• Principal Investigator
  • Male

Dr. J. Crezee PhD

Position: Scientific staff member (UD)
Main activities: Research
Specialisation: Hyperthermia
foto J. Crezee is one of the AMC Principal Investigators
Focus of research:

Hyperthermia (HT) research with main focus on:

1) The development of new hyperthermia techniques, for both superficial and locoregional hyperthermia. Goals are optimal 3-D steering and (non-invasive) thermometry. Existing techniques are often incapable of achieving the tumour goal temperature without overheating normal tissue. New 3-D steered hyperthermia systems are developed to overcome this problem. Final step is commercialisation of equipment to achieve worldwide application of our equipment and to facilitate and promote high quality application of hyperthermia.

2) The development and application of hyperthermia treatment planning to improve and optimize the clinical temperature distribution. Modern phased array regional hyperthermia systems consist of large numbers of independent antennas yielding many degrees of freedom and therefore not easy to achieve optimal settings by intuitive settings. Computational optimization is indispensible but challenging due to uncertainty in tissue properties and perfusion values. Part of investigations are dedicated to improving planning by acquisition of more accurate tissue and perfusion properties by MRI. Another part focusses on the application of online adaptive planning during hyperthermia treatment. Finally biological modelling aiming at integration of radiotherapy and hyperthermia treatment planning.

3) Clinical research to establish the clinical value of hyperthermia for different tumour sites by setting up or contributing to pilot studies and randomised phase II and phase III clinical trials comparing standard radiotherapy and/or chemotherapy to radiotherapy and/or chemotherapy plus hyperthermia. Sites include breast, cervix, bladder, pancreas. Providing high level evidence is crucial for the clinical acceptance of Hyperthermia. Example. the HyperCR study for recurrent breast cancer, comparing RT+HT+/-CDDP

4) Fundamental research into the Working Mechanisms of Hyperthermia. Includes development of small animal hyperthermia device to study various working mechanisms in an orthotopic small animal model (mouse) in collaboration with various Dutch institutes. This knowledge thus gained is utilised in topics 1-3 of this research line.
 

Project leader for a number of research projects funded by the Dutch Cancer Society KWF:

- Development of a dual modality heating technique for treatment of cancer at the esophagus (AMC 2002-2622), project leaders J Crezee, N. van Wieringen, G van Tienhoven: € 423.363,-

- Optimisation of regional hyperthermia delivery using a newly developed 3-D hyperthermia system and advanced hyperthermia treatment planning techniques (UVA 2006-3484), project leaders J Crezee, MCCM Hulshof, JB van de Kamer: € 461.914,-

- An improved temperature measurement technique to be used during hyperthermia treatment of cancer at superficial locations may improve clinical results (UVA 2007-3841), project leaders J Crezee, Nvan Wieringen, G van Tienhoven: € 262.000,-

- Improved regional hyperhtermia delivery using hyperthermia treatment planning based on MRI data to predict and suppress treatment limiting hot spots (UVA 2010-4660), project leaders J Crezee, AJ Nederveen, LJA Stalpers: € 319.600,-

- Active hot spot suppression to improve thermal dose and clinical outcome of locoregional hyperthermia (UVA 2012-5393), project leaders J Crezee, HP Kok, LJA Stalpers: € 339.300,-

- Optimization of bladder hyperthermia treatment for NMIBC by using loco-regional heating, improved thermometry and 3D hyperthermia treatment planning (UVA 2012-5539), project leaders J Crezee, MCCM Hulshof, TM de Reijke: € 417.000,-

- MRI based hyperthermia treatment planning for improved hyperthermia delivery in cervical cancer patients (UVA 2014-7197), project leaders J Crezee, ALHMW van Lier, LJA Stalpers: € 572.500,-

- Irreversible electroporation for locally advanced pancreatic cancer; optimization of clinical treatment by advanced treatment planning (UVA 2014-7244), project leaders MGH Besselink, J Crezee, TM van Gulik: € 523.100,-

- Hyperthermia induced synthetic lethality combined with PARP1 inhibition to sensitize radiotherapy and CDDP treatment of Cervical cancer (UVA 2015-7820) project leaders NAP Franken, LJA Stalpers, J Crezee: € 485.600,-

- Development of patient specific treatment planning to enhance and optimize clinical effectiveness of hyperthermic intraperitoneal chemotherapy in colorectal cancer patients (UVA 2017-10595) project leaders J Crezee, NAP Franken, HP Kok, PJ Tanis: € 563.765,-

- Clinical evaluation of the benefit of planning based steering to improve effectiveness of hyperthermia in cervical cancer patients (UVA 2017-10873) project leaders HP Kok, J Crezee, LJA Stalpers: € 326.486.-

Project leader for

- investment grant NWO-ZonMw medium “A dedicated high resolution small animal hyperthermia device to support translation of novel cancer therapies from lab to bedside” (project 40-00506-98-16015, principal applicant J. Crezee, co-applicant N.A.P. Franken): € 443.250,-

- KiKa project 253 “Radiotherapy and hyperthermia for children: from concept to breakthrough?”. Project leaders A. Bel, J. Crezee, C.R.N. Rasch, H.J. Merks: € 78.762,-.

