• Principal Investigator
  • Male

Dr. A.P.J Vlaar MD PhD

Position: Other
Main activities: Patient care, Research, Teaching
Specialisation: Internal Medicine, Intensive Care Medicine
foto A.P.J Vlaar is one of the AMC Principal Investigators
Focus of research:

Transfusion related morbidity and mortality in the critically ill

AMC themes: Cardiovascular Diseases, Infection & Immunity
Departments: Intensive Care Medicine
Bosboom JJ, Klanderman RB, Peters AL, van de Weerdt EK, Goudswaard EJ, Binnekade JM, Zwaginga JJ, Beckers EAM, Geerts BF, Hollmann MW, Zeerleder SS, van Kraaij M, Vlaar AP, The practice of diagnosing and reporting transfusion-associated circulatory overload: a national survey among physicians and haemovigilance officers. TRANSFUSION MED 2017;ahead of print [PubMed]
Cortjens B, Ingelse SA, Calis JC, Vlaar AP, Koenderman L, Bem RA, van Woensel JB, Neutrophil subset responses in infants with severe viral respiratory infection. CLIN IMMUNOL 2017;176:100-106 [PubMed]
Garraud O, Tissot JD, Vlaar AP, Short-Term versus Long-Term Blood Storage. NEW ENGL J MED 2017;376 (11):1091 [PubMed]
Juffermans NP, Vlaar AP, Possible TRALI is a real entity. TRANSFUSION 2017;57 (10):2539-2541 [PubMed]
Morsing KSH, Peters AL, van Buul J, Vlaar APJ, The role of endothelium in the onset of antibody-mediated TRALI. BLOOD REV 2017;ahead of print [PubMed]
Peters AL. Blood transfusion: Transfusion-related acute lung injury: back to basics. S.l.: s.n.; 2017. 282p. ISBN 978-94-028-0539-0 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Juffermans NP; copromotor(s): Vlaar APJ)
Peters AL, Gerritsen MG, Brinkman P, Zwinderman KAH, Vlaar APJ, Bos LD, Volatile organic compounds in exhaled breath are independent of systemic inflammatory syndrome caused by intravenous lipopolysaccharide infusion in humans: results from an experiment in healthy volunteers. J BREATH RES 2017;11 (2):026003 [PubMed]
Peters AL, Kunanayagam RK, van Bruggen R, de Korte D, Juffermans NP, Vlaar APJ, Transfusion of 35-day stored red blood cells does not result in increase of plasma non-transferrin bound iron in human endotoxemia. TRANSFUSION 2017;57 (1):53-59 [PubMed]
Peters AL, van Hezel ME, Klanderman RB, Tuip-de Boer AM, Wiersinga WJ, van der Spek AH, van Bruggen R, de Korte D, Juffermans NP, Vlaar APJ, Transfusion of 35-day-stored red blood cells does not alter lipopolysaccharide tolerance during human endotoxemia. TRANSFUSION 2017;57 (6):1359-1368 [PubMed]
Peters AL, Veldthuis M, van Leeuwen K, Bossuyt PMM, Vlaar APJ, van Bruggen R, de Korte D, van Noorden CJF, van Zwieten R, Comparison of Spectrophotometry, Chromate Inhibition, and Cytofluorometry Versus Gene Sequencing for Detection of Heterozygously Glucose-6-Phosphate Dehydrogenase-Deficient Females. J HISTOCHEM CYTOCHEM 2017;65 (11):627-636 [PubMed]
Peters AL, Vervaart MAT, van Bruggen R, de Korte D, Nieuwland R, Kulik W, Vlaar APJ, Non-polar lipids accumulate during storage of transfusion products and do not contribute to the onset of transfusion-related acute lung injury. VOX SANG 2017;112 (1):25-32 [PubMed]
Schmidt RL, Mock DM, Franco RS, Cohen RM, North AK, Cancelas JA, Geisen C, Strauss RG, Vlaar AP, Nalbant D, Widness JA, Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose. TRANSFUSION 2017;57 (6):1488-1496 [PubMed]
Smeets MWJ, Bierings R, Meems H, Mul FPJ, Geerts D, Vlaar APJ, Voorberg J, Hordijk PL, Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor. PLOS ONE 2017;12 (3):e0173077 [PubMed]
van der Sluijs AF, van Slobbe-Bijlsma ER, Chick SE, Vroom MB, Dongelmans DA, Vlaar APJ, The impact of changes in intensive care organization on patient outcome and cost-effectiveness-a narrative review. J INTENSIVE CARE 2017;5:13 [PubMed]
