• Principal Investigator
  • Male

Prof. dr. S. Repping

Position: Professor
Main activities: Patient care, Research
Specialisation: Human Reproductive Biology
foto S. Repping is one of the AMC Principal Investigators
Focus of research:

Mission Statement
We aim to perform translational research in the field of Reproduction and Development.

Goals & Ambition
It is our ambition to be at the international front of Reproductive Biology research. Although both clinical evaluation studies and fundamental research are carried out within the department, are focus lies in bringing scientific developments to clinical application. The integration of patient care and research within our department provides the proper framework for the realization of this goal and ambition. Within the lines of research in our department we have the following goals:

Spermatogenesis & Stem Cells (dr. Ans van Pelt): We aim to unravel the mechanism of spermatogonial stem cell renewal and differentiation and to determine which genetic aberrations can lead to spermatogenic failure. We aim to develop a clinical application of human SSCs as a way to preserve reproductive potential in young boys diagnosed with cancer. In addition, we are interested in studying the plasticity of spermatogonial stem cells and their ability to form pluripotent cells that are of potential use for Regenerative Medicine.

Preimplantation Embryology (dr. Sebastiaan Mastenbroek): We aim to understand the development of human preimplantation embryos focusing on chromosomal status and developmental competence and to determine the optimal in vitro conditions for preimplantation embryos by conducting laboratory oriented evaluation studies (RCTs). More precisely, we aim to understand the origin and fate of mosaic embryos, i.e. embryos that contain both euploid and aneuploid cells.

Genomic stability of reproductive cells (dr. Geert Hamer): We aim to understand the genomic stability of both male and female gametes as well as the early embryo. Genomic instability can lead to infertilty as well as to developmental disorders and congenital malformations.

Pregnancy disorders (dr. Gijs Afink): We aim to understand the patho-physiology of preeclampsia and premature labour using mouse models and clinical samples.
 