AMC themes: Oncology
Departments: Radiotherapy
Bakker A, Kolff MW, Holman R, van Leeuwen CM, Korshuize-van Straten L, de Kroon-Oldenhof R, Rasch CRN, van Tienhoven G, Crezee H, Thermal Skin Damage During Reirradiation and Hyperthermia Is Time-Temperature Dependent. INT J RADIAT ONCOL 2017;98 (2):392-399 [PubMed]
Balidemaj E , van den Berg CAT, van Lier ALHMW, Nederveen AJ, Stalpers LJA, Crezee H, Remis RF, B1-based SAR reconstruction using contrast source inversion-electric properties tomography (CSI-EPT). MED BIOL ENG COMPUT 2017;55 (2):225-233 [PubMed]
Crezee J, van Tienhoven G, Kolff MW, Sijbrands J, van Stam G, Oldenborg S, Geijsen ED, Hulshof MCCM, Kok HP, Development of a 70 MHz unit for hyperthermia treatment of deep-seated breast tumors. INT J MICROW WIREL T 2017;9 (6):1317-1324
Dobsicek Trefna H, Crezee H, Schmidt M, Marder D, Lamprecht U, Ehmann M, Hartmann J, Nadobny J, Gellermann J, van Holthe N, Ghadjar P, Lomax N, Abdel-Rahman S, Bert C, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, van Rhoon GC, Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirements. INT J HYPERTHER 2017;33 (4):471-482 [PubMed]
Dobšíček Trefná H, Crezee J, Schmidt M, Marder D, Lamprecht U, Ehmann M, Nadobny J, Hartmann J, Lomax N, Abdel-Rahman S, Curto S, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, van Rhoon GC, Quality assurance guidelines for superficial hyperthermia clinical trials : II. Technical requirements for heating devices Leitlinien zur Qualitätssicherung der lokalen Hyperthermie in klinischen Studien : II. Technische Anforderungen an Heizgeräte. STRAHLENTHER ONKOL 2017;193 (5):351-366 [PubMed]
Klaver CEL, Stam R, Sloothaak DAM, Crezee J, Bemelman WA, Punt CJA, Tanis PJ, Colorectal cancer at high risk of peritoneal metastases: long term outcomes of a pilot study on adjuvant laparoscopic HIPEC and future perspectives. ONCOTARGET 2017;8 (31):51200-51209 [PubMed]
Kok HP, Crezee J, A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia. INT J HYPERTHER 2017;33 (4):378-386 [PubMed]
Kok HP, Korshuize-van Straten L, Bakker A, de Kroon-Oldenhof R, Geijsen ED, Stalpers LJA, Crezee J, Online Adaptive Hyperthermia Treatment Planning During Locoregional Heating to Suppress Treatment-Limiting Hot Spots. INT J RADIAT ONCOL 2017;99 (4):1039-1047 [PubMed]
Kok HP, Kotte ANTJ, Crezee J, Planning, optimisation and evaluation of hyperthermia treatments. INT J HYPERTHER 2017;33 (6):593-607 [PubMed]
Oei AL, Ahire VR, van Leeuwen CM, ten Cate R, Stalpers LJA, Crezee J, Kok HP, Franken NAP, Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i. INT J HYPERTHER 2017;ahead of print [PubMed]
Oei AL, van Leeuwen CM, Ahire VR, Rodermond HM, ten Cate R, Westermann AM, Stalpers LJA, Crezee J, Kok HP, Krawczyk PM, Kanaar R, Franken NAP, Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia. ONCOTARGET 2017;8 (17):28116-28124 [PubMed]
Oei AL, Vriend LEM, Krawczyk PM, Horsman MR, Franken NAP, Crezee J, Targeting therapy-resistant cancer stem cells by hyperthermia. INT J HYPERTHER 2017;33 (4):419-427 [PubMed]
Oei AL, Vriend LEM, van Leeuwen CM, Rodermond HM, ten Cate R, Westermann AM, Stalpers LJA, Crezee J, Kanaar R, Kok HP, Krawczyk PM, Franken NAP, Sensitizing thermochemotherapy with a PARP1-inhibitor. ONCOTARGET 2017;8 (10):16303-16312 [PubMed]
van Leeuwen CM, Crezee J, Oei AL, Franken NAP, Stalpers LJA, Bel A, Kok HP, 3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments. INT J HYPERTHER 2017;33 (2):160-169 [PubMed]
van Leeuwen CM, Oei AL, Chin KWTK, Crezee J, Bel A, Westermann AM, Buist MR, Franken NAP, Stalpers LJA, Kok HP, A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer. RADIAT ONCOL 2017;12 (1):75 [PubMed]
van Leeuwen CM, Oei AL, ten Cate R, Franken NAP, Bel A, Stalpers LJA, Crezee J, Kok HP, Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation. INT J HYPERTHER 2017;ahead of print [PubMed]
van Stam G, Kok HP, Hulshof MCCM, Kolff MW, van Tienhoven G, Sijbrands J, Bakker A, Zum Vörde Sive Vörding PJ, Oldenborg S, de Greef M, Rasch CRN, Crezee H, A flexible 70 MHz phase-controlled double waveguide system for hyperthermia treatment of superficial tumours with deep infiltration. INT J HYPERTHER 2017;33 (7):796-809 [PubMed]
Vogel JA, van Veldhuisen E, Agnass P, Crezee J, Dijk F, Verheij J, van Gulik TM, Meijerink MR, Vroomen LG, van Lienden KP, Besselink MG, Time-Dependent Impact of Irreversible Electroporation on Pancreas, Liver, Blood Vessels and Nerves: A Systematic Review of Experimental Studies (vol 11, e0166987, 2016). PLOS ONE 2017;12 (3):e0174018 [PubMed]
Balidemaj E. MR based electric properties imaging for hyperthermia treatment planning and MR safety purposes. S.l.: s.n.; 2016. 131p. ISBN 978-94-028-0165-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Rasch CRN, Stalpers LJA; copromotor(s): Crezee J, Remis RF)
Balidemaj E, de Boer P, van Lier ALHMW, Remis RF, Stalpers LJA, Westerveld GH, Nederveen AJ, van den Berg CAT, Crezee J, In vivo electric conductivity of cervical cancer patients based on B₁⁺ maps at 3T MRI. PHYS MED BIOL 2016;61 (4):1596-1607 [PubMed]
Balidemaj E , Kok HP, Schooneveldt G, van Lier ALHMW, Remis RF, Stalpers LJA, Westerveld H, Nederveen AJ, van den Berg CAT, Crezee J, Hyperthermia treatment planning for cervical cancer patients based on electrical conductivity tissue properties acquired in vivo with EPT at 3 T MRI. INT J HYPERTHER 2016;32 (5):558-568 [PubMed]
Crezee H, Inman BA, The use of hyperthermia in the treatment of bladder cancer. INT J HYPERTHER 2016;32 (4):349-350 [PubMed]
Crezee H, van Leeuwen CM, Oei AL, Stalpers LJA, Bel A, Franken NA, Kok HP, Thermoradiotherapy planning: Integration in routine clinical practice. INT J HYPERTHER 2016;32 (1):41-49 [PubMed]
Crezee J, van Leeuwen CM, Oei AL, van Heerden LE, Bel A, Stalpers LJA, Ghadjar P, Franken NAP, Kok HP, Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer. RADIAT ONCOL 2016;11 (1):14 [PubMed]
Franken NAP, Kok HP, Crezee J, Barendsen GW, Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation. INT J RADIAT BIOL 2016;92 (9):521-526 [PubMed]
Liem EIML, Crezee H, de la Rosette JJ, de Reijke TM, Chemohyperthermia in non-muscle-invasive bladder cancer: An overview of the literature and recommendations. INT J HYPERTHER 2016;32 (4):363-373 [PubMed]
Oldenborg S, Valk C, van Os R, Oei B, Venselaar J, Vörding PZVS, van Randen A, Crezee H, van Tienhoven G, Rasch C, Rib fractures after reirradiation plus hyperthermia for recurrent breast cancer: Predictive factors. STRAHLENTHER ONKOL 2016;192 (4):240-247 [PubMed]
Schooneveldt G, Bakker A, Balidemaj E , Chopra R, Crezee J, Geijsen ED, Hartmann J, Hulshof MCCM, Kok HP, Paulides MM, Sousa-Escandon A, Stauffer PR, Maccarini PF, Thermal dosimetry for bladder hyperthermia treatment. An overview. INT J HYPERTHER 2016;32 (4):417-433 [PubMed]
Schooneveldt G, Kok HP, Balidemaj E, Geijsen ED, van Ommen F, Sijbrands J, Bakker A, de la Rosette JJMCH, Hulshof MCCM, de Reijke TM, Crezee J, Improving hyperthermia treatment planning for the pelvis by accurate fluid modeling. MED PHYS 2016;43 (10):5442 [PubMed]
Vogel JA, van Veldhuisen E, Agnass P, Crezee J, Dijk F, Verheij J, van Gulik TM, Meijerink MR, Vroomen LG, van Lienden KP, Besselink MG, Time-Dependent Impact of Irreversible Electroporation on Pancreas, Liver, Blood Vessels and Nerves: A Systematic Review of Experimental Studies. PLOS ONE 2016;11 (11):e0166987 [PubMed]
Balidemaj E , van den Berg CAT, Trinks J, van Lier ALHMW, Nederveen AJ, Stalpers LJA, Crezee H, Remis RF, CSI-EPT: A Contrast Source Inversion Approach for Improved MRI-Based Electric Properties Tomography. IEEE T MED IMAGING 2015;34 (9):1788-1796 [PubMed]
Balidemaj E , van Lier ALHMW, Crezee H, Nederveen AJ, Stalpers LJA, van den Berg CAT, Feasibility of electric property tomography of pelvic tumors at 3T. MAGN RESON MED 2015;73 (4):1505-1513 [PubMed]
Cihoric N, Tsikkinis A, van Rhoon G, Crezee H, Aebersold DM, Bodis S, Beck M, Nadobny J, Budach V, Wust P, Ghadjar P, Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry. INT J HYPERTHER 2015;31 (6):609-614 [PubMed]
Datta NR, Ordóñez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S, Local hyperthermia combined with radiotherapy and-/or chemotherapy: recent advances and promises for the future. CANCER TREAT REV 2015;41 (9):742-753 [PubMed]
Geijsen ED, de Reijke TM, Koning CC, Zum Vörde Sive Vörding PJ, de la Rosette JJ, Rasch CR, van Os RM, Crezee J, Combining Mitomycin C and Regional 70 MHz Hyperthermia in Patients with Nonmuscle Invasive Bladder Cancer: A Pilot Study. J UROLOGY 2015;194 (5):1202-1208 [PubMed]
Kok HP, Wust P, Stauffer PR, Bardati F, van Rhoon GC, Crezee J, Current state of the art of regional hyperthermia treatment planning: a review. RADIAT ONCOL 2015;10 (1):196 [PubMed]
Kosterev VV, Kramer-Ageev EA, Mazokhin VN, van Rhoon GC, Crezee J, Development of a novel method to enhance the therapeutic effect on tumours by simultaneous action of radiation and heating. INT J HYPERTHER 2015;31 (4):443-452 [PubMed]
Oei AL, van Leeuwen CM, ten Cate R, Rodermond HM, Buist MR, Stalpers LJA, Crezee J, Kok HP, Medema JP, Franken NAP, Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis. CANCER RES 2015;75 (23):5120-5129 [PubMed]
Oei AL, Vriend LEM, Crezee J, Franken NAP, Krawczyk PM, Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. RADIAT ONCOL 2015;10:165 [PubMed]
Oldenborg S, Griesdoorn V, van Os R, Kusumanto YH, Oei BS, Venselaar JL, Zum Vörde Sive Vörding PJ, Heymans MW, Kolff MW , Rasch CRN, Crezee H, van Tienhoven G, Reirradiation and hyperthermia for irresectable locoregional recurrent breast cancer in previously irradiated area: Size matters. RADIOTHER ONCOL 2015;117 (2):223-228 [PubMed]
Depla AL, Scharloo-Karels CH, de Jong MAA, Oldenborg S, Kolff MW , Oei SB, van Coevorden F, van Rhoon GC, Baartman EA, Scholten RJ, Crezee J, van Tienhoven G, Treatment and prognostic factors of radiation-associated angiosarcoma (RAAS) after primary breast cancer: A systematic review. EUR J CANCER 2014;50 (10):1779-1788 [PubMed]
Kok HP, Ciampa S, de Kroon-Oldenhof R, Steggerda-Carvalho EJ, van Stam G, Zum Vörde Sive Vörding PJ, Stalpers LJA, Geijsen ED, Bardati F, Bel A, Crezee J, Toward online adaptive hyperthermia treatment planning: correlation between measured and simulated specific absorption rate changes caused by phase steering in patients. INT J RADIAT ONCOL 2014;90 (2):438-445 [PubMed]
Kok HP, Crezee J, Franken NAP, Stalpers LJA, Barendsen GW, Bel A, Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions. INT J RADIAT ONCOL 2014;88 (3):739-745 [PubMed]
Sloothaak DAM, Gardenbroek TJ, Crezee J, Bemelman WA, Punt CJA, Buskens CJ, Tanis PJ, Feasibility of adjuvant laparoscopic hyperthermic intraperitoneal chemotherapy in a short stay setting in patients with colorectal cancer at high risk of peritoneal carcinomatosis. EJSO-EUR J SURG ONC 2014;40 (11):1453-1458 [PubMed]
Balidemaj E , Trinks J, Berg van den CAT, Nederveen A, van Lier AL, Stalpers LJA, Crezee H, Remis RF. CSI-EPT: A novelcontrast source approach to MRI based electric propertiees tomography and patient-specific SAR in: Anonymous A, editor. ICEAA `13: 2013 International Conference on Electromagnetics in Advanced Applications. S.l.: s.n.; 2013., p. 668-671
Cordeiro ER, Geijsen DE, Zum Vörde Sive Vörding PJ, Schooneveldt G, Sijbrands J, Hulshof MC, de la Rosette J, de Reijke TM, Crezee H, Novel multisensor probe for monitoring bladder temperature during locoregional chemohyperthermia for nonmuscle-invasive bladder cancer: technical feasibility study. J ENDOUROL 2013;27 (12):1504-1509 [PubMed]
de Greef M, Ipek O, Raaijmakers AJE, Crezee J, van den Berg CAT, Specific Absorption Rate Intersubject Variability in 7T Parallel Transmit MRI of the Head. MAGN RESON MED 2013;69 (5):1476-1485 [PubMed]
Franken NAP, Oei AL, Kok HP, Rodermond HM, Sminia P, Crezee J, Stalpers LJA, Barendsen GW, Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review). INT J ONCOL 2013;42 (5):1501-1515 [PubMed]
Kok HP, Gellermann J, van den Berg CAT, Stauffer PR, Hand JW, Crezee J, Thermal modelling using discrete vasculature for thermal therapy: A review. INT J HYPERTHER 2013;29 (4):336-345 [PubMed]
Kok HP, van den Berg CAT, Bel A, Crezee J, Fast thermal simulations and temperature optimization for hyperthermia treatment planning, including realistic 3D vessel networks. MED PHYS 2013;40 (10):103303 [PubMed]
Sauer R, Crezee H, Hulshof M, Issels R, Ott O, van Rhoon G, The letter of the Ludwig Boltzmann Institute is unnecessarily polarizing to the discussion on whether or not hypothermia is evidence based Reply. STRAHLENTHER ONKOL 2013;189 (1):84-86
Bruggmoser G, Bauchowitz S, Canters R, Crezee H, Ehmann M, Gellermann J, Lamprecht U, Lomax N, Messmer MB, Ott O, Abdel-Rahman S, Schmidt M, Sauer R, Thomsen A, Wessalowski R, van Rhoon G, Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia. STRAHLENTHER ONKOL 2012;188 (2):198-211 [PubMed]
de Greef M. Loco-regional hyperthermia treatment planning. Optimisation under uncertainty. s.l.: s.n.; 2012. 187p. ISBN 9789088913747 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Koning CCE; copromotor(s): Crezee J)
Sauer R, Creeze H, Hulshof M, Issels R, Ott O, Concerning the final report "Hyperthermia: a systematic review" of the Ludwig Boltzmann Institute for Health Technology Assessment, Vienna, March 2010. STRAHLENTHER ONKOL 2012;188 (3):209-213 [PubMed]
Stippel G, van Rooijen DC, Crezee J, Bel A, Automatic delineation of body contours on cone-beam CT images using a delineation booster. PHYS MED BIOL 2012;57 (13):N225-N236 [PubMed]
