• Principal Investigator
  • Female

Prof. dr. M. Goddijn MD PhD

Position:
Main activities: Patient care, Research
Specialisation:
foto M. Goddijn is one of the AMC Principal Investigators
Focus of research:

Early Pregnancy

Recurrent Miscarriage

Female Fertility Preservation

Oocyte Freezing

Subfertility

 

 

 

 

AMC themes: Reproduction and development
Departments: Center for Reproductive Medicine, Obstetrics and Gynaecology
Balkenende EME, Dondorp W, Ploem MC, Lambalk CB, Goddijn M, Mol F, A mother's gift of life: exploring the concerns and ethical aspects of fertility preservation for mother-to-daughter oocyte donation. HUM REPROD 2017;32 (1):2-6 [PubMed]
Dahhan T, Balkenende EME, Beerendonk CCM, Fleischer K, Stoop D, Bos AME, Lambalk CB, Schats R, van Golde RJT, Schipper J, Louwe LA, Cantineau AEP, Smeenk JMJ, de Bruin JP, Reddy N, Kopeika Y, van der Veen F, van Wely M, Linn SC, Goddijn M, Stimulation of the ovaries in women with breast cancer undergoing fertility preservation: Alternative versus standard stimulation protocols; the study protocol of the STIM-trial. CONTEMP CLIN TRIALS 2017;61:96-100 [PubMed]
Dreyer K, van Rijswijk J, Mijatovic V, Goddijn M, Verhoeve HR, van Rooij IAJ, Hoek A, Bourdrez P, Nap AW, Rijnsaardt-Lukassen HGM, Timmerman CCM, Kaplan M, Hooker AB, Gijsen AP, van Golde R, van Heteren CF, Sluijmer AV, de Bruin JP, Smeenk JMJ, de Boer JAM, Scheenjes E, Duijn AEJ, Mozes A, Pelinck MJ, Traas MAF, van Hooff MHA, van Unnik GA, de Koning CH, van Geloven N, Twisk JWR, Hompes PGA, Mol BWJ, Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women. NEW ENGL J MED 2017;376 (21):2043-2052 [PubMed]
Kersten FAM, Nelen WLDM, van den Boogaard NM, van Rumste MM, Koks CA, Inthout J, Verhoeve HR, Pelinck MJ, Boks DES, Gianotten J, Broekmans FJM, Goddijn M, Braat DDM, Mol BWJ, Hermens RPGM, Implementing targeted expectant management in fertility care using prognostic modelling: a cluster randomized trial with a multifaceted strategy. HUM REPROD 2017;32 (8):1648-1657 [PubMed]
Rikken JF, Kowalik CR, Emanuel MH, Mol BWJ, van der Veen F, van Wely M, Goddijn M, Septum resection for women of reproductive age with a septate uterus. COCHRANE DB SYST REV 2017;2017 (1):CD008576 [PubMed]
van den Berg MMJ, Dancet EAF, Erlikh T, van der Veen F, Goddijn M, Hajenius PJ, Patient-centered early pregnancy care: a systematic review of quantitative and qualitative studies on the perspectives of women and their partners. HUM REPROD UPDATE 2017;ahead of print [PubMed]
Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, Gupta P, Dawood F, Koot YE, Atik RB, Bloemenkamp KWM, Brady R, Briley A, Cavallaro R, Cheong YC, Chu J, Eapen A, Essex H, Ewies A, Hoek A, Kaaijk EM, Koks CA, Li TC, MacLean M, Mol BW, Moore J, Parrott S, Ross JA, Sharpe L, Stewart J, Trépel D, Vaithilingam N, Farquharson RG, Kilby MD, Khalaf Y, Goddijn M, Regan L, Rai R, PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation. HEALTH TECHNOL ASSES 2016;20 (41):1-92 [PubMed]
Dahhan S. Fertility preservation in women: exploring clinical dilemmas. S.l.: s.n.; 2016. 190p. ISBN 978-94-6233-211-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Linn SC; copromotor(s): Goddijn M, Dancet EAF)
de Groot M, Dancet E, Repping S, Goddijn M, Stoop D, van der Veen F, Gerrits T, Perceptions of oocyte banking from women intending to circumvent age-related fertility decline. ACTA OBSTET GYN SCAN 2016;95 (12):1396-1401 [PubMed]
Groenewoud ER, Cohlen BJ, Al-Oraiby A, Brinkhuis EA, Broekmans FJM, de Bruin JP, van den Dool G, Fleisher K, Friederich J, Goddijn M, Hoek A, Hoozemans DA, Kaaijk EM, Koks CAM, Laven JSE, van der Linden PJQ, Manger AP, Slappendel E, Spinder T, Kollen BJ, Macklon NS, A randomized controlled, non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer. HUM REPROD 2016;31 (7):1483-1492 [PubMed]
Kersten FAM, Hermens RPGM, Braat DDM, Tepe E, Sluijmer A, Kuchenbecker WK, van den Boogaard N, Mol BWJ, Goddijn M, Nelen WLDM [Contributors: Hompes PG, Verhoeve HR, Gianotten J, de Bruin JP, de Koning CH, Koks CA, Broekmans FJ, Manger AP, Muijsers GJJM, Kwee J, Scheffer GJ, van Rijn JM, Pelinck MJ, van Rooij IA, Hoek A, Spinder T, van Rumste MM, Boks D, Vollebergh JH, Scheenjes E, van der Ploeg JM]] , Tailored expectant management in couples with unexplained infertility does not influence their experiences with the quality of fertility care. HUM REPROD 2016;31 (1):108-116 [PubMed]
Koot YEM, van Hooff SR, Boomsma CM, van Leenen D, Groot Koerkamp MJA, Goddijn M, Eijkemans MJC, Fauser BCJM, Holstege FCP, Macklon NS, An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF. SCI REP-UK 2016;6:19411 [PubMed]
Korevaar TIM, Nieboer D, Bisschop PHLT, Goddijn M, Medici M, Chaker L, de Rijke YB, Jaddoe VWV, Visser TJ, Steyerberg EW, Tiemeier H, Vrijkotte TG, Peeters RP, Risk factors and a clinical prediction model for low maternal thyroid function during early pregnancy: two population-based prospective cohort studies. CLIN ENDOCRINOL 2016;85 (6):902-909 [PubMed]
