEPATOLOGY 2014;60 (4):1453-1454 [PubMed]
Dilger K, Hohenester S, Winkler-Budenhofer U, Bastiaansen BAJ, Schaap FG, Rust C, Beuers U, Corrigendum to: "Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health" [J Hepatol 2012;57:133-140]. J HEPATOL 2014;60 (3):684 [PubMed]
Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M, Characterization of animal models for primary sclerosing cholangitis (PSC). J HEPATOL 2014;60 (6):1290-1303 [PubMed]
Gotthardt DN, Sauer P, Schaible A, Stern J, Stiehl A, Beuers U, Kinetics of primary bile acids in patients after proctocolectomy and ileal pouch-anal anastomosis. DIGESTION 2014;90 (1):27-32 [PubMed]
Jebbink J, Tabbers M, Afink G, Beuers U, Oude Elferink R, Ris-Stalpers C, van der Post J, HELLP syndrome preceded by intrahepatic cholestasis of pregnancy: one serious itch. BMJ CASE REP 2014;2014:bcr2013203208 [PubMed]
Kremer AE, Bolier R , van Dijk R, Oude Elferink RPJ, Beuers U, Advances in pathogenesis and management of pruritus in cholestasis. DIGEST DIS 2014;32 (5):637-645 [PubMed]
Kremer AE, Feramisco J, Reeh PW, Beuers U, Oude Elferink RPJ, Receptors, cells and circuits involved in pruritus of systemic disorders. BBA-MOL BASIS DIS 2014;1842 (7):869-892 [PubMed]
Leopold SJ, Grady BPX, Lindenburg CEA, Prins M, Beuers U, Weegink CJ, Common Bile Duct Dilatation in Drug Users With Chronic Hepatitis C Is Associated With Current Methadone Use. J ADDICT MED 2014;8 (1):53-58 [PubMed]
Taegtmeyer AB, Haschke M, Tchambaz L, Buylaert M, Tschöpl M, Beuers U, Drewe J, Krähenbühl S, A study of the relationship between serum bile acids and propranolol pharmacokinetics and pharmacodynamics in patients with liver cirrhosis and in healthy controls. PLOS ONE 2014;9 (6):e97885 [PubMed]
van de Graaf S, Beuers U, Autophagy - another piece of the puzzle towards understanding primary biliary cirrhosis?. LIVER INT 2014;34 (4):481-483 [PubMed]
van Gerven NMF, Verwer BJ, Witte BI, van Erpecum KJ, van Buuren HR, Maijers I, Visscher AP, Verschuren EC, van Hoek B, Coenraad MJ, Beuers UHW, de Man RA, Drenth JPH, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MMJ, Vrolijk JM, Mulder CJJ, van Nieuwkerk CMJ, Bouma G, Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands. SCAND J GASTROENTERO 2014;49 (10):1245-1254 [PubMed]
van Heerde MJ, Buijs J, Rauws EA, de Buy Wenniger LJM, Hansen BE, Biermann K, Verheij J, Vleggaar FP, Brink MA, Beuers UHW, Kuipers EJ, van Buuren HR, Bruno MJ, A comparative study of diagnostic scoring systems for autoimmune pancreatitis. PANCREAS 2014;43 (4):559-564 [PubMed]
Wiggers JK, Ruys AT, Groot Koerkamp B, Beuers U, ten Kate FJ, van Gulik TM, Differences in immunohistochemical biomarkers between intra- and extrahepatic cholangiocarcinoma: a systematic review and meta-analysis. J GASTROEN HEPATOL 2014;29 (8):1582-1594 [PubMed]
Beuers U, β1 integrin is a long-sought sensor for tauroursodeoxycholic acid. HEPATOLOGY 2013;57 (3):867-869 [PubMed]
Bieze M, Bennink RJ, El-Massoudi Y, Phoa SSKS, Verheij J, Beuers U, van Gulik TM, The use of 18F-fluoromethylcholine PET/CT in differentiating focal nodular hyperplasia from hepatocellular adenoma: a prospective study of diagnostic accuracy. NUCL MED COMMUN 2013;34 (2):146-154 [PubMed]
Bolier R , Oude Elferink RPJ, Beuers U, Advances in pathogenesis and treatment of pruritus. CLIN LIVER DIS 2013;17 (2):319-329 [PubMed]
Boonstra K, Weersma RK, van Erpecum KJ, Rauws EA, Spanier BWM, Poen AC, van Nieuwkerk KM, Drenth JP, Witteman BJ, Tuynman HA, Naber AH, Kingma PJ, van Buuren HR, van Hoek B, Vleggaar FP, van Geloven N, Beuers U, Ponsioen CY [Contributors: Abilakh Missier ET, Baak LC, van Bentem N, van den Brande JM, Brink MA, Bruins Slot W, Cahen DL, Claessen MM, Depla AC, de Groot G, van den Hazel SJ, Janse M, Klompmaker IJ, Korkmaz KS, Kuyvenhoven JP, Ledeboer M, Loffeld BC, Loffeld RJ, Mallant-Hent RC, Oosting PR, Riemens SC, Schmidt Böhmer J, Scholten P, Stadhouders PH, Tan G, Teunen A, Thijs JC, Verhagen MA, Viergever PP, Vrij AA, Weinhardt O, Witteman EM]] , Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis. HEPATOLOGY 2013;58 (6):2045-2055 [PubMed]
de Buy Wenniger LM, Scheltema JM, Verheij J, Beuers U, Testicular inflammation as a new manifestation of IgG4-associated disease. UROLOGY 2013;82 (2):e15-e16 [PubMed]
Hoekstra LT, Bieze M, Erdogan D, Roelofs JJTH, Beuers UHW, van Gulik TM, Management of giant liver hemangiomas: an update. EXPERT REV GASTROENT 2013;7 (3):263-268 [PubMed]
Hohenester S, Beuers U, Medina JF, Elferink RPO, Antimitochondrial antibodies may be insufficiently specific to define primary biliary cirrhosis-like disease in mouse models. HEPATOLOGY 2013;58 (2):828-830 [PubMed]
Maillette de Buy Wenniger LJ, Doorenspleet ME, Klarenbeek PL, Verheij J, Baas F, Elferink RPO, Tak PP, de Vries N, Beuers U, Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis. HEPATOLOGY 2013;57 (6):2390-2398 [PubMed]
Maillette de Buy Wenniger LJ, Doorenspleet ME, Verheij J, de Vries N, Beuers U, IgG4-gerelateerde ziekte. NED TIJDSCHR GENEESKD 2013;157 (46):A6476 [PubMed]
Marschall HU, Beuers U, When bile acids don't get amidated. GASTROENTEROLOGY 2013;144 (5):870-873 [PubMed]
Sjouke B, Balak DMW, Beuers U, Ratziu V, Stroes ESG, Is mipomersen ready for clinical implementation? A transatlantic dilemma. CURR OPIN LIPIDOL 2013;24 (4):301-306 [PubMed]
Timmer MR, Beuers U, Fockens P, Ponsioen CY, Rauws EA, Wang KK, Krishnadath KK, Genetic and Epigenetic Abnormalities in Primary Sclerosing Cholangitis-associated Cholangiocarcinoma. INFLAMM BOWEL DIS 2013;19 (8):1789-1797 [PubMed]
van Dijk R, Montenegro-Miranda PS, Riviere C, Schilderink R, ten Bloemendaal L, van Gorp J, Duijst S, de Waart DR, Beuers U, Haisma HJ, Bosma PJ, Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver-directed gene therapy in vivo. HUM GENE THER 2013;24 (9):807-813 [PubMed]
van Gerven NMF, de Boer YS, Zwiers A, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, Drenth JPH, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MMJ, Vrolijk JM, Kraal G, Mulder CJJ, van Nieuwkerk CMJ, Bouma G [Contributors: Bloemena EB, Baak LC, Baven-Pronk AM, Coenraad MJ, Klempt- Kropp M, van Meyel JJM, Linskens RK, Spanier BW, Kneppelhout JC, Kuyvenhoven JP, van Geenen EJM, Wagtmans MJ, Cahen DL, Wolfhagen FHJ, Kingma PJ, de Vree JML, Loffeld RJLF, de Man RA, Friederich PW, van Milligen de Wit AWM, Schreuder TCMA, Alleman MA, Bhalla A, Stadhouders PHGM, Verhagen MAMT]] , Cytotoxic T lymphocyte antigen-4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis. LIVER INT 2013;33 (7):1039-1043 [PubMed]
van Gerven NMF, Verwer BJ, Witte BI, van Hoek B, Coenraad MJ, van Erpecum KJ, Beuers U, van Buuren HR, de Man RA, Drenth JPH, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MMJ, Mulder CJJ, van Nieuwkerk KMJ, Bouma G, Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission. J HEPATOL 2013;58 (1):141-147 [PubMed]
Bakker GJ, Haan YCL, Maillette de Buy Wenniger LJ, Beuers U, Sarcoidosis of the liver: to treat or not to treat?. NETH J MED 2012;70 (8):349-356 [PubMed]
Beuers U, Maroni L, Elferink RO, The biliary HCO3- umbrella: experimental evidence revisited. CURR OPIN GASTROEN 2012;28 (3):253-257 [PubMed]
Bolier AR, Peri S, Oude Elferink RPJ, Beuers U, The challenge of cholestatic pruritus. ACTA GASTRO-ENT BELG 2012;75 (4):399-404 [PubMed]
Boonstra K, Beuers U, Ponsioen CY, Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: A systematic review. J HEPATOL 2012;56 (5):1181-1188 [PubMed]
Boonstra K, van Erpecum KJ, van Nieuwkerk KMJ, Drenth JPH, Poen AC, Witteman BJM, Tuynman HARE, Beuers U, Ponsioen CY, Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease. INFLAMM BOWEL DIS 2012;18 (12):2270-2276 [PubMed]
