• Principal Investigator
  • Male

Prof. dr. M. Boele van Hensbroek MD PhD

Position: Professor
Main activities: Patient care, Research, Teaching
Specialisation: Global Child Health, Paediatric Infectious Diseases
foto M. Boele van Hensbroek is one of the AMC Principal Investigators
Focus of research:
  1. Research Capacity building in developing countries (DC) through the development of a network of Research Support Centre's
  2. Malaria in children
  3. Severe anaemia in children in DC
  4. HIV in children in DC
  5. Managenet of critically ill children in DC
AMC themes: Infection & Immunity, Public Health & Epidemiology
Departments: Global Health, Paediatrics: Haematology / Immunology / Infectious Diseases
Bartels RH, Bourdon C, Potani I, Mhango B, van den Brink DA, Mponda JS, Muller Kobold AC, Bandsma RH, Boele van Hensbroek M, Voskuijl WP, Pancreatic Enzyme Replacement Therapy in Children with Severe Acute Malnutrition: A Randomized Controlled Trial. J PEDIATR-US 2017;ahead of print [PubMed]
Bartels RH, van den Brink DA, Bandsma RH, Boele van Hensbroek M, Tabbers MM, Voskuijl WP, The Relation Between Malnutrition and the Exocrine Pancreas: A Systematic Review. J PEDIATR GASTR NUTR 2017;-:- [PubMed]
Boerma RS. Prevention, suppression, and resistance: Antiretroviral treatment for children with HIV in Sub-Saharan Africa. S.l.: s.n.; 2017. 256p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij AIGHD, -. (Promotor(s): Rinke de Wit TF, Boele van Hensbroek M; copromotor(s): Calis JCJ, Sigaloff KCE)
Boerma RS, Kityo C, Boender TS, Kaudha E, Kayiwa J, Musiime V, Mukuye A, Kiconco M, Nankya I, Nakatudde L, Mugyenyi PN, Boele van Hensbroek M, Rinke de Wit TF, Sigaloff KCE, Calis JCJ, Second-line HIV Treatment in Ugandan Children: Favorable Outcomes and No Protease Inhibitor Resistance. J TROP PEDIATRICS 2017;63 (2):135-143 [PubMed]
Boerma RS, Sigaloff KCE, Akanmu AS, Inzaule S, Boele van Hensbroek M , Rinke de Wit TF, Calis JC, Alarming increase in pretreatment HIV drug resistance in children living in sub-Saharan Africa: a systematic review and meta-analysis. J ANTIMICROB CHEMOTH 2017;72 (2):365-371 [PubMed]
Brals D, Aderibigbe SA, Wit FW, van Ophem JCM, van der List M, Osagbemi GK, Hendriks ME, Akande TM, Boele van Hensbroek M, Schultsz C, The effect of health insurance and health facility-upgrades on hospital deliveries in rural Nigeria: a controlled interrupted time-series study. HEALTH POLICY PLANN 2017;32 (7):990-1001 [PubMed]
Gathara D, Malla L, Ayieko P, Karuri S, Nyamai R, Irimu G, Boele van Hensbroek M, Allen E, English M [Contributors: Githanga D, Were F, Kigen B, NgarNgar S, Aduro N, Inginia R, Mutai B, Ochieng G, Thuranira L, Kanyingi F, Kuria M, Otido S, Rutha K, Njiiri P, Chabi M, Nzioki C, Ondere J, Emadau C, Mutiso C, Muinga N, Bitok M, Tuti T, Makone B, Nyachiro W, Mbevi G, Julius T, Gachau S, Ogero M]] , Variation in and risk factors for paediatric inpatient all-cause mortality in a low income setting: data from an emerging clinical information network. BMC PEDIATR 2017;17 (1):99 [PubMed]
Harris VC , Haak BW, Boele van Hensbroek M, Wiersinga WJ, The Intestinal Microbiome in Infectious Diseases: The Clinical Relevance of a Rapidly Emerging Field. OPEN FORUM INFECT DIS 2017;4 (3):ofx144 [PubMed]
Jonker FAM, te Poel E, Bates I, Boele van Hensbroek M, Anaemia, iron deficiency and susceptibility to infection in children in sub-Saharan Africa, guideline dilemmas. BRIT J HAEMATOL 2017;177 (6):878-883 [PubMed]
Kiemde F, Bonko MDA, Tahita MC, Lompo P, Rouamba T, Tinto H, Boele van Hensbroek M, Mens PF, Schallig HDFH, Accuracy of a Plasmodium falciparum specific histidine-rich protein 2 rapid diagnostic test in the context of the presence of non-malaria fevers, prior anti-malarial use and seasonal malaria transmission. MALARIA J 2017;16 (1):294 [PubMed]
Obonyo N, Brent B, Olupot-Olupot P, Boele van Hensbroek M, Kuipers I, Wong S, Shiino K, Chan J, Fraser J, van Woensel JBM, Maitland K, Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study). CRIT CARE 2017;21 (1):103 [PubMed]
Rashid ANS, Boele van Hensbroek M, Kolader M, Hovius JW, Pajkrt D, Lyme Borreliosis in Children: A Tertiary Referral Hospital Based Retrospective Analysis. PEDIATR INFECT DIS J 2017;-:- [PubMed]
Thielemans L, Trip-Hoving M, Bancone G, Turner C, Simpson JA, Hanboonkunupakarn B, van Hensbroek MB, van Rheenen P, Paw MK, Nosten F, McGready R, Carrara VI, Neonatal Hyperbilirubinemia in a Marginalized Population on the Thai-Myanmar Border: a study protocol. BMC PEDIATR 2017;17 (1):32 [PubMed]
