• Principal Investigator
  • Female

Prof. dr. A.E. Goudriaan

Position: Professor
Main activities: Research, Patient care
Specialisation: Bijzonder hoogleraar: Werkingsmechanismen en behandeling van verslaving
foto A.E. Goudriaan is one of the AMC Principal Investigators
Focus of research:

Neurocognitive, neuroimaging and epidemiological research of (sub)clinical dependence, with a focus on the influence of self-regulation and motivational functions on the course of addictive disorders.  Neuroimaging and psychopharmacology of addictive disorders ( pathological gambling, at-risk young adult cannabis users, chronic alcohol dependent and cocaine dependent populations, problematic video gamers). Discovering the neurobiological mechanisms underlying the development and course of addictive disorders; e.g. structural brain abnormalities associated with cannabis use (MRI, DTI) and neurocognitive processes associated with changes in cannabis use over time.

These research aims are established through research on motivational processes such as cue-responsivity,and cognitive processes such as response inhibition, cognitive flexibility, and working memory in the brain (functional MRI) and through neurocognitive tests. Pharmacological effects of agents known to improve cognitive functions in addictive disorders are studied, in order to investigate whether impulsivity – which is related to relapse and early treatment drop-out in addiction – can be improved by these pharmacological agents. In the most recent pharmacological fMRI study, we intend to measure the neural mechanism of naltrexone, and to investigate the relationship between clinical effects, and neural effects of slow-release naltrexone, through functional MRI, magnetic resonance spectroscopy, and dopamine-receptor binding, using SPECT.

