• Principal Investigator
  • Female

Prof. E.M.A. Aronica

Position: Professor
Main activities: Patient care, Research, Teaching
Specialisation: Neuropathology
foto E.M.A. Aronica is one of the AMC Principal Investigators
Focus of research:
  • Epilepsy
  • Inflammation
  • Neurodevelopmental disorders
  • Brain development and ageing
  • Neuroncology
  • Neuromusculaire ziekten  

The research group headed by Aronica is involved in different research lines in neuropathology (neurodegenerative disorders, neuro-oncology and epilepsy), establishing national and international collaboration. In particular we focused on the role of neuron-glia interactions in brain function and pathology. We address three pivotal scientific objectives of current international interest: 1. Identifying and defining novel molecular and cellular pathways of bidirectional communication between neurons and glia in the developing and the adult brain 2. Defining alterations of neuron-glia interactions in the diseased brain using epilepsy as a central paradigm (complex brain disorder exhibiting a variety of pathological events also seen in other CNS diseases) 3. Developing better research instrumentation, novel drug screening and evaluation assays and disease models to reveal the diversity of neuron-glia interactions in the healthy and the epileptic brain. The research has been focused on the search for effective treatment for patients with epilepsy by delineating the biological and molecular pathways that contribute to development and progression of epilepsy (epileptogenesis) in patients with focal epilepsy, including patients with malformations of cortical development (MCD). The research group has contribute to the identification of key pathways involved in the pathogenesis of a large spectrum of MCD. Moreover, we provided evidence of a prominent and persistent activation of the innate immune response in various neurological disorders with different etiologies, but without a primary inflammatory pathogenesis. This response involves both astrocytes and microglial cells and is associated with the activation of several pathways which influence hyperexcitability and degeneration. Looking for an effective disease-modifying therapies targeting pathologic neuroinflammation, we studied the upstream control mechanism this process focusing on a family of non-coding RNAs (microRNAs) acting as key post-transcriptional modulators of the innate immune response and as novel disease biomarkers.