van den Belt-Dusebout AW, Spaan M, Lambalk CB, Kortman M, Laven JSE, van Santbrink EJP, van der Westerlaken LAJ, Cohlen BJ, Braat DDM, Smeenk JMJ, Land JA, Goddijn M, van Golde RJT, van Rumste MM, Schats R, Jozwiak K, Hauptmann M, Rookus MA, Burger CW, van Leeuwen FE, Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer EDITORIAL COMMENT. OBSTET GYNECOL SURV 2016;71 (10):601-602
van den Belt-Dusebout AW, Spaan M, Lambalk CB, Kortman M, Laven JSE, van Santbrink EJP, van der Westerlaken LAJ, Cohlen BJ, Braat DDM, Smeenk JMJ, Land JA, Goddijn M, van Golde RJT, van Rumste MM, Schats R, Józwiak K, Hauptmann M, Rookus MA, Burger CW, van Leeuwen FE, Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer. JAMA-J AM MED ASSOC 2016;316 (3):300-312 [PubMed]
van den Boogaard E, Vissenberg R, Land JA, van Wely M, Ven der Post JAM, Goddijn M, Bisschop PH, Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review. HUM REPROD UPDATE 2016;22 (4):532-533 [PubMed]
van Dijk MM, Vissenberg R, Bisschop PH, Dawood F, van Wely M, Goddijn M, Farquharson RG, Is subclinical hypothyroidism associated with lower live birth rates in women who have experienced unexplained recurrent miscarriage?. REPROD BIOMED ONLINE 2016;33 (6):745-751 [PubMed]
Vissenberg R. The influence of thyroid disorders on adverse pregnancy outcomes. S.l.: s.n.; 2016. 189p. ISBN 978-94-6299-306-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Post JAM, Fliers E; copromotor(s): Goddijn M, Bisschop PHLT)
Vissenberg R, Fliers E, van der Post JAM, van Wely M, Bisschop PH, Goddijn M, Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies. GYNECOL ENDOCRINOL 2016;32 (2):132-135 [PubMed]
Vissenberg R, Vrijkotte TGM, van der Post JAM, Fliers E, Goddijn M, Bisschop PH, Abnormal thyroid function parameters in the second trimester of pregnancy are associated with breech presentation at term: a nested cohort study. EUR J OBSTET GYN R B 2016;199:169-174 [PubMed]
Balkenende EME, Dahhan T, Repping S, de Melker AA, van der Veen F, Goddijn M, Eicelvitrificatie: voor wie eigenlijk? Een dwarsdoorsnede-onderzoek. NED TIJDSCHR GENEESKD 2015;159:A9361 [PubMed]
Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, Gupta P, Dawood F, Koot YEM, Bender Atik R, Bloemenkamp KWM, Brady R, Briley AL, Cavallaro R, Cheong YC, Chu JJ, Eapen A, Ewies A, Hoek A, Kaaijk EM, Koks CAM, Li TC, MacLean M, Mol BW, Moore J, Ross JA, Sharpe L, Stewart J, Vaithilingam N, Farquharson RG, Kilby MD, Khalaf Y, Goddijn M, Regan L, Rai R, A Randomized Trial of Progesterone in Women with Recurrent Miscarriages. NEW ENGL J MED 2015;373 (22):2141-2148 [PubMed]
Dahhan T, Mol F, Kenter GG, Balkenende EME, de Melker AA, van der Veen F, Dancet EAF, Goddijn M, Fertility preservation: a challenge for IVF-clinics. EUR J OBSTET GYN R B 2015;194:78-84 [PubMed]
de Jong PG. Inherited thrombophilia and pregnancy complications. S.l.: s.n.; 2015. 299p. ISBN 978-94-6259-711-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S; copromotor(s): Goddijn M)
de Jong PG, Quenby S, Bloemenkamp KWM, Braams-Lisman BAM, de Bruin JP, Coomarasamy A, David M, DeSancho MT, van der Heijden OWH, Hoek A, Hutten BA, Jochmans K, Koks CAM, Kuchenbecker WKM, Mol BWJ, Torrance HL, Scheepers HCJ, Stephenson MD, Verhoeve HR, Visser J, de Vries JIP, Goddijn M, Middeldorp S, ALIFE2 study: low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia--study protocol for a randomized controlled trial. TRIALS 2015;16 (1):208 [PubMed]
Kersten FAM, Hermens RPGM, Braat DDM, Hoek A, Mol BWJ, Goddijn M, Nelen WLDM, Overbehandeling bij onverklaarde subfertiliteit. NED TIJDSCHR GENEESKD 2015;159:A8689 [PubMed]
Kersten FAM, Hermens RPGM, Braat DDM, Hoek A, Mol BWJ, Goddijn M, Nelen WLDM, Overtreatment in couples with unexplained infertility. HUM REPROD 2015;30 (1):71-80 [PubMed]
Kersten FAM, Hermens RPGM, Braat DDM, Hoek A, Mol BWJ, Goddijn M, Nelen WLDM [Contributors: Hompes PG, Verhoeve HR, Gianotten J, de Bruin JP, de Koning CH, Koks CA, Broekmans FJ, Manger AP, Muijsers GJJM, Kwee J, Scheffer GJ, van Rijn JM, Pelinck MJ, van Rooij IA, Spinder T, Sluijmer A, van Rumste MM, Boks D, Vollebergh JH, Tepe E, Scheenjes E, Kuchenbecker WK, van der Ploeg JM]] , Overtreatment in couples with unexplained infertility (vol 30, pg 71, 2015). HUM REPROD 2015;30 (11):2694 [PubMed]
Kolte AM, Bernardi LA, Christiansen OB, Quenby S, Farquharson RG, Goddijn M, Stephenson MD, Terminology for pregnancy loss prior to viability: a consensus statement from the ESHRE early pregnancy special interest group. HUM REPROD 2015;30 (3):495-498 [PubMed]