van de Weerdt EK, Biemond BJ, Baake B, Vermin B, Binnekade JM, van Lienden KP, Vlaar APJ, Central venous catheter placement in coagulopathic patients: risk factors and incidence of bleeding complications. TRANSFUSION 2017;57 (10):2512-2525 [PubMed]
van de Weerdt EK, Peters AL, Goudswaard EJ, Binnekade JM, van Lienden KP, Biemond BJ, Vlaar APJ, The practice of platelet transfusion prior to central venous catheterization in presence of coagulopathy: a national survey among clinicians. VOX SANG 2017;112 (4):343-351 [PubMed]
Borgert M, Binnekade J, Paulus F, Vroom M, Vlaar A, Goossens A, Dongelmans D, Implementation of a transfusion bundle reduces inappropriate red blood cell transfusions in intensive care - a before and after study. TRANSFUSION MED 2016;26 (6):432-439 [PubMed]
Peters AL, Beuger B, Mock DM, Widness JA, de Korte D, Juffermans NP, Vlaar APJ, van Bruggen R, Clearance of stored red blood cells is not increased compared with fresh red blood cells in a human endotoxemia model. TRANSFUSION 2016;56 (6):1362-1369 [PubMed]
Peters AL, van Bruggen R, de Korte D, van Noorden CJF, Vlaar APJ, Glucose-6-phosphate dehydrogenase activity decreases during storage of leukoreduced red blood cells. TRANSFUSION 2016;56 (2):427-432 [PubMed]
Peters AL, van Hezel ME, Cortjens B, Tuip-de Boer AM, van Bruggen R, de Korte D, Jonkers RE, Bonta PI, Zeerleder SS, Lutter R, Juffermans NP, Vlaar APJ, Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans. CRIT CARE MED 2016;44 (6):e412-e419 [PubMed]
Peters AL, Vlaar APJ, Redefining transfusion-related acute lung injury: don't throw the baby out with the bathwater. TRANSFUSION 2016;56 (9):2384-2388 [PubMed]
van Stein D, Beckers EAM, Peters AL, Porcelijn L, Middelburg RA, Lardy NM, van Rhenen DJ, Vlaar APJ, Underdiagnosing of antibody-mediated transfusion-related acute lung injury: evaluation of cellular-based versus bead-based techniques. VOX SANG 2016;111 (1):71-78 [PubMed]
Vlaar APJ, HECTD2 one step closer to understand susceptibility for acute respiratory disease syndrome?. ANN TRANSL MED 2016;4 (24):528 [PubMed]
Mathijssen-van Stein D. Transfusion-Related Acute Lung Injury - The role of donor antibodies. S.l.: s.n.; 2015. 143p. ISBN 978-94-6169-713-4 Proefschrift Erasmus Universiteit Rotterdam, -. (Promotor(s): van Rhenen DJ; copromotor(s): Beckers EAM, Vlaar APJ)
Müller MCA , van Stein D, Binnekade JM, van Rhenen DJ, Vlaar APJ, Low-risk transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a meta-analysis. TRANSFUSION 2015;55 (1):164-175 [PubMed]
Peters AL, van Hezel ME, Juffermans NP, Vlaar APJ, Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside. BLOOD REV 2015;29 (1):51-61 [PubMed]
Peters AL, van Stein D, Vlaar APJ, Antibody-mediated transfusion-related acute lung injury; from discovery to prevention. BRIT J HAEMATOL 2015;170 (5):597-614 [PubMed]
Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NLC, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S [Contributors: Luban NLC, Roubinian NH, Hendrickson J, Zimring JC, Yazdanbakhsh K, Delaney M, Ware RE, Tinmouth A, Doctor A, Migliaccio AR, Fergusson DA, Widness JA, Carson JL, Hess J, Roback JD, Waters JH, Cancelas JA, Gladwin MT, Rogers MAM, Ness PM, Rao S, Watkins TR, Gernsheimer T, Josephson CD, Spinella PC, Kaufman RM, Slichter SJ, McCullough J, Blumberg N, Webert KE, Fitzpatrick M, Shander A, Corash LM, Murphy M, Silberstein LE, Dumont LJ, Mitchell WB, Macdonald VW, Hoffmeister KM, Italiano JE, Gupta AS, Wu Y, Cap AP, Li R, Goodrich RP, Morrell CN, Semple JW, Kahr WHA, Mondoro T, Dzik WH, Kor DJ, Tanaka K, Haas T, Sperry JL, Callum JL, Porte RJ, Mallett S, Gajic O, Juffermans NP, Karam O, Vlaar APJ, Looney MR, Inaba K, Shaz BH, Hunt BJ, Cohen MJ, Kitchens CS, Stanworth SJ, Devine DV, Eder AF, Bryant BJ, Kiss JE, Busch MP, Dodd RY, Heddle NM, Spencer BR, Keller AJ, Germain M, Goldman M, Tomasulo PA, de Kort W, Mast AE, Francis RO]] , 2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium. TRANSFUSION 2015;55 (9):2282-2290 [PubMed]
