• Male

Dr. M.C. Brouwer MD PhD

Position: Associate professor (UHD)
Main activities: Research, Patient care, Teaching
Specialisation: Neurological infectious diseases
foto
Focus of research:

AMC Department of Neurology

The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovasculair disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.

Infection & Inflammation

We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the era's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.

Dr. Brouwer

The focus of Dr. Brouwer’s research is on neurological infectious diseases, including bacterial meningitis, viral meningitis, chronic meningitis and neuroborreliosis. To this aim he has set up a nation-wide genetic association study on community-acquired bacterial meningitis (MeninGene study) and a study on suspected meningitis and encephalitis patients (PACEM study).

During his PhD Dr. Brouwer studied host genetic factors influencing bacterial meningitis in the nationwide cohort study on culture proven bacterial meningitis. By March 2017, 2300 patients have been included in this ongoing study. With this study we showed that adjunctive dexamethasone has successfully been implemented in the Netherlands, leading to a nationwide reduction of mortality and morbidity of bacterial meningitis. Furthermore, we identified common genetic variants in complement component 3 and 5 that influence susceptibility and outcome of bacterial meningitis. In several translational research projects we used clinical and genetic data to study pathofysiology of bacterial meningitis and identify new adjunctive treatments.

 

AMC themes: Infection & Immunity, Neurological & Psychiatric Disorders
Departments: Neurology
Brouwer MC, van de Beek D, Epidemiology, diagnosis, and treatment of brain abscesses. CURR OPIN INFECT DIS 2017;30 (1):129-134 [PubMed]
Brouwer MC, van de Beek D, Management of bacterial central nervous system infections. HANDB CLIN NEUROL 2017;140:349-364 [PubMed]
Brouwer MC, van de Beek D, MONALISA: a grim picture of listeriosis. LANCET INFECT DIS 2017;17 (5):464-466 [PubMed]
Costerus JM, Brouwer MC, Bijlsma MW, van de Beek D, Community-acquired bacterial meningitis. CURR OPIN INFECT DIS 2017;30 (1):135-141 [PubMed]
Dias SP, Brouwer MC, Bijlsma MW, van der Ende A, van de Beek D, Sex-based differences in adults with community-acquired bacterial meningitis: a prospective cohort study. CLIN MICROBIOL INFEC 2017;23 (2):e9-121.e15-121.e15 [PubMed]
Fritz D, Voortman M, van de Beek D, Drent M, Brouwer MC, Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. CURR OPIN PULM MED 2017;23 (5):439-446 [PubMed]
Iovino F, Engelen-Lee JY, Brouwer M, van de Beek D, van der Ende A, Valls Seron M, Mellroth P, Muschiol S, Bergstrand J, Widengren J, Henriques-Normark B, pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion. J EXP MED 2017;214 (6):1619-1630 [PubMed]
Kasanmoentalib ES, Valls Seron M , Ferwerda B, Tanck MW, Zwinderman AH, Baas F, van der Ende A, Brouwer MC, van de Beek D, Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J NEUROINFLAMM 2017;14 (1):2 [PubMed]
Kasanmoentalib ES, Valls Seron M , Ferwerda B, Tanck MW, Zwinderman AH, Baas F, van der Ende A, Schwaeble WJ, Brouwer MC, van de Beek D, Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis (vol 14, pg 9, 2017). J NEUROINFLAMM 2017;14 (1):77 [PubMed]
Khatib U, van de Beek D, Lees JA, Brouwer MC, Adults with suspected central nervous system infection: A prospective study of diagnostic accuracy. J INFECTION 2017;74 (1):1-9 [PubMed]
