• Principal Investigator
  • Male

Dr. J.J.T.H. Roelofs MD PhD

Position: Associate professor (UHD)
Main activities: Patient care, Research
Specialisation: Pathologist
foto J.J.T.H. Roelofs is one of the AMC Principal Investigators
Focus of research:

Reciprocal interactions between coagulation and inflammation in the context of kidney diseases.

Current research programmes:

  1. The fibrinolytic system in renal disease
  2. Active Protein C (APC) and the endothelial protein C receptor (EPCR) in acute kidney injury and renal allograft rejection
  3. APC and EPCR in antiphospholipid antibody-induced renal thrombotic microangiopathy
  4. Platelets and platelet-derived microparticles (PMP) in acute kidney injury and renal allograft rejection
AMC themes: Cardiovascular Diseases, Infection & Immunity
Departments: Pathology
Anas AA, Yang J, Daan de Boer J, Roelofs JJTH, Hou B, de Vos AF, van der Poll T, General, but not myeloid or type II lung epithelial cell, myeloid differentiation factor 88 deficiency abrogates house dust mite induced allergic lung inflammation. CLIN EXP IMMUNOL 2017;187 (2):204-212 [PubMed]
Bouatou Y, Kers J, Chevalier-Florquin MSN, Claessen N, Nguyen TQ, Damman J, Proenca H, Roelofs JJTH, Florquin S, Diagnostic accuracy of immunofluorescence versus immunoperoxidase staining to distinguish immune complex-mediated glomerulonephritis and C3 dominant glomerulopathy. HISTOPATHOLOGY 2017;ahead of print [PubMed]
Claushuis TAM, de Stoppelaar SF, Stroo I, Roelofs JJTH, Ottenhoff R, van der Poll T, van't Veer C, Thrombin contributes to protective immunity in pneumonia-derived sepsis via fibrin polymerization and platelet-neutrophil interactions. J THROMB HAEMOST 2017;15 (4):744-757 [PubMed]
d'Hooghe JNS, Goorsenberg AWM, de Bruin DM, Roelofs JJTH, Annema JT, Bonta PI, Optical coherence tomography for identification and quantification of human airway wall layers. PLOS ONE 2017;12 (10):e0184145 [PubMed]
Ding C, van't Veer C, Roelofs JJTH, Shukla M, McCrae KR, Revenko AS, Crosby J, van der Poll T, Limited role of kininogen in the host response during gram-negative pneumonia derived sepsis. AM J PHYSIOL-LUNG C 2017;ahead of print [PubMed]
Gorter RR, Wassenaar ECE, de Boer OJ, Bakx R, Roelofs JJTH, Bunders MJ, van Heurn LWE, Heij HA, Composition of the cellular infiltrate in patients with simple and complex appendicitis. J SURG RES 2017;214:190-196 [PubMed]
Helmerhorst HJF, Schouten LRA, Wagenaar GTM, Juffermans NP, Roelofs JJTH, Schultz MJ, de Jonge E, van Westerloo DJ, Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes. INTENSIVE CARE MED EXP 2017;5 (1):27 [PubMed]
Jansen MPB, Emal D, Teske GJD, Dessing MC, Florquin S, Roelofs JJTH, Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps. KIDNEY INT 2017;91 (2):352-364 [PubMed]
Jansen MPB, Pulskens WP, Butter LM, Florquin S, Juffermans NP, Roelofs JJTH, Leemans JC, Mitochondrial DNA is Released in Urine of Sirs Patients with Acute Kidney Injury and Correlates with Severity of Renal Dysfunction. SHOCK 2017;ahead of print [PubMed]
Lankelma JM, Birnie E, Weehuizen TAF, Scicluna BP, Belzer C, Houtkooper RH, Roelofs JJTH, de Vos AF, van der Poll T, Budding AE, Wiersinga WJ, The gut microbiota as a modulator of innate immunity during melioidosis. PLOS NEGLECT TROP D 2017;11 (4):e0005548 [PubMed]
Lankelma JM, Wagemakers A, Birnie E, Haak BW, Trentelman JJA, Weehuizen TAF, Ersöz J, Roelofs JJTH, Hovius JW, Wiersinga WJ, Bins AD, Rapid DNA vaccination against Burkholderia pseudomallei flagellin by tattoo or intranasal application. VIRULENCE 2017;ahead of print [PubMed]
Lin C, Majoor CJ , Roelofs JJTH, de Kruif MD, Horlings HM, Borensztajn K, Spek CA, Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer. BMC CANCER 2017;17 (1):113 [PubMed]
Ochodnicky P, Lattenist L, Ahdi M, Kers J, Uil M, Claessen N, Leemans JC, Florquin S, Meijers JCM, Gerdes VEA, Roelofs JJTH, Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy. AM J PATHOL 2017;187 (9):1971-1983 [PubMed]
Straat M, Tuip A, Klei TRL, Beuger BM, Roelofs JJTH, van Bruggen R, Juffermans NP, ENDOTOXEMIA RESULTS IN TRAPPING OF TRANSFUSED RED BLOOD CELLS IN LUNGS WITH ASSOCIATED LUNG INJURY. SHOCK 2017;48 (4):484-489 [PubMed]
Stroo I, Yang J, Anas AA, de Boer JD, van Mierlo G, Roem D, Wouters D, Engel R, Roelofs JJTH, van 't Veer C, van der Poll T, Zeerleder S, Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice. PLOS ONE 2017;12 (10):e0186652 [PubMed]
Stroo I, Yang J, de Boer JD, Roelofs JJTH, van 't Veer C, Castellino FJ, Zeerleder S, van der Poll T, Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII. AM J PHYSIOL-LUNG C 2017;312 (2):L163-L171 [PubMed]
Stroo I, Zeerleder S, Ding C, Luken BM, Roelofs JJTH, de Boer OJ, Meijers JCM, Castellino FJ, van 't Veer C, van der Poll T, Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation. THROMB HAEMOSTASIS 2017;117 (8):1601-1614 [PubMed]
van den Boogaard FE, Hofstra JJ, Brands X, Levi MM, Roelofs JJTH, Zaat SAJ, van't Veer C, van der Poll T, Schultz MJ, Nebulized Recombinant Human Tissue Factor Pathway Inhibitor Attenuates Coagulation and Exerts Modest Anti-inflammatory Effects in Rat Models of Lung Injury. J AEROSOL MED PULM D 2017;30 (2):91-99 [PubMed]
Weehuizen TAF, Birnie E, Ferwerda B, Roelofs JJTH, de Vos AF, Grobusch MP, Wiersinga WJ, Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice. AM J TROP MED HYG 2017;96 (6):1365-1369 [PubMed]
de Beer F, Lagrand W, Glas GJ, Beurskens CJP, van Mierlo G, Wouters D, Zeerleder S, Roelofs JJTH, Juffermans NP, Horn J, Schultz MJ, Nebulized C1-Esterase Inhibitor does not Reduce Pulmonary Complement Activation in Rats with Severe Streptococcus Pneumoniae Pneumonia. CELL BIOCHEM BIOPHYS 2016;74 (4):545-552 [PubMed]