Vlaar APJ, Juffermans NP. Transfusion-Related Acute Lung Injury in: Juffermans NP, Walsh TS, editors. Transfusion in the Intensive Care Unit. New York: Springer; 2015., p. 161-169
Cornet AD, Groeneveld ABJ, Hofstra JJ, Vlaar AP, Tuinman PR, van Lingen A, Levi M, Girbes ARJ, Schultz MJ, Beishuizen A, Recombinant human activated protein C in the treatment of acute respiratory distress syndrome: a randomized clinical trial. PLOS ONE 2014;9 (3):e90983 [PubMed]
Müller MCA , Tuinman PR, Vlaar AP, Tuip AM, Maijoor K, Achouiti A, van T Veer C, Vroom MB, Juffermans NP, Contribution of damage-associated molecular patterns to transfusion-related acute lung injury in cardiac surgery. BLOOD TRANSFUS-ITALY 2014;12 (3):368-375 [PubMed]
Cornet AD, Hofstra JJ, Vlaar AP, Tuinman PR, Levi M, Girbes AR, Schultz MJ, Groeneveld AB, Beishuizen A, Activated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome. J THROMB HAEMOST 2013;11 (5):894-901 [PubMed]
Hofstra JJ, Cornet AD, Declerck PJ, Dixon B, Aslami H, Vlaar APJ, Roelofs JJ, van der Poll T, Levi M, Schultz MJ, Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury. PLOS ONE 2013;8 (2):e55262 [PubMed]
Kuipers MT, Vogl T, Aslami H, Jongsma G, van den Berg E, Vlaar APJ, Roelofs JJTH, Juffermans NP, Schultz MJ, van der Poll T, Roth J, Wieland CW, High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling. PLOS ONE 2013;8 (7):e68694 [PubMed]
Tuinman PR, Cornet AD, Kuipers MT, Vlaar AP, Schultz MJ, Beishuizen A, Groeneveld ABJ, Juffermans NP, Soluble receptor for advanced glycation end products as an indicator of pulmonary vascular injury after cardiac surgery. BMC PULM MED 2013;13 (1):76 [PubMed]
Vlaar APJ, Hovius JWR, Stijnis K, van Vugt M, Pareses, paralysis and parasites. Echinococcus granulosus infection. NETH J MED 2013;71 (10):529, 533-+ [PubMed]
Vlaar APJ, Juffermans NP, Transfusiegerelateerde acute longschade. NED TIJDSCHR GENEESKD 2013;157 (11):A5524 [PubMed]
Vlaar APJ, Juffermans NP, Transfusion-related acute lung injury: a clinical review. LANCET 2013;382 (9896):984-994 [PubMed]
Hofstra JJ, Vlaar APJ, Prins DJ, Koh G, Levi M, Schultz MJ, Binnekade JM, Juffermans NP, Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome - a retrospective propensity matched cohort study. BMC PULM MED 2012;12 (1):43 [PubMed]
Hofstra JJ, Vlaar AP, Knape P, Mackie D, Schultz MJ, Re: Coagulopathy after burn and smoke inhalation injury Reply. J TRAUMA ACUTE CARE 2012;72 (4):1122-1123 [PubMed]
Juffermans NP, Vlaar APJ, Prins DJ, Goslings JC, Binnekade JM, The age of red blood cells is associated with bacterial infections in critically ill trauma patients. BLOOD TRANSFUS-ITALY 2012;10 (3):290-295 [PubMed]
Koh GCKW, Vlaar APJ, Hofstra JJ, de Jong HK, van Nierop S, Peacock SJ, Wiersinga WJ, Schultz MJ, Juffermans NP, In the critically ill patient, diabetes predicts mortality independent of statin therapy but is not associated with acute lung injury: A cohort study. CRIT CARE MED 2012;40 (6):1835-1843 [PubMed]
Kuipers MT, Aslami H, Janczy JR, van der Sluijs KF, Vlaar APJ, Wolthuis EK, Choi G, Roelofs JJTH, Flavell RA, Sutterwala FS, Bresser P, Leemans JC, van der Poll T, Schultz MJ, Wieland CW, Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome. ANESTHESIOLOGY 2012;116 (5):1104-1115 [PubMed]
Kuipers MT, Aslami H, Vlaar APJ, Juffermans NP, Tuip-de Boer AM, Hegeman MA, Jongsma G, Roelofs JJTH, van der Poll T, Schultz MJ, Wieland CW, Pre-Treatment with Allopurinol or Uricase Attenuates Barrier Dysfunction but Not Inflammation during Murine Ventilator-Induced Lung Injury. PLOS ONE 2012;7 (11):e50559 [PubMed]
