• Principal Investigator
  • Male

Prof. dr. D.L.P. Baeten

Position:
Main activities: Research
Specialisation:
foto D.L.P. Baeten is one of the AMC Principal Investigators
Focus of research:

Immunopathology of chronic inflammatory arthritis

AMC themes: Infection & Immunity
Departments: Internal Medicine: Clinical Immunology and Rheumatology
Angiolilli C. Molecular mechanisms of histone deacetylases in rheumatoid arthritis fibroblast-like synoviocytes. S.l.: s.n.; 2017. 159p. ISBN 978-94-6182-756-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Baeten DLP; copromotor(s): Reedquist KA)
Angiolilli C, Baeten DL, Radstake TR, Reedquist KA, The acetyl code in rheumatoid arthritis and other rheumatic diseases. EPIGENOMICS-UK 2017;9 (4):447-461 [PubMed]
Angiolilli C, Kabala PA, Grabiec AM, van Baarsen IM, Ferguson BS, García S, Malvar Fernandez B, McKinsey TA, Tak PP, Fossati G, Mascagni P, Baeten DL, Reedquist KA, Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes. ANN RHEUM DIS 2017;76 (1):277-285 [PubMed]
Braun J, Baraliakos X, Deodhar A, Baeten D, Sieper J, Emery P, Readie A, Martin R, Mpofu S, Richards HB, Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study. ANN RHEUM DIS 2017;76 (6):1070-1077 [PubMed]
de Winter J, van de Sande M, Landewe R, Baeten D, Bone marrow edema in the sacroiliac joint-degenerative sacroiliac joint disease might be more likely than spondyloarthritis: comment on the article by Turina et al Reply. ARTHRITIS RHEUMATOL 2017;69 (5):1124-1125 [PubMed]
Kabala PA, Angiolilli C, Yeremenko N, Grabiec AM, Giovannone B, Pots D, Radstake TR, Baeten D, Reedquist KA, Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes. ARTHRITIS RES THER 2017;19 (1):207 [PubMed]
Levels MJ, van Tok MN, Cantaert T, Cañete JD, Kroese FGM, Germar K, Spits H, Baeten DLP , Yeremenko NG, The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation. ARTHRITIS RHEUMATOL 2017;69 (4):750-762 [PubMed]
Noordenbos T. The role of innate immune cells in tissue inflammation in spondyloarthritis. S.l.: s.n.; 2017. 197p. ISBN 978-94-6182-743-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Baeten DLP; copromotor(s): Yeremenko NG)
Turina MC, Landewé R, Baeten D, Lessons to be learned from serum biomarkers in psoriasis and IBD - the potential role in SpA. EXPERT REV CLIN IMMU 2017;13 (4):333-344 [PubMed]
Turina MC, Yeremenko N, van Gaalen F, van Oosterhout M, Berg IJ, Ramonda R, Lebre CMC, Landewé R, Baeten D, Serum inflammatory biomarkers fail to identify early axial spondyloarthritis: results from the SpondyloArthritis Caught Early (SPACE) cohort. RMD OPEN 2017;3 (1):e000319 [PubMed]
van den Brandt S, Zbinden A, Baeten D, Villiger PM, Østensen M, Förger F, Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients. ARTHRITIS RES THER 2017;19 (1):64 [PubMed]
van Mens LJJ, Turina MC, van de Sande MGH, Nurmohamed MT, van Kuijk AWR, Baeten DLP, Residual disease activity in psoriatic arthritis: discordance between the rheumatologist's opinion and minimal disease activity measurement. RHEUMATOLOGY 2017;ahead of print [PubMed]
van Mens LJJ, van de Sande MGH, Baeten DLP, Comment on: Residual disease activity in psoriatic arthritis: discordance between the rheumatologist's opinion and minimal disease activity measurement: reply. RHEUMATOLOGY 2017;ahead of print [PubMed]
van Mens LJJ, van de Sande MGH, Baeten DLP, New treatment paradigms in spondyloarthritis. CURR OPIN RHEUMATOL 2017;ahead of print [PubMed]
van Mens LJJ, van de Sande MGH, Fluri IA, Atiqi S, van Kuijk AWR, Baeten DLP, Residual disease activity and treatment adjustments in psoriatic arthritis in current clinical practice. ARTHRITIS RES THER 2017;19 (1):226 [PubMed]
van Mens LJJ, van de Sande MGH, van Kuijk AWR, Baeten D, Coates LC, Ideal target for psoriatic arthritis? Comparison of remission and low disease activity states in a real-life cohort. ANN RHEUM DIS 2017;ahead of print [PubMed]
van Tok MN, Satumtira N, Dorris M, Pots D, Slobodin G, van de Sande MG, Taurog JD, Baeten DL, van Duivenvoorde LM, Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats. FRONT IMMUNOL 2017;8:920 [PubMed]
Wei JCC, Baeten D, Sieper J, Deodhar A, Bhosekar V, Martin R, Porter B, Efficacy and safety of secukinumab in Asian patients with active ankylosing spondylitis: 52-week pooled results from two phase 3 studies. INT J RHEUM DIS 2017;20 (5):589-596 [PubMed]
Angiolilli C, Grabiec AM, Ferguson BS, Ospelt C, Malvar Fernandez B, van Es IE, van Baarsen LGM, Gay S, McKinsey TA, Tak PP, Baeten DL, Reedquist KA, Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression. ANN RHEUM DIS 2016;75 (2):430-438 [PubMed]
Bernelot Moens SJ, van Leuven SI, Zheng KH, Havik SR, Versloot MV, van Duivenvoorde LM, Hahne M, Stroes ESG, Baeten DL, Hamers AAJ, Impact of the B Cell Growth Factor APRIL on the Qualitative and Immunological Characteristics of Atherosclerotic Plaques. PLOS ONE 2016;11 (11):e0164690 [PubMed]
Ciccia F, Guggino G, Ferrante A, Raimondo S, Bignone R, Rodolico V, Peralta S, van Tok M, Cannizzaro A, Schinocca C, Ruscitti P, Cipriani P, Giacomelli R, Alessandro R, Dieli F, Rizzo A, Baeten D, Triolo G, Interleukin-9 Overexpression and Th9 Polarization Characterize the Inflamed Gut, the Synovial Tissue, and the Peripheral Blood of Patients With Psoriatic Arthritis. ARTHRITIS RHEUMATOL 2016;68 (8):1922-1931 [PubMed]
Deodhar AA, Dougados M, Baeten DL, Cheng-Chung Wei J, Geusens P, Readie A, Richards HB, Martin R, Porter B, Effect of Secukinumab on Patient-Reported Outcomes in Patients With Active Ankylosing Spondylitis A Phase III Randomized Trial (MEASURE 1). ARTHRITIS RHEUMATOL 2016;68 (12):2901-2910 [PubMed]
de Winter JJ, van Mens LJ, van der Heijde D, Landewé R, Baeten DL, Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis. ARTHRITIS RES THER 2016;18:196 [PubMed]
Hua C, Audo R, Yeremenko N, Baeten D, Hahne M, Combe B, Morel J, Daïen C, A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells. J AUTOIMMUN 2016;73:64-72 [PubMed]
Kerkman PF, Fabre E, van der Voort EIH, Zaldumbide A, Rombouts Y, Rispens T, Wolbink G, Hoeben RC, Spits H, Baeten DLP , Huizinga TWJ, Toes REM, Scherer HU, Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis. ANN RHEUM DIS 2016;75 (6):1170-1176 [PubMed]
Kuijpers TW, Vendelbosch S, Berg Mvd, Baeten DLP, Killer immunoglobulin receptor genes in spondyloarthritis. CURR OPIN RHEUMATOL 2016;28 (4):368-375 [PubMed]
Malysheva K, de Rooij K, Lowik CW, Baeten DL, Rose-John S, Stoika R, Korchynskyi O, Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts. CROAT MED J 2016;57 (2):89-98 [PubMed]
Noordenbos T, Blijdorp I, Chen S, Stap J, Mul E, Cañete JD, Lubberts E, Yeremenko N, Baeten D, Human mast cells capture, store, and release bioactive, exogenous IL-17A. J LEUKOCYTE BIOL 2016;100 (3):453-462 [PubMed]
Paramarta JE, Turina MC, Noordenbos T, Heijda TF, Blijdorp IC, Yeremenko N, Baeten D, A proof-of-concept study with the tyrosine kinase inhibitor nilotinib in spondyloarthritis. J TRANSL MED 2016;14 (1):308 [PubMed]
Rekers NV, Bajema IM, Mallat MJK, Petersen B, Anholts JDH, Swings GMJS, van Miert PPMC, Kerkhoff C, Roth J, Popp D, van Groningen MC, Baeten D, Goemaere N, Kraaij MD, Zandbergen M, Heidt S, van Kooten C, de Fijter JW, Claas FHJ, Eikmans M, Beneficial Immune Effects of Myeloid-Related Proteins in Kidney Transplant Rejection. AM J TRANSPLANT 2016;16 (5):1441-1455 [PubMed]
Rysnik O, McHugh K, van Duivenvoorde L, van Tok M, Guggino G, Taurog J, Kollnberger S, Ciccia F, Baeten D, Bowness P, Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue. J AUTOIMMUN 2016;70:12-21 [PubMed]
Rysnik O, McHugh K, van Duivenvoorde L, van Tok M, Taurog J, Kollnberger S, Baeten D, Bowness P, Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue. DATA BRIEF 2016;9:100-111 [PubMed]
Tas SW, Baeten DLP, Recent Advances in the Treatment of Immune-Mediated Inflammatory Diseases. METHODS MOL BIOL 2016;1371:143-155 [PubMed]
Turina MC. Towards new measures of inflammation in spondyloarthritis. S.l.: s.n.; 2016. 153p. ISBN 978-94-6233-234-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Baeten DLP, Landewé RBM; copromotor(s): )
Turina MC, de Winter JJ, Paramarta JE, Gamala M, Yeremenko N, Nabibux MN, Landewé R, Baeten DL, Clinical and Imaging Signs of Spondyloarthritis in First-Degree Relatives of HLA-B27-Positive Ankylosing Spondylitis Patients: The Pre-Spondyloarthritis (Pre-SpA) Cohort Study. ARTHRITIS RHEUMATOL 2016;68 (10):2444-2455 [PubMed]
Turina MC, Ramiro S, Baeten DL, Mease P, Paramarta JE, Song IH, Pangan AL, Landewé R, A psychometric analysis of outcome measures in peripheral spondyloarthritis. ANN RHEUM DIS 2016;75 (7):1302-1307 [PubMed]