Heinsbroek SEM, Squadrito ML, Schilderink R, Hilbers FW, Verseijden C, Hofmann M, Helmke A, Boon L, Wildenberg ME, Roelofs JJTH, Ponsioen CY, Peters CP, te Velde AA, Gordon S, de Palma M, de Jonge WJ, miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation. MUCOSAL IMMUNOL 2016;9 (4):960-973 [PubMed]
Hoekman DR, Roelofs JJTH, van Schuppen J, Schonenberg-Meinema D, D'Haens GR, Benninga MA, Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease. CLIN J GASTROENTEROL 2016;9 (2):73-78 [PubMed]
Hoelbeek J, Duivenvoorden R, de Boer OJ, Claessen N, van den Bergh Weerman MA, Roelofs JJTH, Kers J, ten Berge IJM, Florquin S, Unique Renal Manifestation of Type I Cryoglobulinemia, With Massive Crystalloid Deposits in Glomerular Histiocytes, Podocytes, and Endothelial Cells. AM J CLIN PATHOL 2016;145 (2):282-285 [PubMed]
Lattenist L. The Protein C system in renal disease. S.l.: s.n.; 2016. 213p. ISBN 978-94-91602-62-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Florquin S; copromotor(s): Roelofs JJTH)
Lattenist L, Jansen MPB, Teske G, Claessen N, Meijers JCM, Rezaie AR, Esmon CT, Florquin S, Roelofs JJTH, Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties. THROMB HAEMOSTASIS 2016;116 (1):124-133 [PubMed]
Lattenist L, Ochodnický P, Ahdi M, Claessen N, Leemans JC, Satchell SC, Florquin S, Gerdes VE, Roelofs JJTH, Renal endothelial protein C receptor expression and shedding during diabetic nephropathy. J THROMB HAEMOST 2016;14 (6):1171-1182 [PubMed]
Schouten LRA, Helmerhorst HJF, Wagenaar GTM, Haltenhof T, Lutter R, Roelofs JJTH, van Woensel JBM, van Kaam AHLC, Bos AP, Schultz MJ, Walther T, Wösten-van Asperen RM, Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats. CRIT CARE MED 2016;44 (12):e1226-e1235 [PubMed]
Schuijt TJ, Lankelma JM, Scicluna BP, de Sousa E Melo F, Roelofs JJTH, de Boer JD, Hoogendijk AJ, de Beer R, de Vos A, Belzer C, de Vos WM, van der Poll T, Wiersinga WJ, The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. GUT 2016;65 (4):575-583 [PubMed]
van den Boogaard FE, van Gisbergen KPJM, Vernooy JH, Medema JP, Roelofs JJTH, van Zoelen MAD, Endeman H, Biesma DH, Boon L, van't Veer C, de Vos AF, van der Poll T, Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia. AM J PHYSIOL-LUNG C 2016;311 (2):L507-L516 [PubMed]
Weehuizen TAF, Hommes TJ, Lankelma JM, de Jong HK, Roelofs JJTH, de Vos AF, Colonna M, van der Poll T, Wiersinga WJ, Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis. PLOS NEGLECT TROP D 2016;10 (6):e0004747 [PubMed]
Weehuizen TAF, Lankelma JM, de Jong HK, de Boer OJ, Roelofs JJTH, Day NP, Gram H, de Vos AF, Wiersinga WJ, Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis. SHOCK 2016;46 (5):566-574 [PubMed]
Yapici Ü, Kers J, Slavujevic-Letic I, Stokman G, Roelofs JJTH, van Aalderen MC, Groothoff JW, de Boer OJ, van der Pant KAMI, Claessen N, Hilbrands LB, Bemelman FJ, ten Berge IJM, Florquin S, Intragraft Blood Dendritic Cell Antigen-1-Positive Myeloid Dendritic Cells Increase during BK Polyomavirus-Associated Nephropathy. J AM SOC NEPHROL 2016;27 (8):2502-2510 [PubMed]
de Boer JD, Berkhout LC, de Stoppelaar SF, Yang J, Ottenhoff R, Meijers JCM, Roelofs JJTH, van't Veer C, van der Poll T, Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice. AM J PHYSIOL-LUNG C 2015;309 (8):L768-L775 [PubMed]
de Jong HK, Achouiti A, Koh GCKW, Parry CM, Baker S, Faiz MA, van Dissel JT, Vollaard AM, van Leeuwen EMM, Roelofs JJTH, de Vos AF, Roth J, van der Poll T, Vogl T, Wiersinga WJ, Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model. PLOS NEGLECT TROP D 2015;9 (4):e0003663 [PubMed]
de Stoppelaar SF, Claushuis TAM, Jansen MPB, Hou B, Roelofs JJTH, van 't Veer C, van der Poll T, The role of platelet MyD88 in host response during gram-negative sepsis. J THROMB HAEMOST 2015;13 (9):1709-1720 [PubMed]
de Stoppelaar SF, van't Veer C, Roelofs JJTH, Claushuis TAM, de Boer OJ, Tanck MWT, Hoogendijk AJ, van der Poll T, Platelet and endothelial cell P-selectin are required for host defense against Klebsiella pneumoniae-induced pneumosepsis. J THROMB HAEMOST 2015;13 (6):1128-1138 [PubMed]
Kurakula K, Vos M, Logiantara A, Roelofs JJ, Nieuwenhuis MA, Koppelman GH, Postma DS, van Rijt LS, de Vries CJM, Nuclear Receptor Nur77 Attenuates Airway Inflammation in Mice by Suppressing NF-κB Activity in Lung Epithelial Cells. J IMMUNOL 2015;195 (4):1388-1398 [PubMed]
Kurakula K, Vos M, Logiantara A, Roelofs JJTH, Nieuwenhuis MA, Koppelman GH, Postma DS, Brandsma CA, Sin DD, Bossé Y, Nickle DC, van Rijt LS, de Vries CJM, Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper-responsiveness. ALLERGY 2015;70 (12):1531-1544 [PubMed]
Lattenist L, Teske G, Claessen N, Florquin S, Conway EM, Roelofs JJTH, The lectin like domain of thrombomodulin is involved in the defence against pyelonephritis. THROMB RES 2015;136 (6):1325-1331 [PubMed]
Oosterveld MJS, Garrelfs MR, Hoppe B, Florquin S, Roelofs JJTH, van den Heuvel LP, Amann K, Davin JC, Bouts AHM, Schriemer PJ, Groothoff JW, Eculizumab in Pediatric Dense Deposit Disease. CLIN J AM SOC NEPHRO 2015;10 (10):1773-1782 [PubMed]
Sentís A, Kers J, Yapici U, Claessen N, Roelofs JJTH, Bemelman FJ, ten Berge IJM, Florquin S, The prognostic significance of glomerular infiltrating leukocytes during acute renal allograft rejection. TRANSPL IMMUNOL 2015;33 (3):168-175 [PubMed]
Tudpor K, van der Eerden BCJ, Jongwattanapisan P, Roelofs JJTH, van Leeuwen JPTM, Bindels RJM, Hoenderop JGJ, Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio. BONE 2015;72:14-22 [PubMed]
van den Boogaard FE, Hofstra JJ, van 't Veer C, Levi MM, Roelofs JJTH, van der Poll T, Schultz MJ, Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia. PLOS ONE 2015;10 (5):e0127261 [PubMed]