Buster EHCJ, Baak BC, Bakker CM, Beuers UHW, Brouwer JT, Drenth JPH, van Erpecum KJ, van Hoek B, Honkoop P, Kerbert-Dreteler MJ, Koek GH, van Nieuwkerk KMJ, van Soest H, van der Spek BW, Tan ACITL, Vrolijk JM, Janssen HLA, The 2012 revised Dutch national guidelines for the treatment of chronic hepatitis B virus infection. NETH J MED 2012;70 (8):381-385 [PubMed]
de Bruijne J. Direct-acting antiviral therapy for chronic hepatitis C. s.l.: s.n.; 2012. 289p. ISBN 9789090267227 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers U, Jansen PLM; copromotor(s): Reesink HW, Molenkamp R)
de Niet A, Zaaijer HL, ten Berge I, Weegink CJ, Reesink HW, Beuers U, Chronic hepatitis E after solid organ transplantation. NETH J MED 2012;70 (6):261-266 [PubMed]
Dilger K, Hohenester S, Winkler-Budenhofer U, Bastiaansen BAJ, Schaap FG, Rust C, Beuers U, Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. J HEPATOL 2012;57 (1):133-140 [PubMed]
Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE, Bergquist A, Ryu E, Ponsioen CY, Runz H, Sterneck M, Vermeire S, Beuers U, Wijmenga C, Schrumpf E, Manns MP, Lazaridis KN, Schreiber S, Baines JF, Franke A, Karlsen TH, Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. J HEPATOL 2012;57 (2):366-375 [PubMed]
Hoekstra LT, Bieze M, Erdogan D, Roelofs JJTH, Beuers UHW, van Gulik TM, Het reuzenhemangioom in de lever: diagnostiek en behandeling. NED TIJDSCHR GENEESKD 2012;156 (31):A3820 [PubMed]
Hoekstra LT, Wakkie T, Busch ORC, Gouma DJ, Beuers U, van Gulik T, Predictors of posthepatectomy ascites with or without previous portal vein embolization. DIGEST SURG 2012;29 (6):468-474 [PubMed]
Hohenester S, Wenniger LMDB, Paulusma CC, van Vliet SJ, Jefferson DM, Elferink RPO, Beuers U, A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. HEPATOLOGY 2012;55 (1):173-183 [PubMed]
Jansen PLM, Beuers U, Oude Elferink RPJ. Mechanisms of Bile Secretion in: Boyer TD, Manns MP, Sanyal AJ, editors. Hepatology : A Textbook of Liver Disease (6th ed.). Philadelphia: Elsevier Saunders; 2012. 6, p. 20-36
Jansen PLM, Schaap FG, Beuers UHW, Fibroblast Growth Factor 19, an Anticholestatic Drug Produced by Human Liver. GASTROENTEROLOGY 2012;142 (3):E29-E30 [PubMed]
Kremer AE, Beuers U, Brushing of bile duct stenoses for the true dignity. LIVER INT 2012;32 (5):698-700 [PubMed]
Kremer AE, Oude Elferink RPJ, Beuers U, Cholestatic pruritus. New insights into pathophysiology and current treatment. HAUTARZT 2012;63 (7):532-538 [PubMed]
Kremer AE, van Dijk R, Leckie P, Schaap FG, Kuiper EMM, Mettang T, Reiners KS, Raap U, van Buuren HR, van Erpecum KJ, Davies NA, Rust C, Engert A, Jalan R, Oude Elferink RPJ, Beuers U, Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. HEPATOLOGY 2012;56 (4):1391-1400 [PubMed]
Maillette de Buy Wenniger LJ, Oude Elferink RP, Beuers U, Molecular Targets for the Treatment of Fibrosing Cholangiopathies. CLIN PHARMACOL THER 2012;92 (3):381-387 [PubMed]
Maillette de Buy Wenniger L, Rauws EA, Beuers U, What an endoscopist should know about immunoglobulin-G4-associated disease of the pancreas and biliary tree. ENDOSCOPY 2012;44 (1):66-73 [PubMed]
Montenegro-Miranda PS, Sneitz N, de Waart DR, ten Bloemendaal L, Duijst S, de Knegt RJ, Beuers U, Finel M, Bosma PJ, Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia. BBA-MOL BASIS DIS 2012;1822 (8):1223-1229 [PubMed]
Ständer S, Darsow U, Mettang T, Gieler U, Maurer M, Ständer H, Beuers U, Niemeier V, Gollnick H, Vogelgsang M, Weisshaar E, S2k-Leitlinie - Chronischer Pruritus. J DTSCH DERMATOL GES 2012;10 (4):S1-S27 [PubMed]
Visser ME, Wagener G, Baker BF, Geary RS, Donovan JM, Beuers UHW, Nederveen AJ, Verheij J, Trip MD, Basart DCG, Kastelein JJP, Stroes ESG, Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial. EUR HEART J 2012;33 (9):1142-1149 [PubMed]
Baven-Pronk AMC, Coenraad MJ, van Buuren HR, de Man RA, van Erpecum KJ, Lamers MMH, Drenth JPH, van den Berg AP, Beuers UH, den Ouden J, Koek GH, van Nieuwkerk CMJ, Bouma G, Brouwer JT, van Hoek B, Mycophenolate mofetil for patients with autoimmune hepatitis and overlap syndromes: authors' reply. ALIMENT PHARM THER 2011;34 (6):684-685 [PubMed]
Baven-Pronk AMC, Coenraad MJ, van Buuren HR, de Man RA, van Erpecum KJ, Lamers MMH, Drenth JPH, van den Berg AP, Beuers UH, den Ouden J, Koek GH, van Nieuwkerk CMJ, Bouma G, Brouwer JT, van Hoek B, The role of mycophenolate mofetil in the management of autoimmune hepatitis and overlap syndromes. ALIMENT PHARM THER 2011;34 (3):335-343 [PubMed]
Beuers U, Lindor KD, A major step towards effective treatment evaluation in primary biliary cirrhosis. J HEPATOL 2011;55 (6):1178-1180 [PubMed]
Hohenester S, Beuers U, Phosphatidylcholines as regulators of glucose and lipid homeostasis: Promises and potential risks. HEPATOLOGY 2011;54 (6):2266-2268 [PubMed]
Hohenester S, Maillette de Buy Wenniger L, Jefferson DM, Oude Elferink RP, Beuers U, Biliary bicarbonate secretion constitutes a protective mechanism against bile acid-induced injury in man. DIGEST DIS 2011;29 (1):62-65 [PubMed]
Hopf C, Beuers U, Bikker H, Denk GU, Rust C, 44-jährige Patientin mit unklarer Leberwerterhöhung und familiär gehäuftem Gallensteinleiden. INTERNIST 2011;52 (10):1234-1237 [PubMed]
Kremer AE, Maillette de Buy Wenniger L, Oude Elferink RPJ, Beuers U, Pruritus bij leverziekten. Pathogenese en behandeling. NED TIJDSCHR GENEESKD 2011;155 (52):A4045 [PubMed]
Kremer AE, Oude Elferink RPJ, Beuers U, Pathophysiology and current management of pruritus in liver disease. CLIN RES HEPATOL GAS 2011;35 (2):89-97 [PubMed]
Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M, Porte RJ, Holm K, Gieger C, Wichmann HE, Stokkers P, Ponsioen CY, Runz H, Stiehl A, Wijmenga C, Sterneck M, Vermeire S, Beuers U, Villunger A, Schrumpf E, Lazaridis KN, Manns MP, Schreiber S, Karlsen TH, Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. NAT GENET 2011;43 (1):17-19 [PubMed]
Oude Elferink RP, Beuers U, Targeting the ABCB4 gene to control cholesterol homeostasis. EXPERT OPIN THER TAR 2011;15 (10):1173-1182 [PubMed]
Oude Elferink RPJ, Kremer AE, Martens JJWW, Beuers UH, The molecular mechanism of cholestatic pruritus. DIGEST DIS 2011;29 (1):66-71 [PubMed]
Oude Elferink RP, Kremer AE, Beuers U, Mediators of pruritus during cholestasis. CURR OPIN GASTROEN 2011;27 (3):289-293 [PubMed]
Stieger B, Beuers U, The canalicular bile salt export pump BSEP (ABCB11) as a potential therapeutic target. CURR DRUG TARGETS 2011;12 (5):661-670 [PubMed]
van den Esschert JW, Bieze M, Beuers UH, van Gulik TM, Bennink RJ, Differentiation of hepatocellular adenoma and focal nodular hyperplasia using (18)F-fluorocholine PET/CT. EUR J NUCL MED MOL I 2011;38 (3):436-440 [PubMed]
Vlaar APJ, Rietdijk ST, Zeerleder SS, Boerman T, Beuers U, Malignancies associated with chronic hepatitis C: case report and review of the literature. NETH J MED 2011;69 (5):211-215 [PubMed]
Wellge BE, Sterneck M, Teufel A, Rust C, Franke A, Schreiber S, Berg T, Günther R, Kreisel W, Zu Eulenburg C, Braun F, Beuers U, Galle PR, Lohse AW, Schramm C, Pregnancy in primary sclerosing cholangitis. GUT 2011;60 (8):1117-1121 [PubMed]
Beuers U. Biliary Infections in: Dancygier H, editor. Clinical Hepatology - Principles and Practice of Hepatobiliary Diseases. Heidelberg: Springer; 2010. 2, p. 1493-1502
Beuers U. Physiology of the Gallbladder and the Extrahepatic Bile Ducts in: Dancygier H, editor. Clinical Hepatology - Principles and Practice of Hepatobiliary Diseases. Heidelberg: Springer; 2010. 2, p. 1423-1426
Beuers U, Dancygier H. Gross and Microscopic Anatomy in: Dancygier H, editor. Clinical Hepatology - Principles and Practice of Hepatobiliary Diseases. Heidelberg: Springer; 2010. 2, p. 1417-1421