AMC themes: Reproduction and development
Departments: Center for Reproductive Medicine, Obstetrics and Gynaecology
Cissen M. How to diagnose and treat male subfertility. S.l.: s.n.; 2017. 208p. ISBN 978-94-6233-455-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S, Braat DDM; copromotor(s): van Wely M, de Bruin JP)
Kleijkers SHM, Mantikou E, Slappendel E, Consten D, van Echten-Arends J, Wetzels AM, van Wely M, Smits LJM, van Montfoort APA, Repping S, Dumoulin JCM, Mastenbroek S, Reply II: Embryo culture media effects. HUM REPROD 2017;32 (3):717-718 [PubMed]
Tjon-Kon-Fat RI, Tajik P, Zafarmand MH, Bensdorp AJ, Bossuyt PMM, Oosterhuis GJE, van Golde R, Repping S, Lambers MDA, Slappendel E, Perquin D, Pelinck MJ, Gianotten J, Maas JWM, Eijkemans MJC, van der Veen F, Mol BW, van Wely M, IVF or IUI as first-line treatment in unexplained subfertility: the conundrum of treatment selection markers. HUM REPROD 2017;ahead of print [PubMed]
Wong KM, van Wely M, Mol F, Repping S, Mastenbroek S, Fresh versus frozen embryo transfers in assisted reproduction. COCHRANE DB SYST REV 2017;2017 (3):CD011184 [PubMed]
Cissen M, Bensdorp A, Cohlen BJ, Repping S, de Bruin JP, van Wely M, Assisted reproductive technologies for male subfertility. COCHRANE DB SYST REV 2016;2016 (2):CD000360 [PubMed]
Cissen M, Meijerink AM, D'Hauwers KW, Meissner A, van der Weide N, Mochtar MH, de Melker AA , Ramos L, Repping S, Braat DDM, Fleischer K, van Wely M, Prediction model for obtaining spermatozoa with testicular sperm extraction in men with non-obstructive azoospermia. HUM REPROD 2016;31 (9):1934-1941 [PubMed]
Cissen M, van Wely M, Scholten I, Mansell S, de Bruin JP, Mol BW, Braat D, Repping S, Hamer G, Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis. PLOS ONE 2016;11 (11):e0165125 [PubMed]
de Groot M, Dancet E, Repping S, Goddijn M, Stoop D, van der Veen F, Gerrits T, Perceptions of oocyte banking from women intending to circumvent age-related fertility decline. ACTA OBSTET GYN SCAN 2016;95 (12):1396-1401 [PubMed]
Hendriks S, Hessel M, Mochtar MH, Meissner A, van der Veen F, Repping S, Dancet EAF, Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes. HUM REPROD 2016;31 (8):1738-1748 [PubMed]
Kleijkers SHM, Mantikou E, Slappendel E, Consten D, van Echten-Arends J, Wetzels AM, van Wely M, Smits LJM, van Montfoort APA, Repping S, Dumoulin JCM, Mastenbroek S, Influence of embryo culture medium (G5 and HTF) on pregnancy and perinatal outcome after IVF: a multicenter RCT. HUM REPROD 2016;31 (10):2219-2230 [PubMed]
Lankreijer K, D'Hooghe T, Sermeus W, van Asseldonk FPM, Repping S, Dancet EAF, Development and validation of the FertiMed questionnaire assessing patients' experiences with hormonal fertility medication. HUM REPROD 2016;31 (8):1799-1808 [PubMed]
Leushuis E, Wetzels A, van der Steeg JW, Steures P, Bossuyt PMM, van Trooyen N, Repping S, van der Horst FAL, Hompes PGAH, Mol BWJ, van der Veen F, Reducing Inter-Laboratory Differences between Semen Analyses Using Z Score and Regression Transformations. INT J FERTIL STERIL 2016;9 (4):534-540 [PubMed]
Mantikou E, Bruning O, Mastenbroek S, Repping S, Breit TM, de Jong M, Evaluation of ribonucleic acid amplification protocols for human oocyte transcriptome analysis. FERTIL STERIL 2016;105 (2):511-9.e4 [PubMed]
Mantikou E, Jonker MJ, Wong KM, van Montfoort APA, de Jong M, Breit TM, Repping S, Mastenbroek S, Factors affecting the gene expression of in vitro cultured human preimplantation embryos. HUM REPROD 2016;31 (2):298-311 [PubMed]
Masliukaite I, Hagen JM, Jahnukainen K, Stukenborg JB, Repping S, van der Veen F, van Wely M, van Pelt AMM, Establishing reference values for age-related spermatogonial quantity in prepubertal human testes: a systematic review and meta-analysis. FERTIL STERIL 2016;106 (7):1652-+ [PubMed]
Meijerink AM, Cissen M, Mochtar MH, Fleischer K, Thoonen I, de Melker AA , Meissner A, Repping S, Braat DDM, van Wely M, Ramos L, Prediction model for live birth in ICSI using testicular extracted sperm. HUM REPROD 2016;31 (9):1942-1951 [PubMed]
Meijerink AM, Ramos L, Janssen AJWM, Maas-van Schaaijk NM, Meissner A, Repping S, Mochtar MH, Braat DDM, Fleischer K, Behavioral, cognitive, and motor performance and physical development of five-year-old children who were born after intracytoplasmic sperm injection with the use of testicular sperm. FERTIL STERIL 2016;106 (7):1673-+ [PubMed]
Mulder CL, Zheng Y, Jan SZ, Struijk RB, Repping S, Hamer G, van Pelt AMM, Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases. HUM REPROD UPDATE 2016;22 (5):561-573 [PubMed]
Seggers J, Pontesilli M, Ravelli ACJ, Painter RC, Hadders-Algra M, Heineman MJ, Repping S, Mol BWJ, Roseboom TJ, Ensing S, Effects of in vitro fertilization and maternal characteristics on perinatal outcomes: a population-based study using siblings. FERTIL STERIL 2016;105 (3):590-+ [PubMed]
Tjon-Kon-Fat RI, Bensdorp AJ, Scholten I, Repping S, van Wely M, Mol BWJ, van der Veen F, IUI and IVF for unexplained subfertility: where did we go wrong?. HUM REPROD 2016;31 (12):2665-2667 [PubMed]
Verver DE, Zheng Y, Speijer D, Hoebe R, Dekker HL, Repping S, Stap J, Hamer G, Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress. INT J MOL SCI 2016;17 (11):1782 [PubMed]
Visser M, Mochtar MH, de Melker AA , van der Veen F, Repping S, Gerrits T, Psychosocial counselling of identifiable sperm donors. HUM REPROD 2016;31 (5):1066-1074 [PubMed]
Zhang JJ, Merhi Z, Yang M, Bodri D, Chavez-Badiola A, Repping S, van Wely M, Minimal stimulation IVF vs conventional IVF: a randomized controlled trial. AM J OBSTET GYNECOL 2016;214 (1):96.e1-96.e8 [PubMed]
Balkenende EME, Dahhan T, Repping S, de Melker AA, van der Veen F, Goddijn M, Eicelvitrificatie: voor wie eigenlijk? Een dwarsdoorsnede-onderzoek. NED TIJDSCHR GENEESKD 2015;159:A9361 [PubMed]
Bensdorp AJ, Tjon-Kon-Fat RI, Bossuyt PMM, Koks CAM, Oosterhuis GJE, Hoek A, Hompes PGA, Broekmans FJM, Verhoeve HR, de Bruin JP, van Golde R, Repping S, Cohlen BJ, Lambers MDA, van Bommel PF, Slappendel E, Perquin D, Smeenk JM, Pelinck MJ, Gianotten J, Hoozemans DA, Maas JWM, Eijkemans MJC, van der Veen F, Mol BWJ, van Wely M, Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation. BMJ-BRIT MED J 2015;350:g7771 [PubMed]
Ensing S, Abu-Hanna A, Roseboom TJ, Repping S, van der Veen F, Mol BWJ, Ravelli ACJ, Risk of poor neonatal outcome at term after medically assisted reproduction: a propensity score-matched study. FERTIL STERIL 2015;104 (2):384-90.e1 [PubMed]
Hendriks S, Dancet EAF, van Pelt AMM, Hamer G, Repping S, Artificial gametes: a systematic review of biological progress towards clinical application. HUM REPROD UPDATE 2015;21 (3):285-296 [PubMed]
Hendriks S, Dondorp W, de Wert G, Hamer G, Repping S, Dancet EAF, Potential consequences of clinical application of artificial gametes: a systematic review of stakeholder views. HUM REPROD UPDATE 2015;21 (3):297-309 [PubMed]
Kamphuis EI, van Wely M, Repping S, van der Veen F, de Groot CJM, Hompes P, Mol BWJ, Kazemier BM, Should the individual preterm birth risk be incorporated into the embryo transfer policy in in vitro fertilisation? A decision analysis. BJOG-INT J OBSTET GY 2015;122 (6):825-833 [PubMed]
Kleijkers SHM, Eijssen LMT, Coonen E, Derhaag JG, Mantikou E, Jonker MJ, Mastenbroek S, Repping S, Evers JLH, Dumoulin JCM, van Montfoort APA, Differences in gene expression profiles between human preimplantation embryos cultured in two different IVF culture media. HUM REPROD 2015;30 (10):2303-2311 [PubMed]
Kop PAL, van Wely M, Mol BW, de Melker AA , Janssens PMW, Arends B, Curfs MHJM, Kortman M, Nap A, Rijnders E, Roovers JPWR, Ruis H, Simons AHM, Repping S, van der Veen F, Mochtar MH, Intrauterine insemination or intracervical insemination with cryopreserved donor sperm in the natural cycle: a cohort study. HUM REPROD 2015;30 (3):603-607 [PubMed]
Moolenaar LM, Cissen M, de Bruin JP, Hompes PGA, Repping S, van der Veen F, Mol BWJ, Cost-effectiveness of assisted conception for male subfertility. REPROD BIOMED ONLINE 2015;30 (6):659-666 [PubMed]
Nickkholgh B. Genetic causes and treatment of spermatogenic failure. S.l.: s.n.; 2015. 133p. ISBN 978-1-4951-5840-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S; copromotor(s): van Pelt AMM)
Nickkholgh B, Korver CM, van Daalen SKM, van Pelt AMM, Repping S, AZFc deletions do not affect the function of human spermatogonia in vitro. MOL HUM REPROD 2015;21 (7):553-562 [PubMed]
Pontesilli M, Painter RC, Grooten IJ, van der Post JA, Mol BW, Vrijkotte TGM, Repping S, Roseboom TJ, Subfertility and assisted reproduction techniques are associated with poorer cardiometabolic profiles in childhood. REPROD BIOMED ONLINE 2015;30 (3):258-267 [PubMed]
Scholten I, Chambers GM, van Loendersloot L, van der Veen F, Repping S, Gianotten J, Hompes PGA, Ledger W, Mol BWJ, Impact of assisted reproductive technology on the incidence of multiple-gestation infants: a population perspective. FERTIL STERIL 2015;103 (1):179-183 [PubMed]
Tjon-Kon-Fat RI, Bensdorp AJ, Bossuyt PMM, Koks C, Oosterhuis GJE, Hoek A, Hompes P, Broekmans FJ, Verhoeve HR, de Bruin JP, van Golde R, Repping S, Cohlen BJ, Lambers MDA, van Bommel PF, Slappendel E, Perquin D, Smeenk J, Pelinck MJ, Gianotten J, Hoozemans DA, Maas JWM, Groen H, Eijkemans MJC, van der Veen F, Mol BWJ, van Wely M, Is IVF-served two different ways-more cost-effective than IUI with controlled ovarian hyperstimulation?. HUM REPROD 2015;30 (10):2331-2339 [PubMed]
van Wely M, Barbey N, Meissner A, Repping S, Silber SJ, Live birth rates after MESA or TESE in men with obstructive azoospermia: is there a difference?. HUM REPROD 2015;30 (4):761-766 [PubMed]
Verver DE. SMC5/6: Shaping, protecting and preparing the genome for safe reproduction. S.l.: s.n.; 2015. 123p. ISBN 978-94-6233-048-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S; copromotor(s): Hamer G)
Youssef MMA, Mantikou E, van Wely M, van der Veen F, Al-Inany HG, Repping S, Mastenbroek S, Culture media for human pre-implantation embryos in assisted reproductive technology cycles. COCHRANE DB SYST REV 2015;2015 (11):CD007876 [PubMed]
Chikhovskaya JV, van Daalen SKM, Korver CM, Repping S, van Pelt AMM, Mesenchymal origin of multipotent human testis-derived stem cells in human testicular cell cultures. MOL HUM REPROD 2014;20 (2):155-167 [PubMed]
Cutas D, Dondorp W, Swierstra T, Repping S, de Wert G, Artificial gametes: perspectives of geneticists, ethicists and representatives of potential users. MED HEALTH CARE PHIL 2014;17 (3):339-345 [PubMed]
Fleur Dancet EA, d'Hooghe TM, van der Veen F, Bossuyt P, Sermeus W, Mol BW, Repping S, "Patient-centered fertility treatment": what is required?. FERTIL STERIL 2014;101 (4):924-926 [PubMed]
Glujovsky D, Riestra B, Sueldo C, Fiszbajn G, Repping S, Nodar F, Papier S, Ciapponi A, Vitrification versus slow freezing for women undergoing oocyte cryopreservation. COCHRANE DB SYST REV 2014;2014 (9):CD010047 [PubMed]