van den Boogaard FE, Schouten M, de Stoppelaar SF, Roelofs JJTH, Brands X, Schultz MJ, van't Veer C, van der Poll T, Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia. CRIT CARE MED 2015;43 (3):e75-e83 [PubMed]
van den Boogaard FE, van 't Veer C, Roelofs JJTH, Meijers JCM, Schultz MJ, Broze GJ Jr, van der Poll T, Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia. THROMB HAEMOSTASIS 2015;114 (1):115-122 [PubMed]
Beurskens CJ, Aslami H, de Beer FM, Roelofs JJTH, Vroom MB, Juffermans NP, Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome. INTENSIVE CARE MED EXP 2014;2 (1):13 [PubMed]
de Beer FM, Aslami H, Hoeksma J, van Mierlo G, Wouters D, Zeerleder S, Roelofs JJTH, Juffermans NP, Schultz MJ, Lagrand WK, Plasma-derived human C1-esterase inhibitor does not prevent mechanical ventilation-induced pulmonary complement activation in a rat model of Streptococcus pneumoniae pneumonia. CELL BIOCHEM BIOPHYS 2014;70 (2):795-803 [PubMed]
de Boer JD, Kager LM, Roelofs JJTH, Meijers JCM, de Boer OJ, Weiler H, Isermann B, van 't Veer C, van der Poll T, Overexpression of activated protein C hampers bacterial dissemination during pneumococcal pneumonia. BMC INFECT DIS 2014;14 (1):559 [PubMed]
de Boer JD, van't Veer C, Stroo I, van der Meer AJ, de Vos AF, van der Zee JS, Roelofs JJTH, van der Poll T, Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation. INNATE IMMUN-LONDON 2014;20 (6):618-625 [PubMed]
de Boer JD, Yang J, van den Boogaard FE, Hoogendijk AJ, de Beer R, van der Zee JS, Roelofs JJTH, van 't Veer C, de Vos AF, van der Poll T, Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment. J INNATE IMMUN 2014;6 (2):219-226 [PubMed]
de Jong HK, Koh GCKW, Achouiti A, van der Meer AJ, Bulder I, Stephan F, Roelofs JJTH, Day NPJ, Peacock SJ, Zeerleder S, Wiersinga WJ, Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis). INTENSIVE CARE MED EXP 2014;2 (1):21 [PubMed]
de Jong HK, Koh GCKW, van Lieshout MHP, Roelofs JJTH, van Dissel JT, van der Poll T, Wiersinga WJ, Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection. BMC IMMUNOL 2014;15 (1):30 [PubMed]
de Stoppelaar SF, van 't Veer C, Claushuis TAM, Albersen BJA, Roelofs JJTH, van der Poll T, Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice. BLOOD 2014;124 (25):3781-3790 [PubMed]
Goeijenbier M, van Gorp ECM, van den Brand JMA, Stittelaar K, Bakhtiari K, Roelofs JJTH, van Amerongen G, Kuiken T, Martina BEE, Meijers JCM, Osterhaus ADME, Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets. BMC MICROBIOL 2014;14 (1):134 [PubMed]
Heijmans J, Wielenga MCB, Rosekrans SL, van Lidth de Jeude JF, Roelofs J, Groothuis P, Ederveen A, de Jonge-Muller ESM, Biemond I, Hardwick JCH, D'Haens G, Hommes DW, Muncan V , van den Brink GR, Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer. GUT 2014;63 (2):310-316 [PubMed]
Kager LM, de Vos AF, Roelofs JJTH, van der Loos CM, de Boer OJ, van't Veer C, Conway EM, van der Poll T, The thrombomodulin lectin-like domain does not change host responses to tuberculosis. THROMB HAEMOSTASIS 2014;111 (2):345-353 [PubMed]
Kager LM, Runge JH, Nederveen AJ, Roelofs JJTH, Stoker J, Maas M, van der Poll T, A new murine model to study musculoskeletal tuberculosis (short communication). TUBERCULOSIS 2014;94 (3):306-310 [PubMed]
Kager LM, Wiersinga WJ, Roelofs JJTH, de Boer OJ, Weiler H, van 't Veer C, van der Poll T, A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis). PLOS NEGLECT TROP D 2014;8 (4):e2819 [PubMed]
Kager LM, Wiersinga WJ, Roelofs JJTH, Stroo I, Achouiti A, van 't Veer C, Conway EM, van der Poll T, Mice Lacking the Lectin-Like Domain of Thrombomodulin Are Protected Against Melioidosis. CRIT CARE MED 2014;42 (3):E221-E230 [PubMed]
Kager LM, Wiersinga WJ, Roelofs JJTH, van 't Veer C, van der Poll T, Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis). MICROBES INFECT 2014;16 (2):171-174 [PubMed]
Kuipers MT, Aslami H, Tuinman PR, Tuip-de Boer AM, Jongsma G, van der Sluijs KF, Choi G, Wolthuis EK, Roelofs JJTH, Bresser P, Schultz MJ, van der Poll T, Wieland CW, The receptor for advanced glycation end products in ventilator-induced lung injury. INTENSIVE CARE MED EXP 2014;2 (1):22 [PubMed]
Müller MCA, Stroo I, Wouters D, Zeerleder SS, Roelofs JJTH, Boon L, Vroom MB, Juffermans NP, The effect of C1-inhibitor in a murine model of transfusion-related acute lung injury. VOX SANG 2014;107 (1):71-75 [PubMed]
Müller MCA , Tuinman PR, van der Sluijs KF, Boon L, Roelofs JJ, Vroom MB, Juffermans NP, Methylprednisolone fails to attenuate lung injury in a mouse model of transfusion related acute lung injury. TRANSFUSION 2014;54 (4):996-1001 [PubMed]
Schouten M, de Boer JD, Kager LM, Roelofs JJTH, Meijers JCM, Esmon CT, Levi M, van 't Veer C, van der Poll T, The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis. THROMB HAEMOSTASIS 2014;111 (5):970-980 [PubMed]
Shi K, Queiroz KCS, Roelofs JJTH, van Noesel CJM, Richel DJ, Spek CA, Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model. J PATHOL 2014;234 (3):398-409 [PubMed]
Tielbeek JAW, Ziech MLW, Li Z, Lavini C, Bipat S, Bemelman WA, Roelofs JJTH, Ponsioen CY, Vos FM, Stoker J, Evaluation of conventional, dynamic contrast enhanced and diffusion weighted MRI for quantitative Crohn's disease assessment with histopathology of surgical specimens. EUR RADIOL 2014;24 (3):619-629 [PubMed]
van den Boogaard FE, Brands X, Roelofs JJTH, de Beer R, de Boer OJ, van 't Veer C, van der Poll T, Mast cells impair host defense during murine Streptococcus pneumoniae pneumonia. J INFECT DIS 2014;210 (9):1376-1384 [PubMed]
van Montfoort ML, Kuijpers MJE, Knaup VL, Bhanot S, Monia BP, Roelofs JJTH, Heemskerk JWM, Meijers JCM, Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques. ARTERIOSCL THROM VAS 2014;34 (8):1668-1673 [PubMed]