Koopmans MM, Bijlsma MW, Brouwer MC, van de Beek D, van der Ende A, Listeria monocytogenes meningitis in the Netherlands, 1985-2014: A nationwide surveillance study. J INFECTION 2017;75 (1):12-19 [PubMed]
Kremer PHC, Lees JA, Koopmans MM, Ferwerda B, Arends AWM, Feller MM, Schipper K, Valls Seron M , van der Ende A, Brouwer MC, van de Beek D, Bentley SD, Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis. CLIN MICROBIOL INFEC 2017;23 (4):265E1-265E7 [PubMed]
Lees JA, Brouwer M, van der Ende A, Parkhill J, van de Beek D, Bentley SD, Within-Host Sampling of a Natural Population Shows Signs of Selection on Pde1 during Bacterial Meningitis. INFECT IMMUN 2017;85 (3):UNSP e01061-16 [PubMed]
Lees JA, Kremer PHC, Manso AS, Croucher NJ, Ferwerda B, Valls Serón M, Oggioni MR, Parkhill J, Brouwer MC, van der Ende A, van de Beek D, Bentley SD, Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis. MICROB GENOM 2017;3 (1):e000103 [PubMed]
Pannekoek Y, Huis In 't Veld RAG, Schipper K, Bovenkerk S, Kramer G, Brouwer MC, van de Beek D, Speijer D, van der Ende A, Neisseria meningitidis Uses Sibling Small Regulatory RNAs To Switch from Cataplerotic to Anaplerotic Metabolism. MBIO 2017;8 (2):e02293-16 [PubMed]
van de Beek D, Brouwer MC, 2016, the year of Zika virus. NAT REV NEUROL 2017;13 (2):69-70 [PubMed]
van de Beek D, Brouwer MC, Neurological infections in 2016: Zika and the rest. LANCET NEUROL 2017;16 (1):17-18 [PubMed]
van Ettekoven CN, van de Beek D, Brouwer MC, Update on community-acquired bacterial meningitis: guidance and challenges. CLIN MICROBIOL INFEC 2017;23 (9):601-606 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in alcoholic patients: A population-based prospective study. J INFECTION 2017;74 (4):352-357 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial Meningitis in Patients using Immunosuppressive Medication: a Population-based Prospective Nationwide Study. J NEUROIMMUNE PHARM 2017;12 (2):213-218 [PubMed]
Voortman M, Fritz D, Vogels OJM, Eftimov F, van de Beek D, Brouwer MC, Drent M, Small fiber neuropathy: a disabling and underrecognized syndrome. CURR OPIN PULM MED 2017;23 (5):447-457 [PubMed]
Zonneveld TP, Nederkoorn PJ, Westendorp WF, Brouwer MC, van de Beek D, Kruyt ND [Contributors: Vermeij JD, Zock E, Hooijenga IJ, Kerkhoff H, Kleyweg RP, Kwa VIH, Bosboom JLW, Weisfelt M, Remmers MJM, van Dijk EJ, Vermeij FH, Schreuder AHCML, Vermeer SE, ten Houten R, Dippel DWJ, Kappelle LJ, van der Worp HB, Merkies ISJ, de Bruijn SFTM, de Laat KF, Jellema K, Keizer K, de Rijk MC, Vermeij AJ, Visser MC, Aerden LAM, Schut ES, Reichman LJA, de Gans K, van den Berg-Vos RM, van Goor MPJ, Wijnhoud AD, van der Ree TC, Janmaat M, van Orshoven NP, Manschot SM]] , Hyperglycemia predicts poststroke infections in acute ischemic stroke. NEUROLOGY 2017;88 (15):1415-1421 [PubMed]
Bijlsma MW. Bacterial meningitis: epidemiology, herd protection, clinical characteristics, and risk assessment. S.l.: s.n.; 2016. 173p. ISBN 978-94-6299-365- [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): van der Ende A, Brouwer MC)
Bijlsma MW, Brouwer MC, Bossuyt PM, Heymans MW, van der Ende A, Tanck MWT, van de Beek D, Risk scores for outcome in bacterial meningitis: Systematic review and external validation study. J INFECTION 2016;73 (5):393-401 [PubMed]
Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D, Community-acquired bacterial meningitis in adults in the Netherlands, 2006-14: a prospective cohort study. LANCET INFECT DIS 2016;16 (3):339-347 [PubMed]
