• Principal Investigator
  • Female

Prof. dr. S.E. La Fleur

Position: Professor
Main activities: Research
Specialisation: Neurobiology of Energy Metabolism
foto S.E. La Fleur is one of the AMC Principal Investigators
Focus of research:

Our research aims to unravel the mechanistic link between diet composition and the development of obesity and diabetes as a first step towards a better understanding of the pathogenesis of Type 2 Diabetes Mellitus, focusing on the role of the brain.

 

AMC themes: Metabolic disorders and gastrointestinal diseases, Neurological & Psychiatric Disorders
Departments: Clinical Chemistry: Laboratory for Endocrinology, Internal Medicine: Endocrinology
Belegri E, Eggels L, Unmehopa UA, Mul JD, Boelen A, la Fleur SE, The effects of overnight nutrient intake on hypothalamic inflammation in a free-choice diet-induced obesity rat model. APPETITE 2017;ahead of print [PubMed]
Belegri E, Rijnsburger M, Eggels L, Unmehopa U, Scheper W, Boelen A, la Fleur SE, Effects of Fat and Sugar, Either Consumed or Infused toward the Brain, on Hypothalamic ER Stress Markers. FRONT NEUROSCI-SWITZ 2017;11:270 [PubMed]
Blancas-Velazquez A, la Fleur SE, Mendoza J, Effects of a free-choice high-fathigh-sugar diet on brain PER2 and BMAL1 protein expression in mice. APPETITE 2017;117:263-269 [PubMed]
Blancas-Velazquez A, Mendoza J, Garcia AN, la Fleur SE, Diet-Induced Obesity and Circadian Disruption of Feeding Behavior. FRONT NEUROSCI-SWITZ 2017;11:23 [PubMed]
Boumans IJMM, de Boer IJM, Hofstede GJ, la Fleur SE, Bokkers EAM, The importance of hormonal circadian rhythms in daily feeding patterns: An illustration with simulated pigs. HORM BEHAV 2017;93:82-93 [PubMed]
de Vries EM, Oosterman JE, Eggink HM, de Goede P, Sen S, Foppen E, Boudzovitch-Surovtseva O, Boelen A, Romijn JA, laFleur SE, Kalsbeek A, Effects of meal composition and meal timing on the expression of genes involved in hepatic drug metabolism in rats. PLOS ONE 2017;12 (10):e0185520 [PubMed]
Diepenbroek C. Glucose Metabolism, Diet Composition, and the Brain. S.l.: s.n.; 2017. 221p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Kalsbeek A; copromotor(s): La Fleur SE, Serlie MJ)
Diepenbroek C, Eggels L, Ackermans MT, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE, Differential effects of hypercaloric choice diets on insulin sensitivity in rats. J ENDOCRINOL 2017;232 (1):49-57 [PubMed]
Diepenbroek C, Rijnsburger M, Eggels L, van Megen KM, Ackermans MT, Fliers E, Kalsbeek A, Serlie MJ, La Fleur SE, Infusion of fluoxetine, a serotonin reuptake inhibitor, in the shell region of the nucleus accumbens increases blood glucose concentrations in rats. NEUROSCI LETT 2017;637:85-90 [PubMed]
Eggink HM, Oosterman JE, de Goede P, de Vries EM, Foppen E, Koehorst M, Groen AK, Boelen A, Romijn JA, la Fleur SE, Soeters MR, Kalsbeek A, Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats. CHRONOBIOL INT 2017;ahead of print [PubMed]
Rijnsburger M, Eggels L, Castel J, Cruciani-Guglielmacci C, Ackermans MT, Luquet S, La Fleur SE, A novel, double intra-carotid cannulation technique to study the effect of central nutrient sensing on glucose metabolism in the rat. J NEUROSCI METH 2017;290:79-84 [PubMed]
ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ, Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. CELL REP 2017;19 (10):1997-2004 [PubMed]
van der Harg JM, Eggels L, Bangel FN, Ruigrok SR, Zwart R, Hoozemans JJM, la Fleur SE, Scheper W, Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation. NEUROBIOL DIS 2017;103:163-173 [PubMed]
van Galen KA, ter Horst KW, Booij J, la Fleur SE, Serlie MJ, The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies. METABOLISM 2017;ahead of print [PubMed]
Versteeg RI. Brain, nutrition and metabolism: Studies in lean, obese and insulin resistant humans. S.l.: s.n.; 2017. 239p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E; copromotor(s): La Fleur SE, Serlie MJ)
Versteeg RI, Ackermans MT, Nederveen AJ, Fliers E, Serlie MJ, La Fleur SE, Meal timing effects on insulin sensitivity and intrahepatic triglycerides during weight loss. INT J OBESITY 2017;ahead of print [PubMed]
