• Principal Investigator
  • Male

Dr. J. den Dunnen PhD

Position: Scientific staff member (UD)
Main activities: Research
Specialisation: Immunology
foto J. den Dunnen is one of the AMC Principal Investigators
Focus of research:

Investigating the role of Fc receptors on myeloid cells during bacterial infections, rheumatoid arthritis, and inflammatory bowel disease.

AMC themes: Infection & Immunity, Metabolic disorders and gastrointestinal diseases
Departments: Experimental Immunology, Internal Medicine: Clinical Immunology and Rheumatology
Hansen IS, Hoepel W, Zaat SAJ, Baeten DLP , den Dunnen J, Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI-TLR Cross-Talk. J IMMUNOL 2017;ahead of print [PubMed]
Vogelpoel LTC. FcγRIIa, a novel director of cytokine production in infection and autoimmunity. S.l.: s.n.; 2015. 176p. ISBN 978-94-6233-077-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de Jong EC, Kapsenberg ML; copromotor(s): den Dunnen J)
Vogelpoel LTC, Baeten DLP , de Jong EC, den Dunnen J, Control of cytokine production by human Fc gamma receptors: implications for pathogen defense and autoimmunity. FRONT IMMUNOL 2015;6:79 [PubMed]
Vogelpoel LTC, Hansen IS, Visser MW, Nagelkerke SQ, Kuijpers TW, Kapsenberg ML, de Jong EC, den Dunnen J, FcγRIIa cross-talk with TLRs, IL-1R, and IFNγR selectively modulates cytokine production in human myeloid cells. IMMUNOBIOLOGY 2015;220 (2):193-199 [PubMed]
Vogelpoel LTC, Hansen IS, Rispens T, Muller FJM, van Capel TMM, Turina MC, Vos JB, Baeten DLP , Kapsenberg ML, de Jong EC, den Dunnen J, Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages. NAT COMMUN 2014;5:5444 [PubMed]
den Dunnen J, Vogelpoel LTC, Wypych T, Muller FJM, de Boer L, Kuijpers TW, Zaat SAJ, Kapsenberg ML, de Jong EC, IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and Fc gamma RIIa in human dendritic cells. BLOOD 2012;120 (1):112-121 [PubMed]
den Dunnen J, Gringhuis SI, Geijtenbeek TBH, Dusting the sugar fingerprint: C-type lectin signaling in adaptive immunity. IMMUNOL LETT 2010;128 (1):12-16 [PubMed]
Gringhuis SI, van der Vlist M, van den Berg LM, den Dunnen J, Litjens M, Geijtenbeek TBH, HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. NAT IMMUNOL 2010;11 (5):419-U81 [PubMed]
den Dunnen J. C-type lectin signaling in response to pathogens. S.l.: s.n.; 2009. 194p. ISBN 978 90 8570 286 3 Proefschrift Vrije Universiteit Amsterdam, MCBI. (Promotor(s): van Kooyk Y; copromotor(s): Geijtenbeek TBH, Gringhuis SI)
den Dunnen J, Gringhuis SI, Geijtenbeek TBH, Innate signaling by the C-type lectin DC-SIGN dictates immune responses. CANCER IMMUNOL IMMUN 2009;58 (7):1149-1157 [PubMed]
de Witte L, de Jong MAWP, den Dunnen J, van Kooyk Y, Geijtenbeek TBH, Identification of pathogen receptors on dendritic cells to understand their function and to identify new drug targets. METHODS MOL BIOL 2009;531:267-285 [PubMed]
Geijtenbeek TBH, den Dunnen J, Gringhuis SI, Pathogen recognition by DC-SIGN shapes adaptive immunity. FUTURE MICROBIOL 2009;4 (7):879-890 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TBH, Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. NAT IMMUNOL 2009;10 (10):1081-U58 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SCM, Geijtenbeek TBH, Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. NAT IMMUNOL 2009;10 (2):203-213 [PubMed]
Appelmelk BJ, den Dunnen J, Driessen NN, Ummels R, Pak M, Nigou J, Larrouy-Maumus G, Gurcha SS, Movahedzadeh F, Geurtsen J, Brown EJ, Eysink Smeets MM, Besra GS, Willemsen PTJ, Lowary TL, van Kooyk Y, Maaskant JJ, Stoker NG, van der Ley P, Puzo G, Vandenbroucke-Grauls CMJE, Wieland CW, van der Poll T, Geijtenbeek TBH, van der Sar AM, Bitter W, The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction. CELL MICROBIOL 2008;10 (4):930-944 [PubMed]
Hovius JWR, de Jong MAWP, den Dunnen J, Litjens M, Fikrig E, van der Poll T, Gringhuis SI, Geijtenbeek TBH, Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLOS PATHOG 2008;4 (2):e31 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van het Hof B, van Kooyk Y, Geijtenbeek TBH, C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. IMMUNITY 2007;26 (5):605-616 [PubMed]
van Vliet SJ, den Dunnen J, Gringhuis SI, Geijtenbeek TB, van Kooyk Y, Innate signaling and regulation of Dendritic cell immunity. CURR OPIN IMMUNOL 2007;19 (4):435-440 [PubMed]
Wieland CW, Koppel EA, den Dunnen J, Florquin S, McKenzie ANJ, van Kooyk Y, van der Poll T, Geijtenbeek TBH, Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis. MICROBES INFECT 2007;9 (2):134-141 [PubMed]
Key publications

Vogelpoel LTC, Baeten DLP , de Jong EC, den Dunnen J, Control of cytokine production by human Fc gamma receptors: implications for pathogen defense and autoimmunity. FRONT IMMUNOL 2015;6:79 [PubMed]
Vogelpoel LTC, Hansen IS, Rispens T, Muller FJM, van Capel TMM, Turina MC, Vos JB, Baeten DLP , Kapsenberg ML, de Jong EC, den Dunnen J, Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages. NAT COMMUN 2014;5:5444 [PubMed]
den Dunnen J, Vogelpoel LTC, Wypych T, Muller FJM, de Boer L, Kuijpers TW, Zaat SAJ, Kapsenberg ML, de Jong EC, IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and Fc gamma RIIa in human dendritic cells. BLOOD 2012;120 (1):112-121 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SCM, Geijtenbeek TBH, Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. NAT IMMUNOL 2009;10 (2):203-213 [PubMed]
Gringhuis SI, den Dunnen J, Litjens M, van het Hof B, van Kooyk Y, Geijtenbeek TBH, C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. IMMUNITY 2007;26 (5):605-616 [PubMed]


All Publications

Research programmes

Fc receptor induced inflammation

Faculty
Dr. J. den Dunnen PhD

PhD Students
I.S. Hansen
J.W. Hoepel MSc
M. Newling

Prof. dr. D.L.P. Baeten (Immunopathology of chronic inflammatory arthritis)

Other research related activities
  • None reported
Current research funding
  • AMC (Vrijgesteld)
  • Maag, Lever, Darm Stichting
  • Reumafonds