• Male

Dr. ir. P.D. Moerland

Position: Scientific staff member (UD)
Main activities: Research, Teaching
Specialisation: Bioinformatics, systems genomics
foto
Focus of research:

Bioinformatics and systems genomics. See http://www.bioinformaticslaboratory.nl/foswiki/bin/view/BioLab/SystemsGenomicsBioLab.

AMC themes: Infection & Immunity, Public Health & Epidemiology
Departments: Clinical Epidemiology, Biostatistics and Bioinformatics
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Boekel J, Chilton JM, Cooke IR, Horvatovich PL, Jagtap PD, Käll L, Lehtiö J, Lukasse P, Moerland PD, Griffin TJ, Multi-omic data analysis using Galaxy. NAT BIOTECHNOL 2015;33 (2):137-139 [PubMed]
Braga FAV, Hertoghs KML, Kragten NAM, Doody GM, Barnes NA, Remmerswaal EBM, Hsiao CC, Moerland PD, Wouters D, Derks IAM, van Stijn A, Demkes M, Hamann J, Eldering E, Nolte MA, Tooze RM, ten Berge IJM, van Gisbergen KPJM, van Lier RAW, The Blimp-1 homologue Hobit identifies effector-type lymphocytes in humans. EUR J IMMUNOL 2015;ahead of print [PubMed]
Jebbink JM, Boot RG, Keijser R, Moerland PD, Aten J, Veenboer GJM, van Wely M, Buimer M, Ver Loren van Themaat E, Aerts JMFG, van der Post JAM, Afink GB, Ris-Stalpers C, Increased glucocerebrosidase expression and activity in preeclamptic placenta. PLACENTA 2015;36 (2):160-169 [PubMed]
Jebbink JM, Boot RG, Keijser R, Moerland PD, Aten J, Veenboer GJ, van Wely M, Buimer M, Ver Loren van Themaat E, Aerts JM, van der Post JA, Afink GB, Ris-Stalpers C, [271-POS]: Glucocerebrosidase expression and activity in human placenta from normotensive and preeclamptic pregnancies. PREGNANCY HYPERTENS 2015;5 (1):135-136 [PubMed]
Kok MGM, Halliani A, Moerland PD, Meijers JCM, Creemers EE, Pinto-Sietsma SJ, Normalization panels for the reliable quantification of circulating microRNAs by RT-qPCR. FASEB J 2015;ahead of print [PubMed]
Kurakula K, Sommer D, Sokolovic M, Moerland PD, Scheij S, van Loenen PB, Koenis DS, Zelcer N, van Tiel CM, de Vries CJM, LIM-Only Protein FHL2 Is a Positive Regulator of Liver X Receptors in Smooth Muscle Cells Involved in Lipid Homeostasis. MOL CELL BIOL 2015;35 (1):52-62 [PubMed]
Nandal UK, Vlietstra WJ, Byrman C, Jeeninga RE, Ringrose JH, van Kampen AHC, Speijer D, Moerland PD, Candidate prioritization for low-abundant differentially expressed proteins in 2D-DIGE datasets. BMC BIOINFORMATICS 2015;16 (1):25 [PubMed]
Sontrop HMJ. A Critical Perspective On Microarray Breast Cancer Gene Expression Profiling. S.l.: s.n.; 2015. 194p. ISBN 978-94-6295-075-7 Proefschrift Technische Universiteit Delft, -. (Promotor(s): Reinders MJT; copromotor(s): Moerland PD)
te Raa GD, Derks IAM, Navrkalova V, Skowronska A, Moerland PD, van Laar J, Oldreive C, Monsuur H, Trbusek M, Malcikova J, Lodén M, Geisler CH, Hüllein J, Jethwa A, Zenz T, Pospisilova S, Stankovic T, van Oers MHJ, Kater AP , Eldering E, The impact of SF3B1 mutations in CLL on the DNA-damage response. LEUKEMIA 2015;29 (5):1133-1142 [PubMed]
van der Meer AJ, Scicluna BP, Moerland PD, Lin J, Jacobson EW, Vlasuk GP, van der Poll T, The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans. CRIT CARE MED 2015;43 (6):e199-e202 [PubMed]
van Uitert M, Moerland PD, Enquobahrie DA, Laivuori H, van der Post JAM, Ris-Stalpers C, Afink GB, Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia. PLOS ONE 2015;10 (7):e0132468 [PubMed]
Kerami Z, Duijvis NW , Vogels EW, van Dooren FH, Moerland PD, te Velde AA, Effect of interleukin-17 on gene expression profile of fibroblasts from Crohn's disease patients. J CROHNS COLITIS 2014;8 (10):1208-1216 [PubMed]