Versteeg RI, Koopman KE, Booij J, Ackermans MT, Unmehopa UA, Fliers E, la Fleur SE, Serlie MJ, Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans. NEUROENDOCRINOLOGY 2017;105 (2):141-149 [PubMed]
Versteeg RI, Schrantee A, Adriaanse SM, Unmehopa UA, Booij J, Reneman L, Fliers E, la Fleur SE, Serlie MJ, Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding. FASEB J 2017;31 (10):4545-4554 [PubMed]
Versteeg RI, Stenvers DJ, Visintainer D, Linnenbank A, Tanck MW, Zwanenburg G, Smilde AK, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE, Bisschop PH, Acute Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and Men with Type 2 Diabetes. J BIOL RHYTHM 2017;32 (2):130-142 [PubMed]
Yam KY, Naninck EFG, Abbink MR, La Fleur SE, Schipper L, van den Beukel JC, Grefhorst A, Oosting A, van der Beek EM, Lucassen PJ, Korosi A, Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice. PSYCHONEUROENDOCRINO 2017;77:186-195 [PubMed]
Gumbs MCR, van den Heuvel JK, la Fleur SE, The effect of obesogenic diets on brain Neuropeptide Y. PHYSIOL BEHAV 2016;162:161-173 [PubMed]
Koopman KE, Roefs A, Elbers DCE, Fliers E, Booij J, Serlie MJ, La Fleur SE, Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men. PSYCHOL MED 2016;46 (8):1707-1717 [PubMed]
Pandit R, Omrani A, Luijendijk MCM, de Vrind VAJ, van Rozen AJ, Oude Ophuis RJA, Garner K, Kallo I, Ghanem A, Liposits Z, Conzelmann KK, Vanderschuren LJMJ, la Fleur SE, Adan RAH, Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward. NEUROPSYCHOPHARMACOL 2016;41 (9):2241-2251 [PubMed]
Rijnsburger M, Belegri E, Eggels L, Unmehopa UA, Boelen A, Serlie MJ, la Fleur SE, The effect of diet interventions on hypothalamic nutrient sensing pathways in rodents. PHYSIOL BEHAV 2016;162:61-68 [PubMed]
ten Kulve JS, van Bloemendaal L, Balesar R, Ijzerman RG, Swaab DF, Diamant M, la Fleur SE, Alkemade A, Decreased Hypothalamic Glucagon-Like Peptide-1 Receptor Expression in Type 2 Diabetes Patients. J CLIN ENDOCR METAB 2016;101 (5):2122-2129 [PubMed]
ter Horst KW, Versteeg RI, Gilijamse PW, Ackermans MT, Heijboer AC, Romijn JA, La Fleur SE, Trinko R, DiLeone RJ, Serlie MJ, The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women. DIABETES METAB 2016;42 (6):416-423 [PubMed]
van der Zwaal EM, de Weijer BA, van de Giessen EM, Janssen I, Berends FJ, van de Laar A, Ackermans MT, Fliers E, la Fleur SE, Booij J, Serlie MJ, Striatal dopamine D-2/3 receptor availability increases after long-term bariatric surgery-induced weight loss. EUR NEUROPSYCHOPHARM 2016;26 (7):1190-1200 [PubMed]
Versteeg RI, Stenvers DJ, Kalsbeek A, Bisschop PH, Serlie MJ, la Fleur SE, Nutrition in the spotlight: metabolic effects of environmental light. P NUTR SOC 2016;75 (4):451-463 [PubMed]
Kalsbeek A, Su Y, Fliers E, La Fleur SE. The hypothalamo-pituitary-adrenal axis: circadian dysregulation and obesity in: Russell JA, Shipston MJ, editors. Neuroendocrinology of Stress. S.l.: Wiley-Blackwell; 2015., p. 219-243
Myers KP, la Fleur SE, Introduction to the Special Issue. PHYSIOL BEHAV 2015;152 (B):v-vi [PubMed]
Oosterman JE, Foppen E, van der Spek R, Fliers E, Kalsbeek A, la Fleur SE, Timing of fat and liquid sugar intake alters substrate oxidation and food efficiency in male Wistar rats. CHRONOBIOL INT 2015;32 (2):289-298 [PubMed]
Oosterman JE, Kalsbeek A, la Fleur SE, Belsham DD, Impact of nutrients on circadian rhythmicity. AM J PHYSIOL-REG I 2015;308 (5):R337-R350 [PubMed]
Pandit R. Of dieting and leptin. S.l.: s.n.; 2015. 266p. ISBN 978-90-393-6380-5 Proefschrift Universiteit Utrecht, Faculteit Geneeskunde. (Promotor(s): Adan RAH; copromotor(s): La Fleur SE)
Pandit R, van der Zwaal EM, Luijendijk MCM, Brans MAD, van Rozen AJ, Oude Ophuis RJA, Vanderschuren LJMJ, Adan RAH, la Fleur SE, Central melanocortins regulate the motivation for sucrose reward. PLOS ONE 2015;10 (3):e0121768 [PubMed]
van den Heuvel JK, Eggels L, van Rozen AJ, Fliers E, Kalsbeek A, Adan RAH, la Fleur SE, Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets. FRONT BEHAV NEUROSCI 2015;9:358 [PubMed]