Vergouwen MDI, Knaup VL, Roelofs JJTH, de Boer OJ, Meijers JCM, Effect of recombinant ADAMTS-13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage. J THROMB HAEMOST 2014;12 (6):943-947 [PubMed]
Ziech MLW, Hummel TZ, Smets AMJB, Nievelstein RAJ, Lavini C, Caan MWA, Nederveen AJ, Roelofs JJTH, Bipat S, Benninga MA, Kindermann A, Stoker J, Accuracy of abdominal ultrasound and MRI for detection of Crohn disease and ulcerative colitis in children. PEDIATR RADIOL 2014;44 (11):1370-1378 [PubMed]
Aslami H, Beurskens CJP, de Beer FM, Kuipers MT, Roelofs JJTH, Hegeman MA, van der Sluijs KF, Schultz MJ, Juffermans NP, A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion. CYTOKINE 2013;61 (2):614-621 [PubMed]
Aslami H, Pulskens WP, Kuipers MT, Bos AP, van Kuilenburg ABP, Wanders RJA, Roelofsen J, Roelofs JJTH, Kerindongo RP, Beurskens CJP, Schultz MJ, Kulik W, Weber NC, Juffermans NP, Hydrogen sulfide donor NaHS reduces organ injury in a rat model of pneumococcal pneumosepsis, associated with improved bio-energetic status. PLOS ONE 2013;8 (5):e63497 [PubMed]
Daan de Boer J, Roelofs JJTH, de Vos AF, de Beer R, Schouten M, Hommes TJ, Hoogendijk AJ, de Boer OJ, Stroo I, van der Zee JS, Veer CVt, van der Poll T, Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice. AM J RESP CELL MOL 2013;48 (3):382-389 [PubMed]
de Stoppelaar SF, Bootsma HJ, Zomer A, Roelofs JJTH, Hermans PWM, van 't Veer C, van der Poll T, Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia. PLOS ONE 2013;8 (11):e80062 [PubMed]
de Stoppelaar SF, van't Veer C, van den Boogaard FE, Nieuwland R, Hoogendijk AJ, de Boer OJ, Roelofs JJTH, van der Poll T, Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice. THROMB HAEMOSTASIS 2013;110 (3):582-592 [PubMed]
Hegeman MA, Hemmes SNT, Kuipers MT, Bos LDJ, Jongsma G, Roelofs JJTH, van der Sluijs KF, Juffermans NP, Vroom MB, Schultz MJ, The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation. CRIT CARE RES PRACT 2013;2013:435236 [PubMed]
Hoekstra LT, Bieze M, Erdogan D, Roelofs JJTH, Beuers UHW, van Gulik TM, Management of giant liver hemangiomas: an update. EXPERT REV GASTROENT 2013;7 (3):263-268 [PubMed]
Hofstra JJ, Cornet AD, Declerck PJ, Dixon B, Aslami H, Vlaar APJ, Roelofs JJ, van der Poll T, Levi M, Schultz MJ, Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury. PLOS ONE 2013;8 (2):e55262 [PubMed]
Kager LM, Roelofs JJTH, de Vos AF, Wieland CW, Schouten M, Meijers JCM, Isermann B, van't Veer C, Esmon CT, van der Poll T, The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis. THROMB HAEMOSTASIS 2013;109 (4):726-737 [PubMed]
Kager LM, Schouten M, Wiersinga WJ, de Boer JD, Lattenist LCW, Roelofs JJTH, Meijers JCM, Levi M, Dondorp AM, Esmon CT, van 't Veer C, van der Poll T, Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis). PLOS NEGLECT TROP D 2013;7 (7):e2306 [PubMed]
Kager LM, Weehuizen TA, Wiersinga WJ, Roelofs JJTH, Meijers JCM, Dondorp AM, van 't Veer C, van der Poll T, Endogenous α2-antiplasmin is protective during severe gram-negative sepsis (melioidosis). AM J RESP CRIT CARE 2013;188 (8):967-975 [PubMed]
Kager LM, Wiersinga WJ, Roelofs JJ, Meijers JCM, Zeerleder SS, Esmon CT, van't Veer C, van der Poll T, Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis). J THROMB HAEMOST 2013;11 (2):282-292 [PubMed]
Kager LM, Wiersinga WJ, Roelofs JJTH, de Boer OJ, Meijers JCM, Isermann B, van't Veer C, van der Poll T, Overexpression of activated protein C is detrimental during severe experimental gram-negative sepsis (melioidosis). CRIT CARE MED 2013;41 (10):e266-e274 [PubMed]
Kuipers MT, Vogl T, Aslami H, Jongsma G, van den Berg E, Vlaar APJ, Roelofs JJTH, Juffermans NP, Schultz MJ, van der Poll T, Roth J, Wieland CW, High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling. PLOS ONE 2013;8 (7):e68694 [PubMed]
Lattenist L, Kers J, Claessen N, ten Berge IJM, Bemelman FJ, Florquin S, Roelofs JJTH, Renal and urinary levels of endothelial protein C receptor correlate with acute renal allograft rejection. PLOS ONE 2013;8 (5):e64994 [PubMed]
Schouten M, de Boer JD, van 't Veer C, Roelofs JJTH, Meijers JCM, Levi M, Conway EM, van der Poll T, The lectin-like domain of thrombomodulin hampers host defence in pneumococcal pneumonia. EUR RESPIR J 2013;41 (4):935-942 [PubMed]
van Lienden KP, Hoekstra LT, van Trigt JD, Roelofs JJ, van Delden OM, van Gulik TM, Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2 tumor model. HEPATOB PANCREAT DIS 2013;12 (6):622-629 [PubMed]
Vermeij JD, Aslami H, Fluiter K, Roelofs JJ, van den Bergh WM, Juffermans NP, Schultz MJ, van der Sluijs K, van de Beek D, van Westerloo DJ, Traumatic brain injury in rats induces lung injury and systemic immune suppression. J NEUROTRAUM 2013;30 (24):2073-2079 [PubMed]
Aslami H, Kuipers MT, Beurskens CJP, Roelofs JJTH, Schultz MJ, Juffermans NP, Mild hypothermia reduces ventilator-induced lung injury, irrespective of reducing respiratory rate. TRANSL RES 2012;159 (2):110-117 [PubMed]
Beurskens CJP, Aslami H, Kuipers MT, Horn J, Vroom MB, van Kuilenburg ABP, Roelofs JJTH, Schultz MJ, Juffermans NP, Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover. CRIT CARE MED 2012;40 (3):919-926 [PubMed]
Dik K, de Bruijne J, Takkenberg RB, Roelofs JJ, Tempelmans MJ, Dijkgraaf MGW, Gelderblom HC, Reesink HW, Meijers JCM, Jansen PL, Levi M, Factor XIII Val34Leu mutation accelerates the development of fibrosis in patients with chronic hepatitis B and C. HEPATOL RES 2012;42 (7):668-676 [PubMed]
Dik K, de Bruijne J, Takkenberg RB, Roelofs JJ, Tempelmans MJ, Dijkgraaf MGW, Gelderblom HC, Reesink HW, Meijers JCM, Jansen PL, Levi M, Factor XIII Val34Leu mutation and liver fibrosis rate in viral hepatitis Reply. HEPATOL RES 2012;42 (11):1154-1155 [PubMed]