AMC themes: Neurological & Psychiatric Disorders
Departments: Psychiatry: Adult Psychiatry
Beraha EM, Salemink E, Goudriaan AE, van den Brink W, Wiers RW, Response to "Baclofen and alcohol use disorders: From miracle to mirage". EUR NEUROPSYCHOPHARM 2017;27 (7):693-694 [PubMed]
Chye Y, Solowij N, Ganella EP, Suo C, Yücel M, Batalla A, Cousijn J, Goudriaan AE, Martin-Santos R, Whittle S, Bartholomeusz CF, Lorenzetti V, Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms. PROG NEURO-PSYCHOPH 2017;79 (B):392-400 [PubMed]
Chye Y, Solowij N, Suo C, Batalla A, Cousijn J, Goudriaan AE, Martin-Santos R, Whittle S, Lorenzetti V, Yücel M, Orbitofrontal and caudate volumes in cannabis users: a multi-site mega-analysis comparing dependent versus non-dependent users. PSYCHOPHARMACOLOGY 2017;234 (13):1985-1995 [PubMed]
de Waal MM, Dekker JJM, Goudriaan AE, Prevalence of Victimization in Patients With Dual Diagnosis. J DUAL DIAGN 2017;13 (2):119-123 [PubMed]
de Waal MM, Dekker JJM, Kikkert MJ, Kleinhesselink MD, Goudriaan AE, Gender differences in characteristics of physical and sexual victimization in patients with dual diagnosis: a cross-sectional study. BMC PSYCHIATRY 2017;17 (1):270 [PubMed]
Gonzalez MdO, Goudriaan AE, Périco CdAM, Waisman Campos M, de Andrade AG, Bhugra D, Castaldelli-Maia JM, Neural Correlates of Depressive Symptoms in Smokers - A Systematic Review of Imaging Studies. SUBST USE MISUSE 2017;ahead of print [PubMed]
Koenders L, Lorenzetti V, de Haan L, Suo C, Vingerhoets W, van den Brink W, Wiers RW, Meijer CJ, Machielsen M, Goudriaan AE, Veltman DJ, Yücel M, Cousijn J, Longitudinal study of hippocampal volumes in heavy cannabis users. J PSYCHOPHARMACOL 2017;31 (8):1027-1034 [PubMed]
Maniaci G, Goudriaan AE, Cannizzaro C, van Holst RJ, Impulsivity and Stress Response in Pathological Gamblers During the Trier Social Stress Test. J GAMBL STUD 2017;ahead of print [PubMed]
Schulte MHJ, Kaag AM, Wiers RW, Schmaal L, van den Brink W, Reneman L, Homberg JR, van Wingen GA, Goudriaan AE, Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users. DRUG ALCOHOL DEPEN 2017;179:117-123 [PubMed]
van Holst RJ, van Timmeren T, Goudriaan AE, Are There Differences in Disruptions of Reward Processing Between Substance Use Disorder and Gambling Disorder?. JAMA PSYCHIAT 2017;74 (7):759-+ [PubMed]
van Timmeren T, Jansen JM, Caan MWA, Goudriaan AE, van Holst RJ, White matter integrity between left basal ganglia and left prefrontal cortex is compromised in gambling disorder. ADDICT BIOL 2017;22 (6):1590-1600 [PubMed]
Yücel M, Carter A, Allen AR, Balleine B, Clark L, Dowling NA, Gainsbury SM, Goudriaan AE, Grant J, Hayes A, Hodgins D, van Holst R, Lattimore R, Livingstone C, Lorenzetti V, Lubman D, Murawski C, Parkes L, Petry N, Room R, Singh B, Thomas A, Townshend P, Youssef G, Hall W, Neuroscience in gambling policy and treatment: an interdisciplinary perspective. LANCET PSYCHIAT 2017;4 (6):501-506 [PubMed]
Beraha EM, Salemink E, Goudriaan AE, Bakker A, de Jong D, Smits N, Zwart JW, Geest Dv, Bodewits P, Schiphof T, Defourny H, van Tricht M, van den Brink W, Wiers RW, Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial. EUR NEUROPSYCHOPHARM 2016;26 (12):1950-1959 [PubMed]
Burger TJ, Goudriaan AE, de Haan L, de Koning MB, Duwen richting abstinentie: toepassing van drang en dwang bij schizofrenie met comorbide middelenafhankelijkheid. TIJDSCHR PSYCHIATR 2016;58 (6):481-484 [PubMed]
Chamberlain SR, Lochner C, Stein DJ, Goudriaan AE, Holst RVJ, Zohar J, Grant JE, Behavioural addiction-A rising tide?. EUR NEUROPSYCHOPHARM 2016;26 (5):841-855 [PubMed]
Figee M, Pattij T, Willuhn I, Luigjes J, van den Brink W, Goudriaan A, Potenza MN, Robbins TW, Denys D, Compulsivity in obsessive-compulsive disorder and addictions. EUR NEUROPSYCHOPHARM 2016;26 (5):856-868 [PubMed]
Jansen JM. Neurostimulation in alcohol dependence: The effect of repetitive transcranial magnetic stimulation on cognitive functioning and craving. S.l.: s.n.; 2016. 124p. ISBN 9789462954694 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Goudriaan AE, van den Brink W; copromotor(s): )
Koenders L, Cousijn J, Vingerhoets WAM, van den Brink W, Wiers RW, Meijer CJ, Machielsen MWJ, Veltman DJ, Goudriaan AE, de Haan L, Grey Matter Changes Associated with Heavy Cannabis Use: A Longitudinal sMRI Study. PLOS ONE 2016;11 (5):e0152482 [PubMed]
Mackey S, Kan KJ, Chaarani B, Alia-Klein N, Batalla A, Brooks S, Cousijn J, Dagher A, de Ruiter M, Desrivieres S, Feldstein Ewing SW, Goldstein RZ, Goudriaan AE, Heitzeg MM, Hutchison K, Li CSR, London ED, Lorenzetti V, Luijten M, Martin-Santos R, Morales AM, Paulus MP, Paus T, Pearlson G, Schluter R, Momenan R, Schmaal L, Schumann G, Sinha R, Sjoerds Z, Stein DJ, Stein EA, Solowij N, Tapert S, Uhlmann A, Veltman D, van Holst R, Walter H, Wright MJ, Yucel M, Yurgelun-Todd D, Hibar DP, Jahanshad N, Thompson PM, Glahn DC, Garavan H, Conrod P, Genetic imaging consortium for addiction medicine: From neuroimaging to genes. PROG BRAIN RES 2016;224:203-223 [PubMed]
Nuijten M, Blanken P, van den Brink W, Goudriaan AE, Hendriks VM, Impulsivity and attentional bias as predictors of modafinil treatment outcome for retention and drug use in crack-cocaine dependent patients: Results of a randomised controlled trial. J PSYCHOPHARMACOL 2016;30 (7):616-626 [PubMed]
Schaub MP, Blankers M, Lehr D, Boss L, Riper H, Dekker J, Goudriaan AE, Maier LJ, Haug S, Amann M, dey M, Wenger A, Ebert DD, Efficacy of an internet-based self-help intervention to reduce co-occurring alcohol misuse and depression symptoms in adults: study protocol of a three-arm randomised controlled trial. BMJ OPEN 2016;6 (5):e011457 [PubMed]
van den Heuvel OA, van Wingen G, Soriano-Mas C, Alonso P, Chamberlain SR, Nakamae T, Denys D, Goudriaan AE, Veltman DJ, Brain circuitry of compulsivity. EUR NEUROPSYCHOPHARM 2016;26 (5):810-827 [PubMed]
Vingerhoets WAM, Koenders L, van den Brink W, Wiers RW, Goudriaan AE, van Amelsvoort T, de Haan L, Cousijn J, Cue-induced striatal activity in frequent cannabis users independently predicts cannabis problem severity three years later. J PSYCHOPHARMACOL 2016;30 (2):152-158 [PubMed]
Young SY, Delevoye-Turrell Y, van Hoof JJJ, Goudriaan AE, Seedat S, Association between motor timing and treatment outcomes in patients with alcohol and/or cocaine use disorder in a rehabilitation program. BMC PSYCHIATRY 2016;16 (1):273 [PubMed]
Zaaijer E R, Goudriaan AE, Koeter MWJ, Booij J, Wim van den Brink (red.) W, Acceptability of Extended-Release Naltrexone by Heroin-Dependent Patients and Addiction Treatment Providers in the Netherlands. SUBST USE MISUSE 2016;51 (14):1905-1911 [PubMed]