van den Heuvel JK, Furman K, Gumbs MCR, Eggels L, Opland DM, Land BB, Kolk SM, S Narayanan N, Fliers E, Kalsbeek A, DiLeone RJ, la Fleur SE, Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. BIOL PSYCHIAT 2015;77 (7):633-641 [PubMed]
van der Harg JM, Eggels L, Ruigrok SR, Hoozemans JJM, la Fleur SE, Scheper W, Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation. FRONT NEUROSCI-SWITZ 2015;9:432 [PubMed]
Versteeg RI, Serlie MJ, Kalsbeek A, La Fleur SE, Serotonin, a possible intermediate between disturbed circadian rhythms and metabolic disease. NEUROSCIENCE 2015;301:155-167 [PubMed]
Yam KY, Schipper L, Naninck EFG, la Fleur SE, Oosting A, van der Beek EM, Lucassen PJ, Korosi A, Involvement of fat metabolism in the early-life stress induced cognitive impairments. PSYCHONEUROENDOCRINO 2015;61:34 [PubMed]
Zaaijer ER, de Bruin K, la Fleur SE, Goudriaan AE, van den Brink W, Booij J, Subchronic administration of short-acting naltrexone has no effect on striatal dopamine transporter availability, food intake or body weight gain in rats. J PSYCHOPHARMACOL 2015;29 (3):344-348 [PubMed]
Boender AJ, Koning NA, van den Heuvel JK, Luijendijk MCM, van Rozen AJ, la Fleur SE, Adan RAH, AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior. PLOS ONE 2014;9 (4):e94159 [PubMed]
Borgers AJ, Koopman KE, Bisschop PH, Serlie MJ, Swaab DF, Fliers E, la Fleur SE, Alkemade A, Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects. FRONT NEUROSCI-SWITZ 2014;8:106 [PubMed]
de Weijer BA, van de Giessen E, Janssen I, Berends FJ, van de Laar A, Ackermans MT, Fliers E, la Fleur SE, Booij J, Serlie MJ, Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity. DIABETOLOGIA 2014;57 (5):1078-1080 [PubMed]
Girault EM, Guigas B, Alkemade A, Foppen E, Ackermans MT, la Fleur SE, Fliers E, Kalsbeek A, Chronic treatment with olanzapine increases adiposity by changing fuel substrate and causes desensitization of the acute metabolic side effects. N-S ARCH PHARMACOL 2014;387 (2):185-195 [PubMed]
Kalsbeek A, La Fleur S, Fliers E, Circadian control of glucose metabolism. MOL METAB 2014;3 (4):372-383 [PubMed]
Koopman KE, Caan MWA, Nederveen AJ, Pels A, Ackermans MT, Fliers E, la Fleur SE, Serlie MJ, Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial. HEPATOLOGY 2014;60 (2):545-553 [PubMed]
Koopman KEM. Central serotonin and dopamine transporters in overeating, obesity and insulin resistance. Amsterdam: s.n.; 2014. 176p. ISBN 978-90-9028511-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fliers E, Booij J; copromotor(s): La Fleur SE, Serlie MJM)
La Fleur SE, Fliers E, Kalsbeek A, Neuroscience of glucose homeostasis. HANDB CLIN NEUROL 2014;126:341-351 [PubMed]
La Fleur SE, Fliers E, Kalsbeek A. Neuroscience of glucose homeostasis in: Zochodne DW, Malik RA, editors. Handbook of Clinical Neurology, Vol. 126 (3rd series). Toronto: Elsevier; 2014. -, p. 341-354
La Fleur SE, Luijendijk MCM, van der Zwaal EM, Brans MAD, Adan RAH, The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns. INT J OBESITY 2014;38 (5):643-649 [PubMed]
la Fleur SE, Serlie MJ, The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men. BEST PRACT RES CL EN 2014;28 (5):649-659 [PubMed]
Lammers NM, Sondermeijer BM, Twickler TBM, de Bie RM, Ackermans MT, Fliers E, Schuurman PR, la Fleur SE, Serlie MJ, Subthalamic nucleus stimulation does not influence basal glucose metabolism or insulin sensitivity in patients with Parkinson's disease. FRONT NEUROSCI-SWITZ 2014;8:95 [PubMed]
Pandit R, Luijendijk MCM, Vanderschuren LJMJ, la Fleur SE, Adan RAH, Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food. OBESITY 2014;22 (5):1216-1219 [PubMed]
van Bloemendaal L, ten Kulve JS, La Fleur SE, Ijzerman RG, Diamant M, Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS. J ENDOCRINOL 2014;221 (1):T1-T16 [PubMed]
van den Heuvel JK. Neural pathways controlling homeostatic and hedonic feeding in rats on free-choice diets. S.l.: s.n.; 2014. 168p. ISBN 9789461824660 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kalsbeek A, Fliers E; copromotor(s): La Fleur SE)
van den Heuvel JK, Eggels L, Fliers E, Kalsbeek A, Adan RAH, la Fleur SE, Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet. PLOS ONE 2014;9 (1):e87729 [PubMed]