van den Berg MMJ, Goddijn M, Ankum WM, van Woerden EE, van der Veen F, van Wely M, Hajenius PJ, Early pregnancy care over time: should we promote an early pregnancy assessment unit?. REPROD BIOMED ONLINE 2015;31 (2):192-198 [PubMed]
Vissenberg R, Manders VD, Mastenbroek S, Fliers E, Afink GB, Ris-Stalpers C, Goddijn M, Bisschop PH, Pathophysiological aspects of thyroid hormone disorders/thyroid peroxidase autoantibodies and reproduction. HUM REPROD UPDATE 2015;21 (3):378-387 [PubMed]
Vissenberg R, van Dijk MM, Fliers E, van der Post JAM, van Wely M, Bloemenkamp KWM, Hoek A, Kuchenbecker WK, Verhoeve HR, Scheepers HCJ, Rombout-de Weerd S, Koks C, Zwart JJ, Broekmans F, Verpoest W, Christiansen O, Post M, Papatsonis DNM, Verberg MFG, Sikkema J, Mol BW, Bisschop PH, Goddijn M, Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study). CONTEMP CLIN TRIALS 2015;44:134-138 [PubMed]
Dahhan T, Dancet EAF, Miedema DV, van der Veen F, Goddijn M, Reproductive choices and outcomes after freezing oocytes for medical reasons: a follow-up study. HUM REPROD 2014;29 (9):1925-1930 [PubMed]
de Jong PG, Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S, Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. COCHRANE DB SYST REV 2014;2014 (7):CD004734 [PubMed]
Kaandorp SP, van Mens TE, Middeldorp S, Hutten BA, Hof MHP, van der Post JAM, van der Veen F, Goddijn M, Time to conception and time to live birth in women with unexplained recurrent miscarriage. HUM REPROD 2014;29 (6):1146-1152 [PubMed]
Kolte AM, van Oppenraaij RH, Quenby S, Farquharson RG, Stephenson M, Goddijn M, Christiansen OB, Non-visualized pregnancy losses are prognostically important for unexplained recurrent miscarriage. HUM REPROD 2014;29 (5):931-937 [PubMed]
Koot YEM. Maternal factors in Early Pregnancy Loss Implantations failure, early non-visualised pregnancy loss and recurrent miscarriage. S.l.: s.n.; 2014. 175p. ISBN 978-94-6108-860-4 Proefschrift Universiteit Utrecht, Department of Reproductive Medicine and Gynaecology. (Promotor(s): Macklon NS, van der Veen F; copromotor(s): Holstege FCP, Goddijn M)
van den Berg MMJ, Vissenberg R, Goddijn M, Recurrent miscarriage clinics. OBSTET GYN CLIN N AM 2014;41 (1):145-155 [PubMed]
van den Boogaard E. Optimizing quality of care for couples with recurrent miscarriage. S.l.: s.n.; 2014. 247p. ISBN 9789462593428 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Kremer JAM; copromotor(s): Goddijn M, Hermens RPMG)
van den Boogaard E, Hermens RPMG, Kremer JAM, van der Veen F, Goddijn M, Reply: Recurrent miscarriage: guidelines could be improved. HUM REPROD 2014;29 (6):1345 [PubMed]
Verschoor MAC, Lemmers M, Wekker MZ, Ankum WMP, Mol BWJBW, Goddijn M, Behandelopties voor vroege miskramen; nieuwe inzichten. NED TIJDSCHR GENEESKD 2014;158:A7900 [PubMed]
Verschoor MAC, Lemmers M, Wekker MZ, Huirne JAF, Goddijn M, Mol BWJ, Ankum WM, Practice variation in the management of first trimester miscarriage in the Netherlands: a nationwide survey. OBSTET GYNECOL INT 2014;2014:387860 [PubMed]
Balkenende EME, Dahhan T, Linn SC, Jager NGL, Beijnen JH, Goddijn M, A prospective case series of women with estrogen receptor-positive breast cancer: levels of tamoxifen metabolites in controlled ovarian stimulation with high-dose tamoxifen. HUM REPROD 2013;28 (4):953-959 [PubMed]
Dahhan T, Balkenende E, van Wely M, Linn S, Goddijn M, Tamoxifen or letrozole versus standard methods for women with estrogen-receptor positive breast cancer undergoing oocyte or embryo cryopreservation in assisted reproduction. COCHRANE DB SYST REV 2013;2013 (11):CD010240 [PubMed]
de Jong PG, Goddijn M, Middeldorp S, Antithrombotic therapy for pregnancy loss. HUM REPROD UPDATE 2013;19 (6):656-673 [PubMed]
Musters AM, Koot YEM, van den Boogaard NM, Kaaijk E, Macklon NS, van der Veen F, Nieuwkerk PT, Goddijn M, Supportive care for women with recurrent miscarriage: a survey to quantify women's preferences. HUM REPROD 2013;28 (2):398-405 [PubMed]
van den Boogaard E, Cohn DM, Korevaar JC, Dawood F, Vissenberg R, Middeldorp S, Goddijn M, Farquharson RG, Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage. FERTIL STERIL 2013;99 (1):188-192 [PubMed]
van den Boogaard E, Hermens RPMG, Franssen AMHW, Doornbos JPR, Kremer JAM, van der Veen F, Goddijn M, Recurrent miscarriage: do professionals adhere to their guidelines. HUM REPROD 2013;28 (11):2898-2904 [PubMed]
van den Boogaard NM, Kersten FAM, Goddijn M, Bossuyt PMM, van der Veen F, Hompes PGA, Hermens RPMG, Braat DDM, Mol BWJ, Nelen WLDM [Contributors: van den Boogaard N, Kersten F, Goddijn M, Bossuyt P, van der Veen F, Hompes P, Hermens R, Braat D, Mol BW, Nelen W, Verhoeve H, Gianotten J, de Bruin JP, de Koning C, Koks C, Broekmans F, Zoet G, Muijsers G, Kwee J, Scheffer-Nijsen G, van Rijn JM, Hoek A, Pelinck MJ, van Rooy I, Spinder T, Sluijmer A, van Rumste M, Boks D, Vollebergh J, Tepe E, Scheenjes E, Kuchenbecker W, van der Ploeg J]] , Improving the implementation of tailored expectant management in subfertile couples: protocol for a cluster randomized trial. IMPLEMENT SCI 2013;8 (1):53 [PubMed]