AMC themes: Neurological & Psychiatric Disorders, Public Health & Epidemiology
Departments: Pathology
Arena A, Iyer AM, Milenkovic I, Kovacs GG, Ferrer I, Perluigi M, Aronica E, Developmental Expression and Dysregulation of miR-146a and miR-155 in Down's Syndrome and Mouse Models of Down's Syndrome and Alzheimer's Disease. CURR ALZHEIMER RES 2017;14 (12):1305-1317 [PubMed]
Aronica E, Bauer S, Bozzi Y, Caleo M, Dingledine R, Gorter JA, Henshall DC, Kaufer D, Koh S, Löscher W, Louboutin JP, Mishto M, Norwood BA, Palma E, Poulter MO, Terrone G, Vezzani A, Kaminski RM, Neuroinflammatory targets and treatments for epilepsy validated in experimental models. EPILEPSIA 2017;58 (Suppl. 3):27-38 [PubMed]
Aronica E, Mühlebner A, Neuropathology of epilepsy. HANDB CLIN NEUROL 2017;145:193-216 [PubMed]
Barth PG, Aronica E, Fox S, Fluiter K, Weterman MAJ, Poretti A, Miller DC, Boltshauser E, Harding B, Santi M, Baas F, Deregulated expression of EZH2 in congenital brainstem disconnection. NEUROPATH APPL NEURO 2017;43 (4):358-365 [PubMed]
Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G [Contributors: Aparicio J, Bento C, Beckervordersandforth J, Buccoliero A, Cabral P, Chamadoira C, Colon A, Chabardès S, Carpenter S, Czech T, Dressler A, Deleo F, Dílio A, Dings J, Devaux B, de Tisi J, de Bellescize J, Ebner A, Franke K, Groeppel G, Giordano F, Gozzo F, Garbelli R, Guenot M, García‐Morales I, Gómez‐Angulo JC, Garcia G, Hainfellner JA, Höfler J, Hoogland G, Hendriks M, Hofman P, Harding B, Huppertz HJ, Herms J, Hilkman DMW, Hamelin S, Idema S, Jansen FE, Jahodova A, Keeley A, Kalss G, Kudr M, Kroell J, Kokkinos V, Keo Kosal P, Kalbhenn T, Leitinger M, Landré E, Melo Pires M, Matas A, Mann MW, Ostrowsky‐Coste K, Prinz M, Puttinger G, Peraud A, Rangel Pinho R, Romero C, Rego R, Rouhl R, Ryvlin P, Rumia J, Rampp S, Scholl T, Schulz R, Stone TJ, Streichenberger N, Tisdall M, Turak B, Taipa R, Uzan M, van Kranen‐Mastenbroek V, Varlet P, Vlooswijk M, Wagner L, Weis S]] , Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. NEW ENGL J MED 2017;377 (17):1648-1656 [PubMed]
Bonaventura G, Iemmolo R, D'Amico AG, La Cognata V, Costanzo E, Zappia M, D'Agata V, Conforti FL, Aronica E, Cavallaro S, PACAP and PAC1R are differentially expressed in motor cortex of amyotrophic lateral sclerosis patients and support survival of iPSC-derived motor neurons. J CELL PHYSIOL 2017;ahead of print [PubMed]
Broekaart DWM, van Scheppingen J, Geijtenbeek KW, Zuidberg MRJ, Anink JJ, Baayen JC, Mühlebner A, Aronica E, Gorter JA, van Vliet EA, Increased expression of (immuno) proteasome subunits during epileptogenesis is attenuated by inhibition of the mammalian target of rapamycin pathway. EPILEPSIA 2017;58 (8):1462-1472 [PubMed]
Bugiani M, van Zanten SEMV, Caretti V, Schellen P, Aronica E, Noske DP, Vandertop WP, Kaspers GJL, van Vuurden DG, Wesseling P, Hulleman E, Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma. ONCOTARGET 2017;8 (36):60447-60452 [PubMed]
Dreser A, Vollrath JT, Sechi A, Johann S, Roos A, Yamoah A, Katona I, Bohlega S, Wiemuth D, Tian Y, Schmidt A, Vervoorts J, Dohmen M, Beyer C, Anink J, Aronica E, Troost D, Weis J, Goswami A, The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins. CELL DEATH DIFFER 2017;24 (10):1655-1671 [PubMed]
Engelen-Lee J, Blokhuis AM, Spliet WGM, Pasterkamp RJ, Aronica E, Demmers JAA, Broekhuizen R, Nardo G, Bovenschen N, van den Berg LH, Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis. AMYOTROPH LAT SCL FR 2017;18 (3-4):210-220 [PubMed]
Iori V, Iyer AM, Ravizza T, Beltrame L, Paracchini L, Marchini S, Cerovic M, Hill C, Ferrari M, Zucchetti M, Molteni M, Rossetti C, Brambilla R, Steve White H, D'Incalci M, Aronica E, Vezzani A, Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy. NEUROBIOL DIS 2017;99:12-23 [PubMed]
Korotkov A, Mills JD, Gorter JA, van Vliet EA, Aronica E, Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy. SCI REP-UK 2017;7 (1):11592 [PubMed]
Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A, Common data elements and data management: Remedy to cure underpowered preclinical studies. EPILEPSY RES 2017;129:87-90 [PubMed]
Milenkovic I, Jarc J, Dassler E, Aronica E, Iyer A, Adle-Biassette H, Scharrer A, Reischer T, Hainfellner JA, Kovacs GG, The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome. NEUROPATH APPL NEURO 2017;ahead of print [PubMed]
Mills JD, Iyer AM, van Scheppingen J, Bongaarts A, Anink JJ, Janssen B, Zimmer TS, Spliet WG, van Rijen PC, Jansen FE, Feucht M, Hainfellner JA, Krsek P, Zamecnik J, Kotulska K, Jozwiak S, Jansen A, Lagae L, Curatolo P, Kwiatkowski DJ, Pasterkamp RJ, Senthilkumar K, von Oerthel L, Hoekman MF, Gorter JA, Crino PB, Mühlebner A, Scicluna BP, Aronica E, Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment. SCI REP-UK 2017;7 (1):8089 [PubMed]
Mir SE, Smits M, Biesmans D, Julsing M, Bugiani M, Aronica E, Kaspers GJL, Cloos J, Würdinger T, Hulleman E, Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma. ONCOTARGET 2017;8 (45):78978-78988 [PubMed]
Palma E, Ruffolo G, Cifelli P, Roseti C, van Vliet EA, Aronica E, Modulation of GABAA receptors in the treatment of epilepsy. CURR PHARM DESIGN 2017;ahead of print [PubMed]
Pauletti A, Terrone G, Shekh-Ahmad T, Salamone A, Ravizza T, Rizzi M, Pastore A, Pascente R, Liang LP, Villa BR, Balosso S, Abramov AY, van Vliet EA, del Giudice E, Aronica E, Antoine DJ, Patel M, Walker MC, Vezzani A, Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy. BRAIN 2017;140 (7):1885-1899 [PubMed]
Rossini L, Villani F, Granata T, Tassi L, Tringali G, Cardinale F, Aronica E, Spreafico R, Garbelli R, FCD Type II and mTOR pathway: Evidence for different mechanisms involved in the pathogenesis of dysmorphic neurons. EPILEPSY RES 2017;129:146-156 [PubMed]
Scheldeman C, Mills JD, Siekierska A, Serra I, Copmans D, Iyer AM, Whalley BJ, Maes J, Jansen AC, Lagae L, Aronica E, de Witte PAM, mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. NEUROBIOL DIS 2017;108:225-237 [PubMed]
Scholl T, Mühlebner A, Ricken G, Gruber V, Fabing A, Samueli S, Gröppel G, Dorfer C, Czech T, Hainfellner JA, Prabowo AS, Reinten RJ, Hoogendijk L, Anink JJ, Aronica E, Feucht M, Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex. BRAIN PATHOL 2017;27 (6):770-780 [PubMed]
Thom M, Liu J, Bongaarts A, Reinten RJ, Paradiso B, Jäger HR, Reeves C, Somani A, An S, Marsdon D, McEvoy A, Miserocchi A, Thorne L, Newman F, Bucur S, Honavar M, Jacques T, Aronica E, MULTINODULAR AND VACUOLATING NEURONAL TUMOURS IN EPILEPSY: DYSPLASIA OR NEOPLASIA?. BRAIN PATHOL 2017;ahead of print [PubMed]
Tortarolo M, Lo Coco D, Veglianese P, Vallarola A, Giordana MT, Marcon G, Beghi E, Poloni M, Strong MJ, Iyer AM, Aronica E, Bendotti C, Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFα. MEDIAT INFLAMM 2017;2017:2985051 [PubMed]
van Dijk T, Rudnik-Schöneborn S, Senderek J, Hajmousa G, Mei H, Dusl M, Aronica E, Barth P, Baas F, Pontocerebellar hypoplasia with spinal muscular atrophy (PCH1): identification of SLC25A46 mutations in the original Dutch PCH1 family. BRAIN 2017;140 (8):E45-+ [PubMed]
van Vliet EA, Aronica E, Vezzani A, Ravizza T, Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies. NEUROPATH APPL NEURO 2017;ahead of print [PubMed]
van Vliet EA, Puhakka N, Mills JD, Srivastava PK, Johnson MR, Roncon P, Das Gupta S, Karttunen J, Simonato M, Lukasiuk K, Gorter JA, Aronica E, Pitkänen A, Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs. EPILEPSIA 2017;ahead of print [PubMed]
Weber JJ, Golla M, Guaitoli G, Wanichawan P, Hayer SN, Hauser S, Krahl AC, Nagel M, Samer S, Aronica E, Carlson CR, Schöls L, Riess O, Gloeckner CJ, Nguyen HP, Hübener-Schmid J, A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3. BRAIN 2017;140 (5):1280-1299 [PubMed]
Zhou X, Huang F, Xu L, Lin Z, de Vrij FMS, Ayo-Martin AC, van der Kroeg M, Zhao M, Yin Y, Wang W, Cao W, Wang Y, Kushner SA, Marie Peron J, Alric L, de Man RA, Jacobs BC, van Eijk JJ, Aronica EMA, Sprengers D, Metselaar HJ, de Zeeuw CI, Dalton HR, Kamar N, Peppelenbosch MP, Pan Q, Hepatitis E Virus Infects Neurons and Brains. J INFECT DIS 2017;215 (8):1197-1206 [PubMed]
Bahia El Idrissi N, Bosch S, Ramaglia V, Aronica E, Baas F, Troost D, Complement activation at the motor end-plates in amyotrophic lateral sclerosis. J NEUROINFLAMM 2016;13 (1):72 [PubMed]
Blokhuis AM, Koppers M, Groen EJN, van den Heuvel DMA, Dini Modigliani S, Anink JJ, Fumoto K, van Diggelen F, Snelting A, Sodaar P, Verheijen BM, Demmers JAA, Veldink JH, Aronica E, Bozzoni I, den Hertog J, van den Berg LH, Pasterkamp RJ, Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways. ACTA NEUROPATHOL 2016;132 (2):175-196 [PubMed]
Blümcke I, Aronica E, Becker A, Capper D, Coras R, Honavar M, Jacques TS, Kobow K, Miyata H, Mühlebner A, Pimentel J, Söylemezoğlu F, Thom M, Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification. NAT REV NEUROL 2016;12 (12):732-740 [PubMed]
Blümcke I, Aronica E, Miyata H, Sarnat HB, Thom M, Roessler K, Rydenhag B, Jehi L, Krsek P, Wiebe S, Spreafico R, International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods. EPILEPSIA 2016;57 (3):348-358 [PubMed]
Brambilla L, Guidotti G, Martorana F, Iyer AM, Aronica E, Valori CF, Rossi D, Disruption of the astrocytic TNFR1-GDNF axis accelerates motor neuron degeneration and disease progression in amyotrophic lateral sclerosis. HUM MOL GENET 2016;25 (14):3080-3095 [PubMed]
Businaro R, Corsi M, Azzara G, Di Raimo T, Laviola G, Romano E, Ricci L, Maccarrone M, Aronica E, Fuso A, Ricci S, Interleukin-18 modulation in autism spectrum disorders. J NEUROINFLAMM 2016;13 (1):2 [PubMed]
Curatolo P, Aronica E, Jansen A, Jansen F, Kotulska K, Lagae L, Moavero R, Jozwiak S, Early onset epileptic encephalopathy or genetically determined encephalopathy with early onset epilepsy? Lessons learned from TSC. EUR J PAEDIATR NEURO 2016;20 (2):203-211 [PubMed]
Denswil NP, van der Wal AC, Ritz K, de Boer OJ, Aronica E, Troost D, Daemen MJAP, Atherosclerosis in the circle of Willis: Spatial differences in composition and in distribution of plaques. ATHEROSCLEROSIS 2016;251:78-84 [PubMed]
Drion CM, Borm LE, Kooijman L, Aronica E, Wadman WJ, Hartog AF, van Vliet EA, Gorter JA, Effects of rapamycin and curcumin treatment on the development of epilepsy after electrically induced status epilepticus in rats. EPILEPSIA 2016;57 (5):688-697 [PubMed]
Engelen-Lee JY, Brouwer MC, Aronica E, van de Beek D, Pneumococcal meningitis: Clinical-pathological correlations (meningene-path). ACTA NEUROPATHOL COM 2016;4 (1):26 [PubMed]
Ferrer I, Garcia-Esparcia P, Carmona M, Carro E, Aronica E, Kovacs GG, Grison A, Gustincich S, Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease. FRONT AGING NEUROSCI 2016;8:163 [PubMed]
Fuso A, Iyer AM, van Scheppingen J, Maccarrone M, Scholl T, Hainfellner JA, Feucht M, Jansen FE, Spliet WG, Krsek P, Zamecnik J, Mühlebner A, Aronica E, Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC). J MOL NEUROSCI 2016;59 (4):464-470 [PubMed]
Gambardella A, Labate A, Cifelli P, Ruffolo G, Mumoli L, Aronica E, Palma E, Pharmacological modulation in mesial temporal lobe epilepsy: Current status and future perspectives. PHARMACOL RES 2016;113 (A):421-425 [PubMed]
Johann PD, Erkek S, Zapatka M, Kerl K, Buchhalter I, Hovestadt V, Jones DTW, Sturm D, Hermann C, Segura Wang M, Korshunov A, Rhyzova M, Gröbner S, Brabetz S, Chavez L, Bens S, Gröschel S, Kratochwil F, Wittmann A, Sieber L, Geörg C, Wolf S, Beck K, Oyen F, Capper D, van Sluis P, Volckmann R, Koster J, Versteeg R, von Deimling A, Milde T, Witt O, Kulozik AE, Ebinger M, Shalaby T, Grotzer M, Sumerauer D, Zamecnik J, Mora J, Jabado N, Taylor MD, Huang A, Aronica E, Bertoni A, Radlwimmer B, Pietsch T, Schüller U, Schneppenheim R, Northcott PA, Korbel JO, Siebert R, Frühwald MC, Lichter P, Eils R, Gajjar A, Hasselblatt M, Pfister SM, Kool M, Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. CANCER CELL 2016;29 (3):379-393 [PubMed]
Mills JD, Ward M, Chen BJ, Iyer AM, Aronica E, Janitz M, LINC00507 Is Specifically Expressed in the Primate Cortex and Has Age-Dependent Expression Patterns. J MOL NEUROSCI 2016;59 (4):431-439 [PubMed]
Mühlebner A, Iyer AM, van Scheppingen J, Anink JJ, Jansen FE, Veersema TJ, Braun KP, Spliet WGM, van Hecke W, Söylemezoğlu F, Feucht M, Krsek P, Zamecnik J, Bien CG, Polster T, Coras R, Blümcke I, Aronica E, Specific pattern of maturation and differentiation in the formation of cortical tubers in tuberous sclerosis omplex (TSC): evidence from layer-specific marker expression. J NEURODEV DISORD 2016;8:9 [PubMed]
Mühlebner A, van Scheppingen J, Hulshof HM, Scholl T, Iyer AM, Anink JJ, van den Ouweland AMW, Nellist MD, Jansen FE, Spliet WGM, Krsek P, Benova B, Zamecnik J, Crino PB, Prayer D, Czech T, Wöhrer A, Rahimi J, Höftberger R, Hainfellner JA, Feucht M, Aronica E, Novel Histopathological Patterns in Cortical Tubers of Epilepsy Surgery Patients with Tuberous Sclerosis Complex. PLOS ONE 2016;11 (6):e0157396 [PubMed]
Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H, Advances in the development of biomarkers for epilepsy. LANCET NEUROL 2016;15 (8):843-856 [PubMed]
Prabowo AS. Molecular features of long-term epilepsy-associated tumors: focus on glioneuronal tumors. S.l.: s.n.; 2016. 247p. ISBN 978-94-6299-327-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Aronica EMA; copromotor(s): Schouten-van Meeteren AYN, Iyer AM)
Ruffolo G, Iyer A, Cifelli P, Roseti C, Mühlebner A, van Scheppingen J, Scholl T, Hainfellner JA, Feucht M, Krsek P, Zamecnik J, Jansen FE, Spliet WGM, Limatola C, Aronica E, Palma E, Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions. NEUROBIOL DIS 2016;95:93-101 [PubMed]
Schipper LJ, Raaphorst J, Aronica E, Baas F, de Haan R, de Visser M, Troost D, Prevalence of brain and spinal cord inclusions, including dipeptide repeat proteins, in patients with the C9ORF72 hexanucleotide repeat expansion: a systematic neuropathological review. NEUROPATH APPL NEURO 2016;42 (6):547-560 [PubMed]
Stojanovic T, Capo I, Aronica E, Adle-Biassette H, Höger H, Sieghart W, Kovacs GG, Milenkovic I, The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development. J COMP NEUROL 2016;524 (9):1805-1824 [PubMed]
Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M, New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. CELL 2016;164 (5):1060-1072 [PubMed]
Tauziède-Espariat A, Bresson D, Polivka M, Bouazza S, Labrousse F, Aronica E, Pretet JL, Projetti F, Herman P, Salle H, Monnien F, Valmary-Degano S, Laquerrière A, Pocard M, Chaigneau L, Isambert N, Aubriot-Lorton MH, Feuvret L, George B, Froelich S, Adle-Biassette H, Prognostic and Therapeutic Markers in Chordomas: A Study of 287 Tumors. J NEUROPATH EXP NEUR 2016;75 (2):111-120 [PubMed]
van Dijk S, van der Kooi AJ, Aronica E, van Gulik TM, Busch OR, Besselink MG, Paraneoplastic Necrotizing Autoimmune Myopathy in a Patient Undergoing Laparoscopic Pancreatoduodenectomy for Distal Cholangiocarcinoma. CASE REP GASTROENTEROL 2016;10 (3):525-530 [PubMed]
van Scheppingen J, Broekaart DWM, Scholl T, Zuidberg MRJ, Anink JJ, Spliet WG, van Rijen PC, Czech T, Hainfellner JA, Feucht M, Mühlebner A, van Vliet EA, Aronica E, Dysregulation of the (immuno)proteasome pathway in malformations of cortical development. J NEUROINFLAMM 2016;13 (1):202 [PubMed]
van Scheppingen J, Iyer AM, Prabowo AS, Mühlebner A, Anink JJ, Scholl T, Feucht M, Jansen FE, Spliet WG, Krsek P, Zamecnik J, Buccoliero AM, Giordano F, Genitori L, Kotulska K, Jozwiak S, Jaworski J, Liszewska E, van Vliet EA, Aronica E, Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA-derived cell cultures. GLIA 2016;64 (6):1066-1082 [PubMed]
