• Principal Investigator
  • Male

Prof. dr. T.B.H. Geijtenbeek

Position: Professor
Main activities: Research, Teaching
Specialisation: Molecular and Cellular Immunology
foto T.B.H. Geijtenbeek is one of the AMC Principal Investigators
Focus of research:

My research focuses on the function of C-type lectins on dendritic cell subsets in adaptive immunity and infection in humans. C-type lectins interact with carbohydrate structures expressed by pathogens and it is becoming clear that C-type lectins alone or due to crosstalk with Toll-like receptors induce signaling pathways that are crucial in the induction of innate and adaptive immunity. We are studying the role of C-type lectins such as DC-SIGN, Langerin and dectin-1 in infections with viruses (HIV-1, measles virus), mycobacteria and fungi. It is becoming clear that some pathogens such as HIV-1 subvert the function and signaling of DC-SIGN for its survival and infection of the host. Furthermore, we are investigating the function of these pattern recognition receptors in the induction of aberrant adaptive immunity in diseases such as allergy and asthma.

AMC themes: Infection & Immunity
Departments: Experimental Immunology, Infectious Diseases: Infectious diseases
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Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F, Forrest ARR, Carninci P, Rehli M, Sandelin A, de Hoon MJL, Haberle V, Kulakovskiy IV, Lizio M, Schmeier S, Dimont E, Schmid C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple CA, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JAC, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Califano A, Cannistraci CV, Carbajo D, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge ASB, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furuno M, Furusawa Ji, Geijtenbeek TB, Gibson AP, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JFJ, Lee W, Lipovich L, Mackay-sim A, Manabe Ri, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, de Lima Morais DA, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Nozaki T, Ogishima S, Ohkura N, Ohmiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JGD, Rackham OJL, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Satoh H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Suzuki N, Swoboda RK, 't Hoen PAC, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyoda H, Toyoda T, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zucchelli S, Summers KM, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, An atlas of active enhancers across human cell types and tissues. NATURE 2014;507 (7493):455-461 [PubMed]
Cobos Jiménez V. HIV-1 infection in macrophages and genes involved throughout: big eaters versus small invaders. s.l.: s.n.; 2014. 171p. ISBN 9789461824127 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Geijtenbeek TBH; copromotor(s): Kootstra NA)
Hähnlein J, Ramwadhdoebe TH, Semmelink JF, Maijer KI , Choi IY, Smits NAM, Berger FH, Maas M, Gerlag DM, Geijtenbeek TB, Tak PP, van Baarsen LGM, A8.17 Expression of the autoimmune regulator aire in human lymph node stromal cells. ANN RHEUM DIS 2014;73 (Suppl. 1):A82-A83 [PubMed]
Mason LMK, Veerman CC, Geijtenbeek TBH, Hovius JWR, Menage a trois: Borrelia, dendritic cells, and tick saliva interactions. TRENDS PARASITOL 2014;30 (2):95-103 [PubMed]
Mesman AW. Host-pathogen interplay in viral transmission and immune evasion. s.l.: s.n.; 2014. 163p. ISBN 9789461824165 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Geijtenbeek TBH; copromotor(s): Gringhuis SI)
Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest ARR, Standley DM, Date H, Sakaguchi S [Contributors: Forrest ARR, Kawaji H, Rehli M, Baillie JK, de Hoon MJL, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple CA, Ishizu Y, Francescatto M, Alam I, Albanese D, Altschuler GM, Archer JAC, Arner P, Babina M, Baker S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Deplancke B, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge ASB, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furuno M, Furusawa Ji, Geijtenbeek TB, Gibson A, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Kondo N, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JFJ, Lee W, Lennartsson A, Li K, Lilje B, Lipovich L, Mackay-sim A, Manabe Ri, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, Morais DAdL, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Nozaki T, Ogishima S, Ohkura N, Ohmiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JGD, Rackham OJL, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Satoh H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Swoboda RK, 't Hoen PAC, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyoda H, Toyoda T, Valen E, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zhao X, Zucchelli S, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Sandelin A, Hume DA, Carninci P, Hayashizaki Y]] , Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation. P NATL ACAD SCI USA 2014;111 (14):5289-5294 [PubMed]
