• Principal Investigator
  • Female

Dr. ir. M. Siebes PhD

Position: Associate professor (UHD)
Main activities: Research, Teaching
Specialisation: Cardiovascular Hemodynamics and Perfusion
foto M. Siebes is one of the AMC Principal Investigators
Focus of research:
  • Mechanics of coronary perfusion
  • Cardiac-coronary interaction
  • Coronary microvascular dysfunction
  • Structural and functional adaptation of vascular networks
  • 3D imaging of vascular networks and fluorescent biomarkers
AMC themes: Cardiovascular Diseases
Departments: Biomedical Engineering and Physics
Bedussi B, van der Wel NN, de Vos J, van Veen H, Siebes M, VanBavel E, Bakker EN, Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways. J CEREBR BLOOD F MET 2017;37 (4):1374-1385 [PubMed]
Casadonte L, Marques KM, Spaan JAE, Siebes M, Temporal dissociation between the minimal distal-to-aortic pressure ratio and peak hyperemia during intravenous adenosine infusion. AM J PHYSIOL-HEART C 2017;312 (5):H992-H1001 [PubMed]
Hakimzadeh N. Cellular and molecular players in vascular and left ventricular remodeling. S.l.: s.n.; 2017. 233p. ISBN 978-94-6295-559-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Piek JJ; copromotor(s): Siebes M, Verberne HJ)
Schwarz JCV, van Lier MGJTB, Bakker ENTP, de Vos J, Spaan JAE, VanBavel E, Siebes M, Optimization of Vascular Casting for Three-Dimensional Fluorescence Cryo-Imaging of Collateral Vessels in the Ischemic Rat Hindlimb. MICROSC MICROANAL 2017;23 (1):77-87 [PubMed]
Hakimzadeh N, van Lier MGJTB, van Horssen P, Daal M, Ly DH, Belterman C, Coronel R, Spaan JAE, Siebes M, Selective subepicardial localization of monocyte subsets in response to progressive coronary artery constriction. AM J PHYSIOL-HEART C 2016;311 (1):H239-H250 [PubMed]
Lumley M, Williams R, Asrress KN, Arri S, Briceno N, Ellis H, Rajani R, Siebes M, Piek JJ, Clapp B, Redwood SR, Marber MS, Chambers JB, Perera D, Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis. J AM COLL CARDIOL 2016;68 (7):688-697 [PubMed]
Rivolo S, Hadjilucas L, Sinclair M, van Horssen P, van den Wijngaard J, Wesolowski R, Chiribiri A, Siebes M, Smith NP, Lee J, Impact of coronary bifurcation morphology on wave propagation. AM J PHYSIOL-HEART C 2016;311 (4):H855-H870 [PubMed]
Rolandi MC, Wiegerinck EMA, Casadonte L, Yong ZY, Koch KT, Vis M, Piek JJ, Baan J Jr, Spaan JAE, Siebes M, Transcatheter Replacement of Stenotic Aortic Valve Normalizes Cardiac-Coronary Interaction by Restoration of Systolic Coronary Flow Dynamics as Assessed by Wave Intensity Analysis. CIRC-CARDIOVASC INTE 2016;9 (4):e002356 [PubMed]
Schrauwen JTC, Schwarz JCV, Wentzel JJ, van der Steen AFW, Siebes M, Gijsen FJH, The impact of scaled boundary conditions on wall shear stress computations in atherosclerotic human coronary bifurcations. AM J PHYSIOL-HEART C 2016;310 (10):H1304-H1312 [PubMed]
van de Hoef TP , Petraco R, van Lavieren MA, Nijjer S, Nolte F, Sen S, Echavarria-Pinto M, Henriques JPS, Koch KT, Baan J Jr, de Winter RJ, Siebes M, Spaan JAE, Tijssen JGP, Meuwissen M, Escaned J, Davies JE, Piek JJ, Basal stenosis resistance index derived from simultaneous pressure and flow velocity measurements. EUROINTERVENTION 2016;12 (2):e199-e207 [PubMed]
van Horssen P, van Lier MGJTB, van den Wijngaard JPHM, VanBavel E, Hoefer IE, Spaan JAE, Siebes M, Influence of segmented vessel size due to limited imaging resolution on coronary hyperemic flow prediction from arterial crown volume. AM J PHYSIOL-HEART C 2016;310 (7):H839-H846 [PubMed]
van Lier MGJTB, Lopriore E, Vandenbussche FPHA, Streekstra GJ, Siebes M, Nikkels PGJ, Oepkes D, van Gemert MJC, van den Wijngaard JPHM, Acardiac twinning: High resolution three-dimensional reconstruction of a low resistance case. BIRTH DEFECTS RES A 2016;106 (3):213-217 [PubMed]
van Lier MGJTB, Oost E, Spaan JAE, van Horssen P, van der Wal AC, VanBavel E, Siebes M, van den Wijngaard JPHM, Transmural distribution and connectivity of coronary collaterals within the human heart. CARDIOVASC PATHOL 2016;25 (5):405-412 [PubMed]
Bedussi B, van Lier MGJTB, Bartstra JW, de Vos J, Siebes M, VanBavel E, Bakker ENTP, Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system. FLUIDS BARRIERS CNS 2015;12 (1):23 [PubMed]
Schuster A, Sinclair M, Zarinabad N, Ishida M, van den Wijngaard JPHM, Paul M, van Horssen P, Hussain ST, Perera D, Schaeffter T, Spaan JAE, Siebes M, Nagel E, Chiribiri A, A quantitative high resolution voxel-wise assessment of myocardial blood flow from contrast-enhanced first-pass magnetic resonance perfusion imaging: microsphere validation in a magnetic resonance compatible free beating explanted pig heart model. EUR HEART J-CARD IMG 2015;16 (10):1082-1092 [PubMed]
Sinclair M, Lee J, Schuster A, Chiribiri A, van den Wijngaard J, van Horssen P, Siebes M, Spaan JAE, Nagel E, Smith NP, Microsphere skimming in the porcine coronary arteries: Implications for flow quantification. MICROVASC RES 2015;100:59-70 [PubMed]
van de Hoef TP. Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements. S.l.: s.n.; 2015. 359p. ISBN 978-94-6169-681-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Piek JJ, Spaan JAE; copromotor(s): Tijssen JGP, Meuwissen M, Siebes M)
van de Hoef TP , Meuwissen M, Escaned J, Sen S, Petraco R, van Lavieren MA, Echavarria-Pinto M, Nolte F, Nijjer S, Chamuleau SAJ, Voskuil M, van Eck-Smit BLF, Verberne HJ, Henriques JPS, Koch KT, de Winter RJ, Spaan JAE, Siebes M, Tijssen JGP, Davies JE, Piek JJ, Head-to-head comparison of basal stenosis resistance index, instantaneous wave-free ratio, and fractional flow reserve: diagnostic accuracy for stenosis-specific myocardial ischaemia. EUROINTERVENTION 2015;11 (8):914-925 [PubMed]
van de Hoef TP , Siebes M, Spaan JAE, Piek JJ, Fundamentals in clinical coronary physiology: why coronary flow is more important than coronary pressure. EUR HEART J 2015;36 (47):3312-339a [PubMed]