Beuers U, Hohenester S, de Buy Wenniger LJM, Kremer AE, Jansen PLM, Oude Elferink RPJ, The biliary HCO(3) (-) umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. HEPATOLOGY 2010;52 (4):1489-1496 [PubMed]
Boonstra K, Ponsioen CI, Rauws EAJ, Beuers UHW, Primaire scleroserende cholangitis. NED TIJDSCHR GENEESKD 2010;154 (21):A1476 [PubMed]
Denk GU, Bikker H, Lekanne dit Deprez RH, Terpstra V, van der Loos C, Beuers U, Rust C, Pusl T, ABCB4 deficiency: A family saga of early onset cholelithiasis, sclerosing cholangitis and cirrhosis and a novel mutation in the ABCB4 gene. HEPATOL RES 2010;40 (9):937-941 [PubMed]
Denk GU, Maitz S, Wimmer R, Rust C, Invernizzi P, Ferdinandusse S, Kulik W, Fuchsbichler A, Fickert P, Trauner M, Hofmann AF, Beuers U, Conjugation Is Essential for the Anticholestatic Effect of NorUrsodeoxycholic Acid in Taurolithocholic Acid-Induced Cholestasis in Rat Liver. HEPATOLOGY 2010;52 (5):1758-1768 [PubMed]
Heger M, de Graaf W, Bennink RJ, Beuers U, van Gulik TM, A Clinical Perspective on the Criteria for Liver Resection and the Use of Liver Function Tests. WORLD J SURG 2010;34 (4):868-869 [PubMed]
Hohenester S, Gates A, Wimmer R, Beuers U, Anwer MS, Rust C, Webster CRL, Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. J HEPATOL 2010;53 (5):918-926 [PubMed]
Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, Elsharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH, Stokkers PCF, Vermeire S, Mathew CG, Lie BA, Beuers U, Manns MP, Schreiber S, Schrumpf E, Häussinger D, Franke A, Karlsen TH, Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis. PLOS ONE 2010;5 (8):e12403 [PubMed]
Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EER, Fritz T, Henckaerts L, Weersma R, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P, Stiehl A, Vermeire S, Beuers U, Manns M, Schrumpf E, Boberg KM, Schreiber S, Genome-Wide Association Analysis in Primary Sclerosing Cholangitis. GASTROENTEROLOGY 2010;138 (3):1102-1111 [PubMed]
Kloek JJ, Heger M, van der Gaag NA, Beuers U, van Gulik TM, Gouma DJ, Levi M, Effect of Preoperative Biliary Drainage on Coagulation and Fibrinolysis in Severe Obstructive Cholestasis. J CLIN GASTROENTEROL 2010;44 (9):646-652 [PubMed]
Kremer AE, Martens JJWW, Kulik W, Ruëff F, Kuiper EMM, van Buuren HR, van Erpecum KJ, Kondrackiene J, Prieto J, Rust C, Geenes VL, Williamson C, Moolenaar WH, Beuers U, Elferink RPJO, Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus. GASTROENTEROLOGY 2010;139 (3):1008-U399 [PubMed]
Kuiper EMM, van Erpecum KJ, Beuers U, Hansen BE, Thio HB, de Man RA, Janssen HLA, van Buuren HR, The Potent Bile Acid Sequestrant Colesevelam Is Not Effective in Cholestatic Pruritus: Results of a Double-Blind, Randomized, Placebo-Controlled Trial. HEPATOLOGY 2010;52 (4):1334-1340 [PubMed]
Maillette de Buy Wenniger L, Beuers U, Bile salts and cholestasis. DIGEST LIVER DIS 2010;42 (6):409-418 [PubMed]
Maillette de Buy Wenniger L, Terpstra V, Beuers U, Focal Nodular Hyperplasia and Hepatic Adenoma: Epidemiology and Pathology. DIGEST SURG 2010;27 (1):24-31 [PubMed]
Rust C, Beuers U, Learning from the pregnane X receptor: how to fight one aggressor with two strategies. LIVER INT 2010;30 (2):161-163 [PubMed]
Alderlieste YA, van den Elzen BDJ, Rauws EAJ, Beuers U, Immunoglobulin G4-Associated Cholangitis: One Variant of Immunoglobulin G4-Related Systemic Disease. DIGESTION 2009;79 (4):220-228 [PubMed]
Beuers U, Crosstalk of liver, bile ducts and the gut. CLIN REV ALLERG IMMU 2009;36 (1):1-3 [PubMed]
Beuers U, Prof. Raoul Poupon. J HEPATOL 2009;51 (4):617-619 [PubMed]
Beuers U, Göke B, GLP-1 analogues: a new therapeutic approach to prevent ductopenia in cholangiopathies?. GUT 2009;58 (7):902-903 [PubMed]
Beuers U, Kullak-Ublick GA, Pusl T, Rauws ER, Rust C, Medical Treatment of Primary Sclerosing Cholangitis: A Role for Novel Bile Acids and other (post-)Transcriptional Modulators?. CLIN REV ALLERG IMMU 2009;36 (1):52-61 [PubMed]
Beuers U, Rauws EA, ter Borg PCJ, van Buuren HR, Koek G. Cholestatische Leverziekten in: Janssen HLA, Drenth JPH, van Hoek B, editors. Leverziekten. Houten: bohn Stafleu van Loghum; 2009., p. 100-107
Beuers U, Trauner M, Ursodeoxycholic acid in primary biliary cirrhosis: Reply. J HEPATOL 2009;51 (6):1085-1086 [PubMed]
Hohenester S. Zur Bedeutung von Proteinkinasen und Phosphatidylinositol-Kinasen für (anti-) cholestatische und (anti-) apoptotische Effekte von Gallensäuren in der Leberzelle. S.l.: s.n.; 2009. 142p. Proefschrift Uni München, -. (Promotor(s): Beuers UHW; copromotor(s): )
Hohenester S, Oude-Elferink RPJ, Beuers U, Primary biliary cirrhosis. SEMIN IMMUNOPATHOL 2009;31 (3):283-307 [PubMed]
Kremer AE, Rust C, Eichhorn P, Beuers U, Holdenrieder S, Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers. EXPERT REV MOL DIAGN 2009;9 (2):139-156 [PubMed]
Oude Elferink R, Beuers U, Are pigs more human than mice?. J HEPATOL 2009;50 (4):838-841 [PubMed]
Rust C, Wild N, Bernt C, Vennegeerts T, Wimmer R, Beuers U, Bile Acid-induced Apoptosis in Hepatocytes Is Caspase-6-dependent. J BIOL CHEM 2009;284 (5):2908-2916 [PubMed]
Stiehl A, Trauner M, Beuers U, Keppler D, editors, Bile acid biology and therapeutic actions. Dordrecht: Springer; 2009. 293p.
Wild N. Molekulare Mechanismen und Modulation der Gallensäuren-induzierten Apoptose in einer humanen Hepatomzelllinie. S.l.: s.n.; 2009. 117p. Proefschrift Uni München, -. (Promotor(s): Beuers UHW; copromotor(s): )
[Contributors: Beuers U, Boberg KM, Chapman RW, Chazouillères O, Invernizzi P, Jones DEJ, Lammert F, Parès A, Trauner M]] , EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J HEPATOL 2009;51 (2):237-267 [PubMed]
Balkema S, Hamaker ME, Visser HPJ, Heine GDN, Beuers U, Haemolytic anaemia as a first sign of Wilson's disease. NETH J MED 2008;66 (8):344-347 [PubMed]
Beuers U, Oude-Elferink RPJ, New light on anion exchangers in primary biliary cirrhosis. J HEPATOL 2008;49 (6):881-883 [PubMed]
Bogdanos D, Pusl T, Rust C, Vergani D, Beuers U, Primary biliary cirrhosis following lactobacillus vaccination for recurrent vaginitis. J HEPATOL 2008;49 (3):466-473 [PubMed]
Cullen SN, Rust C, Fleming K, Edwards C, Beuers U, Chapman RW, High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective. J HEPATOL 2008;48 (5):792-800 [PubMed]
Denk GU, Hohenester S, Wimmer R, Boehland C, Rust C, Beuers U, Role of mitogen-activated protein kinases in tauroursodeoxycholic acid-induced bile formation in cholestatic rat liver. HEPATOL RES 2008;38 (7):717-726 [PubMed]
Kolligs FT, Zech CJ, Schönberg SO, Schirra J, Thasler W, Graeb C, Beuers U, Wilkowski R, Jacobs T, Böck S, Berster J, Heinemann V, Schäfer C, Interdisziplinäre Diagnostik und Therapie von Gallengangskarzinomen. Z GASTROENTEROL 2008;46 (1):58-68 [PubMed]
Kremer AE, Beuers U, Oude-Elferink RPJ, Pusl T, Pathogenesis and Treatment of Pruritus in Cholestasis. DRUGS 2008;68 (15):2163-2182 [PubMed]
Kremer AE, Budenhofer U, Beuers U, Rust C, 47-jähriger Hundezüchter mit chronischer Polyarthritis, Gewichtsverlust und hohem Fieber. Z GASTROENTEROL 2008;46 (5):431-434 [PubMed]
Löhe F, Angele MK, Rentsch M, Graeb C, Gerbes A, Löhrs U, Beuers U, Jauch KW, Multifocal manifestation does not affect vascular invasion of hepatocellular carcinoma: implications for patient selection in liver transplantation. CLIN TRANSPLANT 2008;21 (6):696-701 [PubMed]
Pusl T, Vennegeerts T, Wimmer R, Denk GU, Beuers U, Rust C, Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1. BIOCHEM BIOPH RES CO 2008;367 (1):208-212 [PubMed]
Rust C, Beuers U, Overlap syndromes among autoimmune liver diseases. WORLD J GASTROENTERO 2008;14 (21):3368-3373 [PubMed]
Von Hahn T, Halangk J, Witt H, Neumann K, Müller T, Puhl G, Neuhaus P, Nickel R, Beuers U, Wiedenmann B, Berg T, Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease. SCAND J GASTROENTERO 2008;43 (5):584-592 [PubMed]