van den Berg LM, Zijlstra-Willems EM, Richters CD, Ulrich MMW, Geijtenbeek TBH, Dectin-1 activation induces proliferation and migration of human keratinocytes enhancing wound re-epithelialization. CELL IMMUNOL 2014;289 (1-2):49-54 [PubMed]
Wevers BA. C-type lectin signaling in dendritic cells. Molecular control of antifungal inflammation. s.l.: s.n.; 2014. -p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Geijtenbeek TBH; copromotor(s): Gringhuis SI)
Wevers BA, Kaptein TM, Zijlstra-Willems EM, Theelen B, Boekhout T, Geijtenbeek TBH, Gringhuis SI, Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. CELL HOST MICROBE 2014;15 (4):494-505 [PubMed]
[Contributors: Forrest ARR, Kawaji H, Rehli M, Baillie JK, de Hoon MJL, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple CA, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JAC, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge ASB, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furuno M, Furusawa Ji, Geijtenbeek TB, Gibson AP, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Kondo N, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JFJ, Lee W, Lennartsson A, Li K, Lilje B, Lipovich L, Mackay-sim A, Manabe Ri, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, de Lima Morais DA, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Nozaki T, Ogishima S, Ohkura N, Ohmiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JGD, Rackham OJL, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Satoh H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Suzuki N, Swoboda RK, 't Hoen PAC, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyoda H, Toyoda T, Valen E, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zhao X, Zucchelli S, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Sandelin A, Hume DA, Carninci P, Hayashizaki Y]] , A promoter-level mammalian expression atlas. NATURE 2014;507 (7493):462-470 [PubMed]
Brunen D, Mesman AW, Geijtenbeek TBH, RIG-I-like receptors and intracellular Toll-like receptors in antiviral immunity. FUTURE VIROL 2013;8 (2):183-194
Garcia-Vallejo JJ, Koning N, Ambrosini M, Kalay H, Vuist I, Sarrami-Forooshani R, Geijtenbeek TBH, van Kooyk Y, Glycodendrimers prevent HIV transmission via DC-SIGN on dendritic cells. INT IMMUNOL 2013;25 (4):221-233 [PubMed]
Geijtenbeek TBH, Gringhuis SI, An inside job for antibodies: tagging pathogens for intracellular sensing. NAT IMMUNOL 2013;14 (4):309-311 [PubMed]
Mayumi N, Watanabe E, Norose Y, Watari E, Kawana S, Geijtenbeek TBH, Takahashi H, E-cadherin interactions are required for Langerhans cell differentiation. EUR J IMMUNOL 2013;43 (1):270-280 [PubMed]
van den Berg LM. The role of C-type lectin receptors in human skin immunity. Immunological interactions between dendritic cells, Langerhans cells and keratinocytes. s.l.: s.n.; 2013. 133p. ISBN 9789462032668 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Geijtenbeek TBH; copromotor(s): )
van den Berg LM, Geijtenbeek TBH, Antiviral immune responses by human langerhans cells and dendritic cells in HIV-1 infection. ADV EXP MED BIOL 2013;762:45-70 [PubMed]
Wevers BA, Geijtenbeek TBH, Gringhuis SI, C-type lectin receptors orchestrate antifungal immunity. FUTURE MICROBIOL 2013;8 (7):839-854 [PubMed]
de Vries RD, Mesman AW, Geijtenbeek TBH, Duprex WP, de Swart RL, The pathogenesis of measles. CURR OPIN VIROL 2012;2 (3):248-255 [PubMed]
Geijtenbeek TBH, Actin' as a Death Signal. IMMUNITY 2012;36 (4):557-559 [PubMed]
Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TBH, Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1 beta via a noncanonical caspase-8 inflammasome. NAT IMMUNOL 2012;13 (3):246-U63 [PubMed]
Mesman AW, de Vries RD, McQuaid S, Duprex WP, de Swart RL, Geijtenbeek TBH, A Prominent Role for DC-SIGN(+) Dendritic Cells in Initiation and Dissemination of Measles Virus Infection in Non-Human Primates. PLOS ONE 2012;7 (12):e49573 [PubMed]
Mesman AW, Geijtenbeek TB, Pattern Recognition Receptors in HIV Transmission. FRONTIERS IMMUNOL 2012;3:59 [PubMed]
Sorvillo N, Pos W, van den Berg LM, Fijnheer R, Martinez-Pomares L, Geijtenbeek TB, Herczenik E, Voorberg J, The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells. BLOOD 2012;119 (16):3828-3835 [PubMed]
van den Berg LM, Gringhuis SI, Geijtenbeek TBH, An evolutionary perspective on C-type lectins in infection and immunity. ANN NY ACAD SCI 2012;1253:149-158 [PubMed]