van Keulen V, Huibers M, Manshande M, Boele van Hensbroek M, van Rooij L, Chikungunya Virus Infections Among Infants - WHO Classification not Applicable. PEDIATR INFECT DIS J 2017;-:- [PubMed]
Boele van Hensbroek M, van Furth M, Improving Global Child Health in the Light of the (Old) Millennium Development Goals and the (New) Sustainable Development Goals. PEDIATR INFECT DIS J 2016;35 (8):918-919 [PubMed]
Boender S. Long-term effects of HIV treatment in sub-Saharan Africa: from access to quality. S.l.: s.n.; 2016. 265p. ISBN 978-94-6169-841-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Rinke de Wit TF, Boele van Hensbroek M; copromotor(s): Sigaloff KCE, Calis JCJ)
Boerma RS, Boender TS, Bussink AP, Calis JCJ, Bertagnolio S, Rinke de Wit TF, Boele van Hensbroek M, Sigaloff KCE, Suboptimal Viral Suppression Rates Among HIV-Infected Children in Low- and Middle-Income Countries: A Meta-analysis. CLIN INFECT DIS 2016;63 (12):1645-1654 [PubMed]
Boerma RS, Boender TS, Sigaloff KCE, Rinke de Wit TF, van Hensbroek MB, Ndembi N, Adeyemo T, Temiye EO, Osibogun A, Ondoa P, Calis JC, Akanmu AS, High levels of pre-treatment HIV drug resistance and treatment failure in Nigerian children. J INT AIDS SOC 2016;19 (1):21140 [PubMed]
Calis JCJ, Phiri KS, Faragher EB, Brabin BJ, Bates I, Cuevas LE, de Haan RJ, Phiri AI, Malange P, Khoka M, Hulshof PJM, van Lieshout L, Beld MGHM, teo YY, Rockett KA, Richardson A, Kwiatkowski DP, Molyneux ME, Boele van Hensbroek M, Severe anemia in Malawian children. MALAWI MED J 2016;28 (3):99-107 [PubMed]
Huibers MHW, Moons P, Maseko N, Gushu MB, Wit FW, Graham SM, van Hensbroek MB, Calis JC, An Evaluation of Alternative Markers to Guide Initiation of Anti-retroviral Therapy in HIV-Infected Children in Settings where CD4 Assays are not Available. J TROP PEDIATRICS 2016;62 (1):19-28 [PubMed]
Boele van Hensbroek M , Goyens P, van Rheenen PF. Tropische kindergneeskunde in: Heymans HSA, Derksen-Lubsen A, Draaisma JMT, van Goudoever JB, Nieuwenhuis EES, editors. Leerboek Kindergeneeskunde, 2e geheel herz. dr. S.l.: s.n.; 2015., p. 879-894
Boerma RS, Boender TS, Boele van Hensbroek M, Rinke de Wit TF, Sigaloff KCE, Sequencing paediatric antiretroviral therapy in the context of a public health approach. J INT AIDS SOC 2015;18 (6):24-29 [PubMed]
Boerma RS, Wit FWNM, Orock SO, Schonenberg-Meinema D, Hartdorff CM, Bakia A, van Hensbroek MB, Mortality risk factors among HIV-exposed infants in rural and urban Cameroon. TROP MED INT HEALTH 2015;20 (2):170-176 [PubMed]
Gathara D, English M, van Hensbroek MB, Todd J, Allen E, Exploring sources of variability in adherence to guidelines across hospitals in low-income settings: a multi-level analysis of a cross-sectional survey of 22 hospitals. IMPLEMENT SCI 2015;10 (1):60 [PubMed]
Gathara DN. The use of routine case record data to evaluate quality of inpatient hospital care for newborns and children in Kenya. S.l.: s.n.; 2015. 143p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij KEMRI-Wellcome Trust Research Programme Nairobi, Kenya, -. (Promotor(s): Boele van Hensbroek M , English M; copromotor(s): )
Gomez GB, Foster N, Brals D, Nelissen HE, Bolarinwa OA, Hendriks ME, Boers AC, van Eck D, Rosendaal N, Adenusi P, Agbede K, Akande TM, Boele van Hensbroek M, Wit FW, Hankins CA, Schultsz C, Improving Maternal Care through a State-Wide Health Insurance Program: A Cost and Cost-Effectiveness Study in Rural Nigeria. PLOS ONE 2015;10 (9):e0139048 [PubMed]
Green HK. Assessing the epidemiological impact of extending the national influenza vaccination programme to healthy children in England. S.l.: s.n.; 2015. 179p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Centre for Infectious Disease Surveillance and Control, Public Health England, London, Department of Respiratory Diseases. (Promotor(s): Pebody RG, Boele van Hensbroek M; copromotor(s): Andrews N, Baguelin M)
López Bustinduy A. The burden of schistosomiasis morbidity in African children: validating novel, low-cost and scalable detection tools and optimizing praziquantel treatment. S.l.: s.n.; 2015. 228p. ISBN 978-94-6259-658-0 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Liverpool School of Tropical Medicine, Department of Parasitology. (Promotor(s): Boele van Hensbroek M; copromotor(s): King CH, Strothard JR)
Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B, M'baya B, Bates I, Urban B, Boele van Hensbroek M, Heyderman R, Thomason MJ, Uyoga S, Williams TN, Gibb DM, George EC, Walker AS, Maitland K, Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial. TRIALS 2015;16 (1):593 [PubMed]