de Mooij LD, Kikkert M, Lommerse NM, Peen J, Meijwaard SC, Theunissen J, Duurkoop PWRA, Goudriaan AE, van HL, Beekman ATF, Dekker JJM, Victimisation in adults with severe mental illness: prevalence and risk factors. BRIT J PSYCHIAT 2015;207 (6):515-522 [PubMed]
de Waal MM, Kikkert MJ, Blankers M, Dekker JJM, Goudriaan AE, Self-wise, Other-wise, Streetwise (SOS) training: a novel intervention to reduce victimization in dual diagnosis psychiatric patients with substance use disorders: protocol for a randomized controlled trial. BMC PSYCHIATRY 2015;15 (1):267 [PubMed]
Jansen JM, van Holst RJ, van den Brink W, Veltman DJ, Caan MWA, Goudriaan AE, Brain function during cognitive flexibility and white matter integrity in alcohol-dependent patients, problematic drinkers and healthy controls. ADDICT BIOL 2015;20 (5):979-989 [PubMed]
Jansen JM, van Wingen G, van den Brink W, Goudriaan AE, Resting state connectivity in alcohol dependent patients and the effect of repetitive transcranial magnetic stimulation. EUR NEUROPSYCHOPHARM 2015;25 (12):2230-2239 [PubMed]
Stevens L, Goudriaan AE, Verdejo-Garcia A, Dom G, Roeyers H, Vanderplasschen W, Impulsive choice predicts short-term relapse in substance-dependent individuals attending an in-patient detoxification programme. PSYCHOL MED 2015;45 (10):2083-2093 [PubMed]
Stevens L, Verdejo-García A, Roeyers H, Goudriaan AE, Vanderplasschen W, Delay discounting, treatment motivation and treatment retention among substance-dependent individuals attending an in inpatient detoxification program. J SUBST ABUSE TREAT 2015;49:58-64 [PubMed]
Zaaijer ER. Chasing the dragon away: Personality as a protective factor and extended-release naltrexone as a treatment for heroin dependence. S.l.: s.n.; 2015. 117p. ISBN 978-94-6182-577-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Booij J, van den Brink W; copromotor(s): Goudriaan AE)
Zaaijer ER, de Bruin K, la Fleur SE, Goudriaan AE, van den Brink W, Booij J, Subchronic administration of short-acting naltrexone has no effect on striatal dopamine transporter availability, food intake or body weight gain in rats. J PSYCHOPHARMACOL 2015;29 (3):344-348 [PubMed]
Zaaijer ER, van Dijk L, de Bruin K, Goudriaan AE, Lammers LA, Koeter MWJ, van den Brink W, Booij J, Effect of extended-release naltrexone on striatal dopamine transporter availability, depression and anhedonia in heroin-dependent patients. PSYCHOPHARMACOLOGY 2015;232 (14):2597-2607 [PubMed]
Boog M, Goudriaan AE, Wetering BJMvd, Polak M, Deuss H, Franken IHA, Rash impulsiveness and reward sensitivity as predictors of treatment outcome in male substance dependent patients. ADDICT BEHAV 2014;39 (11):1670-1675 [PubMed]
Boog M, Höppener P, V D Wetering BJM, Goudriaan AE, Boog MC, Franken IHA, Cognitive inflexibility in gamblers is primarily present in reward-related decision making. FRONT HUM NEUROSCI 2014;8:569 [PubMed]
Cousijn J, Vingerhoets WAM, Koenders L, de Haan L, van den Brink W, Wiers RW, Goudriaan AE, Relationship between working-memory network function and substance use: a 3-year longitudinal fMRI study in heavy cannabis users and controls. ADDICT BIOL 2014;19 (2):282-293 [PubMed]
Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Goudriaan AE, Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: a prospective fMRI study. HUM BRAIN MAPP 2014;35 (5):2470-2482 [PubMed]
Fineberg NA, Chamberlain SR, Goudriaan AE, Stein DJ, Vanderschuren LJMJ, Gillan CM, Shekar S, Gorwood PAPM, Voon V, Morein-Zamir S, Denys D, Sahakian BJ, Moeller FG, Robbins TW, Potenza MN, New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS SPECTRUMS 2014;19 (1):69-89 [PubMed]
Goudriaan AE, Gambling and problem gambling in The Netherlands. ADDICTION 2014;109 (7):1066-1071 [PubMed]
Goudriaan AE. Gokverslaving in: van de Mheen D, editors. Gedragsverslaving?. S.l.: Bohn, Stafleu, van Loghum; 2014., p. -
Goudriaan AE, Stepping up the game. ADDICTION 2014;109 (9):1409-1411 [PubMed]
Goudriaan AE, Yücel M, van Holst RJ, Getting a grip on problem gambling: what can neuroscience tell us?. FRONT BEHAV NEUROSCI 2014;8:141 [PubMed]
Jansen JM, van den Heuvel OA, van der Werf YD, de Wit SJ, Veltman DJ, van den Brink W, Goudriaan AE, Niet-invasieve hersenstimulatie bij verslaving; het effect op craving en emotieregulatie. NEUROPRAXIS 2014;19 (3):54-59
Kräplin A, Bühringer G, Oosterlaan J, van den Brink W, Goschke T, Goudriaan AE, Dimensions and disorder specificity of impulsivity in pathological gambling. ADDICT BEHAV 2014;39 (11):1646-1651 [PubMed]
Merkx MJM, Schippers GM, Koeter MWJ, de Wildt WAJM, Vedel E, Goudriaan AE, van den Brink W, Treatment outcome of alcohol use disorder outpatients with or without medically assisted detoxification. J STUD ALCOHOL DRUGS 2014;75 (6):993-998 [PubMed]
Romanczuk-Seiferth N, van den Brink W, Goudriaan AE, From symptoms to neurobiology: pathological gambling in the light of the new classification in DSM-5. NEUROPSYCHOBIOLOGY 2014;70 (2):95-102 [PubMed]
Schmaal L, Goudriaan AE, Joos L, Dom G, Pattij T, van den Brink W, Veltman DJ, Neural substrates of impulsive decision making modulated by modafinil in alcohol-dependent patients. PSYCHOL MED 2014;44 (13):2787-2798 [PubMed]
Schulte MHJ, Cousijn J, den Uyl TE, Goudriaan AE, van den Brink W, Veltman DJ, Schilt T, Wiers RW, Recovery of neurocognitive functions following sustained abstinence after substance dependence and implications for treatment. CLIN PSYCHOL REV 2014;34 (7):531-550 [PubMed]
Stevens L, Verdejo-García A, Goudriaan AE, Roeyers H, Dom G, Vanderplasschen W, Impulsivity as a vulnerability factor for poor addiction treatment outcomes: a review of neurocognitive findings among individuals with substance use disorders. J SUBST ABUSE TREAT 2014;47 (1):58-72 [PubMed]
Vanes LD, van Holst RJ, Jansen JM, van den Brink W, Oosterlaan J, Goudriaan AE, Contingency learning in alcohol dependence and pathological gambling: learning and unlearning reward contingencies. ALCOHOL CLIN EXP RES 2014;38 (6):1602-1610 [PubMed]
van Holst RJ, Clark L, Veltman DJ, van den Brink W, Goudriaan AE, Enhanced striatal responses during expectancy coding in alcohol dependence. DRUG ALCOHOL DEPEN 2014;142:204-208 [PubMed]
Zaaijer ER, Bruijel J, Blanken P, Hendriks V, Koeter MWJ, Kreek MJ, Booij J, Goudriaan AE, van Ree JM, van den Brink W, Personality as a risk factor for illicit opioid use and a protective factor for illicit opioid dependence. DRUG ALCOHOL DEPEN 2014;145:101-105 [PubMed]
Blanco CE, Blaszczynski A, Clement R, Derevensky J, Goudriaan AE, Hodgins DC, van Holst RJ, Ibáñez A, Martins SS, Moersen C, Molinaro S, Parke A, Peren FW, Petry NM, Wardle H, Assessment Tool to Measure and Evaluate the Risk Potential of Gambling Products, ASTERIG: A Global Validation. GAMING LAW REV ECON 2013;17 (9):635-642