van der Vlist M. C-type lectins on dendritic cells. Bittersweet interactions with viruses. s.l.: s.n.; 2012. 151p. ISBN 9789085708308 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Geijtenbeek TBH; copromotor(s): Gringhuis SI)
de Witte L, Bobardt MD, Chatterji U, van Loenen FB, Verjans GMGM, Geijtenbeek TBH, Gallay PA, HSV neutralization by the microbicidal candidate C5A. PLOS ONE 2011;6 (5):e18917 [PubMed]
Gringhuis SI, Wevers BA, Kaptein TM, van Capel TMM, Theelen B, Boekhout T, de Jong EC, Geijtenbeek TBH, Selective C-Rel Activation via Malt1 Controls Anti-Fungal T-H-17 Immunity by Dectin-1 and Dectin-2. PLOS PATHOG 2011;7 (1):e1001259 [PubMed]
Lemon K, de Vries RD, Mesman AW, McQuaid S, van Amerongen G, Yüksel S, Ludlow M, Rennick LJ, Kuiken T, Rima BK, Geijtenbeek TBH, Osterhaus ADME, Duprex WP, de Swart RL, Early Target Cells of Measles Virus after Aerosol Infection of Non-Human Primates. PLOS PATHOG 2011;7 (1):e1001263 [PubMed]
van den Berg LM, de Jong MAWP, Witte Ld, Ulrich MMW, Geijtenbeek TBH, Burn injury suppresses human dermal dendritic cell and Langerhans cell function. CELL IMMUNOL 2011;268 (1):29-36 [PubMed]
van der Vlist M, de Witte L, de Vries RD, Litjens M, de Jong MAWP, Fluitsma D, de Swart RL, Geijtenbeek TBH, Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4⁺ T cells but are incapable of cross-presentation. EUR J IMMUNOL 2011;41 (9):2619-2631 [PubMed]
van der Vlist M, van der Aar AMG, Gringhuis SI, Geijtenbeek TBH, Innate signaling in HIV-1 infection of dendritic cells. CURR OPIN HIV AIDS 2011;6 (5):348-352 [PubMed]
de Jong MAWP. Langerhans cells and dendritic cells in innate defense against pathogens. Amsterdam: s.n.; 2010. 229p. Proefschrift Vrije Universiteit Amsterdam, MCBI, onderzoek in AMC-UvA. (Promotor(s): Geijtenbeek TBH, van Kooyk Y; copromotor(s): )
de Jong MAWP, de Witte L, Geijtenbeek TBH, Isolation of immature primary Langerhans cells from human epidermal skin. METHODS MOL BIOL 2010;595:55-65 [PubMed]
de Jong MAWP, de Witte L, Santegoets SJAM, Fluitsma D, Taylor ME, de Gruijl TD, Geijtenbeek TBH, Mutz-3-derived Langerhans cells are a model to study HIV-1 transmission and potential inhibitors. J LEUKOCYTE BIOL 2010;87 (4):637-643 [PubMed]
de Jong MAWP, de Witte L, Taylor ME, Geijtenbeek TBH, Herpes Simplex Virus Type 2 Enhances HIV-1 Susceptibility by Affecting Langerhans Cell Function. J IMMUNOL 2010;185 (3):1633-1641 [PubMed]
de Jong MAWP, Geijtenbeek TBH, Langerhans cells in innate defense against pathogens. TRENDS IMMUNOL 2010;31 (12):452-459 [PubMed]
de Jong MAWP, Vriend LEM, Theelen B, Taylor ME, Fluitsma D, Boekhout T, Geijtenbeek TBH, C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi. MOL IMMUNOL 2010;47 (6):1216-1225 [PubMed]
den Dunnen J, Gringhuis SI, Geijtenbeek TBH, Dusting the sugar fingerprint: C-type lectin signaling in adaptive immunity. IMMUNOL LETT 2010;128 (1):12-16 [PubMed]
Geijtenbeek TBH, Host DNase TREX1 hides HIV from DNA sensors. NAT IMMUNOL 2010;11 (11):979-980 [PubMed]
Gringhuis SI, Geijtenbeek TBH, Carbohydrate signaling by C-type lectin DC-SIGN affects NF-kappaB activity. METHOD ENZYMOL 2010;480:151-164 [PubMed]
Gringhuis SI, van der Vlist M, van den Berg LM, den Dunnen J, Litjens M, Geijtenbeek TBH, HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. NAT IMMUNOL 2010;11 (5):419-U81 [PubMed]
Nguyen DT, de Witte L, Ludlow M, Yüksel S, Wiesmüller KH, Geijtenbeek TBH, Osterhaus ADME, de Swart RL, The Synthetic Bacterial Lipopeptide Pam3CSK4 Modulates Respiratory Syncytial Virus Infection Independent of TLR Activation. PLOS PATHOG 2010;6 (8):e1001049 [PubMed]
van der Vlist M, Geijtenbeek TBH, Langerin functions as an antiviral receptor on Langerhans cells. IMMUNOL CELL BIOL 2010;88 (4):410-415 [PubMed]
de Jong MAWP, Geijtenbeek TBH, Human immunodeficiency virus-1 acquisition in genital mucosa: Langerhans cells as key-players. J INTERN MED 2009;265 (1):18-28 [PubMed]
den Dunnen J. C-type lectin signaling in response to pathogens. S.l.: s.n.; 2009. 194p. ISBN 978 90 8570 286 3 Proefschrift Vrije Universiteit Amsterdam, MCBI. (Promotor(s): van Kooyk Y; copromotor(s): Geijtenbeek TBH, Gringhuis SI)
den Dunnen J, Gringhuis SI, Geijtenbeek TBH, Innate signaling by the C-type lectin DC-SIGN dictates immune responses. CANCER IMMUNOL IMMUN 2009;58 (7):1149-1157 [PubMed]
de Witte L, de Jong MAWP, den Dunnen J, van Kooyk Y, Geijtenbeek TBH, Identification of pathogen receptors on dendritic cells to understand their function and to identify new drug targets. METHODS MOL BIOL 2009;531:267-285 [PubMed]
Geijtenbeek TBH, den Dunnen J, Gringhuis SI, Pathogen recognition by DC-SIGN shapes adaptive immunity. FUTURE MICROBIOL 2009;4 (7):879-890 [PubMed]