van den Heuvel JK, Eggels L, van Rozen AJ, Luijendijk MCM, Fliers E, Kalsbeek A, Adan RAH, La Fleur SE, Neuropeptide Y and leptin sensitivity is dependent on diet composition. J NEUROENDOCRINOL 2014;26 (6):377-385 [PubMed]
van der Zwaal EM, Janhunen SK, La Fleur SE, Adan RAH, Modelling olanzapine-induced weight gain in rats. INT J NEUROPSYCHOPH 2014;17 (1):169-186 [PubMed]
Bruinstroop E, la Fleur SE, Ackermans MT, Foppen E, Wortel J, Kooijman S, Berbée JFP, Rensen PCN, Fliers E, Kalsbeek A, The autonomic nervous system regulates postprandial hepatic lipid metabolism. AM J PHYSIOL-ENDOC M 2013;304 (10):E1089-E1096 [PubMed]
Diepenbroek C, Serlie MJ, Fliers E, Kalsbeek A, la Fleur SE, Brain areas and pathways in the regulation of glucose metabolism. BIOFACTORS 2013;39 (5):505-513 [PubMed]
Diepenbroek C, van der Plasse G, Eggels L, Rijnsburger M, Feenstra MGP, Kalsbeek A, Denys D, Fliers E, Serlie MJ, la Fleur SE, Alterations in blood glucose and plasma glucagon concentrations during deep brain stimulation in the shell region of the nucleus accumbens in rats. FRONT NEUROSCI-SWITZ 2013;7:226 [PubMed]
Girault EM. The role of hypothalamic pathways in the metabolic side effects of Olanzapine. s.l.: s.n.; 2013. 156p. ISBN 9789088917352 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kalsbeek A, Fliers E; copromotor(s): La Fleur SE)
Girault EM, Toonen PW, Eggels L, Foppen E, Ackermans MT, la Fleur SE, Fliers E, Kalsbeek A, Olanzapine-induced changes in glucose metabolism are independent of the melanin-concentrating hormone system. PSYCHONEUROENDOCRINO 2013;38 (11):2640-2646 [PubMed]
Koopman KE, Booij J, Fliers E, Serlie MJ, la Fleur SE, Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region. MOL METAB 2013;2 (4):417-422 [PubMed]
La Fleur SE, Kalsbeek A. Does Chronodisruption Play a Role? in: Garaulet M, Ordovas J, editors. Chronobiology and Obesity. New York: Springer New York; 2012., p. 111-131
Pandit R, La Fleur SE, Adan RAH, The role of melanocortins and Neuropeptide Y in food reward. EUR J PHARMACOL 2013;719 (1-3):208-214 [PubMed]
Stenvers DJ, DeVries JH, la Fleur SE, What's the Time? Does the Artificial Pancreas Need to Know?. DIABETES 2013;62 (7):2173-2174 [PubMed]
van de Giessen E, La Fleur SE, Eggels L, de Bruin K, van den Brink W, Booij J, High fat/carbohydrate ratio but not total energy intake induces lower striatal dopamine D2/3 receptor availability in diet-induced obesity. INT J OBESITY 2013;37 (5):754-757 [PubMed]
van der Zwaal EM, La Fleur SE. Genetics of Satiety in: Blundell J, Bellisle F, editors. Satiation, satiety and the control of food intake. S.l.: Woodhead publishing; 2013., p. 55-74
Alkemade A, Yi CX, Pei L, Harakalova M, Swaab DF, la Fleur SE, Fliers E, Kalsbeek A, AgRP and NPY Expression in the Human Hypothalamic Infundibular Nucleus Correlate with Body Mass Index, Whereas Changes in alpha MSH Are Related to Type 2 Diabetes. J CLIN ENDOCR METAB 2012;97 (6):E925-E933 [PubMed]
Koopman KE, la Fleur SE, Fliers E, Serlie MJ, Booij J, Assessing the Optimal Time Point for the Measurement of Extrastriatal Serotonin Transporter Binding with I-123-FP-CIT SPECT in Healthy, Male Subjects. J NUCL MED 2012;53 (7):1087-1090 [PubMed]
La Fleur SE, Kalsbeek A. Chapter 7: Increased Risk of Diabetes due to Obesity: Does Chronodisruption Play a Role? in: Garaulet M, Ordovas J, editors. Chronobiology and Obesity. New York: Springer New York; 2012., p. 111-131
Pandit R, Mercer JG, Overduin J, la Fleur SE, Adan RAH, Dietary Factors Affect Food Reward and Motivation to Eat. OBESITY FACTS 2012;5 (2):221-242 [PubMed]
van de Giessen E. Neurobiological aspects of obesity: dopamine, srotonin, and imaging. s.l.: s.n.; 2012. 302p. ISBN 9789461821706 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Booij J, van den Brink W; copromotor(s): Baas F, La Fleur SE)
van de Giessen E, de Bruin K, la Fleur SE, van den Brink W, Booij J, Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese rats. EUR NEUROPSYCHOPHARM 2012;22 (4):290-299 [PubMed]