Hendriks S, Dancet EAF, Meissner A, van der Veen F, Mochtar MH, Repping S, Perspectives of infertile men on future stem cell treatments for nonobstructive azoospermia. REPROD BIOMED ONLINE 2014;28 (5):650-657 [PubMed]
Leushuis E, van der Steeg JW, Steures P, Repping S, Bossuyt PMM, Mol BWJ, Hompes PGA, van der Veen F, Semen analysis and prediction of natural conception. HUM REPROD 2014;29 (7):1360-1367 [PubMed]
Mastenbroek S, Repping S, Preimplantation genetic screening: back to the future. HUM REPROD 2014;29 (9):1846-1850 [PubMed]
Nickkholgh B, Mizrak SC, Korver CM, van Daalen SKM, Meissner A, Repping S, van Pelt AMM, Enrichment of spermatogonial stem cells from long-term cultured human testicular cells. FERTIL STERIL 2014;102 (2):558-565.e5 [PubMed]
Nickkholgh B, Mizrak SC, van Daalen SKM, Korver CM, Sadri-Ardekani H, Repping S, van Pelt AMM, Genetic and epigenetic stability of human spermatogonial stem cells during long-term culture. FERTIL STERIL 2014;102 (6):1700-7.e1 [PubMed]
Sadri-Ardekani H, Homburg CH, van Capel TMM, van den Berg H, van der Veen F, van der Schoot CE, van Pelt AMM, Repping S, Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study. FERTIL STERIL 2014;101 (4):1072-1078.e1 [PubMed]
van Loendersloot L, Repping S, Bossuyt PMM, van der Veen F, van Wely M, Prediction models in in vitro fertilization; where are we? A mini review. J ADVANC RES 2014;5 (3):295-301 [PubMed]
van Loendersloot L, van Wely M, van der Veen F, Bossuyt P, Repping S, Selection of embryos for transfer in IVF: ranking embryos based on their implantation potential using morphological scoring. REPROD BIOMED ONLINE 2014;29 (2):222-230 [PubMed]
Verver DE, Langedijk NSM, Jordan PW, Repping S, Hamer G, The SMC5/6 complex is involved in crucial processes during human spermatogenesis. BIOL REPROD 2014;91 (1):22 [PubMed]
Visser L. Genetic studies in spermatogenic failure. S.l.: s.n.; 2014. 223p. ISBN 9789082284904 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S, van der Veen F; copromotor(s): van Pelt AMM)
Wong KM, Mastenbroek S, Repping S, Cryopreservation of human embryos and its contribution to in vitro fertilization success rates. FERTIL STERIL 2014;102 (1):19-26 [PubMed]
Wong KM, Repping S, Mastenbroek S, Limitations of embryo selection methods. SEMIN REPROD MED 2014;32 (2):127-133 [PubMed]
Beukers F, van der Heide M, Middelburg KJ, Cobben JM, Mastenbroek S, Breur R, van der Lee JH, Hadders-Algra M, Bos AF, Kok JH [Contributors: Cobben JM, van der Heide M, Houtzager BA , Kok JH, Mastenbroek S, Repping S, Twisk M, van der Veen F, Bos AF, Haadsma M, Hadders-Algra M, Heineman MJ, van Hoften J, Jongbloed-Pereboom M, Keating P, Middelburg K, Seggers J]] , Morphologic abnormalities in 2-year-old children born after in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening: follow-up of a randomized controlled trial. FERTIL STERIL 2013;99 (2):408-413 [PubMed]
Chikhovskaya JV. The potency of human testicular stem cells. s.l.: s.n.; 2013. 166p. ISBN 0789461085283 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S; copromotor(s): van Pelt AMM)
Lange J, Noordam MJ, van Daalen SKM, Skaletsky H, Clark BA, Macville MV, Page DC, Repping S, Intrachromosomal homologous recombination between inverted amplicons on opposing Y-chromosome arms. GENOMICS 2013;102 (4):257-264 [PubMed]
Mantikou E. Improving embryo quality in assisted reproduction. s.l.: s.n.; 2013. 181p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S; copromotor(s): Mastenbroek S)
Mantikou E, Bontekoe S, van Wely M, Seshadri S, Repping S, Mastenbroek S, Low oxygen concentrations for embryo culture in assisted reproductive technologies. HUM REPROD UPDATE 2013;19 (3):209 [PubMed]
Mantikou E, van Echten-Arends J, Sikkema-Raddatz B, van der Veen F, Repping S, Mastenbroek S, Temporal and developmental-stage variation in the occurrence of mitotic errors in tripronuclear human preimplantation embryos. BIOL REPROD 2013;89 (2):42 [PubMed]
Mantikou E, Youssef MAFM, van Wely M, van der Veen F, Al-Inany HG, Repping S, Mastenbroek S, Embryo culture media and IVF/ICSI success rates: a systematic review. HUM REPROD UPDATE 2013;19 (3):210-220 [PubMed]
Mastenbroek S, Twisk M, van der Veen F, Repping S, Preimplantation genetic screening: a systematic review and meta-analysis of RCTs : Erratum. HUM REPROD UPDATE 2013;19 (2):206
Repping S, Essentiality of biological plausibility. FERTIL STERIL 2013;99 (6):1557 [PubMed]
Sadri-Ardekani H, Akhondi MM, Vossough P, Maleki H, Sedighnejad S, Kamali K, Ghorbani B, van Wely M, van der Veen F, Repping S, Parental attitudes toward fertility preservation in boys with cancer: context of different risk levels of infertility and success rates of fertility restoration. FERTIL STERIL 2013;99 (3):796-802 [PubMed]
Struijk RB, Mulder CL, van der Veen F, van Pelt AMM, Repping S, Restoring fertility in sterile childhood cancer survivors by autotransplanting spermatogonial stem cells: are we there yet?. BIOMED RES INT 2013;2013:903142 [PubMed]
van Loendersloot LL. Predicting IVF outcome. s.l.: s.n.; 2013. 194p. ISBN 9789461919335 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Bossuyt PMM; copromotor(s): van Wely M, Repping S)
van Loendersloot LL, van Wely M, Repping S, Bossuyt PMM, van der Veen F, Individualized decision-making in IVF: calculating the chances of pregnancy. HUM REPROD 2013;28 (11):2972-2980 [PubMed]
van Loendersloot L, van Wely M, Goddijn M, Repping S, Bossuyt P, van der Veen F, Pregnancy and twinning rates using a tailored embryo transfer policy. REPROD BIOMED ONLINE 2013;26 (5):462-469 [PubMed]
Verver DE, van Pelt AMM, Repping S, Hamer G, Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis. CELL DEATH DIS 2013;4:e749 [PubMed]
Beukers F, Houtzager BA, Paap MCS, Middelburg KJ, Hadders-Algra M, Bos AF, Kok JH [Contributors: Beukers F, Cobben JM, van der Heide M, Houtzager BA , Kok JH, Koomen A, Repping S, Silberbusch L, Twisk M, Mastenbroek S, van der Veen F, Bos AF, Haadsma M, Hadders-Algra M, Heineman MJ, van Hoften J, Jongbloed-Pereboom M, Keating P, Middelburg K, Seggers J]] , Parental psychological distress and anxiety after a successful IVF/ICSI procedure with and without preimplantation genetic screening: Follow-up of a randomised controlled trial. EARLY HUM DEV 2012;88 (9):725-730 [PubMed]
Bontekoe S, Mantikou E, van Wely M, Seshadri S, Repping S, Mastenbroek S, Low oxygen concentrations for embryo culture in assisted reproductive technologies. COCHRANE DB SYST REV 2012;2012 (7):CD008950 [PubMed]
Chikhovskaya JV, Jonker MJ, Meissner A, Breit TM, Repping S, van Pelt AMM, Human testis-derived embryonic stem cell-like cells are not pluripotent, but possess potential of mesenchymal progenitors. HUM REPROD 2012;27 (1):210-221 [PubMed]
Handyside AH, Montag M, Magli MC, Repping S, Harper J, Schmutzler A, Vesela K, Gianaroli L, Geraedts J, Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation. EUR J HUM GENET 2012;20 (7):742-747 [PubMed]
Jan SZ, Hamer G, Repping S, de Rooij DG, van Pelt AMM, Vormer TL, Molecular control of rodent spermatogenesis. BBA-MOL BASIS DIS 2012;1822 (12):1838-1850 [PubMed]
Maiburg M, Repping S, Giltay J, The genetic origin of Klinefelter syndrome and its effect on spermatogenesis. FERTIL STERIL 2012;98 (2):253-260 [PubMed]
Mantikou E, Wong KM, Repping S, Mastenbroek S, Molecular origin of mitotic aneuploidies in preimplantation embryos. BBA-MOL BASIS DIS 2012;1822 (12):1921-1930 [PubMed]
Musters AM. Reproductive choices in women with poor ovarian reserve and recurrent miscarriages. s.l.: s.n.; 2012. 173p. ISBN 9739090265131 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Repping S; copromotor(s): Goddijn M, Mochtar MH)
Musters AM, van Wely M, Mastenbroek S, Kaaijk EM, Repping S, van der Veen F, Mochtar MH, The effect of recombinant LH on embryo quality: a randomized controlled trial in women with poor ovarian reserve. HUM REPROD 2012;27 (1):244-250 [PubMed]
Noordam MJ. The Y chromome: a sole survivor. s.l.: s.n.; 2012. 153p. ISBN 9789088914072 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S, van der Veen F; copromotor(s): van Pelt AMM)
Repping S, Circle of life: The fascinating aspects of reproduction Preface. BBA-MOL BASIS DIS 2012;1822 (12):1837 [PubMed]
Steenvoorden MMC, Cornelissen M, van Leeuwen E, Schuurman NM, Egberink HF, Berkhout B, van der Veen F, Repping S, Integration of immunodeficiency virus in oocytes via intracytoplasmic injection: possible but extremely unlikely. FERTIL STERIL 2012;98 (1):173-177 [PubMed]
van Weert JM. Male subfertility and assisted reproduction. The quest for the ultimate treatment strategy. s.l.: s.n.; 2012. 158p. ISBN 9789064645280 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F; copromotor(s): Mol BWJ, Repping S)
Carlomagno G. Factors driving spermatogonial stem cell fate. s.l.: s.n.; 2011. 124p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S; copromotor(s): van Pelt AMM)
Custers IM, König TE, Broekmans FJ, Hompes PGA, Kaaijk E, Oosterhuis J, Mochtar MH, Repping S, van Wely M, Steures P, van der Veen F, Mol BWJ, Couples with unexplained subfertility and unfavorable prognosis: a randomized pilot trial comparing the effectiveness of in vitro fertilization with elective single embryo transfer versus intrauterine insemination with controlled ovarian stimulation. FERTIL STERIL 2011;96 (5):1107-11.e1 [PubMed]
Franssen MTM, Musters AM, van der Veen F, Repping S, Leschot NJ, Bossuyt PMM, Goddijn M, Korevaar JC, Reproductive outcome after PGD in couples with recurrent miscarriage carrying a structural chromosome abnormality: a systematic review. HUM REPROD UPDATE 2011;17 (4):467-475 [PubMed]
Geraedts J, Montag M, Magli MC, Repping S, Handyside A, Staessen C, Harper J, Schmutzler A, Collins J, Goossens V, van der Ven H, Vesela K, Gianaroli L, Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical results. HUM REPROD 2011;26 (11):3173-3180 [PubMed]
Magli MC, Montag M, Köster M, Muzi L, Geraedts J, Collins J, Goossens V, Handyside AH, Harper J, Repping S, Schmutzler A, Vesela K, Gianaroli L, Polar body array CGH for prediction of the status of the corresponding oocyte. Part II: technical aspects. HUM REPROD 2011;26 (11):3181-3185 [PubMed]
Mastenbroek S. Preimplantation genetic screening. A reappraisal. s.l.: s.n.; 2011. 127p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Repping S; copromotor(s): Heineman MJ, Bossuyt PM)
Mastenbroek S, Twisk M, van der Veen F, Repping S, Preimplantation genetic screening: a systematic review and meta-analysis of RCTs. HUM REPROD UPDATE 2011;17 (4):454-466 [PubMed]
Mastenbroek S, van der Veen F, Aflatoonian A, Shapiro B, Bossuyt P, Repping S, Embryo selection in IVF. HUM REPROD 2011;26 (5):964-966 [PubMed]
Musters AM, Repping S, Korevaar JC, Mastenbroek S, Limpens J, van der Veen F, Goddijn M, Pregnancy outcome after preimplantation genetic screening or natural conception in couples with unexplained recurrent miscarriage: a systematic review of the best available evidence. FERTIL STERIL 2011;95 (6):2153-2157 [PubMed]