Xie B, Stammes MA, van Driel PBAA, Cruz LJ, Knol-Blankevoort VT, Löwik MAM, Mezzanotte L, Que I, Chan A, van den Wijngaard JPHM, Siebes M, Gottschalk S, Razansky D, Ntziachristos V, Keereweer S, Horobin RW, Hoehn M, Kaijzel EL, van Beek ER, Snoeks TJA, Löwik CWGM, Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models. ONCOTARGET 2015;6 (36):39036-39049 [PubMed]
Hakimzadeh N, van Horssen P, van Lier MGJTB, van den Wijngaard JPHM, Belterman C, Coronel R, Piek JJ, Verberne HJ, Spaan JAE, Siebes M, Detection and quantification methods of monocyte homing in coronary vasculature with an imaging cryomicrotome. J MOL CELL CARDIOL 2014;76:196-204 [PubMed]
Hakimzadeh N, Verberne HJ, Siebes M, Piek JJ, The future of collateral artery research. CURR CARDIOL REV 2014;10 (1):73-86 [PubMed]
Hyde ER, Cookson AN, Lee J, Michler C, Goyal A, Sochi T, Chabiniok R, Sinclair M, Nordsletten DA, Spaan J, van den Wijngaard JPHM, Siebes M, Smith NP, Multi-scale parameterisation of a myocardial perfusion model using whole-organ arterial networks. ANN BIOMED ENG 2014;42 (4):797-811 [PubMed]
Jeremias A, Maehara A, Généreux P, Asrress KN, Berry C, de Bruyne B, Davies JE, Escaned J, Fearon WF, Gould KL, Johnson NP, Kirtane AJ, Koo BK, Marques KM, Nijjer S, Oldroyd KG, Petraco R, Piek JJ, Pijls NH, Redwood S, Siebes M, Spaan JAE, van 't Veer M, Mintz GS, Stone GW, Multicenter core laboratory comparison of the instantaneous wave-free ratio and resting Pd/Pa with fractional flow reserve: the RESOLVE study. J AM COLL CARDIOL 2014;63 (13):1253-1261 [PubMed]
Nolte F. Improved assessment of functional severity of coronary artery stenosis by analysis of combined intracoronary pressure and flow velocity signals. s.l.: s.n.; 2014. 192p. ISBN 9789090281841 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Spaan JAE, Piek JJ; copromotor(s): Siebes M)
Nolte F, van de Hoef TP , de Klerk W, Baan J Jr, Lockie TPE, Spaan JAE, Piek JJ, Siebes M, Functional coronary stenosis severity assessed from the mean pressure gradient-velocity relationship obtained by contrast medium-induced submaximal hyperaemia. EUROINTERVENTION 2014;10 (3):320-328 [PubMed]
Nolte F, van de Hoef TP , Meuwissen M, Voskuil M, Chamuleau SAJ, Henriques JPS, Verberne HJ, van Eck-Smit BLF, Koch KT, de Winter RJ, Spaan JAE, Tijssen JGP, Siebes M, Piek JJ, Increased hyperaemic coronary microvascular resistance adds to the presence of myocardial ischaemia. EUROINTERVENTION 2014;9 (12):1423-1431 [PubMed]
Rolandi MC. Cardiac-coronary interactions in humans: Mechanistic insights from wave intensity analysis. s.l.: s.n.; 2014. 179p. ISBN 9789090282664 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Spaan JAE, Piek JJ; copromotor(s): Siebes M)
Rolandi MC, de Silva K, Lumley M, Lockie TPE, Clapp B, Spaan JAE, Perera D, Siebes M, Wave speed in human coronary arteries is not influenced by microvascular vasodilation: implications for wave intensity analysis. BASIC RES CARDIOL 2014;109 (2):405 [PubMed]
Schuster A, Zarinabad N, Ishida M, Sinclair M, van den Wijngaard JPHM, Morton G, Hautvast GLTF, Bigalke B, van Horssen P, Smith N, Spaan JAE, Siebes M, Chiribiri A, Nagel E, Quantitative assessment of magnetic resonance derived myocardial perfusion measurements using advanced techniques: microsphere validation in an explanted pig heart system. J CARDIOVASC MAGN R 2014;16 (1):82 [PubMed]
van Dam A, Schwarz JCV, de Vos J, Siebes M, Sijen T, van Leeuwen TG, Aalders MCG, Lambrechts SAG, Oxidation monitoring by fluorescence spectroscopy reveals the age of fingermarks. ANGEW CHEM INT EDIT 2014;53 (24):6272-6275 [PubMed]
van de Hoef TP , Nolte F, Echavarría-Pinto M, van Lavieren MA, Damman P, Chamuleau SAJ, Voskuil M, Verberne HJ, Henriques JPS, van Eck-Smit BLF, Koch KT, de Winter RJ, Spaan JAE, Siebes M, Tijssen JGP, Meuwissen M, Piek JJ, Impact of hyperaemic microvascular resistance on fractional flow reserve measurements in patients with stable coronary artery disease: insights from combined stenosis and microvascular resistance assessment. HEART 2014;100 (12):951-959 [PubMed]
van de Hoef TP , van Lavieren MA, Damman P, Delewi R, Piek MA, Chamuleau SAJ, Voskuil M, Henriques JPS, Koch KT, de Winter RJ, Spaan JAE, Siebes M, Tijssen JGP, Meuwissen M, Piek JJ, Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity. CIRC-CARDIOVASC INTE 2014;7 (3):301-311 [PubMed]
van Horssen P, Siebes M, Spaan JAE, Hoefer IE, van den Wijngaard JPHM, Innate collateral segments are predominantly present in the subendocardium without preferential connectivity within the left ventricular wall. J PHYSIOL-LONDON 2014;592 (Part 5):1047-1060 [PubMed]
van Horssen P, van den Wijngaard JPHM, Brandt MJ, Hoefer IE, Spaan JAE, Siebes M, Perfusion territories subtended by penetrating coronary arteries increase in size and decrease in number toward the subendocardium. AM J PHYSIOL-HEART C 2014;306 (4):H496-H504 [PubMed]
Geenen T, van Horssen P, Spaan JAE, Siebes M, van den Wijngaard JPHM. Iterative deblurring of large 3D datasets from cryomicrotome imaging using an array of GPUs in: Yuen DA, Wang L, Ge W, Johnsson L, Chi X, Shi Y, editors. GPU Solutions to Multi-scale Problems in Science and Engineering. Berlin: Springer; 2013. 10529, p. 537-549
Goyal A, Lee J, Lamata P, van den Wijngaard J, van Horssen P, Spaan J, Siebes M, Grau V, Smith NP, Model-based vasculature extraction from optical fluorescence cryomicrotome images. IEEE T MED IMAGING 2013;32 (1):56-72 [PubMed]
Johnson NP, Kirkeeide RL, Asrress KN, Fearon WF, Lockie T, Marques KMJ, Pyxaras SA, Rolandi MC, van 't Veer M, de Bruyne B, Piek JJ, Pijls NHJ, Redwood S, Siebes M, Spaan JAE, Gould KL, Does the instantaneous wave-free ratio approximate the fractional flow reserve?. J AM COLL CARDIOL 2013;61 (13):1428-1435 [PubMed]
Koudstaal S, Jansen Of Lorkeers SJ, van Slochteren FJ, van der Spoel TIG, van de Hoef TP , Sluijter JP, Siebes M, Doevendans PA, Piek JJ, Chamuleau SAJ, Assessment of coronary microvascular resistance in the chronic infarcted pig heart. J CELL MOL MED 2013;17 (9):1128-1135 [PubMed]