Heinsbroek SEM, Oei A, Roelofs JJTH, Dhawan S, te Velde A, Gordon S, de Jonge WJ, Genetic deletion of dectin-1 does not affect the course of murine experimental colitis. BMC GASTROENTEROL 2012;12 (1):33 [PubMed]
Hoekstra LT, Bieze M, Erdogan D, Roelofs JJTH, Beuers UHW, van Gulik TM, Het reuzenhemangioom in de lever: diagnostiek en behandeling. NED TIJDSCHR GENEESKD 2012;156 (31):A3820 [PubMed]
Hoogendijk AJ, Roelofs JJTH, Duitman J, van Lieshout MHP, Blok DC, van der Poll T, Wieland CW, R-roscovitine Reduces Lung Inflammation Induced by Lipoteichoic Acid and Streptococcus pneumoniae. MOL MED 2012;18 (7):1086-1095 [PubMed]
Kager LM, Wiersinga WJ, Roelofs JJTH, Meijers JCM, Levi M, van't Veer C, van der Poll T, Endogenous tissue-type plasminogen activator impairs host defense during severe experimental gram-negative sepsis (melioidosis). CRIT CARE MED 2012;40 (7):2168-2175 [PubMed]
Kuipers MT, Aslami H, Janczy JR, van der Sluijs KF, Vlaar APJ, Wolthuis EK, Choi G, Roelofs JJTH, Flavell RA, Sutterwala FS, Bresser P, Leemans JC, van der Poll T, Schultz MJ, Wieland CW, Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome. ANESTHESIOLOGY 2012;116 (5):1104-1115 [PubMed]
Kuipers MT, Aslami H, Vlaar APJ, Juffermans NP, Tuip-de Boer AM, Hegeman MA, Jongsma G, Roelofs JJTH, van der Poll T, Schultz MJ, Wieland CW, Pre-Treatment with Allopurinol or Uricase Attenuates Barrier Dysfunction but Not Inflammation during Murine Ventilator-Induced Lung Injury. PLOS ONE 2012;7 (11):e50559 [PubMed]
Kwakernaak AJ, Hazenberg MD, Roelofs JJ, van Noesel CJ, van Oers MH, van Tellingen A, T-lymfoblastair lymfoom zich presenterend als primair renaal lymfoom met acute nierinsufficiëntie. NED TIJDSCHR HEMATOL 2012;9:34
Schouten M, van't Veer C, Roelofs JJTH, Levi M, van der Poll T, Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study. CRIT CARE 2012;16 (6):R238 [PubMed]
van den Esschert JW, van Lienden KP, Alles LK, van Wijk AC, Heger M, Roelofs JJ, van Gulik TM, Liver Regeneration After Portal Vein Embolization Using Absorbable and Permanent Embolization Materials in a Rabbit Model. ANN SURG 2012;255 (2):311-318 [PubMed]
van Lienden KP, van den Esschert JW, Rietkerk M, Heger M, Roelofs JJTH, Lameris JS, van Gulik TM, Short-term Effects of Combined Hepatic Vein Embolization and Portal Vein Embolization for the Induction of Liver Regeneration in a Rabbit Model. J VASC INTERV RADIOL 2012;23 (7):962-967 [PubMed]
Vlaar APJ, Kuipers MT, Hofstra JJ, Wolthuis EK, Wieland CW, Roelofs JJTH, Boon L, Schultz MJ, Lutter R, Juffermans NP, Mechanical ventilation and the titer of antibodies as risk factors for the development of transfusion-related lung injury. CRIT CARE RES PRACT 2012;2012:720950 [PubMed]
Wolthuis EK, Vlaar APJ, Choi G, Roelofs JJTH, Levi M, Juffermans NP, Schultz MJ, Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. CRIT CARE RES PRACT 2012;2012:130410 [PubMed]
Yapici Ü, Roelofs JJTH, Florquin S, The Importance of Testing Anti-IL-17 Antibodies From Different Suppliers. AM J TRANSPLANT 2012;12 (2):504-505 [PubMed]
Cornet AD, Hofstra JJ, Vlaar AP, van den Boogaard FE, Roelofs JJ, van der Poll T, Levi M, Groeneveld ABJ, Schultz MJ, Nebulized anticoagulants limit coagulopathy but not inflammation in pseudomonas aeruginosa-induced pneumonia in rats. SHOCK 2011;36 (4):417-423 [PubMed]
de Graaf W, van den Esschert JW, van Lienden KP, Roelofs JJTH, van Gulik TM, A rabbit model for selective portal vein embolization. J SURG RES 2011;171 (2):486-494 [PubMed]
Kager LM, Wiersinga WJ, Roelofs JJTH, Meijers JCM, Levi M, van't Veer C, van der Poll T, Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis). J THROMB HAEMOST 2011;9 (10):2020-2028 [PubMed]
Kwakernaak AJ, Hazenberg MD, Roelofs JJTH, van Noesel CJM, van Oers MHJ, van Tellingen A, Precursor T-lymphoblastic lymphoma presenting as primary renal lymphoma with acute renal failure. NDT PLUS 2011;4 (5):289-291 [PubMed]
Queiroz KCS, van 't Veer C, van den Berg Y, Duitman J, Versteeg HH, Aberson HL, Groot AP, Verstege MI, Roelofs JJTH, te Velde AA, Spek CA, Tissue factor-dependent chemokine production aggravates experimental colitis. MOL MED 2011;17 (9-10):1119-1126 [PubMed]
Schouten M, de Boer JD, van der Sluijs KF, Roelofs JJTH, van't Veer C, Levi M, Esmon CT, van der Poll T, Impact of Endogenous Protein C on Pulmonary Coagulation and Injury during Lethal H1N1 Influenza in Mice. AM J RESP CELL MOL 2011;45 (4):789-794 [PubMed]
Schouten M, van der Sluijs KF, Roelofs JJTH, Levi M, van't Veer C, van der Poll T, Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza (vol 36, pg 1346, 2010). EUR RESPIR J 2011;37 (3):726
Schouten M, van 't Veer C, Roelofs JJTH, Gerlitz B, Grinnell BW, Levi M, van der Poll T, Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia. THROMB HAEMOSTASIS 2011;106 (6):1189-1196 [PubMed]
Schuijt TJ, Coumou J, Narasimhan S, Dai J, Deponte K, Wouters D, Brouwer M, Oei A, Roelofs JJTH, van Dam AP, van der Poll T, van't Veer C, Hovius JW, Fikrig E, A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. CELL HOST MICROBE 2011;10 (2):136-146 [PubMed]
van den Boogaard FE, Brands X, Schultz MJ, Levi M, Roelofs JJTH, van 't Veer C, van der Poll T, Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia. J THROMB HAEMOST 2011;9 (1):122-132 [PubMed]
van den Esschert JW, van Lienden KP, de Graaf W, Maas MAW, Roelofs JJTH, Heger M, van Gulik TM, Portal vein embolization induces more liver regeneration than portal vein ligation in a standardized rabbit model. SURGERY 2011;149 (3):378-385 [PubMed]
Wolthuis EK, Vlaar APJ, Hofstra JJH, Roelofs JJTH, de Waard V, Juffermans NP, Schultz MJ, Plasminogen activator inhibitor-type I gene deficient mice show reduced influx of neutrophils in ventilator-induced lung injury. CRIT CARE RES PRACT 2011;2011:217896 [PubMed]