van Rooijen DC, van Wieringen N, Stippel G, Crezee J, Koning CCE, Bel A, Dose-Guided Radiotherapy: Potential Benefit of Online Dose Recalculation for Stereotactic Lung Irradiation in Patients With Non-Small-Cell Lung Cancer. INT J RADIAT ONCOL 2012;83 (4):E557-E562 [PubMed]
Bruggmoser G, Bauchowitz S, Canters R, Crezee H, Ehmann M, Gellermann J, Lamprecht U, Lomax N, Messmer MB, Ott O, Abdel-Rahman S, Sauer R, Schmidt M, Thomsen A, Wessalowski R, van Rhoon G, Quality assurance for clinical studies in regional deep hyperthermia. STRAHLENTHER ONKOL 2011;187 (10):605-610 [PubMed]
de Greef M, Kok HP, Bel A, Crezee J, 3D versus 2D steering in patient anatomies: A comparison using hyperthermia treatment planning. INT J HYPERTHER 2011;27 (1):74-85 [PubMed]
de Greef M, Kok HP, Correia D , Borsboom PP, Bel A, Crezee J, Uncertainty in hyperthermia treatment planning: the need for robust system design. PHYS MED BIOL 2011;56 (11):3233-3250 [PubMed]
Kok HP, de Greef M, Borsboom PP, Bel A, Crezee J, Improved power steering with double and triple ring waveguide systems: The impact of the operating frequency. INT J HYPERTHER 2011;27 (3):224-239 [PubMed]
de Greef M, Kok HP, Correia D , Bel A, Crezee J, Optimization in hyperthermia treatment planning: the impact of tissue perfusion uncertainty. MED PHYS 2010;37 (9):4540-4550 [PubMed]
Hulshof MCCM, van Haaren PMA, Zum Vörde Sive Vörding PJ, Krishnadath S, Marsman WA, van Berge Henegouwen MI, Geijsen ED, Crezee J, Radiotherapy combined with hyperthermia for primary malignant melanomas of the esophagus. DIS ESOPHAGUS 2010;23 (8):E42-E47 [PubMed]
Jansen MC, van Hillegersberg R, Schoots IG, Levi M, Beek JF, Crezee H, van Gulik TM, Cryoablation induces greater inflammatory and coagulative responses than radiofrequency ablation or laser induced thermotherapy in a rat liver model. SURGERY 2010;147 (5):686-695 [PubMed]
Kok HP, de Greef M, Wiersma J, Bel A, Crezee J, The impact of the waveguide aperture size of the 3D 70 MHz AMC-8 locoregional hyperthermia system on tumour coverage. PHYS MED BIOL 2010;55 (17):4899-4916 [PubMed]
Oldenborg S, van Os RM, van Rij CM, Crezee J, van de Kamer JB, Rutgers EJT, Geijsen ED, Zum Vörde Sive Vörding PJ, Koning CCE, van Tienhoven G, Elective re-irradiation and hyperthermia following resection of persistent locoregional recurrent breast cancer: A retrospective study. INT J HYPERTHER 2010;26 (2):136-144 [PubMed]
Petra Kok H, Correia D, de Greef M, van Stam G, Bel A, Crezee J, SAR deposition by curved CFMA-434 applicators for superficial hyperthermia: Measurements and simulations. INT J HYPERTHER 2010;26 (2):171-184 [PubMed]
Petra Kok H, de Greef M, van Wieringen N, Correia D, Hulshof MCCM, Zum Vörde Sive Vörding PJ, Sijbrands J, Bel A, Crezee J, Comparison of two different 70 MHz applicators for large extremity lesions: Simulation and application. INT J HYPERTHER 2010;26 (4):376-388 [PubMed]
Correia D, Kok HP, de Greef M, Bel A, van Wieringen N, Crezee J, Body conformal antennas for superficial hyperthermia: the impact of bending contact flexible microstrip applicators on their electromagnetic behavior. IEEE T BIO-MED ENG 2009;56 (12):2917-2926 [PubMed]
Crezee J, Barendsen GW, Westermann AM, Hulshof MCCM, Haveman J, Stalpers LJA, Geijsen ED, Franken NAP, QUANTIFICATION OF THE CONTRIBUTION OF HYPERTHERMIA TO RESULTS OF CERVICAL CANCER TRIALS: IN REGARD TO PLATANIOTIS AND DALE (INT J RADIAT ONCOL BIOL PHYS 2009;73:1538-1544). INT J RADIAT ONCOL 2009;75 (2):634 [PubMed]
Crezee J, van Haaren PMA, Westendorp H, de Greef M, Kok HP, Wiersma J, van Stam G, Sijbrands J, Zum Vörde Sive Vörding P, van Dijk JDP, Hulshof MCCM, Bel A, Improving locoregional hyperthermia delivery using the 3-D controlled AMC-8 phased array hyperthermia system: A preclinical study. INT J HYPERTHER 2009;25 (7):581-592 [PubMed]
de Greef M, Crezee J, van Eijk JC, Pool R, Bel A, Accelerated ray tracing for radiotherapy dose calculations on a GPU. MED PHYS 2009;36 (9):4095-4102 [PubMed]
Hulshof MCCM, van Haaren PMA, van Lanschot JJB, Richel DJ, Fockens P, Oldenborg S, Geijsen ED, van Berge Henegouwen MI, Crezee J, Preoperative chemoradiation combined with regional hyperthermia for patients with resectable esophageal cancer. INT J HYPERTHER 2009;25 (1):79-85 [PubMed]
Kok HP, de Greef M, Bel A, Crezee J, Acceleration of high resolution temperature based optimization for hyperthermia treatment planning using element grouping. MED PHYS 2009;36 (8):3795-3805 [PubMed]
Kok HP, de Greef M, Correia D, Zum Vorde Sive Vording PJ, van Stam G, Gelvich EA, Bel A, Crezee J, FDTD simulations to assess the performance of CFMA-434 applicators for superficial hyperthermia. INT J HYPERTHER 2009;25 (6):462-476 [PubMed]
van Wieringen N, Wiersma J, Zum Vörde Sive Vörding P, Oldenborg S, Gelvich EA, Mazokhin VN, van Dijk JDP, Crezee J, Characteristics and performance evaluation of the capacitive Contact Flexible Microstrip Applicator operating at 70 MHz for external hyperthermia. INT J HYPERTHER 2009;25 (7):542-553 [PubMed]
van Haaren PMA, Hulshof MCCM, Kok HP, Oldenborg S, Geijsen ED, van Lanschot JJB, Crezee J, Relation between body size and temperatures during locoregional hyperthermia of oesophageal cancer patients. INT J HYPERTHER 2008;24 (8):663-674 [PubMed]
Bergs JWJ, Franken NAP, Haveman J, Geijsen ED, Crezee J, van Bree C, Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application. INT J HYPERTHER 2007;23 (4):329-341 [PubMed]
Kok HP. Treatment planning for locoregional and intraluminal hyperthermia. s.l.: s.n.; 2007. 189p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Koning CCE; copromotor(s): Crezee J)
Kok HP, van den Berg CAT, van Haaren PMA, Crezee J, Artefacts in intracavitary temperature measurements during regional hyperthermia. PHYS MED BIOL 2007;52 (17):5157-5171 [PubMed]
Kok HP, van Haaren PMA, van de Kamer JB, Crezee J, Theoretical comparison of intraluminal heating techniques. INT J HYPERTHER 2007;23 (4):395-411 [PubMed]
van Haaren PMA, Kok HP, van den Berg CAT, Zum Vorde Sive Vording PJ, Oldenborg S, Stalpers LJA, Schilthuis MS, de Leeuw AAC, Crezee J, On verification of hyperthermia treatment planning for cervical carcinoma patients. INT J HYPERTHER 2007;23 (3):303-314 [PubMed]
Wiersma J, van Wieringen N, Crezee H, van Dijk JDP, Delineation of potential hot spots for hyperthermia treatment planning optimisation. INT J HYPERTHER 2007;23 (3):287-301 [PubMed]
Kok HP, van Haaren PMA, van de Kamer JB, Zum Vörde Sive Vörding PJ, Wiersma J, Hulshof MCCM, Geijsen ED, van Lanschot JJB, Crezee J, Prospective treatment planning to improve locoregional hyperthermia for oesophageal cancer. INT J HYPERTHER 2006;22 (5):375-389 [PubMed]
van Haaren PMA, Kok HP, Zum Vörde Sive Vörding PJ, van Dijk JDP, Hulshof MCCM, Fockens P, van Lanschot JJB, Crezee J, Reliability of temperature and SAR measurements at oesophageal tumour locations. INT J HYPERTHER 2006;22 (7):545-561 [PubMed]
Westerterp M, Omloo JMT, Sloof GW, Hulshof MCCM, Hoekstra OS, Crezee H, Boellaard R, Vervenne WL, ten Kate FJW, van Lanschot JJB, Monitoring of response to pre-operative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET. J CLIN GASTROENTEROL 2006;40 (Suppl. 4):S180-ev
Westerterp M, Omloo JMT, Sloof GW, Hulshof MCCM, Hoekstra OS, Crezee H, Boellaard R, Vervenne WL, ten Kate FJW, van Lanschot JJB, Monitoring of response to pre-operative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET. INT J HYPERTHER 2006;22 (2):149-160 [PubMed]
Kok HP, van Haaren PMA, van de Kamer JB, Wiersma J, van Dijk JDP, Crezee J, High-resolution temperature-based optimization for hyperthermia treatment planning. PHYS MED BIOL 2005;50 (13):3127-3141 [PubMed]
Kok HP, van Haaren PMA, van Dijk JDP, Crezee J, On estimation of the temperature maximum in intraluminal or intracavitary hyperthermia. INT J HYPERTHER 2005;21 (4):287-304 [PubMed]
Albregts M, Hulshof MCCM, Zum Vörde Sive Vörding PJ, van Lanschot JJB, Richel DJ, Crezee H, Fockens P, van Dijk JDP, González González D, A feasibility study in oesophageal carcinoma using deep loco-regional hyperthermia combined with concurrent chemotherapy followed by surgery. INT J HYPERTHER 2004;20 (6):647-659 [PubMed]
Hulshof MCCM, Raaymakers BW, Lagendijk JJW, Koot RW, Crezee H, Stalpers LJA, González González D, A feasibility study of interstitial hyperthermia plus external beam radiotherapy in glioblastoma multiforme using the Multi Electrode Current Source (MECS) system. INT J HYPERTHER 2004;20 (5):451-463 [PubMed]
van Vulpen M, Raaymakers BW, Lagendijk JJW, Crezee J, de Leeuw AAC, van Moorselaar JRA, Ligtvoet CM, Battermann JJ, Three-dimensional controlled interstitial hyperthermia combined with radiotherapy for locally advanced prostate carcinoma--a feasibility study. INT J RADIAT ONCOL 2002;53 (1):116-126 [PubMed]
Kaatee RS, Nowak PC, van der Zee J, de Bree J, Kanis BP, Crezee H, Levendag PC, Visser AG, Clinical thermometry, using the 27 MHz multi-electrode current-source interstitial hyperthermia system in brain tumours. RADIOTHER ONCOL 2001;59 (2):227-231 [PubMed]
Raaymakers BW, van Vulpen M, Lagendijk JJ, de Leeuw AA, Crezee J, Battermann JJ, Determination and validation of the actual 3D temperature distribution during interstitial hyperthermia of prostate carcinoma. PHYS MED BIOL 2001;46 (12):3115-3131 [PubMed]
Raaymakers BW, Crezee J, Lagendijk JJ, Modelling individual temperature profiles from an isolated perfused bovine tongue. PHYS MED BIOL 2000;45 (3):765-780 [PubMed]
Crezee J, Kaatee RS, van der Koijk JF, Lagendijk JJ, Spatial steering with quadruple electrodes in 27 MHz capacitively coupled interstitial hyperthermia. INT J HYPERTHER 1999;15 (2):145-156 [PubMed]
Kaatee RS, Crezee H, Visser AG, Temperature measurement errors with thermocouples inside 27 MHz current source interstitial hyperthermia applicators. PHYS MED BIOL 1999;44 (6):1499-1511 [PubMed]
Raaymakers BW, Crezee J, Lagendijk JJ, Comparison of temperature distributions in interstitial hyperthermia: experiments in bovine tongues versus generic simulations. PHYS MED BIOL 1998;43 (5):1199-1214 [PubMed]
van der Koijk JF, Crezee J, Lagendijk JJ, Thermal properties of capacitively coupled electrodes in interstitial hyperthermia. PHYS MED BIOL 1998;43 (1):139-153 [PubMed]
Crezee J, van der Koijk JF, Kaatee RS, Lagendijk JJ, Implications of using thermocouple thermometry in 27 MHz capacitively coupled interstitial hyperthermia. PHYS MED BIOL 1997;42 (4):637-650 [PubMed]
Kaatee RS, Crezee H, Kanis BP, Lagendijk JJ, Levendag PC, Visser AG, Spatial temperature control with a 27 MHz current source interstitial hyperthermia system. INT J RADIAT ONCOL 1997;37 (1):189-197 [PubMed]
Kaatee RS, Crezee J, Kanis AP, Lagendijk JJ, Levendag PC, Visser AG, Design of applicators for a 27 MHz multielectrode current source interstitial hyperthermia system; impedance matching and effective power. PHYS MED BIOL 1997;42 (6):1087-1108 [PubMed]
van der Koijk JF, de Bree J, Crezee J, Lagendijk JJ, Numerical analysis of capacitively coupled electrodes for interstitial hyperthermia. INT J HYPERTHER 1997;13 (6):607-619 [PubMed]
van der Koijk JF, Lagendijk JJ, Crezee J, de Bree J, Kotte AN, van Leeuwen GM, Battermann JJ, The influence of vasculature on temperature distributions in MECS interstitial hyperthermia: importance of longitudinal control. INT J HYPERTHER 1997;13 (4):365-385 [PubMed]
van Leeuwen GM, Kotte AN, Crezee J, Lagendijk JJ, Tests of the geometrical description of blood vessels in a thermal model using counter-current geometries. PHYS MED BIOL 1997;42 (8):1515-1532 [PubMed]
van Leeuwen GM, Kotte AN, de Bree J, van der Koijk JF, Crezee J, Lagendijk JJ, Accuracy of geometrical modelling of heat transfer from tissue to blood vessels. PHYS MED BIOL 1997;42 (7):1451-1460 [PubMed]
Kotte A, van Leeuwen G, de Bree J, van der Koijk J, Crezee H, Lagendijk J, A description of discrete vessel segments in thermal modelling of tissues. PHYS MED BIOL 1996;41 (5):865-884 [PubMed]
van der Koijk JF, Crezee J, van Leeuwen GM, Battermann JJ, Lagendijk JJ, Dose uniformity in MECS interstitial hyperthermia: the impact of longitudinal control in model anatomies. PHYS MED BIOL 1996;41 (3):429-444 [PubMed]
Crezee J, Mooibroek J, Lagendijk JJ, van Leeuwen GM, The theoretical and experimental evaluation of the heat balance in perfused tissue. PHYS MED BIOL 1994;39 (5):813-832 [PubMed]
Lagendijk JJ, Crezee J, Hand JW, Dose uniformity in scanned focused ultrasound hyperthermia. INT J HYPERTHER 1994;10 (6):775-784 [PubMed]
de Leeuw AA, Crezee J, Lagendijk JJ, Temperature and SAR measurements in deep-body hyperthermia with thermocouple thermometry. INT J HYPERTHER 1993;9 (5):685-697 [PubMed]
Crezee J, Lagendijk JJ, Temperature uniformity during hyperthermia: the impact of large vessels. PHYS MED BIOL 1992;37 (6):1321-1337 [PubMed]
Bos CK, Crezee J, Mooibroek J, Lagendijk JJ, A perfusion technique for tongues to be used in bioheat transfer studies. PHYS MED BIOL 1991;36 (6):843-846 [PubMed]
Crezee J, Mooibroek J, Bos CK, Lagendijk JJ, Interstitial heating: experiments in artificially perfused bovine tongues. PHYS MED BIOL 1991;36 (6):823-833 [PubMed]
Crezee J, Lagendijk JJ, Experimental verification of bioheat transfer theories: measurement of temperature profiles around large artificial vessels in perfused tissue. PHYS MED BIOL 1990;35 (7):905-923 [PubMed]
Metselaar JW, Goovaerts HG, Crezee J, Generation of a fast and homogeneous temperature step. J BIOCHEM BIOPH METH 1987;14 (4):233-242 [PubMed]
Metselaar JW, Crezee J, Goovaerts HG, Generation of a rapid step in the temperature of a papillary muscle. MED BIOL ENG COMPUT 1986;24 (5):475-481 [PubMed]
Key publications