Mwaniki MK. Burden and outcome of neonatal diseases and conditions at a rural district hospital setting in Kenya. S.l.: s.n.; 2015. 216p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Kenya Medical Research Institute, Centre for Geographic Medicine Research. (Promotor(s): Boele van Hensbroek M, Newton CRJC; copromotor(s): Kager PA)
Hill JA. Systematic assessment of factors affecting the delivery, access and use of interventions to control malaria in pregnancy in sub-Saharan Africa. S.l.: s.n.; 2014. 324p. ISBN 9789036104074 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Liverpool School of Tropical Medicine, Clinical science. (Promotor(s): ter Kuile FO, Boele van Hensbroek M; copromotor(s): Webster J)
Jonker FAM, Boele van Hensbroek M, Anaemia, iron deficiency and susceptibility to infections. J INFECTION 2014;69 (Suppl. 1):S23-S27 [PubMed]
Jonker FAM, Boele van Hensbroek M, Leenstra T, Vet RJWM, Brabin BJ, Maseko N, Gushu MB, Emana M, Kraaijenhagen R, Tjalsma H, Swinkels DW, Calis JCJ, Conventional and novel peripheral blood iron markers compared against bone marrow in Malawian children. J CLIN PATHOL 2014;67 (8):717-723 [PubMed]
Kyeyune FX, Calis JCJ, Phiri KS, Faragher B, Kachala D, Brabin BJ, Boele van Hensbroek M, The interaction between malaria and human immunodeficiency virus infection in severely anaemic Malawian children: a prospective longitudinal study. TROP MED INT HEALTH 2014;19 (6):698-705 [PubMed]
Boele van Hensbroek M. Cultuur en onderzoekscapaciteit in Afrika in: Heymans H, Derksen-Lubsen A, editors. Kindergeneeskunde in een wereld van verschil. Utrecht: Tijdstroom; 2013., p. 33
Esan MO, van Hensbroek MB, Nkhoma E, Musicha C, White SA, ter Kuile FO, Phiri KS, Iron supplementation in HIV-infected Malawian children with anemia: a double-blind, randomized, controlled trial. CLIN INFECT DIS 2013;57 (11):1626-1634 [PubMed]
Hulleman M, Boele van Hensbroek M. Malaria in: van Furth AM, Ang CW, Bredius RGM, van der Kuip M, Warris A, Wolfs TFW, Kneepkens CMF, editors. Infectieziekten en afweerstoornissen bij kinderen. S.l.: s.n.; 2013., p. 115-121
Jonker FAM, Calis JCJ, Phiri K, Kraaijenhagen RJ, Brabin BJ, Faragher B, Wiegerinck ET, Tjalsma H, Swinkels DW, van Hensbroek MB, Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiency. PLOS ONE 2013;8 (12):e78964 [PubMed]
Pakker N, Gomo E, Kyamanywa P, Mandala W, Katabira E, Klatser P, Boele van Hensbroek M, Research capacity development for Africa: Consolidation, Ownership and Independence.. MT BULL NETH SOC TROP MED INT HEALTH 2013;51:4
Dekker LH, Fijnvandraat K, Brabin BJ, van Hensbroek MB, Micronutrients and sickle cell disease, effects on growth, infection and vaso-occlusive crisis: A systematic review. PEDIATR BLOOD CANCER 2012;59 (2):211-215 [PubMed]
Esan MO. Interventions for anaemia in children living in a resource-poor setting: Malawi. s.l.: s.n.; 2012. 153p. ISBN 978903613305 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Brabin BJ; copromotor(s): Phiri KS, Boele van Hensbroek M)
Esan MO, Jonker FAM, Hensbroek MBv, Calis JCJ, Phiri KS, Iron deficiency in children with HIV-associated anaemia: a systematic review and meta-analysis. T ROY SOC TROP MED H 2012;106 (10):579-587 [PubMed]
Jonker FAM. Anaemia, iron deficiency and infections. New perceptions of the interaction between hepcidin, iron biomarkers, anaemia and inflammation in Malawian children. s.l.: s.n.; 2012. 144p. ISBN 9789491456213 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Brabin BJ; copromotor(s): Boele van Hensbroek M , Calis JCJ)
Jonker FAM, Calis JCJ, Boele van Hensbroek M, Phiri K, Geskus RB, Brabin BJ, Leenstra T, Iron Status Predicts Malaria Risk in Malawian Preschool Children. PLOS ONE 2012;7 (8):e42670 [PubMed]
Jonker FAM, Calis JCJ, Phiri K, Brienen EAT, Khoffi H, Brabin BJ, Verweij JJ, van Hensbroek MB, van Lieshout L, Real-time PCR Demonstrates Ancylostoma duodenale Is a Key Factor in the Etiology of Severe Anemia and Iron Deficiency in Malawian Pre-school Children. PLOS NEGLECT TROP D 2012;6 (3):e1555 [PubMed]
Phiri K, Esan M, Boele van Hensbroek M, Khairallah C, Faragher B, ter Kuile FO, Effect of intermittent preventative therapy for secondary prevention of severe malarial anaemia reply. LANCET INFECT DIS 2012;12 (12):906-907 [PubMed]
Phiri K, Esan M, van Hensbroek MB, Khairallah C, Faragher B, ter Kuile FO, Intermittent preventive therapy for malaria with monthly artemether-lumefantrine for the post-discharge management of severe anaemia in children aged 4-59 months in southern Malawi: a multicentre, randomised, placebo-controlled trial. LANCET INFECT DIS 2012;12 (3):191-200 [PubMed]