Nolte F, Hyde ER, Rolandi C, Lee J, van Horssen P, Asrress K, van den Wijngaard JPHM, Cookson AN, van de Hoef T, Chabiniok R, Razavi R, Michler C, Hautvast GLTF, Piek JJ, Breeuwer M, Siebes M, Nagel E, Smith NP, Spaan JAE, Myocardial perfusion distribution and coronary arterial pressure and flow signals: clinical relevance in relation to multiscale modeling, a review. MED BIOL ENG COMPUT 2013;51 (11):1271-1286 [PubMed]
Siebes M, Coronary flow and physiology beyond the stenosis. HEART METAB 2013;58:4-9
van de Hoef TP , Meuwissen M, Escaned J, Davies JE, Siebes M, Spaan JAE, Piek JJ, Fractional flow reserve as a surrogate for inducible myocardial ischaemia. NAT REV CARDIOL 2013;10 (8):439-452 [PubMed]
van de Hoef TP , Meuwissen M, Escaned J, Davies JE, Siebes M, Spaan JAE, Piek JJ, Fractional flow reserve as a surrogate for inducible myocardial ischaemia (vol 10, pg 439, 2013). NAT REV CARDIOL 2013;10 (12):682
van den Wijngaard JPHM, Schwarz JCV, van Horssen P, van Lier MGJTB, Dobbe JGG, Spaan JAE, Siebes M, 3D Imaging of vascular networks for biophysical modeling of perfusion distribution within the heart. J BIOMECH 2013;46 (2):229-239 [PubMed]
van Horssen P, van den Wijngaard JPHM, Nolte F, Hoefer I, Haverslag R, Spaan JAE, Siebes M. Extraction of coronary vascular tree and myocardial perfusion data from stacks of cryomicrotome images in: Ourselin S, Rueckert D, Smith N, editors. Functional Imaging and Modeling of the Heart : 7th International Conference, FIMH 2013, London, UK, June 20-22, 2013 : Proceedings. Berlin; Heidelberg: Springer; 2013., p. 486-494
Cookson AN, Lee J, Michler C, Chabiniok R, Hyde E, Nordsletten DA, Sinclair M, Siebes M, Smith NP, A novel porous mechanical framework for modelling the interaction between coronary perfusion and myocardial mechanics. J BIOMECH 2012;45 (5):850-855 [PubMed]
Lockie TPE, Rolandi MC, Guilcher A, Perera D, de Silva K, Williams R, Asrress KN, Patel K, Plein S, Chowienczyk P, Siebes M, Redwood SR, Marber MS, Synergistic Adaptations to Exercise in the Systemic and Coronary Circulations That Underlie the Warm-Up Angina Phenomenon. CIRCULATION 2012;126 (22):2565-2574 [PubMed]
Nolte F, van de Hoef TP, de Klerk W, Spaan JAE, Piek JJ, Siebes M, Functional Assessment of Coronary Artery Stenosis by Contrast-Induced Reactive Hyperemia. IFMBE PROC 2012;37:528-531
Rolandi MC, Lockie T, Guilcher A, Perera D, Redwood S, Marber M, Siebes M, Effect of Warm-Up Exercise Studied with Wave Intensity Analysis. IFMBE PROC 2012;37:478-480
Rolandi MC, Nolte F, van de Hoef TP , Remmelink M, Baan J Jr, Piek JJ, Spaan JAE, Siebes M, Coronary wave intensity during the Valsalva manoeuvre in humans reflects altered intramural vessel compression responsible for extravascular resistance. J PHYSIOL-LONDON 2012;590 (18):4623-4635 [PubMed]
Schneiders JJ, Ferns SP, van Ooij P, Siebes M, Nederveen AJ, van den Berg R, van Lieshout J, Jansen G, VanBavel E, Majoie CB, Comparison of Phase-Contrast MR Imaging and Endovascular Sonography for Intracranial Blood Flow Velocity Measurements. AM J NEURORADIOL 2012;33 (9):1786-1790 [PubMed]
van de Hoef TP , Nolte F, Damman P, Delewi R, Bax M, Chamuleau SAJ, Voskuil M, Siebes M, Tijssen JGP, Spaan JAE, Piek JJ, Meuwissen M, Diagnostic Accuracy of Combined Intracoronary Pressure and Flow Velocity Information During Baseline Conditions Adenosine-Free Assessment of Functional Coronary Lesion Severity. CIRC-CARDIOVASC INTE 2012;5 (4):508-514 [PubMed]
van de Hoef TP , Nolte F, Delewi R, Henriques JPS, Spaan JAE, Tijssen JGP, Siebes M, Wykrzykowska JJ, Stone GW, Piek JJ, Intracoronary hemodynamic effects of pressure-controlled intermittent coronary sinus occlusion (PICSO): results from the First-In-Man Prepare PICSO Study. J INTERV CARDIOL 2012;25 (6):549-556 [PubMed]
van de Hoef TP , Nolte F, Rolandi MC, Piek JJ, van den Wijngaard JPHM, Spaan JAE, Siebes M, Coronary pressure-flow relations as basis for the understanding of coronary physiology. J MOL CELL CARDIOL 2012;52 (4):786-793 [PubMed]
van de Hoef TP , Nolte F, Siebes M, Spaan JAE, Damman P, Delewi R, Tijssen JGP, Piek JJ, Bax M, Chamuleau SAJ, Voskuil M, Meuwissen M, Response to Michiels et al and Sen et al Regarding Article, "Diagnostic Accuracy of Combined Intracoronary Pressure and Flow Velocity Information During Baseline Conditions: Adenosine-Free Assessment of Functional Coronary Lesion Severity". CIRC-CARDIOVASC INTE 2012;5 (6):E86-E87 [PubMed]
van Horssen P. Multiscale analysis of coronary branching and collateral connectivity: Coupling vascular structure and perfusion in 3D. Amsterdam: s.n.; 2012. 161p. ISBN 978-90-889-153-21 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Spaan JAE; copromotor(s): Siebes M, van den Wijngaard JPHM)
van Horssen P, Siebes M, Spaan JAE, van den Wijngaard JPHM, High-Resolution Spatial Quantification of Coronary Collaterals with an Imaging Cryomicrotome. IFMBE PROC 2012;37:458-461
Verhoeff BJ, van de Hoef TP , Spaan JAE, Piek JJ, Siebes M, Minimal effect of collateral flow on coronary microvascular resistance in the presence of intermediate and noncritical coronary stenoses. AM J PHYSIOL-HEART C 2012;303 (4):H422-H428 [PubMed]
Lagerveld BW, van Horssen P, Laguna MP, van den Wijngaard JPHM, Siebes M, Wijkstra H, de La Rosette JJMCH, Spaan JAE, Gradient changes in porcine renal arterial vascular anatomy and blood flow after cryoablation. J UROLOGY 2011;186 (2):681-686 [PubMed]
Smeele KMA, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O , Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ, Disruption of Hexokinase II-Mitochondrial Binding Blocks Ischemic Preconditioning and Causes Rapid Cardiac Necrosis. CIRC RES 2011;108 (10):1165-9 [PubMed]
Smith N, de Vecchi A, McCormick M, Nordsletten D, Camara O, Frangi AF, Delingette H, Sermesant M, Relan J, Ayache N, Krueger MW, Schulze WHW, Hose R, Valverde I, Beerbaum P, Staicu C, Siebes M, Spaan J, Hunter P, Weese J, Lehmann H, Chapelle D, Rezavi R, euHeart: personalized and integrated cardiac care using patient-specific cardiovascular modelling. INTERFACE FOCUS 2011;1 (3):349-364 [PubMed]
van den Wijngaard JPHM, Schulten H, van Horssen P, ter Wee RD, Siebes M, Post MJ, Spaan JAE, Porcine coronary collateral formation in the absence of a pressure gradient remote of the ischemic border zone. AM J PHYSIOL-HEART C 2011;300 (5):H1930-H1937 [PubMed]