van der Valk FM, Bernelot Moens SJ, Verweij SL, Strang AC, Nederveen AJ, Verberne HJ, Nurmohamed MT, Baeten DL, Stroes ESG, Increased arterial wall inflammation in patients with ankylosing spondylitis is reduced by statin therapy. ANN RHEUM DIS 2016;75 (10):1848-1851 [PubMed]
van de Sande MG, Baeten DL, Immunopathology of synovitis: from histology to molecular pathways. RHEUMATOLOGY 2016;55 (4):599-606 [PubMed]
van Tok MN, Yeremenko NG, Teitsma CA, Kream BE, Knaup VL, Lories RJ, Baeten DL, van Duivenvoorde LM, Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis. PLOS ONE 2016;11 (10):e0163632 [PubMed]
Baeten D. Etiology, pathogenesis and pathophysiology of ankylosing spondylitis in: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology (6th ed). Philadelphia: Elsevier Mosby; 2015. 2, p. 951-955
Baeten D, Sieper J, Braun J, Baraliakos X, Dougados M, Emery P, Deodhar A, Porter B, Martin R, Andersson M, Mpofu S, Richards HB [Contributors: van den Bosch F, Nzeusseu A, de Vlam K, Geusens P, Oparanov B, Rashkov R, Batalov A, Goranov I, Kazmin I, McCarthy T, Inman R, Rahman P, Schaeverbeke T, N'Guyen M, Bertin P, Frediani B, Adami S, Foti R, Triolo G, Fusaro E, Franceschini F, Zazueta B, Maradiaga M, Avila H, Garza M, Baeten D, Bijlsma H, Berrocal A, Garro B, Gamboa R, Castaneda O, Becerra F, Stanislav M, Salnikova T, Maslyanskiy A, Ershova O, Izmozherova N, Lesniak O, Tseng JC, Wei CC, Ozdogan H, Kisacik B, Onen F, Tahir H, Ostor A, Barkham N, Kay L, Braun J, Dahmen G, Rubbert-Roth A, Wassenberg S, Oelzner P, Nuesslein H, Moericke R, Rech J, Sieper J, Deodhar A, Kivitz A, Aelion J, Kohen M, Knibbe W, LaSalle S, Zang S, Cohen S, Brooks M, Graninger W, Jorg R, Zamani O, Bessette L, Cohen M, Beaulieu A, Pavelka K, Galatikova D, Dokoupilova E, Leirisalo-Repo M, Paimela L, Järvinen P, Sokka-Isler T, Rouhe E, keskussairaala S, Pellerito R, Bijlsma J, Trofimov V, Vezikova N, Zotkin E, Mosesova N, Lee LN, Cheung P, Balsa A, Blanco R, Blanco FJ, Gonzalez C, Bannert B, Daniela B, Dudler J, Ciurea A, Marzo-Ortega H, Gaffney K, Mackay K, Codding C, Dorman W, Legerton C 3rd, Khan M, Lee E, Caldron P, Wolfe JF, Swarup A, Singhal A, Tony HP]] , Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis. NEW ENGL J MED 2015;373 (26):2534-2548 [PubMed]
Cañete JD, Celis R, Yeremenko N, Sanmartí R, van Duivenvoorde L, Ramírez J, Blijdorp I, García-Herrero CM, Pablos JL, Baeten DL, Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis. ARTHRITIS RES THER 2015;17:173 [PubMed]
Musters A, Tak PP, Baeten DLP , Tas SW, Anti-interleukin 6 receptor therapy for hyper-IgD syndrome. BMJ CASE REP 2015;2015:bcr2015210513 [PubMed]
Vieira-Sousa E, van Duivenvoorde LM, Fonseca JE, Lories RJ, Baeten DL, Review: animal models as a tool to dissect pivotal pathways driving spondyloarthritis. ARTHRITIS RHEUMATOL 2015;67 (11):2813-2827 [PubMed]
Vogelpoel LTC, Baeten DLP , de Jong EC, den Dunnen J, Control of cytokine production by human Fc gamma receptors: implications for pathogen defense and autoimmunity. FRONT IMMUNOL 2015;6:79 [PubMed]
Wixler V, Cromme C, Retser E, Meyer LH, Smyth N, Mühlenberg K, Korb-Pap A, Koers-Wunrau C, Sotsios Y, Bassel-Duby R, Baeten D, Tak PP, Niederreiter B, Redlich K, Bertrand J, Skryabin BV, Ludwig S, Pap T, FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis. ANN RHEUM DIS 2015;74 (12):2216-2223 [PubMed]
Yeremenko N, Zwerina K, Rigter G, Pots D, Fonseca JE, Zwerina J, Schett G, Baeten D, Tumor necrosis factor and interleukin-6 differentially regulate Dkk-1 in the inflamed arthritic joint. ARTHRITIS RHEUMATOL 2015;67 (8):2071-2075 [PubMed]
Baeten D, Hueber W, Secukinumab for ankylosing spondylitis Authors' reply. LANCET 2014;383 (9919):780-781 [PubMed]
Duroux-Richard I, Pers YM, Fabre S, Ammari M, Baeten D, Cartron G, Touitou I, Jorgensen C, Apparailly F, Circulating miRNA-125b is a potential biomarker predicting response to rituximab in rheumatoid arthritis. MEDIAT INFLAMM 2014;2014:342524 [PubMed]
Evans HG, Roostalu U, Walter GJ, Gullick NJ, Frederiksen KS, Roberts CA, Sumner J, Baeten DL, Gerwien JG, Cope AP, Geissmann F, Kirkham BW, Taams LS, TNF-α blockade induces IL-10 expression in human CD4+ T cells. NAT COMMUN 2014;5:3199 [PubMed]
García S, Krausz S, Ambarus CA, Fernández BM, Hartkamp LM, van Es IE, Hamann J, Baeten DL, Tak PP, Reedquist KA, Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype. PLOS ONE 2014;9 (1):e82088 [PubMed]
Holzinger D, Nippe N, Vogl T, Marketon K, Mysore V, Weinhage T, Dalbeth N, Pool B, Merriman T, Baeten D, Ives A, Busso N, Foell D, Bas S, Gabay C, Roth J, Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout. ARTHRITIS RHEUMATOL 2014;66 (5):1327-1339 [PubMed]
Hreggvidsdottir HS, Noordenbos T, Baeten DL, Inflammatory pathways in spondyloarthritis. MOL IMMUNOL 2014;57 (1):28-37 [PubMed]
Kroese FGM, Baeten D, Huizinga TWJ, Autoimmunity: break-through in the diagnosis and treatment of immune-mediated inflammatory diseases. IMMUNOL LETT 2014;162 (2 Part B):150-162 [PubMed]
Martin JC, Baeten DL, Josien R, Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus. CLIN IMMUNOL 2014;154 (1):1-12 [PubMed]
Paramarta JE. Spondyloarthritis: From disease phenotypes to novel treatments. S.l.: s.n.; 2014. 211p. ISBN 9789461824714 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Baeten DLP, Tak PP; copromotor(s): )
Paramarta JE, Baeten D, Response to: 'paying attention to enthesitis in early untreated arthritis: MRI for the evaluation of enthesitis', by Zhou et al. ANN RHEUM DIS 2014;73 (10):e61 [PubMed]
Paramarta JE, Baeten D, Spondyloarthritis: from unifying concepts to improved treatment. RHEUMATOLOGY 2014;53 (9):1547-1559 [PubMed]
Paramarta JE, Baeten DL, Adalimumab serum levels and antidrug antibodies towards adalimumab in peripheral spondyloarthritis: no association with clinical response to treatment or with disease relapse upon treatment discontinuation. ARTHRITIS RES THER 2014;16 (4):R160 [PubMed]
Paramarta JE, van der Leij C, Gofita I, Yeremenko N, van de Sande MG, de Hair MJ, Tak PP, Maas M, Baeten D, Peripheral joint inflammation in early onset spondyloarthritis is not specifically related to enthesitis. ANN RHEUM DIS 2014;73 (4):735-740 [PubMed]
Teunissen MBM, Yeremenko NG, Baeten DLP , Chielie S, Spuls PI, de Rie MA, Lantz O, Res PCM, The IL-17A-producing CD8+ T-cell population in psoriatic lesional skin comprises mucosa-associated invariant T cells and conventional T cells. J INVEST DERMATOL 2014;134 (12):2898-2907 [PubMed]
Turina MC, Sieper J, Yeremenko N, Conrad K, Haibel H, Rudwaleit M, Baeten D, Poddubnyy D, Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis. ANN RHEUM DIS 2014;73 (9):1746-1748 [PubMed]
Turina MC, Yeremenko N, Paramarta JE, de Rycke L, Baeten D, Calprotectin (S100A8/9) as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis. ARTHRITIS RES THER 2014;16 (4):413 [PubMed]
van Duivenvoorde L, Baeten D, Comment on: 'Spondyloarthritis: may the force be with you?', the Editorial by McGonagle et al. ANN RHEUM DIS 2014;73 (7):e38 [PubMed]
Vogelpoel LTC, Hansen IS, Rispens T, Muller FJM, van Capel TMM, Turina MC, Vos JB, Baeten DLP , Kapsenberg ML, de Jong EC, den Dunnen J, Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages. NAT COMMUN 2014;5:5444 [PubMed]
Yeremenko N, Härle P, Cantaert T, van Tok M, van Duivenvoorde LM, Bosserhoff A, Baeten D, The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis. RHEUMATOLOGY 2014;53 (3):438-447 [PubMed]
Yeremenko N, Paramarta JE, Baeten D, The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis. CURR OPIN RHEUMATOL 2014;26 (4):361-370 [PubMed]
Yoshida K, Korchynskyi O, Tak PP, Isozaki T, Ruth JH, Campbell PL, Baeten DL, Gerlag DM, Amin MA, Koch AE, Citrullination of Epithelial Neutrophil-Activating Peptide 78/CXCL5 Results in Conversion From a Non-Monocyte-Recruiting Chemokine to a Monocyte-Recruiting Chemokine. ARTHRITIS RHEUMATOL 2014;66 (10):2716-2727 [PubMed]
Baeten D, Ontsteking en structurele orgaanschade: kip of ei?. NED TIJDSCHR GENEESKD 2013;157 (38):A6532 [PubMed]
Baeten D, Baraliakos X, Braun J, Sieper J, Emery P, van der Heijde D, McInnes I, van Laar JM, Landewé R, Wordsworth P, Wollenhaupt J, Kellner H, Paramarta J, Wei J, Brachat A, Bek S, Laurent D, Li Y, Wang YA, Bertolino AP, Gsteiger S, Wright AM, Hueber W, Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. LANCET 2013;382 (9906):1705-1713 [PubMed]
Baeten D, Breban M, Lories R, Schett G, Sieper J, Are spondylarthritides related but distinct conditions or a single disease with a heterogeneous phenotype?. ARTHRITIS RHEUM-US 2013;65 (1):12-20 [PubMed]
Baeten DLP , Kuchroo VK, How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases. NAT MED 2013;19 (7):824-825 [PubMed]