Esan MO, Phiri KS, Molyneux EM, Mukaka M, Cheema B, Boele van Hensbroek M, High transfusion failure rates in Malawian children with severe anaemia following a standard blood transfusion regimen. BRIT J HAEMATOL 2011;154 (6):783-785 [PubMed]
Gomo E, Kalilani L, Mwapasa V, Trigu C, Phiri K, Schmidt J, Boele van Hensbroek M, Towards Sustainable Research Capacity Development and Research Ownership for Academic Institutes in Developing Countries: The Malawian Research Support Centre Model. J RES ADM 2011;42 (1):38-45
Kapito-Tembo A, Meshnick SR, van Hensbroek MB, Phiri K, Fitzgerald M, Mwapasa V, Marked reduction in prevalence of malaria parasitemia and anemia in HIV-infected pregnant women taking cotrimoxazole with or without sulfadoxine-pyrimethamine intermittent preventive therapy during pregnancy in Malawi. J INFECT DIS 2011;203 (4):464-472 [PubMed]
van Hensbroek MB, Jonker F, Bates I, Severe acquired anaemia in Africa: new concepts. BRIT J HAEMATOL 2011;154 (6):690-695 [PubMed]
Boele van Hensbroek M, Calis JCJ, Phiri KS, Vet R, Munthali F, Kraaijenhagen R, van den Berg H, Faragher B, Bates I, Molyneux ME, Pathophysiological mechanisms of severe anaemia in Malawian children. PLOS ONE 2010;5 (9):e12589 [PubMed]
Calis JCJ, Phiri KS, Vet RJWM, de Haan RJ, Munthali F, Kraaijenhagen RJ, Hulshof PJM, Molyneux ME, Brabin BJ, Boele van Hensbroek M, Bates I, Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia. AIDS 2010;24 (18):2883-2887 [PubMed]
Cheema B, Molyneux EM, Emmanuel JC, M'baya B, Esan M, Kamwendo H, Kalilani-Phiri L, Boele van Hensbroek M, Development and evaluation of a new paediatric blood transfusion protocol for Africa. TRANSFUSION MED 2010;20 (3):140-151 [PubMed]
Graham SM. The impact of HIV on respiratory disease in Malawian children. s.l.: s.n.; 2010. 174p. ISBN 978903010 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Heymans HSA, Brabin BJ; copromotor(s): Molyneux ME, Boele van Hensbroek M)
Phiri KS, Calis JCJ, Kachala D, Borgstein E, Waluza J, Bates I, Brabin B, Boele van Hensbroek M, Improved method for assessing iron stores in the bone marrow. J CLIN PATHOL 2009;62 (8):685-689 [PubMed]
Phiri KS, Calis JCJ, Siyasiya A, Bates I, Brabin B, Boele van Hensbroek M, New cut-off values for ferritin and soluble transferrin receptor for the assessment of iron deficiency in children in a high infection pressure area. J CLIN PATHOL 2009;62 (12):1103-1106 [PubMed]
Calis JCJ. Aetiology, pathogenesis & consequences of severe anaemia in Malawian children. HIV and other factors. s.l.: s.n.; 2008. 183p. ISBN 9789090228860 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Brabin BJ; copromotor(s): Boele van Hensbroek M)
Calis JCJ, Boele van Hensbroek M, de Haan RJ, Moons P, Brabin BJ, Bates I, HIV-associated anemia in children: a systematic review from a global perspective. AIDS 2008;22 (10):1099-1112 [PubMed]
Calis JCJ, Phiri KS, Faragher EB, Brabin BJ, Bates I, Cuevas LE, de Haan RJ, Phiri AI, Malange P, Khoka M, Hulshof PJM, van Lieshout L, Beld MGHM, teo YY, Rockett KA, Richardson A, Kwiatkowski DP, Molyneux ME, Boele van Hensbroek M, Severe anemia in Malawian children. NEW ENGL J MED 2008;358 (9):888-899 [PubMed]
Calis JCJ, Rotteveel HP, van der Kuyl AC, Zorgdrager F, Kachala D, Boele van Hensbroek M, Cornelissen M, Severe anaemia is not associated with HIV-1 env gene characteristics in Malawian children. BMC INFECT DIS 2008;8:26 [PubMed]
Phiri KS, Calis JCJ, Faragher B, Nkhoma E, Ng'oma K, Mangochi B, Molyneux ME, van Hensbroek MB, Long term outcome of severe anaemia in Malawian children. PLOS ONE 2008;3 (8):e2903-- [PubMed]
Nkhoma E, Boele van Hensbroek P, van Lieshout L, Boele van Hensbroek M, Severe anaemia in an 11-month-old girl. LANCET 2005;365 (9465):1202 [PubMed]
Stepniewska K, Day N, Babiker A, Lalloo D, Warrell D, Olliaro P, White N [Contributors: Day N, Peto T, Winstanley P, Boele van Hensbroek M, Lalloo DG, White N, et al -]] , A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria. T ROY SOC TROP MED H 2001;95 (6):637-650 [PubMed]
Boele van Hensbroek M , de Vries E, Dolan G, Schneeberger P, Rash and petechiae as presenting signs of Q fever. PEDIATR INFECT DIS J 2000;19 (4):358 [PubMed]
Enwere GC, van Hensbroek MB, Jaiteh B, Palmer A, Onyiorah E, Schneider G, Weber MW, Greenwood BM, Biochemical and haematological variables in Gambian children with cerebral malaria. ANN TROP PAEDIATR 1999;19 (4):327-332 [PubMed]
Weber MW, Zimmermann U, van Hensbroek MB, Frenkel J, Palmer A, Ehrich JH, Greenwood BM, Renal involvement in Gambian children with cerebral or mild malaria. TROP MED INT HEALTH 1999;4 (5):390-394 [PubMed]