van Leeuwen M, Vansenne F, Korevaar JC, van der Veen F, Goddijn M, Mol BWJ, Economic analysis of chromosome testing in couples with recurrent miscarriage to prevent handicapped offspring. HUM REPROD 2013;28 (7):1737-1742 [PubMed]
van Loendersloot L, van Wely M, Goddijn M, Repping S, Bossuyt P, van der Veen F, Pregnancy and twinning rates using a tailored embryo transfer policy. REPROD BIOMED ONLINE 2013;26 (5):462-469 [PubMed]
Goddijn M, Exalto N. De jonge zwangerschap [24] in: Heineman MJ, Bleker OP, Evers JLH, Heintz APM, editors. Obstetrie en gynaecologie. De voortplanting van de mens. Maarssen: Elsevier gezondheidzorg; 2003., p. 619-631
Hirshfeld-Cytron J, van Loendersloot LL, Mol BW, Goddijn M, Grobman WA, Moolenaar LM, Milad MP, Cost-effective analysis of oocyte cryopreservation: stunning similarities but differences remain. HUM REPROD 2012;27 (12):3639 [PubMed]
Musters AM. Reproductive choices in women with poor ovarian reserve and recurrent miscarriages. s.l.: s.n.; 2012. 173p. ISBN 9739090265131 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Repping S; copromotor(s): Goddijn M, Mochtar MH)
van den Berg MMJ, van Maarle MC, van Wely M, Goddijn M, Genetics of early miscarriage. BBA-MOL BASIS DIS 2012;1822 (12):1951-1959 [PubMed]
Vissenberg R, Goddijn M, Mol BW, van der Post JA, Fliers E, Bisschop PH, Schildklierdisfunctie bij zwangeren: klinische dilemma's. NED TIJDSCHR GENEESKD 2012;156 (49):A5163 [PubMed]
Vissenberg R, van den Boogaard E, van Wely M, van der Post JA, Fliers E, Bisschop PH, Goddijn M, Treatment of thyroid disorders before conception and in early pregnancy: a systematic review. HUM REPROD UPDATE 2012;18 (4):360-373 [PubMed]
Balkenende E, Dahhan T, van der Veen F, Goddijn M, Comment on GnRH analogue cotreatment with chemotherapy for preservation of ovarian function. FERTIL STERIL 2011;96 (4):e155-6; author reply e157 [PubMed]
de Jong PG, Goddijn M, Middeldorp S, Testing for inherited thrombophilia in recurrent miscarriage. SEMIN REPROD MED 2011;29 (6):540-547 [PubMed]
Franssen MTM, Musters AM, van der Veen F, Repping S, Leschot NJ, Bossuyt PMM, Goddijn M, Korevaar JC, Reproductive outcome after PGD in couples with recurrent miscarriage carrying a structural chromosome abnormality: a systematic review. HUM REPROD UPDATE 2011;17 (4):467-475 [PubMed]
Kaandorp SP. Unexplained recurrent miscarriage. s.l.: s.n.; 2011. 127p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Middeldorp S; copromotor(s): Goddijn M, van der Post JAM)
Kowalik CR, Goddijn M, Emanuel MH, Bongers MY, Spinder T, de Kruif JH, Mol BWJ, Heineman MJ, Metroplasty versus expectant management for women with recurrent miscarriage and a septate uterus. COCHRANE DB SYST REV 2011;2011 (6):CD008576 [PubMed]
Mol F, van den Boogaard E, van Mello NM, van der Veen F, Mol BW, Ankum WM, van Zonneveld P, Dijkman AB, Verhoeve HR, Mozes A, Goddijn M, Hajenius PJ, Guideline adherence in ectopic pregnancy management. HUM REPROD 2011;26 (2):307-315 [PubMed]
Musters AM, Repping S, Korevaar JC, Mastenbroek S, Limpens J, van der Veen F, Goddijn M, Pregnancy outcome after preimplantation genetic screening or natural conception in couples with unexplained recurrent miscarriage: a systematic review of the best available evidence. FERTIL STERIL 2011;95 (6):2153-2157 [PubMed]
Musters AM, Taminiau-Bloem EF, van den Boogaard E, van der Veen F, Goddijn M, Supportive care for women with unexplained recurrent miscarriage: patients' perspectives. HUM REPROD 2011;26 (4):873-877 [PubMed]
Stephenson MD, Goddijn M, A critical look at the evidence does not support PGD for translocation carriers with a history of recurrent losses. FERTIL STERIL 2011;95 (1):e1; author reply e2 [PubMed]
van den Boogaard E, Hermens RPMG, Leschot NJ, Baron R, Vollebergh JHA, Bernardus RE, van der Veen F, Kremer JAM, Goddijn M, Identification of barriers for good adherence to a guideline on recurrent miscarriage. ACTA OBSTET GYN SCAN 2011;90 (2):186-191 [PubMed]
van den Boogaard E, Hermens RPMG, Verhoeve HR, Kremer JAM, van der Veen F, Knegt AC, Goddijn M, Selective karyotyping in recurrent miscarriage: are recommended guidelines adopted in daily clinical practice?. HUM REPROD 2011;26 (8):1965-1970 [PubMed]
van den Boogaard E, Vissenberg R, Land JA, van Wely M, van der Post JAM, Goddijn M, Bisschop PH, Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review. HUM REPROD UPDATE 2011;17 (5):605-619 [PubMed]
van Loendersloot LL, Moolenaar LM, Mol BWJ, Repping S, van der Veen F, Goddijn M, Expanding reproductive lifespan: a cost-effectiveness study on oocyte freezing. HUM REPROD 2011;26 (11):3054-3060 [PubMed]