Geijtenbeek TBH, Gringhuis SI, Signalling through C-type lectin receptors: shaping immune responses. NAT REV IMMUNOL 2009;9 (7):465-479 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TBH, Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. NAT IMMUNOL 2009;10 (10):1081-U58 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SCM, Geijtenbeek TBH, Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. NAT IMMUNOL 2009;10 (2):203-213 [PubMed]
Kooij G, Backer R, Koning JJ, Reijerkerk A, van Horssen J, van der Pol SMA, Drexhage J, Schinkel A, Dijkstra CD, den Haan JMM, Geijtenbeek TBH, de Vries HE, P-glycoprotein acts as an immunomodulator during neuroinflammation. PLOS ONE 2009;4 (12):e8212 [PubMed]
Op den Brouw ML, Binda RS, Geijtenbeek TBH, Janssen HLA, Woltman AM, The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells. VIROLOGY 2009;393 (1):84-90 [PubMed]
Saeland E, de Jong MAWP, Nabatov AA, Kalay H, Geijtenbeek TBH, van Kooyk Y, MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells. MOL IMMUNOL 2009;46 (11-12):2309-2316 [PubMed]
Appelmelk BJ, den Dunnen J, Driessen NN, Ummels R, Pak M, Nigou J, Larrouy-Maumus G, Gurcha SS, Movahedzadeh F, Geurtsen J, Brown EJ, Eysink Smeets MM, Besra GS, Willemsen PTJ, Lowary TL, van Kooyk Y, Maaskant JJ, Stoker NG, van der Ley P, Puzo G, Vandenbroucke-Grauls CMJE, Wieland CW, van der Poll T, Geijtenbeek TBH, van der Sar AM, Bitter W, The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction. CELL MICROBIOL 2008;10 (4):930-944 [PubMed]
Bobardt MD, Cheng G, de Witte L, Selvarajah S, Chatterji U, Sanders-Beer BE, Geijtenbeek TBH, Chisari FV, Gallay PA, Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus. P NATL ACAD SCI USA 2008;105 (14):5525-5530 [PubMed]
Cunningham AL, Carbone F, Geijtenbeek TBH, Langerhans cells and viral immunity. EUR J IMMUNOL 2008;38 (9):2377-2385 [PubMed]
de Jong MAWP, de Witte L, Bolmstedt A, van Kooyk Y, Geijtenbeek TBH, Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN. J GEN VIROL 2008;89 (Part 10):2398-2409 [PubMed]
de Jong MAWP, de Witte L, Oudhoff MJ, Gringhuis SI, Gallay P, Geijtenbeek TBH, TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo. J CLIN INVEST 2008;118 (10):3440-3452 [PubMed]
de Witte LD. Dendritic cells and lymphotropic viruses: Who is fooling whom?. S.l.: s.n.; 2008. 272p. ISBN 978-80-8659-223-4 Proefschrift Vrije Universiteit Amsterdam, MCBI. (Promotor(s): van Kooyk Y; copromotor(s): Geijtenbeek TBH)
de Witte L, de Vries RD, van der Vlist M, Yüksel S, Litjens M, de Swart RL, Geijtenbeek TBH, DC-SIGN and CD150 have distinct roles in transmission of measles virus from dendritic cells to T-lymphocytes. PLOS PATHOG 2008;4 (4):e1000049 [PubMed]
de Witte L, Nabatov A, Geijtenbeek TBH, Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission. TRENDS MOL MED 2008;14 (1):12-19 [PubMed]
García-Vallejo JJ, van Liempt E, da Costa Martins P, Beckers C, van het Hof B, Gringhuis SI, Zwaginga JJ, van Dijk W, Geijtenbeek TBH, van Kooyk Y, van Die I, DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2. MOL IMMUNOL 2008;45 (8):2359-2369 [PubMed]
Hovius JWR, de Jong MAWP, den Dunnen J, Litjens M, Fikrig E, van der Poll T, Gringhuis SI, Geijtenbeek TBH, Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLOS PATHOG 2008;4 (2):e31 [PubMed]
Koppel EA, Litjens M, van den Berg VC, van Kooyk Y, Geijtenbeek TBH, Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae. MOL IMMUNOL 2008;45 (10):2881-2887 [PubMed]
Nabatov AA, de Jong MAWP, de Witte L, Bulgheresi S, Geijtenbeek TBH, C-type lectin Mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+ T cells. VIROLOGY 2008;378 (2):323-328 [PubMed]
Op den Brouw ML, de Jong MAWP, Ludwig IS, van der Molen RG, Janssen HLA, Geijtenbeek TBH, Woltman AM, Branched oligosaccharide structures on HBV prevent interaction with both DC-SIGN and L-SIGN. J VIRAL HEPATITIS 2008;15 (9):675-683 [PubMed]
van Vliet SJ, Paessens LC, Broks-van den Berg VCM, Geijtenbeek TBH, van Kooyk Y, The C-type lectin macrophage galactose-type lectin impedes migration of immature APCs. J IMMUNOL 2008;181 (5):3148-3155 [PubMed]
Dasgupta S, Navarrete AM, Bayry J, Delignat S, Wootla B, André S, Christophe O, Nascimbeni M, Jacquemin M, Martinez-Pomares L, Geijtenbeek TBH, Moris A, Saint-Remy JM, Kazatchkine MD, Kaveri SV, Lacroix-Desmazes S, A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes. P NATL ACAD SCI USA 2007;104 (21):8965-8970 [PubMed]
de Swart RL, Ludlow M, de Witte L, Yanagi Y, van Amerongen G, McQuaid S, Yüksel S, Geijtenbeek TBH, Duprex WP, Osterhaus ADME, Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques. PLOS PATHOG 2007;3 (11):e178 [PubMed]