van Vliet EA, Otte WM, Wadman WJ, Aronica E, Kooij G, de Vries HE, Dijkhuizen RM, Gorter JA, Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms. EPILEPSIA 2016;57 (1):70-78 [PubMed]
van Vliet EA, Otte WM, Wadman WJ, Aronica E, Kooij G, de Vries HE, Dijkhuizen RM, Gorter JA, Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats I: Magnetic resonance imaging. EPILEPSIA 2016;57 (1):59-69 [PubMed]
Veersema TJ, van Eijsden P , Gosselaar PH, Hendrikse J, Zwanenburg JJM, Spliet WGM, Aronica E, Braun KPJ, Ferrier CH, 7 tesla T2*-weighted MRI as a tool to improve detection of focal cortical dysplasia 7 tesla T2*-weighted MRI as a tool to improve detection of focal cortical dysplasia. EPILEPTIC DISORD 2016;18 (3):315-323 [PubMed]
Alves MM, Fuhler GM, Queiroz KCS, Scholma J, Goorden S, Anink J, Spek CA, Hoogeveen-Westerveld M, Bruno MJ, Nellist M, Elgersma Y, Aronica E, Peppelenbosch MP, PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex. SCI REP-UK 2015;5:14534 [PubMed]
Aronica E, Michael foundation forum 2014, bonn, Germany. EPILEPSIA 2015;56 (2):319-320 [PubMed]
Aronica E, Baas F, Iyer A, ten Asbroek ALMA, Morello G, Cavallaro S, Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex. NEUROBIOL DIS 2015;74:359-376 [PubMed]
Avberšek A, Miserocchi A, McEvoy AW, Patel AV, Aronica E, Blümcke I, Jacques TS, Acheson J, Thom M, Sisodiya SM, Multiphasic presentation of Rasmussen's encephalitis. EPILEPTIC DISORD 2015;17 (3):315-320 [PubMed]
Boison D, Aronica E, Comorbidities in Neurology: Is adenosine the common link?. NEUROPHARMACOLOGY 2015;97:18-34 [PubMed]
Bruinsma CF, Schonewille M, Gao Z, Aronica EMA, Judson MC, Philpot BD, Hoebeek FE, van Woerden GM, de Zeeuw CI, Elgersma Y, Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model. J CLIN INVEST 2015;125 (11):4305-4315 [PubMed]
Cuadrado E, Vanderver A, Brown KJ, Sandza A, Takanohashi A, Jansen MH, Anink J, Herron B, Orcesi S, Olivieri I, Rice GI, Aronica E, Lebon P, Crow YJ, Hol EM, Kuijpers TW, Aicardi-Goutières syndrome harbours abundant systemic and brain-reactive autoantibodies. ANN RHEUM DIS 2015;74 (10):1931-1939 [PubMed]
de Bleecker JL, de Paepe B, Aronica E, de Visser M, Amato A, Benveniste O, de Bleecker J, de Boer O, Dimachkie M, Gherardi R, Goebel HH, Hilton-Jones D, Holton J, Lundberg IE, Mammen A, Mastaglia F, Nishino I, Rushing E, Schroder HD, Selcen D, Stenzel W, 205th ENMC International Workshop: Pathology diagnosis of idiopathic inflammatory myopathies part II 28-30 March 2014, Naarden, The Netherlands. NEUROMUSCULAR DISORD 2015;25 (3):268-272 [PubMed]
Gorter JA, van Vliet EA, Aronica E, Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis. EPILEPSY BEHAV 2015;49:13-16 [PubMed]
Harris VC, van Vugt M, Aronica E, de Bree GJ, Stijnis C, Goorhuis A, Grobusch MP, Human Extraintestinal Sarcocystosis: What We Know, and What We don't Know. CURR INFECT DIS REP 2015;17 (8):42 [PubMed]
Hira VVV, Ploegmakers KJ, Grevers F, Verbovšek U, Silvestre-Roig C, Aronica E, Tigchelaar W, Turnšek TL, Molenaar RJ, van Noorden CJF, CD133+ and Nestin+ Glioma Stem-Like Cells Reside Around CD31+ Arterioles in Niches that Express SDF-1α, CXCR4, Osteopontin and Cathepsin K. J HISTOCHEM CYTOCHEM 2015;63 (7):481-493 [PubMed]
Jaeger B, de Visser M, Aronica E, van der Kooi AJ, Respiratory failure as presenting symptom of necrotizing autoimmune myopathy with anti-melanoma differentiation-associated gene 5 antibodies. NEUROMUSCULAR DISORD 2015;25 (6):457-460 [PubMed]
Liefferinge JV, Jensen CJ, Albertini G, Bentea E, Demuyser T, Merckx E, Aronica E, Smolders I, Massie A, Altered vesicular glutamate transporter expression in human temporal lobe epilepsy with hippocampal sclerosis. NEUROSCI LETT 2015;590:184-188 [PubMed]
Malik AR, Liszewska E, Skalecka A, Urbanska M, Iyer AM, Swiech LJ, Perycz M, Parobczak K, Pietruszka P, Zarebska MM, Macias M, Kotulska K, Borkowska J, Grajkowska W, Tyburczy ME, Jozwiak S, Kwiatkowski DJ, Aronica E, Jaworski J, Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. ACTA NEUROPATHOL COM 2015;3 (1):48 [PubMed]
Mills JD, Chen J, Kim WS, Waters PD, Prabowo AS, Aronica E, Halliday GM, Janitz M, Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter. NEUROGENETICS 2015;16 (3):201-213 [PubMed]
Prabowo AS, Iyer AM, Veersema TJ, Anink JJ, Schouten-van Meeteren AYN, Spliet WGM, van Rijen PC, Ferrier CH, Thom M, Aronica E, Expression of neurodegenerative disease-related proteins and caspase-3 in glioneuronal tumours. NEUROPATH APPL NEURO 2015;41 (2):E1-E15 [PubMed]
Prabowo AS, van Scheppingen J, Iyer AM, Anink JJ, Spliet WGM, van Rijen PC, Schouten-van Meeteren AYN, Aronica E, Differential expression and clinical significance of three inflammation-related microRNAs in gangliogliomas. J NEUROINFLAMM 2015;12 (1):97 [PubMed]
Prabowo AS, van Thuijl HF, Scheinin I, Sie D, van Essen HF, Iyer AM, Spliet WGM, Ferrier CH, van Rijen PC, Veersema TJ, Thom M, Schouten-van Meeteren AYN, Reijneveld JC, Ylstra B, Wesseling P, Aronica E, Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours. NEUROPATH APPL NEURO 2015;41 (6):743-755 [PubMed]
Roseti C, van Vliet EA, Cifelli P, Ruffolo G, Baayen JC, Di Castro MA, Bertollini C, Limatola C, Aronica E, Vezzani A, Palma E, GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis. NEUROBIOL DIS 2015;82:311-320 [PubMed]
Shen HY, van Vliet EA, Bright KA, Hanthorn M, Lytle NK, Gorter J, Aronica E, Boison D, Glycine transporter 1 is a target for the treatment of epilepsy. NEUROPHARMACOLOGY 2015;99:554-565 [PubMed]
Stenzel W, Preuße C, Allenbach Y, Pehl D, Junckerstorff R, Heppner FL, Nolte K, Aronica E, Kana V, Rushing E, Schneider U, Claeys KG, Benveniste O, Weis J, Goebel HH, Nuclear actin aggregation is a hallmark of anti-synthetase syndrome-induced dysimmune myopathy. NEUROLOGY 2015;84 (13):1346-1354 [PubMed]
van Vliet EA, Aronica E, Gorter JA, Blood-brain barrier dysfunction, seizures and epilepsy. SEMIN CELL DEV BIOL 2015;38:26-34 [PubMed]
Vezzani A, Lang B, Aronica E, Immunity and Inflammation in Epilepsy. CSH PERSPECT MED 2015;6 (2):a022699 [PubMed]
Aronica E, Crino PB, Epilepsy related to developmental tumors and malformations of cortical development. NEUROTHERAPEUTICS 2014;11 (2):251-268 [PubMed]
Blumcke I, Aronica E, Urbach H, Alexopoulos A, Gonzalez-Martinez JA, A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors. ACTA NEUROPATHOL 2014;128 (1):39-54 [PubMed]
Brito MA, Pereira P, Barroso C, Aronica E, Brites D, Response to the letter to the editor by Mamdouha Ahdab-Barmada and Jon F. Watchko. PEDIATR NEUROL 2014;50 (6):e17-e18 [PubMed]
Chiavegato A, Zurolo E, Losi G, Aronica E, Carmignoto G, The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy. FRONT CELL NEUROSCI 2014;8:155 [PubMed]
Coumou AD, Merks JHM, Aronica E, Mourits MP, Saeed P, Ectopic brain tissue in the orbit: 5-year follow-up. ORBIT 2014;33 (1):78-80 [PubMed]
Dalen Meurs-van der Schoor C, van Weissenbruch M, van Kempen M, Bugiani M, Aronica E, Ronner H, Vermeulen RJ, Severe Neonatal Epileptic Encephalopathy and KCNQ2 Mutation: Neuropathological Substrate?. FRONT PEDIATR 2014;2:136 [PubMed]
Dell'Albani P, Rodolico M, Pellitteri R, Tricarichi E, Torrisi SA, D'Antoni S, Zappia M, Albanese V, Caltabiano R, Platania N, Aronica E, Catania MV, Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation. NEURO-ONCOLOGY 2014;16 (2):204-216 [PubMed]
Eggens VR, Barth PG, Niermeijer JMF, Berg JN, Darin N, Dixit A, Fluss J, Foulds N, Fowler D, Hortobágyi T, Jacques T, King MD, Makrythanasis P, Máté A, Nicoll JAR, O'Rourke D, Price S, Williams AN, Wilson L, Suri M, Sztriha L, Dijns-de Wissel MB, van Meegen MT, van Ruissen F, Aronica E, Troost D, Majoie CB, Marquering HA, Poll-Thé BT, Baas F, EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations. ORPHANET J RARE DIS 2014;9 (1):23 [PubMed]
Esposito DH, Stich A, Epelboin L, Malvy D, Han PV, Bottieau E, da Silva A, Zanger P, Slesak G, van Genderen PJJ, Rosenthal BM, Cramer JP, Visser LG, Muñoz J, Drew CP, Goldsmith CS, Steiner F, Wagner N, Grobusch MP, Plier DA, Tappe D, Sotir MJ, Brown C, Brunette GW, Fayer R, von Sonnenburg F, Neumayr A, Kozarsky PE [Contributors: van den Enden E, van Esbroeck M, Ghesquiere W, Nguyen D, Receveur MC, Peyron F, Parola P, Savini H, Caumes E, Perignon A, Develoux M, Rapp C, Keller CA, Haditsch M, Güthoff W, Liebold I, Schäfer J, Gobbi F, Kortmann W, van Twillert G, Goorhuis A, van Vugt M, Stijnis K, Aronica E, van Lieshout L, Roestenberg M, van Wout J, Barkham T, Lim PL, Hatz C, Brugger SD, Furrer H, Chappuis F, Michel Y, Choochumporn S, Narkwiboonwong T, Dryden MS, Benedict T, Handali S, Wilkins PP, Shieh WJ, Zaki S, Kogelman L, Hatch S]] , Acute muscular sarcocystosis: an international investigation among ill travelers returning from Tioman Island, Malaysia, 2011-2012. CLIN INFECT DIS 2014;59 (10):1401-1410 [PubMed]
Ferreira V, Twisk J, Kwikkers K, Aronica E, Brisson D, Methot J, Petry H, Gaudet D, Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy. HUM GENE THER 2014;25 (3):180-188 [PubMed]
Gorter JA, Iyer A, White I, Colzi A, van Vliet EA, Sisodiya S, Aronica E, Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy. NEUROBIOL DIS 2014;62:508-520 [PubMed]
Iyer AM, van Scheppingen J, Milenkovic I, Anink JJ, Adle-Biassette H, Kovacs GG, Aronica E, mTOR Hyperactivation in down syndrome hippocampus appears early during development. J NEUROPATH EXP NEUR 2014;73 (7):671-683 [PubMed]
Iyer AM, van Scheppingen J, Milenkovic I, Anink JJ, Lim D, Genazzani AA, Adle-Biassette H, Kovacs GG, Aronica E, Metabotropic glutamate receptor 5 in Down's syndrome hippocampus during development: increased expression in astrocytes. CURR ALZHEIMER RES 2014;11 (7):694-705 [PubMed]
Iyer A, Prabowo A, Anink J, Spliet WGM, van Rijen PC, Aronica E, Cell injury and premature neurodegeneration in focal malformations of cortical development. BRAIN PATHOL 2014;24 (1):1-17 [PubMed]
Jovanov Milošević N, Judaš M, Aronica E, Kostovic I, Neural ECM in laminar organization and connectivity development in healthy and diseased human brain. PROG BRAIN RES 2014;214:159-178 [PubMed]
Kaalund SS, Venø MT, Bak M, Møller RS, Laursen H, Madsen F, Broholm H, Quistorff B, Uldall P, Tommerup N, Kauppinen S, Sabers A, Fluiter K, Møller LB, Nossent AY, Silahtaroglu A, Kjems J, Aronica E, Tümer Z, Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance. EPILEPSIA 2014;55 (12):2017-2027 [PubMed]
Kanski R, Sneeboer MAM, van Bodegraven EJ, Sluijs JA, Kropff W, Vermunt MW, Creyghton MP, de Filippis L, Vescovi A, Aronica E, van Tijn P, van Strien ME, Hol EM, Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network. J CELL SCI 2014;127 (Part 20):4368-4380 [PubMed]
Korshunov A, Sturm D, Ryzhova M, Hovestadt V, Gessi M, Jones DTW, Remke M, Northcott P, Perry A, Picard D, Rosenblum M, Antonelli M, Aronica E, Schüller U, Hasselblatt M, Woehrer A, Zheludkova O, Kumirova E, Puget S, Taylor MD, Giangaspero F, Peter Collins V, von Deimling A, Lichter P, Huang A, Pietsch T, Pfister SM, Kool M, Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. ACTA NEUROPATHOL 2014;128 (2):279-289 [PubMed]
Kovacs GG, Adle-Biassette H, Milenkovic I, Cipriani S, van Scheppingen J, Aronica E, Linking pathways in the developing and aging brain with neurodegeneration. NEUROSCIENCE 2014;269:152-172 [PubMed]
Lewerenz J, Baxter P, Kassubek R, Albrecht P, van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P, Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy. ANTIOXID REDOX SIGN 2014;20 (18):2907-2922 [PubMed]
Marlatt MW, Bauer J, Aronica E, van Haastert ES, Hoozemans JJM, Joels M, Lucassen PJ, Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. NEURAL PLAST 2014;2014:693851 [PubMed]
Milesi G, Garbelli R, Zucca I, Aronica E, Spreafico R, Frassoni C, Assessment of human hippocampal developmental neuroanatomy by means of ex-vivo 7 T magnetic resonance imaging. INT J DEV NEUROSCI 2014;34:33-41 [PubMed]
Prabowo AS, Iyer AM, Veersema TJ, Anink JJ, Schouten-van Meeteren AYN, Spliet WGM, van Rijen PC, Ferrier CH, Capper D, Thom M, Aronica E, BRAF V600E Mutation Is Associated with mTOR Signaling Activation in Glioneuronal Tumors. BRAIN PATHOL 2014;24 (1):52-66 [PubMed]
Radke J, Pehl D, Aronica E, Schonenberg-Meinema D, Schneider U, Heppner FL, de Visser M, Goebel HH, Stenzel W, The lymphoid follicle variant of dermatomyositis. NEUROL NEUROIMMUNOL NEUROINFLAMM 2014;1 (2):e19 [PubMed]
Ranno E, D'Antoni S, Spatuzza M, Berretta A, Laureanti F, Bonaccorso CM, Pellitteri R, Longone P, Spalloni A, Iyer AM, Aronica E, Catania MV, Endothelin-1 is over-expressed in amyotrophic lateral sclerosis and induces motor neuron cell death. NEUROBIOL DIS 2014;65:160-171 [PubMed]
Rizzo S, Basso C, Troost D, Aronica E, Frigo AC, Driessen AHG , Thiene G, Wilde AAM, van der Wal AC, T-Cell-Mediated Inflammatory Activity in the Stellate Ganglia of Patients With Ion-Channel Disease and Severe Ventricular Arrhythmias. CIRC-ARRHYTHMIA ELEC 2014;7 (2):224-229 [PubMed]
Schiering IAM, de Haan TR, Niermeijer JMF, Koelman JH, Majoie CBLM, Reneman L, Aronica E, Correlation Between Clinical and Histologic Findings in the Human Neonatal Hippocampus After Perinatal Asphyxia. J NEUROPATH EXP NEUR 2014;73 (4):324-334 [PubMed]
ten Donkelaar HJ, Lammens M, Aronica E, van Bokhoven H, Kamphuis-van Ulzen K, Hori A. Development and developmental disorders of the cerebral cortex in: ten Donkelaar HJ, Lammens M, Hori A, editors. Clinical neuroembryology : Development and developmental disorders of the human central nervous system (2nd ed). Berlin; Heidelberg: Springer; 2014., p. 523-642
Tsai V, Parker WE, Orlova KA, Baybis M, Chi AWS, Berg BD, Birnbaum JF, Estevez J, Okochi K, Sarnat HB, Flores-Sarnat L, Aronica E, Crino PB, Fetal Brain mTOR Signaling Activation in Tuberous Sclerosis Complex. CEREB CORTEX 2014;24 (2):315-327 [PubMed]
van Strien ME, Sluijs JA, Reynolds BA, Steindler DA, Aronica E, Hol EM, Isolation of neural progenitor cells from the human adult subventricular zone based on expression of the cell surface marker CD271. STEM CELL TRANSL MED 2014;3 (4):470-480 [PubMed]
van Thuijl HF, Scheinin I, Sie D, Alentorn A, van Essen HF, Cordes M, Fleischeuer R, Gijtenbeek AM, Beute G, van den Brink WA, Meijer GA, Havenith M, Idbaih A, Hoang-Xuan K, Mokhtari K, Verhaak R, van der Valk P, van de Wiel MA, Heimans JJ, Aronica E, Reijneveld JC, Wesseling P, Ylstra B, Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas. GENOME BIOL 2014;15 (9):471 [PubMed]
van Vliet EA, Aronica E, Gorter JA, Role of blood-brain barrier in temporal lobe epilepsy and pharmacoresistance. NEUROSCIENCE 2014;277:455-473 [PubMed]
van Vuurden DG, Aronica E, Hulleman E, Wedekind LE, Biesmans D, Malekzadeh A, Bugiani M, Geerts D, Noske DP, Vandertop WP, Kaspers GJL, Cloos J, Würdinger T, van der Stoop PPM, Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration. NEURO-ONCOLOGY 2014;16 (7):946-959 [PubMed]
Zellinger C, Salvamoser JD, Soerensen J, van Vliet EA, Aronica E, Gorter J, Potschka H, Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model. EPILEPSY RES 2014;108 (4):634-643 [PubMed]
Aronica E, Sandau US, Iyer A, Boison D, Glial adenosine kinase--a neuropathological marker of the epileptic brain. NEUROCHEM INT 2013;63 (7):688-695 [PubMed]
Balosso S, Ravizza T, Aronica E, Vezzani A, The dual role of TNF-α and its receptors in seizures. EXP NEUROL 2013;247:267-271 [PubMed]