van de Giessen E, la Fleur SE, de Bruin K, van den Brink W, Booij J, Free-Choice and No-Choice High-Fat Diets Affect Striatal Dopamine D-2/3 Receptor Availability, Caloric Intake, and Adiposity. OBESITY 2012;20 (8):1738-1740 [PubMed]
van der Zwaal EM, Janhunen SK, Luijendijk MCM, Baclesanu R, Vanderschuren LJMJ, Adan RAH, la Fleur SE, Olanzapine and sibutramine have opposing effects on the motivation for palatable food. BEHAV PHARMACOL 2012;23 (2):198-204 [PubMed]
van der Zwaal EM, Merkestein M, Lam YK, Brans MAD, Luijendijk MCM, Bok LIH, Verheij ER, La Fleur SE, Adan RAH, The acute effects of olanzapine on ghrelin secretion, CCK sensitivity, meal size, locomotor activity and body temperature. INT J OBESITY 2012;36 (2):254-261 [PubMed]
Yi CX, Foppen E, Abplanalp W, Gao Y, Alkemade A, la Fleur SE, Serlie MJ, Fliers E, Buijs RM, Tschöp MH, Kalsbeek A, Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity. DIABETES 2012;61 (2):339-345 [PubMed]
de Backer MWA, la Fleur SE, Adan RAH, Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner. EUR J PHARMACOL 2011;660 (1):148-155 [PubMed]
de Backer MWA, La Fleur SE, Brans MAD, van Rozen AJ, Luijendijk MCM, Merkestein M, Garner KM, van der Zwaal EM, Adan RAH, Melanocortin receptor-mediated effects on obesity are distributed over specific hypothalamic regions. INT J OBESITY 2011;35 (5):629-641 [PubMed]
Janhunen SK, van der Zwaal EM, la Fleur SE, Adan RAH, Inverse agonism at α2A adrenoceptors augments the hypophagic effect of sibutramine in rats. OBESITY 2011;19 (10):1979-1986 [PubMed]
Kalsbeek A, Chun-Xia Y, La Fleur S, Fliers E, De rol van de biologische klok en het autonome zenuwstelsel bij wakker worden. NEUROPRAXIS 2011;15:159-171
Kalsbeek A, Scheer FA, Perreau-Lenz S, la Fleur SE, Yi CX, Fliers E, Buijs RM, Circadian disruption and SCN control of energy metabolism. FEBS LETT 2011;585 (10):1412-1426 [PubMed]
Kalsbeek A, Yi CX, Cailotto C, la Fleur SE, Fliers E, Buijs RM, Mammalian clock output mechanisms. ESSAYS BIOCHEM 2011;49 (1):137-151 [PubMed]
La Fleur SE, Luijendijk MCM, van Rozen AJ, Kalsbeek A, Adan RAH, A free-choice high-fat high-sugar diet induces glucose intolerance and insulin unresponsiveness to a glucose load not explained by obesity. INT J OBESITY 2011;35 (4):595-604 [PubMed]
Mul JD, la Fleur SE, Toonen PW, Afrasiab-Middelman A, Binnekade R, Schetters D, Verheij MMM, Sears RM, Homberg JR, Schoffelmeer ANM, Adan RAH, DiLeone RJ, de Vries TJ, Cuppen E, Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat. PLOS ONE 2011;6 (5):e19600 [PubMed]
Serlie MJ, La Fleur SE, Fliers E, Obesity: is evolution to blame?. NETH J MED 2011;69 (4):156-158 [PubMed]
van den Heuvel JK, van Rozen AJ, Adan RAH, la Fleur SE, An overview on how components of the melanocortin system respond to different high energy diets. EUR J PHARMACOL 2011;660 (1):207-212 [PubMed]
van der Zwaal EM. Lessons learned from developing animal models. Utrecht: s.n.; 2011. -p. Proefschrift Universiteit Utrecht, Faculteit Geneeskunde. (Promotor(s): Adan RAH; copromotor(s): La Fleur SE)
de Backer MWA, Brans MAD, van Rozen AJ, van der Zwaal EM, Luijendijk MCM, Garner KG, de Krom M, van Beekum O, La Fleur SE, Adan RAH, Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balance. J MOL ENDOCRINOL 2010;45 (5):341-353 [PubMed]
Homberg JR, la Fleur SE, Cuppen E, Serotonin transporter deficiency increases abdominal fat in female, but not male rats. OBESITY 2010;18 (1):137-145 [PubMed]
Kalsbeek A, Bruinstroop E, Yi CX, Klieverik LP, La Fleur SE, Fliers E, Hypothalamic control of energy metabolism via the autonomic nervous system. ANN NY ACAD SCI 2010;1212 (1):114-129 [PubMed]
Kalsbeek A, Yi CX, la Fleur SE, Buijs RM, Fliers E, SUPRACHIASMATIC NUCLEUS AND AUTONOMIC NERVOUS SYSTEM INFLUENCES ON AWAKENING FROM SLEEP. INT REV NEUROBIOL 2010;93:91-107 [PubMed]
Kalsbeek A, Yi CX, la Fleur SE, Fliers E, The hypothalamic clock and its control of glucose homeostasis. TRENDS ENDOCRIN MET 2010;21 (7):402-410 [PubMed]
La Fleur SE, van Rozen AJ, Luijendijk MCM, Groeneweg F, Adan RAH, A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia. INT J OBESITY 2010;34 (3):537-546 [PubMed]