Boog M, Goudriaan AE, van de Wetering BJM, Deuss H, Franken IHA, The concepts of rash impulsiveness and reward sensitivity in substance use disorders. EUR ADDICT RES 2013;19 (5):261-268 [PubMed]
Cousijn J, Goudriaan AE, Ridderinkhof KR, van den Brink W, Veltman DJ, Wiers RW, Neural responses associated with cue-reactivity in frequent cannabis users. ADDICT BIOL 2013;18 (3):570-580 [PubMed]
Cousijn J, Watson P, Koenders L, Vingerhoets WAM, Goudriaan AE, Wiers RW, Cannabis dependence, cognitive control and attentional bias for cannabis words. ADDICT BEHAV 2013;38 (12):2825-2832 [PubMed]
Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Porrino LJ, Goudriaan AE, Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study. ADDICT BIOL 2013;18 (6):1013-1023 [PubMed]
de Wilde B, Goudriaan A, Sabbe B, Hulstijn W, Dom G, Relapse in pathological gamblers: A pilot study on the predictive value of different impulsivity measures. J BEHAV ADDICT 2013;2 (1):23-30 [PubMed]
Fineberg NA, Baldwin DS, Menchon JM, Denys D, Grünblatt E, Pallanti S, Stein DJ, Zohar J [Contributors: Alonso P, Andreewitch S, Baldwin D, Bellodi L, Bersani G, Cath D, Chamberlain S, Clark L, Craig K, Denys D, dell'Osso B, Eilam D, Fineberg N, Goudriaan Anna E, Grünblatt E, Hermesh H, Heyman I, Hollander E, Hranov G, Hranov L, Ivarsson T, Joel D, Matthews K, Lochner C, Marazziti D, Mataix-Cols D, Menchon J, Noldus L, Pallanti S, Robbins T, Romanos M, Renner T, Rück C, Sahakian B, Stein D, van den Brink W, van den Heuvel O, van der Wee N, Veltman D, Walitza S, Zohar J]] , Manifesto for a European research network into obsessive-compulsive and related disorders. EUR NEUROPSYCHOPHARM 2013;23 (7):561-568 [PubMed]
Goudriaan AE, Veltman DJ, van den Brink W, Dom G, Schmaal L, Neurophysiological effects of modafinil on cue-exposure in cocaine dependence: a randomized placebo-controlled cross-over study using pharmacological fMRI. ADDICT BEHAV 2013;38 (2):1509-1517 [PubMed]
Jansen JM, Daams JG, Koeter MWJ, Veltman DJ, van den Brink W, Goudriaan AE, Effects of non-invasive neurostimulation on craving: a meta-analysis. NEUROSCI BIOBEHAV R 2013;37 (10 Part 2):2472-2480 [PubMed]
Joos L. Impulsivity: a treatable risk factor in relapse to alcohol dependence. s.l.: s.n.; 2013. 215p. Proefschrift Universiteit Antwerpen, Geneeskunde. (Promotor(s): Dom G, Sabbe B; copromotor(s): Goudriaan AE)
Joos L, Goudriaan AE, Schmaal L, de Witte NAJ, van den Brink W, Sabbe BGC, Dom G, The relationship between impulsivity and craving in alcohol dependent patients. PSYCHOPHARMACOLOGY 2013;226 (2):273-283 [PubMed]
Joos L, Goudriaan AE, Schmaal L, Fransen E, van den Brink W, Sabbe BGC, Dom G, Effect of modafinil on impulsivity and relapse in alcohol dependent patients: a randomized, placebo-controlled trial. EUR NEUROPSYCHOPHARM 2013;23 (8):948-955 [PubMed]
Joos L, Goudriaan AE, Schmaal L, van den Brink W, Sabbe BGC, Dom G, Effect of modafinil on cognitive functions in alcohol dependent patients: a randomized, placebo-controlled trial. J PSYCHOPHARMACOL 2013;27 (11):998-1006 [PubMed]
Joos L, Schmaal L, Broos N, Goudriaan AE, Modafinil bij alcoholafhankelijke patiënten: het effect op terugval. TIJDSCHR PSYCHIATR 2013;55 (11):879-884 [PubMed]
Joos L, Schmaal L, Goudriaan AE, Fransen E, van den Brink W, Sabbe BGC, Dom G, Age of onset and neuropsychological functioning in alcohol dependent inpatients. ALCOHOL CLIN EXP RES 2013;37 (3):407-416 [PubMed]
Menossi HS, Goudriaan AE, de Azevedo-Marques Périco C, Nicastri S, de Andrade AG, D'Elia G, Li CSR, Castaldelli-Maia JM, Neural bases of pharmacological treatment of nicotine dependence - insights from functional brain imaging: a systematic review. CNS DRUGS 2013;27 (11):921-941 [PubMed]
Schmaal L. Boosting impulse control in addiction. Pharmacological neuroimaging studies. s.l.: s.n.; 2013. 259p. ISBN 9789088915437 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van den Brink W, Veltman DJ; copromotor(s): Goudriaan AE, Dom G)
Schmaal L, Broos N, Joos L, Pattij T, Goudriaan AE, Impulsregulatie en verslaving: een translationeel onderzoek. TIJDSCHR PSYCHIATR 2013;55 (11):823-831 [PubMed]
Schmaal L, Goudriaan AE, Joos L, Krüse AM, Dom G, van den Brink W, Veltman DJ, Modafinil modulates resting-state functional network connectivity and cognitive control in alcohol-dependent patients. BIOL PSYCHIAT 2013;73 (8):789-795 [PubMed]
Schmaal L, Joos L, Koeleman M, Veltman DJ, van den Brink W, Goudriaan AE, Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients. BIOL PSYCHIAT 2013;73 (3):211-218 [PubMed]
Starcke K, van Holst RJ, van den Brink W, Veltman DJ, Goudriaan AE, Physiological and endocrine reactions to psychosocial stress in alcohol use disorders: duration of abstinence matters. ALCOHOL CLIN EXP RES 2013;37 (8):1343-1350 [PubMed]
van den Bos R, Davies W, Dellu-Hagedorn F, Goudriaan AE, Granon S, Homberg J, Rivalan M, Swendsen J, Adriani W, Cross-species approaches to pathological gambling: a review targeting sex differences, adolescent vulnerability and ecological validity of research tools. NEUROSCI BIOBEHAV R 2013;37 (10 Part 2):2454-2471 [PubMed]
Brevers D, Cleeremans A, Goudriaan AE, Bechara A, Kornreich C, Verbanck P, Noël X, Decision making under ambiguity but not under risk is related to problem gambling severity. PSYCHIAT RES 2012;200 (2-3):568-574 [PubMed]
Broos N, Schmaal L, Wiskerke J, Kostelijk L, Lam T, Stoop N, Weierink L, Ham J, de Geus EJC, Schoffelmeer ANM, van den Brink W, Veltman DJ, de Vries TJ, Pattij T, Goudriaan AE, The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study. PLOS ONE 2012;7 (5):e36781 [PubMed]
Cousijn J. A joint approach: brain structure & function in heavy cannabis users & their relationship with future use. s.l.: s.n.; 2012. 184p. Proefschrift Universiteit van Amsterdam, FMG. (Promotor(s): Wiers RW; copromotor(s): Goudriaan AE)
Cousijn J, Goudriaan AE, Ridderinkhof KR, van den Brink W, Veltman DJ, Wiers RW, Approach-Bias Predicts Development of Cannabis Problem Severity in Heavy Cannabis Users: Results from a Prospective FMRI Study. PLOS ONE 2012;7 (9):e42394 [PubMed]
Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Goudriaan AE, Grey matter alterations associated with cannabis use: Results of a VBM study in heavy cannabis users and healthy controls. NEUROIMAGE 2012;59 (4):3845-3851 [PubMed]
de Ruiter MB, Oosterlaan J, Veltman DJ, van den Brink W, Goudriaan AE, Similar hyporesponsiveness of the dorsomedial prefrontal cortex in problem gamblers and heavy smokers during an inhibitory control task. DRUG ALCOHOL DEPEN 2012;121 (1-2):81-89 [PubMed]
Goudriaan A, DeFuentes-Merillas L. Pathologisch gokken in: Franken I, Muris P, Denys D, editors. Basisboek psychopathologie. Utrecht: De Tijdstroom; 2012., p. 709-724