Waters SL, Alastruey J, Beard DA, Bovendeerd PHM, Davies PF, Jayaraman G, Jensen OE, Lee J, Parker KH, Popel AS, Secomb TW, Siebes M, Sherwin SJ, Shipley RJ, Smith NP, van de Vosse FN, Theoretical models for coronary vascular biomechanics: Progress & challenges. PROG BIOPHYS MOL BIO 2011;104 (1-3):49-76 [PubMed]
Ferns SP, Schneiders JJ, Siebes M, van den Berg R, van Bavel ET, Majoie CB, Intracranial Blood-Flow Velocity and Pressure Measurements Using an Intra-Arterial Dual-Sensor Guidewire. AM J NEURORADIOL 2010;31 (2):324-326 [PubMed]
Rolandi M, Remmelink M, Nolte F, Baan J, Piek JJ, Spaan JAE, Siebes M, Effect of the Valsalva maneuver on cardiac-coronary interaction assessed by wave intensity analysis. CONF PROC IEEE ENG MED BIOL SOC 2010;1:3776-3779 [PubMed]
Siebes M. Intracoronary Doppler-based techniques for stenosis apparaisal in: Escaned J, Serruys PW, editors. Coronary Stenosis Imaging, Structure and Physiology. Toulouse: PCR Publishing; 2010., p. 377-400
Siebes M, Ventikos Y, The role of biofluid mechanics in the assessment of clinical and pathological observations: sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008 Pasadena, California. ANN BIOMED ENG 2010;38 (3):1216-1224 [PubMed]
van den Wijngaard JPHM, van Horssen P, ter Wee R, Coronel R, de Bakker JM, de Jonge N, Siebes M, Spaan JAE, Organization and collateralization of a subendocardial plexus in end-stage human heart failure. AM J PHYSIOL-HEART C 2010;298 (1):H158-H162 [PubMed]
van Horssen P, Siebes M, Hoefer I, Spaan JAE, van den Wijngaard JPHM, Improved detection of fluorescently labeled microspheres and vessel architecture with an imaging cryomicrotome. MED BIOL ENG COMPUT 2010;48 (8):735-744 [PubMed]
Verhoeff BJ. Simultaneous pressure and flow velocity measurements in diagnosis and treatment of coronary artery disease. s.l.: s.n.; 2010. 160p. ISBN 9789090257433 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Piek JJ, Spaan JAE; copromotor(s): Siebes M)
Avolio A, Westerhof BE, Siebes M, Tyberg JV, Arterial hemodynamics and wave analysis in the frequency and time domains: an evaluation of the paradigms. MED BIOL ENG COMPUT 2009;47 (2):107-110 [PubMed]
Meuwissen M, Siebes M, Chamuleau SAJ, Verhoeff BJ, Henriques JPS, Spaan JAE, Piek JJ, Role of fractional and coronary flow reserve in clinical decision making in intermediate coronary lesions. FUTURE CARDIOL 2009;1 (2):237-255
Siebes M, Kolyva C, Verhoeff BJ, Piek JJ, Spaan JA, Potential and limitations of wave intensity analysis in coronary arteries. MED BIOL ENG COMPUT 2009;47 (2):233-239 [PubMed]
van den Wijngaard JPHM, Siebes M, Westerhof BE, Comparison of arterial waves derived by classical wave separation and wave intensity analysis in a model of aortic coarctation. MED BIOL ENG COMPUT 2009;47 (2):211-220 [PubMed]
Kolyva C. Analysis of pulsatile coronary pressure and flow velocity: looking beyond means. s.l.: s.n.; 2008. 150p. ISBN 9789090227375 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Spaan JAE, Piek JJ; copromotor(s): Siebes M)
Kolyva C, Spaan JAE, Piek JJ, Siebes M, Windkesselness of coronary arteries hampers assessment of human coronary wave speed by single-point technique. AM J PHYSIOL-HEART C 2008;295 (2):H482-H490 [PubMed]
Kolyva C, Verhoeff BJ, Spaan JAE, Piek JJ, Siebes M, Increased diastolic time fraction as beneficial adjunct of alpha(1)-adrenergic receptor blockade after percutaneous coronary intervention. AM J PHYSIOL-HEART C 2008;295 (5):H2054-H2060 [PubMed]
Meuwissen M, Chamuleau SAJ, Siebes M, de Winter RJ, Koch KT, Dijksman LM, van den Berg AJ, Tijssen JGP, Spaan JAE, Piek JJ, The prognostic value of combined intracoronary pressure and blood flow velocity measurements after deferral of percutaneous coronary intervention. CATHETER CARDIO INTE 2008;71 (3):291-297 [PubMed]
Nolte F, Remmelink M, van den Wijngaard JPHM, Zweers SJ, Baan J, Piek JJ, Siebes M, editors, Influence on branching and tapering on intracoronary pressure and flow velocity: comparison of axial measurement location. Antwerpen: Med Biol Eng & Computing; 2008. -p. ISBN 978 3 540 89208 3 (Proc. 4th Eu Conf. MBEC; )
Spaan J, Kolyva C, van den Wijngaard J, ter Wee R, van Horssen P, Piek J, Siebes M, Coronary structure and perfusion in health and disease. PHILOS T R SOC A 2008;366 (1878):3137-3153 [PubMed]
van den Wijngaard JPHM, Kolyva C, Siebes M, Dankelman J, van Gemert MJC, Piek JJ, Spaan JAE, Model prediction of subendocardial perfusion of the coronary circulation in the presence of an epicardial coronary artery stenosis. MED BIOL ENG COMPUT 2008;46 (5):421-432 [PubMed]
van den Wijngaard JPHM, van Horssen P, ter Wee RD, Siebes M, Schulten H, Post MJ, Spaan JAE, editors, Identification of coronary collaterals in imaging cryomicrotome datasets. Antwerpen: Med Biol Eng & Computing; 2008. -p. ISBN 978 3 540 89208 3 (Proc. 4 th EU Conf. MBEC; )
van Horssen P, van den Wijngaard JPHM, Siebes M, Spaan JAE, editors, Improved regional myocardial perfusion measurement by means of an imaging cryomicrotome. Antwerpen: Med Biol Eng & Computing; 2008. -p. ISBN 978 3 540 89208 3 (Proc. 4th EU Conf. MBEC; )
Siebes M, Senhadji L, VanderSloten J, Saranummi N, Biomedical Engineering Trends in Europe. IEEE ENG MED BIOL 2007;26 (3):12-13
Siebes M, Viceconti M, Maglaveras N, Kirkpatrick CJ, Engineering for health. IEEE ENG MED BIOL 2007;26 (3):53-59 [PubMed]
Verberne HJ, Meuwissen M, Chamuleau SAJ, Verhoeff BJ, van Eck-Smit BLF, Spaan JAE, Piek JJ, Siebes M, Effect of simultaneous intracoronary guidewires on the predictive accuracy of functional parameters of coronary lesion severity. AM J PHYSIOL-HEART C 2007;292 (5):H2349-H2355 [PubMed]
Kern MJ, Lerman A, Bech JW, de Bruyne B, Eeckhout E, Fearon WF, Higano ST, Lim MJ, Meuwissen M, Piek JJ, Pijls NHJ, Siebes M, Spaan JAE, Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. CIRCULATION 2006;114 (12):1321-1341 [PubMed]