Cantaert T, Teitsma C, Tak PP, Baeten D, Presence and role of anti-citrullinated protein antibodies in experimental arthritis models. ARTHRITIS RHEUM-US 2013;65 (4):939-948 [PubMed]
Cantaert T, Yeremenko NG, Teitsma CA, van Duivenvoorde LM, Paramarta JE, Tak PP, Baeten DL, Altered BANK1 expression is not associated with humoral autoimmunity in chronic joint inflammation. RHEUMATOLOGY 2013;52 (2):252-260 [PubMed]
de Rooy DPC, Yeremenko NG, Wilson AG, Knevel R, Lindqvist E, Saxne T, Krabben A, Leijsma MK, Daha NA, Tsonaka S, Zhernakova A, Houwing-Duistermaat JJ, Huizinga TWJ, Toes REM, Baeten DLP , Brouwer E, van der Helm-van Mil AHM, Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. ANN RHEUM DIS 2013;72 (5):769-775 [PubMed]
Fernandez L, Salinas GF, Rocha C, Carvalho-Pinto CE, Yeremenko N, Papon L, Medema JP, Combe B, Morel J, Baeten D, Hahne M, The TNF family member APRIL dampens collagen-induced arthritis. ANN RHEUM DIS 2013;72 (8):1367-1374 [PubMed]
Francosalinas G, Cantaert T, Nolte MA, Tak PP, van Lier RAW, Baeten DL, Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice. J NEUROIMMUNOL 2013;255 (1-2):8-17 [PubMed]
Frey S, Derer A, Messbacher ME, Baeten DLP , Bugatti S, Montecucco C, Schett G, Hueber AJ, The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium. ANN RHEUM DIS 2013;72 (9):1569-1574 [PubMed]
Musters A, Assaf A, Baeten DLP , Tas SW, Off-labelgebruik van biologicals voor zeldzame immunologische aandoeningen. NED TIJDSCHR GENEESKD 2013;157 (49):A6419 [PubMed]
Paramarta JE, de Rycke L, Ambarus CA, Tak PP, Baeten D, Undifferentiated spondyloarthritis vs ankylosing spondylitis and psoriatic arthritis: a real-life prospective cohort study of clinical presentation and response to treatment. RHEUMATOLOGY 2013;52 (10):1873-1878 [PubMed]
Paramarta JE, de Rycke L, Heijda TF, Ambarus CA, Vos K, Dinant HJ, Tak PP, Baeten DL, Efficacy and safety of adalimumab for the treatment of peripheral arthritis in spondyloarthritis patients without ankylosing spondylitis or psoriatic arthritis. ANN RHEUM DIS 2013;72 (11):1793-1799 [PubMed]
Paramarta JE, Heijda TF, Baeten DL, Fast relapse upon discontinuation of tumour necrosis factor blocking therapy in patients with peripheral spondyloarthritis. ANN RHEUM DIS 2013;72 (9):1581-1582 [PubMed]
Popadic D, Anegon I, Baeten D, Eibel H, Giese T, Marits P, Martinez-Caceres E, Mascart F, Nestle F, Pujol-Borrell R, Savic E, Scheibenbogen C, Seliger B, Thunberg S, Turina M , Villanova F, Winqvist O, Wikström AC, Predictive immunomonitoring -- the COST ENTIRE initiative. CLIN IMMUNOL 2013;147 (1):23-26 [PubMed]
Salinas GF, Braza F, Brouard S, Tak PP, Baeten D, The role of B lymphocytes in the progression from autoimmunity to autoimmune disease. CLIN IMMUNOL 2013;146 (1):34-45 [PubMed]
Salinas GF, de Rycke L, Barendregt B, Paramarta JE, Hreggvidstdottir H, Cantaert T, van der Burg M, Tak PP, Baeten D, Anti-TNF treatment blocks the induction of T cell-dependent humoral responses. ANN RHEUM DIS 2013;72 (6):1037-1043 [PubMed]
Yeremenko N, Noordenbos T, Cantaert T, van Tok M, van de Sande M, Cañete JD, Tak PP, Baeten D, Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis. ARTHRITIS RHEUM-US 2013;65 (1):174-185 [PubMed]
Ambarus CA. Macrophage polarization in spondyloarthritis. s.l.: s.n.; 2012. 186p. ISBN 9789461821904 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Tak PP, Baeten DLP; copromotor(s): )
Ambarus CA, Krausz S, van Eijk M, Hamann J, Radstake TRDJ, Reedquist KA, Tak PP, Baeten DLP, Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J IMMUNOL METHODS 2012;375 (1-2):196-206 [PubMed]
Ambarus CA, Noordenbos T, de Hair MJH, Tak PP, Baeten DLP, Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis. ARTHRITIS RES THER 2012;14 (2):R74 [PubMed]
Ambarus CA, Santegoets KCM, van Bon L, Wenink MH, Tak PP, Radstake TRDJ, Baeten DLP, Soluble Immune Complexes Shift the TLR-Induced Cytokine Production of Distinct Polarized Human Macrophage Subsets towards IL-10. PLOS ONE 2012;7 (4):e35994 [PubMed]
Ambarus C, Yeremenko N, Tak PP, Baeten D, Pathogenesis of spondyloarthritis: autoimmune or autoinflammatory?. CURR OPIN RHEUMATOL 2012;24 (4):351-358 [PubMed]
Burgemeister LT, Baeten DLP, Tas SW, Biologics for rare inflammatory diseases: TNF blockade in the SA PHO syndrome. NETH J MED 2012;70 (10):444-449 [PubMed]
Cantaert T, Doorenspleet ME, Francosalinas G, Paramarta JE, Klarenbeek PL, Tiersma Y, van der Loos CM, de Vries N, Tak PP, Baeten DL, Increased numbers of CD5+ B lymphocytes with a regulatory phenotype in spondylarthritis. ARTHRITIS RHEUM-US 2012;64 (6):1859-1868 [PubMed]
Franco Salinas G. From autoimmunity to autoimmune disease. s.l.: s.n.; 2012. 196p. ISBN 9789461821683 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Tak PP; copromotor(s): Baeten DL)
Klarenbeek PL, de Hair MJH, Doorenspleet ME , van Schaik BDC, Esveldt REE, van de Sande MGH, Cantaert T, Gerlag DM, Baeten D, van Kampen AHC, Baas F, Tak PP, de Vries N, Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease. ANN RHEUM DIS 2012;71 (6):1088-1093 [PubMed]
Krausz S, Garcia S, Ambarus CA, de Launay D, Foster M, Naiman B, Iverson W, Connor JR, Sleeman MA, Coyle AJ, Hamann J, Baeten D, Tak PP, Reedquist KA, Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis. ANN RHEUM DIS 2012;71 (8):1402-1410 [PubMed]
Noordenbos T, Yeremenko N, Gofita I, van de Sande M, Tak PP, Caňete JD, Baeten D, Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. ARTHRITIS RHEUM-US 2012;64 (1):99-109 [PubMed]
Salinas GF, Krausz S, Dontje W, Evavold BD, Tak PP, Baeten DL, Reedquist KA, Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis. J NEUROIMMUNOL 2012;250 (1-2):35-43 [PubMed]
Talabot-Ayer D, McKee T, Gindre P, Bas S, Baeten DL, Gabay C, Palmer G, Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. JOINT BONE SPINE 2012;79 (1):32-37 [PubMed]
van Duivenvoorde LM, Dorris ML, Satumtira N, van Tok MN, Redlich K, Tak PP, Taurog JD, Baeten DL, Relationship between inflammation, bone destruction, and osteoproliferation in the HLA-B27/human beta(2)-microglobulin-transgenic rat model of spondylarthritis. ARTHRITIS RHEUM-US 2012;64 (10):3210-3219 [PubMed]
Audo R, Calmon-Hamaty F, Baeten D, Bruyer A, Combe B, Hahne M, Morel J, Mechanisms and clinical relevance of TRAIL-triggered responses in the synovial fibroblasts of patients with rheumatoid arthritis. ARTHRITIS RHEUM-US 2011;63 (4):904-913 [PubMed]
Baeten DLP. Etiology, pathogenesis, and pathophysiology of ankylosing spondylitis in: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology fifth edition volume 1. Philadelphia: Mosby Elsevier; 2011. 2, p. 1135-1155
Dougados M, Baeten D, Spondyloarthritis. LANCET 2011;377 (9783):2127-2137 [PubMed]
Francosalinas G, Mai HL, Jovanovic V, Moizant F, Vanhove B, Boeffard F, Usal C, Tak PP, Soulillou JP, Baeten D, Brouard S, TNF blockade abrogates the induction of T cell-dependent humoral responses in an allotransplantation model. J LEUKOCYTE BIOL 2011;90 (2):367-375 [PubMed]
Gaston JSH, Goodall JC, Baeten D, Interleukin-23: a central cytokine in the pathogenesis of spondylarthritis. ARTHRITIS RHEUM-US 2011;63 (12):3668-3671 [PubMed]
Klaasen R, Cantaert T, Wijbrandts CA, Teitsma C, Gerlag DM, Out TA, de Nooijer MJ, Baeten D, Tak PP, The value of rheumatoid factor and anti-citrullinated protein antibodies as predictors of response to infliximab in rheumatoid arthritis: an exploratory study. RHEUMATOLOGY 2011;50 (8):1487-1493 [PubMed]
Paramarta JE, Baeten D, de Rycke L, Synovial Tissue Response to Treatment with TNF Blockers in Peripheral Spondyloarthritis. OPEN RHEUMATOL J 2011;5:127-132 [PubMed]
Postema PG, Legemate DA, Baeten DLP, Speelman P, Pneumococcal aortitis: an insidious diagnosis. NETH J MED 2011;69 (1):31-34 [PubMed]
van Rappard DC, Mooij JE, Baeten DLP, Mekkes JR, New-onset polyarthritis during successful treatment of hidradenitis suppurativa with infliximab. BRIT J DERMATOL 2011;165 (1):194-198 [PubMed]
Waldburger JM, Palmer G, Seemayer C, Lamacchia C, Finckh A, Christofilopoulos P, Baeten D, Reith W, Gabay C, Autoimmunity and inflammation are independent of class II transactivator type PIV-dependent class II major histocompatibility complex expression in peripheral tissues during collagen-induced arthritis. ARTHRITIS RHEUM-US 2011;63 (11):3354-3363 [PubMed]
Yeremenko N, Baeten D, IL-17 in spondyloarthritis: is the T-party over?. ARTHRITIS RES THER 2011;13 (3):115 [PubMed]
Baeten D, van Hagen PM, Use of TNF blockers and other targeted therapies in rare refractory immune-mediated inflammatory diseases: evidence-based or rational?. ANN RHEUM DIS 2010;69 (12):2067-2073 [PubMed]
Cantaert T, Baeten D, Tak PP, van Baarsen LGM, Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance. ARTHRITIS RES THER 2010;12 (5):219 [PubMed]