Geijsen ED, de Reijke TM, Koning CC, Zum Vörde Sive Vörding PJ, de la Rosette JJ, Rasch CR, van Os RM, Crezee J, Combining Mitomycin C and Regional 70 MHz Hyperthermia in Patients with Nonmuscle Invasive Bladder Cancer: A Pilot Study. J UROLOGY 2015;194 (5):1202-1208 [PubMed]
Oei AL, van Leeuwen CM, ten Cate R, Rodermond HM, Buist MR, Stalpers LJA, Crezee J, Kok HP, Medema JP, Franken NAP, Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis. CANCER RES 2015;75 (23):5120-5129 [PubMed]
Kok HP, Ciampa S, de Kroon-Oldenhof R, Steggerda-Carvalho EJ, van Stam G, Zum Vörde Sive Vörding PJ, Stalpers LJA, Geijsen ED, Bardati F, Bel A, Crezee J, Toward online adaptive hyperthermia treatment planning: correlation between measured and simulated specific absorption rate changes caused by phase steering in patients. INT J RADIAT ONCOL 2014;90 (2):438-445 [PubMed]
Kok HP, van den Berg CAT, Bel A, Crezee J, Fast thermal simulations and temperature optimization for hyperthermia treatment planning, including realistic 3D vessel networks. MED PHYS 2013;40 (10):103303 [PubMed]
Crezee H, van Leeuwen CM, Oei AL, Stalpers LJA, Bel A, Franken NA, Kok HP, Thermoradiotherapy planning: Integration in routine clinical practice. INT J HYPERTHER 2016;32 (1):41-49 [PubMed]