Siebes M, Spaan JAE, vander Sloten J. Dreaming of a European platform 'engineering for health" - a vison for the future of EU healthcare in: 2050: A health Odyssey: thought provoking ideas for policy making. Health First Europe. S.l.: s.n.; 2006., p. 12-15
Spaan JAE, Piek JJ, Hoffman JIE, Siebes M, Physiological basis of clinically used coronary hemodynamic indices. CIRCULATION 2006;113 (3):446-455 [PubMed]
Spaan JAE, Siebes M, Verhoeff BJ, Piek JJ. The coronary circulation in: King III SB, Yeung AC, editors. Interventional cardiology. New York: McGraw-Hill; 2006., p. 25-45
Spaan J, Siebes M, Is myocardial contrast echocardiography ready to assume 'gold standard' status for quantification of collateral flow in humans?. EUR HEART J 2006;27 (13):1627; author reply 1627-1627; author reply 1628 [PubMed]
Verhoeff B, Siebes M, Meuwissen M, Spaan JAE, Piek JJ, Diagnostiek en behandeling van kransslagaderlijden geëvalueerd met simultane intracoronaire druk- en bloedstroomsnelheidsmetingen. HART BULL 2006;37 (1):4-8
Lieber BB, Siebes M, Yamaguchi T, Correlation of hemodynamic events with clinical and pathological observations. ANN BIOMED ENG 2005;33 (12):1695-1703 [PubMed]
Spaan JAE, ter Wee R, van Teeffelen JWGE, Streekstra G, Siebes M, Kolyva C, Vink H, Fokkema DS, VanBavel E, Visualisation of intramural coronary vasculature by an imaging cryomicrotome suggests compartmentalisation of myocardial perfusion areas. MED BIOL ENG COMPUT 2005;43 (4):431-435 [PubMed]
VanTeeffelen JWGE, Dekker S, Fokkema DS, Siebes M, Vink H, Spaan JAE, Hyaluronidase treatment of coronary glycocalyx increases reactive hyperemia but not adenosine hyperemia in dog hearts. AM J PHYSIOL-HEART C 2005;289 (6):H2508-H2513 [PubMed]
Verhoeff BJ, Siebes M, Meuwissen M, Atasever B, Voskuil M, de Winter RJ, Koch KT, Tijssen JGP, Spaan JAE, Piek JJ, Influence of percutaneous coronary intervention on coronary microvascular resistance index. CIRCULATION 2005;111 (1):76-82 [PubMed]
Kolyva C, Verhoeff B, Piek JJ, Spaan JAE, Siebes M, Separating diastolic duration as confounding variable in the hemodynamic effect of coronary vasodilation. IFMBE NEWS 2004;- (68):27-30
Kolyva C, Verhoeff B, Piek JJ, Spaan JAE, Siebes M, editors, Separating diastolic duration as confounding variable in the hemodynamic effect of coronary vasodilation. Ischia, Italy: MEDICON; 2004. -p. ISBN 88 7780 308 8
Meuwissen M, van der Wal AC, Siebes M, Koch KT, Chamuleau SAJ, van der Loos CM, Teeling P, de Winter RJ, Niessen HWM, Tijssen JGP, Becker AE, Piek JJ, Role of plaque inflammation in acute and recurrent coronary syndromes. NETH HEART J 2004;12 (3):106-109
Siebes M, Verhoeff BJ, Meuwissen M, de Winter RJ, Spaan JAE, Piek JJ, Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions. CIRCULATION 2004;109 (6):756-762 [PubMed]
Chamuleau SAJ, Siebes M, Meuwissen M, Koch KT, Spaan JAE, Piek JJ, Association between coronary lesion severity and distal microvascular resistance in patients with coronary artery disease. AM J PHYSIOL-HEART C 2003;285 (5):H2194-H2200 [PubMed]
Meuwissen M, Siebes M, Chamuleau SAJ, Tijssen JGP, Spaan JAE, Piek JJ, Intracoronary pressure and flow velocity for hemodynamic evaluation of coronary stenoses. EXPERT REV CARDIOVASC THER 2003;1 (3):89-96 [PubMed]
Meuwissen M. Pathomorphological and physiological characteristics of coronary artery disease. S.l.: s.n.; 2002. 202p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Piek JJ, Becker AE; copromotor(s): van der Wal AC, Siebes M)
Meuwissen M, Siebes M, Chamuleau SAJ, van Eck-Smit BLF, Koch KT, de Winter RJ, Tijssen JGP, Spaan JAE, Piek JJ, Hyperemic stenosis resistance index for evaluation of functional coronary lesion severity. CIRCULATION 2002;106 (4):441-446 [PubMed]
Meuwissen M, Siebes M, Spaan JAE, Piek JJ, Rationale of combined intracoronary pressure and flow velocity measurements. Z KARDIOL 2002;91 (Suppl. 3):108-112 [PubMed]
Siebes M, Chamuleau SAJ, Meuwissen M, Piek JJ, Spaan JAE, Influence of hemodynamic conditions on fractional flow reserve: parametric analysis of underlying model. AM J PHYSIOL-HEART C 2002;283 (4):H1462-H1470 [PubMed]
Meuwissen M, Chamuleau SA, Siebes M, Schotborgh CE, Koch KT, de Winter RJ, Bax M, de Jong A, Spaan JA, Piek JJ, Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions. CIRCULATION 2001;103 (2):184-187 [PubMed]
Spaan JAE, Siebes M, Piek JJ. Coronary Circulation and hemodynamics in: Sperelakis N, Kurachi Y, Terzic A, Cohen M, editors. Heart Physiology and Pathophysiology. San Diego: Academic Press; 2001. 4, p. 19-44
Black CM, Lang EV, Kusnick CA, Siebes M, Barnhart W, Berbaum KS, Hoffman EA, 1996 AUR Memorial Award. Densitometric analysis of eccentric vascular stenoses: comparison of CO2 and iodinated contrast media. ACAD RADIOL 1996;3 (12):985-993 [PubMed]
Kusnick CA, Black CM, Lang EV, Siebes M, Barnhart W, Hoffman E. Comparison of conventional and CO2 quantitative angiography in: Hoffman EA, Acharya RS, editors. Medical Imaging 1996: Physiology and Function from Multidimensional Images. S.l.: SPIE; 1996. 2707, p. 107-118
Miller EM, Kreder KJ, Siebes M, Design and development of an electromechanical ultrasound probe holder for urodynamics testing. J BIOMECH 1996;29 (10):1361-1364 [PubMed]
Siebes M, Campbell CS, D'Argenio DZ, Fluid dynamics of a partially collapsible stenosis in a flow model of the coronary circulation. J BIOMECH ENG-T ASME 1996;118 (4):489-497 [PubMed]
Siebes M, Herman KA, De Jong SC, McKay CR, editors, Mechanical effect of contrast injection on coronary artery diameter during angiography. Los Alamitos CA: IEEE Computer Society; 1995. p.p. 745-748p. ISBN 0 8186 6570 x (Computers in Cardiology; )
Sonka M, Zhang X, Siebes M, Bissing MS, Dejong SC, Collins SM, McKay CR, Segmentation of intravascular ultrasound images: a knowledge-based approach. IEEE T MED IMAGING 1995;14 (4):719-732 [PubMed]
Sonka M, Zhang X, Siebes M, DeJong S, McKay CR, Collins SM, editors, Automated segmentation of coronary wall and plaque from intravascular ultrasound image sequences. Los Alamitos CA: IEEE Computer Society; 1995. p.p. 281-284p. ISBN 0 8186 6570 x (Computers in Cardiology; )