Müller MCA , Porcelijn L, Vlaar APJ, Prevention of Immune-mediated Transfusion-related Acute Lung Injury; from Bloodbank to Patient. CURR PHARM DESIGN 2012;18 (22):3241-3248 [PubMed]
Tuinman PR, Vlaar AP, Binnenkade JM, Juffermans NP, The effect of aspirin in transfusion-related acute lung injury in critically ill patients. ANAESTHESIA 2012;67 (6):594-599 [PubMed]
Veelo DP, Vlaar AP, Dongelmans DA, Binnekade JM, Levi M, Paulus F, Berends F , Schultz MJ, Correction of subclinical coagulation disorders before percutaneous dilatational tracheotomy. A randomised controlled trial. BLOOD TRANSFUS-ITALY 2012;10 (2):213-220 [PubMed]
Vlaar A, Preventive and Therapeutic Strategies for Transfusion-Related Acute Lung Injury. CURR PHARM DESIGN 2012;18 (22):3235 [PubMed]
Vlaar APJ, Transfusion-related acute lung injury: Current understanding and preventive strategies. TRANSFUS CLIN BIOL 2012;19 (3):117-124 [PubMed]
Vlaar APJ, Cornet AD, Hofstra JJ, Porcelijn L, Beishuizen A, Kulik W, Vroom MB, Schultz MJ, Groeneveld ABJ, Juffermans NP, The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study. TRANSFUSION 2012;52 (1):82-90 [PubMed]
Vlaar APJ, Hofstra JJ, Determann RM, Veelo DP, Paulus F, Levi M, Zeerleder S, Vroom MB, Schultz MJ, Juffermans NP, Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: A prospective nested case-control study. CRIT CARE MED 2012;40 (10):2813-2820 [PubMed]
Vlaar APJ, Juffermans NP, de Korte D, Bioactive lipids from stored cellular blood components: in vitro method is crucial for proper interpretation In reply. TRANSFUSION 2012;52 (5):1157-1158 [PubMed]
Vlaar APJ, Kuipers MT, Hofstra JJ, Wolthuis EK, Wieland CW, Roelofs JJTH, Boon L, Schultz MJ, Lutter R, Juffermans NP, Mechanical ventilation and the titer of antibodies as risk factors for the development of transfusion-related lung injury. CRIT CARE RES PRACT 2012;2012:720950 [PubMed]
Wolthuis EK, Vlaar APJ, Choi G, Roelofs JJTH, Levi M, Juffermans NP, Schultz MJ, Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. CRIT CARE RES PRACT 2012;2012:130410 [PubMed]
Backes Y, van der Sluijs KF, Tuip de Boer AM, Hofstra JJ, Vlaar APJ, Determann RM, Knape P, Mackie DP, Schultz MJ, Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation: an observational cohort study. CRIT CARE 2011;15 (6):R270 [PubMed]
Cornet AD, Hofstra JJ, Vlaar AP, van den Boogaard FE, Roelofs JJ, van der Poll T, Levi M, Groeneveld ABJ, Schultz MJ, Nebulized anticoagulants limit coagulopathy but not inflammation in pseudomonas aeruginosa-induced pneumonia in rats. SHOCK 2011;36 (4):417-423 [PubMed]
Hofstra JJ, Vlaar AP, Knape P, Mackie DP, Determann RM, Choi G, van der Poll T, Levi M, Schultz MJ, Pulmonary activation of coagulation and inhibition of fibrinolysis after burn injuries and inhalation trauma. J TRAUMA 2011;70 (6):1389-1397 [PubMed]
Juffermans NP, Prins DJ, Vlaar APJ, Nieuwland R, Binnekade JM, TRANSFUSION-RELATED RISK OF SECONDARY BACTERIAL INFECTIONS IN SEPSIS PATIENTS: A RETROSPECTIVE COHORT STUDY. SHOCK 2011;35 (4):355-359 [PubMed]
Lede I, Vlaar A, Roosendaal R, Geerlings S, Spanjaard L, Fatal outcome of Bacillus cereus septicaemia. NETH J MED 2011;69 (11):514-516 [PubMed]
Postema PG, Vlaar APJ, DeVries JH, Tan HL, Familial Brugada syndrome uncovered by hyperkalaemic diabetic ketoacidosis. EUROPACE 2011;13 (10):1509-1510 [PubMed]
Tuinman PR, Gerards MC, Jongsma G, Vlaar AP, Boon L, Juffermans NP, Lack of evidence of CD40 ligand involvement in transfusion-related acute lung injury. CLIN EXP IMMUNOL 2011;165 (2):278-284 [PubMed]
Tuinman PR, Vlaar AP, Cornet AD, Hofstra JJ, Levi M, Meijers JCM, Beishuizen A, Schultz MJ, Groeneveld AJ, Juffermans NP, Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study. CRIT CARE 2011;15 (1):R59 [PubMed]
Vlaar APJ, Binnekade JM, Juffermans NP, The authors reply: Risk factors for transfusion-related acute lung injury: Improper analysis of matched data. CRIT CARE MED 2011;39 (3):611 [PubMed]