All Publications

Curriculum Vitae

1986: M.Sc. in experimental physics with experimental work on Medical Physics (Free University, Amsterdam).
1988-1992: Project on the representation of blood flow in thermal models used in hyperthermia treatment planning, and experimental evaluation of these models (UMC Utrecht).
1993: PhD thesis ‘verification of thermal models’ (University of Utrecht).
1992-1997: Development of a system for clinical application of interstitial hyperthermia with spatial power control for improved temperature uniformity in the target region (UMC Utrecht). Supervision of four PhD students working on projects related to the development of this hyperthermia device and on development of a clinical discrete vessel (DIVA) thermal model.
1997-1999: Clinical application of interstitial hyperthermia for brain and prostate implants (UMC Utrecht). Supervision of PhD student working on validation of thermal models.
2000-present: Hyperthermia research at the Department of Radiotherapy of the Academic Medical Center in Amsterdam, initially emphasis on system design and treatment planning. First project involved development of a new 8 antenna deep hyperthermia system for pelvic tumors.
2008-present: Principal Investigator (PI) for hyperthermia research at the Department of Radiotherapy of AMC and responsible for multidisciplinary hyperthermia research on hyperthermia system design and treatment planning, and commercialisation of resulting products developed at AMC. Treatment planning focuses on challenging locations (e.g. bladder) and on biological modelling and realtime adaptive treatment planning. Also involved in clinical trials on hyperthermia in breast cancer and bladder cancer and in basic research on working mechanisms of hyperthermia, also for inclusion in biological treatment planning. Supervision of more than10 PhD students working on different projects.