Bink DI, Ritz K, Aronica E, van der Weerd L, Daemen MJAP, Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition. J CEREBR BLOOD F MET 2013;33 (11):1666-1684 [PubMed]
Blümcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A, Bernasconi N, Bien CG, Cendes F, Coras R, Cross JH, Jacques TS, Kahane P, Mathern GW, Miyata H, Moshé SL, Oz B, Ozkara C, Perucca E, Sisodiya S, Wiebe S, Spreafico R, International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods. EPILEPSIA 2013;54 (7):1315-1329 [PubMed]
Brito MA, Pereira P, Barroso C, Aronica E, Brites D, New Autopsy Findings in Different Brain Regions of a Preterm Neonate With Kernicterus: Neurovascular Alterations and Up-regulation of Efflux Transporters. PEDIATR NEUROL 2013;49 (6):431-438 [PubMed]
Cuadrado E, Jansen MH, Anink J, de Filippis L, Vescovi AL, Watts C, Aronica E, Hol EM, Kuijpers TW, Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome. BRAIN 2013;136 (1):245-258 [PubMed]
de Groot M. Epilepsy in brain tumor patients: towards improved and personalized treatment. s.l.: s.n.; 2013. -p. Proefschrift VU, VUmc. (Promotor(s): Heimans JJ; copromotor(s): Reijneveld JC, Aronica E)
Douw L, de Groot M, van Dellen E, Aronica E, Heimans JJ, Klein M, Stam CJ, Reijneveld JC, Hillebrand A, Local MEG networks: the missing link between protein expression and epilepsy in glioma patients?. NEUROIMAGE 2013;75:195-203 [PubMed]
Groen EJN, Fumoto K, Blokhuis AM, Engelen-Lee J, Zhou Y, van den Heuvel DMA, Koppers M, van Diggelen F, van Heest J, Demmers JAA, Kirby J, Shaw PJ, Aronica E, Spliet WGM, Veldink JH, van den Berg LH, Pasterkamp RJ, ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN. HUM MOL GENET 2013;22 (18):3690-3704 [PubMed]
Holtman L, van Vliet EA, Aronica E, Wouters D, Wadman WJ, Gorter JA, Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. EPILEPSIA 2013;54 (4):589-595 [PubMed]
Iori V, Maroso M, Rizzi M, Iyer AM, Vertemara R, Carli M, Agresti A, Antonelli A, Bianchi ME, Aronica E, Ravizza T, Vezzani A, Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures. NEUROBIOL DIS 2013;58:102-114 [PubMed]
Iyer A, van Scheppingen J, Anink J, Milenkovic I, Kovács GG, Aronica E, Developmental patterns of DR6 in normal human hippocampus and in Down syndrome. J NEURODEV DISORD 2013;5 (1):10 [PubMed]
Lim D, Iyer A, Ronco V, Grolla AA, Canonico PL, Aronica E, Genazzani AA, Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB. GLIA 2013;61 (7):1134-1145 [PubMed]
Mizee MR, Wooldrik D, Lakeman KAM, van het Hof B, Drexhage JAR, Geerts D, Bugiani M, Aronica E, Mebius RE, Prat A, de Vries HE, Reijerkerk A, Retinoic acid induces blood-brain barrier development. J NEUROSCI 2013;33 (4):1660-1671 [PubMed]
Prabowo AS, Anink JJ, Lammens M, Nellist M, van den Ouweland AMW, Adle-Biassette H, Sarnat HB, Flores-Sarnat L, Crino PB, Aronica E, Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation. BRAIN PATHOL 2013;23 (1):45-59 [PubMed]
Prabowo AS, Iyer AM, Anink JJ, Spliet WGM, van Rijen PC, Aronica E, Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions. J NEUROINFLAMM 2013;10:12 [PubMed]
Roseti C, Fucile S, Lauro C, Martinello K, Bertollini C, Esposito V, Mascia A, Catalano M, Aronica E, Limatola C, Palma E, Fractalkine/CX3CL1 modulates GABAA currents in human temporal lobe epilepsy. EPILEPSIA 2013;54 (10):1834-1844 [PubMed]
Vezzani A, Aronica E, Mazarati A, Pittman QJ, Epilepsy and brain inflammation. EXP NEUROL 2013;244:11-21 [PubMed]
Voermans NC, Jungbluth H, Aronica E, Monnier N, Lunardi J, Swash M, de Visser M, Congenital myopathy with focal loss of cross-striations revisited. NEUROMUSCULAR DISORD 2013;23 (2):160-164 [PubMed]
Wang Q, van Heerikhuize J, Aronica E, Kawata M, Seress L, Joels M, Swaab DF, Lucassen PJ, Glucocorticoid receptor protein expression in human hippocampus; stability with age. NEUROBIOL AGING 2013;34 (6):1662-1673 [PubMed]
Weterman MAJ, Barth PG, van Spaendonck-Zwarts KY, Aronica E, Poll-The BT, Brouwer OF, van Tintelen JP, Qahar Z, Bradley EJ, de Wissel M, Salviati L, Angelini C, van den Heuvel L, Thomasse YEM, Backx AP, Nürnberg G, Nürnberg P, Baas F, Recessive MYL2 mutations cause infantile type I muscle fibre disease and cardiomyopathy. BRAIN 2013;136 (1):282-293 [PubMed]
Zurolo E. Inflammation and epilepsy: the contribution of astrocytes. s.l.: s.n.; 2013. 294p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Troost D, Aronica EMA; copromotor(s): )
Aronica E, Becker AJ, Spreafico R, Malformations of Cortical Development. BRAIN PATHOL 2012;22 (3):380-401 [PubMed]
Aronica E, Niehusmann P. Gangliogliomas: Molecular Pathogenesis and Epileptogenesis in: Hayat MA, editors. Tumors of the Central Nervous System. Vol 5: Astrocytomas, Hemangioblastomas, and Gangliogliomas. Berlin: Springer; 2012., p. 253-265
Aronica E, Ravizza T, Zurolo E, Vezzani A, Astrocyte immune responses in epilepsy. GLIA 2012;60 (8):1258-1268 [PubMed]
Aronica E, Sisodiya SM, Gorter JA, Cerebral expression of drug transporters in epilepsy. ADV DRUG DELIVER REV 2012;64 (10):919-929 [PubMed]
Brito MA, Zurolo E, Pereira P, Barroso C, Aronica E, Brites D, Cerebellar Axon/Myelin Loss, Angiogenic Sprouting, and Neuronal Increase of Vascular Endothelial Growth Factor in a Preterm Infant with Kernicterus. J CHILD NEUROL 2012;27 (5):615-624 [PubMed]
Chen J, Tsai V, Parker WE, Aronica E, Baybis M, Crino PB, Detection of Human Papillomavirus in Human Focal Cortical Dysplasia Type IIB. ANN NEUROL 2012;72 (6):881-892 [PubMed]
Coras R, de Boer OJ, Armstrong D, Becker A, Jacques TS, Miyata H, Thom M, Vinters HV, Spreafico R, Oz B, Marucci G, Pimentel J, Mühlebner A, Zamecnik J, Buccoliero AM, Rogerio F, Streichenberger N, Arai N, Bugiani M, Vogelgesang S, Macaulay R, Salon C, Hans V, Polivka M, Giangaspero F, Fauziah D, Kim JH, Liu L, Dandan W, Gao J, Lindeboom B, Blümcke I, Aronica E, Good interobserver and intraobserver agreement in the evaluation of the new ILAE classification of focal cortical dysplasias. EPILEPSIA 2012;53 (8):1341-1348 [PubMed]
de Groot M, Iyer A, Zurolo E, Anink J, Heimans JJ, Boison D, Reijneveld JC, Aronica E, Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy. EPILEPSIA 2012;53 (1):58-66 [PubMed]
de Groot M, Reijneveld JC, Aronica E, Heimans JJ, Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment. BRAIN 2012;135 (4):1002-1016 [PubMed]
Iyer A, Zurolo E, Prabowo A, Fluiter K, Spliet WGM, van Rijen PC, Gorter JA, Aronica E, MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response. PLOS ONE 2012;7 (9):e44789 [PubMed]
Korshunov A, Ryzhova M, Jones DTW, Northcott PA, van Sluis P, Volckmann R, Koster J, Versteeg R, Cowdrey C, Perry A, Picard D, Rosenblum M, Giangaspero F, Aronica E, Schüller U, Hasselblatt M, Collins VP, von Deimling A, Lichter P, Huang A, Pfister SM, Kool M, LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). ACTA NEUROPATHOL 2012;124 (6):875-881 [PubMed]
Marcotte L, Aronica E, Baybis M, Crino PB, Cytoarchitectural alterations are widespread in cerebral cortex in tuberous sclerosis complex. ACTA NEUROPATHOL 2012;123 (5):685-693 [PubMed]
Maroso M. The role of IL-1 receptor/toll-like receptor signaling in seizures. s.l.: s.n.; 2012. 104p. ISBN 9789090267142 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Troost D; copromotor(s): Aronica EMA, Vezzani A)
Martorana F, Brambilla L, Valori CF, Bergamaschi C, Roncoroni C, Aronica E, Volterra A, Bezzi P, Rossi D, The BH4 domain of Bcl-X-L rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals. HUM MOL GENET 2012;21 (4):826-840 [PubMed]
Meijer-Jorna LB, Aronica E, van der Loos CM, Troost D, van der Wal AC, Congenital vascular malformations - cerebral lesions differ from extracranial lesions by their immune expression of the glucose transporter protein GLUT1. CLIN NEUROPATHOL 2012;31 (3):135-141 [PubMed]
Rohof WO, Aronica E, Beaumont H, Troost D, Boeckxstaens GE, Localization of mGluR5, GABAB, GABAA, and cannabinoid receptors on the vago-vagal reflex pathway responsible for transient lower esophageal sphincter relaxation in humans: an immunohistochemical study. NEUROGASTROENT MOTIL 2012;24 (4):383-e173 [PubMed]
Sharifi S, Aronica E, Koelman JHTM, Tijssen MAJ, van Rootselaar AF, Familial cortical myoclonic tremor with epilepsy and cerebellar changes: description of a new pathology case and review of the literature. TREMOR OTHER HYPERKINET MOV (N Y) 2012;2 (-):82 [PubMed]
Smits A, Jin Z, Elsir T, Pedder H, Nistér M, Alafuzoff I, Dimberg A, Edqvist PH, Pontén F, Aronica E, Birnir B, GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome. PLOS ONE 2012;7 (5):e37041 [PubMed]
Smits M, van Rijn S, Hulleman E, Biesmans D, van Vuurden DG, Kool M, Haberler C, Aronica E, Vandertop WP, Noske DP, Würdinger T, EZH2-Regulated DAB2IP Is a Medulloblastoma Tumor Suppressor and a Positive Marker for Survival. CLIN CANCER RES 2012;18 (15):4048-4058 [PubMed]
Stenzel W, Goebel HH, Aronica E, Review: Immune-mediated necrotizing myopathies - a heterogeneous group of diseases with specific myopathological features. NEUROPATH APPL NEURO 2012;38 (7):632-646 [PubMed]
Thom M, Blümcke I, Aronica E, Long-Term Epilepsy-Associated Tumors. BRAIN PATHOL 2012;22 (3):350-379 [PubMed]
van Vliet EA, Forte G, Holtman L, den Burger JCG, Sinjewel A, de Vries HE, Aronica E, Gorter JA, Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. EPILEPSIA 2012;53 (7):1254-1263 [PubMed]
Westerman BA, Blom M, Tanger E, van der Valk M, Song JY, van Santen M, Gadiot J, Cornelissen-Steijger P, Zevenhoven J, Prosser HM, Uren A, Aronica E, van Lohuizen M, GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors. PLOS ONE 2012;7 (5):e35943 [PubMed]
Zurolo E, de Groot M, Iyer A, Anink J, van Vliet EA, Heimans JJ, Reijneveld JC, Gorter JA, Aronica E, Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 beta. J NEUROINFLAMM 2012;9 (1):280 [PubMed]
Aronica E, Iyer A, Zurolo E, Gorter JA, Ontogenetic modifications of neuronal excitability during brain maturation: developmental changes of neurotransmitter receptors. EPILEPSIA 2011;52 (Suppl. 8):3-5 [PubMed]
Aronica E, Zurolo E, Iyer A, de Groot M, Anink J, Carbonell C, van Vliet EA, Baayen JC, Boison D, Gorter JA, Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. EPILEPSIA 2011;52 (9):1645-1655 [PubMed]
Battaglia G, Cannella M, Riozzi B, Orobello S, Maat-Schieman ML, Aronica E, Busceti CL, Ciarmiello A, Alberti S, Amico E, Sassone J, Sipione S, Bruno V, Frati L, Nicoletti F, Squitieri F, Early defect of transforming growth factor β(1) formation in Huntington's disease. J CELL MOL MED 2011;15 (3):555-571 [PubMed]
Blümcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross JH, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Ozkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vezzani A, Spreafico R, The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. EPILEPSIA 2011;52 (1):158-174 [PubMed]
Casula M, Iyer AM, Spliet WGM, Anink JJ, Steentjes K, Sta M, Troost D, Aronica E, TOLL-LIKE RECEPTOR SIGNALING IN AMYOTROPHIC LATERAL SCLEROSIS SPINAL CORD TISSUE. NEUROSCIENCE 2011;179:233-243 [PubMed]
Casula M, Steentjes K, Aronica E, van Geel BM, Troost D, Concomitant CNS pathology in a patient with amyotropic lateral sclerosis following poliomyelitis in childhood. CLIN NEUROPATHOL 2011;30 (3):111-117 [PubMed]
Conti L, Palma E, Roseti C, Lauro C, Cipriani R, de Groot M, Aronica E, Limatola C, Anomalous levels of Cl(-) transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex. EPILEPSIA 2011;52 (9):1635-1644 [PubMed]
de Groot M, Aronica E, Heimans JJ, Reijneveld JC, Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. NEUROLOGY 2011;77 (6):532-539 [PubMed]
Holtman L, van Vliet EA, Baas F, Aronica E, Gorter JA, Complement protein 6 deficiency in PVG/c rats does not lead to neuroprotection against seizure induced cell death. NEUROSCIENCE 2011;188:109-116 [PubMed]
Kooi EJ, Prins M, Bajic N, Beliën JAM, Gerritsen WH, van Horssen J, Aronica E, van Dam AM, Hoozemans JJM, Francis PT, van der Valk P, Geurts JJG, Cholinergic imbalance in the multiple sclerosis hippocampus. ACTA NEUROPATHOL 2011;122 (3):313-322 [PubMed]
Parker WE, Orlova KA, Heuer GG, Baybis M, Aronica E, Frost M, Wong M, Crino PB, Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex. AM J PATHOL 2011;178 (1):296-305 [PubMed]
Ritz K, van Schaik BDC, Jakobs ME, Aronica E, Tijssen MA, van Kampen AHC, Baas F, Looking ultra deep: short identical sequences and transcriptional slippage. GENOMICS 2011;98 (2):90-95 [PubMed]
Ritz K, van Schaik BD, Jakobs ME, van Kampen AH, Aronica E, Tijssen MA, Baas F, SGCE isoform characterization and expression in human brain: implications for myoclonus-dystonia pathogenesis?. EUR J HUM GENET 2011;19 (4):438-444 [PubMed]
Sta M, Sylva-Steenland RMR, Casula M, de Jong JMBV, Troost D, Aronica E, Baas F, Innate and adaptive immunity in amyotrophic lateral sclerosis: Evidence of complement activation. NEUROBIOL DIS 2011;42 (3):211-220 [PubMed]
van Munster BC, Aronica E, Zwinderman AH, Eikelenboom P, Cunningham C, de Rooij SEJA, Neuroinflammation in delirium: a postmortem case-control study. REJUV RES 2011;14 (6):615-622 [PubMed]
van Vliet EA, Holtman L, Aronica E, Schmitz LJM, Wadman WJ, Gorter JA, Atorvastatin treatment during epileptogenesis in a rat model for temporal lobe epilepsy. EPILEPSIA 2011;52 (7):1319-1330 [PubMed]
Zurolo E, Iyer A, Maroso M, Carbonell C, Anink JJ, Ravizza T, Fluiter K, Spliet WGM, van Rijen PC, Vezzani A, Aronica E, Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. BRAIN 2011;134 (Part 4):1015-1032 [PubMed]
Aronica E, Fluiter K, Iyer A, Zurolo E, Vreijling J, van Vliet EA, Baayen JC, Gorter JA, Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. EUR J NEUROSCI 2010;31 (6):1100-1107 [PubMed]
Boer K, Crino PB, Gorter JA, Nellist M, Jansen FE, Spliet WGM, van Rijen PC, Wittink FRA, Breit TM, Troost D, Wadman WJ, Aronica E, Gene Expression Analysis of Tuberous Sclerosis Complex Cortical Tubers Reveals Increased Expression of Adhesion and Inflammatory Factors. BRAIN PATHOL 2010;20 (4):704-719 [PubMed]
Boer K, Encha-Razavi F, Sinico M, Aronica E, Differential distribution of group I metabotropic glutamate receptors in developing human cortex. BRAIN RES 2010;1324:24-33 [PubMed]
Boer K, Middeldorp J, Spliet WGM, Razavi F, van Rijen PC, Baayen JC, Hol EM, Aronica E, Immunohistochemical characterization of the out-of frame splice variants GFAP Delta164/Deltaexon 6 in focal lesions associated with chronic epilepsy. EPILEPSY RES 2010;90 (1-2):99-109 [PubMed]
Boer K, Spliet WGM, van Rijen PC, Jansen FE, Aronica E, Expression patterns of AMOG in developing human cortex and malformations of cortical development. EPILEPSY RES 2010;91 (1):84-93 [PubMed]
Boer K, Troost D, Timmermans W, van Rijen PC, Spliet WGM, Aronica E, Pi3K-mTOR Signaling and AMOG Expression in Epilepsy-associated Glioneuronal Tumors. BRAIN PATHOL 2010;20 (1):234-244 [PubMed]
Bolling MC, Pas HH, de Visser M, Aronica E, Pfendner EG, van den Berg MP, Diercks GFH, Suurmeijer AJH, Jonkman MF, PLEC1 Mutations Underlie Adult-Onset Dilated Cardiomyopathy in Epidermolysis Bullosa Simplex with Muscular Dystrophy. J INVEST DERMATOL 2010;130 (4):1178-1181 [PubMed]
Crino PB, Aronica E, Baltuch G, Nathanson KL, Biallelic TSC gene inactivation in tuberous sclerosis complex. NEUROLOGY 2010;74 (21):1716-1723 [PubMed]
de Groot M, Toering ST, Boer K, Spliet WGM, Heimans JJ, Aronica E, Reijneveld JC, Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortex. NEURO-ONCOLOGY 2010;12 (3):265-273 [PubMed]
Gorter JA, Zurolo E, Iyer A, Fluiter K, van Vliet EA, Baayen JC, Aronica E, Induction of sodium channel Na(x) (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy. EPILEPSIA 2010;51 (9):1791-1800 [PubMed]