Zijlmans CWR, de Boom WHC, Frenkel J, Boele van Hensbroek M, De behandeling van malaria bij kinderen. TIJDSCHR KINDERGENEESKD 1999;67 (4):-
Boele van Hensbroek M, The role of the qinghaosu derivatives in the treatment of severe malaria. MED TROP (MARS) 1998;58 (3 Suppl):59-60 [PubMed]
Enwere G, van Hensbroek MB, Adegbola R, Palmer A, Onyiora E, Weber M, Greenwood B, Bacteraemia in cerebral malaria. ANN TROP PAEDIATR 1998;18 (4):275-278 [PubMed]
Gravenor MB, van Hensbroek MB, Kwiatkowski D, Estimating sequestered parasite population dynamics in cerebral malaria. P NATL ACAD SCI USA 1998;95 (13):7620-7624 [PubMed]
Bojang KA, Palmer A, Boele van Hensbroek M , Banya WA, Greenwood BM, Management of severe malarial anaemia in Gambian children. T ROY SOC TROP MED H 1997;91 (5):557-561 [PubMed]
Bojang KA, van Hensbroek MB, Palmer A, Banya WA, Jaffar S, Greenwood BM, Predictors of mortality in Gambian children with severe malaria anaemia. ANN TROP PAEDIATR 1997;17 (4):355-359 [PubMed]
Jaffar S, van Hensbroek MB, Palmer A, Schneider G, Greenwood B, Predictors of a fatal outcome following childhood cerebral malaria. AM J TROP MED HYG 1997;57 (1):20-24 [PubMed]
Kager PA, Zijlmans CW, Boele van Hensbroek M , Wetsteyn JC, De behandeling van malaria. NED TIJDSCHR GENEESKD 1997;141 (37):1774-1778 [PubMed]
van Hensbroek MB, Palmer A, Jaffar S, Schneider G, Kwiatkowski D, Residual neurologic sequelae after childhood cerebral malaria. J PEDIATR-US 1997;131 (1 Part 1):125-129 [PubMed]
Giadom B, de Veer GE, van Hensbroek MB, Corrah PT, Jaffar S, Greenwood BM, A comparative study of parenteral chloroquine, quinine and pyrimethamine-sulfadoxine in the treatment of Gambian children with complicated, non-cerebral malaria. ANN TROP PAEDIATR 1996;16 (2):85-91 [PubMed]
Müller O, van Hensbroek MB, Jaffar S, Drakeley C, Okorie C, Joof D, Pinder M, Greenwood B, A randomized trial of chloroquine, amodiaquine and pyrimethamine-sulphadoxine in Gambian children with uncomplicated malaria. TROP MED INT HEALTH 1996;1 (1):124-132 [PubMed]
Muntendam AH, Jaffar S, Bleichrodt N, van Hensbroek MB, Absence of neuropsychological sequelae following cerebral malaria in Gambian children. T ROY SOC TROP MED H 1996;90 (4):391-394 [PubMed]
Onyiorah E, van Hensbroek MB, Jah MS, Greenwood B, Early clinical failures after pyrimethamine-sulfadoxine treatment of uncomplicated falciparum malaria. T ROY SOC TROP MED H 1996;90 (3):307-308 [PubMed]
van Hensbroek MB, Kwiatkowski D, van den Berg B, Hoek FJ, van Boxtel CJ, Kager PA, Quinine pharmacokinetics in young children with severe malaria. AM J TROP MED HYG 1996;54 (3):237-242 [PubMed]
van Hensbroek MB, Onyiorah E, Jaffar S, Schneider G, Palmer A, Frenkel J, Enwere G, Forck S, Nusmeijer A, Bennett S, Greenwood B, Kwiatkowski D, A trial of artemether or quinine in children with cerebral malaria. NEW ENGL J MED 1996;335 (2):69-75 [PubMed]
van Hensbroek MB, Palmer A, Onyiorah E, Schneider G, Jaffar S, Dolan G, Memming H, Frenkel J, Enwere G, Bennett S, Kwiatkowski D, Greenwood B, The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria. J INFECT DIS 1996;174 (5):1091-1097 [PubMed]
Allan RJ, Beattie P, Bate C, van Hensbroek MB, Morris-Jones S, Greenwood BM, Kwiatkowski D, Strain variation in tumor necrosis factor induction by parasites from children with acute falciparum malaria. INFECT IMMUN 1995;63 (4):1173-1175 [PubMed]
van Hensbroek MB, Morris-Jones S, Meisner S, Jaffar S, Bayo L, Dackour R, Phillips C, Greenwood BM, Iron, but not folic acid, combined with effective antimalarial therapy promotes haematological recovery in African children after acute falciparum malaria. T ROY SOC TROP MED H 1995;89 (6):672-676 [PubMed]
Jakobsen PH, McKay V, Morris-Jones SD, McGuire W, van Hensbroek MB, Meisner S, Bendtzen K, Schousboe I, Bygbjerg IC, Greenwood BM, Increased concentrations of interleukin-6 and interleukin-1 receptor antagonist and decreased concentrations of beta-2-glycoprotein I in Gambian children with cerebral malaria. INFECT IMMUN 1994;62 (10):4374-4379 [PubMed]
Whittle H, Boele van Hensbroek M. Malaria in: Lankinen KS, Bergström S, Makela PH, Peltomaa M, editors. Health and disease in developing countries. London: MacMaillan; 1994., p. 147-162
Rietmeijer CA, Judson FN, van Hensbroek MB, Ehret JM, Douglas JM Jr, Unsuspected Chlamydia trachomatis infection in heterosexual men attending a sexually transmitted diseases clinic: evaluation of risk factors and screening methods. SEX TRANSM DIS 1991;18 (1):28-35 [PubMed]
Key publications