Vlaar APJ, Hofstra JJ, Determann RM, Veelo DP, Paulus F, Kulik W, Korevaar J, de Mol BA, Koopman MMW, Porcelijn L, Binnekade JM, Vroom MB, Schultz MJ, Juffermans NP, The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. BLOOD 2011;117 (16):4218-4225 [PubMed]
Vlaar APJ, Kulik W, Nieuwland R, Peters CP, Tool ATJ, van Bruggen R, Juffermans NP, de Korte D, Accumulation of bioactive lipids during storage of blood products is not cell but plasma derived and temperature dependent. TRANSFUSION 2011;51 (11):2358-2366 [PubMed]
Vlaar APJ, Kunst PWA, Tropical fever. NETH J MED 2011;69 (4):198, 200-+ [PubMed]
Vlaar APJ, Rietdijk ST, Zeerleder SS, Boerman T, Beuers U, Malignancies associated with chronic hepatitis C: case report and review of the literature. NETH J MED 2011;69 (5):211-215 [PubMed]
Vlaar AP, Straat M, Juffermans NP, The relation between aged blood products and onset of transfusion-related acute lung injury. A review of pre-clinical data. CLIN LAB 2011;57 (3-4):267-272 [PubMed]
Wolthuis EK, Vlaar APJ, Hofstra JJH, Roelofs JJTH, de Waard V, Juffermans NP, Schultz MJ, Plasminogen activator inhibitor-type I gene deficient mice show reduced influx of neutrophils in ventilator-induced lung injury. CRIT CARE RES PRACT 2011;2011:217896 [PubMed]
Berger MM, Pitzer B, Zügel S, Wieland CW, Vlaar AP, Schultz MJ, Dahan A, Bärtsch P, Hollmann MW, Mairbäurl H, Alveolar but not intravenous S-ketamine inhibits alveolar sodium transport and lung fluid clearance in rats. ANESTH ANALG 2010;111 (1):164-170 [PubMed]
Determann RM, Royakkers A, Wolthuis EK, Vlaar AP, Choi G, Paulus F, Hofstra JJ, de Graaff MJ, Korevaar JC, Schultz MJ, Ventilation with lower tidal volumes as compared to conventional tidal volumes for patients without acute lung injury - a preventive randomized controlled trial. CRIT CARE 2010;14 (1):R1 [PubMed]
Hofstra JJ, Vlaar AP, Cornet AD, Dixon B, Roelofs JJ, Choi G, van der Poll T, Levi M, Schultz MJ, Nebulized Anticoagulants Limit Pulmonary Coagulopathy, But Not Inflammation, in a Model of Experimental Lung Injury. J AEROSOL MED PULM D 2010;23 (2):105-111 [PubMed]
Vlaar APJ. Transfusion-related acute lung injury in the critically ill. A translational approach. s.l.: s.n.; 2010. 371p. ISBN 97890902565504 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Vroom MB, Schultz MJ; copromotor(s): Juffermans NP)
Vlaar APJ, Binnekade JM, Prins D, van Stein D, Hofstra JJ, Schultz MJ, Juffermans NP, Risk factors and outcome of transfusion-related acute lung injury in the critically ill: A nested case-control study. CRIT CARE MED 2010;38 (3):771-778 [PubMed]
Vlaar APJ, Hofstra JJ, Kulik W, van Lenthe H, Nieuwland R, Schultz MJ, Levi MM, Roelofs JJTH, Tool ATJ, de Korte D, Juffermans NP, Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model. BLOOD 2010;116 (8):1360-1368 [PubMed]
Vlaar APJ, Hofstra JJ, Levi M, Kulik W, Nieuwland R, Tool ATJ, Schultz MJ, de Korte D, Juffermans NP, Supernatant of Aged Erythrocytes Causes Lung Inflammation and Coagulopathy in a "Two-Hit" In Vivo Syngeneic Transfusion Model. ANESTHESIOLOGY 2010;113 (1):92-103 [PubMed]
Vlaar APJ, Porcelijn L, van Rooijen-Schreurs IHM, Lardy NM, Kersten MJ, Juffermans NP, The divergent clinical presentations of transfusion-related acute lung injury illustrated by two case reports. MED SCI MONITOR 2010;16 (10):CS129-CS134 [PubMed]
Vlaar APJ, Wolthuis EK, Hofstra JJ, Roelofs JJTH, Boon L, Schultz MJ, Lutter R, Juffermans NP, Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC-I class antibodies. INTENS CARE MED 2010;36 (5):879-887 [PubMed]
Vlaar AP, Wortel K, Binnekade JM, van Oers MHJ, Beckers E, Gajic O, Schultz MJ, Juffermans NP, The practice of reporting transfusion-related acute lung injury: a national survey among clinical and preclinical disciplines. TRANSFUSION 2010;50 (2):443-451 [PubMed]