Hadjivassiliou G, Martinian L, Squier W, Blumcke I, Aronica E, Sisodiya SM, Thom M, The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy. ACTA NEUROPATHOL 2010;120 (4):517-528 [PubMed]
Holtman L, van Vliet EA, Edelbroek PM, Aronica E, Gorter JA, Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. EPILEPSY RES 2010;91 (1):49-56 [PubMed]
Iyer AM, Zurolo E, Boer K, Baayen JC, Giangaspero F, Arcella A, Di Gennaro GC, Esposito V, Spliet WGM, van Rijen PC, Troost D, Gorter JA, Aronica E, Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies. NEUROSCIENCE 2010;167 (3):929-945 [PubMed]
Iyer A, Zurolo E, Spliet WGM, van Rijen PC, Baayen JC, Gorter JA, Aronica E, Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias. EPILEPSIA 2010;51 (9):1763-1773 [PubMed]
Lucassen PJ, Stumpel MW, Wang Q, Aronica E, Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. NEUROPHARMACOLOGY 2010;58 (6):940-949 [PubMed]
Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, Rossetti C, Molteni M, Casalgrandi M, Manfredi AA, Bianchi ME, Vezzani A, Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. NAT MED 2010;16 (4):413-419 [PubMed]
Middeldorp J, Boer K, Sluijs JA, de Filippis L, Encha-Razavi F, Vescovi AL, Swaab DF, Aronica E, Hol EM, GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex. DEVELOPMENT 2010;137 (2):313-321 [PubMed]
Orlova KA, Tsai V, Baybis M, Heuer GG, Sisodiya S, Thom M, Strauss K, Aronica E, Storm PB, Crino PB, Early Progenitor Cell Marker Expression Distinguishes Type II From Type I Focal Cortical Dysplasias. J NEUROPATH EXP NEUR 2010;69 (8):850-863 [PubMed]
van Vliet EA, Zibell G, Pekcec A, Schlichtiger J, Edelbroek PM, Holtman L, Aronica E, Gorter JA, Potschka H, COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. NEUROPHARMACOLOGY 2010;58 (2):404-412 [PubMed]
Vezzani A, Auvin S, Ravizza T, Aronica E, Glia-neuron interactions in epilepsy: Inflammatory mediators. EPILEPSIA 2010;51 (Suppl. 5):55
Zurolo E, Iyer AM, Spliet WGM, van Rijen PC, Troost D, Gorter JA, Aronica E, CB1 AND CB2 CANNABINOID RECEPTOR EXPRESSION DURING DEVELOPMENT AND IN EPILEPTOGENIC DEVELOPMENTAL PATHOLOGIES. NEUROSCIENCE 2010;170 (1):28-41 [PubMed]
Aronica E, Boer K, Doorn KJ, Zurolo E, Spliet WGM, van Rijen PC, Baayen JC, Gorter JA, Jeromin A, Expression and localization of voltage dependent potassium channel Kv4.2 in epilepsy associated focal lesions. NEUROBIOL DIS 2009;36 (1):81-95 [PubMed]
Baybis M, Aronica E, Nathanson KL, Crino PB, Deletion of 15q11.2-15q13.1 in isolated human hemimegalencephaly. ACTA NEUROPATHOL 2009;118 (6):821-823 [PubMed]
Blümcke I, Vinters HV, Armstrong D, Aronica E, Thom M, Spreafico R, Malformations of cortical development and epilepsies: neuropathological findings with emphasis on focal cortical dysplasia. EPILEPTIC DISORD 2009;11 (3):181-193 [PubMed]
Boer K. Molecular alterations in epilepsy-associated malformations of cortical development. s.l: s.n.; 2009. 256p. ISBN 9789090245881 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Troost D; copromotor(s): Aronica E)
Boer K, Lucassen PJ, Spliet WGM, Vreugdenhil E, van Rijen PC, Troost D, Jansen FE, Aronica E, Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers. EPILEPSIA 2009;50 (12):2629-2637 [PubMed]
Holtman L, van Vliet EA, van Schaik R, Queiroz CM, Aronica E, Gorter JA, Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy. EPILEPSY RES 2009;84 (1):56-66 [PubMed]
Martinian L, Boer K, Middeldorp J, Hol EM, Sisodiya SM, Squier W, Aronica E, Thom M, Expression patterns of glial fibrillary acidic protein (GFAP)-delta in epilepsy-associated lesional pathologies. NEUROPATH APPL NEURO 2009;35 (4):394-405 [PubMed]
Middeldorp J, van den Berge SA, Aronica E, Speijer D, Hol EM, Specific human astrocyte subtype revealed by affinity purified GFAP antibody; unpurified serum cross-reacts with neurofilament-L in Alzheimer. PLOS ONE 2009;4 (11):e7663 [PubMed]
Qu M, Aronica E, Boer K, Fällmar D, Kumlien E, Nistér M, Wester K, Pontén F, Smits A, DLG3/SAP102 protein expression in malformations of cortical development: a study of human epileptic cortex by tissue microarray. EPILEPSY RES 2009;84 (1):33-41 [PubMed]
Roseti C, Palma E, Martinello K, Fucile S, Morace R, Esposito V, Cantore G, Arcella A, Giangaspero F, Aronica E, Mascia A, Di Gennaro G, Quarato PP, Manfredi M, Cristalli G, Lambertucci C, Marucci G, Volpini R, Limatola C, Eusebi F, Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABA(A) receptors microtransplanted to Xenopus oocytes. P NATL ACAD SCI USA 2009;106 (37):15927-15931 [PubMed]
Srikandarajah N, Martinian L, Sisodiya SM, Squier W, Blumcke I, Aronica E, Thom M, Doublecortin expression in focal cortical dysplasia in epilepsy. EPILEPSIA 2009;50 (12):2619-2628 [PubMed]
Toering ST, Boer K, de Groot M, Troost D, Heimans JJ, Spliet WGM, van Rijen PC, Jansen FE, Gorter JA, Reijneveld JC, Aronica E, Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers. EPILEPSIA 2009;50 (6):1409-1418 [PubMed]
van Thiel PPAM, de Bie RMA, Eftimov F, Tepaske R, Zaaijer HL, van Doornum GJJ, Schutten M, Osterhaus ADME, Majoie CBLM, Aronica E, Fehlner-Gardiner C, Wandeler AI, Kager PA, Fatal human rabies due to Duvenhage virus from a bat in Kenya: failure of treatment with coma-induction, ketamine, and antiviral drugs. PLOS NEGLECT TROP D 2009;3 (7):e428 [PubMed]
van Vliet EA, Aronica E, Redeker S, Boer K, Gorter JA, Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy. EPILEPSIA 2009;50 (3):422-433 [PubMed]
van Vuurden DG, Yazdani M, Bosma I, Broekhuizen AJF, Postma TJ, Heimans JJ, van der Valk P, Aronica E, Tannous BA, Würdinger T, Kaspers GJL, Cloos J, Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment. PLOS ONE 2009;4 (6):e5953 [PubMed]
Aronica E, Boer K, Becker A, Redeker S, Spliet WGM, van Rijen PC, Wittink F, Breit T, Wadman WJ, Lopes da Silva FH, Troost D, Gorter JA, Gene expression profile analysis of epilepsy-associated gangliogliomas. NEUROSCIENCE 2008;151 (1):272-292 [PubMed]
Barth PG, Ryan MM, Webster RI, Aronica E, Kan A, Ramkema M, Jardine P, Poll-The BT, Rhabdomyolysis in pontocerebellar hypoplasia type 2 (PCH-2). NEUROMUSCULAR DISORD 2008;18 (1):52-58 [PubMed]
Boer K, Jansen F, Nellist M, Redeker S, van den Ouweland AMW, Spliet WGM, van Nieuwenhuizen O, Troost D, Crino PB, Aronica E, Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex. EPILEPSY RES 2008;78 (1):7-21 [PubMed]
Boer K, Troost D, Jansen F, Nellist M, van den Ouweland AMW, Geurts JJG, Spliet WGM, Crino P, Aronica E, Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex. NEUROPATHOLOGY 2008;28 (6):577-590 [PubMed]
Boer K, Troost D, Spliet WGM, van Rijen PC, Gorter JA, Aronica E, Cellular distribution of vascular endothelial growth factor A (VEGFA) and B (VEGFB) and VEGF receptors 1 and 2 in focal cortical dysplasia type IIB. ACTA NEUROPATHOL 2008;115 (6):683-696 [PubMed]
Boer K, Troost D, Timmermans W, Gorter JA, Spliet WGM, Nellist M, Jansen F, Aronica E, Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex. NEUROSCIENCE 2008;156 (1):203-215 [PubMed]
Brandis A, Aronica E, Goebel HH, TPM2 mutation. NEUROMUSCULAR DISORD 2008;18 (12):1005 [PubMed]
Brugman F, Scheffer H, Wokke JHJ, Nillesen WM, de Visser M, Aronica E, Veldink JH, van den Berg LH, Paraplegin mutations in sporadic adult-onset upper motor neuron syndromes. NEUROLOGY 2008;71 (19):1500-1505 [PubMed]
Budde BS, Namavar Y, Barth PG, Poll-The BT, Nürnberg G, Becker C, van Ruissen F, Weterman MAJ, Fluiter K, te Beek ET, Aronica E, van der Knaap MS, Höhne W, Toliat MR, Crow YJ, Steinlin M, Voit T, Roelens F, Brussel W, Brockmann K, Kyllerman M, Boltshauser E, Hammersen G, Willemsen M, Basel-Vanagaite L, Krägeloh-Mann I, de Vries LS, Sztriha L, Muntoni F, Ferrie CD, Battini R, Hennekam RCM, Grillo E, Beemer FA, Stoets LME, Wollnik B, Nürnberg P, Baas F, tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. NAT GENET 2008;40 (9):1113-1118 [PubMed]
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti F, The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders. NEUROCHEM RES 2008;33 (12):2401-2406 [PubMed]
D'Antoni S, Berretta A, Bonaccorso CM, Bruno V, Aronica E, Nicoletti F, Catania MV, Metabotropic glutamate receptors in glial cells. NEUROCHEM RES 2008;33 (12):2436-2443 [PubMed]
de Haan TR, Padberg RD, Hagebeuk EEO, Aronica E, van Rijn RR, Majoie CBLM, Kok JH, A case of neonatal dural sinus malformation: clinical symptoms, imaging and neuropathological investigations. EUR J PAEDIATR NEURO 2008;12 (1):41-45 [PubMed]
Fazio F, Notartomaso S, Aronica E, Storto M, Battaglia G, Vieira E, Gatti S, Bruno V, Biagioni F, Gradini R, Nicoletti F, Di Marco R, Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis. NEUROPHARMACOLOGY 2008;55 (4):491-499 [PubMed]
Ravizza T, Gagliardi B, Noé F, Boer K, Aronica E, Vezzani A, Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. NEUROBIOL DIS 2008;29 (1):142-160 [PubMed]
Stroes ES, Nierman MC, Meulenberg JJ, Franssen R, Twisk J, Henny CP, Maas MM, Zwinderman AH, Ross C, Aronica E, High KA, Levi MM, Hayden MR, Kastelein JJ, Kuivenhoven JA, Intramuscular Administration of AAV1-Lipoprotein Lipase(S447X) Lowers Triglycerides in Lipoprotein Lipase-Deficient Patients. ARTERIOSCL THROM VAS 2008;28 (12):2303-U264 [PubMed]
van der Kooi AJ, van Langen IM, Aronica E, van Doorn PA, Wokke JHJ, Brusse E, Langerhorst CT, Bergin P, Dekker LRC, Deprez RHLD, de Visser M, Extension of the clinical spectrum of Danon disease. NEUROLOGY 2008;70 (16):1358-1359 [PubMed]
van Heteren JT, Rozenberg F, Aronica E, Troost D, Lebon P, Kuijpers TW, Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in Aicardi-Goutières syndrome. GLIA 2008;56 (5):568-578 [PubMed]
Vezzani A, Ravizza T, Balosso S, Aronica E, Glia as a source of cytokines: implications for neuronal excitability and survival. EPILEPSIA 2008;49 (Suppl. 2):24-32 [PubMed]
Aronica E, Boer K, Baybis M, Yu J, Crino P, Co-expression of cyclin D1 and phosphorylated ribosomal S6 proteins in hemimegalencephaly. ACTA NEUROPATHOL 2007;114 (3):287-293 [PubMed]
Aronica E, Boer K, Redeker S, Spliet WGM, van Rijen PC, Troost D, Gorter JA, Differential expression patterns of chloride transporters, Na+-K+-2Cl--cotransporter and K+-Cl--cotransporter, in epilepsy-associated malformations of cortical development. NEUROSCIENCE 2007;145 (1):185-196 [PubMed]
Aronica E, Boer K, van Vliet EA, Redeker S, Baayen JC, Spliet WGM, van Rijen PC, Troost D, da Silva FHL, Wadman WJ, Gorter JA, Complement activation in experimental and human temporal lobe epilepsy. NEUROBIOL DIS 2007;26 (3):497-511 [PubMed]
Aronica E, Gorter JA, Gene expression profile in temporal lobe epilepsy. NEUROSCIENTIST 2007;13 (2):100-108 [PubMed]
Aronica E, Redeker S, Boer K, Spliet WGM, van Rijen PC, Gorter JA, Troost D, Inhibitory networks in epilepsy-associated gangliogliomas and in the perilesional epileptic cortex. EPILEPSY RES 2007;74 (1):33-44 [PubMed]
Barth PG, Aronica E, de Vries L, Nikkels PGJ, Scheper W, Hoozemans JJ, Poll-The BT, Troost D, Pontocerebellar hypoplasia type 2: a neuropathological update. ACTA NEUROPATHOL 2007;114 (4):373-386 [PubMed]
Boer K, Troost D, Spliet WGM, Redeker S, Crino PB, Aronica E, A neuropathological study of two autopsy cases of syndromic hemimegalencephaly. NEUROPATH APPL NEURO 2007;33 (4):455-470 [PubMed]
Busceti CL, Biagioni F, Aronica E, Riozzi B, Storto M, Battaglia G, Giorgi FS, Gradini R, Fornai F, Caricasole A, Nicoletti F, Bruno V, Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy. EPILEPSIA 2007;48 (4):694-705 [PubMed]
Catania MV, D'Antoni S, Bonaccorso CM, Aronica E, Bear MF, Nicoletti F, Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders?. MOL NEUROBIOL 2007;35 (3):298-307 [PubMed]
Ferrier CH, Aronica E, Leijten FSS, Spliet WGM, Boer K, van Rijen PC, van Huffelen AC, Electrocorticography discharge patterns in patients with a cavernous hemangioma and pharmacoresistent epilepsy. J NEUROSURG 2007;107 (3):495-503 [PubMed]
Gorter JA, van Vliet EA, Rauwerda H, Breit T, Stad R, van Schaik L, Vreugdenhil E, Redeker S, Hendriksen E, Aronica E, Lopes da Silva FH, Wadman WJ, Dynamic changes of proteases and protease inhibitors revealed by microarray analysis in CA3 and entorhinal cortex during epileptogenesis in the rat. EPILEPSIA 2007;48 (Suppl. 5):53-64 [PubMed]
Koot RW, Stalpers LJA, Aronica E, Bosch DA, Cerebral necrosis after 25 Gy radiotherapy in childhood followed 28 years later by 54 Gy radiotherapy. CLIN NEUROL NEUROSUR 2007;109 (7):607-612 [PubMed]
Lamparello P, Baybis M, Pollard J, Hol EM, Eisenstat DD, Aronica E, Crino PB, Developmental lineage of cell types in cortical dysplasia with balloon cells. BRAIN 2007;130 (Part 9):2267-2276 [PubMed]
Palma E, Roseti C, Maiolino F, Fucile S, Martinello K, Mazzuferi M, Aronica E, Manfredi M, Esposito V, Cantore G, Miledi R, Simonato M, Eusebi F, GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors. P NATL ACAD SCI USA 2007;104 (52):20944-20948 [PubMed]
Samadani U, Judkins AR, Akpalu A, Aronica E, Crino PB, Differential cellular gene expression in ganglioglioma. EPILEPSIA 2007;48 (4):646-653 [PubMed]
van Rootselaar AF, van der Salm SMA, Bour LJ, Edwards MJ, Brown P, Aronica E, Rozemuller-Kwakkel JM, Koehler PJ, Koelman JHTM, Rothwell JC, Tijssen MAJ, Decreased cortical inhibition and yet cerebellar pathology in 'familial cortical myoclonic tremor with epilepsy'. MOVEMENT DISORD 2007;22 (16):2378-2385 [PubMed]
van Vliet EA, da Costa Araújo S, Redeker S, van Schaik R, Aronica E, Gorter JA, Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. BRAIN 2007;130 (Part 2):521-534 [PubMed]
van Vliet EA, van Schaik R, Edelbroek PM, Voskuyl RA, Redeker S, Aronica E, Wadman WJ, Gorter JA, Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats. J PHARMACOL EXP THER 2007;322 (1):141-147 [PubMed]
Boer K, Spliet WGM, van Rijen PC, Redeker S, Troost D, Aronica E, Evidence of activated microglia in focal cortical dysplasia. J NEUROIMMUNOL 2006;173 (1-2):188-195 [PubMed]
Copani A, Hoozemans JJM, Caraci F, Calafiore M, van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F, DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid. J NEUROSCI 2006;26 (43):10949-10957 [PubMed]
Ferrier CH, Aronica E, Leijten FSS, Spliet WGM, van Huffelen AC, van Rijen PC, Binnie CD, Electrocorticographic discharge patterns in glioneuronal tumors and focal cortical dysplasia. EPILEPSIA 2006;47 (9):1477-1486 [PubMed]
Gorter JA, van Vliet EA, Aronica E, Breit T, Rauwerda H, Lopes da Silva FH, Wadman WJ, Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J NEUROSCI 2006;26 (43):11083-11110 [PubMed]
Iacovelli L, Arcella A, Battaglia G, Pazzaglia S, Aronica E, Spinsanti P, Caruso A, de Smaele E, Saran A, Gulino A, D'Onofrio M, Giangaspero F, Nicoletti F, Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas. J NEUROSCI 2006;26 (32):8388-8397 [PubMed]
Ozbas-Gerçeker F, Redeker S, Boer K, Ozgüç M, Saygi S, Dalkara T, Soylemezoglu F, Akalan N, Baayen JC, Gorter JA, Aronica E, Serial analysis of gene expression in the hippocampus of patients with mesial temporal lobe epilepsy. NEUROSCIENCE 2006;138 (2):457-474 [PubMed]
Ravizza T, Boer K, Redeker S, Spliet WGM, van Rijen PC, Troost D, Vezzani A, Aronica E, The IL-1beta system in epilepsy-associated malformations of cortical development. NEUROBIOL DIS 2006;24 (1):128-143 [PubMed]
van Vliet EA, van Schaik R, Edelbroek PM, Redeker S, Aronica E, Wadman WJ, Marchi N, Vezzani A, Gorter JA, Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. EPILEPSIA 2006;47 (4):672-680 [PubMed]