Calis JCJ, Phiri KS, Faragher EB, Brabin BJ, Bates I, Cuevas LE, de Haan RJ, Phiri AI, Malange P, Khoka M, Hulshof PJM, van Lieshout L, Beld MGHM, teo YY, Rockett KA, Richardson A, Kwiatkowski DP, Molyneux ME, Boele van Hensbroek M, Severe anemia in Malawian children. NEW ENGL J MED 2008;358 (9):888-899 [PubMed]
Jonker FAM, Calis JCJ, Phiri K, Kraaijenhagen RJ, Brabin BJ, Faragher B, Wiegerinck ET, Tjalsma H, Swinkels DW, van Hensbroek MB, Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiency. PLOS ONE 2013;8 (12):e78964 [PubMed]
Jonker FAM, Boele van Hensbroek M, Anaemia, iron deficiency and susceptibility to infections. J INFECTION 2014;69 (Suppl. 1):S23-S27 [PubMed]
Esan MO, van Hensbroek MB, Nkhoma E, Musicha C, White SA, ter Kuile FO, Phiri KS, Iron supplementation in HIV-infected Malawian children with anemia: a double-blind, randomized, controlled trial. CLIN INFECT DIS 2013;57 (11):1626-1634 [PubMed]
Phiri K, Esan M, Boele van Hensbroek M, Khairallah C, Faragher B, ter Kuile FO, Effect of intermittent preventative therapy for secondary prevention of severe malarial anaemia reply. LANCET INFECT DIS 2012;12 (12):906-907 [PubMed]