Goudriaan AE, Sher KJ. Alcohol in: Verster JC, Brady K, Galanter M, Conrod P, editors. Drug Abuse and Addiction in Medical Illness: Causes, Consequences and Treatment. Berlin: Springer; 2012., p. 123-136
Goudriaan AE, van Holst RJ, Veltman DJ, van den Brink W. Neuroscience of Pathological Gambling in: Richard D, Blaszczynski A, Nower L, editors. Handbook of Pathological Gambling. S.l.: Wiley-Blackwell; 2012., p. -
Schierenberg A, van Amsterdam J, van den Brink W, Goudriaan AE, Efficacy of contingency management for cocaine dependence treatment: a review of the evidence. CURR DRUG ABUSE REV 2012;5 (4):320-331 [PubMed]
Schmaal L, Goudriaan AE, Meer J, Brink W, Veltman DJ, The association between cingulate cortex glutamate concentration and delay discounting is mediated by resting state functional connectivity. BRAIN BEHAV 2012;2 (5):553-562 [PubMed]
Schmaal L, Veltman DJ, Nederveen A, van den Brink W, Goudriaan AE, N-Acetylcysteine Normalizes Glutamate Levels in Cocaine-Dependent Patients: A Randomized Crossover Magnetic Resonance Spectroscopy Study. NEUROPSYCHOPHARMACOL 2012;37 (9):2143-2152 [PubMed]
van Holst RJ, de Ruiter MB, van den Brink W, Veltman DJ, Goudriaan AE, A voxel-based morphometry study comparing problem gamblers, alcohol abusers, and healthy controls. DRUG ALCOHOL DEPEN 2012;124 (1-2):142-148 [PubMed]
van Holst RJ, Lemmens JS, Valkenburg PM, Peter J, Veltman DJ, Goudriaan AE, Attentional Bias and Disinhibition Toward Gaming Cues Are Related to Problem Gaming in Male Adolescents. J ADOLESCENT HEALTH 2012;50 (6):541-546 [PubMed]
van Holst RJ, van der Meer JN, McLaren DG, van den Brink W, Veltman DJ, Goudriaan AE, Interactions between Affective and Cognitive Processing Systems in Problematic Gamblers: A Functional Connectivity Study. PLOS ONE 2012;7 (11):e49923 [PubMed]
van Holst RJ, van Holstein M, van den Brink W, Veltman DJ, Goudriaan AE, Response Inhibition during Cue Reactivity in Problem Gamblers: An fMRI Study. PLOS ONE 2012;7 (3):e30909 [PubMed]
van Holst RJ, Veltman DJ, Büchel C, van den Brink W, Goudriaan AE, Distorted Expectancy Coding in Problem Gambling: Is the Addictive in the Anticipation?. BIOL PSYCHIAT 2012;71 (8):741-748 [PubMed]
van Holst RJ, Veltman DJ, van den Brink W, Goudriaan AE, Right on Cue? Striatal Reactivity in Problem Gamblers. BIOL PSYCHIAT 2012;72 (10):E23-E24 [PubMed]
Cousijn J, Goudriaan AE, Wiers RW, Reaching out towards cannabis: approach-bias in heavy cannabis users predicts changes in cannabis use. ADDICTION 2011;106 (9):1667-1674 [PubMed]
Goudriaan AE, Grekin ER, Sher KJ, Decision making and response inhibition as predictors of heavy alcohol use: a prospective study. ALCOHOL CLIN EXP RES 2011;35 (6):1050-1057 [PubMed]
van Holst RJ. Imagingstudies in pathological gambling: similarities and differences with alcohol dependence. s.l.: s.n.; 2011. 238p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van den Brink W, Veltman DJ; copromotor(s): Goudriaan AE)
Goudriaan AE, de Ruiter MB, van den Brink W, Oosterlaan J, Veltman DJ, Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. ADDICT BIOL 2010;15 (4):491-503 [PubMed]
Goudriaan AE, Lapauw B, Ruige J, Feyen E, Kaufman JM, Brand M, Vingerhoets G, The influence of high-normal testosterone levels on risk-taking in healthy males in a 1-week letrozole administration study. PSYCHONEUROENDOCRINO 2010;35 (9):1416-1421 [PubMed]
van Holst RJ, van den Brink W, Veltman DJ, Goudriaan AE, Brain Imaging Studies in Pathological Gambling. CURR PSYCHIAT REP 2010;12 (5):418-425 [PubMed]
van Holst RJ, van den Brink W, Veltman DJ, Goudriaan AE, Why gamblers fail to win: a review of cognitive and neuroimaging findings in pathological gambling. NEUROSCI BIOBEHAV R 2010;34 (1):87-107 [PubMed]
de Ruiter MB, Veltman DJ, Goudriaan AE, Oosterlaan J, Sjoerds Z, van den Brink W, Response Perseveration and Ventral Prefrontal Sensitivity to Reward and Punishment in Male Problem Gamblers and Smokers. NEUROPSYCHOPHARMACOL 2009;34 (4):1027-1038 [PubMed]
Goudriaan AE, de Bruin D, Koeter MW. Netherlands in: Meyer G, Hayer T, Griffiths M, editors. Problem Gambling in Europe: Extent and Preventive Efforts. New York: Springer; 2008., p. -
Goudriaan AE, Slutske WS, Krull JL, Sher KJ, Longitudinal patterns of gambling activities and associated risk factors in college students. ADDICTION 2009;104 (7):1219-1232 [PubMed]
Schilt T, Goudriaan AE, Koeter MW, van den Brink W, Schmand B, Decision making as a predictor of first ecstasy use: a prospective study. PSYCHOPHARMACOLOGY 2009;203 (3):519-527 [PubMed]
Baas JMP, van Ooijen L, Goudriaan A, Kenemans JL, Failure to condition to a cue is associated with sustained contextual fear. ACTA PSYCHOL 2008;127 (3):581-592 [PubMed]
Goudriaan AE. Pathologisch gokken in: Handboek verslaving. S.l.: s.n.; 2002., p. -
Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W, The role of self-reported impulsivity and reward sensitivity versus neurocognitive measures of disinhibition and decision-making in the prediction of relapse in pathological gamblers. PSYCHOL MED 2008;38 (1):41-50 [PubMed]
Goudriaan AE, Grekin ER, Sher KJ, Decision making and binge drinking: a longitudinal study. ALCOHOL CLIN EXP RES 2007;31 (6):928-938 [PubMed]
Smeding HMM, Goudriaan AE, Foncke EMJ, Schuurman PR, Speelman JD, Schmand B, Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease. J NEUROL NEUROSUR PS 2007;78 (5):517-519 [PubMed]
van den Brink W, DeFuentes-Merillas L, Goudriaan A, Koeter M. Pathologisch gokken in: Denys D, de Geus F, editors. Handboek obsessieve-compulsieve stoornissen. Utrecht: De Tijdstroom; 2007., p. 289-305
Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W, Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls. ADDICTION 2006;101 (4):534-547 [PubMed]
Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W, Psychophysiological determinants and concomitants of deficient decision making in pathological gamblers. DRUG ALCOHOL DEPEN 2006;84 (3):231-239 [PubMed]
Goudriaan AE. Self-regulation in pathological gambling and related disorders: a neurocognitive and psychophysiological investigation. S.l.: s.n.; 2005. 195p. ISBN 242224 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van den Brink W; copromotor(s): de Beurs E, Oosterlaan J)
Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W, Decision making in pathological gambling: A comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls. COGNITIVE BRAIN RES 2005;23 (1):137-151 [PubMed]
Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W, Pathological gambling: a comprehensive review of biobehavioral findings. NEUROSCI BIOBEHAV R 2004;28 (2):123-141 [PubMed]
Key publications