Aronica E, Gorter JA, Redeker S, Ramkema M, Spliet WGM, van Rijen PC, Leenstra S, Troost D, Distribution, characterization and clinical significance of microglia in glioneuronal tumours from patients with chronic intractable epilepsy. NEUROPATH APPL NEURO 2005;31 (3):280-291 [PubMed]
Aronica E, Gorter JA, Redeker S, van Vliet EA, Ramkema M, Scheffer GL, Scheper RJ, van der Valk P, Leenstra S, Baayen JC, Spliet WGM, Troost D, Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain. EPILEPSIA 2005;46 (6):849-857 [PubMed]
Aronica E, Gorter JA, Rozemuller AJ, Yankaya B, Troost D, Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1beta-stimulated release of IL-6 in cultured human astrocytes. NEUROSCIENCE 2005;130 (4):927-933 [PubMed]
Aronica E, Gorter JA, Rozemuller AJ, Yankaya B, Troost D, Interleukin-1 beta down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes. J NEUROIMMUNOL 2005;160 (1-2):188-194 [PubMed]
Aronica E, van Kempen AAMW, van der Heide M, Poll-The BT, van Slooten HJ, Troost D, Rozemuller-Kwakkel JM, Congenital disorder of glycosylation type Ia: a clinicopathological report of a newborn infant with cerebellar pathology. ACTA NEUROPATHOL 2005;109 (4):433-442 [PubMed]
Geurts JJG, Wolswijk G, Bö L, Redeker S, Ramkema M, Troost D, Aronica E, Expression patterns of group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions. J NEUROIMMUNOL 2005;158 (1-2):182-190 [PubMed]
Gorter JA, Mesquita ARM, van Vliet EA, da Silva FHL, Aronica E, Increased expression of ferritin, an iron-storage protein, in specific regions of the parahippocampal cortex of epileptic rats. EPILEPSIA 2005;46 (9):1371-1379 [PubMed]
Platania P, Seminara G, Aronica E, Troost D, Vincenza Catania M, Angela Sortino M, 17beta-estradiol rescues spinal motoneurons from AMPA-induced toxicity: a role for glial cells. NEUROBIOL DIS 2005;20 (2):461-470 [PubMed]
Siegel AM, Cascino GD, Elger CE, Devinsky O, Laff R, Najjar S, Sperling MR, LoRusso G, Cossu M, Urbach H, Aronica E, Meyer FB, Scheithauer BW, Dubeau F, Andermann F, Adult-onset epilepsy in focal cortical dysplasia of Taylor type. NEUROLOGY 2005;64 (10):1771-1774 [PubMed]
van Vliet EA, Redeker S, Aronica E, Edelbroek PM, Gorter JA, Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats. EPILEPSIA 2005;46 (10):1569-1580 [PubMed]
Yu J, Baybis M, Lee A, McKhann G 2nd, Chugani D, Kupsky WJ, Aronica E, Crino PB, Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling. BRAIN PATHOL 2005;15 (3):179-186 [PubMed]
Aronica E, Gorter JA, Ramkema M, Redeker S, Ozbas-Gerçeker F, van Vliet EA, Scheffer GL, Scheper RJ, van der Valk P, Baayen JC, Troost D, Ozbas-Gerçerer F, Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. EPILEPSIA 2004;45 (5):441-451 [PubMed]
Aronica E, Ozbas-Gerçeker F, Redeker S, Ramkema M, Spliet WGM, van Rijen PC, Leenstra S, Gorter JA, Troost D, Expression and cellular distribution of high- and low-affinity neurotrophin receptors in malformations of cortical development. ACTA NEUROPATHOL 2004;108 (5):422-434 [PubMed]
Baybis M, Lynch D, Lee A, Patel A, McKhann G 2nd, Chugani D, J Kupsky W, Aronica E, Crino PB, Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly. EPILEPSIA 2004;45 (12):1517-1524 [PubMed]
Baybis M, Yu J, Lee A, Golden JA, Weiner H, McKhann G 2nd, Aronica E, Crino PB, mTOR cascade activation distinguishes tubers from focal cortical dysplasia. ANN NEUROL 2004;56 (4):478-487 [PubMed]
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F, Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J NEUROSCI 2004;24 (26):6021-6027 [PubMed]
Ketelaars SOM, Gorter JA, Aronica E, Wadman WJ, Calcium extrusion protein expression in the hippocampal formation of chronic epileptic rats after kainate-induced status epilepticus. EPILEPSIA 2004;45 (10):1189-1201 [PubMed]
Ozbas-Gerçeker F, Gorter JA, Redeker S, Ramkema M, van der Valk P, Baayen JC, Ozgüç M, Saygi S, Soylemezoglu F, Akalin N, Troost D, Aronica E, Neurotrophin receptor immunoreactivity in the hippocampus of patients with mesial temporal lobe epilepsy. NEUROPATH APPL NEURO 2004;30 (6):651-664 [PubMed]
Spliet WGM, Aronica E, Ramkema M, Witmer AN, Schlingemann RO, de Jong JMBV, Troost D, Immunohistochemical localization of vascular endothelial growth factor receptors-1, -2 and -3 in human spinal cord: altered expression in amyotrophic lateral sclerosis. NEUROPATH APPL NEURO 2004;30 (4):351-359 [PubMed]
van Rootselaar AF, Aronica E, Jansen Steur ENH, Rozemuller-Kwakkel JM, de Vos RAI, Tijssen MAJ, Familial cortical tremor with epilepsy and cerebellar pathological findings. MOVEMENT DISORD 2004;19 (2):213-217 [PubMed]
van Vliet EA, Aronica E, Redeker S, Gorter JA, Expression and cellular distribution of major vault protein: a putative marker for pharmacoresistance in a rat model for temporal lobe epilepsy. EPILEPSIA 2004;45 (12):1506-1516 [PubMed]
van Vliet EA, Aronica E, Tolner EA, Lopes da Silva FH, Gorter JA, Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation. EXP NEUROL 2004;187 (2):367-379 [PubMed]
van Vliet E, Aronica E, Redeker S, Marchi N, Rizzi M, Vezzani A, Gorter J, Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. EPILEPSY RES 2004;60 (2-3):203-213 [PubMed]
Aronica E, Gorter JA, Ijlst-Keizers H, Rozemuller AJ, Yankaya B, Leenstra S, Troost D, Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. EUR J NEUROSCI 2003;17 (10):2106-2118 [PubMed]
Aronica E, Gorter JA, Jansen GH, van Veelen CWM, van Rijen PC, Leenstra S, Ramkema M, Scheffer GL, Scheper RJ, Troost D, Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: Focal cortical dysplasia and glioneuronal tumors. NEUROSCIENCE 2003;118 (2):417-429 [PubMed]
Aronica E, Gorter JA, Jansen GH, van Veelen CWM, van Rijen PC, Ramkema M, Troost D, Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in Taylor-type focal cortical dysplasia. EPILEPSIA 2003;44 (6):785-795 [PubMed]
Aronica E, Gorter JA, van Vliet EA, Spliet WGM, van Veelen CWM, van Rijen PC, Leenstra S, Ramkema MD, Scheffer GL, Scheper RJ, Sisodiya SM, Troost D, Overexpression of the human major vault protein in gangliogliomas. EPILEPSIA 2003;44 (9):1166-1175 [PubMed]
Aronica E, Troost D, Rozemuller AJ, Yankaya B, Jansen GH, Isom LL, Gorter JA, Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies. ACTA NEUROPATHOL 2003;105 (5):515-523 [PubMed]
Catania MV, Giuffrida R, Seminara G, Barbagallo G, Aronica E, Gorter JA, Dell'Albani P, Ravagna A, Calabrese V, Giuffrida-Stella AM, Upregulation of neuronal nitric oxide synthase in in vitro stellate astrocytes and in vivo reactive astrocytes after electrically induced status epilepticus. NEUROCHEM RES 2003;28 (3-4):607-615 [PubMed]
Geurts JJG, Wolswijk G, Bö L, van der Valk P, Polman CH, Troost D, Aronica E, Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis. BRAIN 2003;126 (Part 8):1755-1766 [PubMed]
Gorter JA, Gonçalves Pereira PM, van Vliet EA, Aronica E, Lopes da Silva FH, Lucassen PJ, Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. EPILEPSIA 2003;44 (5):647-658 [PubMed]
Spliet WGM, Aronica E, Ramkema M, Aten J, Troost D, Increased expression of connective tissue growth factor in amyotrophic lateral sclerosis human spinal cord. ACTA NEUROPATHOL 2003;106 (5):449-457 [PubMed]
Tolner EA, van Vliet EA, Holtmaat AJGD, Aronica E, Witter MP, da Silva FHL, Gorter JA, GAP-43 mRNA and protein expression in the hippocampal and parahippocampal region during the course of epileptogenesis in rats. EUR J NEUROSCI 2003;17 (11):2369-2380 [PubMed]
Gorter JA, van Vliet EA, Aronica E, Lopes da Silva FH, Long-lasting increased excitability differs in dentate gyrus vs. CA1 in freely moving chronic epileptic rats after electrically induced status epilepticus. HIPPOCAMPUS 2002;12 (3):311-324 [PubMed]
Gorter JA, van Vliet EA, Lopes da Silva FH, Isom LL, Aronica E, Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy. EUR J NEUROSCI 2002;16 (2):360-364 [PubMed]
Gorter JA, van Vliet EA, Proper EA, de Graan PNE, Ghijsen WEJM, Lopes da Silva FH, Aronica E, Glutamate transporters alterations in the reorganizing dentate gyrus are associated with progressive seizure activity in chronic epileptic rats. J COMP NEUROL 2002;442 (4):365-377 [PubMed]
Rizzi M, Caccia S, Guiso G, Richichi C, Gorter JA, Aronica E, Aliprandi M, Bagnati R, Fanelli R, D'Incalci M, Samanin R, Vezzani A, Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J NEUROSCI 2002;22 (14):5833-5839 [PubMed]
Vandeputte DAA, Troost D, Leenstra S, Ijlst-Keizers H, Ramkema M, Bosch DA, Baas F, Das NK, Aronica E, Expression and distribution of Id helix-loop-helix proteins in human astrocytic tumors. GLIA 2002;38 (4):329-338 [PubMed]
Aronica E, Catania MV, Geurts J, Yankaya B, Troost D, Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes. NEUROSCIENCE 2001;105 (2):509-520 [PubMed]
Aronica E, Gorter JA, Jansen GH, Leenstra S, Yankaya B, Troost D, Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. ACTA NEUROPATHOL 2001;101 (5):449-459 [PubMed]
Aronica E, Leenstra S, Jansen GH, van Veelen CW, Yankaya B, Troost D, Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor. ACTA NEUROPATHOL 2001;101 (4):383-392 [PubMed]
Aronica E, Leenstra S, van Veelen CW, van Rijen PC, Hulsebos TJ, Tersmette AC, Yankaya B, Troost D, Glioneuronal tumors and medically intractable epilepsy: a clinical study with long-term follow-up of seizure outcome after surgery. EPILEPSY RES 2001;43 (3):179-191 [PubMed]
Aronica E, Vandeputte DA, van Vliet EA, Lopes da Silva FH, Troost D, Gorter JA, Expression of Id proteins increases in astrocytes in the hippocampus of epileptic rats. NEUROREPORT 2001;12 (11):2461-2465 [PubMed]
Aronica E, van Vliet EA, Hendriksen E, Troost D, Lopes da Silva FH, Gorter JA, Cystatin C, a cysteine protease inhibitor, is persistently up-regulated in neurons and glia in a rat model for mesial temporal lobe epilepsy. EUR J NEUROSCI 2001;14 (9):1485-1491 [PubMed]
Aronica E, Yankaya B, Jansen GH, Leenstra S, van Veelen CW, Gorter JA, Troost D, Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy. NEUROPATH APPL NEURO 2001;27 (3):223-237 [PubMed]
Aronica E, Yankaya B, Troost D, van Vliet EA, Lopes da Silva FH, Gorter JA, Induction of neonatal sodium channel II and III alpha-isoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus. EUR J NEUROSCI 2001;13 (6):1261-1266 [PubMed]
Catania MV, Aronica E, Yankaya B, Troost D, Increased expression of neuronal nitric oxide synthase spliced variants in reactive astrocytes of amyotrophic lateral sclerosis human spinal cord. J NEUROSCI 2001;21 (11):RC148 [PubMed]
Gorter JA, van Vliet EA, Aronica E, Lopes da Silva FH, Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons. EUR J NEUROSCI 2001;13 (4):657-669 [PubMed]
Aronica E, van Vliet EA, Mayboroda OA, Troost D, da Silva FH, Gorter JA, Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy. EUR J NEUROSCI 2000;12 (7):2333-2344 [PubMed]
Aronica E, Dickson DW, Kress Y, Morrison JH, Zukin RS, Non-plaque dystrophic dendrites in Alzheimer hippocampus: a new pathological structure revealed by glutamate receptor immunocytochemistry. NEUROSCIENCE 1998;82 (4):979-991 [PubMed]
Aronica EM, Gorter JA, Grooms S, Kessler JA, Bennett MV, Zukin RS, Rosenbaum DM, Aurintricarboxylic acid prevents GLUR2 mRNA down-regulation and delayed neurodegeneration in hippocampal CA1 neurons of gerbil after global ischemia. P NATL ACAD SCI USA 1998;95 (12):7115-7120 [PubMed]
Aronica EM, Gorter JA, Paupard MC, Grooms SY, Bennett MV, Zukin RS, Status epilepticus-induced alterations in metabotropic glutamate receptor expression in young and adult rats. J NEUROSCI 1997;17 (21):8588-8595 [PubMed]
Gorter JA, Petrozzino JJ, Aronica EM, Rosenbaum DM, Opitz T, Bennett MV, Connor JA, Zukin RS, Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil. J NEUROSCI 1997;17 (16):6179-6188 [PubMed]
Aronica E, Costantini LC, Snyder-Keller A, Reciprocal influences of nigral cells and striatal patch neurons in dissociated co-cultures. J NEUROSCI RES 1996;44 (6):540-550 [PubMed]
Bennett MV, Pellegrini-Giampietro DE, Gorter JA, Aronica E, Connor JA, Zukin RS, The GluR2 hypothesis: Ca(++)-permeable AMPA receptors in delayed neurodegeneration. COLD SPRING HARB SYM 1996;61:373-384 [PubMed]
Gorter JA, Aronica E, Hack NJ, Balázs R, Wadman WJ, Development of voltage-activated potassium currents in cultured cerebellar granule neurons under different growth conditions. J NEUROPHYSIOL 1995;74 (1):298-306 [PubMed]
Aronica E, Condorelli DF, Nicoletti F, Dell'Albani P, Amico C, Balázs R, Metabotropic glutamate receptors in cultured cerebellar granule cells: developmental profile. J NEUROCHEM 1993;60 (2):559-565 [PubMed]
Aronica E, Dell'Albani P, Condorelli DF, Nicoletti F, Hack N, Balázs R, Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors. MOL PHARMACOL 1993;44 (5):981-989 [PubMed]
Aronica E, Nicoletti F, Condorelli DF, Balázs R, Pharmacological characterization of metabotropic glutamate receptors in cultured cerebellar granule cells. NEUROCHEM RES 1993;18 (5):605-612 [PubMed]
Condorelli DF, Dell'Albani P, Aronica E, Genazzani AA, Casabona G, Corsaro M, Balázs R, Nicoletti F, Growth conditions differentially regulate the expression of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunits in cultured neurons. J NEUROCHEM 1993;61 (6):2133-2139 [PubMed]
Aleppo G, Pisani A, Copani A, Bruno V, Aronica E, D'Agata V, Canonico PL, Nicoletti F, Metabotropic glutamate receptors and neuronal toxicity. ADV EXP MED BIOL 1992;318:137-145 [PubMed]
Aronica E, Casabona G, Genazzani AA, Catania MV, Contestabile A, Virgili M, Nicoletti F, Melittin enhances excitatory amino acid release and AMPA-stimulated 45Ca2+ influx in cultured neurons. BRAIN RES 1992;586 (1):72-77 [PubMed]
Aronica E, Frey U, Wagner M, Schroeder H, Krug M, Ruthrich H, Catania MV, Nicoletti F, Reymann KG, Enhanced sensitivity of "metabotropic" glutamate receptors after induction of long-term potentiation in rat hippocampus. J NEUROCHEM 1991;57 (2):376-383 [PubMed]
Canonico PL, Aronica E, Aleppo G, Casabona G, Copani A, Favit A, Nicoletti F, Scapagnini U, Repeated injections of piracetam improve spatial learning and increase the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in aged rats. FUNCT NEUROL 1991;6 (2):107-111 [PubMed]
Catania MV, Aronica E, Sortino MA, Canonico PL, Nicoletti F, Desensitization of metabotropic glutamate receptors in neuronal cultures. J NEUROCHEM 1991;56 (4):1329-1335 [PubMed]
Copani A, Canonico PL, Catania MV, Aronica E, Bruno V, Ratti E, van Amsterdam FT, Gaviraghi G, Nicoletti F, Interaction between beta-N-methylamino-L-alanine and excitatory amino acid receptors in brain slices and neuronal cultures. BRAIN RES 1991;558 (1):79-86 [PubMed]
Aronica E, Nicoletti F, Canonico PL, Activation of excitatory amino acid receptors increases intracellular free [3H]arachidonate levels in cultured cerebellar neurons. FUNCT NEUROL 1990;5 (1):15-20 [PubMed]
Aronica E, Reymann K, Frey U, Krug M, Wagner M, Schroeder H, Catania MV, Nicoletti F, Enhanced sensitivity of "metabotropic" glutamate receptors after induction of long-term potentiation (LTP) in rat hippocampus. PHARMACOL RES 1990;22 (Suppl. 3):50-51 [PubMed]
Canonico PL, Aronica E, Bruno V, Catania MV, Aleppo G, Galavotti F, Nicoletti F, Pyrrolidone-carboxylic acid magnesium salt (PCA-Mg2+) protects against seizures induced by excitatory amino acids. FUNCT NEUROL 1990;5 (2):121-126 [PubMed]
Catania MV, Aronica E, Sortino MA, Canonico PL, Nicoletti F, Homologous desensitization of metabolotropic glutamate receptors in neuronal cultures. PHARMACOL RES 1990;22 (Suppl. 1):79-80 [PubMed]
Key publications