Koopmann TT, Adriaens ME, Moerland PD, Marsman RF, Westerveld ML, Lal S, Zhang T, Simmons CQ, Baczko I, Dos Remedios C, Bishopric NH, Varro A, George AL Jr, Lodder EM, Bezzina CR, Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart. PLOS ONE 2014;9 (5):e97380 [PubMed]
Lodder EM, Scicluna BP, Beekman L, Arends D, Moerland PD, Tanck MWT, Adriaens ME, Bezzina CR, Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. CIRC-CARDIOVASC GENE 2014;7 (6):790-798 [PubMed]
Stobbe MD, Jansen GA, Moerland PD, van Kampen AHC, Knowledge representation in metabolic pathway databases. BRIEF BIOINFORM 2014;15 (3):455-470 [PubMed]
van Oorschot B, Hovingh SE, Moerland PD, Medema JP, Stalpers LJA, Vrieling H, Franken NAP, Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity. INT J RADIAT ONCOL 2014;88 (3):664-670 [PubMed]
Wegdam W, Argmann CA, Kramer G, Vissers JP, Buist MR, Kenter GG, Aerts JMFG, Meijer D, Moerland PD, Label-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors. PLOS ONE 2014;9 (9):e108046-(12 p.) [PubMed]
Bergonzi S, Albani MC, Ver Loren van Themaat E, Nordström KJV, Wang R, Schneeberger K, Moerland PD, Coupland G, Mechanisms of Age-Dependent Response to Winter Temperature in Perennial Flowering of Arabis alpina. SCIENCE 2013;340 (6136):1094-1097 [PubMed]
Kleinrouweler CE, van Uitert M, Moerland PD, Ris-Stalpers C, van der Post JAM, Afink GB, Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis. PLOS ONE 2013;8 (7):e68991 [PubMed]
McClellan EA, Moerland PD, van der Spek PJ, Stubbs AP, NetWeAvers: an R package for integrative biological network analysis with mass spectrometry data. BIOINFORMATICS 2013;29 (22):2946-2947 [PubMed]
Stobbe MD, Swertz MA, Thiele I, Rengaw T, van Kampen AHC, Moerland PD, Consensus and conflict cards for metabolic pathway databases. BMC SYST BIOL 2013;7 (1):50 [PubMed]
Helbig C, Gentek R, Backer RA, de Souza Y, Derks IAM, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D, Notch controls the magnitude of T helper cell responses by promoting cellular longevity. P NATL ACAD SCI USA 2012;109 (23):9041-9046 [PubMed]
Kramer G, Moerland PD, Jeeninga RE, Vlietstra WJ, Ringrose JH, Byrman C, Berkhout B, Speijer D, Proteomic analysis of HIV-T cell interaction: an update. FRONT MICROBIOL 2012;3:240-(6 p.) [PubMed]
Lodder EM, Scicluna BP, Milano A, Sun AY, Tang H, Remme CA, Moerland PD, Tanck MWT, Pitt GS, Marchuk DA, Bezzina CR, Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction. PLOS GENET 2012;8 (12):e1003113 [PubMed]
Stobbe MD. The road to knowledge: from biology to databases and back again. s.l.: s.n.; 2012. 168p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Kampen AHC; copromotor(s): Moerland PD)
Stobbe MD, Houten SM, van Kampen AHC, Wanders RJA, Moerland PD, Improving the description of metabolic networks: the TCA cycle as example. FASEB J 2012;26 (9):3625-3636 [PubMed]
Wegdam W, Moerland PD, Meijer D, de Jong SM, Hoefsloot HCJ, Kenter GG, Buist MR, Aerts JMFG, A critical assessment of SELDI-TOF-MS for biomarker discovery in serum and tissue of patients with an ovarian mass. PROTEOME SCI 2012;10 (1):45-(10 p.) [PubMed]
Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF 3rd, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB, Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages. VIROLOGY 2011;420 (1):32-42 [PubMed]