Jansen JM, Daams JG, Koeter MWJ, Veltman DJ, van den Brink W, Goudriaan AE, Effects of non-invasive neurostimulation on craving: a meta-analysis. NEUROSCI BIOBEHAV R 2013;37 (10 Part 2):2472-2480 [PubMed]
van Holst RJ, Veltman DJ, Büchel C, van den Brink W, Goudriaan AE, Distorted Expectancy Coding in Problem Gambling: Is the Addictive in the Anticipation?. BIOL PSYCHIAT 2012;71 (8):741-748 [PubMed]
Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Goudriaan AE, Grey matter alterations associated with cannabis use: Results of a VBM study in heavy cannabis users and healthy controls. NEUROIMAGE 2012;59 (4):3845-3851 [PubMed]
Schmaal L, Veltman DJ, Nederveen A, van den Brink W, Goudriaan AE, N-Acetylcysteine Normalizes Glutamate Levels in Cocaine-Dependent Patients: A Randomized Crossover Magnetic Resonance Spectroscopy Study. NEUROPSYCHOPHARMACOL 2012;37 (9):2143-2152 [PubMed]
Schmaal L, Joos L, Koeleman M, Veltman DJ, van den Brink W, Goudriaan AE, Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients. BIOL PSYCHIAT 2013;73 (3):211-218 [PubMed]