van Scheppingen J, Iyer AM, Prabowo AS, Mühlebner A, Anink JJ, Scholl T, Feucht M, Jansen FE, Spliet WG, Krsek P, Zamecnik J, Buccoliero AM, Giordano F, Genitori L, Kotulska K, Jozwiak S, Jaworski J, Liszewska E, van Vliet EA, Aronica E, Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA-derived cell cultures. GLIA 2016;64 (6):1066-1082 [PubMed]
Gorter JA, Iyer A, White I, Colzi A, van Vliet EA, Sisodiya S, Aronica E, Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy. NEUROBIOL DIS 2014;62:508-520 [PubMed]
Zurolo E, Iyer A, Maroso M, Carbonell C, Anink JJ, Ravizza T, Fluiter K, Spliet WGM, van Rijen PC, Vezzani A, Aronica E, Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. BRAIN 2011;134 (Part 4):1015-1032 [PubMed]
Iyer A, Zurolo E, Prabowo A, Fluiter K, Spliet WGM, van Rijen PC, Gorter JA, Aronica E, MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response. PLOS ONE 2012;7 (9):e44789 [PubMed]
Boison D, Aronica E, Comorbidities in Neurology: Is adenosine the common link?. NEUROPHARMACOLOGY 2015;97:18-34 [PubMed]