Stiel GM, Lattermann A, Schaps KP, Siebes M, Nienaber CA, Effect of contrast injection on coronary artery pressure and dimension during angiography. COMPUT CARDIOL 1995;1995:157-160
Siebes M, Chada RR, Zhang X, Sonka M, McKay CM, Collins SM. Biomechanical characterization of blood vessel and plaque from intravascular ultrasound images in: Hoffman EA, Acharya RS, editors. Medical Imaging 1994: Physiology and Function from Multidimensional Images. S.l.: SPIE 2168; 1994. SPIE 2168, p. 33-42
Sonka M, Zhang X, Siebes M, Chada RR, McKay CM, Collins SM. Automated detectiion of wall and plaque borders in intravascular ultrasound images in: Hoffman EA, Acharya RS, editors. Medical Imaging 1994: Physiology and Function from Multidimensional Images. S.l.: SPIE 2168; 1994. SPIE 2168, p. 13-22
Elizondo D, Siebes M, editors, Modeling a diseased artery with a soft plaque. S.l.: ASME BED; 1993. p.p. 591-594p. ISBN 0 7918 1031 3 (Advances in Bioengineering; 26)
Herrington DM, Siebes M, Sokol DK, Siu CO, Walford GD, Variability in measures of coronary lumen dimensions using quantitative coronary angiography. J AM COLL CARDIOL 1993;22 (4):1068-1074 [PubMed]
Herrington DM, Siebes M, Walford GD, Sources of error in quantitative coronary angiography. CATHET CARDIOVASC DIAGN 1993;29 (4):314-321 [PubMed]
John B, Siebes M, editors, Flow studies in sequential stenoses: Comparison of a rigd and a flexible eccentric stenos in series with a concentric stenosis.. S.l.: ASME BED; 1993. p.p. 275-278p. ISBN 0 7918 1031 3 (Advances in Bioengineering; 26)
John B, Siebes M, editors, Effects of stenoses compliance on flow through sequential stenoses.. S.l.: ASME BED; 1992. p.p. 383-386p. ISBN 0 7918 1116 6 (Advances in Bioengineering; 22)
Siebes M, John B, editors, Pressure losses across sequential stenoses in collasible tubing. S.l.: ASCE; 1992. p.p. 832-835p. ISBN 0 8726 2867 1 (ASCE Engineering Mechanics Conference; )
Siebes M, editor, The effect of nonlinear wall mechanics on compliant coronary stenoses: A flow simulation study. S.l.: ASME BED; 1991. p.p. 345-348p. ISBN 0 7918-08989 0 (Advances of Bioengineering; 20)
Flaherty AL, Siebes M, editors, Physical model of a compliant stenosis with a flexible, eccentric plaque.. S.l.: ASME-BED; 1990. p.p. 365-368p. ISBN 0 7918 0567 x (Advances in Bioengineering; 17)
Siebes M, D Argenio DZ, editors, Mathematical model of flow through a partially collapsible coronary stenosis. Washington: ASME BED; 1990. 139-142p. ISBN 0 7918 0576 (Advances in Bioengineering; 17)
Selzer RH, Hagerty C, Azen SP, Siebes M, Lee P, Shircore A, Blankenhorn DH, Precision and reproducibility of quantitative coronary angiography with applications to controlled clinical trials. A sampling study. J CLIN INVEST 1989;83 (2):520-526 [PubMed]
Selzer RH, Siebes M, Hagerty C, Azen SP, Lee P, Blankenhorn DH, Shircore A, editors, Effects of cardiac phase on diameter measurements for coronary angiograms. Long Beach CA: IEEE Copmuters Society; 1989. p.p. 363-366p. ISBN 0 8186 1949 x (Computers in Cardiology; )
Herrington DM, Siebes M, Walford GD, Selzer RH, Derivative-based edge detection in quantitative coronary angiography is not independent of vessel size. COMPUT CARDIOL 1988;1988:351-354
Nienaber CA, Siebes M, Bleifeld W, Perkutane transluminale Angioplastie von koronaren Bypass-Gefässen. Quantitative Erfassung und Langzeitergebnisse. DEUT MED WOCHENSCHR 1986;111 (39):1469-1473 [PubMed]
Siebes M, D'Argenio DZ, Selzer RH, Computer assessment of hemodynamic severity of coronary artery stenosis from angiograms. COMPUT METH PROG BIO 1985;21 (2):143-152 [PubMed]
Siebes M, Selzer RH, editors, How accurate is the coronary catheter as a reference in quantitative coronary angiography?. Long Beach: IEEE Computer Society; 1985. p.p. 9-14p. ISBN 0 8186 0733 5 (Computers in Cardiology; Plenary session)
Bassenge E, Becker HJ, Siebes M, et al -, editors, Koronarerkrankungen (5. Aufl.). Berlin: Springer; 1984. 1388p. ISBN 978-3-642-69452-3, 978-3-642-69451-6 (Handbuch der inneren Medizin; 9:3)
Gottwik MG, Siebes M, Kirkeeide R, Schaper W, Hämodynamik von Koronarstenosen. Z KARDIOL 1984;73 (Suppl. 2):47-53 [PubMed]
Gottwik MG, Staemmler G, Mueller KD, Siebes M, Kindler M, Winkler B, Schlepper M. Introduction and clinical evaluation of a computer-assisted method for determination of regional wall motion of the left ventrical in: Gottwik MG, Staemmler G, Mueller KD, Siebes M, Kindler M, Winkler B, Schlepper M, editors. Ventricular Wall Motion. Stuttgart: Georg Thieme Verlag; 1984., p. 113-121
Gottwik MG, Staemmler G, Mueller KD, Siebes M, Kindler M, Winkler B, Schlepper M, editors, Ventricular Wall Motion. Stuttgart: Georg Thieme Verlag; 1984. 200p. ISBN 0 8657 7146 4 (Ventricular Wall Motion; )
Siebes M. Biophysics of arterial stenoses in: Roskamm H, editor. Handbook of Internal Medicine. Berlin: Springer Verlag Berlin; 1984., p. 95-115
Gottwik MG, Siebes M, Bahawar H, Müller A, Wand T, Schlepper M, Quantitative angiographic assessment of coronary stenoses: problems and pitfalls. Z KARDIOL 1983;72 (Suppl. 3):111-115 [PubMed]
Siebes M, Gottwik MG, Schlepper M, editors, Influence of geometric errors in quantitative angiography on the evaluation of stenotic hemodynamics. Long Beach: IEEE Computer Society; 1983. p.p. 385-388p. ISBN 0 8186 0496 4 (Computers in Cardiology; )
Siebes M, Gottwik MG, Schlepper M, editors, Quantitative angiography: experimental studies on the representation of model coronary arteries on angiographic film. S.l.: IEEE Computer Society; 1983. p.p. 65-70p. (IEEE Computer Society; )
Siebes M, Gottwik MG, Schlepper M, editors, Qualitative and quantitative experimental studies on the evaluation of model coronary arteries from angiograms. Long Beach: IEEE Computer Society; 1982. p.p. 211-214p. ISBN 0 8186 2224 1 (Computers in Cardiology; )
Siebes M, GOTTWIK M, Schlepper M, QUANTITATIVE ANGIOGRAPHY - EXPERIMENTAL STUDIES ON THE REPRESENTATION OF MODEL CORONARY-ARTERIES IN ANGIOGRAPHIC FILMS. P SOC PHOTO-OPT INST 1982;375:65-70
Key publications