Vansenne F. Measuring the effects of genetic testing. Studies on thrombophilia, sickle cell trait, recurrent miscarriage and male subfertility. s.l.: s.n.; 2011. 221p. ISBN 9789461910752 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bossuyt PMM, Leschot NJ; copromotor(s): de Borgie CAJM, Goddijn M)
Vansenne F, Goddijn M, Redeker B, Snijder S, Gerssen-Schoorl K, Lemmink H, Leschot NJ, van der Veen F, Bossuyt PMM, de Borgie CAJM, Knowledge and perceived risks in couples undergoing genetic testing after recurrent miscarriage or for poor semen quality. REPROD BIOMED ONLINE 2011;23 (4):525-533 [PubMed]
Vissenberg R, Goddijn M, Is there a role for assisted reproductive technology in recurrent miscarriage?. SEMIN REPROD MED 2011;29 (6):548-556 [PubMed]
Cohn DM, Goddijn M, Middeldorp S, Korevaar JC, Dawood F, Farquharson RG, Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy. J THROMB HAEMOST 2010;8 (10):2208-2213 [PubMed]
de Melker AA, Verhoeve HR, Goddijn M, van der Veen F, Repping S, Voortplanting met behulp van gevitrificeerde oöcyten. NED TIJDSCHR GENEESKD 2010;154:A1715 [PubMed]
Franssen MTM. Efficiency of parental chromosome analysis in couples with recurrent miscarriage. s.l.: s.n.; 2010. 128p. ISBN 9789461080400 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Leschot NJ; copromotor(s): Bossuyt PMM, Goddijn M, Korevaar JC)
Goddijn M, Leschot NJ. Parental chromosome testing in: Farquharson RG, Stephenson MD, editors. Early Pregnancy. New York: Cambridge Universtiy Press; 2010., p. -
Kaandorp SP, Goddijn M, Middeldorp S, Antithrombotic Medications and Recurrent Miscarriage REPLY. NEW ENGL J MED 2010;363 (9):888
Kaandorp SP, Goddijn M, van der Post JAM, Hutten BA, Verhoeve HR, Hamulyák K, Mol BW, Folkeringa N, Nahuis M, Papatsonis DNM, Büller HR, van der Veen F, Middeldorp S, Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. NEW ENGL J MED 2010;362 (17):1586-1596 [PubMed]
Kaandorp SP, Lauw MN, van der Schoot CE, Goddijn M, van der Veen F, Koene HR, Biemond BJ, Middeldorp S, Prevalence of JAK2V617F mutation in women with unexplained recurrent miscarriage. J THROMB HAEMOST 2010;8 (12):2837-2839 [PubMed]
Kowalik CR, Mol BWJ, Veersema S, Goddijn M, Critical appraisal regarding the effect on reproductive outcome of hysteroscopic metroplasty in patients with recurrent miscarriage. ARCH GYNECOL OBSTET 2010;282 (4):465 [PubMed]
Musters AM, Twisk M, Leschot NJ, Oosterwijk C, Korevaar JC, Repping S, van der Veen F, Goddijn M, Perspectives of couples with high risk of transmitting genetic disorders. FERTIL STERIL 2010;94 (4):1239-1243 [PubMed]
van den Boogaard E, Goddijn M, Leschot NJ, Veen Fvd, Kremer JAM, Hermens RPMG, Development of guideline-based quality indicators for recurrent miscarriage. REPROD BIOMED ONLINE 2010;20 (2):267-273 [PubMed]
van den Boogaard E, Kaandorp SP, Franssen MTM, Mol BWJ, Leschot NJ, Wouters CH, van der Veen F, Korevaar JC, Goddijn M, Consecutive or non-consecutive recurrent miscarriage: is there any difference in carrier status?. HUM REPROD 2010;25 (6):1411-1414 [PubMed]
Vansenne F, de Borgie CAJM, Korevaar JC, Franssen MTM, Pajkrt E, Hansson KBM, Leschot NJ, Bossuyt PMM, van der Veen F, Goddijn M, Low uptake of prenatal diagnosis after established carrier status of a balanced structural chromosome abnormality in couples with recurrent miscarriage. FERTIL STERIL 2010;94 (1):296-U1305 [PubMed]
Goddijn M, de Jager F, Kaaijk EM, van der Veen F, Ankum WM, Hajenius PJ, Problemen vroeg in de zwangerschap vereisen speciale zorg: 'Jonge zwangerschapsunits'. NED TIJDSCHR GENEESKD 2009;153 (45):A601 [PubMed]
Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S, Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. COCHRANE DB SYST REV 2009;2009 (1):CD004734 [PubMed]
Franssen MTM, Korevaar JC, Tjoa WM, Leschot NJ, Bossuyt PMM, Knegt AC, Suykerbuyk RF, Hochstenbach R, van der Veen F, Goddijn M, Inherited unbalanced structural chromosome abnormalities at prenatal chromosome analysis are rarely ascertained through recurrent miscarriage. PRENATAL DIAG 2008;28 (5):408-411 [PubMed]
Goddijn M, Repping SR, van der Veen F, Leschot NJ, Voorbeelden van pre-implantatie- genetische diagnostiek versus prenatale diagnostiek bij dragerschap van genetische afwijkingen: voor--en nadelen. NED TIJDSCHR GENEESKD 2008;152 (27):1545-6; author reply 1546 [PubMed]
Goddijn M, van den Boogaard E, Steepers EAP, Erwich JJHM, Macklon NS, Land JA, Ankum WM, Richtlijn 'Herhaalde miskraam' (eerste herziening) van de Nederlandse Vereniging voor Obstetrie en Gynaecologie. NED TIJDSCHR GENEESKD 2008;152 (30):1665-1670 [PubMed]
Musters AM, Goddijn M, Korevaar JC, van der Veen F, Mastenbroek S, Repping S, Benefits of PGD in patients with recurrent miscarriages?. FERTIL STERIL 2008;90 (1):240-241 [PubMed]
Musters AM, Oosterwijk C, Repping S, Twisk M, Goddijn M, Korevaar JC, van der Veen F, Leschot NJ, Doelgroep is onwetend. MED CONTACT 2008;63 (23):978-983