Luijendijk MCM, Brakkee JH, Boskovic E, van den Vosse R, Ligtvoet CM, La Fleur SE, van der Zwaal EM, Adan RAH, Weet hoe je dier eet! Automatische registratie van voedselpatronen.. BIOTECHNIEK 2010;49 (4):.
Mul JD, Yi CX, van den Berg SAA, Ruiter M, Toonen PW, van der Elst MCJ, Voshol PJ, Ellenbroek BA, Kalsbeek A, la Fleur SE, Cuppen E, Pmch expression during early development is critical for normal energy homeostasis. AM J PHYSIOL-ENDOC M 2010;298 (3):E477-E488 [PubMed]
van der Zwaal EM, Luijendijk MCM, Evers SS, la Fleur SE, Adan RAH, Olanzapine affects locomotor activity and meal size in male rats. PHARMACOL BIOCHEM BE 2010;97 (1):130-137 [PubMed]
Yi CX, la Fleur SE, Fliers E, Kalsbeek A, The role of the autonomic nervous liver innervation in the control of energy metabolism. BBA-MOL BASIS DIS 2010;1802 (4):416-431 [PubMed]
de Krom M, Bauer F, Collier D, Adan RAH, la Fleur SE, Genetic variation and effects on human eating behavior. ANNU REV NUTR 2009;29:283-304 [PubMed]
Tiesjema B, la Fleur SE, Luijendijk MCM, Adan RAH, Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake. OBESITY 2009;17 (7):1448-1450 [PubMed]
Adan RAH, Vanderschuren LJMJ, la Fleur SE, Anti-obesity drugs and neural circuits of feeding. TRENDS PHARMACOL SCI 2008;29 (4):208-217 [PubMed]
van der Zwaal EM, Luijendijk MCM, Adan RAH, la Fleur SE, Olanzapine-induced weight gain: chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution. EUR J PHARMACOL 2008;585 (1):130-136 [PubMed]
Dallman MF, Akana SF, Pecoraro NC, Warne JP, la Fleur SE, Foster MT, Glucocorticoids, the etiology of obesity and the metabolic syndrome. CURR ALZHEIMER RES 2007;4 (2):199-204 [PubMed]
La Fleur SE, Vanderschuren LJMJ, Luijendijk MC, Kloeze BM, Tiesjema B, Adan RAH, A reciprocal interaction between food-motivated behavior and diet-induced obesity. INT J OBESITY 2007;31 (8):1286-1294 [PubMed]
Tiesjema B, Adan RAH, Luijendijk MCM, Kalsbeek A, la Fleur SE, Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior. J NEUROSCI 2007;27 (51):14139-14146 [PubMed]
Tiesjema B, la Fleur SE, Luijendijk MCM, Brans MAD, Lin EJD, During MJ, Adan RA, Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesity. OBESITY 2007;15 (10):2424-2435 [PubMed]
Adan RAH, Tiesjema B, Hillebrand JJG, La Fleur SE, Kas MJH, de Krom M, The MC4 receptor and control of appetite. BRIT J PHARMACOL 2006;149 (7):815-827 [PubMed]
Dallman MF, Pecoraro NC, la Fleur SE, Warne JP, Ginsberg AB, Akana SF, Laugero KC, Houshyar H, Strack AM, Bhatnagar S, Bell ME, Glucocorticoids, chronic stress, and obesity. PROG BRAIN RES 2006;153:75-105 [PubMed]
Kalsbeek A, Palm IF, La Fleur SE, Scheer FAJL, Perreau-Lenz S, Ruiter M, Kreier F, Cailotto C, Buijs RM, SCN outputs and the hypothalamic balance of life. J BIOL RHYTHM 2006;21 (6):458-469 [PubMed]
Kalsbeek A, Ruiter M, La Fleur SE, Cailotto C, Kreier F, Buijs RM, The hypothalamic clock and its control of glucose homeostasis. PROG BRAIN RES 2006;153:283-307 [PubMed]
la Fleur SE, The effects of glucocorticoids on feeding behavior in rats. PHYSIOL BEHAV 2006;89 (1):110-114 [PubMed]
Pecoraro N, Dallman MF, Warne JP, Ginsberg AB, Laugero KD, la Fleur SE, Houshyar H, Gomez F, Bhargava A, Akana SF, From Malthus to motive: how the HPA axis engineers the phenotype, yoking needs to wants. PROG NEUROBIOL 2006;79 (5-6):247-340 [PubMed]
Pecoraro N, Ginsberg AB, Warne JP, Gomez F, la Fleur SE, Dallman MF, Diverse basal and stress-related phenotypes of Sprague Dawley rats from three vendors. PHYSIOL BEHAV 2006;89 (4):598-610 [PubMed]
Cailotto C, la Fleur SE, van Heijningen C, Wortel J, Kalsbeek A, Feenstra M, Pévet P, Buijs RM, The suprachiasmatic nucleus controls the daily variation of plasma glucose via the autonomic output to the liver: are the clock genes involved?. EUR J NEUROSCI 2005;22 (10):2531-2540 [PubMed]
Dallman MF, Pecoraro NC, la Fleur SE, Chronic stress and comfort foods: self-medication and abdominal obesity. BRAIN BEHAV IMMUN 2005;19 (4):275-280 [PubMed]
Gomez F, la Fleur SE, Weiner RI, Dallman MF, El Majdoubi M, Decreased gonadotropin-releasing hormone neuronal activity is associated with decreased fertility and dysregulation of food intake in the female GPR-4 transgenic rat. ENDOCRINOLOGY 2005;146 (9):3800-3808 [PubMed]