Brouwer MC, Wijdicks EFM, van de Beek D, What's new in bacterial meningitis. INTENS CARE MED 2016;42 (3):415-417 [PubMed]
Costerus JM , Brouwer MC, Bijlsma MW, Tanck MW, van der Ende A, van de Beek D, Impact of an evidence-based guideline on the management of community-acquired bacterial meningitis: a prospective cohort study. CLIN MICROBIOL INFEC 2016;22 (11):928-933 [PubMed]
Costerus JM , Brouwer MC, van der Ende A, van de Beek D, Repeat lumbar puncture in adults with bacterial meningitis. CLIN MICROBIOL INFEC 2016;22 (5):428-433 [PubMed]
Costerus JM, Brouwer MC, van der Ende A, van de Beek D, Community-acquired bacterial meningitis in adults with cancer or a history of cancer. NEUROLOGY 2016;86 (9):860-866 [PubMed]
Cotlarciuc I, Marjot T, Khan MS, Hiltunen S, Haapaniemi E, Metso TM, Putaala J, Zuurbier SM, Brouwer MC, Passamonti SM, Bucciarelli P, Pappalardo E, Patel T, Costa P, Colombi M, Canhão P, Tkach A, Santacroce R, Margaglione M, Favuzzi G, Grandone E, Colaizzo D, Spengos K, Arauz A, Hodge A, Ditta R, Debette S, Zedde M, Pare G, Ferro JM, Thijs V, Pezzini A, Majersik JJ, Martinelli I, Coutinho JM, Tatlisumak T, Sharma P, Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol. BMJ OPEN 2016;6 (11):e012351 [PubMed]
Dias SP, Brouwer MC, Bijlsma MW, van der Ende A, van de Beek D, Sex-based differences in pneumococcal serotype distribution in adults with pneumococcal meningitis. J INFECTION 2016;73 (6):616-619 [PubMed]
Duitman J, Valls Serón M, Engelen-Lee J, Brouwer MC, Spek CA, van de Beek D, Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection. BMC INFECT DIS 2016;16 (1):670 [PubMed]
Engelen-Lee JY, Brouwer MC, Aronica E, van de Beek D, Pneumococcal meningitis: Clinical-pathological correlations (meningene-path). ACTA NEUROPATHOL COM 2016;4 (1):26 [PubMed]
Ferwerda B, Valls Serón M, Jongejan A, Zwinderman AH, Geldhoff M, van der Ende A, Baas F, Brouwer MC, van de Beek D, Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome. EBIOMEDICINE 2016;10:77-84 [PubMed]
Fritz D, van de Beek D, Brouwer MC, Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis. BMC NEUROL 2016;16 (1):220 [PubMed]
Geldhoff M. Pathophysiology of pneumococcal meningitis. S.l.: s.n.; 2016. 215p. ISBN 978-94-6332-062-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D, van der Poll T; copromotor(s): Brouwer MC)
Jim KK, Engelen-Lee J, van der Sar AM, Bitter W, Brouwer MC, van der Ende A, Veening JW, van de Beek D, Vandenbroucke-Grauls CMJE, Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model. J NEUROINFLAMM 2016;13 (1):188 [PubMed]
Kloek AT, van Setten J, van der Ende A, Bots ML, Asselbergs FW, Valls Serón M, Brouwer MC, van de Beek D, Ferwerda B, Exome Array Analysis of Susceptibility to Pneumococcal Meningitis. SCI REP-UK 2016;6:29351 [PubMed]
Leonhard SE, Fritz D, Eftimov F, van der Kooi AJ, van de Beek D, Brouwer MC, Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study. MEDICINE 2016;95 (14):e3277 [PubMed]
Leonhard SE, Fritz D, van de Beek D, Brouwer MC, Cryptococcal meningitis complicating sarcoidosis. MEDICINE 2016;95 (35):e4587 [PubMed]
Lucas MJ. Complications and outcome of bacterial meningitis. S.l.: s.n.; 2016. 159p. ISBN 978-94-6332-024-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): Brouwer MC)
Lucas MJ, Brouwer MC, van de Beek D, Neurological sequelae of bacterial meningitis. J INFECTION 2016;73 (1):18-27 [PubMed]
Pagliano P, Brouwer MC, Comment: "Implementation of a Meningitis Care Bundle in the Emergency Room Reduces Mortality Associated With Acute Bacterial Meningitis". ANN PHARMACOTHER 2016;50 (2):152 [PubMed]