All Publications

Curriculum Vitae

University degrees
• B.A. University of Amsterdam 1985
• Medical Degree, University of Amsterdam 1989
• PhD. University of Amsterdam 1996
• Dutch equivalent of the CCST in Paediatrics 10-2000 (renewed 2005 and 2010)


Current appointments
• Professor in Global Child health

• Consultant in paediatrics infectious diseases and staff member of the Department of Paediatric Infection & Immunology (KHI), Emma Children’s Hospital, AMC.

• Head of the ‘Global Child Health Group’ (GCHG), of the Emma Children’s Hospital AMC

• staff memeber of the Amsterdam Institute of Global Health & Development,  Department of Global health, AMC.


Previous appointments
• Wellcome Trust Career Development Fellow in Clinical Tropical Medicine, based in the MLW Research Laboratories, Blantyre, Malawi (2001-2006).
• Consultant in Paediatrics, Department of Paediatrics, Queen Elisabeth Central Hospital, College of Medicine, University of Malawi, Blantyre, Malawi (2001-2005).
• Honorary Consultant Paediatrics, Alder Hey Children’s Hospital, Liverpool, United Kingdom (2005-08).
• Senior Lecturer in Tropical Paediatrics and staff member Child and Reproductive Health Group, Liverpool School of Tropical Medicine, United Kingdom (2005-2009).
• Fellow Paediatric Infectious diseases, EKZ-AMC (2008-2010)


Research Experience
• In-vivo and in-vitro resistance of P. falciparum against commonly used antimalarials in Kilgoris, Kenya (1985-1986)
• Evaluation of risk factors and screening methods for Chlamydia trachomatis infections in men attending the Sexual Transmitted Disease Clinic, CDC, Denver, USA, 1987
• Studies into the pathogenesis, treatment and outcome of uncomplicated and severe malaria in Gambian children, Medical Research Council Laboratories, Fajara, The Gambia 1991 - 1995.
• Studies into the aetiology pathogenesis and long term outcome of severe anaemia in Malawian children (Wellcome Trust Career Development Fellowship (2001-2006).
• Principle applicant (coordinator) of the Malawi-Amsterdam-Liverpool-(COMMAL) research programme (2005-2011)


Research activities:
• 2006-2012: Principal applicant NWO funded COMMAL Programme. Title: ‘College of Medicine, Malawi-Amsterdam-Liverpool partnership for Research Capacity Development through the establishment of a Research Support Centre in the College of Medicine, University of Malawi (Awarded: €850,000)
• 2006-2012: Principal applicant double blind randomised trial to evaluate the use of Coartem as Intermitted Preventive Treatment –post discharge (IPTpd) in children following a severe malaria anaemia episode (Awarded €650,000, NWO funded).
• 2007-2013: Principal applicant double blind randomised trial to evaluate the effect of iron supplementation in haematological recovery in HIV infected anaemic children (Awarded €250,000, NWO funded).
• 2013-2015: Co-applicant AFRIM study: Appropriate Fluid Resuscitation for Shock in Severely Malnourished Children. P.I. J. v Woensel (Awarded €200,000, Funder MSF).
• 2011-2015: Coordinator U5 study: Evaluation of the impact of the Health Insurance Fund program on maternal and child health in Kwara state, Nigeria. (Awarded €767,000, Funder HIF).

• 2012-2015: Principle applicant (coordinator) of the ARISE programme on Research Capacity Building for Africa (Awarded €2,8 mij.)

 

Teaching and coordination of teaching
Paediatric technical advisor to MSF:
• MSF head-office staff 2007-2011
• Pakistan mission: Evaluation of Paediatric care provided by MSF. October 2010.
• Democratic Republic of Congo mission: Evaluation of high paediatric mortality rates in Dubie. April 2009.
• Haiti mission: Evaluation of neonatal care provided and advice on refurbishing the MSF hospital. November 2008.
• Somalia mission MSF: Evaluation of paediatric care provided and advise on high infant mortality rates, November 2007.