Noordam MJ, van Daalen SKM, Hovingh SE, Korver CM, van der Veen F, Repping S, A novel partial deletion of the Y chromosome azoospermia factor c region is caused by non-homologous recombination between palindromes and may be associated with increased sperm counts. HUM REPROD 2011;26 (3):713-723 [PubMed]
Noordam MJ, Westerveld GH, Hovingh SE, van Daalen SKM, Korver CM, van der Veen F, van Pelt AMM, Repping S, Gene copy number reduction in the azoospermia factor c (AZFc) region and its effect on total motile sperm count. HUM MOL GENET 2011;20 (12):2457-2463 [PubMed]
Sadri-Ardekani H. Spermatogonial stem cell autotransplantation. Towards clinical application’. s.l.: s.n.; 2011. -p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Repping S, van der Veen F; copromotor(s): van Pelt AMM)
Sadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AMM, In Vitro Propagation of Human Prepubertal Spermatogonial Stem Cells. JAMA-J AM MED ASSOC 2011;305 (23):2416-2418 [PubMed]
Twisk M. Current value of preimplantation genetic screening. s.l.: s.n.; 2011. 131p. ISBN 9789090263762 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Heineman MJ; copromotor(s): Repping S, Korevaar JC)
van der Steeg JW, Steures P, Eijkemans MJC, F Habbema JD, Hompes PGA, Kremer JAM, van der Leeuw-Harmsen L, Bossuyt PMM, Repping S, Silber SJ, Mol BWJ, van der Veen F, Role of semen analysis in subfertile couples. FERTIL STERIL 2011;95 (3):1013-1019 [PubMed]
van Echten-Arends J, Mastenbroek S, Sikkema-Raddatz B, Korevaar JC, Heineman MJ, van der Veen F, Repping S, Chromosomal mosaicism in human preimplantation embryos: a systematic review. HUM REPROD UPDATE 2011;17 (5):620-627 [PubMed]
van Loendersloot LL, Moolenaar LM, Mol BWJ, Repping S, van der Veen F, Goddijn M, Expanding reproductive lifespan: a cost-effectiveness study on oocyte freezing. HUM REPROD 2011;26 (11):3054-3060 [PubMed]
van Loendersloot LL, van Wely M, Repping S, van der Veen F, Bossuyt PMM, Templeton prediction model underestimates IVF success in an external validation. REPROD BIOMED ONLINE 2011;22 (6):597-602 [PubMed]
Visser L, Westerveld GH, Xie F, van Daalen SKM, van der Veen F, Lombardi MP, Repping S, A comprehensive gene mutation screen in men with asthenozoospermia. FERTIL STERIL 2011;95 (3):1020-U213 [PubMed]
Carlomagno G, van Bragt MPA, Korver CM, Repping S, de Rooij DG, van Pelt AMM, BMP4-Induced Differentiation of a Rat Spermatogonial Stem Cell Line Causes Changes in Its Cell Adhesion Properties. BIOL REPROD 2010;83 (5):742-749 [PubMed]
Cohn DM, Repping S, Büller HR, Meijers JCM, Middeldorp S, Increased sperm count may account for high population frequency of factor V Leiden. J THROMB HAEMOST 2010;8 (3):513-516 [PubMed]
Cornelissen M, Zorgdrager F, Blom P, Jurriaans S, Repping S, van Leeuwen E, Bakker M, Berkhout B, van der Kuyl AC, Lack of Detection of XMRV in Seminal Plasma from HIV-1 Infected Men in The Netherlands. PLOS ONE 2010;5 (8):e12040 [PubMed]
de Melker AA, Verhoeve HR, Goddijn M, van der Veen F, Repping S, Voortplanting met behulp van gevitrificeerde oöcyten. NED TIJDSCHR GENEESKD 2010;154:A1715 [PubMed]
Geraedts J, Collins J, Gianaroli L, Goossens V, Handyside A, Harper J, Montag M, Repping S, Schmutzler A, What next for preimplantation genetic screening? A polar body approach!. HUM REPROD 2010;25 (3):575-577 [PubMed]
Hughes JF, Skaletsky H, Pyntikova T, Graves TA, van Daalen SKM, Minx PJ, Fulton RS, McGrath SD, Locke DP, Friedman C, Trask BJ, Mardis ER, Warren WC, Repping S, Rozen S, Wilson RK, Page DC, Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content. NATURE 2010;463 (7280):536-539 [PubMed]
Leushuis E, van der Steeg JW, Steures P, Repping S, Bossuyt PMM, Blankenstein MA, Mol BWJ, van der Veen F, Hompes PGA, Reproducibility and reliability of repeated semen analyses in male partners of subfertile couples. FERTIL STERIL 2010;94 (7):2631-2635 [PubMed]
Mizrak SC , Chikhovskaya JV, Sadri-Ardekani H, van Daalen S, Korver CM, Hovingh SE, Roepers-Gajadien HL, Raya A, Fluiter K, de Reijke TM, de la Rosette JJMCH, Knegt AC, Belmonte JC, van der Veen F, de rooij DG , Repping S, van Pelt AMM, Embryonic stem cell-like cells derived from adult human testis. HUM REPROD 2010;25 (1):158-167 [PubMed]
Musters AM, Twisk M, Leschot NJ, Oosterwijk C, Korevaar JC, Repping S, van der Veen F, Goddijn M, Perspectives of couples with high risk of transmitting genetic disorders. FERTIL STERIL 2010;94 (4):1239-1243 [PubMed]
Nickkholgh B, Noordam MJ, Hovingh SE, van Pelt AMM, van der Veen F, Repping S, Y chromosome TSPY copy numbers and semen quality. FERTIL STERIL 2010;94 (5):1744-1747 [PubMed]
Sadri-Ardekani H, Mizrak SC , van Daalen SKM, Korver CM, Roepers-Gajadien HL, Koruji M, Hovingh S, de Reijke TM, de la Rosette JJMCH, van der Veen F, de rooij DG , Repping S, van Pelt AMM, Propagation of Human Spermatogonial Stem Cells In Vitro (vol 302, pg 2127, 2009). JAMA-J AM MED ASSOC 2010;303 (5):422
van Loendersloot LL, van Wely M, Limpens J, Bossuyt PMM, Repping S, van der Veen F, Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis. HUM REPROD UPDATE 2010;16 (6):577-589 [PubMed]
Visser L, Repping S, Unravelling the genetics of spermatogenic failure. REPRODUCTION 2010;139 (2):303-307 [PubMed]
Bensdorp AJ, Slappendel E, Koks C, Oosterhuis J, Hoek A, Hompes P, Broekmans F, Verhoeve H, de Bruin JP, van Weert JM, Traas M, Maas J, Beckers N, Repping S, Mol BW, van der Veen F, van Wely M, The INeS study: prevention of multiple pregnancies: a randomised controlled trial comparing IUI COH versus IVF e SET versus MNC IVF in couples with unexplained or mild male subfertility. BMC WOMENS HEALTH 2009;9 (1):35 [PubMed]
Harper JC, Repping S, Hill D, Current controversies in prenatal diagnosis 1: Is aneuploidy testing by PGD indicated for all infertile patients undergoing IVF?. PRENATAL DIAG 2009;29 (1):2-5 [PubMed]
Lange J, Skaletsky H, van Daalen SKM, Embry SL, Korver CM, Brown LG, Oates RD, Silber S, Repping S, Page DC, Isodicentric Y Chromosomes and Sex Disorders as Byproducts of Homologous Recombination that Maintains Palindromes. CELL 2009;138 (5):855-869 [PubMed]
Leushuis E, van der Steeg JW, Steures P, Repping S, Schöls W, van der Veen F, Mol BWJ, Hompes PGA, Immunoglobulin G antisperm antibodies and prediction of spontaneous pregnancy. FERTIL STERIL 2009;92 (5):1659-1665 [PubMed]
Sadri-Ardekani H, Mizrak SC, van Daalen SKM, Korver CM, Roepers-Gajadien HL, Koruji M, Hovingh S, de Reijke TM, de La Rosette JJMCH, van der Veen F, de Rooij DG, Repping S, van Pelt AMM, Propagation of Human Spermatogonial Stem Cells In Vitro. JAMA-J AM MED ASSOC 2009;302 (19):2127-2134 [PubMed]
Stax MJ, van Montfort T, Sprenger RR, Melchers M, Sanders RW, van Leeuwen E, Repping S, Pollakis G, Speijer D, Paxton WA, Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes. VIROLOGY 2009;391 (2):203-211 [PubMed]
van Leeuwen E. Male reproduction and HIV-1 infection. s.l.: s.n.; 2009. 182p. ISBN 9789064643262 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Reiss P; copromotor(s): Prins JM, Repping S)
van Leeuwen E, Repping S, Prins JM, Reiss P, van der Veen F, Assisted reproductive technologies to establish pregnancies in couples with an HIV-1-infected man. NETH J MED 2009;67 (8):322-327 [PubMed]
Visser L, Westerveld GH, Korver CM, van Daalen SKM, Hovingh SE, Rozen S, van der Veen F, Repping S, Y chromosome gr/gr deletions are a risk factor for low semen quality. HUM REPROD 2009;24 (10):2667-2673 [PubMed]
de Rooij DG, Repping S, van Pelt AMM, Role for Adhesion Molecules in the Spermatogonial Stem Cell Niche. CELL STEM CELL 2008;3 (5):467-468 [PubMed]
Goddijn M, Repping SR, van der Veen F, Leschot NJ, Voorbeelden van pre-implantatie- genetische diagnostiek versus prenatale diagnostiek bij dragerschap van genetische afwijkingen: voor--en nadelen. NED TIJDSCHR GENEESKD 2008;152 (27):1545-6; author reply 1546 [PubMed]
Harper JC, de Die-Smulders C, Goossens V, Harton G, Moutou C, Repping S, Scriven PN, SenGupta S, Traeger-Synodinos J, van Rij MC, Viville S, Wilton L, Sermon KD, ESHRE PGD consortium data collection VII: cycles from January to December 2004 with pregnancy follow-up to October 2005. HUM REPROD 2008;23 (4):741-755 [PubMed]
Mastenbroek S, Scriven P, Twisk M, Viville S, van der Veen F, Repping S, What next for preimplantation genetic screening? More randomized controlled trials needed?. HUM REPROD 2008;23 (12):2626-2628 [PubMed]
Mastenbroek S, Twisk M, van der Veen F, Repping S, Preimplantation genetic screening. REPROD BIOMED ONLINE 2008;17 (2):293; author reply 294-293; author reply 295 [PubMed]
Musters AM, Goddijn M, Korevaar JC, van der Veen F, Mastenbroek S, Repping S, Benefits of PGD in patients with recurrent miscarriages?. FERTIL STERIL 2008;90 (1):240-241 [PubMed]
Musters AM, Oosterwijk C, Repping S, Twisk M, Goddijn M, Korevaar JC, van der Veen F, Leschot NJ, Doelgroep is onwetend. MED CONTACT 2008;63 (23):978-983
Shapiro BS. Optimal blastocyst transfer: the embryo and the endometrium. s.l.: s.n.; 2008. 188p. ISBN 9789071382581 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F; copromotor(s): Repping S)
Twisk M, Mastenbroek S, Hoek A, Heineman MJ, van der Veen F, Bossuyt PM, Repping S, Korevaar JC, No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy. HUM REPROD 2008;23 (12):2813-2817 [PubMed]
van Leeuwen E, Wit FW, Prins JM, Reiss P, van der Veen F, Repping S, Semen quality remains stable during 96 weeks of untreated human immunodeficiency virus-1 infection. FERTIL STERIL 2008;90 (3):636-641 [PubMed]
van Leeuwen E, Wit FW, Repping S, Eeftinck Schattenkerk JKM, Reiss P, van der Veen F, Prins JM, Effects of antiretroviral therapy on semen quality. AIDS 2008;22 (5):637-642 [PubMed]
van Weert JM, Repping S, van der Steeg JW, Steures P, van der Veen F, Mol BW, A prediction model for ongoing pregnancy after in vitro fertilization in couples with male subfertility. J REPROD MED 2008;53 (4):250-256 [PubMed]
Westerveld GH. Unraveling the genetics of spermatogenic failure. s.l.: s.n.; 2008. 128p. ISBN 9789064642951 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Leschot NJ; copromotor(s): Repping S, Lombardi MP)
Westerveld GH, Kaaij-Visser L, Tanck M, van der Veen F, Repping S, CAG repeat length variation in the polymerase gamma (POLG) gene: effect on semen quality. MOL HUM REPROD 2008;14 (4):245-249 [PubMed]
Westerveld H, Visser L, Tanck M, van der Veen F, Repping S, CAG repeat length variation in the Androgen Receptor gene is not associated with spermatogenic failure. FERTIL STERIL 2008;89 (1):253-259 [PubMed]
Lowe SH, van Leeuwen E, Droste JAH, van der Veen F, Reiss P, Lange JMA, Burger DM, Repping S, Prins JM, Semen quality and drug concentrations in seminal plasma of patients using a didanosine or didanosine plus tenofovir containing antiretroviral regimen. THER DRUG MONIT 2007;29 (5):566-570 [PubMed]
Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, Vogel NEA, Arts EGJM, de Vries JWA, Bossuyt PM, Buys CHCM, Heineman MJ, Repping S, van der Veen F, In vitro fertilization with preimplantation genetic screening. NEW ENGL J MED 2007;357 (1):9-17 [PubMed]
Mastenbroek S, van der Veen F, Repping S, In vitro fertilization with preimplantation genetic screening - Reply. NEW ENGL J MED 2007;357 (17):1770-1771
Sermon KD, Michiels A, Harton G, Moutou C, Repping S, Scriven PN, SenGupta S, Traeger-Synodinos J, Vesela K, Viville S, Wilton L, Harper JC, ESHRE PGD Consortium data collection VI: cycles from January to December 2003 with pregnancy follow-up to October 2004. HUM REPROD 2007;22 (2):323-336 [PubMed]
Twisk M, Haadsma ML, van der Veen F, Repping S, Mastenbroek S, Heineman MJ, Bossuyt PMM, Korevaar JC, Preimplantation genetic screening as an alternative to prenatal testing for Down syndrome: preferences of women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment. FERTIL STERIL 2007;88 (4):804-810 [PubMed]
Twisk M, van der Veen F, Repping S, Heineman MJ, Korevaar JC, Bossuyt PMM, Preferences of subfertile women regarding elective single embryo transfer: additional in vitro fertilization cycles are acceptable, lower pregnancy rates are not. FERTIL STERIL 2007;88 (4):1006-1009 [PubMed]
van den Berg H, Repping S, van der Veen F, Parental desire and acceptability of spermatogonial stem cell cryopreservation in boys with cancer. HUM REPROD 2007;22 (2):594-597 [PubMed]
van Leeuwen E, Prins JM, Jurriaans S, Boer K, Reiss P, Repping S, van der Veen F, Reproduction and fertility in human immunodeficiency virus type-1 infection. HUM REPROD UPDATE 2007;13 (2):197-206 [PubMed]
van Leeuwen E, ter Heine R, van der Veen F, Repping S, Beijnen JH, Prins JM, Penetration of atazanavir in seminal plasma of men infected with human immunodeficiency virus type 1. ANTIMICROB AGENTS CH 2007;51 (1):335-337 [PubMed]
Harper JC, Boelaert K, Geraedts J, Harton G, Kearns WG, Moutou C, Muntjewerff N, Repping S, SenGupta S, Scriven PN, Traeger-Synodinos J, Vesela K, Wilton L, Sermon KD, ESHRE PGD Consortium data collection V: Cycles from January to December 2002 with pregnancy follow-up to October 2003. HUM REPROD 2006;21 (1):3-21 [PubMed]
Mastenbroek S, Goddijn M, van der Veen F, Repping S, Bossuyt PMM, Korevaar JC, Twisk M, Heineman MJ, PGD--a model to evaluate efficacy?. FERTIL STERIL 2006;85 (2):534-5; author reply 535-6 [PubMed]
Noordam MJ, Repping S, The human Y chromosome: a masculine chromosome. CURR OPIN GENET DEV 2006;16 (3):225-232 [PubMed]
Noordam MJ, van der Veen F, Repping S, Techniques and reasons to remain interested in the Y chromosome. FERTIL STERIL 2006;86 (6):1801-2; author reply 1802-3 [PubMed]
Repping S, Geraedts J, Scriven P, Harton G, Veselá K, Kearns W, Viville S, Sermon K, Central data collection on PGD and screening. REPROD BIOMED ONLINE 2006;12 (3):389; author reply 390 [PubMed]
Repping S, van Daalen SKM, Brown LG, Korver CM, Lange J, Marszalek JD, Pyntikova T, van der Veen F, Skaletsky H, Page DC, Rozen S, High mutation rates have driven extensive structural polymorphism among human Y chromosomes. NAT GENET 2006;38 (4):463-467 [PubMed]
Twisk M, Mastenbroek S, van Wely M, Heineman MJ, van der Veen F, Repping S, Preimplantation genetic screening for abnormal number of chromosomes (aneuploidies) in in vitro fertilisation or intracytoplasmic sperm injection. COCHRANE DB SYST REV 2006;2006 (1):CD005291 [PubMed]
Westerveld GH, Korver CM, van Pelt AMM, Leschot NJ, van der Veen F, Repping S, Lombardi MP, Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. HUM REPROD 2006;21 (12):3178-3184 [PubMed]
Goddijn M, van Stralen M, Schuring-Blom H, Redeker B, van Leeuwen L, Repping S, Leschot N, van der Veen F, Detection of chromosome abnormalities by quantitative fluorescent PCR in ectopic pregnancies. GYNECOL OBSTET INVES 2005;60 (3):139-144 [PubMed]
Mastenbroek S, M M Bossuyt P, Heineman MJ, Repping S, van der Veen F, Comment 1 on Staessen et al. (2004). Design and analysis of a randomized controlled trial studying preimplantation genetic screening. HUM REPROD 2005;20 (8):2362-2363 [PubMed]
Twisk M, Mastenbroek S, Bossuyt PMM, Korevaar JC, Heineman MJ, Repping S, van der Veen F, The effectiveness of preimplantation genetic screening. REPROD BIOMED ONLINE 2005;11 (4):519-520 [PubMed]
van Leeuwen E, de Vries JWA, Jurriaans S, Verhoeve HR, Prins JM, Repping S, van der Veen F, Intra-uteriene inseminatie met bewerkt sperma bij HIV-serodiscordante paren met een HIV-positieve man. NED TIJDSCHR GENEESKD 2005;149 (8):423-424 [PubMed]
van Leeuwen E, van Weert JM, van der Veen F, Repping S, The effects of the human immunodeficiency virus on semen parameters and intrauterine insemination outcome. HUM REPROD 2005;20 (7):2033-2034 [PubMed]
van Weert JM, Repping S, van der Steeg JW, Steures P, van der Veen F, Mol BWJ, IUI in male subfertility: are we able to select the proper patients?. REPROD BIOMED ONLINE 2005;11 (5):624-631 [PubMed]
Westerveld GH, Repping S, Leschot NJ, van der Veen F, Lombardi MP, Mutations in the human BOULE gene are not a major cause of impaired spermatogenesis. FERTIL STERIL 2005;83 (2):513-515 [PubMed]
Westerveld GH, Repping S, Lombardi MP, van der Veen F, Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia. MOL HUM REPROD 2005;11 (9):673-675 [PubMed]
Lowe SH, Sankatsing SUC, Repping S, van der Veen F, Reiss P, Lange JMA, Prins JM, Is the male genital tract really a sanctuary site for HIV? Arguments that it is not. AIDS 2004;18 (10):1353-1362 [PubMed]
Mastenbroek S, Engel C, van Echten-Arends J, Sikkema-Raddatz B, van Wassenaer AG, de Vries JWA, Heineman MJ, Repping S, van der Veen F, Preimplantatiegenetische screening op numerieke chromosoomafwijkingen bij embryo's van vrouwen van 35 jaar en ouder; de eerste resultaten in Nederland. NED TIJDSCHR GENEESKD 2004;148 (50):2486-2490 [PubMed]
Repping S, Korver CM, Oates RD, Silber S, van der Veen F, Page DC, Rozen S, Are sequence family variants useful for identifying deletions in the human Y chromosome?. AM J HUM GENET 2004;75 (3):514-517 [PubMed]
Repping S, van Daalen SKM, Korver CM, Brown LG, Marszalek JD, Gianotten J, Oates RD, Silber S, van der Veen F, Page DC, Rozen S, A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. GENOMICS 2004;83 (6):1046-1052 [PubMed]
van Leeuwen E, Cornelissen M, de Vries JW, Lowe SH, Jurriaans S, Repping S, van der Veen F, Semen parameters of a semen donor before and after infection with human immunodeficiency virus type 1: Case report. HUM REPROD 2004;19 (12):2845-2848 [PubMed]
van Weert JM, Repping S, van Voorhis BJ, van der Veen F, Bossuyt PMM, Mol BWJ, Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: a meta-analysis. FERTIL STERIL 2004;82 (3):612-620 [PubMed]
Westerveld GH, Gianotten J, Leschot NJ, van der Veen F, Repping S, Lombardi MP, Heterogeneous nuclear ribonucleoprotein G-T (HNRNP G-T) mutations in men with impaired spermatogenesis. MOL HUM REPROD 2004;10 (4):265-269 [PubMed]
Pannekoek Y, Westenberg SM, Eijk PP, Repping S, van der Veen F, van der Ende A, Dankert J, Assessment of Chlamydia trachomatis infection of semen specimens by ligase chain reaction. J MED MICROBIOL 2003;52 (Part 9):777-779 [PubMed]
Repping S. Reproductive fitness of the human Y chromosome. Amsterdam: s.n.; 2003. 186p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Leschot NJ; copromotor(s): Page DC, Rozen S)
Repping S, de Vries JWA, van Daalen SKM, Korver CM, Leschot NJ, van der Veen F, The use of spermHALO-FISH to determine DAZ gene copy number. MOL HUM REPROD 2003;9 (4):183-188 [PubMed]
Repping S, Skaletsky H, Brown L, van Daalen SKM, Korver CM, Pyntikova T, Kuroda-Kawaguchi T, de Vries JWA, Oates RD, Silber S, van der Veen F, Page DC, Rozen S, Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection. NAT GENET 2003;35 (3):247-251 [PubMed]
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC, The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. NATURE 2003;423 (6942):825-U2 [PubMed]
de Vries JWA, Hoffer MJV, Repping S, Hoovers JMN, Leschot NJ, van der Veen F, Reduced copy number of DAZ genes in subfertile and infertile men. FERTIL STERIL 2002;77 (1):68-75 [PubMed]
de Vries JWA, Repping S, van Daalen SKM, Korver CM, Leschot NJ, van der Veen F, Clinical relevance of partial AZFc deletions. FERTIL STERIL 2002;78 (6):1209-1214 [PubMed]
Repping S, Skaletsky H, Lange J, Silber S, van der Veen F, Oates RD, Page DC, Rozen S, Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure. AM J HUM GENET 2002;71 (4):906-922 [PubMed]
Repping S, van Weert JM, Mol BWJ, de Vries JWA, van der Veen F, Use of the total motile sperm count to predict total fertilization failure in in vitro fertilization. FERTIL STERIL 2002;78 (1):22-28 [PubMed]
Silber SJ, Repping S, Transmission of male infertility to future generations: lessons from the Y chromosome. HUM REPROD UPDATE 2002;8 (3):217-229 [PubMed]
van Leeuwen L, de Vries J, Repping S, Boer K, van der Veen F, Kunstmatige voortplantingstechnieken bij HIV serodiscordante koppels. NATEC NIEUWSBULLETIN 2002;dec.:5-7
van Praag RME, Repping S, de Vries JWA, Lange JMA, Hoetelmans RMW, Prins JM, Pharmacokinetic profiles of nevirapine and indinavir in various fractions of seminal plasma (vol 45, pg 2902, 2001). ANTIMICROB AGENTS CH 2002;46 (3):941
de Vries JW, Repping S, Oates R, Carson R, Leschot NJ, van der Veen F, Absence of deleted in azoospermia (DAZ) genes in spermatozoa of infertile men with somatic DAZ deletions. FERTIL STERIL 2001;75 (3):476-479 [PubMed]
van Praag RM, Repping S, de Vries JW, Lange JM, Hoetelmans RM, Prins JM, Pharmacokinetic profiles of nevirapine and indinavir in various fractions of seminal plasma. ANTIMICROB AGENTS CH 2001;45 (10):2902-2907 [PubMed]
Clark DR, Repping S, Pakker NG, Prins JM, Notermans DW, Wit FW, Reiss P, Danner SA, Coutinho RA, Lange JM, Miedema F, T-cell progenitor function during progressive human immunodeficiency virus-1 infection and after antiretroviral therapy. BLOOD 2000;96 (1):242-249 [PubMed]
Pannekoek Y, Westenberg SM, de Vries J, Repping S, Spanjaard L, Eijk PP, van der Ende A, Dankert J, PCR assessment of Chlamydia trachomatis infection of semen specimens processed for artificial insemination. J CLIN MICROBIOL 2000;38 (10):3763-3767 [PubMed]
Saxena R, de Vries JW, Repping S, Alagappan RK, Skaletsky H, Brown LG, Ma P, Chen E, Hoovers JM, Page DC, Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. GENOMICS 2000;67 (3):256-267 [PubMed]
Nielsen SD, Clark DR, Hutchings M, Dam-Larsen S, Repping S, Nielsen JO, Mathiesen L, Miedema F, Hansen JE, Treatment with granulocyte colony-stimulating factor decreases the capacity of hematopoietic progenitor cells for generation of lymphocytes in human immunodeficiency virus-infected persons. J INFECT DIS 1999;180 (6):1819-1826 [PubMed]
Key publications

Sadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AMM, In Vitro Propagation of Human Prepubertal Spermatogonial Stem Cells. JAMA-J AM MED ASSOC 2011;305 (23):2416-2418 [PubMed]
Sadri-Ardekani H, Mizrak SC, van Daalen SKM, Korver CM, Roepers-Gajadien HL, Koruji M, Hovingh S, de Reijke TM, de La Rosette JJMCH, van der Veen F, de Rooij DG, Repping S, van Pelt AMM, Propagation of Human Spermatogonial Stem Cells In Vitro. JAMA-J AM MED ASSOC 2009;302 (19):2127-2134 [PubMed]
Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, Vogel NEA, Arts EGJM, de Vries JWA, Bossuyt PM, Buys CHCM, Heineman MJ, Repping S, van der Veen F, In vitro fertilization with preimplantation genetic screening. NEW ENGL J MED 2007;357 (1):9-17 [PubMed]
van Echten-Arends J, Mastenbroek S, Sikkema-Raddatz B, Korevaar JC, Heineman MJ, van der Veen F, Repping S, Chromosomal mosaicism in human preimplantation embryos: a systematic review. HUM REPROD UPDATE 2011;17 (5):620-627 [PubMed]
Hughes JF, Skaletsky H, Pyntikova T, Graves TA, van Daalen SKM, Minx PJ, Fulton RS, McGrath SD, Locke DP, Friedman C, Trask BJ, Mardis ER, Warren WC, Repping S, Rozen S, Wilson RK, Page DC, Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content. NATURE 2010;463 (7280):536-539 [PubMed]