Hofstra JJ, Cornet AD, de Rooy BF, Vlaar AP, van der Poll T, Levi M, Zaat SAJ, Schultz MJ, Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats. CRIT CARE 2009;13 (5):R145 [PubMed]
Vlaar APJ, de Korte D, Juffermans NP, The Aged Erythrocyte: Key Player in Cancer Progression, but Also in Infectious and Respiratory Complications of Blood Transfusion?. ANESTHESIOLOGY 2009;111 (2):444 [PubMed]
Vlaar APJ, Honselaar WB, Binnekade JM, Groeneveld AB, Spronk PE, Schultz MJ, Juffermans NP, Diagnosing acute lung injury in the critically ill: a national survey among critical care physicians. ACTA ANAESTH SCAND 2009;53 (10):1293-1299 [PubMed]
Vlaar APJ, in der Maur AL, Binnekade JM, Schultz MJ, Juffermans NP, A survey of physicians' reasons to transfuse plasma and platelets in the critically ill: a prospective single-centre cohort study. TRANSFUSION MED 2009;19 (4):207-212 [PubMed]
Vlaar APJ, In der Maur AL, Binnekade JM, Schultz MJ, Juffermans NP, Determinants of transfusion decisions in a mixed Medical-Surgical Intensive Care Unit: a prospective cohort study. BLOOD TRANSFUS-ITALY 2009;7 (2):106-110 [PubMed]
Vlaar APJ, van Son WJ, Bakker WW, Histochemical Detection of Ischemia-Like Alterations Induced in Kidney Tissue in vitro - Different Sensitivity to Oxidant Stress of Glomerular ENTPD1 versus E5NT. NEPHRON PHYSIOL 2009;111 (1):P1-P8 [PubMed]
Vlaar AP, Schultz MJ, Juffermans NP, Transfusion-related acute lung injury: a change of perspective. NETH J MED 2009;67 (10):320-326 [PubMed]
Wolthuis EK, Vlaar AP, Choi G, Roelofs JJTH, Juffermans NP, Schultz MJ, Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice. CRIT CARE 2009;13 (1):R1 [PubMed]
Wolthuis EK, Vlaar APJ, Choi G, Roelofs JJTH, Haitsma JJ, van der Poll T, Juffermans NP, Zweers MM, Schultz MJ, Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury. SHOCK 2009;31 (3):262-266 [PubMed]
Vlaar APJ, Binnekade JM, Schultz MJ, Juffermans NP, Koopman MMW, Preventing TRALI: Ladies first, what follows?. CRIT CARE MED 2008;36 (12):3283-3284 [PubMed]
Vlaar APJ, Schultz MJ, Juffermans NP, Transfusiegerelateerde acute longbeschadiging (TRALI) in Nederland in 2002-2005. NED TIJDSCHR GENEESKD 2008;152 (35):1945-1946 [PubMed]
Wiersum-Osselton JC, Porcelijn L, van Stein D, Vlaar APJ, Beckers EAM, Schipperus MR, Transfusiegerelateerde acute longbeschadiging (TRALI) in Nederland in 2002-2005. NED TIJDSCHR GENEESKD 2008;152 (32):1784-1788 [PubMed]
Choi G, Vlaar APJ, Schouten M, van't Veer C, van der Poll T, Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation. EUR RESPIR J 2007;30 (3):423-428 [PubMed]
Vlaar APJ, ten Klooster PM, Taal E, Gheith RE, El-Garf AK, Rasker JJ, van de Laar MAFJ, A cross-cultural study of pain intensity in Egyptian and dutch women with rheumatoid arthritis. J PAIN 2007;8 (9):730-736 [PubMed]
Vlaar APJ, van Soest EJ, Levi M, van Lienden KP, Boermeester M, de Jonge E, Een patiënt met recidiverende levensbedreigende darmbloedingen behandeld met medicamenteuze, chirurgische, endoscopische, interventieradiologische en conservatieve methoden. NED TIJDSCHR GENEESKD 2007;151 (25):1412-1417 [PubMed]
Vlaar APJ, Zweers MM, Schultz MJ, Juffermans NP, Developing specific therapeutic strategies for transfusion-related acute lung injury. An overview of potentially useful animal models. CARDIOVASC HEMATOL AGENTS MED CHEM 2007;5 (4):319-326 [PubMed]
ten Klooster PM, Vlaar APJ, Taal E, Gheith RE, Rasker JJ, El-Garf AK, van de Laar MAFJ, The validity and reliability of the graphic rating scale and verbal rating scale for measuring pain across cultures: A study in Egyptian and Dutch women with rheumatoid arthritis. CLIN J PAIN 2006;22 (9):827-830 [PubMed]
Key publications