Savva A, Brouwer MC, Roger T, Valls Serón M, le Roy D, Ferwerda B, van der Ende A, Bochud PY, van de Beek D, Calandra T, Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis. P NATL ACAD SCI USA 2016;113 (13):3597-3602 [PubMed]
Valls Serón M, Ferwerda B, Engelen-Lee J, Geldhoff M, Jaspers V, Zwinderman AH, Tanck MW, Baas F, van der Ende A, Brouwer MC, van de Beek D, V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. ACTA NEUROPATHOL COM 2016;4 (1):50 [PubMed]
van de Beek D, Brouwer M, Hasbun R, Koedel U, Whitney CG, Wijdicks E, Community-acquired bacterial meningitis. NAT REV DIS PRIMERS 2016;2:16074 [PubMed]
van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, Leib SL, Mourvillier B, Ostergaard C, Pagliano P, Pfister HW, Read RC, Sipahi OR, Brouwer MC, ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. CLIN MICROBIOL INFEC 2016;22 (Suppl. 3):S37-S62 [PubMed]
van Samkar A. Zoonotic bacterial meningitis in adults: clinical characteristics, etiology, treatment and outcome. S.l.: s.n.; 2016. 151p. ISBN 978-94-6332-068-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): Brouwer MC, van der Ende A)
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D, Capnocytophaga canimorsus Meningitis: Three Cases and a Review of the Literature. ZOONOSES PUBLIC HLTH 2016;63 (6):442-448 [PubMed]
van Samkar A, Brouwer MC, van der Ende A, van de Beek D, Campylobacter Fetus Meningitis in Adults: Report of 2 Cases and Review of the Literature. MEDICINE 2016;95 (8):e2858 [PubMed]
van Samkar A, Brouwer MC, van der Ende A, van de Beek D, Streptococcus equi meningitis. CLIN MICROBIOL INFEC 2016;22 (1):e3-e4 [PubMed]
van Samkar A, Brouwer MC, van der Ende A, van de Beek D, Zoonotic bacterial meningitis in human adults. NEUROLOGY 2016;87 (11):1171-1179 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in diabetes patients: a population-based prospective study. SCI REP-UK 2016;6:36996 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in hematopoietic stem cell transplant recipients: a population-based prospective study. BONE MARROW TRANSPL 2016;51 (11):1490-1495 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in patients with HIV: A population-based prospective study. J INFECTION 2016;72 (3):362-368 [PubMed]
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in solid organ transplant recipients: a population-based prospective study. TRANSPL INFECT DIS 2016;18 (5):674-680 [PubMed]
Vermeij JD, Westendorp WF, Roos YB, Brouwer MC, van de Beek D, Nederkoorn PJ, Preventive Ceftriaxone in Patients with Stroke Treated with Intravenous Thrombolysis: Post Hoc Analysis of the Preventive Antibiotics in Stroke Study. CEREBROVASC DIS 2016;42 (5-6):361-369 [PubMed]
Westendorp WF, Vermeij JD, Brouwer MC, Roos YBWEM, Nederkoorn PJ, van de Beek D, Pre-Stroke Use of Beta-Blockers Does Not Lower Post-Stroke Infection Rate: An Exploratory Analysis of the Preventive Antibiotics in Stroke Study. CEREBROVASC DIS 2016;42 (5-6):506-511 [PubMed]
Adriani KS. Risk factors for community-acquired bacterial meningitis in adults. S.l.: s.n.; 2015. 136p. ISBN 978-94-90791-37-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): Brouwer MC)
Adriani KS, Brouwer MC, van de Beek D, Risk factors for community-acquired bacterial meningitis in adults. NETH J MED 2015;73 (2):53-60 [PubMed]
Brouwer MC, McIntyre P, Prasad K, van de Beek D, Corticosteroids for acute bacterial meningitis. COCHRANE DB SYST REV 2015;2015 (9):CD004405 [PubMed]