All Publications

Curriculum Vitae

Professional Memberships (selection)

2004 – present Member of the Cognitive Neuroscience Society (CNS).
2005 – present Member of the Research Society on Alcoholism (RSA).
2007 – present Member of the Research Institute for Experimental Psychology (EPOS).
2008 – current Member of the Organisation for Human Brain Mapping
2008 – current Full Member European College for Neuropsychopharmacology (ECNP)

Co-promotor of PhD students

- Ruth van Holst (AMC Psychiatry; 2007-2011; promotion date: 16 Sept 2011)
- Janna Cousijn (UvA Psychology; 2008-2012; promotion date: 30 November 2012)
- Lianne Schmaal (AMC Psychiatry; 2008-2012; promotion date: 11 January 2013)
- Leen Joos (University of Antwerp; CAPRI; promotion data: 25 June 2013)

- Eline Zaaijer (AMC; 2011-2014; promotion date: 24 september 2015)

Promotor of PhD students

- Jochem Jansen (AMC Psychiatry (2011- 2016; promotion date: 22 april 2016)

 

Education

University: Radboud University Nijmegen
Date (dd/mm/yy): 31/10/2000
Study/main subject: Neuropsychology and Rehabilitation Psychology (MA)

Doctorate/PhD
University/College of Higher Education: University of Amsterdam
Date: 18/11/2005 (Cum Laude)
Title of thesis: Self-regulation in pathological gambling and related disorders: A neurocognitive and psychophysiological investigation

Appointments

2012-current: Principal Investigator Addiction Research Arkin-AMC (PI)
2012-current: Psychologist (Cognitive Behaviour Therapy)
2011-2012: Senior Researcher AMC-postdoctoral fellowship (PI: Changing the vulnerable brain in addiction: an rTMS project)
2007-2011: Postdoctoral Researcher: ZonMw Veni grant (PI: Looking for reward or running away from stress and dysphoria)
2006-2007: Postdoc New Investigator Grant (PI; Institute for Research on Gambling; awarded by Harvard Medical School; University of Missouri)
2005-2006: Postdoctoral fellow University of Missouri (Alcohol, Health, Behavior Lab; prof. Kenneth Sher)
 

Scholarships, grants and prizes

- NCRG Scientific Achievement Award – Young Investigator (2009). Awarded two-yearly.
- American Psychological Association (APA) Division 50 (Addictions) Presentation Award 2009 (APA Convention 2009).
- Poster Awards: European College on Neuropsychopharmacology 2010; Institute for Research on Problem Gambling 2006.
- Travel Award poster presentations: Research Society on Alcoholism (RSA) 2006, 2007; NIDA-CPDD meeting 2011; Miami, USA.
- Principal Investigator: application and admittance as Principal Investigator by the Research Council of the Academic Medical Center (AMC); September 2011.

- Experimental Psychopathology (EPP) Research School PhD student grant: Mieke ter Mors-Schulte (AMC-UvA). June 2012. Amount €200.000,-.
- NWO/ZonMW and NIDA binational Research grant (2009 – Co-PI Dutch project part): Slow-release Naltrexone as a new potential treatment for opiate dependent patients: a questionnaire study into treatment acceptability in patients and clinicians, and a feasibility study. Start project: February 2011); Amount €100.000,-.
- Full proposal European Alcohol Research Foundation (ERAB; PI): Changing the vulnerable brain: a neuromodulation study in alcohol dependence. Funded, November 2010: PI on project; €100.000,-.
- AMC Postdoctoral Fellowship (PI): A neuromodulation-neuroimaging study in alcohol dependence. Funded, March 2010, Start project: January 2011; €150.000,-.
- NWO/ZonMW and NIDA binational Research grant (2007 – PI Dutch project part): Cannabis use: neurobiological risk factors for dependence; (Dutch Scientific Society (NWO; Netherlands and National Institute for Drug Abuse Research (NIDA; USA), Amount €100.000,-.
- NWO/ZonMw “Risky Behavior and Dependence” Program Grant (2007; Co-PI with D.J. Veltman, Ph.D., W. van den Brink, M.D., Ph.D., G. Dom, M.D., Ph.D.) Impulsivity: a treatable risk factor in addiction? (Dutch Scientific Society: ZonMw), Amount €750.000,-.
- Institute for Research on Pathological Gambling and Related Disorders New Investigator Grant (June 2006- PI): Gambling patterns and changes over time in a college sample: a longitudinal study. Awarded by the Division of Addictions, Harvard Medical School; Amount: $53.000,-.
- Veni grant, Dutch Scientific Society-NWO, ZonMw (January 2006-PI): Looking for reward or running away from stress and dysphoria: different vulnerabilities and pathways to addictive behaviors. Postdoctoral 3-year research grant (2007-2011). Amount: €208.000,-.
- ZonMw Grant, Addiction Program (2003 – Co-PI). Pathogenic mechanisms in pathological gambling: An fMRI study into deficient self-regulation. Amount: €169.000,-