Wimmer R, Hohenester S, Pusl T, Denk GU, Rust C, Beuers U, Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. GUT 2008;57 (10):1448-1454 [PubMed]
Beuers U. Cholangitis and biliary infections in: Rodes J, Benhamou JP, Blei AT, Reichen J, Rizetto M, editors. Textbook of Hepatology. S.l.: Blackwell Publishing; 2007., p. 1541-1549
Beuers U. Overlap syndromes in: Rodes J, Benhamou JP, Blei AT, Reichen J, Rizetto M, editors. Textbook of Hepatology. S.l.: Blackwell Publishing; 2007., p. 1120-1126
Beuers U, Rust C. Overlap syndromes of autoimmune hepatitis with primary biliary cirrhosis and primary sclerosing cholangitis in: Gershwin ME, Vierling JM, Manns MP, editors. Liver Immunology. S.l.: Humana Press; 2007., p. 285-292
Holdenrieder S, Eichhorn P, Beuers U, Samtleben W, Stieber P, Nagel D, Peterfi A, Steinle A, Salih HR, Soluble NKG2D ligands in hepatic autoimmune diseases and in benign diseases involved in marker metabolism. ANTICANCER RES 2007;27 (4A):2041-2045 [PubMed]
Kondrackiene J, Beuers U, Zalinkevicius R, Tauschel HD, Gintautas V, Kupcinskas L, Predictors of premature delivery in patients with intrahepatic cholestasis of pregnancy. WORLD J GASTROENTERO 2007;13 (46):6226-6230 [PubMed]
Lang C, Meier Y, Stieger B, Beuers U, Lang T, Kerb R, Kullak-Ublick GA, Meier PJ, Pauli-Magnus C, Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. PHARMACOGENET GENOM 2007;17 (1):47-60 [PubMed]
Pusl T, Beuers U, Intrahepatic cholestasis of pregnancy. ORPHANET J RARE DIS 2007;2:26 [PubMed]
Stadlbauer V, Krisper P, Beuers U, Haditsch B, Schneditz D, Jung A, Putz-Bankuti C, Holzer H, Trauner M, Stauber RE, Removal of bile acids by two different extracorporeal liver support systems in acute-on-chronic liver failure. ASAIO J 2007;53 (2):187-193 [PubMed]
Bernt C. Molekulare mechanismen der Gallensäuren-vermittelten Apoptoseinduktion und deren transkriptionelle Modulation in einer humanen Hepatomzelllinie. S.l.: s.n.; 2006. 216p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW; copromotor(s): )
Bernt C, Vennegeerts T, Beuers U, Rust C, The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis. BIOCHEM BIOPH RES CO 2006;340 (3):800-806 [PubMed]
Beuers U, Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis. NAT CLIN PRACT GASTR 2006;3 (6):318-328 [PubMed]
Beuers U, Gerken G, Pusl T, Biliary drainage transiently relieves intractable pruritus in primary biliary cirrhosis. HEPATOLOGY 2006;44 (1):280-281 [PubMed]
Beuers U, Pusl T, Intrahepatic cholestasis of pregnancy--a heterogeneous group of pregnancy-related disorders?. HEPATOLOGY 2006;43 (4):647-649 [PubMed]
Denk A. Charakterisierung der durch hydrophobe Gallensäuren induzierten Leberzellschädigung und deren Modulation durch Phosphatidylinositol-3-Kinasen und Sulfasalazin. S.l.: s.n.; 2006. 55p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW; copromotor(s): )
Dilger K, Cascorbi I, Grünhage F, Hohenester S, Sauerbruch T, Beuers U, Multidrug resistance 1 genotype and disposition of budesonide in early primary biliary cirrhosis. LIVER INT 2006;26 (3):285-290 [PubMed]
Dombrowski F, Stieger B, Beuers U, Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. LAB INVEST 2006;86 (2):166-174 [PubMed]
Holdenrieder S, Eichhorn P, Beuers U, Samtleben W, Schoenermarck U, Zachoval R, Nagel D, Stieber P, Nucleosomal DNA fragments in autoimmune diseases. ANN NY ACAD SCI 2006;1075:318-327 [PubMed]
Hruz P, Zimmermann C, Gutmann H, Degen L, Beuers U, Terracciano L, Drewe J, Beglinger C, Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis. GUT 2006;55 (3):395-402 [PubMed]
Pusl T, Beuers U, Ursodeoxycholic acid treatment of vanishing bile duct syndromes. WORLD J GASTROENTERO 2006;12 (22):3487-3495 [PubMed]
Pusl T, Denk GU, Parhofer KG, Beuers U, Plasma separation and anion adsorption transiently relieve intractable pruritus in primary biliary cirrhosis. J HEPATOL 2006;45 (6):887-891 [PubMed]
Pusl T, Huettl TP, Beuers U, Gallbladder stones - a change in the interdisciplinary approach?. CHIR GASTROENTEROL 2006;22 (1):48-52
Rust C, Bauchmuller K, Bernt C, Vennegeerts T, Fickert P, Fuchsbichler A, Beuers U, Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers. GUT 2006;55 (5):719-727 [PubMed]
Schramm C, Herkel J, Beuers U, Kanzler S, Galle PR, Lohse AW, Pregnancy in autoimmune hepatitis: outcome and risk factors. AM J GASTROENTEROL 2006;101 (3):556-560 [PubMed]
Zimmermann C, Hruz P, Gutmann H, Terracciano L, Beuers U, Lehmann F, Beglinger C, Drewe J, Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis. DIGESTION 2006;74 (2):101-108 [PubMed]
Bauchmuller K. Der Effekt von Ursodeoxycholsäure auf den Cytochrom P450 3A Metabolismus bei primär biliärer Zirrhose und gesunden Probanden. S.l.: s.n.; 2005. 155p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Beuers UHW; copromotor(s): )
Beuers U, Hepatic overlap syndromes. J HEPATOL 2005;42 Suppl (1):S93-S99 [PubMed]
Beuers U, Rust C, Overlap syndromes. SEMIN LIVER DIS 2005;25 (3):311-320 [PubMed]
Dilger K, Denk A, Heeg MHJ, Beuers U, No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis. HEPATOLOGY 2005;41 (3):595-602 [PubMed]
Geier A, Dietrich CG, Grote T, Beuers U, Prüfer T, Fraunberger P, Matern S, Gartung C, Gerbes AL, Bilzer M, Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. J HEPATOL 2005;43 (6):1021-1030 [PubMed]
Kondrackiene J, Beuers U, Kupcinskas L, Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy. GASTROENTEROLOGY 2005;129 (3):894-901 [PubMed]
Pusl T, Beuers U, Extrahepatic manifestations of cholestatic liver diseases: pathogenesis and therapy. CLIN REV ALLERG IMMU 2005;28 (2):147-157 [PubMed]
Pusl T, Rhode F, Ott T, Drabent B, Willecke K, Beuers U, Gap junctional intercellular communication is not needed for the anticholestatic effect of tauroursodeoxycholic acid in mouse liver. J HEPATOL 2005;42 (4):604-605 [PubMed]
Rust C, Bauchmuller K, Fickert P, Fuchsbichler A, Beuers U, Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers. AM J PHYSIOL-GASTR L 2005;289 (1):G88-G94 [PubMed]
Rust C, Beuers U, Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis. CLIN REV ALLERG IMMU 2005;28 (2):135-145 [PubMed]
Wallnoefer AM, Herrmann KA, Beuers U, Zech CJ, Gourtsoyianni S, Reiser MF, Schoenberg SO, Vergleich von 2D- und 3D-Sequenzen für die MRCP. Klinischer Stellenwert der einzelnen Techniken. RADIOLOGE 2005;45 (11):993-4, 996-1003 [PubMed]
Wiegand J, Schüler A, Kanzler S, Lohse A, Beuers U, Kreisel W, Spengler U, Koletzko S, Jansen PLM, Hochhaus G, Möllmann HW, Pröls M, Manns MP, Budesonide in previously untreated autoimmune hepatitis. LIVER INT 2005;25 (5):927-934 [PubMed]
Denk GU, Soroka CJ, Mennone A, Koepsell H, Beuers U, Boyer JL, Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. HEPATOLOGY 2004;39 (5):1382-1389 [PubMed]
Kuchenbauer F, Strassburg CP, Vogel A, Hiddemann W, Beuers U, UGT1A7 polymorphisms, polycyclic aromatic hydrocarbons and the development of hepatocellular cancer. HEPATOLOGY 2004;40 (4):1021 [PubMed]
Pauli-Magnus C, Kerb R, Fattinger K, Lang T, Anwald B, Kullak-Ublick GA, Beuers U, Meier PJ, BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. HEPATOLOGY 2004;39 (3):779-791 [PubMed]
Pauli-Magnus C, Lang T, Meier Y, Zodan-Marin T, Jung D, Breymann C, Zimmermann R, Kenngott S, Beuers U, Reichel C, Kerb R, Penger A, Meier PJ, Kullak-Ublick GA, Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. PHARMACOGENETICS 2004;14 (2):91-102 [PubMed]
Paumgartner G, Beuers U, Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease. CLIN LIVER DIS 2004;8 (1):67-81, vi [PubMed]
Stauber RE, Krisper P, Zollner G, Iberer F, Beuers U, Trauner M, Extracorporeal albumin dialysis in a patient with primary sclerosing cholangitis: effect on pruritus and bile acid profile. INT J ARTIF ORGANS 2004;27 (4):342-344 [PubMed]