Cantaert T, van Baarsen LG, Wijbrandts CA, Thurlings RM, van de Sande MG, Bos C, van der Pouw TK, Verweij CL, Tak PP, Baeten DL, Type I interferons have no major influence on humoral autoimmunity in rheumatoid arthritis. RHEUMATOLOGY 2010;49 (1):156-166 [PubMed]
de Rycke L, Maas M, Tak PP, Baeten D, 'MRI-tis' in the early diagnosis of axial SpA: issues and limitations. NAT REV RHEUMATOL 2010;6 (11):666-669 [PubMed]
van Baarsen LGM, Wijbrandts CA, Rustenburg F, Cantaert T, van der Pouw Kraan TCTM, Baeten DL, Dijkmans BAC, Tak PP, Verweij CL, Regulation of interferon response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment. ARTHRITIS RES THER 2010;12 (1):R11 [PubMed]
van Kuijk AWR, Degroot J, Koeman RC, Sakkee N, Baeten DL, Gerlag DM, Tak PP, Soluble Biomarkers of Cartilage and Bone Metabolism in Early Proof of Concept Trials in Psoriatic Arthritis: Effects of Adalimumab Versus Placebo. PLOS ONE 2010;5 (9):e12556 [PubMed]
Baeten D, van Hagen M, Magro F, Filipe P, Fonseca JE, Immune-mediated inflammatory diseases: a new multidisciplinary concept Immune-mediated inflammatory diseases: a new multidisciplinary concept. ACTA REUMATOL PORT 2009;34 (3):457-459 [PubMed]
Barthel C, Yeremenko N, Jacobs R, Schmidt RE, Bernateck M, Zeidler H, Tak PP, Baeten D, Rihl M, Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis. ARTHRITIS RES THER 2009;11 (3):R82 [PubMed]
Canete JD, Celis R, Noordenbos T, Moll C, Gomez-Puerta JA, Pizcueta P, Palacin A, Tak PP, Sanmarti R, Baeten D, Distinct synovial immunopathology in Behcet disease and psoriatic arthritis. ARTHRITIS RES THER 2009;11 (1):R17 [PubMed]
Cantaert T, Brouard S, Thurlings RM, Pallier A, Salinas GF, Braud C, Klarenbeek PL, de Vries N, Zhang Y, Soulillou JP, Tak PP, Baeten D, Alterations of the Synovial T Cell Repertoire in Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis. ARTHRITIS RHEUM-US 2009;60 (7):1944-1956 [PubMed]
Cantaert T, de Rycke L, Mavragani CP, Wijbrandts CA, Niewold TB, Niers T, Vandooren B, Veys EM, Richel D, Tak PP, Crow MK, Baeten D, Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade. ANN RHEUM DIS 2009;68 (6):1022-1029 [PubMed]
Klaasen R, Thurlings RM, Wijbrandts CA, van Kuijk AW, Baeten D, Gerlag DM, Tak PP, The Relationship Between Synovial Lymphocyte Aggregates and the Clinical Response to Infliximab in Rheumatoid Arthritis A Prospective Study. ARTHRITIS RHEUM-US 2009;60 (11):3217-3224 [PubMed]
Lories RJ, Baeten DLP, Differences in pathophysiology between rheumatoid arthritis and ankylosing spondylitis. CLIN EXP RHEUMATOL 2009;27 (4 Suppl 55):S10-S14 [PubMed]
Vandooren B, Cantaert T, van Lierop MJ, Bos E, de Rycke L, Veys EM, de Keyser F, Bresnihan B, Luyten FP, Verdonk PC, Tak PP, Boots AH, Baeten D, Melanoma inhibitory activity, a biomarker related to chondrocyte anabolism, is reversibly suppressed by proinflammatory cytokines in rheumatoid arthritis. ANN RHEUM DIS 2009;68 (6):1044-1050 [PubMed]
Vandooren B, Melis L, Veys EM, Tak PP, Baeten D, In Vitro Spontaneous Osteoclastogenesis of Human Peripheral Blood Mononuclear Cells Is Not Crucially Dependent on T Lymphocytes. ARTHRITIS RHEUM-US 2009;60 (4):1020-1025 [PubMed]
Vandooren B, Noordenbos T, Ambarus C, Krausz S, Cantaert T, Yeremenko N, Boumans M, Lutter R, Tak PP, Baeten D, Absence of a Classically Activated Macrophage Cytokine Signature in Peripheral Spondylarthritis, Including Psoriatic Arthritis. ARTHRITIS RHEUM-US 2009;60 (4):966-975 [PubMed]
Vandooren BRM. Mediators of joint remodeling in spondyloarthritis. s.l.: s.n.; 2009. 282p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Tak PP; copromotor(s): Baeten DL)
Vandooren B, Tak PP, Baeten D, Synovial and mucosal immunopathology in spondyloarthritis. ADV EXP MED BIOL 2009;649:71-84 [PubMed]
Vandooren B, Yeremenko N, Noordenbos T, Bras J, Tak PP, Baeten D, Mediators of structural remodeling in peripheral spondylarthritis. ARTHRITIS RHEUM-US 2009;60 (12):3534-3545 [PubMed]
Baeten D, Kruithof E, Breban M, Tak PP, Spondylarthritis in the absence of B lymphocytes. ARTHRITIS RHEUM-US 2008;58 (3):730-733 [PubMed]
Braud C, Baeten D, Giral M, Pallier A, Ashton-Chess J, Braudeau C, Chevalier C, Lebars A, Léger J, Moreau A, Pechkova E, Nicolini C, Soulillou JP, Brouard S, Immunosuppressive drug-free operational immune tolerance in human kidney transplant recipients: Part I. Blood gene expression statistical analysis. J CELL BIOCHEM 2008;103 (6):1681-1692 [PubMed]
Cantaert T. How is autoimmunity against citrullinated proteins regulated?. s.l.: s.n.; 2008. 259p. ISBN 9789090236094 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Tak PP; copromotor(s): Baeten DL)
Cantaert T, Kolln J, Timmer T, van der Pouw Kraan TC, Vandooren B, Thurlings RM, Cañete JD, Catrina AI, Out T, Verweij CL, Zhang Y, Tak PP, Baeten D, B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis. J IMMUNOL 2008;181 (1):785-794 [PubMed]
Cantaert T, Stone MA, ter Borg M, Mogg R, de Vries N, Wilson AG, Tak PP, Baeten D, A functional polymorphism of TIR-domain-containing adaptor protein is not associated with axial spondyloarthritis. ANN RHEUM DIS 2008;67 (5):720-722 [PubMed]
Gerlag DM. Rheumatoid arthritis: of mice and man. Towards the development of innovative therapies for rheumatoid arthritis. s.l.: s.n.; 2008. 194p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Levi MM; copromotor(s): Firestein GS, Baeten DL)
Polzer K, Baeten D, Soleiman A, Distler J, Gerlag DM, Tak PP, Schett G, Zwerina J, Tumour necrosis factor blockade increases lymphangiogenesis in murine and human arthritic joints. ANN RHEUM DIS 2008;67 (11):1610-1616 [PubMed]
Rihl M, Kellner H, Kellner W, Barthel C, Yu DTY, Tak PP, Zeidler H, Baeten D, Identification of Interleukin-7 as a Candidate Disease Mediator in Spondylarthritis. ARTHRITIS RHEUM-US 2008;58 (11):3430-3435 [PubMed]
Straub RH, Pongratz G, Cutolo M, Wijbrandts CA, Baeten D, Fleck M, Atzeni F, Grunke M, Kalden JR, Schölmerich J, Lorenz HM, Tak PP, Sarzi-Puttini P, Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis. ARTHRITIS RHEUM-US 2008;58 (4):976-984 [PubMed]
Thurlings RM, Wijbrandts CA, Mebius RE, Cantaert T, Dinant HJ, van der Pouw-Kraan TCTM, Verweij CL, Baeten D, Tak PP, Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype. ARTHRITIS RHEUM-US 2008;58 (6):1582-1589 [PubMed]
Vandooren B, Cantaert T, Borg MT, Noordenbos T, Kuhlman R, Gerlag D, Bongartz T, Reedquist K, Tak PP, Baeten D, Tumor Necrosis Factor alpha Drives Cadherin 11 Expression in Rheumatoid Inflammation. ARTHRITIS RHEUM-US 2008;58 (10):3051-3062 [PubMed]
Vandooren B, Cantaert T, Noordenbos T, Tak PP, Baeten D, The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation. ARTHRITIS RHEUM-US 2008;58 (3):718-729 [PubMed]
Vergunst CE, Gerlag DM, Lopatinskaya L, Klareskog L, Smith MD, van den Bosch F, Dinant HJ, Lee Y, Wyant T, Jacobson EW, Baeten D, Tak PP, Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial. ARTHRITIS RHEUM-US 2008;58 (7):1931-1939 [PubMed]
Wijbrandts CA, Remans PH, Klarenbeek PL, Wouters D, van den Bergh Weerman MA, Smeets TJ, Vervoordeldonk MJ, Baeten D, Tak PP, Analysis of Apoptosis in Peripheral Blood and Synovial Tissue Very Early After Initiation of Infliximab Treatment in Rheumatoid Arthritis Patients. ARTHRITIS RHEUM-US 2008;58 (11):3330-3339 [PubMed]
Bongartz T, Cantaert T, Atkins SR, Harle P, Myers JL, Turesson C, Ryu JH, Baeten D, Matteson EL, Citrullination in extra-articular manifestations of rheumatoid arthritis. RHEUMATOLOGY 2007;46 (1):70-75 [PubMed]
Brouard S, Mansfield E, Braud C, Li L, Giral M, Hsieh SC, Baeten D, Zhang M, Ashton-Chess J, Braudeau C, Hsieh F, Dupont A, Pallier A, Moreau A, Louis S, Ruiz C, Salvatierra O, Soulillou JP, Sarwal M, Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. P NATL ACAD SCI USA 2007;104 (39):15448-15453 [PubMed]
Cañete JD, Santiago B, Cantaert T, Sanmartí R, Palacin A, Celis R, Graell E, Gil-Torregrosa B, Baeten D, Pablos JL, Ectopic lymphoid neogenesis in psoriatic arthritis. ANN RHEUM DIS 2007;66 (6):720-726 [PubMed]
Da RR, Qin Y, Baeten D, Zhang Y, B cell clonal expansion and somatic hypermutation of Ig variable heavy chain genes in the synovial membrane of patients with osteoarthritis. J IMMUNOL 2007;178 (1):557-565 [PubMed]
van Lierop MJC, den Hoed L, Houbiers J, Vencovsky J, Ruzickova S, Krystufkova O, van Schaardenburg M, van den Hoogen F, Vandooren B, Baeten D, de Keyser F, Sonderstrup G, Bos E, Boots AM, Endogenous HLA-DR-restricted presentation of the cartilage antigens human cartilage gp-39 and melanoma inhibitory activity in the inflamed rheumatoid joint. ARTHRITIS RHEUM-US 2007;56 (7):2150-2159 [PubMed]