Yapici Ü, Kers J, Bemelman FJ, Roelofs JJTH, Groothoff JW, van der Loos CM, van Donselaar-van der Pant KAMI, Idu MM, Claessen N, ten Berge IJM, Florquin S, Interleukin-17 positive cells accumulate in renal allografts during acute rejection and are independent predictors of worse graft outcome. TRANSPL INT 2011;24 (10):1008-1017 [PubMed]
Ziech MLW, Bipat S, Roelofs JJTH, Nio CY, Mearadji B, van Doorn S, Spijkerboer AM, Stoker J, Retrospective comparison of magnetic resonance imaging features and histopathology in Crohn's disease patients. EUR J RADIOL 2011;80 (3):e299-e305 [PubMed]
Aslami H, Heinen A, Roelofs JJTH, Zuurbier CJ, Schultz MJ, Juffermans NP, Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury. INTENS CARE MED 2010;36 (11):1946-1952 [PubMed]
de Graaf W, van Lienden KP, Dinant S, Roelofs JJTH, Busch ORC, Gouma DJ, Bennink RJ, van Gulik TM, Assessment of Future Remnant Liver Function Using Hepatobiliary Scintigraphy in Patients Undergoing Major Liver Resection. J GASTROINTEST SURG 2010;14 (2):369-378 [PubMed]
Hofstra JJ, Vlaar AP, Cornet AD, Dixon B, Roelofs JJ, Choi G, van der Poll T, Levi M, Schultz MJ, Nebulized Anticoagulants Limit Pulmonary Coagulopathy, But Not Inflammation, in a Model of Experimental Lung Injury. J AEROSOL MED PULM D 2010;23 (2):105-111 [PubMed]
Kers J, Xu-Dubois YC, Rondeau E, Claessen N, Idu MM, Roelofs JJTH, Bemelman FJ, ten Berge IJM, Florquin S, Intragraft Tubular Vimentin and CD44 Expression Correlate With Long-Term Renal Allograft Function and Interstitial Fibrosis and Tubular Atrophy. TRANSPLANTATION 2010;90 (5):502-509 [PubMed]
Schouten M, van der Sluijs KF, Gerlitz B, Grinnell BW, Roelofs JJTH, Levi MM, van 't Veer C, van der Poll T, Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study. CRIT CARE 2010;14 (2):R65 [PubMed]
Schouten M, van der Sluijs KF, Roelofs JJTH, Levi M, van't Veer C, van der Poll T, Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza. EUR RESPIR J 2010;36 (6):1346-1354 [PubMed]
Schouten M, van 't Veer C, Roelofs JJ, Levi M, van der Poll T, Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study. CRIT CARE 2010;14 (4):R145 [PubMed]
Schouten M, van 't Veer C, van den Boogaard FE, Gerlitz B, Grinnell BW, Roelofs JJTH, Levi M, van der Poll T, Therapeutic recombinant murine activated protein C attenuates pulmonary coagulopathy and improves survival in murine pneumococcal pneumonia. J INFECT DIS 2010;202 (10):1600-1607 [PubMed]
Verkleij CJN , Roelofs JJTH, Havik SR, Meijers JCM, Marx PF, The role of thrombin-activatable fibrinolysis inhibitor in diabetic wound healing. THROMB RES 2010;126 (5):442-446 [PubMed]
Vlaar APJ, Hofstra JJ, Kulik W, van Lenthe H, Nieuwland R, Schultz MJ, Levi MM, Roelofs JJTH, Tool ATJ, de Korte D, Juffermans NP, Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model. BLOOD 2010;116 (8):1360-1368 [PubMed]
Vlaar APJ, Wolthuis EK, Hofstra JJ, Roelofs JJTH, Boon L, Schultz MJ, Lutter R, Juffermans NP, Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC-I class antibodies. INTENS CARE MED 2010;36 (5):879-887 [PubMed]
Wiersinga WJ, Kager LM, Hovius JWR, van der Windt GJW, de Vos AF, Meijers JCM, Roelofs JJ, Dondorp A, Levi M, Day NP, Peacock SJ, van der Poll T, Urokinase Receptor Is Necessary for Bacterial Defense against Pneumonia-Derived Septic Melioidosis by Facilitating Phagocytosis. J IMMUNOL 2010;184 (6):3079-3086 [PubMed]
Hovius JWR, Bijlsma MF, van der Windt GJW, Wiersinga WJ, Boukens BJD, Coumou J, Oei A, de Beer R, de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJTH, van der Poll T, The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi. PLOS PATHOG 2009;5 (5):e1000447 [PubMed]
Leendertse M, Heikens E, Wijnands LM, van Luit-Asbroek M, Teske GJD, Roelofs JJTH, Bonten MJM, van der Poll T, Willems RJL, Enterococcal surface protein transiently aggravates Enterococcus faecium-induced urinary tract infection in mice. J INFECT DIS 2009;200 (7):1162-1165 [PubMed]
Leendertse M, Willems RJL, Giebelen IAJ, Roelofs JJTH, Bonten MJM, van der Poll T, Neutrophils Are Essential for Rapid Clearance of Enterococcus faecium in Mice. INFECT IMMUN 2009;77 (1):485-491 [PubMed]
Leendertse M, Willems RJL, Giebelen IAJ, Roelofs JJTH, Top J, Bonten MJM, van der Poll T, Intestinal Colonization with Enterococcus faecium Does Not Influence Pulmonary Defense against Pseudomonas aeruginosa in Mice. PLOS ONE 2009;4 (8):e6775 [PubMed]
Leendertse M, Willems RJL, Giebelen IAJ, Roelofs JJTH, van Rooijen N, Bonten MJM, van der Poll T, Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice. INNATE IMMUN-LONDON 2009;15 (1):3-12 [PubMed]
Roelofs JJ, Florquin S. Tubulointerstitial Injury in IgA Nephropathy in: Lai KN, editors. Recent Advances in IgA Nephropathy. Hong Kong, China: World Scientific Publishing Co. Pte. Ltd.; 2009., p. 55-68
Roelofs JJTH, Rouschop KMA, Teske GJD, Wagenaar GTM, Claessen N, Weening JJ, van der Poll T, Florquin S, Endogenous tissue-type plasminogen activator is protective during ascending urinary tract infection. NEPHROL DIAL TRANSPL 2009;24 (3):801-808 [PubMed]
Roelofs JJTH, Teske GJD, Bonta PI, de Vries CJM, Meijers JCM, Weening JJ, van der Poll T, Florquin S, Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis. KIDNEY INT 2009;75 (1):52-59 [PubMed]
Wolthuis EK, Vlaar AP, Choi G, Roelofs JJTH, Juffermans NP, Schultz MJ, Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice. CRIT CARE 2009;13 (1):R1 [PubMed]
Wolthuis EK, Vlaar APJ, Choi G, Roelofs JJTH, Haitsma JJ, van der Poll T, Juffermans NP, Zweers MM, Schultz MJ, Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury. SHOCK 2009;31 (3):262-266 [PubMed]
Yapici U, Bemelman FJ, Scheepstra CG, Roelofs JJTH, Claessen N, van der Loos C, van Donselaar-van der Pant K, Bouts AHM, Idu MM, Rowshani AT, ten Berge IJM, Florquin S, Intragraft FOXP3 Protein or mRNA During Acute Renal Allograft Rejection Correlates With Inflammation, Fibrosis, and Poor Renal Outcome. TRANSPLANTATION 2009;87 (9):1377-1380 [PubMed]