van Oppenraaij RHF, Goddijn M, Lok CAR, Exalto N, De jonge zwangerschap: revisie van de Nederlandse benamingen voor klinische en echoscopische bevindingen. NED TIJDSCHR GENEESKD 2008;152 (1):20-24 [PubMed]
Franssen MTM, Korevaar JC, Leschot NJ, Bossuyt PMM, Knegt AC, Gerssen-Schoorl KBJ, Wouters CH, Hansson KBM, Hochstenbach PFR, Madan K, van der Veen F, Goddijn M, Risicofactoren voor structurele chromosoomafwijking bij 2 of meer miskramen als instrument voor selectieve karyotypering. NED TIJDSCHR GENEESKD 2007;151 (15):863-867 [PubMed]
Franssen MTM, Korevaar JC, van der Veen F, Boer K, Leschot NJ, Goddijn M, Management of recurrent miscarriage: evaluating the impact of a guideline. HUM REPROD 2007;22 (5):1298-1303 [PubMed]
Franssen MTM, Korevaar JC, van der Veen F, Leschot NJ, Bossuyt PMM, Goddijn M, Reactie op MCW Scholtes: Risicofactoren voor structurele chromosoomafwijkinge bij 2 of meer miskramen als instrument voor selectievve karyotypering. NED TIJDSCHR GENEESKD 2007;151:2350-2351
Franssen MTM, Korevaar JC, van der Veen F, Leschot NJ, Bossuyt PMM, Goddijn M, Reactie op W. Vlaanderen: Karyotypering van echtparen met herhaalde miskraam blijkt zinloos. NED TIJDSCHR OBSTET GYNAECOL 2007;120:31-33
Franssen MTM, Korevaar JC, van der Veen F, Leschot NJ, Bossuyt PMM, Goddijn M, Reactie op W. Vlaanderen: Risicofactoren voor structurele chromosoomafwijking bij 2 of meer miskramen als instrument voor selectieve karyotypering. NED TIJDSCHR GENEESKD 2007;151:2351-2352
Franssen MTM, Korevaar JC, van der Veen F, Leschot NJ, Bossuyt PMM, Goddijn M, Reproductive outcome after chromosome analysis in couples with two or more miscarriages: index [corrected]-control study. BMJ-BRIT MED J 2006;332 (7544):759-763 [PubMed]
Mastenbroek S, Goddijn M, van der Veen F, Repping S, Bossuyt PMM, Korevaar JC, Twisk M, Heineman MJ, PGD--a model to evaluate efficacy?. FERTIL STERIL 2006;85 (2):534-5; author reply 535-6 [PubMed]
Middeldorp S, Goddijn M, Herhaalde miskramen en het mogelijke nut van antistollingsbehandeling. TIJDSCHR VERLOSKUNDIGEN 2006;85:29-33
Middeldorp S, Goddijn M, Herhaalde miskramen en trombofilie. NED TIJDSCHR GENEESKD 2006;150 (4):189-193 [PubMed]
Franssen MTM, Korevaar JC, Leschot NJ, Bossuyt PMM, Knegt AC, Gerssen-Schoorl KBJ, Wouters CH, Hansson KBM, Hochstenbach R, Madan K, van der Veen F, Goddijn M, Selective chromosome analysis in couples with two or more miscarriages: case-control study. BMJ-BRIT MED J 2005;331 (7509):137-139 [PubMed]
Goddijn M, van Stralen M, Schuring-Blom H, Redeker B, van Leeuwen L, Repping S, Leschot N, van der Veen F, Detection of chromosome abnormalities by quantitative fluorescent PCR in ectopic pregnancies. GYNECOL OBSTET INVES 2005;60 (3):139-144 [PubMed]
Goddijn M, Joosten H, Knegt L, van der Veen F, Franssen M, Bonsel G, Leschot N, Reciprocal translocation carriers ascertained for recurrent miscarriage have a possibility to yield an unbalanced fetal chromosome pattern - Reply. HUM REPROD 2004;19 (9):2172
Goddijn M, Joosten JHK, Knegt AC, van derVeen F, Franssen MTM, Bonsel GJ, Leschot NJ, Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage. HUM REPROD 2004;19 (4):1013-1017 [PubMed]
Goddijn M. Chromosome abnormalities in first-trimester pregnancy loss. Amsterdam: s.n.; 2003. 111p. ISBN 9051707150 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Leschot NJ; copromotor(s): Bonsel GJ)
Goddijn M, Joosten J, Birnie E, Bonsel GJ, Bleker OP, Uyl-de Groot CA. Diagnostiek naar structurele chromosoomafwijkingen bij paren met herhaalde miskramen - Een richtlijn onderzoek in het Academische Medisch Centrum, Amsterdam. Amsterdam: IMTA/VWS; 2003. -p.
Goddijn M, Leschot NJ, Genetic aspects of miscarriage. BEST PRACT RES CL OB 2000;14 (5):855-865 [PubMed]
Goddijn M, Roos D, van Wely M, ten Kate FJ, Cohen DR, van der Veen F, Association of histologic features and cytogenetic abnormalities in ectopic pregnancies. FERTIL STERIL 2000;73 (6):1201-1205 [PubMed]
Goddijn M, van der Veen F, Ankum WM, Bonsel GJ, Leschot NJ, Boer K, Geen eenduidigheid over definitie, diagnostiek en behandeling van habituele abortus in Nederland. NED TIJDSCHR GENEESKD 1999;143 (17):897-902 [PubMed]
Goddijn M, Emanuel MH, Wiers PW, Eastham WN, Tuberculose als ongebruikelijke oorzaak van oligoamenorroe en infertiliteit. NED TIJDSCHR GENEESKD 1997;141 (2):105-107 [PubMed]
Goddijn M, Schipper HG, Spanjaard L, Wolf H, First Trimester Listeria monocytogenes Septicemia. INFECT DIS OBSTET GYNECOL 1997;5 (3):219-221 [PubMed]
Goddijn M, van 't Hof DB, Wiesenhaan PF, Inversio uteri bij herhaling. NED TIJDSCHR OBSTET GYNAECOL 1997;110:288-290
Goddijn M, van der Veen F, Schuring-Blom GH, Ankum WM, Leschot NJ, Cytogenetic characteristics of ectopic pregnancy. HUM REPROD 1996;11 (12):2769-2771 [PubMed]
Key publications

Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, Gupta P, Dawood F, Koot YEM, Bender Atik R, Bloemenkamp KWM, Brady R, Briley AL, Cavallaro R, Cheong YC, Chu JJ, Eapen A, Ewies A, Hoek A, Kaaijk EM, Koks CAM, Li TC, MacLean M, Mol BW, Moore J, Ross JA, Sharpe L, Stewart J, Vaithilingam N, Farquharson RG, Kilby MD, Khalaf Y, Goddijn M, Regan L, Rai R, A Randomized Trial of Progesterone in Women with Recurrent Miscarriages. NEW ENGL J MED 2015;373 (22):2141-2148 [PubMed]
Vissenberg R, van den Boogaard E, van Wely M, van der Post JA, Fliers E, Bisschop PH, Goddijn M, Treatment of thyroid disorders before conception and in early pregnancy: a systematic review. HUM REPROD UPDATE 2012;18 (4):360-373 [PubMed]
van den Belt-Dusebout AW, Spaan M, Lambalk CB, Kortman M, Laven JSE, van Santbrink EJP, van der Westerlaken LAJ, Cohlen BJ, Braat DDM, Smeenk JMJ, Land JA, Goddijn M, van Golde RJT, van Rumste MM, Schats R, Józwiak K, Hauptmann M, Rookus MA, Burger CW, van Leeuwen FE, Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer. JAMA-J AM MED ASSOC 2016;316 (3):300-312 [PubMed]
Kaandorp SP, Goddijn M, van der Post JAM, Hutten BA, Verhoeve HR, Hamulyák K, Mol BW, Folkeringa N, Nahuis M, Papatsonis DNM, Büller HR, van der Veen F, Middeldorp S, Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. NEW ENGL J MED 2010;362 (17):1586-1596 [PubMed]
Franssen MTM, Korevaar JC, van der Veen F, Leschot NJ, Bossuyt PMM, Goddijn M, Reproductive outcome after chromosome analysis in couples with two or more miscarriages: index [corrected]-control study. BMJ-BRIT MED J 2006;332 (7544):759-763 [PubMed]