Baeten D, Houbiers J, Kruithof E, Vandooren B, van den Bosch F, Boots AM, Veys EM, Miltenburg AMM, de Keyser F, Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis. ANN RHEUM DIS 2006;65 (8):990-997 [PubMed]
Baeten D, Louis S, Braud C, Braudeau C, Ballet C, Moizant F, Pallier A, Giral M, Brouard S, Soulillou JP, Phenotypically and functionally distinct CD8+ lymphocyte populations in long-term drug-free tolerance and chronic rejection in human kidney graft recipients. J AM SOC NEPHROL 2006;17 (1):294-304 [PubMed]
Bettelli E, Baeten D, Jäger A, Sobel RA, Kuchroo VK, Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J CLIN INVEST 2006;116 (9):2393-2402 [PubMed]
Cantaert T, de Rycke L, Bongartz T, Matteson EL, Tak PP, Nicholas AP, Baeten D, Citrullinated proteins in rheumatoid arthritis: crucial...but not sufficient!. ARTHRITIS RHEUM-US 2006;54 (11):3381-3389 [PubMed]
de Rycke L, Kruithof E, Vandooren B, Tak PP, Baeten D, Pathogenesis of spondyloarthritis: insights from synovial membrane studies. CURR RHEUMATOL REP 2006;8 (4):275-282 [PubMed]
Haringman JJ, Gerlag DM, Smeets TJM, Baeten D, van den Bosch F, Bresnihan B, Breedveld FC, Dinant HJ, Legay F, Gram H, Loetscher P, Schmouder R, Woodworth T, Tak PP, A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. ARTHRITIS RHEUM-US 2006;54 (8):2387-2392 [PubMed]
Kruithof E, de Rycke L, Vandooren B, de Keyser F, Fitzgerald O, McInnes I, Tak PP, Bresnihan B, Veys EM, Baeten D, Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis. ARTHRITIS RHEUM-US 2006;54 (6):1795-1804 [PubMed]
Kruithof E, van den Bossche V, de Rycke L, Vandooren B, Joos R, Cañete JD, Tak PP, Boots AMH, Veys EM, Baeten D, Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis. ARTHRITIS RHEUM-US 2006;54 (8):2594-2604 [PubMed]
Rudwaleit M, Baeten D, Ankylosing spondylitis and bowel disease. BEST PRACT RES CL RH 2006;20 (3):451-471 [PubMed]
Smith MD, Baeten D, Ulfgren AK, McInnes IB, FitzGerald O, Bresnihan B, Tak PP, Veale D, Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go?. ANN RHEUM DIS 2006;65 (1):93-100 [PubMed]
Baeten D, Kruithof E, de Rycke L, Boots AM, Mielants H, Veys EM, de Keyser F, Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy. ARTHRITIS RES THER 2005;7 (2):R359-R369 [PubMed]
Bresnihan B, Baeten D, Firestein GS, Fitzgerald OM, Gerlag DM, Haringman JJ, McInnes IB, Reece RJ, Smith MD, Ulfgren AK, Veale DJ, Tak PP, Synovial tissue analysis in clinical trials. J RHEUMATOL 2005;32 (12):2481-2484 [PubMed]
Cantaert T, Coucke P, de Rycke L, Veys EM, de Keyser F, Baeten D, Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies. ANN RHEUM DIS 2005;64 (9):1316-1320 [PubMed]
Chapuy-Regaud S, Sebbag M, Baeten D, Clavel C, Foulquier C, de Keyser F, Serre G, Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitides. J IMMUNOL 2005;174 (8):5057-5064 [PubMed]
Demetter P, de Vos M, van Huysse JA, Baeten D, Ferdinande L, Peeters H, Mielants H, Veys EM, de Keyser F, Cuvelier CA, Colon mucosa of patients both with spondyloarthritis and Crohn's disease is enriched with macrophages expressing the scavenger receptor CD163. ANN RHEUM DIS 2005;64 (2):321-324 [PubMed]
de Rycke L, Baeten D, Foell D, Kruithof E, Veys EM, Roth J, de Keyser F, Differential expression and response to anti-TNFalpha treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis. J PATHOL 2005;206 (1):17-27 [PubMed]
de Rycke L, Baeten D, Kruithof E, van den Bosch F, Veys EM, de Keyser F, Infliximab, but not etanercept, induces IgM anti-double-stranded DNA autoantibodies as main antinuclear reactivity: biologic and clinical implications in autoimmune arthritis. ARTHRITIS RHEUM-US 2005;52 (7):2192-2201 [PubMed]
de Rycke L, Baeten D, Kruithof E, van den Bosch F, Veys EM, de Keyser F, The effect of TNFalpha blockade on the antinuclear antibody profile in patients with chronic arthritis: biological and clinical implications. LUPUS 2005;14 (12):931-937 [PubMed]
de Rycke L, Nicholas AP, Cantaert T, Kruithof E, Echols JD, Vandekerckhove B, Veys EM, de Keyser F, Baeten D, Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity. ARTHRITIS RHEUM-US 2005;52 (8):2323-2330 [PubMed]
de Rycke L, Vandooren B, Kruithof E, de Keyser F, Veys EM, Baeten D, Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy. ARTHRITIS RHEUM-US 2005;52 (7):2146-2158 [PubMed]
Haringman JJ, Gerlag DM, Zwinderman AH, Smeets TJM, Kraan MC, Baeten D, McInnes IB, Bresnihan B, Tak PP, Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis. ANN RHEUM DIS 2005;64 (6):834-838 [PubMed]
Kruithof E, Baeten D, de Rycke L, Vandooren B, Foell D, Roth J, Cañete JD, Boots AM, Veys EM, de Keyser F, Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis. ARTHRITIS RES THER 2005;7 (3):R569-R580 [PubMed]
Kruithof E, Baeten D, van den Bosch F, Mielants H, Veys EM, de Keyser F, Histological evidence that infliximab treatment leads to downregulation of inflammation and tissue remodelling of the synovial membrane in spondyloarthropathy. ANN RHEUM DIS 2005;64 (4):529-536 [PubMed]
Kruithof E, de Rycke L, Roth J, Mielants H, van den Bosch F, de Keyser F, Veys EM, Baeten D, Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathies. ARTHRITIS RHEUM-US 2005;52 (12):3898-3909 [PubMed]
Mielants H, de Keyser F, Baeten D, van den Bosch F, Gut inflammation in the spondyloarthropathies. CURR RHEUMATOL REP 2005;7 (3):188-194 [PubMed]
Rihl M, Kruithof E, Barthel C, de Keyser F, Veys EM, Zeidler H, Yu DTY, Kuipers JG, Baeten D, Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment. ANN RHEUM DIS 2005;64 (11):1542-1549 [PubMed]
Vander Cruyssen B, Hoffman IEA, Zmierczak H, van den Berghe M, Kruithof E, de Rycke L, Mielants H, Veys EM, Baeten D, de Keyser F, Anti-citrullinated peptide antibodies may occur in patients with psoriatic arthritis. ANN RHEUM DIS 2005;64 (8):1145-1149 [PubMed]
Baeten D, de Keyser F, The histopathology of spondyloarthropathy. CURR MOL MED 2004;4 (1):1-12 [PubMed]
Baeten D, de Keyser F, Veys EM, Theate Y, Houssiau FA, Durez P, Tumour necrosis factor alpha independent disease mechanisms in rheumatoid arthritis: a histopathological study on the effect of infliximab on rheumatoid nodules. ANN RHEUM DIS 2004;63 (5):489-493 [PubMed]
Baeten D, Kruithof E, de Rycke L, Vandooren B, Wyns B, Boullart L, Hoffman IEA, Boots AM, Veys EM, de Keyser F, Diagnostic classification of spondylarthropathy and rheumatoid arthritis by synovial histopathology: a prospective study in 154 consecutive patients. ARTHRITIS RHEUM-US 2004;50 (9):2931-2941 [PubMed]
Baeten D, Møller HJ, Delanghe J, Veys EM, Moestrup SK, de Keyser F, Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. ARTHRITIS RHEUM-US 2004;50 (5):1611-1623 [PubMed]
Baeten D, Steenbakkers PGA, Rijnders AMW, Boots AM, Veys EM, de Keyser F, Detection of major histocompatibility complex/human cartilage gp-39 complexes in rheumatoid arthritis synovitis as a specific and independent histologic marker. ARTHRITIS RHEUM-US 2004;50 (2):444-451 [PubMed]
Baeten D, Vandooren B, de Rycke L, Veys EM, de Keyser F, Effect of infliximab treatment on T cell cytokine responses in spondylarthropathy: comment on the article by Zou et al. ARTHRITIS RHEUM-US 2004;50 (3):1015-6; author reply 1017 [PubMed]
de Keyser F, Baeten D, van den Bosch F, Kruithof E, Verbruggen G, Mielants H, Veys E, Structure-modifying capacity of anti-tumour necrosis factor-alpha therapy in ankylosing spondylitis. DRUGS 2004;64 (24):2793-2811 [PubMed]
Kruithof E, Baeten D, Veys EM, de Keyser F, Suykens S, de Wilde L, Verdonk R, Case Number 29: Ochronosis: synovial histopathological characteristics. ANN RHEUM DIS 2004;63 (2):130 [PubMed]
Peene I, de Rycke L, Baeten D, Hoffman I, Veys EM, de Keyser F, History and diagnostic value of antibodies to citrullinated proteins in rheumatoid arthritis. INT J IMMUNOPATH PH 2004;17 (2):107-116 [PubMed]
Rihl M, Baeten D, Seta N, Gu J, de Keyser F, Veys EM, Kuipers JG, Zeidler H, Yu DTY, Technical validation of cDNA based microarray as screening technique to identify candidate genes in synovial tissue biopsy specimens from patients with spondyloarthropathy. ANN RHEUM DIS 2004;63 (5):498-507 [PubMed]
Rihl M, Gu J, Baeten D, Märker-Hermann E, Goodall JC, Gaston JSH, Kuipers JG, Zeidler H, Yu DTY, Alpha beta but not gamma delta T cell clones in synovial fluids of patients with reactive arthritis show active transcription of tumour necrosis factor alpha and interferon gamma. ANN RHEUM DIS 2004;63 (12):1673-1676 [PubMed]
Vandooren B, Kruithof E, Yu DTY, Rihl M, Gu J, de Rycke L, van den Bosch F, Veys EM, de Keyser F, Baeten D, Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy. ARTHRITIS RHEUM-US 2004;50 (9):2942-2953 [PubMed]