Bol SM, Moerland PD, Limou S, van Remmerden Y, Coulonges C, van Manen D, Herbeck JT, Fellay J, Sieberer M, Sietzema JG, van 't Slot R, Martinson J, Zagury JF, Schuitemaker H, van 't Wout AB, Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages. PLOS ONE 2011;6 (2):e17190 [PubMed]
Hakvoort TBM, Moerland PD, Frijters R, Sokolovic A, Labruyere WT, Vermeulen JLM, Ver Loren van Themaat E, Breit TM, Wittink FRA, van Kampen AHC, Verhoeven AJ, Lamers WH, Sokolovic M, Interorgan Coordination of the Murine Adaptive Response to Fasting. J BIOL CHEM 2011;286 (18):16332-16343 [PubMed]
Noordhuis MG, Fehrmann RSN, Wisman GBA, Nijhuis ER, van Zanden JJ, Moerland PD, Ver Loren van Themaat E, Volders HH, Kok M, ten Hoor KA, Hollema H, de Vries EGE, de Bock GH, van der Zee AGJ, Schuuring E, Involvement of the TGF-beta and beta-Catenin Pathways in Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer. CLIN CANCER RES 2011;17 (6):1317-1330 [PubMed]
Sondermeijer BM, Bakker A, Halliani A, de Ronde MWJ, Marquart AA, Tijsen AJ, Mulders TA, Kok MGM, Battjes S, Maiwald S, Sivapalaratnam S, Trip MD, Moerland PD, Meijers JCM, Creemers EE, Pinto-Sietsma SJ, Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*. PLOS ONE 2011;6 (10):e25946 [PubMed]
Sontrop HMJ, Verhaegh WFJ, Reinders MJT, Moerland PD, An evaluation protocol for subtype-specific breast cancer event prediction. PLOS ONE 2011;6 (7):e21681 [PubMed]
Stobbe MD, Houten SM, Jansen GA, van Kampen AHC, Moerland PD, Critical assessment of human metabolic pathway databases: a stepping stone for future integration. BMC SYST BIOL 2011;5 (1):165 [PubMed]
van Manen D, Delaneau O, Kootstra NA, Boeser-Nunnink BD, Limou S, Bol SM, Burger JA, Zwinderman AH, Moerland PD, van 't Slot R, Zagury JF, van 't Wout AB, Schuitemaker H, Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course. PLOS ONE 2011;6 (7):e22208 [PubMed]
Hertoghs KML, Moerland PD, van Stijn A, Remmerswaal EBM, Yong SL, van de Berg PJEJ, van Ham SM, Baas F, ten Berge IJM, van Lier RAW, Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J CLIN INVEST 2010;120 (11):4077-4090 [PubMed]
Tijsen AJ, Creemers EE, Moerland PD, de Windt LJ, van der Wal AC, Kok WE, Pinto YM, MiR423-5p As a Circulating Biomarker for Heart Failure. CIRC RES 2010;106 (6):1035-U63 [PubMed]
Tijsen AJ, Creemers EE, Moerland PD, Pinto YM, MicroRNAs As Circulating Biomarkers for Heart Failure: Questions About MiR-423-5p Response. CIRC RES 2010;106 (9):E9
van der Pouw Kraan TCTM, Schirmer SH, Fledderus JO, Moerland PD, Baggen JM, Leyen TA, van der Laan AM, Piek JJ, van Royen N, Horrevoets AJG, Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients. BMC GENOMICS 2010;11 (1):388 [PubMed]
Bijl N, Sokolović M, Vrins C, Langeveld M, Moerland PD, Ottenhoff R, van Roomen CPAA, Claessen N, Boot RG, Aten J, Groen AK, Aerts JMFG, van Eijk M, Modulation of Glycosphingolipid Metabolism Significantly Improves Hepatic Insulin Sensitivity and Reverses Hepatic Steatosis in Mice. HEPATOLOGY 2009;50 (5):1431-1441 [PubMed]
Schirmer SH, Fledderus JO, van der Laan AM, van der Pouw-Kraan TCTM, Moerland PD, Volger OL, Baggen JM, Böhm M, Piek JJ, Horrevoets AJG, van Royen N, Suppression of inflammatory signaling in monocytes from patients with coronary artery disease. J MOL CELL CARDIOL 2009;46 (2):177-185 [PubMed]
Schirmer SH, van Royen N, Moerland PD, Fledderus JO, Henriques JP, van der Schaaf RJ, Vis MM, Baan J Jr, Koch KT, Horrevoets AJG, Hoefer IE, Piek JJ, Local Cytokine Concentrations and Oxygen Pressure Are Related to Maturation of the Collateral Circulation in Humans. J AM COLL CARDIOL 2009;53 (23):2141-2147 [PubMed]