Hans Crezee is project leader for several research projects granted by the Dutch Cancer Society Koningin Wilhelmina Fonds (KWF):
- Development of a dual modality hyperthermia technique for esophageal cancer (J Crezee, N van Wieringen, G van Tienhoven, AMC 2002-2622: € 423363.-).
- Optimisation of regional hyperthermia delivery using hyperthermia planning (J Crezee, MCCM Hulshof, JB van de Kamer, UVA 2006-3484: € 461914.-).
- Improved temperature reconstruction technique based on treatment planning to be used during superficial hyperthermia (J Crezee, N van Wieringen, G van Tienhoven, UVA 2007-3841: € 262000.-).
- Improved treatment delivery using treatment planning and MRI data (J Crezee, AJ Nederveen, LJA Stalpers, UVA 2010-4660: € 319600.-).
- Active hot spot suppression to improve thermal dose and clinical outcome of locoregional hyperthermia treatments (J Crezee, HP Kok, LJA Stalpers, UVA 2012-5393: € 339300.-).
- Improved bladder temperature monitoring during hyperthermia treatments (J Crezee, MCCM Hulshof, TM de Reijke, UVA 2012-5539: € 417000.-).
- MRI based hyperthermia treatment planning for improved hyperthermia delivery in cervical cancer patients (J Crezee, ALHMW van Lier, LJA Stalpers, UVA 2014-7197: € 572500.-).
- Irreversible electroporation for locally advanced pancreatic cancer; optimization of clinical treatment by advanced treatment planning (MGH Besselink, J Crezee, TM van Gulik, UVA 2014-7244: € 523100.-).
- Hyperthermia induced synthetic lethality combined with PARP1 inhibition to sensitize radiotherapy and CDDP treatment of Cervical cancer (NAP Franken, LJA Stalpers, J Crezee, UVA 2015-7820: € 485600.-).
- Development of patient specific treatment planning to enhance and optimize clinical effectiveness of hyperthermic intraperitoneal chemotherapy in colorectal cancer patients (J Crezee, NAP Franken, HP Kok, PJ Tanis project UVA 2017-10595: € 563765.-).
- Clinical evaluation of the benefit of planning based steering to improve effectiveness of hyperthermia in cervical cancer patients (HP Kok, J Crezee, LJA Stalpers project UVA 2017-10873: € 326486.-)

Other grants:
- Medium investment grant NWO-ZonMw “A dedicated high resolution small animal hyperthermia device to support translation of novel cancer therapies from lab to bedside” (project 40-00506-98-16015 (2016), principal applicant J. Crezee, co-applicant N.A.P. Franken: € 443250.-).
- Children cancer fund KiKa project 253 (2016) “Radiotherapy and hyperthermia for children: from concept to breakthrough?”. Project leaders A. Bel, J. Crezee, C.R.N. Rasch, H.J. Merks: € 78762.-.

Total grant money for larger grants: € 5216640.-


Other activities:
- member “Treatment planning and modelling in hyperthermia” task group of the European Society for Hyperthermic Oncology in cooperation with a COMAC BME Concerted Action within the 4th Medical and Health Research Programme of the European Commission (1990-1992)
- Organisation of 2006 annual meeting Hyperthermia Working Group of the Dutch Cancer Society (Amsterdam, 21 April 2006).
- Co-Promotor for Petra Kok (PhD thesis University of Amsterdam 2007).
- Member PhD committee Judith Bergs (University of Amsterdam 2007).
- Member NWO/STW jury “vernieuwingsimpuls” VIDI for 2008.
- Secretary Hyperthermia Working Group of the Dutch Cancer Society (2008-present).
- Organisation of 2009 annual meeting Hyperthermia Working Group of the Dutch Cancer Society (Amsterdam, 8 May 2009).
- Member Quality Assurance committee of the Interdisciplinary Working Group Hyperthermia (IAH) of the German Cancer Society “Atzelsberg circle” (2010-present).
- Collaborator ISTC project 3996 “simultaneous action of radiation and heating” (2010-present)
- Member PhD committee Hana Dobsicek-Trefna (Chalmers University Göteborg, June 2010).
- Secretary Maurits and Anna de Kock Foundation (2011-present)
- Board member European Society for Hyperthermic Oncology ESHO (2011-2014)
- Member technical committee European Society for Hyperthermic Oncology ESHO (2011-present)
- Editorial Board ISRN Biomathematics (2011-present)
- Editorial Board Journal of Cancer Research and Therapeutics-JCRT (2011-present)
- Host for professor Rolf Issels (LMU, Munich), Spinoza chair at the University of Amsterdam 8-10 November 2011
- Organisation of 2011 annual meeting Hyperthermia Working Group of the Dutch Cancer Society (Amsterdam, 11 November 2011).
- Co-Promotor for Martijn de Greef (PhD thesis University of Amsterdam 9 February 2012).
- member International Scientific Committee of the 11th International Congress of Hyperthermic Oncology (Kyoto 28-31 August 2012).
- Member PhD committee Richard Canters (Erasmus University Rotterdam 2013).
- Editorial Board International Journal of Hyperthermia (2013-present)
- Guest researcher at the Department of signals and systems at Chalmers University, Göteborg, September – December 2013, August – December 2014.
- Teacher at ESHO (European Society for Hyperthermic Oncology) school, Huntsham Court, Devon, 3-6 February 2014
- Organisation of 2014 annual meeting Hyperthermia Working Group of the Dutch Cancer Society (Amsterdam, 11 December 2014).
- Organisation hyperthermia workshop during the 8th International Symposium on “Focal Therapy and Imaging in Prostate and Kidney Cancer” (Noordwijk, Netherlands, 21-23 June 2015).
- Guest Editor for special issue of Int. J Hyperthermia on hyperthermia in bladder cancer (together with Brant Inman).
- Co-Promotor for Edmond Balidemaj (PhD thesis University of Amsterdam 25 May 2016).
- Member PhD committee Tom Arends (Radboud University Nijmegen 17 June 2016).
- Member PhD committee Marianne Linthorst (Erasmus University Rotterdam 20 December 2016).
- Host for professor Mark W. Dewhirst (Duke, NC), Spinoza chair at the University of Amsterdam 21-24 March 2017
- Section Editor International Journal of Hyperthermia (2017-present)

Honors and awards:
- Recipient of 12,500.- donation awarded for KWF project UVA 2006-3484 (2007).
- Dr. B.B. Singh Award, 6th Biennial meeting of Indian Association of Hyperthermic Oncology and Medicine, Bangalore 2010.
- Annual Award of Merit at annual meeting of the Society for Cancer Research and Communication, Mumbai February 2, 2012.
- Sugahara Oration 8th Biennial meeting of Indian Association of Hyperthermic Oncology and Medicine, Bharatpur, Nepal 21-22 Feb 2014
- Life Time Achievement Award of Indian Association of Hyperthermic Oncology and Medicine, Ahmedabad, February 18, 2017

