• Principal Investigator
  • Male

Dr. L. Vermeulen MD PhD

Position: Other
Main activities: Patient care, Research
Specialisation: Cancer research
foto L. Vermeulen is one of the AMC Principal Investigators
Focus of research:
  • Cancer stem cells
  • Colorectal cancer
  • Cancer subtypes
  • Tumor evolution
AMC themes: Metabolic disorders and gastrointestinal diseases, Oncology
Departments: Center of Experimental and Molecular Medicine
Bijlsma MF, Sadanandam A, Tan P, Vermeulen L, Molecular subtypes in cancers of the gastrointestinal tract. NAT REV GASTRO HEPAT 2017;14 (6):333-342 [PubMed]
Dienstmann R, Vermeulen L, Guinney J, Kopetz S, Tejpar S, Tabernero J, Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. NAT REV CANCER 2017;17 (2):79-92 [PubMed]
Ebbing EA, Steins A, Fessler E, Stathi P, Lesterhuis WJ, Krishnadath KK, Vermeulen L, Medema JP, Bijlsma MF, van Laarhoven HWM, Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition. GASTROENTEROLOGY 2017;ahead of print [PubMed]
Punt CJA, Koopman M, Vermeulen L, From tumour heterogeneity to advances in precision treatment of colorectal cancer. NAT REV CLIN ONCOL 2017;14 (4):235-246 [PubMed]
Than BLN, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Walter J, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJA, Meijer GA, van den Broek E, Hodges CA, Scott PM, Vermeulen L, Cormier RT, CFTR is a tumor suppressor gene in murine and human intestinal cancer. ONCOGENE 2017;36 (24):3504 [PubMed]
Trinh A, Trumpi K, de Sousa E Melo F, Wang X, de Jong JH, Fessler E, Kuppen PJK, Reimers MS, Swets M, Koopman M, Nagtegaal ID, Jansen M, Hooijer GKJ, Offerhaus GJA, Kranenburg O, Punt CJ, Medema JP, Markowetz F, Vermeulen L, Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry. CLIN CANCER RES 2017;23 (2):387-398 [PubMed]
van Neerven SM, Vermeulen L, Balancing signals in the intestinal niche. EMBO J 2017;36 (4):389-391 [PubMed]
den Uil SH, Coupé VMH, Linnekamp JF, van den Broek E, Goos JACM, Delis-van Diemen PM, Belt EJT, van Grieken NCT, Scott PM, Vermeulen L, Medema JP, Bril H, Stockmann HBAC, Cormier RT, Meijer GA, Fijneman RJA, Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence. BRIT J CANCER 2016;115 (12):1565-1574 [PubMed]
de Sousa E Melo F, Vermeulen L, Wnt Signaling in Cancer Stem Cell Biology. CANCERS (BASEL) 2016;8 (7):60 [PubMed]
Domingo E, Freeman-Mills L, Rayner E, Glaire M, Briggs S, Vermeulen L, Fessler E, Medema JP, Boot A, Morreau H, van Wezel T, Liefers GJ, Lothe RA, Danielsen SA, Sveen A, Nesbakken A, Zlobec I, Lugli A, Koelzer VH, Berger MD, Castellví-Bel S, Muñoz J, de Bruyn M, Nijman HW, Novelli M, Lawson K, Oukrif D, Frangou E, Dutton P, Tejpar S, Delorenzi M, Kerr R, Kerr D, Tomlinson I, Church DN, Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study. LANCET GASTROENTEROL HEPATOL 2016;1 (3):207-216 [PubMed]
Fessler E. Exploring tumor heterogeneity. S.l.: s.n.; 2016. 196p. ISBN 978-94-6295-379-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Vermeulen L)
Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, de Sousa E Melo F, Prasetyanti PR, IJspeert JEG, Franitza M, Nürnberg P, van Noesel CJM, Dekker E, Vermeulen L, Clevers H, Medema JP, TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO MOL MED 2016;8 (7):745-760 [PubMed]