Sontrop HMJ, Moerland PD, van den Ham R, Reinders MJT, Verhaegh WFJ, A comprehensive sensitivity analysis of microarray breast cancer classification under feature variability. BMC BIOINFORMATICS 2009;10:389 [PubMed]
van Munster BC, van Breemen MJ, Moerland PD, Speijer D, de Rooij SE, Pfrommer CJ, Levi M, Hollmann MW, Aerts JM, Zwinderman AH, Korevaar JC, Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium. J NEUROPSYCH CLIN N 2009;21 (3):284-291 [PubMed]
Wegdam W, Moerland PD, Buist MR, Ver Loren van Themaat E, Bleijlevens B, Hoefsloot HCJ, de Koster CG, Aerts JMFG, Classification-based comparison of pre-processing methods for interpretation of mass spectrometry generated clinical datasets. PROTEOME SCI 2009;7 (1):19-(17 p) [PubMed]
Biewenga P, Buist MR, Moerland PD, van Thernaat EVL, van Kampen AHC, ten Kate FJW, Baas F, Gene expression in early stage cervical cancer. GYNECOL ONCOL 2008;108 (3):520-526 [PubMed]
Lagarde SM, Ver Loren van Themaat PE, Moerland PD, Gilhuijs-Pederson LA, ten Kate FJW, Reitsma PH, van Kampen AHC, Zwinderman AH, Baas F, van Lanschot JJB, Analysis of Gene Expression Identifies Differentially Expressed Genes and Pathways Associated with Lymphatic Dissemination in Patients with Adenocarcinoma of the Esophagus. ANN SURG ONCOL 2008;15 (12):3459-3470 [PubMed]
Schirmer SH, Fledderus JO, Bot PTG, Moerland PD, Hoefer IE, Baan J Jr, Henriques JPS, van der Schaaf RJ, Vis MM, Horrevoets AJG, Piek JJ, van Royen N, Interferon-beta signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice. CIRC RES 2008;102 (10):1286-1294 [PubMed]
van de Mortel JE, Schat H, Moerland PD, Ver Loren van Themaat E, van der Ent S, Blankestijn H, Ghandilyan A, Tsiatsiani S, Aarts MGM, Expression differences for genes involved in lignin, glutathione and sulphate metabolism in response to cadmium in Arabidopsis thaliana and the related Zn/Cd-hyperaccumulator Thlaspi caerulescens. PLANT CELL ENVIRON 2008;31 (3):301-324 [PubMed]
Zelinkova Z, van Beelen AJ, de Kort F, Moerland PD, van Themaat EVL, te Velde AA, van Deventer SJ, de Jong EC, Hommes DW, Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn's disease patient-derived dendritic cells. INFLAMM BOWEL DIS 2008;14 (2):186-194 [PubMed]
Soufan AT, van den Berg G, Moerland PD, Massink MMG, van den Hoff MJB, Moorman AFM, Ruijter JM, Three-dimensional measurement and visualization of morphogenesis applied to cardiac embryology. J MICROSC-OXFORD 2007;225 (Part 3):269-274 [PubMed]
Volger OL, Fledderus JO, Kisters N, Fontijn RD, Moerland PD, Kuiper J, van Berkel TJ, Bijnens APJJ, Daemen MJAP, Pannekoek H, Horrevoets AJG, Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. AM J PATHOL 2007;171 (1):326-337 [PubMed]
van de Mortel JE, Almar Villanueva L, Schat H, Kwekkeboom J, Coughlan S, Moerland PD, Ver Loren van Themaat E, Koornneef M, Aarts MGM, Large expression differences in genes for iron and zinc homeostasis, stress response, and lignin biosynthesis distinguish roots of Arabidopsis thaliana and the related metal hyperaccumulator Thlaspi caerulescens. PLANT PHYSIOL 2006;142 (3):1127-1147 [PubMed]
Moerland PD, Fiesler E, Saxena I, Incorporation of liquid-crystal light valve nonlinearities in optical multilayer neural networks. APPL OPTICS 1996;35 (26):5301-5307 [PubMed]
Thimm G, Moerland P, Fiesler E, The interchangeability of learning rate and gain in backpropagation neural networks. NEURAL COMPUT 1996;8 (2):451-460 [PubMed]
Key publications