Review and editorial tasks (selection)
- Editorial Board Member: Current Drug Abuse Reviews; Open Addiction Journal
- Associate Editor: Journal of Behavioral Addictions
- Reviewer: Addiction; Alcoholism, Clinical and Experimental Research; Biological Psychiatry; Brain; Drug and Alcohol Dependence; European Addiction Research; European Journal of Neuropsycho-pharmacology; Journal of Behavioral Addictions; Journal of Gambling Research; Neuroimage; Neuropsychologia; Neuroscience and Biobehavioral Reviews; Psychiatry Research: Neuroimaging; Psychological Medicine; Psychology of Addictive Behaviors.
- Grant reviewer: NWO-ZonMw, ERAB (European Foundation for Alcohol Research), Australian Science Foundation; Fondation National de Recherche Scientifique (FNRS; Belgium).

Academic Teaching Experience
Starting during my Ph.D., up till now, I have taught a variety of courses, from basic scientific skills teaching, to highly specialised courses at the research master level, and from large scale lectures to interactive workgroups: practical neuropsychology; case report supervision groups (neuropsychology): courses in addiction, in scientific research and writing skills; general tutoring of bachelor students; supervising of over 20 master thesis students.
Lectures and courses for students (selection):
- AMC Medicine Masters; Universiteit Utrecht: Social Sciences Bachelors (coordination: R. van den Eijnden); PhD Summer Institute University of Amsterdam); Amsterdam University College Bachelors; AMC Masters Psychobiology: UvA Masters pedagogiek: (coordination: Prof. A. Huizink); Postdoctoral GZ-courses Addiction (Cure & Care, RINO); VU Clinical Neuropsychology Master; VU Medicine.
 

Research programmes

Neurobiological mechanisms of action and treatment effects in addictive disorders

Neuroimaging and neurocognitive studies of behavioral addiction: comparability to substance dependence

Impulsivity and reward sensitivity as neurobiological markers of addiction

Psychopharmacological studies in substance dependence: alcohol dependence, cocaine dependence, heroin dependence

Studying the therapeutical mechanisms of action of cognitive enhancers and opioid antagonists through neuroimaging

Epidemiology of problem gambling behaviors in young adults

Cognitive-motivational mechanisms underlying increasing or decreasing cannabis use in at-risk young adult users

 

Faculty
Prof. dr. A.E. Goudriaan (Arkin)

Postdocs
Dr. M. Blankers (Arkin)
Dr. J. Cousijn (University of Utrecht)
R.J. van Holst PhD (Cambridge University, Department of Experimental Psychology)
Dr. M.J. Kikkert (Arkin)
Dr. G.H. de Weert-van Oene (Arkin, Jellinek)

PhD Students
R.S. Schluter MSc
Drs. M. Termors-Schulte (University of Amsterdam, Dept. Psychology)
T. van Timmeren
Drs. M. de Waal (Arkin Mental Health)
S. Bakelaar MA (University of Stellenbosch, South Africa)
E. Beraha Menahem MA (University of Amsterdam, Dept. Psychology)
Drs. M. Boog (Bouman Verslavingszorg, Rotterdam)

Others
E. Asperslag MA (Arkin, Jellinek)
Drs. N. Lommerse

Prof. dr. W. van den Brink MD PhD (Addiction: pathogenesis, mechanisms of relapse and treatment effectiveness)

Other research related activities
  • Membership of editorial board / Editorship, PSYCHOLOGY OF ADDICTIVE BEHAVIORS
  • Membership of editorial board / Editorship, JOURNAL OF GAMBLING STUDIES
  • Membership of editorial board / Editorship, CURRENT DRUG ABUSE REVIEWS
  • Member of Editorial Board, The Journal of Behavioral Addictions
  • Membership of editorial board, The Open Addiction Journal
  • Membership of advisory board / Consultant, Amsterdam Brain and Cognition (ABC) Program University of Amsterdam
  • Membership of advisory board / Consultant, Ministry of Justice
  • Member of Scientific Program Committee, Endo-Neuro-Psycho (ENP) Meeting - Neurofederatie, NVN, NVP
  • Membership of medical or scientific committee, University of Melbourne, Member of PhD Examination Committee (PhD Candidate: Valentina Lorenzetti - effects of regular cannabis use on human brain structure)
  • Membership of medical or scientific committee, University of Bergen, Norway, Doctoral defense committee (PhD candidate: Geir Scott Brunborg)
  • Contribution to training of professionals, Cure and Care
Current research funding
  • AMC
  • Stichting Arkin
  • TUV INTERCERT GmbH (Group of TUV Saarland)
  • ZonMw