Terjung B, Bogsch F, Klein R, Söhne J, Reichel C, Wasmuth JC, Beuers U, Sauerbruch T, Spengler U, Diagnostic accuracy of atypical p-ANCA in autoimmune hepatitis using ROC- and multivariate regression analysis. EUR J MED RES 2004;9 (9):439-448 [PubMed]
Beuers U, Denk GU, Soroka CJ, Wimmer R, Rust C, Paumgartner G, Boyer JL, Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J BIOL CHEM 2003;278 (20):17810-17818 [PubMed]
Hempfling W, Dilger K, Beuers U, Systematic review: ursodeoxycholic acid--adverse effects and drug interactions. ALIMENT PHARM THER 2003;18 (10):963-972 [PubMed]
Hempfling W, Grunhage F, Dilger K, Reichel C, Beuers U, Sauerbruch T, Pharmacokinetics and pharmacodynamic action of budesonide in early- and late-stage primary biliary cirrhosis. HEPATOLOGY 2003;38 (1):196-202 [PubMed]
Ott SJ, Baron A, Berghaus T, Lamerz R, Beuers U, Liver failure in adult Still's disease during corticosteroid treatment. EUR J GASTROEN HEPAT 2003;15 (1):87-90 [PubMed]
Ott SJ, Helmberger T, Beuers U, Intestinal obstruction after ingestion of a beer-filled condom at the Munich Octoberfest. AM J GASTROENTEROL 2003;98 (2):512-513 [PubMed]
Probst I, Beuers U, Drabent B, Unthan-Fechner K, Bütikofer P, The diacylglycerol and protein kinase C pathways are not involved in insulin signalling in primary rat hepatocytes. EUR J BIOCHEM 2003;270 (23):4635-4646 [PubMed]
Rust C, Beuers U, Gallenblasen- und Gallenwegserkrankungen. MED MONATSSCHR PHARM 2003;26 (10):344-349 [PubMed]
Schwarze C, Terjung B, Lilienweiss P, Beuers U, Herzog V, Sauerbruch T, Spengler U, IgA class antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and autoimmune hepatitis. CLIN EXP IMMUNOL 2003;133 (2):283-289 [PubMed]
Glasova H, Berghaus TM, Kullak-Ublick GA, Paumgartner G, Beuers U, Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells. EUR J CLIN INVEST 2002;32 (6):437-442 [PubMed]
Glasova H, Beuers U, Extrahepatic manifestations of cholestasis. J GASTROEN HEPATOL 2002;17 (9):938-948 [PubMed]
Holzknecht N, Helmberger T, Beuers U, Rust C, Wiebecke B, Reiser M, Cross-sectional imaging findings in congenital intestinal lymphangiectasia. J COMPUT ASSIST TOMO 2002;26 (4):526-528 [PubMed]
Kenngott S, Lohse P, Beuers U, Intrahepatische Schwangerschaftscholestase. Woran Sie bei Gelbsucht und Juckreiz denken sollten. MMW FORTSCHR MED 2002;144 (50):41-44 [PubMed]
Kullak-Ublick GA, Baretton GB, Oswald M, Renner EL, Paumgartner G, Beuers U, Expression of the hepatocyte canalicular multidrug resistance protein (MRP2) in primary biliary cirrhosis. HEPATOL RES 2002;23 (1):78-82 [PubMed]
Paumgartner G, Beuers U, Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. HEPATOLOGY 2002;36 (3):525-531 [PubMed]
Pihusch R, Rank A, Göhring P, Pihusch M, Hiller E, Beuers U, Platelet function rather than plasmatic coagulation explains hypercoagulable state in cholestatic liver disease. J HEPATOL 2002;37 (5):548-555 [PubMed]
Welzel TM, Sauter GH, Beuers U, Nothdurft HD, Sackmann M, 31-jährige Patientin mit kolikartigen Oberbauchschmerzen und Eosinophilie. Fasziolose. INTERNIST 2002;43 (12):1593-1596 [PubMed]
Beuers U, Bilzer M, Chittattu A, Kullak-Ublick GA, Keppler D, Paumgartner G, Dombrowski F, Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. HEPATOLOGY 2001;33 (5):1206-1216 [PubMed]
Oswald M, Kullak-Ublick GA, Paumgartner G, Beuers U, Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis. LIVER 2001;21 (4):247-253 [PubMed]
Kullak-Ublick GA, Beuers U, Paumgartner G, Hepatobiliary transport. J HEPATOL 2000;32 (1 Suppl):3-18 [PubMed]
Kullak-Ublick GA, Ismair MG, Kubitz R, Schmitt M, Häussinger D, Stieger B, Hagenbuch B, Meier PJ, Beuers U, Paumgartner G, Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells. CYTOTECHNOLOGY 2000;34 (1-2):1-9 [PubMed]
Poupon RE, Bonnand AM, Queneau PE, Trépo C, Zarski JPA, Vetter D, Raabe JJ, Thieffin G, Larrey D, Grangé JD, Capron JP, Serfaty L, Chrétien Y, St Marc Girardin MF, Mathiex-Fortunet H, Zafrani ES, Guéchot J, Beuers U, Paumgartner G, Poupon R, Randomized trial of interferon-alpha plus ursodeoxycholic acid versus interferon plus placebo in patients with chronic hepatitis C resistant to interferon. SCAND J GASTROENTERO 2000;35 (6):642-649 [PubMed]
Rust C, Rau H, Gerbes AL, Pape GR, Haller M, Krämling H, Schildberg FW, Paumgartner G, Beuers U, Liver transplantation in primary biliary cirrhosis: risk assessment and 11-year follow-up. DIGESTION 2000;62 (1):38-43 [PubMed]
Rust C, Sauter GH, Oswald M, Büttner J, Kullak-Ublick GA, Paumgartner G, Beuers U, Effect of cholestyramine on bile acid pattern and synthesis during administration of ursodeoxycholic acid in man. EUR J CLIN INVEST 2000;30 (2):135-139 [PubMed]
Stangl MJ, Beuers U, Schauer R, Lang T, Gerbes A, Briegel J, Da Silva L, Schildberg FW, Rau HG, Die allogene Lebertransplantation--eine Form der "Gentherapie" bei metabolischen Erkrankungen. Münchener Ergebnisse und Ubersicht. CHIRURG 2000;71 (7):808-819 [PubMed]
Beuers U, Ursodeoxycholic acid after liver transplantation: does conjugation with taurine make the difference?. ITAL J GASTROENTEROL 1999;31 (6):469-471 [PubMed]
Beuers U, Probst I, Soroka C, Boyer JL, Kullak-Ublick GA, Paumgartner G, Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. HEPATOLOGY 1999;29 (2):477-482 [PubMed]
Sackmann M, Beuers U, Helmberger T, Biliary imaging: magnetic resonance cholangiography versus endoscopic retrograde cholangiography. J HEPATOL 1999;30 (2):334-338 [PubMed]
Beuers U, Boyer JL, Paumgartner G, Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications. HEPATOLOGY 1998;28 (6):1449-1453 [PubMed]
Beuers U, Gasser T, Wilson's disease: Molecular basis, clinical manifestations, and rational treatment. MED WELT 1998;49 (3):89-93
Beuers U, Wiedmann KH, Kleber G, Fleig WE, Treatment of autoimmune hepatitis, primarily biliary cirrhosis and primary sclerosing cholangitis - Consensus report of the German Society for Gastrointestinal and Metabolic Disorders (vol 35, pg 1041, 1997). Z GASTROENTEROL 1998;36 (1):113
Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U, Paumgartner G, Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS LETT 1998;424 (3):173-176 [PubMed]
Oswald M, Beuers U, Kullak-Ublick GA, Paumgartner G, 26jähriger Patient mit Oberbauchschmerzen und Cholestase. Primär sklerosierende Cholangitis. INTERNIST 1998;39 (4):398-402 [PubMed]
Rust C, Pratschke E, Hartl W, Kessler M, Weibecke B, Sauerbruch T, Paumgartner G, Beuers U, Fibrotic entrapment of the small bowel in congenital intestinal lymphangiectasia. AM J GASTROENTEROL 1998;93 (10):1980-1983 [PubMed]
von Appen K, Beuers U, Mühlhöfer A, Weiss M, Thoenes GH, Samtleben W, Chronische HIV- und chronische HBV-Infektion mit Erythrozyturie und Proteinurie. DEUT MED WOCHENSCHR 1998;123 (7):185-188 [PubMed]
Beuers U, A view of exocytotic vesicle fusion in living secretory cells. HEPATOLOGY 1997;26 (1):241-243 [PubMed]
Beuers U, Effects of bile acids on hepatocellular signaling and secretion. YALE J BIOL MED 1997;70 (4):341-346 [PubMed]
Beuers U, Heuck A, Iodine accumulation in the liver during long-term treatment with amiodarone. J HEPATOL 1997;26 (2):439 [PubMed]
Beuers U, Wiedmann KH, Kleber G, Fleig WE, Therapie der autoimmunen Hepatitis, primär biliären Zirrhose und primär sklerosierenden Cholangitis. Konsensus der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten. Z GASTROENTEROL 1997;35 (12):1041-1049 [PubMed]
Heuck A, Mattke S, Seemann M, Müller D, Beuers U, Huber A, Reiser M, Erhöhte Leberdichte in der Computertomographie als Folge antiarrhythmischer Therapie mit Amiodaron. ROFO-FORTSCHR RONTG 1997;166 (1):14-17 [PubMed]