Lockie TPE, Rolandi MC, Guilcher A, Perera D, de Silva K, Williams R, Asrress KN, Patel K, Plein S, Chowienczyk P, Siebes M, Redwood SR, Marber MS, Synergistic Adaptations to Exercise in the Systemic and Coronary Circulations That Underlie the Warm-Up Angina Phenomenon. CIRCULATION 2012;126 (22):2565-2574 [PubMed]
Rolandi MC, de Silva K, Lumley M, Lockie TPE, Clapp B, Spaan JAE, Perera D, Siebes M, Wave speed in human coronary arteries is not influenced by microvascular vasodilation: implications for wave intensity analysis. BASIC RES CARDIOL 2014;109 (2):405 [PubMed]
Jeremias A, Maehara A, Généreux P, Asrress KN, Berry C, de Bruyne B, Davies JE, Escaned J, Fearon WF, Gould KL, Johnson NP, Kirtane AJ, Koo BK, Marques KM, Nijjer S, Oldroyd KG, Petraco R, Piek JJ, Pijls NH, Redwood S, Siebes M, Spaan JAE, van 't Veer M, Mintz GS, Stone GW, Multicenter core laboratory comparison of the instantaneous wave-free ratio and resting Pd/Pa with fractional flow reserve: the RESOLVE study. J AM COLL CARDIOL 2014;63 (13):1253-1261 [PubMed]
van de Hoef TP , Siebes M, Spaan JAE, Piek JJ, Fundamentals in clinical coronary physiology: why coronary flow is more important than coronary pressure. EUR HEART J 2015;36 (47):3312-339a [PubMed]
Rolandi MC, Wiegerinck EMA, Casadonte L, Yong ZY, Koch KT, Vis M, Piek JJ, Baan J Jr, Spaan JAE, Siebes M, Transcatheter Replacement of Stenotic Aortic Valve Normalizes Cardiac-Coronary Interaction by Restoration of Systolic Coronary Flow Dynamics as Assessed by Wave Intensity Analysis. CIRC-CARDIOVASC INTE 2016;9 (4):e002356 [PubMed]