de Witte L, Bobardt M, Chatterji U, Degeest G, David G, Geijtenbeek TBH, Gallay P, Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1. P NATL ACAD SCI USA 2007;104 (49):19464-19469 [PubMed]
de Witte L, Nabatov A, Pion M, Fluitsma D, de Jong MAWP, de Gruijl T, Piguet V, van Kooyk Y, Geijtenbeek TBH, Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. NAT MED 2007;13 (3):367-371 [PubMed]
de Witte L, Zoughlami Y, Aengeneyndt B, David G, van Kooyk Y, Gissmann L, Geijtenbeek TBH, Binding of human papilloma virus L1 virus-like particles to dendritic cells is mediated through heparan sulfates and induces immune activation. IMMUNOBIOLOGY 2007;212 (9-10):679-691 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van het Hof B, van Kooyk Y, Geijtenbeek TBH, C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. IMMUNITY 2007;26 (5):605-616 [PubMed]
Ludwig IS. C-type lectins L-SIGN and DC-SIGN. S.l.: s.n.; 2007. 192p. ISBN 97 8908 6591 244 Proefschrift Vrije Universiteit Amsterdam, MCBI. (Promotor(s): van Kooyk Y; copromotor(s): Geijtenbeek TBH)
Saeland E, van Vliet SJ, Bäckström M, van den Berg VCM, Geijtenbeek TBH, Meijer GA, van Kooyk Y, The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma. CANCER IMMUNOL IMMUN 2007;56 (8):1225-1236 [PubMed]
van Montfort T, Nabatov AA, Geijtenbeek TBH, Pollakis G, Paxton WA, Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4+ T lymphocytes. J IMMUNOL 2007;178 (5):3177-3185 [PubMed]
van Vliet SJ. Novel insights into MGL-glycan interactions in the immune system. S.l.: s.n.; 2007. 232p. ISBN 978-90-9021574-7 Proefschrift Vrije Universiteit Amsterdam, MCBI. (Promotor(s): van Kooyk Y; copromotor(s): Geijtenbeek TBH)
van Vliet SJ, Aarnoudse CA, Broks-van den Berg VCM, Boks M, Geijtenbeek TBH, van Kooyk Y, MGL-mediated internalization and antigen presentation by dendritic cells: a role for tyrosine-5. EUR J IMMUNOL 2007;37 (8):2075-2081 [PubMed]
van Vliet SJ, den Dunnen J, Gringhuis SI, Geijtenbeek TB, van Kooyk Y, Innate signaling and regulation of Dendritic cell immunity. CURR OPIN IMMUNOL 2007;19 (4):435-440 [PubMed]
Wieland CW, Koppel EA, den Dunnen J, Florquin S, McKenzie ANJ, van Kooyk Y, van der Poll T, Geijtenbeek TBH, Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis. MICROBES INFECT 2007;9 (2):134-141 [PubMed]
de Witte L, Abt M, Schneider-Schaulies S, van Kooyk Y, Geijtenbeek TBH, Measles virus targets DC-SIGN to enhance dendritic cell infection. J VIROL 2006;80 (7):3477-3486 [PubMed]
Koppel EA. The in vivo function of mSIGNR1, a DC-SIGN homologue. S.l.: s.n.; 2006. 159p. ISBN 978-9-08659-005-6 Proefschrift Vrije Universiteit Amsterdam, MCBI. (Promotor(s): van Kooyk Y; copromotor(s): Geijtenbeek TBH)
Lekkerkerker AN, van Kooyk Y, Geijtenbeek TBH, Viral piracy: HIV-1 targets dendritic cells for transmission. CURR HIV RES 2006;4 (2):169-176 [PubMed]
Ludwig IS, Geijtenbeek TBH, van Kooyk Y, Two way communication between neutrophils and dendritic cells. CURR OPIN PHARMACOL 2006;6 (4):408-413 [PubMed]
Naarding MA, Dirac AM, Ludwig IS, Speijer D, Lindquist S, Vestman EL, Stax MJ, Geijtenbeek TBH, Pollakis G, Hernell O, Paxton WA, Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells. ANTIMICROB AGENTS CH 2006;50 (10):3367-3374 [PubMed]
Nabatov AA, van Montfort T, Geijtenbeek TBH, Pollakis G, Paxton WA, Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression. FEBS J 2006;273 (21):4944-4958 [PubMed]
Oosterling SJ, Mels AK, Geijtenbeek TBH, van der Bij GJ, Tuk CW, Vuylsteke RJCLM, van Leeuwen PAM, Meijer GA, Meijer S, Beelen RHJ, van Egmond M, Preoperative granulocyte/macrophage colony-stimulating factor (GM-CSF) increases hepatic dendritic cell numbers and clustering with lymphocytes in colorectal cancer patients. IMMUNOBIOLOGY 2006;211 (6-8):641-649 [PubMed]
van Gisbergen KPJM. DC-SIGN mediates cellular communication of dendritic cells. S.l.: s.n.; 2006. 212p. ISBN 978 90 9020617 2 Proefschrift Vrije Universiteit Amsterdam, MCBI. (Promotor(s): van Kooyk Y; copromotor(s): Geijtenbeek TBH)
van Kooyk Y, Geijtenbeek TBH, Toll-like receptors keep antigen sorting on the right track. IMMUNITY 2006;25 (4):525-527 [PubMed]
van Vliet SJ, Gringhuis SI, Geijtenbeek TBH, van Kooyk Y, Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45. NAT IMMUNOL 2006;7 (11):1200-1208 [PubMed]
van Vliet SJ, van Liempt E, Geijtenbeek TBH, van Kooyk Y, Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets. IMMUNOBIOLOGY 2006;211 (6-8):577-585 [PubMed]
Groot F, Geijtenbeek TBH, Sanders RW, Baldwin CE, Sanchez-Hernandez M, Floris R, van Kooyk Y, de Jong EC, Berkhout B, Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction. J VIROL 2005;79 (5):3009-3015 [PubMed]
Koppel EA, Ludwig IS, Appelmelk BJ, van Kooyk Y, Geijtenbeek TBH, Carbohydrate specificities of the murine DC-SIGN homologue mSIGNR1. IMMUNOBIOLOGY 2005;210 (2-4):195-201 [PubMed]