Vlaar APJ, Juffermans NP, Transfusion-related acute lung injury: a clinical review. LANCET 2013;382 (9896):984-994 [PubMed]
Vlaar APJ, Hofstra JJ, Determann RM, Veelo DP, Paulus F, Kulik W, Korevaar J, de Mol BA, Koopman MMW, Porcelijn L, Binnekade JM, Vroom MB, Schultz MJ, Juffermans NP, The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. BLOOD 2011;117 (16):4218-4225 [PubMed]
Vlaar APJ, Hofstra JJ, Kulik W, van Lenthe H, Nieuwland R, Schultz MJ, Levi MM, Roelofs JJTH, Tool ATJ, de Korte D, Juffermans NP, Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model. BLOOD 2010;116 (8):1360-1368 [PubMed]
Peters AL, van Hezel ME, Cortjens B, Tuip-de Boer AM, van Bruggen R, de Korte D, Jonkers RE, Bonta PI, Zeerleder SS, Lutter R, Juffermans NP, Vlaar APJ, Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans. CRIT CARE MED 2016;44 (6):e412-e419 [PubMed]
Müller MCA , van Stein D, Binnekade JM, van Rhenen DJ, Vlaar APJ, Low-risk transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a meta-analysis. TRANSFUSION 2015;55 (1):164-175 [PubMed]