All Publications

Curriculum Vitae

Education:
1981  Diplom-Ing. Technical Health Sciences, Univ. of Applied Sciences, Giessen, Germany
          Thesis (with honors): Quantitative Angiography: In vitro experiments for the evaluation of a computer program for the geometric and hemodynamic assessment of stenoses from angiograms. 
1984  MSc Biomedical Engineering, Univ. of Southern California, Los Angeles, CA
1989  PhD Biomedical Engineering, Univ. of Southern California, Los Angeles, CA
           Thesis: Modeling and simulation of a compliant coronary stenosis during the cardiac cycle.

Professional Experience:
2011- date  Assoc. Professor, Biomedical Engineering and Physics, AMC, Amsterdam
2007- date  Principal Investigator, Academic Medical Center, Amsterdam
2002-2011  Univ. Docent (tenured), Dept. of Biomed. Engineering & Physics, AMC, Amsterdam
1997-2002  Senior Res. Scientist (part-time), Dept. of Cardiology, AMC, Amsterdam
1996           Visiting Scientist, Cardiovasc. Research Inst., AMC, University of Amsterdam
1989-1997  Asst. Professor, Biomedical Engineering, University of Iowa, Iowa City, IA
1983-1989  Scientist III (acad. part-time), Biomed. Image Proc. Group, JPL/CalTech, Pasadena, CA
1981-1983  Research Engineer, Dept. of Cardiology, Kerckhoff Clinic, Bad Nauheim, Germany
1979-1981  Research Asst., Exp. Cardiology, Max-Planck-Inst. for Heart & Lung Research, Bad Nauheim, Germany

Honors & Awards:
1983 Fulbright Scholarship
1984 Fellowship, American Assoc. of Univ. Women (AAUW)
1985 & 1986 Amelia Earhart Fellowship, ZONTA International
1986 Scholarship, Germanistic Society of America
1987 Scholarship, Phi Beta Kappa (USC)
1992 Outstanding Teacher Award, Univ. of Iowa
1992 Iowa Career Development Award for Translational Research, Univ. of Iowa
1994 Alumni Member, Tau Beta Pi (Eng. Honors Soc.)
2010 Fellow, American Inst. for Medical and Biol. Engineering (AIMBE)
2012 Fellow, European Alliance for Medical and Biol. Engineering and Science (EAMBES)

Society Memberships: Sigma Xi, IEEE-EMBS (Senior Member), American Heart Assoc., American Physiol. Society, Dutch Soc. for Biophysics & Biomed. Technology, Dutch Soc. for Microcirc. and Vasc. Biology

Research Grants: Sigma Xi, NIH, NSF, Whitaker Foundation, Carver Scientific Research (UI), GE Foundation Faculty Fellowship, Dutch Heart Foundation, European Community (FP7-ICT euHeart), Center for Translational Molecular Medicine (CTMM Eminence), Neth. Org. for Health Research & Development (ZonMw), Dutch Science Foundation (NWO) Investment Grant

Research programmes

Cardiovascular Hemodynamics and Perfusion

The research of the CV Hemodynamics & Perfusion group encompasses multidisciplinary investigations ranging from bench to bedside. Mechanistic research is carried out in areas of coronary disease and microvascular pathologies in humans. Experimental projects on vascular network analysis and regional perfusion complement and support the interpretation of the functional clinical data. Physiological measurements, image analysis and biofluid mechanics are integrated with model-based analysis in clinical and pre-clinical studies.
The projects are carried out in close collaboration with basic science and clinical departments, and with national and international as well as industrial partners.
 

Functional assessment of coronary epicardial and microvascular pathophysiology:
Aim: to advance diagnostic and therapeutic capabilities.
Novel approaches to analyze intracoronary hemodynamic signals obtained with sensor-equipped guide wires (Prof. dr. J.J. Piek) are developed to gain mechanistic insight into dysfunction of the coronary microcirculation in humans, associated with epicardial disease, diabetes, acute myocardial infarction, heart failure or aortic stenosis. In collaboration with King's College London, we investigate coronary hemodynamic signals.

Vascular network adaptation and regional perfusion

Aim: to understand the role of microvascular structure in perfusion distribution and its adaptation in pathophysiological conditions.
A unique 3D imaging cryomicrotome has been developed in our department (Prof. dr. ir. J. A. Spaan) and is used to visualize and quantify detailed vascular networks and segmental perfusion by 3D imaging of fluorescently labeled markers (vascular casting, microspheres, cells, etc). Focus is on coronary adaptation to acute and chronic local oxygen deficiency as induced by a stenosis, cardiomyopathies, or pressure overload. Novel analysis methods applied to hemodynamic measurements are utilized together with network models to support the interpretation of experimental and clinical data. This line of research extends to applications in urology, neurology, pathology and oncology. An NWO Veni project (Dr. J.PHM van den Wijngaard) focuses on microvascular adaptation in heart failure.

Pre-clinical investigation of neovascularization in co-localization with labeled biomarkers is carried out within the EMINENCE project supported by the Center for Translational Molecular Medicine (CTMM) and the Netherlands Heart Foundation.

We participated in the EC funded FP7 project euHeart (www.euheart.eu) which aims to develop individualized, computer-based, human heart models using patient-specific data and multi-scale modeling techniques. Much of our research is conceptually embedded in the Virtual Physiological Human initiative (www.vph-institute.org).

With support from a recent NWO Investment grant, we are developing a 3D Fluorescent Imaging Cryomicrotome System (3D-FICS) for high-resolution multispectral biomedical structure, functional and molecular imaging. 

 

Faculty
Dr. ir. M. Siebes PhD

PhD Students
L. Casadonte MSc
M.G.J.T.B. van Lier MSc
J.C.V. Schwarz MSc

Others
Drs. D.H. Ly
Prof. dr. ir. J.A.E. Spaan PhD

Other research related activities
  • Membership of editorial board / Editorship, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
  • Membership of editorial board / Editorship, INTERNATIONAL JOURNAL OF CARDIOLOGY
  • Membership of editorial board / Editorship, INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
  • Membership of medical or scientific committee, Other, Admin. Council, Int'l Federation for Medical & Biological Engineering
Current research funding
  • None reported