Koppel EA, Saeland E, de Cooker DJM, van Kooyk Y, Geijtenbeek TBH, DC-SIGN specifically recognizes Streptococcus pneumoniae serotypes 3 and 14. IMMUNOBIOLOGY 2005;210 (2-4):203-210 [PubMed]
Koppel EA, van Gisbergen KPJM, Geijtenbeek TBH, van Kooyk Y, Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation. CELL MICROBIOL 2005;7 (2):157-165 [PubMed]
Koppel EA, Wieland CW, van den Berg VCM, Litjens M, Florquin S, van Kooyk Y, van der Poll T, Geijtenbeek TBH, Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection. EUR J IMMUNOL 2005;35 (10):2962-2969 [PubMed]
Naarding MA, Ludwig IS, Groot F, Berkhout B, Geijtenbeek TBH, Pollakis G, Paxton WA, Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4(+) T lymphocytes. J CLIN INVEST 2005;115 (11):3256-3264 [PubMed]
van Gisbergen KPJM, Aarnoudse CA, Meijer GA, Geijtenbeek TBH, van Kooyk Y, Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin. CANCER RES 2005;65 (13):5935-5944 [PubMed]
van Gisbergen KPJM, Geijtenbeek TBH, van Kooyk Y, Close encounters of neutrophils and DCs. TRENDS IMMUNOL 2005;26 (12):626-631 [PubMed]
van Gisbergen KPJM, Ludwig IS, Geijtenbeek TBH, van Kooyk Y, Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils. FEBS LETT 2005;579 (27):6159-6168 [PubMed]
van Gisbergen KPJM, Paessens LC, Geijtenbeek TBH, van Kooyk Y, Molecular mechanisms that set the stage for DC-T cell engagement. IMMUNOL LETT 2005;97 (2):199-208 [PubMed]
van Gisbergen KPJM, Sanchez-Hernandez M, Geijtenbeek TBH, van Kooyk Y, Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN. J EXP MED 2005;201 (8):1281-1292 [PubMed]
van Vliet SJ, van Liempt E, Saeland E, Aarnoudse CA, Appelmelk B, Irimura T, Geijtenbeek TBH, Blixt O, Alvarez R, van Die I, van Kooyk Y, Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells. INT IMMUNOL 2005;17 (5):661-669 [PubMed]
Arrighi JF, Pion M, Garcia E, Escola JM, van Kooyk Y, Geijtenbeek TB, Piguet V, DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells. J EXP MED 2004;200 (10):1279-1288 [PubMed]
Arrighi JF, Pion M, Wiznerowicz M, Geijtenbeek TB, Garcia E, Abraham S, Leuba F, Dutoit V, Ducrey-Rundquist O, van Kooyk Y, Trono D, Piguet V, Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells. J VIROL 2004;78 (20):10848-10855 [PubMed]
Engering A, van Vliet SJ, Hebeda K, Jackson DG, Prevo R, Singh SK, Geijtenbeek TBH, van Krieken H, van Kooyk Y, Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes. AM J PATHOL 2004;164 (5):1587-1595 [PubMed]
Geijtenbeek TBH, van Vliet SJ, Engering A, 't Hart BA, van Kooyk Y, Self- and nonself-recognition by C-type lectins on dendritic cells. ANNU REV IMMUNOL 2004;22:33-54 [PubMed]
Koppel EA, Ludwig IS, Hernandez MS, Lowary TL, Gadikota RR, Tuzikov AB, Vandenbroucke-Grauls CMJE, van Kooyk Y, Appelmelk BJ, Geijtenbeek TBH, Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1. IMMUNOBIOLOGY 2004;209 (1-2):117-127 [PubMed]
Lekkerkerker AN, Ludwig IS, van Vliet SJ, van Kooyk Y, Geijtenbeek TBH, Potency of HIV-1 envelope glycoprotein gp120 antibodies to inhibit the interaction of DC-SIGN with HIV-1 gp120. VIROLOGY 2004;329 (2):465-476 [PubMed]
Lekkerkerker AN, van Kooyk Y, Geijtenbeek TBH, Mucosal-targeted AIDS vaccines: the next generation?. TRENDS MICROBIOL 2004;12 (10):447-450 [PubMed]
Ludwig IS, Lekkerkerker AN, Depla E, Bosman F, Musters RJP, Depraetere S, van Kooyk Y, Geijtenbeek TBH, Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation. J VIROL 2004;78 (15):8322-8332 [PubMed]
van Kooyk Y, Engering A, Lekkerkerker AN, Ludwig IS, Geijtenbeek TBH, Pathogens use carbohydrates to escape immunity induced by dendritic cells. CURR OPIN IMMUNOL 2004;16 (4):488-493 [PubMed]
van Liempt E, Imberty A, Bank CMC, van Vliet SJ, van Kooyk Y, Geijtenbeek TBH, van Die I, Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens. J BIOL CHEM 2004;279 (32):33161-33167 [PubMed]
Appelmelk BJ, van Die I, van Vliet SJ, Vandenbroucke-Grauls CMJE, Geijtenbeek TBH, van Kooyk Y, Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J IMMUNOL 2003;170 (4):1635-1639 [PubMed]
Geijtenbeek TBH, van Kooyk Y, DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission. CURR TOP MICROBIOL 2003;276:31-54 [PubMed]
Geijtenbeek TBH, van Kooyk Y, Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity. APMIS 2003;111 (7-8):698-714 [PubMed]
Geijtenbeek TBH, van Vliet SJ, Koppel EA, Sanchez-Hernandez M, Vandenbroucke-Grauls CMJE, Appelmelk B, van Kooyk Y, Mycobacteria target DC-SIGN to suppress dendritic cell function. J EXP MED 2003;197 (1):7-17 [PubMed]
Kämmerer U, Eggert AO, Kapp M, McLellan AD, Geijtenbeek TBH, Dietl J, van Kooyk Y, Kämpgen E, Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy. AM J PATHOL 2003;162 (3):887-896 [PubMed]