Kullak-Ublick GA, Beuers U, Fahney C, Hagenbuch B, Meier PJ, Paumgartner G, Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. HEPATOLOGY 1997;26 (4):991-997 [PubMed]
Kullak-Ublick GA, Glasa J, Böker C, Oswald M, Grützner U, Hagenbuch B, Stieger B, Meier PJ, Beuers U, Kramer W, Wess G, Paumgartner G, Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. GASTROENTEROLOGY 1997;113 (4):1295-1305 [PubMed]
Beuers U, Throckmorton DC, Anderson MS, Isales CM, Thasler W, Kullak-Ublick GA, Sauter G, Koebe HG, Paumgartner G, Boyer JL, Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. GASTROENTEROLOGY 1996;110 (5):1553-1563 [PubMed]
Fischer S, Beuers U, Spengler U, Zwiebel FM, Koebe HG, Hepatic levels of bile acids in end-stage chronic cholestatic liver disease. CLIN CHIM ACTA 1996;251 (2):173-186 [PubMed]
Gülberg V, Waggershauser T, Beuers U, Gerlach JT, Gerbes AL, 46jährige Patientin mit rezidivierender Hämatemesis. INTERNIST 1996;37 (5):515-517 [PubMed]
Helmberger T, Holzknecht N, Gauger J, Beuers U, Reiser M, MRT des Pankreas: Radiologisch-pathologische Korrelation. RADIOLOGE 1996;36 (5):419-426 [PubMed]
Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G, Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization. J HEPATOL 1996;25 (6):985-987 [PubMed]
Kullak-Ublick GA, Beuers U, Paumgartner G, Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells. HEPATOLOGY 1996;23 (5):1053-1060 [PubMed]
Sauter G, Berr F, Beuers U, Fischer S, Paumgartner G, Serum concentrations of 7alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans. HEPATOLOGY 1996;24 (1):123-126 [PubMed]
Beuers U, Gerbes AL, Substitutionstherapie bei primärer biliärer Zirrhose. DEUT MED WOCHENSCHR 1995;120 (37):1259-1260 [PubMed]
Oswald M, Beuers U, Pape GR, Paumgartner G, 23jährige Patientin mit abdominellen Schmerzen, Hepatosplenomegalie, Aszites und Beinödemen. INTERNIST 1995;36 (9):912-917 [PubMed]
Sauter G, Beuers U, Paumgartner G, Effect of dietary fiber on serum bile acids in patients with chronic cholestatic liver disease under ursodeoxycholic acid therapy. DIGESTION 1995;56 (6):523-527 [PubMed]
Beuers U, NATHANSON MH, Boyer JL, Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. GASTROENTEROLOGY 1993;104 (2):604-612 [PubMed]
Beuers U, NATHANSON MH, Isales CM, Boyer JL, Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. J CLIN INVEST 1993;92 (6):2984-2993 [PubMed]
Beuers U, Spengler U, Kruis W, AYDEMIR U, WIEBECKE B, HELDWEIN W, WEINZIERL M, Pape GR, Sauerbruch T, Paumgartner G, Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo-controlled trial. HEPATOLOGY 1992;16 (3):707-714 [PubMed]
Beuers U, Spengler U, Sackmann M, Paumgartner G, Sauerbruch T, Deterioration of cholestasis after endoscopic retrograde cholangiography in advanced primary sclerosing cholangitis. J HEPATOL 1992;15 (1-2):140-143 [PubMed]
Beuers U, Spengler U, Zwiebel FM, PAULETZKI J, Fischer S, Paumgartner G, Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease. HEPATOLOGY 1992;15 (4):603-608 [PubMed]
Beuers U, HEPATIC MALIGNANCIES - CLINICAL-FEATURES AND LABORATORY TESTS. DIAGN ONCOL 1991;1 (6):359-362
Beuers U, Lipoprotein (a) serum levels in chronic cholestatic liver disease during treatment with ursodeoxycholic acid. ARCH INTERN MED 1991;151 (6):1239-1240 [PubMed]
Beuers U, Fischer S, Spengler U, Paumgartner G, Formation of iso-ursodeoxycholic acid during administration of ursodeoxycholic acid in man. J HEPATOL 1991;13 (1):97-103 [PubMed]
Beuers U, Jäger F, Wahlländer A, ANSARI H, KIRSCH CM, Prognostic value of the intravenous 14C-aminopyrine breath test compared to the Child-Pugh score and serum bile acids in 84 cirrhotic patients. DIGESTION 1991;50 (3-4):212-218 [PubMed]
Beuers U, RICHTER WO, RITTER MM, WIEBECKE B, SCHWANDT P, Klinefelter's syndrome and liver adenoma. J CLIN GASTROENTEROL 1991;13 (2):214-216 [PubMed]
Beuers U, Spengler U, Pape GR, Hepatitis after chronic abuse of senna. LANCET 1991;337 (8737):372-373 [PubMed]
Fischer S, Beuers U, Berr F, Paumgartner G, Deoxycholic acid is not reconverted to cholic acid in humans--a study by isotope ratio mass spectrometry. CLIN CHIM ACTA 1991;203 (2-3):269-273 [PubMed]
SCHRAUDOLPH M, RICHTER WO, Permanetter W, RITTER MM, Beuers U, SCHWANDT P, 61jährige Patientin mit Diabetes mellitus, Gewichtsverlust, Ubelkeit und Erbrechen nach Resektion eines Pankreastumors. INTERNIST 1991;32 (4):229-234 [PubMed]
BECKER G, Beuers U, JUNGERMANN K, Modulation by oxygen of the actions of noradrenaline, sympathetic nerve stimulation and prostaglandin F2 alpha on carbohydrate metabolism and hemodynamics in perfused rat liver. BIOL CHEM H-S 1990;371 (10):983-990 [PubMed]
Beuers U, BAUR X, SCHRAUDOLPH M, RICHTER WO, Anaphylactic shock after game of squash in atopic woman with latex allergy. LANCET 1990;335 (8697):1095 [PubMed]
Beuers U, JUNGERMANN K, Relative contribution of glycogenolysis and gluconeogenesis to basal, glucagon- and nerve stimulation-dependent glucose output in the perfused liver from fed and fasted rats. BIOCHEM INT 1990;21 (3):405-415 [PubMed]
Beuers U, RITTER MM, RICHTER WO, Paumgartner G, Lipoprotein (a) serum levels in chronic cholestatic liver disease during treatment with ursodeoxycholic acid. ARCH INTERN MED 1990;150 (7):1542 [PubMed]
Beuers U, Thiel M, BARDENHEUER H, Paumgartner G, Tauroursodeoxycholic acid inhibits the cytosolic Ca++ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine. BIOCHEM BIOPH RES CO 1990;171 (3):1115-1121 [PubMed]
Wahlländer A, Beuers U, Prognosticher Wert von Leberfunktionstests--Klinik, laborchemische Parameter und quantitative Funktionstests. LEBER MAGEN DARM 1990;20 (3):115-6, 119-23, 126-8 [PubMed]
Küster J, Beuers U, JUNGERMANN K, Modulation of the sympathetic nerve action on carbohydrate and ketone body metabolism by fatty acids, glucagon und insulin in perfused rat liver. BIOL CHEM H-S 1989;370 (9):1035-1044 [PubMed]
Spengler U, Beuers U, GOKEL W, Pape GR, Paumgartner G, Chronisch erhöhte Cholestaseparameter und sonographisch echoreiche Leberrundherde bei einem klinisch gesunden Mann. INTERNIST 1989;30 (4):265-268 [PubMed]
Beuers U, Kruis W, DRASCH GA, JACOB K, Pape GR, Paumgartner G, 61jähriger Patient mit seit 15 Monaten zunehmenden diffusen Abdominalschmerzen. INTERNIST 1988;29 (9):648-650 [PubMed]
Beuers U, Kruis W, SCHEURLEN C, Pape GR, MARKL A, ACUTE PANCREATIC PSEUDOCYSTS - CASE-REPORT AND SHORT REVIEW OF LITERATURE. MED WELT 1988;39 (44):1370-1373
Ballé C, Beuers U, ENGELHARDT R, JUNGERMANN K, Intracellular mechanism of action of sympathetic hepatic nerves on glucose and lactate balance in perfused rat liver. EUR J BIOCHEM 1987;170 (1-2):193-199 [PubMed]
BECKH K, Beuers U, ENGELHARDT R, JUNGERMANN K, Mechanism of action of sympathetic hepatic nerves on carbohydrate metabolism in perfused rat liver. BIOL CHEM H-S 1987;368 (4):379-386 [PubMed]
JUNGERMANN K, GARDEMANN A, Beuers U, Ballé C, SANNEMANN J, BECKH K, Hartmann H, Regulation of liver metabolism by the hepatic nerves. ADV ENZYME REGUL 1987;26:63-88 [PubMed]
Beuers U, BECKH K, JUNGERMANN K, Control of ketogenesis in the perfused rat liver by the sympathetic innervation. EUR J BIOCHEM 1986;158 (1):19-24 [PubMed]
Beuers U, POGONKA T, ESTERLINE R, JI S, JUNGERMANN K, Inhibition of para-nitrophenol extraction by stimulation of the hepatic nerves in the perfused rat liver. TOXICOL LETT 1986;34 (2-3):247-252 [PubMed]
Beuers U, HERTTING G, KNEPEL W, Release of beta-lipotropin- and beta-endorphin-like material induced by angiotensin in the conscious rat. BRIT J PHARMACOL 1982;76 (4):579-585 [PubMed]
KNEPEL W, Beuers U, NUTTO D, HERTTING G, Effect of captopril (SQ 14 225) on vasopressin release induced by angiotensin in the conscious rat. CLIN SCI 1982;62 (3):341-342 [PubMed]
Key publications