Wyns B, Sette S, Boullart L, Baeten D, Hoffman IEA, de Keyser F, Prediction of diagnosis in patients with early arthritis using a combined Kohonen mapping and instance-based evaluation criterion. ARTIF INTELL MED 2004;31 (1):45-55 [PubMed]
Yang C, Gu J, Rihl M, Baeten D, Huang F, Zhao M, Zhang H, Maksymowych WP, de Keyser F, Veys EM, Yu DTY, Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis. ARTHRITIS RHEUM-US 2004;51 (5):691-699 [PubMed]
Baeten D, Kruithof E, van den Bosch F, van den Bossche N, Herssens A, Mielants H, de Keyser F, Veys EM, Systematic safety follow up in a cohort of 107 patients with spondyloarthropathy treated with infliximab: a new perspective on the role of host defence in the pathogenesis of the disease?. ANN RHEUM DIS 2003;62 (9):829-834 [PubMed]
de Keyser F, Baeten D, van den Bosch F, Kruithof E, Mielants H, Veys EM, Infliximab in patients who have spondyloarthropathy: clinical efficacy, safety, and biological immunomodulation. RHEUM DIS CLIN N AM 2003;29 (3):463-479 [PubMed]
Steenbakkers PGA, Baeten D, Rovers E, Veys EM, Rijnders AWM, Meijerink J, de Keyser F, Boots AMH, Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies. J IMMUNOL 2003;170 (11):5719-5727 [PubMed]
Baeten D, de Keyser F, Mielants H, Veys EM, Ankylosing spondylitis and bowel disease. BEST PRACT RES CL RH 2002;16 (4):537-549 [PubMed]
Baeten D, de Keyser F, Mielants H, Veys EM, Immune linkages between inflammatory bowel disease and spondyloarthropathies. CURR OPIN RHEUMATOL 2002;14 (4):342-347 [PubMed]
Baeten D, de Keyser F, van Damme N, Veys EM, Mielants H, Influence of the gut and cytokine patterns in spondyloarthropathy. CLIN EXP RHEUMATOL 2002;20 (6 Suppl 28):S38-S42 [PubMed]
Baeten D, Demetter P, Cuvelier CA, Kruithof E, van Damme N, de Vos M, Veys EM, de Keyser F, Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy. J PATHOL 2002;196 (3):343-350 [PubMed]
de Keyser F, Baeten D, van den Bosch F, de Vos M, Cuvelier C, Mielants H, Veys E, Gut inflammation and spondyloarthropathies. CURR RHEUMATOL REP 2002;4 (6):525-532 [PubMed]
Gu J, Märker-Hermann E, Baeten D, Tsai WC, Gladman D, Xiong M, Deister H, Kuipers JG, Huang F, Song YW, Maksymowych W, Kalsi J, Bannai M, Seta N, Rihl M, Crofford LJ, Veys E, de Keyser F, Yu DTY, A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondyloarthropathy patients. RHEUMATOLOGY 2002;41 (7):759-766 [PubMed]
Gu J, Rihl M, Märker-Hermann E, Baeten D, Kuipers JG, Song YW, Maksymowych WP, Burgos-Vargas R, Veys EM, de Keyser F, Deister H, Xiong M, Huang F, Tsai WC, Yu DTY, Clues to pathogenesis of spondyloarthropathy derived from synovial fluid mononuclear cell gene expression profiles. J RHEUMATOL 2002;29 (10):2159-2164 [PubMed]
Kruithof E, Baeten D, Dierckxsens P, Veys EM, de Keyser F, Tenosynovitis with acute onset: unexpected giant cell tumour of the tendon sheath. ANN RHEUM DIS 2002;61 (9):847 [PubMed]
Kruithof E, van den Bosch F, Baeten D, Herssens A, de Keyser F, Mielants H, Veys EM, Repeated infusions of infliximab, a chimeric anti-TNFalpha monoclonal antibody, in patients with active spondyloarthropathy: one year follow up. ANN RHEUM DIS 2002;61 (3):207-212 [PubMed]
van den Bosch F, Kruithof E, Baeten D, Herssens A, de Keyser F, Mielants H, Veys EM, Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (infliximab) versus placebo in active spondylarthropathy. ARTHRITIS RHEUM-US 2002;46 (3):755-765 [PubMed]
VanderBorght A, de Keyser F, Geusens P, de Backer M, Malaise M, Baeten D, van den Bosch F, Veys EM, Raus J, Stinissen P, Dynamic T cell receptor clonotype changes in synovial tissue of patients with early rheumatoid arthritis: effects of treatment with cyclosporin A (Neoral). J RHEUMATOL 2002;29 (3):416-426 [PubMed]
Almqvist KF, Wang L, Wang J, Baeten D, Cornelissen M, Verdonk R, Veys EM, Verbruggen G, Culture of chondrocytes in alginate surrounded by fibrin gel: characteristics of the cells over a period of eight weeks. ANN RHEUM DIS 2001;60 (8):781-790 [PubMed]
Baeten D, Kruithof E, van den Bosch F, Demetter P, van Damme N, Cuvelier C, de Vos M, Mielants H, Veys EM, de Keyser F, Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study. ARTHRITIS RHEUM-US 2001;44 (1):186-195 [PubMed]
Baeten D, Peene I, Union A, Meheus L, Sebbag M, Serre G, Veys EM, de Keyser F, Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies. ARTHRITIS RHEUM-US 2001;44 (10):2255-2262 [PubMed]
Baeten D, van Damme N, van den Bosch F, Kruithof E, de Vos M, Mielants H, Veys EM, de Keyser F, Impaired Th1 cytokine production in spondyloarthropathy is restored by anti-TNFalpha. ANN RHEUM DIS 2001;60 (8):750-755 [PubMed]
Seta N, Granfors K, Sahly H, Kuipers JG, Song YW, Baeten D, Veys EM, Maksymowych W, Märker-Hermann E, Gu J, Huang F, Kirveskari J, Yu DT, Expression of host defense scavenger receptors in spondylarthropathy. ARTHRITIS RHEUM-US 2001;44 (4):931-939 [PubMed]
van Damme N, de Keyser F, Demetter P, Baeten D, Mielants H, Verbruggen G, Cuvelier C, Veys EM, de Vos M, The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome. CLIN EXP IMMUNOL 2001;125 (3):383-390 [PubMed]
van Damme N, de Vos M, Baeten D, Demetter P, Mielants H, Verbruggen G, Cuvelier C, Veys EM, de Keyser F, Flow cytometric analysis of gut mucosal lymphocytes supports an impaired Th1 cytokine profile in spondyloarthropathy. ANN RHEUM DIS 2001;60 (5):495-499 [PubMed]
van Damme N, Elewaut D, Baeten D, Demetter P, Cuvelier C, Verbruggen G, Mielants H, Veys EM, de Vos M, de Keyser F, Gut mucosal T cell lines from ankylosing spondylitis patients are enriched with alphaEbeta7 integrin. CLIN EXP RHEUMATOL 2001;19 (6):681-687 [PubMed]
van den Bosch F, Baeten D, Kruithof E, de Keyser F, Mielants H, Veys EM, Treatment of active spondyloarthropathy with infliximab, the chimeric monoclonal antibody to tumour necrosis factor alpha. ANN RHEUM DIS 2001;60 (Suppl. 3):iii33-iii36 [PubMed]
van den Bosch F, Baeten D, Kruithof E, de Keyser F, Veys EM, Characteristic marco- and microscopic aspect of the synovial membrane in crystal induced arthritis. J RHEUMATOL 2001;28 (2):392-393 [PubMed]
Baeten D, Boots AM, Steenbakkers PG, Elewaut D, Bos E, Verheijden GF, Berheijden G, Miltenburg AM, Rijnders AW, Veys EM, de Keyser F, Human cartilage gp-39+,CD16+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis. ARTHRITIS RHEUM-US 2000;43 (6):1233-1243 [PubMed]
Baeten D, Demetter P, Cuvelier C, van den Bosch F, Kruithof E, van Damme N, Verbruggen G, Mielants H, Veys EM, de Keyser F, Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity. ANN RHEUM DIS 2000;59 (12):945-953 [PubMed]
Demetter P, Baeten D, de Keyser F, de Vos M, van Damme N, Verbruggen G, Vermeulen S, Mareel M, Elewaut D, Mielants H, Veys EM, Cuvelier CA, Subclinical gut inflammation in spondyloarthropathy patients is associated with upregulation of the E-cadherin/catenin complex. ANN RHEUM DIS 2000;59 (3):211-216 [PubMed]
Demetter P, de Vos M, van Damme N, Baeten D, Elewaut D, Vermeulen S, Mareel M, Bullock G, Mielants H, Verbruggen G, de Keyser F, Veys EM, Cuvelier CA, Focal up-regulation of E-cadherin-catenin complex in inflamed bowel mucosa but reduced expression in ulcer-associated cell lineage. AM J CLIN PATHOL 2000;114 (3):364-370 [PubMed]
van Damme N, Baeten D, de Vos M, Demetter P, Elewaut D, Mielants H, Verbruggen G, Cuvelier C, Veys EM, de Keyser F, Chemical agents and enzymes used for the extraction of gut lymphocytes influence flow cytometric detection of T cell surface markers. J IMMUNOL METHODS 2000;236 (1-2):27-35 [PubMed]
van den Bosch F, Kruithof E, Baeten D, de Keyser F, Mielants H, Veys EM, Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study. ANN RHEUM DIS 2000;59 (6):428-433 [PubMed]
Baeten D, van den Bosch F, Elewaut D, Stuer A, Veys EM, de Keyser F, Needle arthroscopy of the knee with synovial biopsy sampling: technical experience in 150 patients. CLIN RHEUMATOL 1999;18 (6):434-441 [PubMed]
Elewaut D, de Keyser F, de Wever N, Baeten D, van Damme N, Verbruggen G, Cuvelier C, Veys EM, A comparative phenotypical analysis of rheumatoid nodules and rheumatoid synovium with special reference to adhesion molecules and activation markers. ANN RHEUM DIS 1998;57 (8):480-486 [PubMed]
Elewaut D, van Damme N, de Keyser F, Baeten D, de Paepe P, van Vlierberghe H, Mielants H, Cuvelier C, Verbruggen G, Veys EM, de Vos M, Altered expression of alpha E beta 7 integrin on intra-epithelial and lamina propria lymphocytes in patients with Crohn's disease. ACTA GASTRO-ENT BELG 1998;61 (3):288-294 [PubMed]
Verbruggen G, Verdonk R, Veys EM, van Daele P, de Smet P, van den Abbeele K, Claus B, Baeten D, Human meniscal proteoglycan metabolism in long-term tissue culture. KNEE SURG SPORT TR A 1996;4 (1):57-63 [PubMed]
Key publications