Stobbe MD, Houten SM, van Kampen AHC, Wanders RJA, Moerland PD, Improving the description of metabolic networks: the TCA cycle as example. FASEB J 2012;26 (9):3625-3636 [PubMed]
Stobbe MD, Houten SM, Jansen GA, van Kampen AHC, Moerland PD, Critical assessment of human metabolic pathway databases: a stepping stone for future integration. BMC SYST BIOL 2011;5 (1):165 [PubMed]
Hertoghs KML, Moerland PD, van Stijn A, Remmerswaal EBM, Yong SL, van de Berg PJEJ, van Ham SM, Baas F, ten Berge IJM, van Lier RAW, Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J CLIN INVEST 2010;120 (11):4077-4090 [PubMed]
Boekel J, Chilton JM, Cooke IR, Horvatovich PL, Jagtap PD, Käll L, Lehtiö J, Lukasse P, Moerland PD, Griffin TJ, Multi-omic data analysis using Galaxy. NAT BIOTECHNOL 2015;33 (2):137-139 [PubMed]
Bergonzi S, Albani MC, Ver Loren van Themaat E, Nordström KJV, Wang R, Schneeberger K, Moerland PD, Coupland G, Mechanisms of Age-Dependent Response to Winter Temperature in Perennial Flowering of Arabis alpina. SCIENCE 2013;340 (6136):1094-1097 [PubMed]


All Publications

Research programmes

Prof. dr. A.H.C. van Kampen (Medical Bioinformatics and e-Bioscience)

Other research related activities
  • Contribution to training of professionals, Other
  • Membership of medical or scientific committee, ZonMw (Netherlands Organisation for Health Research and Development), More Knowledge with Fewer Animals
Current research funding
  • ZonMw