All Publications

Curriculum Vitae

Eleonora Aronica completed her MD and Neurology residency at the University of Catania (Italy). After receiving a doctorate from the UvA (1993) she moved to the USA, where she had research associated appointments in Albany and New York. Subsequently, she moved to The Netherlands and joined the Department of Neuropathology of AMC at the UvA, where she completed the Neuropathology residence program. In 2012 she was appointed  Professor by Special Appointment of the Pathology of the Nervous System, focusing on epileptic conditions at the University of Amsterdam’s (UvA) Faculty of Science (FNWI).  In 2016 she was appointed  Professor of Neuropathology at at the University of Amsterdam's Faculty of Medicine (AMC-UvA).  She is actively involved in the different research lines, including neuro-oncology, neurodegeneration, developmental disorders and epilepsy. She leads a research group focused on translational research into Epilepsy and aiming to understand the pathogenesis, epileptogenesis and pharmacoresistance of human focal chronic pharmacoresistant epilepsy. Her research has been focused on the search for effective treatment for patients with epilepsy by delineating the biological and molecular pathways that contribute to development and progression of epilepsy (epileptogenesis) in patients with focal epilepsy, including patients with malformations of cortical development (MCD). She ILAE task force member. Her scientific honours include the Michael Prize (2011) for the best scientific and clinical research in the field of epilepsy.  She is the author of more than 300 peer-reviewed original articles.

 

 

 

 

 

 

 

 

 

Research programmes

Neuron-glia interactions in health and disease and inflammation

In 2007, international collaborations have been established to further investigate the role of astroglial and microglial cells in the initiation and persistence of the inflammatory response associated with neuronal degeneration and hyperexcitability (Grant of the European Union: HEALTH-2007-2.2.1-6:“ Neuron-glia interactions in health and disease”; www.neuroglia.eu ). This has been investigated in human brain and in well established animal models of epilepsy. 

2012-2015:. Grant of the European Union: HEALTH.2011.2.2.2-2 " Pathways common to brain development and ageing: defining strategies for preventive therapy and diagnostics “
Objectives
a. To examine neurodegeneration-related proteins during development: comparing early and postnatal developmental stages in developmental disorders
b. To examine the relationship between neurodegeneration-related proteins and specific developmental pathways
c. To study selected altered mRNAs, microRNAs and proteins in focal cortical malformations

 2012-2016: Characterization of genetic aberrations in pediatric low-grade glioneuronal tumors Stichting Kinderen Kankervrij (KiKa).
The aim of the study is to identify chromosomal changes in an international large series of GNT’s by genomic wide microarray based comparative genomic hybridization (aCGH), PCR and genomic sequencing. During the project these chromosomal changes will be investigated for their potential clinical relevance as related to prognosis, pathogenesis en epileptogenesis. The miRNA profile of GNT’s will be also evaluated. By investigating these biologic characteristics in relation to the clinical data, we can improve the diagnostics and therapy for GNT’s in children, as guided by the clinical biological risk profile of the tumor.

2013-2017: National Epilepsy Fonds (NEF): miRNA and inflammation: new opportunities for therapy in epilepsy associated pathologies. Recent clinical-neuropathological and experimental observations support the notion that a dysregulation of the astrocyte immune-inflammatory function represents a common factor, which may predispose or directly contribute to the generation of seizures and to seizure-related neuronal damage in epilepsy of various aetiologies.
Since specific miRNAs have been recently shown to regulate the immune/inflammatory responses, our strategy is devoted to identify key miRNAs that may act as regulators of specific pro-inflammatory/ pro-epileptogenic pathways and to study the effects of their modulation and its therapeutic potential in epilepsy, using a multidisciplinary approach. 

 2013-2017: National Epilepsy Fonds (NEF): Towards effective surgery in focal cortical dysplasias: histopathology, EEG and 7T MRI characteristics. The aim of this proposal is three-fold.First, we want to improve the prediction of postoperative outcome, by elucidating the clinico-pathological correlates of FCD subtypes.

 2013-2018: Grant of the European Union: FP7-HEALTH-2013-INNOVATION-(HEALTH.2013.2.2.1-4: Patho-physiology and therapy of epilepsy and epileptiform disorders): “Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – tuberous sclerosis complex”. EPISTOP.

The aim of EPISTOP is to better understand the pathophysiology of epilepsy and its consequences, to develop a preventative strategy for epilepsy, to identify new biomarkers of epilepsy, and to develop new therapeutic targets to block or otherwise modify epileptogenesis in humans.
To achieve this aim, the risk factors and biomarkers of epilepsy will be identified by a multidisciplinary, systematic approach in three settings:
- a prospective study of epilepsy development in infants with TSC, using a wide range of clinical, neuroimaging, and genetic analyses, including a diverse set of cutting edge analyses of blood samples, that will be obtained at study entry, at the onset of epileptiform discharges on EEG, at seizure onset and at the age of 24 months.
- prospective clinical study of TSC infants treated with antiepileptic drugs at the onset of subclinical seizures in comparison to children treated only after clinical seizures appear, evaluating the benefit of preventative antiepileptic treatment and the possible mechanisms of epilepsy prevention
- analysis of biomarkers of epileptogenesis and drug-resistant epilepsy in epileptogenic brain specimens obtained from patients with TSC who underwent epilepsy surgery and TSC autopsy cases collected in the past.
 

 2013-2018: Grant of the European Union: FP7-HEALTH-2013-INNOVATION-(HEALTH.2013.2.2.1-4: Patho-physiology and therapy of epilepsy and epileptiform disorders): “Targets and biomarkers for antiepileptogenesis”. EPITARGET.

This multi- and transdisciplinary project is therefore focused on the processes leading to epilepsy (i.e. epileptogenesis) in adult brain. Epileptogenesis is a complex multifactorial pathologic process, characterized by the concomitant or sequential occurrence of multiple changes in the brain. A major conceptual originality of this project is to consider the underlying patho-physiologic mechanisms of epileptogenesis as temporally evolving multiple processes, even after the epileptic seizures occur and become recurrent.

Overall scientific objectives of  EPITARGET are:
Using multidisciplinary strategies of basic, preclinical and clinical research to:
1. identify novel biomarkers and their combinations that will characterize the different stages of epileptogenesis and predict/diagnose early and late stages of the evolution of the disease.
2. unravel the complex patho-physiology of epileptogenesis and to design new, disease-modifying combinatorial treatment strategies specifically targeted to the different stages of epileptogenesis.
3. translate the knowledge obtained in experimental models to patients in order to improve diagnosis, achieve better patient stratification, and develop new antiepileptogenic treatments and means to predict their efficacy.

Projects 2016-2017:

  1. The extracellular matrix in epileptogenesis  Innovative Training Networks (ITN) Call: H2020-MSCA-ITN-2014 “ECMED”: (642881; 2015-2018); National Epilepsy Fonds (NEF; 2016-2020).
  2. Joint Programme - Neurodegenerative Disease Research ”European research projects for Cross-Disease Analysis of Pathways related to Neurodegenerative Diseases” (2015-2018).
  3. Stichting Kinderen Kankervrij (KiKa): Multi-platform analysis of TSC Subependymal Giant Cell Astrocytoma (SEGA) to identify novel therapeutic approaches  (2016-2020).
  4. Ministero della Salute (sezione Ricerca Sanitaria): Project Type: Italian researcher abroad. PE-2013-02355126: Homer-mGlu5 scaffold as common abnormal mechanism and therapeutic target for Intellectual Disability (ID) and Autism (2016-2019).      Theme: Neurological and Psychiatric Disorders
  5. 2016-2020: Subsidie Stichting "Michelle" (Tuberous Sclerosis)
  6. 2016-2017: Stichting Koppie-AU: MeMo studie Medulloblastoom, moleculaire biologie voor een betere risicoclassificatie bij kinderen .
  7. 2017-2021: H2020-MSCA-ITN-2016; EU-GliaPhD: Training, Research and Raising of Public Awareness in Cell Biology and Pathology of Neuroglia (722053)
  8.  2016-2019: Neuro-MIG COST Action (European Cooperation in the field of Scientific and Technical Research): OC-2016-1-20862 European Network on Brain Malformations.
  9. 2017-2018: Stichting Knip: Epileptogene Glioneuronale tumoren: “Moleculaire biologie en classificatie”.
  10. 2017-2022: Gezamenlijk Programma Translationeel Onderzoek tussen ZonMw, Stichting LSH-TKI en de Samenwerkende Gezondheidsfondsen. Projecttitel: Molecular diagnostics for personalized epilepsy surgery evaluation and prognosis.
     

Societal impact activiteit:

Interview Develage interview: https://www.youtube.com/watch?v=yLvsv3fmER8 Interview ILAE: focal lesions and epilepsy. http://www.ilae.org/Visitors/MeetingProceedings/29thiecvideos.cfm New York Times: New Epilepsy Tactic: Fight Inflammation: http://www.nytimes.com/2012/06/05/health/research/new-epilepsy-tactic-fight-inflammation.html?pagewanted=all&_r=0
 Impact magazine: http://www.epistop.eu/index.php/news/137-impact-publication-epistop

Books (2011-2016):
Annamaria Vezzani, Stephan Auvin, Teresa Ravizza, Eleonora Aronica Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012
Eleonora Aronica, Werner Stenzel. Reactions of muscle to toxins and drugs. Muscle Disease: Pathology and Genetics - Second Edition. International Society of Neuropathology (ISN) Book Series, 2014.
Clinical Neuroembryology: Development and developmental disorders of the human central nervous system, second edition (2014). Chapter10.7.4 Disorders of Cortical Development and Epilepsy.
Eleonora Aronica and Angelika Mühlebner. Handbook of Clinical Neurology 3rd Series: Neuropathology of Epilepsy (2016).
Eleonora Aronica, Angelika Mühlebner, Erwin van Vliet and Jan GorterModels of Seizure and Epilepsy, Second Edition Technical and methodological issues. Characterization of pathology (2016) .
Nikolay Kuzmin, Sander Idema, Eleonora Aronica, Philip C. de Witt Hamer, Pieter Wesseling, Marie Louise Groot. Higher Harmonic Generation Imaging for NeuroPathology (Taylor & Francis) Neurophotonics (2016).
M. de Visser and E. Aronica. Histopathological Features of Idiopathic Inflammatory Myopathies Myositis (Oxford Rheumatology Library, 2016).
Heidrun Potschka and Eleonora Aronica. Pathophysiology of drug refractoriness. The Atlas of Epilepsies. Springer-Verlag Berlin Heidelberg. DOI: 10.1007/SpringerReference_188157 2011-05-09 09:18:39 UTC, 2011.
Eleonora Aronica and Pitt Niehusmann. Gangliogliomas: molecular pathogenesis and epileptogenesis. Tumors Of The Central Nervous System. Ed. M. A. Hayat, Springer, 2011.
Çiğdem Özkara and Eleonora Aronica. Hippocampal sclerosis. Handbook of Clinical Neurology (3rd Series). Elsevier, Handb Clin Neurol.108:621-39, 2012.
 

1. Commissielid: International League Against Epilepsy (ILAE)Task Force of the Diagnostic Methods Commission.
2. Tutor/Trekker: neuropathology teaching course aimed at colleagues engaged in the diagnostic evaluation of patients with drug-resistant focal epilepsy. http://www.ilae.org/Visitors/Congress/Ed-INES.cfm
3. Contribution to the 193rd ENMC (European Neuromuscluar center) workshop on pathology diagnosis of idiopathic inflammatory myopathies.


 

Faculty
Prof. E.M.A. Aronica

Postdocs
A.M. Iyer PhD
J.D. Mills
Dr. A. Mühlebner
Dr. E.A. van Vliet

PhD Students
A. Bongaarts MSc
D.W.M. Broekaart
N.L. Fransen
V. Iori BSc
V.A. Korotkov
J. van Scheppingen MSc
T.S. Zimmer
T.J. Veersema MD (UMCU)

Others
J.J. Anink

Other research related activities
  • Membership of medical or scientific committee, Netherlands Society of Neuropathology (NVVNP)
  • Membership of medical or scientific committee, Federation of European Neuroscience Societies
  • Membership of medical or scientific committee, American Society for Neuroscience
  • Membership of medical or scientific committee, British Neuropathological society
  • Contribution to guidelines and protocols, International League Against Epilepsy (ILAE)Task Force of the Diagnostic Methods Commission
  • Membership of medical or scientific committee, Scientific Research Section (SWO) of the Dutch League against Epilepsy
  • Membership of medical or scientific committee, Graduate School Neurosciences Amsterdam Rotterdam (ONWAR)
  • Membership of editorial board / Editorship, NEUROSCIENCE
  • Membership of editorial board / Editorship, FRONTIERS IN NEUROLOGY
Current research funding
  • AMC
  • Europese Unie
  • Izumi Biosciences, Inc.
  • Nationaal Epilepsie Fonds
  • New York University School of Medicine
  • RWTH Aachen University Hospital
  • Stichting ALS Nederland
  • Stichting AMC Foundation (Vrijgesteld)
  • Stichting KIKA
  • Stichting Margaret Olivia Knip
  • Stichting Michelle
  • UCB Biopharma SPRL
  • ZonMw