Dougados M, Baeten D, Spondyloarthritis. LANCET 2011;377 (9783):2127-2137 [PubMed]
Baeten D, Baraliakos X, Braun J, Sieper J, Emery P, van der Heijde D, McInnes I, van Laar JM, Landewé R, Wordsworth P, Wollenhaupt J, Kellner H, Paramarta J, Wei J, Brachat A, Bek S, Laurent D, Li Y, Wang YA, Bertolino AP, Gsteiger S, Wright AM, Hueber W, Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. LANCET 2013;382 (9906):1705-1713 [PubMed]
Baeten DLP , Kuchroo VK, How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases. NAT MED 2013;19 (7):824-825 [PubMed]
Baeten D, Sieper J, Braun J, Baraliakos X, Dougados M, Emery P, Deodhar A, Porter B, Martin R, Andersson M, Mpofu S, Richards HB [Contributors: van den Bosch F, Nzeusseu A, de Vlam K, Geusens P, Oparanov B, Rashkov R, Batalov A, Goranov I, Kazmin I, McCarthy T, Inman R, Rahman P, Schaeverbeke T, N'Guyen M, Bertin P, Frediani B, Adami S, Foti R, Triolo G, Fusaro E, Franceschini F, Zazueta B, Maradiaga M, Avila H, Garza M, Baeten D, Bijlsma H, Berrocal A, Garro B, Gamboa R, Castaneda O, Becerra F, Stanislav M, Salnikova T, Maslyanskiy A, Ershova O, Izmozherova N, Lesniak O, Tseng JC, Wei CC, Ozdogan H, Kisacik B, Onen F, Tahir H, Ostor A, Barkham N, Kay L, Braun J, Dahmen G, Rubbert-Roth A, Wassenberg S, Oelzner P, Nuesslein H, Moericke R, Rech J, Sieper J, Deodhar A, Kivitz A, Aelion J, Kohen M, Knibbe W, LaSalle S, Zang S, Cohen S, Brooks M, Graninger W, Jorg R, Zamani O, Bessette L, Cohen M, Beaulieu A, Pavelka K, Galatikova D, Dokoupilova E, Leirisalo-Repo M, Paimela L, Järvinen P, Sokka-Isler T, Rouhe E, keskussairaala S, Pellerito R, Bijlsma J, Trofimov V, Vezikova N, Zotkin E, Mosesova N, Lee LN, Cheung P, Balsa A, Blanco R, Blanco FJ, Gonzalez C, Bannert B, Daniela B, Dudler J, Ciurea A, Marzo-Ortega H, Gaffney K, Mackay K, Codding C, Dorman W, Legerton C 3rd, Khan M, Lee E, Caldron P, Wolfe JF, Swarup A, Singhal A, Tony HP]] , Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis. NEW ENGL J MED 2015;373 (26):2534-2548 [PubMed]
Noordenbos T, Yeremenko N, Gofita I, van de Sande M, Tak PP, Caňete JD, Baeten D, Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. ARTHRITIS RHEUM-US 2012;64 (1):99-109 [PubMed]