Maillette de Buy Wenniger LJ, Doorenspleet ME, Klarenbeek PL, Verheij J, Baas F, Elferink RPO, Tak PP, de Vries N, Beuers U, Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis. HEPATOLOGY 2013;57 (6):2390-2398 [PubMed]
Beuers U, Trauner M, Jansen P, Poupon R, New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond. J HEPATOL 2015;62 (1 Suppl):S25-S37 [PubMed]
Kremer AE, van Dijk R, Leckie P, Schaap FG, Kuiper EMM, Mettang T, Reiners KS, Raap U, van Buuren HR, van Erpecum KJ, Davies NA, Rust C, Engert A, Jalan R, Oude Elferink RPJ, Beuers U, Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. HEPATOLOGY 2012;56 (4):1391-1400 [PubMed]
Hohenester S, Wenniger LMDB, Paulusma CC, van Vliet SJ, Jefferson DM, Elferink RPO, Beuers U, A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. HEPATOLOGY 2012;55 (1):173-183 [PubMed]
Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DEJ, Lindor K, Ma X, Mackay IR, Parés A, Tanaka A, Vierling JM, Poupon R, Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'. GASTROENTEROLOGY 2015;149 (6):1627-1629 [PubMed]


All Publications

Curriculum Vitae
Curriculum Vitae

NAME Ulrich Beuers
POSITION TITLE Professor of Gastroenterology and Hepatology; Head, Hepatology; Program Director, Gastroenterology & Hepatology
EDUCATION/TRAINING Physician (MD; University of Freiburg, 1983); Dr.med. (University of Freiburg, 1983); Dr.med.habil./’Privatdozent’ (University of Munich, 1994); Internist (Munich, 1995), Gastroenterologist & Hepatologist (Munich, 1996); Professor, Internal Medicine (University of Munich, 2001); Professor, Gastroenterology & Hepatology (University of Amsterdam, 2007)

A. Positions:

I. Positions and employment

1983 Public medical exam and licence as physician (MD) after studies in Ghent/Belgium (1976-79), Berlin (1979-80) and Freiburg (1980-83).
1983 Dissertation (Dr.med.): “The effect of the renin angiotensin system on release of β-lipotropin and β-endorphin immunoreactivity in the conscious rat“ (Department of Pharmacology, University of Freiburg,”summa cum laude")
1984 - 1986 Postdoctoral fellow, Department of Biochemistry, University of Göttingen
1986 - 1991 Resident, Department of Medicine II, University of Munich
1991 - 1993 Fellow, Liver Center, Yale University School of Medicine, New Haven, CT
1993 - 2002 Fellow (1993-1995), Consultant (1995-2002), Department of Medicine II, University of Munich
1994 Habilitation for Internal Medicine (Dr.med.habil./’Privatdozent’). Title of the thesis: “On clinical effectiveness, metabolism and mechanisms of action of ursodeoxycholic acid in chronic cholestatic liver diseases"
2001 - 2008 Professor, Internal Medicine, University of Munich
2003 - 2006 Senior Consultant, Department of Medicine II, University of Munich
2007 - now Professor, Gastroenterology & Hepatology, Academic Medical Center, University of Amsterdam
2010 - now Program Director, Gastroenterology & Hepatology, Academic Medical Center, University of Amsterdam
2011 - now Head, Hepatology, Academic Medical Center, University of Amsterdam

II. Other relevant experience and professional memberships

● Chairman, Netherlands Society of Hepatology / Netherlands Association for the Study of the Liver (2012-       )
● Chairman, Netherlands Education Committee Gastroenterology & Hepatology (2014-       )
● Chairman, EASL Clinical Practice Guidelines “Management of cholestatic liver diseases” (2008-        )
● Associate Editor: Journal of Hepatology (2014-2019, 2000-2004, 1997-2000 [Assist.E.]), Neth J Med (2009-2013)
● Editorial Boards: Hepatology (since 2007), Gut (since 2009), Journal of Hepatology (since 2005), Digestive and Liver Diseases (since 2009), European Journal of Gastroenterology and Hepatology (since 2009), Gastroenterologie Clinique et Biologique (since 2010), World J Gastroenterol (since 2007).

● Member of selection committees: EASL, AASLD, APASL, NVGE/NVH, DGVS; AASLD Steering Board “Cholestasis” (2008-2012)

● Professional Memberships:
European Association for the Study of the Liver (EASL)
American Association for the Study of Liver Diseases (AASLD)
Netherlands Association for the Study of the Liver (NVH)
Netherlands Association for Gastroenterology (NVGE)
Netherlands Association for Gastroenterology & Hepatology (NVMDL)
Deutsche Gesellschaft für Innere Medizin (DGIM)
Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS)
Deutsche Arbeitsgemeinschaft zum Studium der Leber (GASL)

III. Honors and awards
2010 Honorary member, Czechian Society of Hepatology
2005 Honorary member, Slovakian Society of Medicine, Section of Hepatology
1994 German Association for the Study of the Liver Award for the paper “Tauroursodeoxycholic acid translocates alpha-protein kinase C in isolated rat hepatocytes“ (Gastroenterology 1996;110:1553-63)
1994 Adolf-Kußmaul Award, Southwest-German Society of Gastroenterology, for the paper “Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++, mechanisms defective in cholestasis“ (J Clin Invest 1993;92:2984-2993)
1984 Fritz-Külz Award, German Pharmacological Society, for the dissertation “The effect of the renin angiotensin system on release of β-lipotropin and β-endorphin immunoreactivity in the conscious rat“ (Brit J Pharmacol 1982;76:579-585)

B. Selection of peer-reviewed publications:

I. Selection of eight most contributing publications 2010-2014

1: Beuers U, Kremer AE, Bolier R, OudeElferink RP. Pruritus in cholestasis – facts and fictions. Hepatology 2014;59:in press

2: Maillette de Buy Wenniger LJ, Curver EL, Beuers U. Exposure to occupational antigens might predispose to IgG4-related disease. Hepatology 2014;59:epub ahead of print

3: Maillette de Buy Wenniger LJ, Doorenspleet ME, Klarenbeek PL, Verheij J, Baas F, OudeElferink RP, Tak PP, de Vries N, Beuers U. Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis. Hepatology 2013;57:2390-8.