All Publications

Research programmes

Transfusion related morbidity and mortality

Alexander Vlaar has received his MD degree in 2005 from the Faculty of Medicine of the University of Groningen and his PhD degree in 2010 from the Faculty of Medicine of the University of Amsterdam. In 2015 he was board certified in Internal Medicine and in 2016 he received European board certification in Intensive Care Medicine. Since 2016, Alexander Vlaar is consultant critical care medicine and principal investigator at the Department of Intensive Care Medicine and at the Laboratory of Experimental Intensive Care and Anesthesiology. 

Focus of Alexanders’ research is transfusion related morbidity and mortality in the critically ill. His research lines consist, among others, of pre-clinical and clinical investigation in the field of antibody and non-antibody mediated transfusion related acute lung injury (TRALI). Alexander Vlaar is currently supported by a personal grant from the Netherlands Organization for Health Research and Development (NWO-VENI grant 2013). His research has been awarded with many scientific awards. Recently he received for his work the Heineken Young Scientist Award for Medicine 2014 from the Royal Netherlands Academy of Arts and Sciences (KNAW).

Faculty
Dr. A.P.J Vlaar MD PhD
Prof. dr. M.W. Hollmann MD PhD
Prof. N.P. Juffermans MD PhD
Prof. W.S. Schlack MD PhD
Prof. M.J. Schultz MD PhD
Prof. dr. M.B. Vroom MD
Prof. dr. W.J. Wiersinga MD PhD

PhD Students
Drs. J. Bosboom
S. de Bruin MSc (Sanquin)
R.B. Klanderman MD
K.S.H. Morsing (Sanquin Research and Landsteiner Laboratory)
Drs. E.K. van de Weerdt
M. Wijnberge

Prof. dr. M.W. Hollmann MD PhD (Organprotection)

Prof. M.J. Schultz MD PhD (Prevention and treatment of organ failure in intensive care medicine)

Prof. N.P. Juffermans MD PhD (Pathogenesis and treatment of organ failure in the critically ill)

Other research related activities
  • None reported
Current research funding
  • NFU-consortium Kwaliteit van Zorg
  • Sanquin Plasma Products B.V.
  • Sanquin - Unit Transfusiegeneeskunde
  • ZonMw