Choi G, Hofstra JJH, Roelofs JJTH, Rijneveld AW, Bresser P, van der Zee JS, Florquin S, van der Poll T, Levi M, Schultz MJ, Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats. CRIT CARE MED 2008;36 (1):204-210 [PubMed]
Hovius JW, Schuijt TJ, de Groot KA, Roelofs JJTH, Oei GA, Marquart JA, de Beer R, van 't Veer C, van der Poll T, Ramamoorthi N, Fikrig E, van Dam AP, Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva. J INFECT DIS 2008;198 (8):1189-1197 [PubMed]
Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC, Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury. PLOS ONE 2008;3 (10):e3596 [PubMed]
Renckens R, Roelofs JJTH, Stegenga ME, Florquin S, Levi M, Carmeliet P, van't Veer C, van der Poll T, Transgenic tissue-type plasminogen activator expression improves host defense during Klebsiella pneumonia. J THROMB HAEMOST 2008;6 (4):660-668 [PubMed]
Renckens R, van Westerloo DJ, Roelofs JJTH, Pater JM, Schultz MJ, Florquin S, van der Poll T, Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice. CRIT CARE MED 2008;36 (2):580-587 [PubMed]
Roelofs JJ, Abramowicz D, Florquin S. Immunomodulators: interleukins, interferons, and IV immunoglobulin in: De Broe ME, Porter GA, Bennett WM, Deray G, editors. Clinical Nephrotoxins - Renal Injury from Drugs and Chemicals, Third Edition. S.l.: Springer; 2008., p. 683-698
Wiersinga WJ, de Vos AF, de Beer R, Wieland CW, Roelofs JJTH, Woods DE, van der Poll T, Inflammation patterns induced by different Burkholderia species in mice. CELL MICROBIOL 2008;10 (1):81-87 [PubMed]
Wiersinga WJ, de Vos AF, Wieland CW, Leendertse M, Roelofs JJTH, van der Poll T, CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice. J INFECT DIS 2008;198 (9):1388-1397 [PubMed]
Wiersinga WJ, Wieland CW, Roelofs JJTH, van der Poll T, MyD88 Dependent Signaling Contributes to Protective Host Defense against Burkholderia pseudomallei. PLOS ONE 2008;3 (10):e3494 [PubMed]
Choi G, Hofstra JJH, Roelofs JJTH, Florquin S, Bresser P, Levi M, van der Poll T, Schultz MJ, Recombinant human activated protein C inhibits local and systemic activation of coagulation without influencing inflammation during Pseudomonas aeruginosa pneumonia in rats. CRIT CARE MED 2007;35 (5):1362-1368 [PubMed]
Renckens R, Roelofs JJTH, Bonta PI, Florquin S, de Vries CJM, Levi M, Carmeliet P, van't Veer C, van der Poll T, Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia. BLOOD 2007;109 (4):1593-1601 [PubMed]
Roelofs JJTH. The fibrinolytic system in renal disease. s.l.: s.n.; 2007. 157p. ISBN 9789090219110 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Florquin S, Weening JJ; copromotor(s): )
Renckens R, Roelofs JJTH, Florquin S, de Vos AF, Lijnen HR, van't Veer C, van der Poll T, Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis. J IMMUNOL 2006;176 (6):3735-3741 [PubMed]
Renckens R, Roelofs JJTH, Florquin S, de Vos AF, Pater JM, Lijnen HR, Carmeliet P, van 't Veer C, van der Poll T, Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice. J IMMUNOL 2006;177 (2):1189-1196 [PubMed]
Renckens R, Roelofs JJTH, Florquin S, van der Poll T, Urokinase-type plasminogen activator receptor plays a role in neutrophil migration during lipopolysaccharide-induced peritoneal inflammation but not during Escherichia coli-induced peritonitis. J INFECT DIS 2006;193 (4):522-530 [PubMed]
Renckens R, Roelofs JJTH, Knapp S, de Vos AF, Florquin S, van der Poll T, The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia. J INFECT DIS 2006;193 (2):187-195 [PubMed]
Roelofs JJTH, Rouschop KMA, Leemans JC, Claessen N, de Boer AM, Frederiks WM, Lijnen HR, Weening JJ, Florquin S, Tissue-type plasminogen activator modulates inflammatory responses and renal function in ischemia reperfusion injury. J AM SOC NEPHROL 2006;17 (1):131-140 [PubMed]
Roelofs JJTH, Rouschop KMA, Teske GJD, Claessen N, Weening JJ, van der Poll T, Florquin S, The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis. KIDNEY INT 2006;70 (11):1942-1947 [PubMed]
Rouschop KMA, Roelofs JJTH, Sylva M, Rowshani AT, ten Berge IJM, Weening JJ, Florquin S, Renal expression of CD44 correlates with acute renal allograft rejection. KIDNEY INT 2006;70 (6):1127-1134 [PubMed]
Renckens R, Roelofs JJTH, de Waard V, Florquin S, Lijnen HR, Carmeliet P, van der Poll T, The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury. J THROMB HAEMOST 2005;3 (5):1018-1025 [PubMed]
Renckens R, Roelofs JJTH, ter Horst SAJ, van 't Veer C, Havik SR, Florquin S, Wagenaar GTM, Meijers JCM, van der Poll T, Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice. J IMMUNOL 2005;175 (10):6764-6771 [PubMed]
Rouschop KMA, Roelofs JJTH, Claessen N, da Costa Martins P, Zwaginga JJ, Pals ST, Weening JJ, Florquin S, Protection against renal ischemia reperfusion injury by CD44 disruption. J AM SOC NEPHROL 2005;16 (7):2034-2043 [PubMed]
Rouschop KMA, Roelofs JJTH, Rowshani AT, Leemans JC, van der Poll T, ten Berge IJM, Weening JJ, Florquin S, Pre-transplant plasma and cellular levels of CD44 correlate with acute renal allograft rejection. NEPHROL DIAL TRANSPL 2005;20 (10):2248-2254 [PubMed]
Rouschop KMA, Sewnath ME, Claessen N, Roelofs JJTH, Hoedemaeker I, van der Neut R, Aten J, Pals ST, Weening JJ, Florquin S, CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy. J AM SOC NEPHROL 2004;15 (3):674-686 [PubMed]
Roelofs JJTH, Rowshani AT, van den Berg JG, Claessen N, Aten J, ten Berge IJM, Weening JJ, Florquin S, Expression of urokinase plasminogen activator and its receptor during acute renal allograft rejection. KIDNEY INT 2003;64 (5):1845-1853 [PubMed]
Key publications