Fessler E, Jansen M, de Sousa E Melo F, Zhao L, Prasetyanti PR, Rodermond H, Kandimalla R, Linnekamp JF, Franitza M, van Hooff SR, de Jong JH, Oppeneer SC, van Noesel CJM, Dekker E, Stassi G, Wang X, Medema JP, Vermeulen L, A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype. ONCOGENE 2016;35 (46):6026-6037 [PubMed]
Habeeb NWA, Kulasingam V, Diamandis EP, Yousef GM, Tsongalis GJ, Vermeulen L, Zhu Z, Kamel-Reid S, The Use of Targeted Therapies for Precision Medicine in Oncology. CLIN CHEM 2016;62 (12):1556-1564 [PubMed]
Lenos KJ, Vermeulen L, Cancer stem cells don't waste their time cleaning-low proteasome activity, a marker for cancer stem cell function. ANN TRANSL MED 2016;4 (24):519 [PubMed]
Léveillé N, Vermeulen L, Polycomb complex PRC1 as gatekeeper of intestinal stem cell identity. STEM CELL INVESTIG 2016;3:22 [PubMed]
Than BLN, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJA, Meijer GA, van den Broek E, Hodges CA, Scott PM, Vermeulen L, Cormier RT, CFTR is a tumor suppressor gene in murine and human intestinal cancer. ONCOGENE 2016;35 (32):4191-4199 [PubMed]
van der Heijden M, Winton DJ, Vermeulen L, Turning off the BCL-2 switch to prevent intestinal tumorigenesis. ONCOTARGET 2016;7 (20):28763-28764 [PubMed]
van der Heijden M, Zimberlin CD, Nicholson AM, Colak S, Kemp R, Meijer SL, Medema JP, Greten FR, Jansen M, Winton DJ, Vermeulen L, Bcl-2 is a critical mediator of intestinal transformation. NAT COMMUN 2016;7:10916 [PubMed]
van Neerven SM, Tieken M, Vermeulen L, Bijlsma MF, Bidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneity. MOL CELL ONCOL 2016;3 (2):e1098791 [PubMed]
Vellinga TT, den Uil S, Rinkes IHB, Marvin D, Ponsioen B, Alvarez-Varela A, Fatrai S, Scheele C, Zwijnenburg DA, Snippert H, Vermeulen L, Medema JP, Stockmann HB, Koster J, Fijneman RJA, de Rooij J, Kranenburg O, Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion. ONCOGENE 2016;35 (40):5263-5271 [PubMed]
Zimberlin CD. Crossing Borders: Manipulating stemness through carcinogenesis. S.l.: s.n.; 2016. 221p. ISBN 978-94-6182-676-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Vermeulen L, Bots M)
Casey SC, Vaccari M, Al-Mulla F, Al-Temaimi R, Amedei A, Barcellos-Hoff MH, Brown DG, Chapellier M, Christopher J, Curran CS, Forte S, Hamid RA, Heneberg P, Koch DC, Krishnakumar PK, Laconi E, Maguer-Satta V, Marongiu F, Memeo L, Mondello C, Raju J, Roman J, Roy R, Ryan EP, Ryeom S, Salem HK, Scovassi AI, Singh N, Soucek L, Vermeulen L, Whitfield JR, Woodrick J, Colacci A, Bisson WH, Felsher DW, The effect of environmental chemicals on the tumor microenvironment. CARCINOGENESIS 2015;36 (Suppl. 1):S160-S183 [PubMed]
Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondráček J, Raju J, Roman J, Wise JP Sr, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SAS, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z, Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. CARCINOGENESIS 2015;36 (Suppl. 1):S254-S296 [PubMed]
Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, de Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S, The consensus molecular subtypes of colorectal cancer. NAT MED 2015;21 (11):1350-1356 [PubMed]
IJspeert JEG, Vermeulen L, Meijer GA, Dekker E, Serrated neoplasia-role in colorectal carcinogenesis and clinical implications. NAT REV GASTRO HEPAT 2015;12 (7):401-409 [PubMed]
Linnekamp JF, Wang X, Medema JP, Vermeulen L, Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes. CANCER RES 2015;75 (2):245-249 [PubMed]
Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR, ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. CELL REP 2015;13 (3):490-494 [PubMed]
Morrissey ER, Vermeulen L, Stem cell competition: how speeding mutants beat the rest. EMBO J 2014;33 (20):2277-2278 [PubMed]
Sadanandam A, Wang X, de Sousa E Melo F, Gray JW, Vermeulen L, Hanahan D, Medema JP, Reconciliation of classification systems defining molecular subtypes of colorectal cancer: interrelationships and clinical implications. CELL CYCLE 2014;13 (3):353-357 [PubMed]
Vermeulen L, Snippert HJ, Stem cell dynamics in homeostasis and cancer of the intestine. NAT REV CANCER 2014;14 (7):468-480 [PubMed]
Buczacki SJA, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ, Intestinal label-retaining cells are secretory precursors expressing Lgr5. NATURE 2013;495 (7439):65-69 [PubMed]
de Sousa E Melo F. Colon cancer heterogeneity: stem cells, signals and subtypes. s.l.: s.n.; 2013. 203p. ISBN 98789461823267 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Vermeulen L)
de Sousa E Melo F, Vermeulen L, Fessler E, Medema JP, Cancer heterogeneity--a multifaceted view. EMBO REP 2013;14 (8):686-695 [PubMed]
de Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LPMH, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJM, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L, Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. NAT MED 2013;19 (5):614-618 [PubMed]
Kozar S, Morrissey E, Nicholson AM, van der Heijden M, Zecchini HI, Kemp R, Tavaré S, Vermeulen L, Winton DJ, Continuous Clonal Labeling Reveals Small Numbers of Functional Stem Cells in Intestinal Crypts and Adenomas. CELL STEM CELL 2013;13 (5):626-633 [PubMed]
Prasetyanti PR, Zimberlin CD, Bots M, Vermeulen L, Melo FDSE, Medema JP, Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon. MOL CANCER 2013;12 (1):126 [PubMed]
Vermeulen L, Keeping Stem Cells in Check: A Hippo Balancing Act. CELL STEM CELL 2013;12 (1):3-5 [PubMed]
Vermeulen L, Medema JP. De pathogenese van dikkedarmkanker in: Punt CJA, Marijnen CAM, Nagtegaal ID, van de Velde CJH, editors. Handboek colorectaal carcinoom. Utrecht: De Tijdstroom; 2013., p. 37-46
Vermeulen L, Morrissey E, van der Heijden M, Nicholson AM, Sottoriva A, Buczacki S, Kemp R, Tavaré S, Winton DJ, Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation. SCIENCE 2013;342 (6161):995-998 [PubMed]
Wang X, Markowetz F, de Sousa E Melo F, Medema JP, Vermeulen L, Dissecting cancer heterogeneity--an unsupervised classification approach. INT J BIOCHEM CELL B 2013;45 (11):2574-2579 [PubMed]
Zeilstra J, Joosten SPJ, Vermeulen L, Koster J, Medema JP, Versteeg R, Spaargaren M, Pals ST, CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status. PLOS ONE 2013;8 (8):e72849 [PubMed]
de Jong JH, Rodermond HM, Zimberlin CD, Lascano V, de Sousa E Melo F, Richel DJ, Medema JP, Vermeulen L, Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis. SCI REP-UK 2012;2:271 [PubMed]
Kemper K, Versloot M, Cameron K, Colak S, de Sousa E Melo F, de Jong JH, Bleackley J, Vermeulen L, Versteeg R, Koster J, Medema JP, Mutations in the Ras-Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer. CLIN CANCER RES 2012;18 (11):3132-3141 [PubMed]
Vermeulen L, de Sousa E Melo F, Richel DJ, Medema JP, The developing cancer stem-cell model: clinical challenges and opportunities. LANCET ONCOL 2012;13 (2):E83-E89 [PubMed]