Publications (10 recent/important)

Phiri K, Esan M, Boele van Hensbroek M, Khairallah C, Faragher B, ter Kuile F. Intermittent Preventive Therapy for malaria in the post-discharge management of severe anaemia in pre-school children; a multi-centre, randomized, placebo-controlled trial in Southern Malawi, Lancet Infectious Diseases, 2011, 12;3: 191-200.

Kapito-Tembo A, Meshnick SR, Boele van Hensbroek M, Phiri K, Fitzgerald M, Mwapasa V. Marked reduction in prevalence of malaria parasitemia and anemia in HIV-infected pregnant women taking cotrimoxazole with or without sulfadoxine-pyrimethamine intermittent preventive therapy during pregnancy in Malawi. J Infect Dis. 2011 Feb 15;203(4):464-72.

Boele van Hensbroek M, Jonkers F, Fijnvandraat K, Bates I. (2011) Severe anaemia in Africa, new concepts. Invited review: British Journal of Haematology (2011, 154, 6, 690-695).

Boele van Hensbroek M, Calis J, Phiri K, Vet R, Munthali F, Kraaijenhagen R, van den Berg H, Faragher B, Bates I and Molyneux M. Pathophysiological mechanisms of severe anaemia in Malawian children 2010. PLoS One 5 (9): el2589.

Cheema B, Molyneux EM, Emmanuel JC, M’baya M, Esan M, Kamwendo K, Kalilani L and Boele van Hensbroek M. Development and evaluation of a new paediatric blood transfusion protocol for Africa. Transfusion Medicine, 2010, 20, 140–151

Calis JC, Phiri KS, Vet RJ, de Haan RJ, Munthali F, Kraaijenhagen RJ, Hulshof PJ, Molyneux ME, Brabin BJ, Boele van Hensbroek M, Bates I. Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia. AIDS. 2010 Nov 27;24(18):2883-7.

Calis J, Phiri K, Faragher B, Brabin B, Bates I, Cuevas L, de Haan R, Phiri A, Malange P, Khoka M, Hulshof P, Lieshout L, Beld M, Teo Y, Rockett K, Richardson A, Kwiatkowski D, Molyneux M, Boele van Hensbroek M. Severe Anemia in Malawian children 2008. New England Journal of Medicine. 358(9)12-23.

Nkhoma E., Boele van Hensbroek P, Lieshout v L, Boele van Hensbroek M. Severe anaemia in an 11month-old girl. 2005 Lancet 365:1202.

Boele van Hensbroek M, Palmer A, Onyiorah E, Schneider G, Jaffar S, Dolan G,
Memming H, Frenkel J, Enwere G, Bennett S, Kwiatkowski D, Greenwood B. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria. J Infect Dis. 1996 Nov;174(5):1091-7.

Boele van Hensbroek M. Onyiorah E. Jaffar S. Schneider G. Palmer A. Frenkel J. Enwere G. Forck S. Nusmeijer A. Bennett S. Greenwood B. Kwiatkowski D. 1996. A trial of artemether or quinine in children with cerebral malaria. New England Journal of Medicine 335(2):69-75.

 

Research programmes

Programmes

NACCAP-COMMAL (NWO) research and capacity building programme 2005-2012.

NACCAP II (NWO) RSC network programme: 2012-2015

MACHS programme: Impact of a health insurance system on maternal and cHild health in Nigeria: 2010-2015

AFRIM programme: Fluid management in severely malnourished, shocked children in Africa

OPTIMISM study: enzym supplementation study in severe manutrition in Malawi: 2012-2014

TRACT (TRansfusion and TReatment of severe Anaemia in African Children), multicentre : a randomised controlled Trial, African (2012-2016)

Crossing Boarders programme: etnicity and envirment factors in the disease susceptibility of children (in preparation)

Faculty
Prof. dr. M. Boele van Hensbroek MD PhD
J.B.M. van Woensel MD PhD

Postdocs
Dr. J.C.J. Calis MD PhD
Dr. F.A.M. Jonker MD PhD
W.P. Voskuijl

PhD Students
G.O.E. Abd-Elfarag
S.A. Aderibigbe MD
R.H. Bartels
A. Dhabangi
A.W.D. Edridge MD
M.H.W. Huibers MD
T. Jupimai
F. Kiemde
J.N. Oliwa
Drs. D. Brals (AIGHD)

Prof. dr. T.W. Kuijpers MD PhD (Infection and inflammation: on the crossroad of hematology and immunology)

Other research related activities
  • Contribution to guidelines and protocols, MSF paeditric guidelines
  • Contribution to training of professionals, MSF-OCA
  • Contribution to training of professionals, University of Amsterdam
  • Contribution to training of professionals, Liverpool School of Tropical Medicine, UK
Current research funding
  • None reported