la Fleur SE, Houshyar H, Roy M, Dallman MF, Choice of lard, but not total lard calories, damps adrenocorticotropin responses to restraint. ENDOCRINOLOGY 2005;146 (5):2193-2199 [PubMed]
la Fleur SE, Manalo SL, Roy M, Houshyar H, Dallman MF, Hepatic vagotomy alters limbic and hypothalamic neuropeptide responses to insulin-dependent diabetes and voluntary lard ingestion. EUR J NEUROSCI 2005;21 (10):2733-2742 [PubMed]
la Fleur SE, Wick EC, Idumalla PS, Grady EF, Bhargava A, Role of peripheral corticotropin-releasing factor and urocortin II in intestinal inflammation and motility in terminal ileum. P NATL ACAD SCI USA 2005;102 (21):7647-7652 [PubMed]
Pecoraro N, Gomez F, La Fleur S, Roy M, Dallman MF, Single, but not multiple pairings of sucrose and corticosterone enhance memory for sucrose drinking and amplify remote reward relativity effects. NEUROBIOL LEARN MEM 2005;83 (3):188-195 [PubMed]
Dallman MF, Akana SF, Strack AM, Scribner KS, Pecoraro N, La Fleur SE, Houshyar H, Gomez F, Chronic stress-induced effects of corticosterone on brain: direct and indirect. ANN NY ACAD SCI 2004;1018:141-150 [PubMed]
Dallman MF, la Fleur SE, Pecoraro NC, Gomez F, Houshyar H, Akana SF, Minireview: glucocorticoids--food intake, abdominal obesity, and wealthy nations in 2004. ENDOCRINOLOGY 2004;145 (6):2633-2638 [PubMed]
Kalsbeek A, La Fleur S, van Heijningen C, Buijs RM, Suprachiasmatic GABAergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J NEUROSCI 2004;24 (35):7604-7613 [PubMed]
la Fleur SE, Akana SF, Manalo SL, Dallman MF, Interaction between corticosterone and insulin in obesity: regulation of lard intake and fat stores. ENDOCRINOLOGY 2004;145 (5):2174-2185 [PubMed]
Buijs RM, la Fleur SE, Wortel J, van Heyningen C, Zuiddam L, Mettenleiter TC, Kalsbeek A, Nagai K, Niijima A, The Suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J COMP NEUROL 2003;464 (1):36-48 [PubMed]
Dallman MF, Pecoraro N, Akana SF, la Fleur SE, Gomez F, Houshyar H, Bell ME, Bhatnagar S, Laugero KD, Manalo S, Chronic stress and obesity: a new view of "comfort food". P NATL ACAD SCI USA 2003;100 (20):11696-11701 [PubMed]
Kalsbeek A, Ruiter M, La Fleur SE, van Heijningen C, Buijs RM, The diurnal modulation of hormonal responses in the rat varies with different stimuli. J NEUROENDOCRINOL 2003;15 (12):1144-1155 [PubMed]
La Fleur SE, Daily rhythms in glucose metabolism: suprachiasmatic nucleus output to peripheral tissue. J NEUROENDOCRINOL 2003;15 (3):315-322 [PubMed]
la Fleur SE, Ji H, Manalo SL, Friedman MI, Dallman MF, The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia. DIABETES 2003;52 (9):2321-2330 [PubMed]
Ruiter M, la Fleur SE, van Heijningen C, van der Vliet J, Kalsbeek A, Buijs RM, The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior. DIABETES 2003;52 (7):1709-1715 [PubMed]
Kalsbeek A, Fliers E, Romijn JA, La Fleur SE, Wortel J, Bakker O, Endert E, Buijs RM, The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. ENDOCRINOLOGY 2001;142 (6):2677-2685 [PubMed]
La Fleur SE, Kalsbeek A, Wortel J, Fekkes ML, Buijs RM, A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus. DIABETES 2001;50 (6):1237-1243 [PubMed]
La Fleur SE, Kalsbeek A, Wortel J, van der Vliet J, Buijs RM, Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night-time glucose concentrations. J NEUROENDOCRINOL 2001;13 (12):1025-1032 [PubMed]
La Fleur SE, Kalsbeek A, Wortel J, Buijs RM, Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver. BRAIN RES 2000;871 (1):50-56 [PubMed]
La Fleur SE, Kalsbeek A, Wortel J, Buijs RM, A suprachiasmatic nucleus generated rhythm in basal glucose concentrations. J NEUROENDOCRINOL 1999;11 (8):643-652 [PubMed]
Douma BR, Korte SM, Buwalda B, La Fleur SE, Bohus B, Luiten PG, Repeated blockade of mineralocorticoid receptors, but not of glucocorticoid receptors impairs food rewarded spatial learning. PSYCHONEUROENDOCRINO 1998;23 (1):33-44 [PubMed]
Steimer T, la Fleur S, Schulz PE, Neuroendocrine correlates of emotional reactivity and coping in male rats from the Roman high (RHA/Verh)- and low (RLA/Verh)-avoidance lines. BEHAV GENET 1997;27 (6):503-512 [PubMed]
Key publications