Borovski T, de Sousa E Melo F, Vermeulen L, Medema JP, Cancer Stem Cell Niche: The Place to Be. CANCER RES 2011;71 (3):634-639 [PubMed]
de Sousa E Melo F, Colak S, Buikhuisen J, Koster J, Cameron K, de Jong JH, Tuynman JB, Prasetyanti PR, Fessler E, van den Bergh SP, Rodermond H, Dekker E, van der Loos CM, Pals ST, van de Vijver MJ, Versteeg R, Richel DJ, Vermeulen L, Medema JP, Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. CELL STEM CELL 2011;9 (5):476-485 [PubMed]
de Sousa E Melo F, Guessous I, Vermeulen L, Medema JP, Cellules souches cancéreuses et futures modalités thérapeutiques du cancer. REV MED SUISSE 2011;7 (289):774-777 [PubMed]
de Sousa E Melo F, Vermeulen L, Richel D, Medema JP, Targeting Wnt Signaling in Colon Cancer Stem Cells. CLIN CANCER RES 2011;17 (4):647-653 [PubMed]
Medema JP, Vermeulen L, Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. NATURE 2011;474 (7351):318-326 [PubMed]
Sottoriva A, Vermeulen L, Tavaré S, Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors. PLOS COMPUT BIOL 2011;7 (5):e1001132 [PubMed]
Kemper K, Sprick MR, de Bree M, Scopelliti A, Vermeulen L, Hoek M, Zeilstra J, Pals ST, Mehmet H, Stassi G, Medema JP, The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation. CANCER RES 2010;70 (2):719-729 [PubMed]
Sottoriva A, Sloot PMA, Medema JP, Vermeulen L, Exploring cancer stem cell niche directed tumor growth. CELL CYCLE 2010;9 (8):1472-1479 [PubMed]
Sottoriva A, Verhoeff JJC, Borovski T, McWeeney SK, Naumov L, Medema JP, Sloot PMA, Vermeulen L, Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity. CANCER RES 2010;70 (1):46-56 [PubMed]
Vermeulen L. Cancer stem cells - a numbers game?. s.l.: s.n.; 2010. 224p. ISBN 9789090257105 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP, Richel DJ; copromotor(s): )
Vermeulen L, de Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP, Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. NAT CELL BIOL 2010;12 (5):468-U121 [PubMed]
Borovski T, Vermeulen L, Sprick MR , Medema JP, One renegade cancer stem cell?. CELL CYCLE 2009;8 (6):803-808 [PubMed]
Vermeulen L, Medema JP, Hardwick JCH, van den Brink GR. Cancer Stem Cells in Colorectal Cancer in: Majumder S, editor. Stem Cells and Cancer. Berlin; New York: Springer; 2009., p. 233-250
Vermeulen L, Verhoeff JJC, Richel DJ, Medema JP, Kankerstamcellen. NED TIJDSCHR GENEESKD 2009;153 (7):286-290 [PubMed]
Tuynman JB, Vermeulen L, Boon EM, Kemper K, Zwinderman AH, Peppelenbosch MP, Richel DJ, Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. CANCER RES 2008;68 (4):1213-1220 [PubMed]
Vermeulen L, Sprick MR , Kemper K, Stassi G, Medema JP, Cancer stem cells--old concepts, new insights. CELL DEATH DIFFER 2008;15 (6):947-958 [PubMed]
Vermeulen L, Todaro M, de Sousa E Melo F, Sprick MR , Kemper K, Alea MP, Richel DJ, Stassi G, Medema JP, Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. P NATL ACAD SCI USA 2008;105 (36):13427-13432 [PubMed]
Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, Iovino F, Tripodo C, Russo A, Gulotta G, Medema JP, Stassi G, Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. CELL STEM CELL 2007;1 (4):389-402 [PubMed]
Löwenberg M, Tuynman J, Scheffer M, Verhaar A, Vermeulen L, van Deventer S, Hommes D, Peppelenbosch M, Kinome analysis reveals nongenomic glucocorticoid receptor-dependent inhibition of insulin signaling. ENDOCRINOLOGY 2006;147 (7):3555-3562 [PubMed]
Key publications

de Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LPMH, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJM, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L, Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. NAT MED 2013;19 (5):614-618 [PubMed]
Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, de Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S, The consensus molecular subtypes of colorectal cancer. NAT MED 2015;21 (11):1350-1356 [PubMed]
Vermeulen L, Morrissey E, van der Heijden M, Nicholson AM, Sottoriva A, Buczacki S, Kemp R, Tavaré S, Winton DJ, Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation. SCIENCE 2013;342 (6161):995-998 [PubMed]
Medema JP, Vermeulen L, Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. NATURE 2011;474 (7351):318-326 [PubMed]
Punt CJA, Koopman M, Vermeulen L, From tumour heterogeneity to advances in precision treatment of colorectal cancer. NAT REV CLIN ONCOL 2017;14 (4):235-246 [PubMed]


All Publications

Curriculum Vitae

Academic experience
2013 - present Principal Investigator at the Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam.

2011-2013 Research Fellow at the Cancer Research UK – Cambridge Institute, University of Cambridge, Cambridge, UK. 

2011-2013 Fellow of Wolfson College, Cambridge University.

2010-2012 Post-doc at the Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam.

2006-2010 PhD student in Experimental oncology. Academic Medical Center, Amsterdam.

Education
2012 MD degree (cum laude), Academic Medical Center, University of Amsterdam.

2010 PhD degree (cum laude), Academic Medical Center, University of Amsterdam. Thesis: “Cancer Stem Cells – a numbers game?”.

Awards, honours, prizes, career development grants etc.
- European Research Council (ERC) Starting Grant , 2014
- Maag Lever Darm Stichting (MLDS) Career Development Grant, 2014
- MD degree, cum laude, 2012
- Junior Research Fellowship, Wolfson College, Cambridge, UK, 2011
- Dutch Cancer Society Fellowship/KWF Fellowship, 2011
- AMC Graduate School – Excellent Thesis Award 2010
- PhD degree, cum laude, 2010
- AMC Graduate School – Young Scientist Publication Award 2008, 1st prize
 

Research programmes

Molecular Oncology

Louis Vermeulen MD PhD is a group leader/principal investigator within the Center for Experimental Molecular Medicine (CEMM), Laboratory for Experimental Oncology and Radiobiology (LEXOR) at the Academic Medical Center (AMC), Amsterdam. Louis Vermeulen studied medicine and obtained his PhD at the AMC, and afterwards worked as a research fellow at the University of Cambridge, UK. His group uses quantitative approaches in combination with state of the art in vitro and in vivo models to study the biology of intestinal cancers in order to improve tumor classification and therapies.

In particular his research focuses on:
1. Stem cell dynamics in developing and established cancers
Stem cells are essential for the homeostasis of most adult human tissues. Previously we identified stem-like cells that fuel the growth and progression of cancers. We elucidated how oncogenic mutations alter the population dynamics during tumorigenesis. In addition we defined microenvironmental factors that regulate stem cell function in cancers. We have now developed marker free tracing approaches to study the functional behavior of stem-like cells in both pre-neoplastic lesions and human cancer tissue. We use these tools to improve chemopreventive strategies and to develop novel, and more effective therapies.

2. Molecular cancer subtypes
Colorectal cancer is a highly heterogeneous disease. Intriguingly, the genetic features of cancers only explain part of this. Recently we have developed gene expression based classifications that identify colorectal cancer subtypes with radically different molecular features and clinical properties, including their response to commonly used targeted agents. We now develop improved and clinically applicable classification assays, aim to elucidate the molecular drivers of the unique properties of each subtype, and evaluate subtype-specific therapeutic interventions.

Louis Vermeulen is supported by several personal grants, including an ERC starting grant, a VIDI grant from the Dutch Science Organization (NOW/ZonMw), and a career development grant of the Dutch Digestive Foundation (MLDS).

 

Faculty
Dr. L. Vermeulen MD PhD

Postdocs
Dr. K. Lenos
Dr. N. Léveillé
Dr. D.V. Miedema
Dr. S. Simmini

PhD Students
R.S.M. Adam
P.J. Asif
Drs. J.Y. Buikhuisen
Drs. M.C.S van der Heijden
S. ten Hoorn
S.C. Lodestijn
S.M. van Neerven MSc
Drs. J.F. Linnekamp MD

Others
M.C. Lecca
Ing. L.E. Nijman
Ing. A. van Oort

Prof. dr. J.P. Medema (Cell death induction and resistance in tumor cells)

Prof. dr. C.J.A. Punt MD PhD (Clinical and translational research in gastrointestinal cancer, with focus on colorectal cancer)

Other research related activities
  • None reported
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Assosiation for International Cancer Research
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • Europese Unie
  • KWF Kankerbestrijding
  • Maag, Lever, Darm Stichting
  • Maurits en Anna de Kock Stichting
  • ZonMw