Peer reviewed papers
1. Kok HP, Korshuize-van Straten L, Bakker A, de Kroon- Oldenhof R, Geijsen ED, Stalpers LJA, Crezee J. On-line adaptive hyperthermia treatment planning during locoregional heating to suppress treatment limiting hot spots. Int J Radiat Oncol Biol Phys. 2017;99(4):1039-47
2. Crezee J, van Tienhoven G, Kolff MW, Sijbrands J, van Stam G, Oldenborg S, Geijsen ED, Hulshof MCCM, Kok HP. Development of a 70 MHz unit for hyperthermia treatment of deep-seated breast tumors. International Journal of Microwave and Wireless Technologies 2017;9(6):1317-24
3. Oei AL, Ahire VR, van Leeuwen CM, Ten Cate R, Stalpers LJA, Crezee J, Kok HP, Franken NAP. Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i. Int J Hyperthermia. 2017 May 19 (early online)
4. van Stam G, Kok HP, Hulshof MCCM, Kolff MW, van Tienhoven G, Sijbrands J, Bakker A, Zum Vörde Sive Vörding PJ, Oldenborg S, de Greef M, Rasch CRN, Crezee H. A flexible 70 MHz phase-controlled double waveguide system for hyperthermia treatment of superficial tumours with deep infiltration. Int J Hyperthermia. 2017;33(7):796-809
5. van Leeuwen CM, Oei AL, ten Cate R, Franken NAP, Bel A, Stalpers LJA, Crezee J, Kok HP. Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation. Int J Hyperthermia. 2017 Apr 18 (early online)
6. Klaver CEL, Stam R, Sloothaak DAM, Crezee J, Bemelman WA, Punt CJA, Tanis PJ. Colorectal cancer at high risk of peritoneal metastases: long term outcomes of a pilot study on adjuvant laparoscopic HIPEC and future perspectives. Oncotarget. 2017 Apr 17. (early online)
7. van Leeuwen CM, Oei AL, Chin KWTK, Crezee J, Bel A, Westermann AM, Buist MR, Franken NAP, Stalpers LJA, Kok HP. A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer. Radiat Oncol. 2017;12(1):75
8. Vogel JA, van Veldhuisen E, Agnass P, Crezee J, Dijk F, Verheij J, van Gulik TM, Meijerink MR, Vroomen LG, van Lienden KP, Besselink MG. Correction: Time-Dependent Impact of Irreversible Electroporation on Pancreas, Liver, Blood Vessels and Nerves: A Systematic Review of Experimental Studies. PLoS One. 2017;12(3):e0174018
9. Oei AL, van Leeuwen CM, Rodermond H, ten Cate R, Westermann AM, Stalpers LJ, Crezee J, Kok HP, Krawzcyk PM, Kanaar R, Franken NA. Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumor cells with hyperthermia. Oncotarget. 2017;8(17):28116-28124.
10. Dobšíček Trefná H, Crezee J, Schmidt M, Marder D, Lamprecht U, Ehmann M, Hartmann J, Gellermann J, van Holthe JM, Lomax N, Abdel-Rahman S, Bert C, Bakker A, Hurwitz M, Diedrich CJ, Stauffer PR, van Rhoon GC. Atzelsberg Research Group quality assurance guidelines for the application of superficial hyperthermia clinical trials: II. Technical requirements for heating devices. Strahlentherapie und Onkologie 2017;193(5):351-366.
11. Kok HP, Kotte AN, Crezee J. Planning, optimization and evaluation of hyperthermia treatments. Int J Hyperthermia. 2017;33(6):593-607
12. Bakker A, Kolff MW, Holman R, van Leeuwen CM, Korshuize-van Straten L, Oldenhof-de Kroon R, Rasch CR, van Tienhoven G, Crezee J. Thermal skin damage during reirradiation and hyperthermia is time temperature dependent. Int J Rad Oncol Biol Phys. 2017;98(2):392-399.
13. Oei AL, Vriend LE, Krawczyk PM, Horsman MR, Franken NA, Crezee J. Targeting therapy-resistant cancer stem cells by hyperthermia. Int J Hyperthermia. 2017;33(4):419-426.
14. Trefna HD, Crezee H, Schmidt M, Marder D, Lamprecht U, Ehmann M, Hartmann J, Nadobny J, Gellermann J, van Holthe N, Ghadjar P, Lomax N, Abdel-Rahman S, Bert C, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, van Rhoon GC. Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirements. Int J Hyperthermia. 2017;33(4):471-482.
15. Kok HP, Crezee J. A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia. Int J Hyperthermia. 2017;33(4):378-386.
16. van Leeuwen CM, Crezee J, Oei AL, Franken NA, Stalpers LJ, Bel A, Kok HP. 3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments. Int J Hyperthermia. 2017;33(2):160-9.
17. Balidemaj E, Van den Berg CA, van Lier AL, Nederveen AJ, Stalpers LJ, Crezee H, Remis RF. B1-based SAR reconstruction using contrast source inversion-electric properties tomography (CSI-EPT). Med Biol Eng Comput. 2017;55(2):225-33.
18. Vogel JA, van Veldhuisen E, Agnass P, Crezee J, Dijk F, Verheij J, van Gulik TM, Meijerink MR, Vroomen LG, van Lienden KP, Besselink MG. Time-Dependent Impact of Irreversible Electroporation on Pancreas, Liver, Blood Vessels and Nerves: A Systematic Review of Experimental Studies. PLoS One. 2016;11(11):e0166987.
19. Crezee J, Van Tienhoven G, Kolff MW, Sijbrands J, Van Stam G, Oldenborg S, Geijsen ED, Hulshof MCCM, Kok HP. Development of a 70 MHz unit for hyperthermia treatment of deep seated breast tumors. Proceedings of the 46th European Microwave Conference 2016; p906-909. DOI: 10.1109/EuMC.2016.7824491
20. Kok HP, Bakker A, Kolff MW, Van Tienhoven G, Hulshof MCCM, Van Stam G, Crezee J. 70 MHz Double Waveguide Set-up for Hyperthermia of Deep Superficial Tumors. Proceedings of the 46th European Microwave Conference 2016; p1219-1222. DOI:10.1109/EuMC.2016.7824569
21. Franken NA, Kok HP, Crezee J, Barendsen GW. Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation. Int J Radiat Biol. 2016;92(9):521-6.
22. Schooneveldt G, Kok HP, Balidemaj E, Geijsen ED, van Ommen F, Sijbrands J, Bakker A, de la Rosette JJ, Hulshof MC, de Reijke TM, Crezee J. Improving hyperthermia treatment planning for the pelvis by accurate fluid modelling. Med Phys. 2016;43(10):5442-52.
23. Oei AL, Vriend LE, van Leeuwen CM, Rodermond HM, Ten Cate R, Westermann AM, Stalpers LJ, Crezee J, Kanaar R, Kok HP, Krawczyk PM, Franken NA. Sensitizing thermochemotherapy with a PARP1-inhibitor. Oncotarget. 2016;19(10):11422.
24. Balidemaj E, Kok HP, Schooneveldt G, van Lier AL, Remis RF, Stalpers LJ, Westerveld GH, Nederveen AJ, Van den Berg CA, Crezee J. Hyperthermia Treatment Planning for cervical cancer patients based on electric conductivity tissue properties acquired in vivo with EPT at 3T MRI. Int J Hyperthermia. 2016;32(5):558-68.
25. Schooneveldt G, Kok HP, Bakker A, Geijsen ED, de Reijke TM, Crezee J. SU-F-J-05: The Effect of Air Pockets in the Urinary Bladder During Bladder Hyperthermia Treatment. Med Phys. 2016;43(6):3406.
26. Crezee H, Inman B. The use of hyperthermia in the treatment of bladder cancer. Int J Hyperthermia. 2016;32(4):349-50.
27. Liem E, Crezee J, de la Rosette JJ, de Reijke TM. Chemohyperthermia in non-muscle invasive bladder cancer: an overview of the literature and recommendations. Int J Hyperthermia. 2016;32(4):363-73.
28. Schooneveldt G, Bakker A, Balidemaj E, Chopra R, Crezee J, Geijsen ED, Hartmann J, Hulshof MC, Kok HP, Paulides MM, Sousa-Escandon A, Stauffer PR, Maccarini PF. Thermal dosimetry for bladder cancer hyperthermia treatment. An overview. Int J Hyperthermia. 2016;32(4):417-33.
29. Oldenborg S, Valk C, van Os R, Oei B, Venselaar J, Zum Vorde Sive Vording P, van Randen A, Crezee H, van Tienhoven G, Rasch C. Rib fractures after reirradiation plus hyperthermia for recurrent breast cancer. Strahlenther Onkol. 2016;192(4):240-7.
30. Crezee H, van Leeuwen CM, Oei AL, Stalpers LJ, Bel A, Franken NA, Kok HP. Thermoradiotherapy planning: integration in routine clinical practice. Int J Hyperthermia. 2016;32(1):41-9.
31. Balidemaj E, de Boer P, van Lier AL, Remis RF, Stalpers LJ, Westerveld GH, Nederveen AJ, Van den Berg CA, Crezee H. In vivo electric conductivity of cervical cancer patients based on B1+ maps at 3T MRI. Phys Med Biol. 2016;61(4):1596-607.
32. Crezee J, van Leeuwen CM, Oei AL, van Heerden LE, Bel A, Stalpers LJ, Ghadjar P, Franken NA, Kok HP. Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer. Radiat Oncol. 2016;11:14.
33. Oei AL, van Leeuwen CM, ten Cate R, Rodermond H, Buist MR, Stalpers LJ, Crezee J, Kok HP, Medema JP, Franken NA. Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis. Cancer Res. 2015;75(23):5120-9.
34. Oldenborg S, Griesdoorn V, van Os R, Kusumanto YH, Oei BS, Venselaar JL, Zum Vorde Sive Vording PJ, Heymans MW, Kolff MW, Rasch CR, Crezee H, van Tienhoven G. Reirradiation and hyperthermia for irresectable locoregional recurrent breast cancer in previously irradiated area: Size matters. Radiother Oncol. 2015;117(2):223-8.
35. Kok HP, Wust P, Stauffer PR, Bardati F, van Rhoon GC, Crezee J. Current state of the art of regional hyperthermia treatment planning: a review. Radiat Oncol. 2015;10:196.
36. Oei AL, Vriend LE, Crezee J, Franken NA, Krawczyk PM. Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. Radiat Oncol. 2015;10:165.
37. Kok HP, Van Stam G, Bel A, Crezee J. A Mixed Frequency Approach to Optimize Locoregional RF Hyperthermia. Proceedings of the 45th European Microwave Conference 2016; p773-776. DOI: 10.1109/EuMC.2015.7345878.
38. Crezee J, Harms HJ, Boluijt HJ, Sijbrands J, Hulshof MCCM, Kok HP. Development of a 27.12 MHz CC-LCF intraluminal applicator for hyperthermia of the oesophagus. Proceedings of the 45th European Microwave Conference 2016; p769-772. DOI: 10.1109/EuMC.2015.7345877
39. Geijsen ED, de Reijke TM, Koning CC, Zum Vorde Sive Vording PJ, de la Rosette JJ, Rasch CR, van Os R, Crezee J. Combining Mitomycin C and regional 70 MHz hyperthermia in patients with non-muscle invasive bladder cancer: a pilot study. J Urol. 2015;194(5):1202-8.
40. Datta NR, Gomez Ordonez S, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S. Local hyperthermia combined with radiotherapy and-/ or chemotherapy: Recent advances and promises for the future. Cancer Treat Rev. 2015;41(9):742-53.
41. Cihoric N, Tsikkinis A, van Rhoon G, Crezee H, Aebersold DM, Bodis S, Beck M, Nadobny J, Budach V, Wust P, Ghadjar P. Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry. Int J Hyperthermia. 2015;31(6):609-14.
42. Balidemaj E, Van den Berg CA, Trinks J, van Lier A, Nederveen AJ, Stalpers L, Crezee H, Remis RF. CSI-EPT: A Contrast Source Inversion Approach for Improved MRI-Based Electric Properties Tomography. IEEE Trans Med Imaging. 2015;34(9):1788-96.
43. Kosterev VV, Kramer-Ageev EA, Mazokhin VN, van Rhoon GC, Crezee J. Development of a novel method to enhance the therapeutic effect on tumours by simultaneous action of radiation and heating. Int J Hyperthermia. 2015;31(4):443-52.
44. Balidemaj E, van Lier AL, Crezee H, Nederveen AJ, Stalpers LJ, Van den Berg CA. Feasibility of Electric Property Tomography of pelvic tumors at 3T. Magn Reson Imaging. 2015;73(4):1505-13.
45. Sloothaak DA, Gardenbroek TJ, Crezee J, Bemelman WA, Punt CJ, Buskens CJ, Tanis PJ. Feasibility of adjuvant laparoscopic hyperthermic intraperitoneal chemotherapy in a short stay setting in patients with colorectal cancer at high risk of peritoneal carcinomatosis. Eur J Surg Oncol. 2014;40(11):1453-8.
46. Kok HP, Ciampa S, de Kroon-Oldenhof R, Steggerda-Carvalho EJ, van Stam G, Zum Vorde Sive Vording PJ, Stalpers LJ, Geijsen ED, Bardati F, Bel A, Crezee J. Towards on-line adaptive hyperthermia treatment planning: correlation between measured and simulated SAR changes caused by phase steering in patients. Int J Radiat Oncol Biol Phys. 2014;90(2):438-45.
47. Depla AL, Scharloo-Karels CH, de Jong MA, Oldenborg S, Kolff MW, Oei SB, van Coevorden F, van Rhoon GC, Baartman EA, Scholten RJ, Crezee J, van Tienhoven G. Treatment and prognostic factors of radiation-associated angiosarcoma (RAAS) after primary breast cancer: A systematic review. Eur J Cancer. 2014;50(10):1779-88.
48. Kok HP, Crezee J, Franken NA, Stalpers LJ, Barendsen GW, Bel A. Quantifying the Combined Effect of Radiation Therapy and Hyperthermia in Terms of Equivalent Dose Distributions. Int J Radiat Oncol Biol Phys. 2014;88(3):739-45.
49. G. Schooneveldt, H.P. Kok, E.D. Geijsen, F. van Ommen, A. Bakker, M.A. Westendarp Zanartu, J.J.M.C.H de la Rosette, M.C.C.M. Hulshof, T.M. de Reijke, J. Crezee, “Improved temperature monitoring and treatment planning for loco-regional hyperthermia treatments of Non-Muscle Invasive Bladder Cancer (NMIBC)”, in: Jaffray DA, ed. World Congress on Medical Physics and Biomedical Engineering, June 7–12, 2015 (2015, Toronto, Canada), 1691–1694, doi: 10.1007/978-3-319-19387-8_411.
50. Cordeiro Feijoo ER, Geijsen DE, Zum Vorde Sive Vording PJ, Schooneveldt G, Sijbrands J, Hulshof MC, de la Rosette J, de Reijke TM, Crezee H. Novel multi-sensor probe for monitoring bladder temperature during loco-regional chemo-hyperthermia for non-muscle invasive bladder cancer: technical feasibility study. J Endourol. 2013;27(12):1504-9.
51. Kok HP, Van den Berg CA, Bel A, Crezee J. Fast thermal simulations and temperature optimization for hyperthermia treatment planning, including realistic 3D vessel networks. Med Phys. 2013;40(10):103303-.
52. Kok HP, Gellermann J, Van den Berg CA, Stauffer PR, Hand JW, Crezee J. Thermal modelling using discrete vasculature for thermal therapy: a review. Int J Hyperthermia. 2013;29(4):336-45.
53. Franken NA, Oei AL, Kok HP, Rodermond HM, Sminia P, Crezee J, Stalpers LJ, Barendsen GW. Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review). Int J Oncol. 2013;42(5):1501-15.
54. de Greef M, Ipek O, Raaijmakers AJ, Crezee J, Van den Berg CA. Specific absorption rate intersubject variability in 7T parallel transmit MRI of the head. Magn Reson Med. 2013;69(5):1476-85.
55. Sauer R, Crezee H, Hulshof M, Issels R, Ott O, van Rhoon G. The letter of the Ludwig Boltzmann Institute is unnecessarily polarizing to the discussion on whether or not hypothermia is evidence based Reply. Strahlenther Onkol. 2013;189(1):84-6.
56. Bruggmoser G, Bauchowitz S, Canters R, Crezee H, Ehmann M, Gellermann J, Lamprecht U, Lomax N, Messmer MB, Ott O, Abdel-Rahman S, Schmidt M, Sauer R, Thrall DE, Wessalowski R, van Rhoon G, group Ar, Oncology ESfH. Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia: quality management in regional deep hyperthermia. Strahlenther Onkol. 2012;188, suppl 2:198-211.
57. Stippel G, van Rooijen DC, Crezee J, Bel A. Automatic delineation of body contours on cone-beam CT images using a delineation booster. Phys Med Biol. 2012;57(13):N225-N36.
58. van Rooijen DC, van Wieringen N, Stippel G, Crezee J, Koning CC, Bel A. Dose-Guided Radiotherapy: Potential Benefit of Online Dose Recalculation for Stereotactic Lung Irradiation in Patients with Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2012;83(4):e557-e62.
59. Sauer R, Creeze H, Hulshof M, Issels R, Ott O, Radiooncology. obotIWGfCHACotGCSatGSo. Concerning the final report "Hyperthermia: a systematic review" of the Ludwig Boltzmann Institute for Health Technology Assessment, Vienna, March 2010. Strahlenther Onkol. 2012;188(3):209-15.
60. Franken NA, Hovingh S, Rodermond H, Stalpers L, Barendsen GW, Crezee J. Radiosensitization with chemotherapeutic agents and hyperthermia: effects on linear-quadratic parameters of radiation cell survival curves. J Cancer Sci Ther. 2011;S5(002).
61. Bruggmoser G, Bauchowitz S, Canters R, Crezee H, Ehmann M, Gellerman J, Lamprecht U, Lomax N, Messmer MB, Ott O, Abdel-Rahman S, Sauer R, Schmidt M, Thomsen A, Wessalowski R, van Rhoon G. Quality Assurance for Clinical Studies in Regional Deep Hyperthermia. Strahlenther Onkol. 2011;187(10):605-10.
62. de Greef M, Kok HP, Correia D, Borsboom PP, Bel A, Crezee J. Uncertainty in hyperthermia treatment planning: the need for robust system design. Phys Med Biol. 2011;56(11):3233-50.
63. Kok HP, de Greef M, Borsboom PP, Bel A, Crezee J. Improved power steering with double and triple ring waveguide systems: The impact of the operating frequency. Int J Hyperthermia. 2011;27(3):224-39.
64. de Greef M, Kok HP, Bel A, Crezee J. 3D versus 2D steering in patient anatomies: a comparison using hyperthermia treatment planning. Int J Hyperthermia. 2011;27(1):74-85.
65. Hulshof MC, van Haaren PM, Zum Vorde Sive Vording PJ, Krishnadath S, Marsman WA, van Berge Henegouwen MI, Geijsen ED, Crezee J. Radiotherapy combined with hyperthermia for primary malignant melanomas of the esophagus. Dis Esophagus. 2010;23(8):E42-E7.
66. de Greef M, Kok HP, Correia D, Bel A, Crezee J. Optimization in hyperthermia treatment planning: The impact of tissue perfusion uncertainty. Med Phys. 2010;37:4540-50.
67. Kok HP, de Greef M, Wiersma J, Bel A, Crezee J. The impact of the waveguide aperture size of the 3D 70 MHz AMC-8 loco-regional hyperthermia system on tumour coverage. Phys Med Biol. 2010;55:4899-916.
68. Jansen MC, van Hillegersberg R, Schoots IG, Levi M, Beek JF, Crezee H, van Gulik TM. Cryoablation induces greater inflammatory and coagulative responses than radiofrequency ablation or laser induced thermotherapy in a rat liver model. Surgery. 2010;147(5):686-95.
69. Kok HP, de Greef M, van Wieringen N, Correia D, Hulshof MC, Zum Vorde Sive Vording PJ, Sijbrands J, Bel A, Crezee J. Comparison of two different 70 MHz applicators for large extremity lesions: simulation and application. Int J Hyperthermia. 2010;26(4):376-88.
70. Oldenborg S, van Os R, van Rij CM, Crezee J, van de Kamer JB, Rutgers EJ, Geijsen ED, Zum Vorde Sive Vording PJ, Koning CC, van Tienhoven G. Elective Reirradiation and Hyperthermia following Resection of Persistent Locoregional Recurrent Breast Cancer: a Retrospective Study. Int J Hyperthermia. 2010;26(2):136-44.
71. Kok HP, Correia D, de Greef M, van Stam G, Bel A, Crezee J. SAR deposition by curved CFMA-434 applicators for superficial hyperthermia: Measurements and simulations. Int J Hyperthermia. 2010;26(2):171-84.
72. Correia D, Kok HP, de Greef M, Bel A, van Wieringen N, Crezee J. Body conformal antennas for superficial hyperthermia: The impact of bending contact flexible microstrip applicators on their electromagnetic behavior. IEEE Trans Biomed Eng. 2009;56(12):2917-26.
73. van Wieringen N, Wiersma J, Zum Vorde Sive Vording PJ, Oldenborg S, Gelvich EA, Mazokhin VN, van Dijk JD, Crezee H. Characteristics and performance evaluation of the capacitive Contact Flexible Microstrip Applicator operating at 70 MHz for external hyperthermia. Int J Hyperthermia. 2009;25(7):542-53.
74. Crezee J, van Haaren PM, Westendorp H, de Greef M, Kok HP, Wiersma J, van Stam G, Sijbrands J, Zum Vorde Sive Vording PJ, van Dijk JD, Hulshof MC, Bel A. Improving locoregional hyperthermia delivery using the 3-D controlled AMC-8 phased array hyperthermia system: a preclinical study. Int J Hyperthermia. 2009;25(7):581-92.
75. Crezee J, Barendsen GW, Westermann AM, Hulshof MC, Haveman J, Stalpers LJ, Geijsen ED, Franken NA. Quantification of the contribution of hyperthermia to results of cervical cancer trials.
76. in regard to Plataniotis and Dale (Int J Radiat Oncol Biol Phys 2009;73:1538-1544). Int J Radiat Oncol Biol Phys. 2009;75(2):634-.
77. Kok HP, de Greef M, Correia D, Zum Vorde Sive Vording PJ, van Stam G, Gelvich EA, Crezee J. FDTD simulations to assess the performance of CFMA-434 applicators for superficial hyperthermia. Int J Hyperthermia. 2009;25(6):462-76.
78. de Greef M, van Eijk JC, Pool R, Crezee J, Bel A. Accelerated ray-tracing for radiotherapy dose calculations on a GPU. Med Phys. 2009;36(9):4095-102.
79. Kok HP, de Greef M, Bel A, Crezee J. Acceleration of high resolution temperature based optimisation for hyperthermia treatment planning using element grouping. Med Phys. 2009;36(8):3795-805.
80. Hulshof MC, van Haaren PM, van Lanschot JJ, Richel DJ, Fockens P, Oldenborg S, Geijsen ED, van Berge Henegouwen MI, Crezee J. Preoperative chemoradiation combined with regional hyperthermia for patients with resectable esophageal cancer. Int J Hyperthermia. 2009;25(1):79-85.
81. van Haaren PM, Hulshof MC, Kok HP, Oldenborg S, Geijsen ED, van Lanschot JJ, Crezee J. Relation between body size and temperatures during locoregional hyperthermia of oesophageal cancer patients. Int J Hyperthermia. 2008;24(8):663-74.
82. Kok HP, Van den Berg CA, van Haaren PM, Crezee J. Artefacts in intracavitary temperature measurements during regional hyperthermia. Phys Med Biol. 2007;52(17):5157-71.
83. Bergs JWJ, Franken NA, Haveman J, Geijsen ED, Crezee J, van Bree C. Hyperthermia, cisplatin and radiation trimodality treatment: A promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia. 2007;23(4):329-41.
84. Kok HP, van Haaren PM, van de Kamer JB, Crezee J. Theoretical comparison of intraluminal heating techniques. Int J Hyperthermia. 2007;23(4):395-411.
85. van Haaren PM, Kok HP, Van den Berg CA, Zum Vorde Sive Vording PJ, Oldenborg S, Stalpers LJ, Schilthuis MS, de Leeuw AA, Crezee J. On verification of hyperthermia treatment planning for cervical carcinoma patients. Int J Hyperthermia. 2007;23(3):303-14.
86. Wiersma J, van Wieringen N, Crezee H, van Dijk JD. Delineation of potential hot spots for hyperthermia treatment planning optimisation. Int J Hyperthermia. 2007;23(3):287-301.
87. van Haaren PM, Kok HP, Zum Vorde Sive Vording PJ, van Dijk JD, Hulshof MC, Fockens P, van Lanschot JJ, Crezee J. Reliability of temperature and SAR measurements at oesophageal tumour locations. Int J Hyperthermia. 2006;22(7):545-61.
88. Westerterp M, Omloo JM, Sloof GW, Hulshof MC, Hoekstra OS, Crezee H, Boellaard R, Vervenne WL, ten Kate FJ, van Lanschot JJ. Monitoring of response to preoperative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET. J Clin Gastroenterol. 2006;40(8 Suppl 4):S180-S.
89. Kok HP, van Haaren PM, van de Kamer JB, Zum Vorde Sive Vording PJ, Wiersma J, Hulshof MC, Geijsen ED, van Lanschot JJ, Crezee J. Prospective treatment planning to improve locoregional hyperthermia for oesophageal cancer. Int J Hyperthermia. 2006;22(5):375-89.
90. Westerterp M, Omloo JM, Sloof GW, Hulshof MC, Hoekstra OS, Crezee H, Boellaard R, Vervenne WL, ten Kate FJ, van Lanschot JJ. Monitoring of response to pre-operative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET. Int J Hyperthermia. 2006;22(2):149-60.
91. Kok HP, van Haaren PM, van de Kamer JB, Wiersma J, van Dijk JD, Crezee J. High resolution temperature based optimisation for hyperthermia treatment planning. Phys Med Biol. 2005;50(13):3127-41.
92. Kok HP, van Haaren PM, van Dijk J, Crezee J. On estimation of the temperature maximum in intraluminal or intracavitary hyperthermia. Int J Hyperthermia. 2005;21(4):287-304.
93. Albregts M, Hulshof MC, PJ ZVSV, van Lanschot JJ, Richel DJ, Crezee H, Fockens P, van Dijk JD, Gonzalez GD. A feasibility study in oesophageal carcinoma using deep loco-regional hyperthermia combined with concurrent chemotherapy followed by surgery. Int J Hyperthermia. 2004;20(6):647-59.
94. Hulshof MC, Raaymakers BW, Lagendijk JJ, Koot RW, Crezee H, Stalpers LJ, Gonzalez GD. A feasibility study of interstitial hyperthermia plus external beam radiotherapy in glioblastoma multiforme using the Multi ELectrode Current Source (MECS) system. Int J Hyperthermia. 2004;20(5):451-63.
95. van Vulpen M, Raaymakers BW, Lagendijk JJ, Crezee J, de Leeuw AA, van Moorselaar JR, Ligtvoet CM, Battermann JJ. Three-dimensional controlled interstitial hyperthermia combined with radiotherapy for locally advanced prostate carcinoma--a feasibility study. Int J Radiat Oncol Biol Phys. 2002;53(1):116-26.
96. Raaymakers BW, van Vulpen M, Lagendijk JJ, de Leeuw AA, Crezee J, Battermann JJ. Determination and validation of the actual 3D temperature distribution during interstitial hyperthermia of prostate carcinoma. Phys Med Biol. 2001;46(12):3115-31.
97. Kaatee RS, Nowak PC, van der Zee J, de Bree J, Kanis BP, Crezee H, Levendag PC, Visser AG. Clinical thermometry, using the 27 MHz multi-electrode current-source interstitial hyperthermia system in brain tumours. Radiother Oncol. 2001;59(2):227-31.
98. Raaymakers BW, Crezee J, Lagendijk JJ. Modelling individual temperature profiles from an isolated perfused bovine tongue. Phys Med Biol. 2000;45(3):765-80.
99. Kaatee RS, Crezee H, Visser AG. Temperature measurement errors with thermocouples inside 27 MHz current source interstitial hyperthermia applicators. Phys Med Biol. 1999;44(6):1499-511.
100. Crezee J, Kaatee RS, van der Koijk JF, Lagendijk JJ. Spatial steering with quadruple electrodes in 27 MHz capacitively coupled interstitial hyperthermia. Int J Hyperthermia. 1999;15(2):145-56.
101. van der Koijk JF, Crezee J, Lagendijk JJ. Thermal properties of capacitively coupled electrodes in interstitial hyperthermia. Phys Med Biol. 1998;43(1):139-53.
102. Raaymakers BW, Crezee J, Lagendijk JJ. Comparison of temperature distributions in interstitial hyperthermia: experiments in bovine tongues versus generic simulations. Phys Med Biol. 1998;43(5):1199-214.
103. van der Koijk JF, de Bree J, Crezee J, Lagendijk JJ. Numerical analysis of capacitively coupled electrodes for interstitial hyperthermia. Int J Hyperthermia. 1997;13(6):607-19.
104. van Leeuwen GM, Kotte AN, Crezee J, Lagendijk JJ. Tests of the geometrical description of blood vessels in a thermal model using counter-current geometries. Phys Med Biol. 1997;42(8):1515-32.
105. van der Koijk JF, Lagendijk JJ, Crezee J, de Bree J, Kotte AN, van Leeuwen GM, Battermann JJ. The influence of vasculature on temperature distributions in MECS interstitial hyperthermia: importance of longitudinal control. Int J Hyperthermia. 1997;13(4):365-85.
106. van Leeuwen GM, Kotte AN, de Bree J, van der Koijk JF, Crezee J, Lagendijk JJ. Accuracy of geometrical modelling of heat transfer from tissue to blood vessels. Phys Med Biol. 1997;42(7):1451-60.
107. Kaatee RS, Crezee J, Kanis AP, Lagendijk JJ, Levendag PC, Visser AG. Design of applicators for a 27 MHz multielectrode current source interstitial hyperthermia system; impedance matching and effective power. Phys Med Biol. 1997;42(6):1087-108.
108. Crezee J, van der Koijk JF, Kaatee RS, Lagendijk JJ. Implications of using thermocouple thermometry in 27 MHz capacitively coupled interstitial hyperthermia. Phys Med Biol. 1997;42(4):637-50.
109. Kaatee RS, Crezee H, Kanis BP, Lagendijk JJ, Levendag PC, Visser AG. Spatial temperature control with a 27 MHz current source interstitial hyperthermia system. Int J Radiat Oncol Biol Phys. 1997;37(1):189-97.
110. Kotte A, van Leeuwen G, de Bree J, van der KJ, Crezee H, Lagendijk J. A description of discrete vessel segments in thermal modelling of tissues. Phys Med Biol. 1996;41(5):865-84.
111. van der Koijk JF, Crezee J, van Leeuwen GM, Battermann JJ, Lagendijk JJ. Dose uniformity in MECS interstitial hyperthermia: the impact of longitudinal control in model anatomies. Phys Med Biol. 1996;41(3):429-44.
112. Lagendijk JJ, Crezee J, Hand JW. Dose uniformity in scanned focused ultrasound hyperthermia. Int J Hyperthermia. 1994;10(6):775-84.
113. Crezee J, Mooibroek J, Lagendijk JJ, van Leeuwen GM. The theoretical and experimental evaluation of the heat balance in perfused tissue. Phys Med Biol. 1994;39(5):813-32.
114. de Leeuw AA, Crezee J, Lagendijk JJ. Temperature and SAR measurements in deep-body hyperthermia with thermocouple thermometry. Int J Hyperthermia. 1993;9(5):685-97.
115. Crezee J, Lagendijk JJ. Temperature uniformity during hyperthermia: the impact of large vessels. Phys Med Biol. 1992;37(6):1321-37.
116. Bos CK, Crezee J, Mooibroek J, Lagendijk JJ. A perfusion technique for tongues to be used in bioheat transfer studies. Phys Med Biol. 1991;36(6):843-6.
117. Crezee J, Mooibroek J, Bos CK, Lagendijk JJ. Interstitial heating: experiments in artificially perfused bovine tongues. Phys Med Biol. 1991;36(6):823-33.
118. Crezee J, Lagendijk JJ. Experimental verification of bioheat transfer theories: measurement of temperature profiles around large artificial vessels in perfused tissue. Phys Med Biol. 1990;35(7):905-23.
119. Metselaar JW, Goovaerts HG, Crezee J. Generation of a fast and homogeneous temperature step. J Biochem Biophys Methods. 1987;14(4):233-42.
120. Metselaar JW, Crezee J, Goovaerts HG. Generation of a rapid step in the temperature of a papillary muscle. Med Biol Eng Comput. 1986;24(5):475-81.