All Publications

Curriculum Vitae

Personal details
Name: Sjoerd Repping, PhD
Title: Professor Human Reproductive Biology
Sex: Male
Date of birth: 19 November 1974
Place of birth: Nijmegen
Nationality: Dutch
Marital status: married, 3 children

 

A. Positions and Honors:
I. Positions and Employment
2016 –           Program Director, Research Theme Reproduction & Development, AMC/VUmc
2013 -            Head of the Center for Reprouctive Medicine, AMC, University of Amsterdam
2009 –           Professor of Human Reproductive Biology, AMC, University of Amsterdam.
2007 –           Principal Investigator, Department of Obstetrics and Gynecology, AMC, University of Amsterdam.
2005 – 2013 Director of the Fertility Laboratory, Center for Reproductive Medicine, AMC, UvA.
2004 – 2009 Visiting scientist, Page Lab, Whitehead Institute, Cambridge, U.S.A.
2005 – 2009 Associate professor, clinical embryologist, Center for Reproductive Medicine, AMC, UvA.
2003 – 2005 Assistant professor, clinical embryologist, Center for Reproductive Medicine, AMC, UvA.
2002 – 2003 Clinical embryologist, research scientist, Center for Reproductive Medicine, AMC, UvA.
2001 – 2001 Visiting graduate student, Page Lab, Whitehead Institute, Cambridge, U.S.A.
1998 – 2002 Clinical embryologist in training, Center for Reproductive Medicine, AMC, UvA.

 

II. Other Experience and Professional Memberships
2015 -           
Advisory committee member for the National Health Council on biotechnological developments
2013 -           Chair of the AMC Environmental Advisory Platform
2013 –          Member of the Central Committee on Research Involving Human Subjects (CCMO)
2012             Member of the ESHRE expert group on Epigenetic and Health effects of ART
2010 –          Chair of the Dutch Society for Clinical Embryology (KLEM)
2010 –          Board member, Dutch Society for Reproductive Medicine
2012 – 2014 Associate Editor Molecular Human Reproduction
2009 – 2011 National Representative of ESHRE for the Netherlands
2009 – 2011 Deputy of the SIG Reproductive Genetics of ESHRE
2009 – 2010 Chair of the workgroup semenanalysis
2009             Member of the local organizing committee of ESHRE Amsterdam
2007 – 2011 Member of the ESHRE PGS Task force
2007 – 2008 Chair of the workgroup on PGS of the ESHRE PGD Consortium
2007             Chair of the advisory board on vitrification
2007             Member of the advisory board on in vitro maturation
2006 – 2011 Chair of the science committee of the KLEM
2005 – 2006 Member of the advisory committee of the board of the AMC on science policy
2005 –           Member of the Research Counsel of the Department of Obstetrics and Gynecology (AMC)
2004 – 2008 Member of the Steering Committee of the ESHRE PGD Consortium
2004 –          Chair of the workgroup on Reproductive Genetics
2003              Member of the organizing committee of the Reinier de Graaff symposium
2001 –           Member of the American Society of Human Genetics (ASHG)
2001 –           Member of the American Society for Reproductive Medicine
1998 –           Member of the European Society of Human Reproduction and Embryology (ESHRE)

 

III. Honors and Awards
2013 Elected member of The Young Academy of The Royal Netherlands Academy of Arts and Sciences
2011 Tom Voute Award for outstanding research in childhood cancer (Kika)
2009 One of the ten most promising Dutch individuals for the years 2010-2020 (NRC Handelsblad)
2008 VIDI grant for established young researchers
2004 VENI grant for talented young researchers
2004 AMC Young Investigator Publication Award
2003 Cotterman award of the American Society of Human Genetics
2003 Jan Swammerdam prize
2003 Research Institute Gene-expression Endocrinology Metabolism and Oncology (GEMO) prize
2001 Society of Male Reproduction and Urology prize-paper, American Society for Reproductive Medicine
2000 Vereniging voor Fertiliteits Studie (VFS) prize

 

B. Selection of peer-reviewed publications and patents:
I. Your ten most contributing (most significant) publications
- Sadri-Ardekani, H., Akhondi, M.A., van der Veen, F., Repping, S., van Pelt, A.M. (2011) JAMA 305(23):2416-8
- Hughes, J.F., Skaletsky, H., Pyntikova, T., Graves, T.A., van Daalen, S.K., Minx, P.J., Fulton, R.S., McGrath, S.D., Locke, D.P., Friedman, C., Trask, B.J., Mardis, E.R., Warren, W.C., Repping, S., Rozen, S., Wilson, R.K., Page, D.C. (2010) Nature. 463(7280):539-9
- Sadri-Ardekani, H., Mizrak, S.C., van Daalen, S.K., Korver, C.M., Roepers-Gajadien, H.L., Koruji, M., Hovingh, S., de Reijke, T.M., de la Rosette, J.J., van der Veen, F., de Rooij, D.G., Repping, S., van Pelt, A.M. (2009) JAMA 302(19):2127-34.
- Lange, J., Skaletsky, H., van Daalen, S.K.M., Embry, S.L., Korver, C.M., Brown, L.G., Oates, R.D., Silber, S., Repping, S., Page D.C. (2009) Cell. 138(5):855-69.
- Mastenbroek, S., Twisk, M., van Echten-Arends, J., Sikkema-Raddatz, B., Korevaar, J.C., Verhoeve, H.R., Vogel, N.E., Arts, E.G., de Vries, J.W., Bossuyt, P.M., Buys, C.H., Heineman, M.J., Repping, S., van der Veen, F. (2007) N Engl J Med. 357(1):9-17.
- van Leeuwen, E., Prins, J.M., Jurriaans, S., Boer, K., Reiss, P., Repping, S., van der Veen, F. (2007) Hum Reprod Update. 13(2):197-206.
- Repping, S., van Daalen, S.K., Brown, L.G., Korver, C.M., Lange, J., Marszalek, J.D., Pyntikova, T., van der Veen, F., Skaletsky, H., Page, D.C., Rozen, S. (2006) Nat Genet, 38(4):463-467.
- Repping, S., Skaletsky, H., Brown, L.G., van Daalen, S.K., Korver, C.M., Pyntikova, T., Kuroda-Kawaguchi, T., de Vries, J.W., Oates, R.D., Silber, S., van der Veen, F., Page, D.C. and Rozen, S. (2003) Nat.Genet., 35(3): 247-251.
- Skaletsky, H., Kuroda-Kawaguchi, T., Minx, P. J., Cordum, H. S., Hillier, L., Brown, L. G., Repping, S., Pyntikova, T., Johar, A., Delehaunty, K. et al. (2003) Nature, 423(6942):825-837.
- Repping, S., Skaletsky, H., Lange, J., Silber, S., van der Veen, F., Oates, R. D., Page, D. C., and Rozen, S. (2002) Am.J.Hum.Genet., 71(4):906-922.