4: Kremer AE, van Dijk R, Leckie P, Schaap FG, Kuiper EM, Mettang T, Reiners KS, Raap U, van Buuren HR, van Erpecum KJ, Davies NA, Rust C, Engert A, Jalan R, OudeElferink RP, Beuers U. Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. Hepatology 2012;56:1391-400.

5: Hohenester S, Maillette de Buy Wenniger LM, Paulusma CC, van Vliet SJ, Jefferson DM, OudeElferink RP, Beuers U. A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology 2012; 55:173-83.

6: Denk GU, Maitz S, Wimmer R, Rust C, Invernizzi P, Ferdinandusse S, Kulik W, Fuchsbichler A, Fickert P, Trauner M, Hofmann AF, Beuers U. Conjugation is essential for the anticholestatic effect of norursodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver. Hepatology 2010;52:1758-68.

7: Beuers U, Hohenester S, Maillette de Buy Wenniger L, Kremer AE, Jansen PLM, OudeElferink RPJ. The biliary HCO3- umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology 2010;52:1489-1496.

8: Kremer AE, Martens J, Kulik W, Ruëff F, Kuiper EMM, van Buren HR, van Erpecum KJ, Kondrackiene J, Prieto J, Rust C, Geenes VL, Williamson C, Moolenaar WH, Beuers U, OudeElferink RPJ. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology 2010;139:1008-1018.

II. Median impact factor of publications: 9.86
(total 327 publications [ISI web of knowledge 03-01-2014], average citations per item: 15.7; h-index 39)

III. Median impact factors for the own field(s): 2.2 (ISI web of knowledge category Gastroenterology & Hepatology)

IV. The top 3 leading Journals in the own field are Gastroenterology: IF 12.8; Hepatology: IF 12.0; Gut: IF 10.7

V. Patents: pending (European Patent Agency, method for diagnosing IgG4 related diseases, originally applied
30/9/2012 under application number EP 12 18 6746)
Research programmes

Pathogenetic and therapeutic aspects of chronic cholestatic liver diseases

The biliary bicarbonate umbrella: We hypothesized that biliary bicarbonate secretion is essential for protection of human biliary epithelia against uncontrolled influx of nonpolarized glycine-conjugated bile acids (Beuers et al., Hepatology 2010; Hohenester et al. Hepatology 2012). Genetic polymorphisms may contribute to weakening of the biliary bicarbonate umbrella leading to chronic cholangiopathies like primary biliary cirrhosis, primary sclerosing cholangitis, cystic fibrosis-associated liver disease or posttransplant biliary strictures. Pharmacological stabilization of the bicarbonate umbrella with bile salts (e.g., ursodeoxycholate, norursodeoxycholate) or nuclear receptor agonists (e.g., obeticholate) represents a potential therapeutic strategy for these disorders.

Itch in cholestasis: Itch is a major burden for patients with cholestatic disorders. Its pathogenesis is unknown. We recently identified autotaxin (ATX) and its product, lysophosphatidic acid (LPA), a pruritogen in rodents, in serum of patients with cholestatic itch at higher concentrations than in controls and found a striking association with itch intensity (Kremer et al., Gastroenterology 2010) and treatment response (Kremer et al., Hepatology 2012). We also found that the most potent antipruritic agent, the pregnane-X receptor (PXR) agonist rifampicine, impairs ATX expression by PXR-dependent mechanisms possibly explaining its beneficial effect in patients at least in part (Kremer, van Dijk et al. Hepatology 2012). Further understanding of the role of ATX/LPA in cholestatic itch may allow development of novel therapeutic strategies for management of itch (for review: Beuers et al. Hepatology 2014, epub).

IgG4-associated cholangitis (IAC) and IgG4-related systemic disease: IAC is a recently defined autoimmune bile duct disorder which is often associated with autoimmune pancreatitis or other systemic manifestations of IgG4-related systemic disease. IAC has a good prognosis when adequately diagnosed and treated. The pathogenesis of this corticosteroid-responsive disorder is completely unknown. In clinical practice, it is challenging to differentiate IAC, cholangiocarcinoma (CCA) or primary sclerosing cholangitis (PSC) as these disorders may show comparable features in serum biochemistry and cholangiography. Bile duct cytology / histology is often of limited reliability for the diagnosis. IgG4 serum levels may be elevated in all these disorders. We recently succeeded by use of a novel next generation sequencing technique in unraveling highly abundant IgG4+ B cell receptor (BCR) clones in blood and tissue of patients with active IAC (but not PSC or CCA), which disappear upon corticosteroid treatment (Maillette de Buy Wenniger, Doorenspleet et al. Hepatology 2013). Our data strongly suggest that specific B cell responses are pivotal to the pathogenesis of IAC. In support of our concept, we most recently identified "blue collar work" as a potential risk factor for development of IgG4-related disease in two independent cohorts of patients with IgG4-related systemic disease (Maillette de Buy Wenniger, Curver, Beuers, Hepatology 2014, epub). Our next aims are to define the antigens against which IgG4 are directed in IAC and to better understand the pathophysiological role of IgG4 in IgG4-related systemic disease.

Severe persistent hepatocellular secretory failure (PHSF): We recently identified the pregnane X receptor (PXR) agonist rifampicin as a potent drug to effectively treat severe persistent hepatocellular secretory failure, a rare disorder induced by drugs, toxins or transient bile duct obstruction and associated with severe progressive jaundice (bilrubine > 255 umol/l) after removal of the trigger. We try to elucidate the molecular mechanisms involved in PHSF and its reversal induced by the PXR agonist rifampicin (van Dijk et al. submitted).

Clinical therapeutic trials 2014:

- Obeticholate in primary biliary cirrhosis,

- Budesonide in primary biliary cirrhosis,

- Norursodeoxycholate in primary sclerosing cholangitis,

- Diagnosis and treatment of IgG4-associated cholangitis,

- Rifampicin in severe persistent hepatocellular secretory failure,

- A PPAR alpha/delta agonist in nonalcoholic steatohepatitis (NASH)

Faculty
Prof. dr. U.H.W. Beuers
Dr. K.F.J. van de Graaf

Postdocs
Dr. L. Maroni MD

PhD Students
S.J. Aronson
J.-C. Chang MSc
H.W. Chen
R. van Dijk
Drs. R. Erken MD
T. Herta
Drs. S. Hohenester MD
Drs. L.M. Hubers
J.A.G.M. Langedijk
K.N. van Munster
Drs. J.B. van Niekerk
Drs. R.L.P. Roscam Abbing
Drs. D. Slijepcevic
W.L. Smit
S.B. Willemse
J.J. Witjes
K. de Wit MD

Others
W.D. Tolenaars

Other research related activities
  • Membership of editorial board / Editorship, JOURNAL OF HEPATOLOGY
  • Membership of editorial board / Editorship, HEPATOLOGY
  • Membership of editorial board / Editorship, GUT
  • Membership of editorial board / Editorship, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Membership of editorial board / Editorship, DIGESTIVE AND LIVER DISEASE
  • Membership of editorial board / Editorship, GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE
  • Membership of editorial board / Editorship, WORLD JOURNAL OF GASTROENTEROLOGY
  • Membership of advisory board / Consultant, Intercept, San Diego
  • Membership of advisory board / Consultant, Novartis BV
  • Contribution to guidelines and protocols, EASL Clinical Practice Guidelines "Management of cholestatic liver diseases"
Current research funding
  • Accelsiors Ltd.
  • Covance CAPS Ltd.
  • CRO at Covance Caps Ltd.
  • Dr. Falk Pharma GmbH
  • ENYO Pharma SA
  • Europese Unie
  • Gilead Sciences, Inc.
  • Gilead Sciences Netherlands B.V. NL815897996B01
  • Hogeschool Leiden, Cluster Zorg
  • Intercept Pharmaceuticals Inc.
  • Maag-Darm Stichting
  • Medical Research BV
  • Merck Sharp & Dohme BV
  • Pharmaceutical Research associates, Group BV
  • PPD Global Ltd
  • PPD Netherlands BV
  • Stichting AMC Foundation (Vrijgesteld)
  • Stichting Gastrostart