Book chapters
1. Crezee H, Kaidar–Person O, Poortmans P. Locally Recurrent Disease. In “Breast Cancer: Essentials for Clinicians” (in press)
2. Franken N, Hovingh S, Oei A, Cobussen P, Rodermond H, Bergs J, Van Bree C, Stalpers L, Kok P, Barendsen GW, Crezee J. Radiosensitization with hyperthermia and chemotherapeutic agents: Effects on linear-quadratic parameters of radiation cell survival curves. In Ionizing Radiation / Book 1, ISBN 979-953-307-345-2, InTech, Editor M. Nenoi.
3. Mooibroek J, Crezee J, Lagendijk JJW. Basics of thermal models. Chapter 19 in `Thermoradiotherapy ad Thermochemotherapy, vol !. Biology, Physiology and Physics. Seegenschmiedt MH, Fessenden P, Vernon CC (eds), Berlin± Springer-Verlag, 1995, pp 425-37.
4. Crezee J, Mooibroek J, Lagendijk JJW. Thermal model verification in interstitial hyperthermia. In ´interstitial and intracavitary thermoradiotherapy´, Seegenschmiedt MH, Sauer R (eds), Berlin Springer, 1993, pp 147-53.

 

Research programmes

Hyperthermia

1) The development of new hyperthermia techniques

2) The development and application of hyperthermia treatment planning

3) Clinical hyperthermia research

4) Working mechanisms of hyperthermia

Faculty
Dr. J. Crezee PhD

Postdocs
Dr. A. van der Horst
H.P. Kok PhD

PhD Students
Ir. P. Agnass
M. Bennis
M. Ijff MSc
C.M. van Leeuwen MSc
Drs. G. Schooneveldt MA MSc
S. Gavazzi MSc (University of Utrecht)

Others
G. van Stam

Dr. A. Bel (Innovative image guided radiotherapy)

Prof. dr. C.R.N. Rasch (Image guided and physics application in the clinic)

Other research related activities
  • None reported
Current research funding
  • KWF Kankerbestrijding
  • Medlogix Srl
  • ZonMw