Koopman KE, Roefs A, Elbers DCE, Fliers E, Booij J, Serlie MJ, La Fleur SE, Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men. PSYCHOL MED 2016;46 (8):1707-1717 [PubMed]
van den Heuvel JK, Furman K, Gumbs MCR, Eggels L, Opland DM, Land BB, Kolk SM, S Narayanan N, Fliers E, Kalsbeek A, DiLeone RJ, la Fleur SE, Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. BIOL PSYCHIAT 2015;77 (7):633-641 [PubMed]
La Fleur SE, Luijendijk MCM, van der Zwaal EM, Brans MAD, Adan RAH, The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns. INT J OBESITY 2014;38 (5):643-649 [PubMed]
Koopman KE, Caan MWA, Nederveen AJ, Pels A, Ackermans MT, Fliers E, la Fleur SE, Serlie MJ, Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial. HEPATOLOGY 2014;60 (2):545-553 [PubMed]
Koopman KE, Booij J, Fliers E, Serlie MJ, la Fleur SE, Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region. MOL METAB 2013;2 (4):417-422 [PubMed]


All Publications

Curriculum Vitae

Grants and Honors (selection)

2016    NWO-VICI grant "To be ready or not for glucose challenges; a critical role for the brain's reward center"

2012    STW open competition grant 'Nutrients to modulate obesity-associated brain inflammation'

2012     STW perspective grant  'Enlightened Meals'

2008    ZonMW-VIDI grant “Brain mediators in obesity and insulin resistance”

2008    Alan N. Epstein Research Award, Society for the Study of Ingestive Behavior

2004    ZonMW-VENI grant “The hepatic vagus and the melanocortin system in diet-induced obesity”

2002    Novo Nordisk Award for Endocrinology

 

Research Experience

02/2017- present

Professor, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

10/2016- present

Honorary group leader, Metabolism and Reward Group, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam, the Netherlands

11/2014-05/2015

Visiting Professor, Unit of Functional and Adaptive Biology, CNRS-UNiversite Paris Diderot-Paris 7, Paris, France

07/2011-02/2017

Associate Professor, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

12/2008- 7/2011

Group leader/Scientific Staff Member, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

11/2004-12/2008

Postdoc/Assistant Professor, Dept. Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

8/2001- 11/2004

Postdoctoral fellow, Dept. Physiology, University of California San Francisco, San Francisco, USA.  supervisor: Prof. dr. Mary F Dallman

3/1997 – 8/2001

PhD student (OIO), Netherlands Institute for Brain Research, Amsterdam, the Netherlands. Supervisors: dr. A Kalsbeek & Prof. dr. RM Buijs

 

Education

2001

PhD degree in Neuroscience. Thesis title: “The Suprachiasmatic Nucleus Generated Rhythm in Blood   Glucose; a Role for the Autonomic Nervous System” Supervisors: Dr. A. Kalsbeek & Prof. dr. R.M. Buijs (Netherlands Institute for Brain Research, Amsterdam, the Netherlands) Thesis defense: 14/06/2001, University of Amsterdam, the Netherlands

1997         

Master’s degree (‘doctoraal’) in (Medical) Biology, University of Groningen, The Netherlands
 

Research programmes

Brain mediators in diet-induced obesity and diabetes

Type 2 Diabetes Mellitus is a rapidly growing epidemic. Obesity has been identified as one of the main risks for this disease and increased intake of saturated fat and sugar increases the risk to develop Obesity and Type 2 Diabetes Mellitus. Our first interest is to understand how nutrients affect the brain and how these changes mediate the overeating as observed in (most) obese people. Secondly, although peripheral actions of both fat and sugar will affect glucose metabolism, it does not explain why some obese individuals become diabetic and why others do not. We therefore focus on the effects of nutrients on the brain as an alternative route via which high caloric diets might mediate the development of diabetes.

We study these research questions with a translational approach using both diet-induced obese animals and human experimental studies. This translational approach is possible because of a close collaboration with the group of dr MJ Serlie within the Department of Endocrinology and Metabolism and the group of Prof dr J Booij from the Department of Nuclear Medicine.

Faculty
Prof. dr. S.E. La Fleur

Postdocs
A.N. Garcia PhD
Dr. J.D. Mul

PhD Students
E. Belegri MSc
K.A. van Galen
M.C. Gumbs MSc
Drs. M. Kiliçarslan
L.L. Koekkoek
M. Rijnsburger MSc
A.S. Blancas Velázquez MSc (University of Strasbourg, France)
C.G. de Git MSc (Utrecht University)
A. Joshi MSc (University of Strasbourg, France)
M. Ugur MSc (University of Strasbourg, France)
S.R. Ursem (VUMC)

Others
L. Eggels BSc
K. Lamuadni
U.A. Unmehopa BSc

Other research related activities
  • Membership of editorial board / Editorship, APPETITE
  • Membership of editorial board / Editorship, JOURNAL OF NEUROENDOCRINOLOGY
  • Membership of editorial board / Editorship, FRONTIERS IN NEUROSCIENCE
  • Membership of advisory board / Consultant, NWO: Netherlands Organisation
  • Membership of advisory board / Consultant, ERC (European Research Council)
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • NWO
  • Technologiestichting STW
  • Universiteit Maastricht