Jansen MPB, Emal D, Teske GJD, Dessing MC, Florquin S, Roelofs JJTH, Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps. KIDNEY INT 2017;91 (2):352-364 [PubMed]
Lattenist L, Ochodnický P, Ahdi M, Claessen N, Leemans JC, Satchell SC, Florquin S, Gerdes VE, Roelofs JJTH, Renal endothelial protein C receptor expression and shedding during diabetic nephropathy. J THROMB HAEMOST 2016;14 (6):1171-1182 [PubMed]
Lattenist L, Kers J, Claessen N, ten Berge IJM, Bemelman FJ, Florquin S, Roelofs JJTH, Renal and urinary levels of endothelial protein C receptor correlate with acute renal allograft rejection. PLOS ONE 2013;8 (5):e64994 [PubMed]
de Stoppelaar SF, van 't Veer C, Claushuis TAM, Albersen BJA, Roelofs JJTH, van der Poll T, Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice. BLOOD 2014;124 (25):3781-3790 [PubMed]
Lattenist L, Jansen MPB, Teske G, Claessen N, Meijers JCM, Rezaie AR, Esmon CT, Florquin S, Roelofs JJTH, Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties. THROMB HAEMOSTASIS 2016;116 (1):124-133 [PubMed]


All Publications

Curriculum Vitae

Joris Roelofs (1972) was educated at the Catholic University of Leuven (Belgium) and the VU University, Amsterdam, where he received his MD degree in 2000. He received his PhD degree from the Faculty of Medicine at the University of Amsterdam in 2007, and he was board certified in Pathology in 2008. Since then, Joris Roelofs has been a Consultant Histopathologist in the Department of Pathology at the AMC, specializing in kidney, liver and lung pathology. In 2010, he worked as a Research Fellow in the Kirkland Center for Lupus Research (Cornell University Medical College, New York City).

Research programmes

Coagulation and the kidney

My group studies reciprocal interactions between coagulation/hemostasis and mechanisms of renal disease. Currently, I focus on 2 distinct but complementary research lines:

1. The role of the Protein C and Protein S anticoagulant systems in acute kidney injury and renal transplant rejection

2. The role of blood platelets in acute and chronic renal disease, with an emphasis on diabetic nephropathy
 

Faculty
Dr. J.J.T.H. Roelofs MD PhD

PhD Students
Y.R. Bouatou
Drs. M.P.B. Jansen
M. Uil

Prof. dr. S. Florquin (Renal inflammation and repair)

Other research related activities
  • Contribution to training of professionals, www.renalpathologycourse.org
  • Contribution to training of professionals, Educational Ambassador, International Society of Nephrology
  • Membership of medical or scientific committee, Renal Pathology Society, Research Committee
  • Membership of medical or scientific committee, Stichting PALGA, Wetenschappelijke Raad
  • Membership of medical or scientific committee, ZonMw (Netherlands Organisation for Health Research and Development), Off Road commissie
  • Membership of editorial board / Editorship, ISRN VASCULAR MEDICINE
  • Membership of editorial board / Editorship, World Journal of Nephrology
  • Membership of editorial board / Editorship, World Journal of Translational Medicine
Current research funding
  • AMC
  • ZonMw