• Male

Dr. J.W.J. van Heijst PhD

Position: Postdoc
Main activities: Research
Specialisation: Molecular Regulation of T cell Immunity
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Focus of research:

We are interested in understanding at a molecular level how T cells provide protection against infectious diseases and cancer. A major research interest focuses on the analysis of T cell immunity to tuberculosis, currently the world’s leading infectious killer. Our primary goal is to determine the mechanistic basis of protective Mycobacterium tuberculosis-specific T cell responses, using a combination of TCR transgenic mouse models and functional genomics tools, and to identify specific bacterial factors that mediate escape from protective T cell responses.

A second research interest focuses on the negative regulation of antigen-specific T cell immunity, via feedback control mechanisms. Concerning this, we have recently identified a new inhibitory mechanism of T cell responses that operates via the programmed downregulation of TCR expression. Currently, we are investigating the molecular pathways underlying this programmed TCR downregulation, ultimately aiming to generate novel therapeutic leads to enhance protective immunity to infection and cancer.

 

AMC themes: Infection & Immunity
Departments: Center of Experimental and Molecular Medicine
Anas AA, de Vos AF, Hoogendijk AJ, van Lieshout MHP, van Heijst JWJ, Florquin S, Li Z, van 't Veer C, van der Poll T, Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia. J PATHOL 2016;238 (1):74-84 [PubMed]
Gallegos AM, Xiong H, Leiner IM, Sušac B, Glickman MS, Pamer EG, van Heijst JWJ, Control of T cell antigen reactivity via programmed TCR downregulation. NAT IMMUNOL 2016;17 (4):379-386 [PubMed]
Gerlach C, Rohr JC, Perié L, van Rooij N, van Heijst JWJ, Velds A, Urbanus J, Naik SH, Jacobs H, Beltman JB, de Boer RJ, Schumacher TNM, Heterogeneous differentiation patterns of individual CD8+ T cells. SCIENCE 2013;340 (6132):635-639 [PubMed]
van Heijst JWJ, Ceberio I, Lipuma LB, Samilo DW, Wasilewski GD, Gonzales AMR, Nieves JL, van den Brink MRM, Perales MA, Pamer EG, Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. NAT MED 2013;19 (3):372-377 [PubMed]
van Heijst JWJ, Pamer EG, Radical host-specific therapies for TB. CELL 2013;153 (3):507-508 [PubMed]
Gallegos AM, van Heijst JWJ, Samstein M, Su X, Pamer EG, Glickman MS, A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo. PLOS PATHOG 2011;7 (5):e1002052 [PubMed]
Gerlach C, van Heijst JWJ, Schumacher TNM, The descent of memory T cells. ANN NY ACAD SCI 2011;1217:139-153 [PubMed]
Gerlach C, van Heijst JWJ, Swart E, Sie D, Armstrong N, Kerkhoven RM, Zehn D, Bevan MJ, Schepers K, Schumacher TNM, One naive T cell, multiple fates in CD8+ T cell differentiation. J EXP MED 2010;207 (6):1235-1246 [PubMed]
Schumacher TNM, Gerlach C, van Heijst JWJ, Mapping the life histories of T cells. NAT REV IMMUNOL 2010;10 (9):621-631 [PubMed]
van Heijst JWJ, Gerlach C, Swart E, Sie D, Nunes-Alves C, Kerkhoven RM, Arens R, Correia-Neves M, Schepers K, Schumacher TNM, Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient. SCIENCE 2009;325 (5945):1265-1269 [PubMed]
Coccoris M, Swart E, de Witte MA, van Heijst JWJ, Haanen JBAG, Schepers K, Schumacher TNM, Long-term functionality of TCR-transduced T cells in vivo. J IMMUNOL 2008;180 (10):6536-6543 [PubMed]
Schepers K, Swart E, van Heijst JWJ, Gerlach C, Castrucci M, Sie D, Heimerikx M, Velds A, Kerkhoven RM, Arens R, Schumacher TNM, Dissecting T cell lineage relationships by cellular barcoding. J EXP MED 2008;205 (10):2309-2318 [PubMed]
van Heijst JWJ, Niessen HWM, Musters RJ, van Hinsbergh VWM, Hoekman K, Schalkwijk CG, Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis. CANCER LETT 2006;241 (2):309-319 [PubMed]
van Heijst JWJ, Niessen HWM, Hoekman K, Schalkwijk CG, Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine. ANN NY ACAD SCI 2005;1043:725-733 [PubMed]
Key publications

Gallegos AM, Xiong H, Leiner IM, Sušac B, Glickman MS, Pamer EG, van Heijst JWJ, Control of T cell antigen reactivity via programmed TCR downregulation. NAT IMMUNOL 2016;17 (4):379-386 [PubMed]
van Heijst JWJ, Pamer EG, Radical host-specific therapies for TB. CELL 2013;153 (3):507-508 [PubMed]
van Heijst JWJ, Ceberio I, Lipuma LB, Samilo DW, Wasilewski GD, Gonzales AMR, Nieves JL, van den Brink MRM, Perales MA, Pamer EG, Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. NAT MED 2013;19 (3):372-377 [PubMed]
Schumacher TNM, Gerlach C, van Heijst JWJ, Mapping the life histories of T cells. NAT REV IMMUNOL 2010;10 (9):621-631 [PubMed]
van Heijst JWJ, Gerlach C, Swart E, Sie D, Nunes-Alves C, Kerkhoven RM, Arens R, Correia-Neves M, Schepers K, Schumacher TNM, Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient. SCIENCE 2009;325 (5945):1265-1269 [PubMed]


All Publications

Research programmes

Prof. dr. T. van der Poll (Innate immunity and coagulation in infection)

Other research related activities
  • None reported
Current research funding
  • ZonMw