All Publications

Research programmes

Reproductive Medicine

Recurrent Miscarriage (RM) is a multifactorial disease. The research programme focuses on the evaluation of diagnostic screening and therapy of couples with Recurrent Miscarriage. Research projects regarding RM will be performed within the Early Pregnancy Unit (EPU/AMC), in multicenter national setting (Dutch Fertility Consortium) or in an international setting (Promise network, UK; University of Chicago, USA, Miscarriage Clinic in Liverpool, UK, University of Brussels, and the Rigshospitalet, Copenhagen).
Recurrent miscarriage is associated with parental chromosome abnormalities, antiphospholipid antibody syndrome (APS), hereditary thrombophilia, thyroid auto immunity and uterus septum. All associated factors will be further investigated with regard to diagnostic strategies and/or potential therapeutic regimens. The applicant has already shown that parental chromosome testing does not reduce the number of handicapped children born and that anticoagulant therapy (NEJM 2010) and progesterone (NEJM 2015) is not of benefit in women with unexplained recurrent miscarriage. 
For women with RM a randomised uterine septum transsection trial (TRUST study/ NTR1676) is ongoing within the Dutch Fertility Consortium, as are the T4life trial (NTR3364) on levothyroxine versus placebo in women with RM and thyroid autoimmunity, and the Alife 2 trial (NTR3361) on heparin versus expectant management in women with RM and hereditary thrombophilia.  
Fertility Preservation The second researchline is the evaluation of safety and efficacy of fertility preservation options. The safety and efficacy of ovarian hyperstimulation regimens for purpose of fertility preservation in women with (breast) cancer is subject of the STIM trial (NTR4108). It is a collaborative effort with The Netherlands Cancer Institute /Antoni van Leeuwenhoek Hospital (NKI/AVL) and the Dutch Fertility Consortium. Clinical challenges of oocyte freezing like transgenerational oocyte freezing, and oocyte freezing in women with mosaic Turner syndrome will be studied. A follow up study on the health of children born after oocyte freezing in the Netherlands will be conducted.  

 

Faculty
Prof. dr. M. Goddijn MD PhD

Postdocs
Dr. P.J. Hajenius MD PhD
Dr. M.H. Mochtar MD PhD
Dr. F. Mol MD

PhD Students
Drs. E.M.E. Balkenende MD
Drs. M.M.J. van den Berg
M.M. Van Dijk
Drs. C.R. Kowalik
Drs. T.E. van Mens
J.F.W. Rikken
M.A.J. Smits
Drs. F. Kersten (Radboud University)

Others
M.M. Aker
T.S. de Vries

Prof. dr. F. van der Veen (Reproduction and development])

Prof. dr. S. Repping (Reproduction & Development -- Human Reproduction)

Other research related activities
  • Contribution to guidelines and protocols, Schildklierfunctiestoornissen NIV 2013
  • Contribution to guidelines and protocols, Recurrent Miscarriage ESHRE 2015
  • Contribution to guidelines and protocols, Fertiliteitspreservatie Vrouwen met Kanker NVOG/NKI 2015
  • Board of directors / Trustees / Supervisory board, ESHRE, coordinator SIG Early Pregnancy
  • Board of directors / Trustees / Supervisory board, board Nederlands Netwerk Fertiliteitspreservatie
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • PinkRibbon
  • Radboud Universiteit Nijmegen
  • ZonMw