 

II. Median impact factor of your publications
I have (co-)authored 153 papers as listed in the Web of Science with an average of 22.12 citations per item.

 

III. Median impact factors for your own field(s)
OBSTETRICS & GYNECOLOGY Median Impact Factor 1.804, REPRODUCTIVE BIOLOGY Median Impact Factor 2.385

 

IV. The top 3 leading Journals in my field are
Human Reproduction Update, Human Reproduction, Fertility & Sterility

 

V. Patents
United States Patent Application 20090087855, Markers of alterations in the Y chromosome and uses therefor
INV-00463, Leydig Progenitor Cells, 2013

 

C. Research support
Ongoing research support
- ZonMw Translational Adult Stem Cell Research Grant, 01/01/2014 – 01/01/2022, Role: PI, Amount: 1645 k€
- ZonMw E&K (AID study), 01/01/2014 – 01/01/2017, Role: Co-PI, Amount: 300 k€
- The CoSy trial: Internet based Sex counseling and changes on natural conception in couples in couples with Idiopathic Subfertility (ZonMw, 2015-2018, co-applicant, 250 k) 
- Intrauterine insemination in unexplained or mild male subfertility (ZonMw, 2016-2019, co-applicant, 370 k)
- IVF for unexplained or mild male factor subfertility in women between 38 and 43 years of age (ZonMw 2014-2017, co-applicant, 370k)
- Kwaliteit van zorg binnen de NVOG (ZonMw, 2015-2016, PI, 150 k)
- Ontwikkeling van Behandelingskeuzehulpen om de Nederlandse fertiliteitszorg patiëntgerichter en betaalbaarder te maken door overbehandeling tegen te gaan
   (Innovatiefonds ZN, 2015-2016, co-applicant, 50k)
- Publieke opinie over de aanvaardbaarheid van artificiële gameten (KNAW, 2015-2016, PI, 8k)

 

 

 

 

Completed Research Support

- AMC fellowship grant to Geert Hamer, 01/01/2011 – 01/01/2016, Role: Host Laboratory, Amount: 700 k€
- AMC PhD scholarship to Kai Mee Wong, 06/01/2011 – 06/01/2015, Role: Host Laboratory, Amount: 210 k€
- VEMI grant (ZonMw, ENDORECEPT), 04/01/2011 – 04/01/2015, Role: PI, Amount: 125 k€
- VIDI grant (NWO), 04/01/2009 – 04/01/2015, Role: PI, Amount: 600 k€
- KiKa grant, 10/01/2011 – 10/01/2013, Role: co-PI, Amount: 585 k€
- AMC PhD grant to Eleni Mantikou, 06/01/2009 – 06/01/2013, Role: PI, Amount: 210 k€
- KiKa grant, Repping (PI), 09/01/2007 – 09/01/2011, Role: PI, Amount: 630 k€
- AIDS-fund (HIV-ICSI), Repping (PI), 07/01/2007 – 07/01/2009, Role: PI, Amount: 148 k€
- Wim Schellekens grant, 01/01/2004 – 01/01/2006, Role: Co-PI, Amount: 10 k€
- VENI grant (NWO), 01/01/2005 – 01/01/2009, Role: PI, Amount: 200 k€
- NIH/NHGRI/HG00257, 03/01/2003 – 02/28/2006, Role: Co-PI, Amount: 50 k€
- ZonMw grant (Follow-up), 01/01/2003 – 01/01/2008, Role: Co-PI, Amount: 100 k€
- ZonMw grant (PGS), 01/04/2002 – 01/04/2007, Role: Co-PI, Amount: 810 k€
- AIDS-fund (semen), 01/01/2002 – 01/01/2006, Role: Co-PI, Amount: 140 k€
- AMC guideline fund, 07/01/2002 – 07/01/2004, Role: Co-PI, Amount: 20 k€

 

Supervised PhD students
Completed
Bruce Shapiro defense 20081120 Co-promotor
Henrike Westerveld defense 20081211 Co-promotor
Liesbeth van Leeuwen defense 20090415 Co-promotor
Gianfranco Carlomagno defense 2011011 Promotor
Sebastiaan Mastenbroek 20111026 Promotor
Moniek Twisk 20111026 Co-promotor
Hooman Sadri Ardekani 20111222 Promotor
Anna Musters 20120111 Promotor
Janne-Meije van Weert 20120314 Co-promotor
Michiel Noordam 20120512 Promotor
Julia Chikhovskaya 20131113 Promotor
Laura van Loendersloot 20131203 Co-promotor 
Eleni Mantikou 20131203 Promotor
Liesbeth Visser 20141119 Promotor
Bita Nick Kholgh 20150612 Promotor
Emma Verver 20151001 Promotor
 

 

Ongoing
Sabrina Jan (2017)
Kai Mee Wong ((2017)
Maartje Cissen (2017)
Saskia Hendriks (2017)
Femke Kop (2017)
Callista Mulder (2017)
Martina Pontesilli (2018)
Robin Struijk (2017)
Majid Tarahomi (2017)
Marja Visser (2017)     
Yi Zheng (2017)
Joanna Diogo Portela (2018)
Ieva Masliukaite (2018)
Jitske Eliveld (2018)
Vera Manders (2018)
Robbert Berkhout (2018)
Noor Danhof (2019)

Felicia Dreischor (2020)

Jori Leijdekkers (2020)

Joana Serrano (2020)

Eva Balkenende (2018)

Jaime Onofre Meza (2019)

 

 

 

Research programmes

Reproduction & Development -- Human Reproduction

 Our research focusses on clinical and basic aspects of Human Reproductive Biology.

 See also: De Jonge Akademie (includes videos) and Nieuw leven in het lab : Geassisteerde voortplanting (video)

Faculty
Prof. dr. S. Repping
G.B. Afink PhD
Dr. I.M. Custers
Dr. E.A.F. Dancet
Dr. M. van DIjk
Prof. dr. M. Goddijn MD PhD
Dr. G. Hamer PhD
Dr. S. Mastenbroek PhD
Dr. M.H. Mochtar MD PhD
Dr. F. Mol MD
Dr. A.M.M. van Pelt PhD
Prof. dr. B. Reversade
Dr. C. Ris-Stalpers PhD
Prof. D.G. de Rooij
Prof. dr. F. van der Veen
Dr. M. van Wely

PhD Students
Drs. E.M.E. Balkenende MD
Drs. R.P. Berkhout MD
N.A. Danhof
F. Dreischor
J. Eliveld MSc
S. Hendriks
S.Z. Jan MSc
P.A.L. Kop MD
V.D. Manders
I. Masliukaite MSc
J.A. Meza
C.L. Mulder MSc
Drs. M. Pontesilli
J.M.D. Portela MSc
J.M. Serrano
M.A.J. Smits
R.B. Struijk MSc
M. Tarahomi MD
Drs. Y. Zheng

Others
S.K.M. van Daalen BSc
Ing. R. Keijser BSc
C.M. Korver BSc
Ing. G.J.M. Veenboer
T.S. de Vries

Prof. dr. F. van der Veen (Reproduction and development])

Other research related activities
  • None reported
Current research funding
  • AMC
  • Ferring Research Institute Inc.
  • Ned. Vereniging voor Obstetrie en Gynaecologie (NVOG)
  • Technologiestichting STW
  • Universiteit van Amsterdam-ABC
  • ZonMw