Stuyt RJL, Netea MG, Geijtenbeek TBH, Kullberg BJ, Dinarello CA, van der Meer JWM, Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes. IMMUNOLOGY 2003;110 (3):329-334 [PubMed]
van Die I, van Vliet SJ, Nyame AK, Cummings RD, Bank CMC, Appelmelk B, Geijtenbeek TBH, van Kooyk Y, The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x. GLYCOBIOLOGY 2003;13 (6):471-478 [PubMed]
van Kooyk Y, Appelmelk B, Geijtenbeek TBH, A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance. TRENDS MOL MED 2003;9 (4):153-159 [PubMed]
van Kooyk Y, Geijtenbeek TBH, DC-SIGN: escape mechanism for pathogens. NAT REV IMMUNOL 2003;3 (9):697-709 [PubMed]
Engering A, Geijtenbeek TBH, van Kooyk Y, Immune escape through C-type lectins on dendritic cells. TRENDS IMMUNOL 2002;23 (10):480-485 [PubMed]
Engering A, Geijtenbeek TBH, van Vliet SJ, Wijers M, van Liempt E, Demaurex N, Lanzavecchia A, Fransen J, Figdor CG, Piguet V, van Kooyk Y, The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J IMMUNOL 2002;168 (5):2118-2126 [PubMed]
Engering A, van Vliet SJ, Geijtenbeek TBH, van Kooyk Y, Subset of DC-SIGN(+) dendritic cells in human blood transmits HIV-1 to T lymphocytes. BLOOD 2002;100 (5):1780-1786 [PubMed]
Geijtenbeek TBH, Engering A, van Kooyk Y, DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J LEUKOCYTE BIOL 2002;71 (6):921-931 [PubMed]
Geijtenbeek TBH, Groot PC, Nolte MA, van Vliet SJ, Gangaram-Panday ST, van Duijnhoven GCF, Kraal G, van Oosterhout AJM, van Kooyk Y, Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. BLOOD 2002;100 (8):2908-2916 [PubMed]
Geijtenbeek TBH, van Duijnhoven GCF, van Vliet SJ, Krieger E, Vriend G, Figdor CG, van Kooyk Y, Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1. J BIOL CHEM 2002;277 (13):11314-11320 [PubMed]
Smits HH, de Jong EC, Schuitemaker JHN, Geijtenbeek TBH, van Kooyk Y, Kapsenberg ML, Wierenga EA, Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development. J IMMUNOL 2002;168 (4):1710-1716 [PubMed]
van Kooyk Y, Geijtenbeek TBH, A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. IMMUNOL REV 2002;186:47-56 [PubMed]
Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, van Vliet SJ, Eilering JB, Martin MP, Wu L, Martin TD, Viebig N, Knolle PA, KewalRamani VN, van Kooyk Y, Carrington M, A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J EXP MED 2001;193 (6):671-678 [PubMed]
Bleijs DA, Geijtenbeek TB, Figdor CG, van Kooyk Y, DC-SIGN and LFA-1: a battle for ligand. TRENDS IMMUNOL 2001;22 (8):457-463 [PubMed]
Geijtenbeek TB, Koopman G, van Duijnhoven GC, van Vliet SJ, van Schijndel AC, Engering A, Heeney JL, van Kooyk Y, Rhesus macaque and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar to human DC-SIGN. IMMUNOL LETT 2001;79 (1-2):101-107 [PubMed]
Geijtenbeek TB, van Vliet SJ, van Duijnhoven GC, Figdor CG, van Kooyk Y, DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review. PLACENTA 2001;22 (Suppl. A):S19-S23 [PubMed]
Geijtenbeek TB, Krooshoop DJ, Bleijs DA, van Vliet SJ, van Duijnhoven GC, Grabovsky V, Alon R, Figdor CG, van Kooyk Y, DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. NAT IMMUNOL 2000;1 (4):353-357 [PubMed]
Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, Figdor CG, van Kooyk Y, DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. CELL 2000;100 (5):587-597 [PubMed]
Geijtenbeek TB, Torensma R, van Vliet SJ, van Duijnhoven GC, Adema GJ, van Kooyk Y, Figdor CG, Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. CELL 2000;100 (5):575-585 [PubMed]
Wanten GJ, Geijtenbeek TB, Raymakers RA, van Kooyk Y, Roos D, Jansen JB, Naber AH, Medium-chain, triglyceride-containing lipid emulsions increase human neutrophil beta2 integrin expression, adhesion, and degranulation. JPEN-PARENTER ENTER 2000;24 (4):228-233 [PubMed]
de Bont N, Geijtenbeek TB, Netea MG, Smilde TJ, Demacker PN, Figdor CG, van der Meer JW, Stalenhoef AF, Integrin mediated adhesion of mononuclear cells from patients with familial hypercholesterolemia. EUR J CLIN INVEST 1999;29 (9):749-757 [PubMed]
Geijtenbeek TB, van Kooyk Y, van Vliet SJ, Renes MH, Raymakers RA, Figdor CG, High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. BLOOD 1999;94 (2):754-764 [PubMed]
Snoek GT, Berrie CP, Geijtenbeek TB, van der Helm HA, Cadeé JA, Iurisci C, Corda D, Wirtz KW, Overexpression of phosphatidylinositol transfer protein alpha in NIH3T3 cells activates a phospholipase A. J BIOL CHEM 1999;274 (50):35393-35399 [PubMed]
Geijtenbeek TB, Smith AJ, Borst P, Wirtz KW, cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene. BIOCHEM J 1996;316 (1):49-55 [PubMed]
Geijtenbeek TB, Westerman J, Heerma W, Wirtz KW, Phosphatidylcholine transfer protein from bovine liver contains highly unsaturated phosphatidylcholine species. FEBS LETT 1996;391 (3):333-335 [PubMed]