All Publications

Curriculum Vitae

NAME: Baeten Dominique, MD, PhD
BIRTH: 12/12/1970

Academic carreer
• Physician (MD), University of Ghent, Belgium, 1995, Cum Maxima Laude
• Doctor in the Medical Sciences (PhD), University of Ghent, Belgium, 2001, Cum Maxima Laude
• Legal Degree of Specialist in Rheumatology, Belgium, 2002
• Assistant Professor (docent), Ghent University, Belgium, 2003
• Associate Professor (hoofddocent) Academic Medical Center/University of Amsterdam, The Netherlands, 2006.
• Professor of Rheumatology, University of Amsterdam, The Netherlands, 2012

Key personal grants and awards
• Fund for Scientific Research-Flanders Research Fellowship (1996)
• Fund for Scientific Research-Flanders Senior Clinical Investigator (2002)
• European League Against Rheumatism Young Investigator Award (2002)
• Academic Medical Center Fellowship (2006)
• NWO Vernieuwingsimpuls VIDI Grant (2007)
• NWO Vernieuwingsimpuls VICI Grant (2014)
• European Research Council (ERC) Consolidator grant (2015)

Key scientific publications
• Baeten D, Bettelli E, et al. J Clin Invest 2006;116:2393-402.
• Dougados M, Baeten D. Lancet 2011;377:2127-37.
• Baeten D, Baraliakos X, et al. Lancet 2013;382:1705-13.
• Baeten D, Kuchroo V. Nat Med 2013;19:824-5.
• Sieper J, Braun J, Dougados M, Baeten D. Nat Rev Dis Prim 2015 (accepted)
• Baeten D, Sieper J, et al. N Engl J Med 2015 (accepted).

Key international experience
• Research Fellowship at INSERM U437, Nantes, France, Oct 2003-Oct 2004.
• Research Fellowship at Harvard Medical School and Brigham and Women’s Hospital, Boston, USA, Oct 2004-Oct 2005.
• Principal Investigator of the Ghent University Hospital in the FP6 program ‘Autocure’
• Co-principal Investigator of the AMC/UvA in the IMI EU program ‘BTCure’
• Chair of the EU COST Action: European Network for Translational Immunology Research and Education (ENTIRE), 2010-2014.

Key managerial experience
• Executive Professional Training, Audencia Business School, Nantes, France, 2004.
• Director of the FOCIS Center of Excellence, Academic Medical Center/University of Amsterdam, The Netherlands, 2006-present.
• Chair of the Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, The Netherlands, 2011- 2013.
• Chair of the EU COST Action: European Network for Translational Immunology Research and Education (ENTIRE), 2010-2014.
 

Research programmes

Immunopathology of chronic inflammatory arthritis

1) B cell autoimmunity: we study the cellular and molecular mechanisms operating in human autoreactive B cells, using mainly ACPA-positive B cells as model. In collaboration with Prof Hergen Spits, we cloned a large series of normal and autoreactive memory B cells from rheumatoid arthritis patients and healthy controls. We study key molecular switches in these cells, including mechanisms related to co-stimulation, germinal center formation, cytokine production, and B-T cell interactions. In collaboration with Dr Niek de Vries, we study the clonal expansion and repertoires of these autoreactive cells.

2) Cellular and molecular pathways of chronic tissue inflammation: using synovial inflammation in human spondyloarthritis as model, we study how key cytokine axis (in particular: TNF and IL-23/IL-17) operate in chronic tissue inflammation.  

3) Animal models of spondyloarthritis: rheumatic diseases are not only characterized by chronic inflammation but also by pronounced structural damage to musculoskeletal organs. Spondyloarthritis is characterized by pathological new bone formation, which is very difficult to study in humans as this is a very slow process and access to tissue samples is difficult. Therefore, we set up animal models of SpA which allow us to mechanistaically study the interaction between inflammation and new bone formation and to preclinically test novel therapeutic strategies.

4) Novel therapies in spondyloarthritis: in this clinical part of our research program, we conduct phase II and IIIa clinical trials (both investigator-initiated and pharma-driven) with novel compounds in spondyloarthritis. Biological samples obtained in these trials are used for translational lab reserach (see 2). Moreover, we study biomarkers that can help us to select and stratify patient populations of appropriate treatment strategies.

5) Fc receptors as key determinants of myeloid cell-driven inflammation: this program is driven by a junior independent researcher, Jeroen den Dunnen (VENI and AMC Fellowship) and studies how different Fc receptors interact with TLRs to determine the myeloid immune response in infection and inflammation.


Theme: Infection and Immunity

Faculty
Prof. dr. D.L.P. Baeten

Postdocs
L.M. van Duivenvoorde PhD
Dr. J. den Dunnen PhD
C.M. Fehres PhD
Dr. M.G.H. van de Sande MD
N.G. Yeremenko PhD

PhD Students
S. Chen
I.S. Hansen
J.W. Hoepel MSc
H.M.Y. de Jong
M.H. Kaaij
P. Kabala MSc
J.N. Kraal MD MSc
M.J. Levels
C.X. Maracle
Dr. L.L.J. Van Mens
A. Musters
M. Newling
Dr. J.J.H. de Winter

Others
I. Blijdorp
J. Burgstede
I. Fluri
T. Heijda
T.E. Latuhihin
M. Leeuw MSc
D. Pots
A. van Tillo
M.N. van Tok
Drs. N.O. van Uden

Other research related activities
  • None reported
Current research funding
  • AbbVie B.V.
  • AMC
  • AMC (Vrijgesteld)
  • Boehringer Ingelheim BV
  • CTC Maastricht
  • Eli Lilly and Company Limited
  • Eli Lilly Nederland BV
  • Europese Unie
  • Janssen Cilag B.V.
  • Jan van Breemen Instituut
  • Merck & Co., Inc
  • Novartis Pharma AG
  • Novartis Pharma BV
  • NWO
  • Reumafonds
  • UCB Celltech