Hoffmann RA, Geijtenbeek T, Kamerling JP, Vliegenthart JF, 1H-N.m.r. study of enzymically generated wheat-endosperm arabinoxylan oligosaccharides: structures of hepta- to tetradeca-saccharides containing two or three branched xylose residues. CARBOHYD RES 1992;223:19-44 [PubMed]
Ossendorp BC, Geijtenbeek TB, Wirtz KW, The precursor form of the rat liver non-specific lipid-transfer protein, expressed in Escherichia coli, has lipid transfer activity. FEBS LETT 1992;296 (2):179-183 [PubMed]
Key publications

Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TBH, Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1 beta via a noncanonical caspase-8 inflammasome. NAT IMMUNOL 2012;13 (3):246-U63 [PubMed]
Gringhuis SI, van der Vlist M, van den Berg LM, den Dunnen J, Litjens M, Geijtenbeek TBH, HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. NAT IMMUNOL 2010;11 (5):419-U81 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TBH, Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. NAT IMMUNOL 2009;10 (10):1081-U58 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SCM, Geijtenbeek TBH, Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. NAT IMMUNOL 2009;10 (2):203-213 [PubMed]
Geijtenbeek TBH, Gringhuis SI, Signalling through C-type lectin receptors: shaping immune responses. NAT REV IMMUNOL 2009;9 (7):465-479 [PubMed]


All Publications

Research programmes

C-type lectins in infection and immunity

The research program focuses on the function of pattern recognition receptors and in particular C-type lectins on different dendritic cell (DC) subsets in adaptive immunity and infection in human. We investigate the molecular mechanisms that shape adaptive immunity to different pathogens as well as those mechanisms that are used by pathogens to infect the host. An important signaling pathway is induced by DC-SIGN triggering and this Raf-1 dependent pathway modulates Toll-like receptor signaling through post-translational modification of NF-B p65 and nucleosome remodeling to induce pathogen-tailored immunity (Gringhuis et al. Immunity 2007; Hovius et al. PLoS Pathogen 2007). This Raf-1-dependent signaling pathway is activated by different pathogens such as M. tuberculosis, M. leprae, Candida albicans, Measles virus and HIV-1 indicating that it represents a general mechanism to modulate Toll-like receptor signaling, and this might have important clinical implications. Strikingly, we have recently demonstrated that DC-SIGN induces carbohydrate specific signaling to mannose- and fucose-expressing pathogens (Gringhuis et al. Nat Immunol 2009a) which is a novel mechanism to tailor adaptive immunity. Recent data we have identified the mechanisms that is triggered by DC-SIGN binding to fucose-expressing pathogens, which induces a very strong T helper cell type 2 response (Gringhuis et al. revised). We are currently investigating how these different pathways are involved in infection by HIV-1 (Gringhuis et al. Nat Immunol 2010) and other viruses.
Furthermore, we are investigating how C-type lectin interactions are involved in antifungal defense. We have shown that dectin-1 signaling activates the non-canonical NF-kB subunit RelB which is crucial in induction of T helper type 1 and 17 by DCs to fungi such as C. albicans (Gringhuis et al. Nat Immunol 2009b). Strikingly, recent data show that another C-type lectin Mincle counteracts Th1 induction by suppressing IL-12p35 through IRF1 degradation (Wevers et al. Cell Host&Microbe, in press). These studies suggest that C-type lectin receptors are important players in tailoring adaptive immunity to pathogens and their properties might be used in vaccination studies.
Different DC subsets are important in HIV-1 transmission and our studies have identified Langerin as a HIV-1 receptor on human LCs that protects against HIV-1 infection (de Witte et al. Nat.Med. 2007). These data indicate for the first time that Langerhans cells have an essential role in the innate defense against pathogens (De Jong et al. J.Clin.Invest. 2008). We are now identifying the molecular mechanism of Langerin-mediated restriction of LC infection and HIV-1 transmission.

Faculty
Prof. dr. T.B.H. Geijtenbeek
Dr. S.I. Gringhuis PhD
Dr. E.M.M. van Leeuwen

Postdocs
Dr. D. Amadio
Dr. A. Drewniak PhD
Dr. C.M.S. Ribeiro

PhD Students
N. Hertoghs MSc
Drs. R. Sarrami
J.K. Sprokholt MSc
N.H. van Teijlingen MA
Drs. B.A. Wevers MSc

Others
Ing. T.M. Kaptein MSc
Ing. E.M. Zijlstra-Willems

Other research related activities
  • None reported
Current research funding
  • NWO
  • Parsirus Company
  • Stichting Aidsfonds/SOA AIDS Nederland
  • ZonMw