Brouwer MC, van de Beek D, Earlier Treatment and Improved Outcome in Adult Bacterial Meningitis Following Guideline Revision Promoting Prompt Lumbar Puncture. CLIN INFECT DIS 2015;61 (4):664-665 [PubMed]
Coumou J, Herkes EA, Brouwer MC, van de Beek D, Tas SW, Casteelen G , van Vugt M, Starink MV, de Vries HJC, de Wever B, Spanjaard L, Hovius JWR, Ticking the right boxes: classification of patients suspected of Lyme borreliosis at an academic referral center in the Netherlands. CLIN MICROBIOL INFEC 2015;21 (4):368.e11-368.e20 [PubMed]
Kasanmoentalib ES, Valls Seron M , Morgan BP, Brouwer MC, van de Beek D, Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a randomized controlled trial. J NEUROINFLAMM 2015;12 (1):149 [PubMed]
Lucas MJ, Brouwer MC, Bovenkerk S, Man WK, van der Ende A, van de Beek D, Group A Streptococcal meningitis in adults. J INFECTION 2015;71 (1):37-42 [PubMed]
Mook BB. Translational studies in pneumococcal meningitis. S.l.: s.n.; 2015. 188p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van de Beek D; copromotor(s): Brouwer MC)
Mook-Kanamori BB, Valls Serón M, Geldhoff M, Havik SR, van der Ende A, Baas F, van der Poll T, Meijers JCM, P Morgan B, Brouwer MC, van de Beek D, Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis. J THROMB HAEMOST 2015;13 (11):2076-2086 [PubMed]
Valls Serón M, Duitman J, Geldhoff M, Engelen-Lee J, Havik SR, Brouwer MC, van de Beek D, Spek CA, CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis. J NEUROINFLAMM 2015;12 (1):88 [PubMed]
van de Beek D, Brouwer M, Nederkoorn P, Parenteral antibiotics are not enough to prevent pneumonia in stroke - Authors' reply. LANCET 2015;386 (9994):653-654 [PubMed]
van Samkar A, Brouwer MC, Pannekoek Y, van der Ende A, van de Beek D, Streptococcus gallolyticus meningitis in adults: report of five cases and review of the literature. CLIN MICROBIOL INFEC 2015;21 (12):1077-1083 [PubMed]
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D, Streptococcus suis Meningitis: A Systematic Review and Meta-analysis. PLOS NEGLECT TROP D 2015;9 (10):e0004191 [PubMed]
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D, Streptococcus suis meningitis in the Netherlands. J INFECTION 2015;71 (5):602-604 [PubMed]
van Samkar A, van de Beek D, Stijnis C, Goris M, Brouwer MC, Suspected leptospiral meningitis in adults: report of four cases and review of the literature. NETH J MED 2015;73 (10):464-470 [PubMed]
Westendorp WF, Vermeij JD, Zock E, Hooijenga IJ, Kruyt ND, Bosboom HJLW, Kwa VIH, Weisfelt M, Remmers MJM, ten Houten R, Schreuder AHCMT, Vermeer SE, van Dijk EJ, Dippel DWJ, Dijkgraaf MGW, Spanjaard L, Vermeulen M, van der Poll T, Prins JM, Vermeij FH, Roos YBWEM, Kleyweg RP, Kerkhoff H, Brouwer MC, Zwinderman AH, van de Beek D, Nederkoorn PJ [Contributors: van de Beek D, Nederkoorn PJ, Westendorp WF , Vermeij JD, Kerkhoff H, Zock E, Kleyweg RP, Bosboom JLW, Kwa VIH, Weisfelt M, Kruyt ND, Remmers MJM, van Dijk EJ, Vermeij F, Schreuder A, Vermeer SE, ten Houten R, Dippel DWJ, Kappelle LJ, van der Worp HB, Merkies ISJ, de Bruijn SFTM, de Laat KF, Haag D, Jellema K, Keizer K, de Rijk MC, Vermeij AJ, Visser MC, Aerden LAM, Schut ES, Reichman LJA, de Gans K, van den Berg-Vos RM, van Goor MPJ, Wijnhoud AD, van der Ree TC, Janmaat M, van Orshoven N, Manschot SM, Dijkgraaf MGW, van der Poll T, Prins JM, Spanjaard L, Vermeij FH]] , The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial. LANCET 2015;385 (9977):1519-1526 [PubMed]
Bijlsma MW, Bekker V, Brouwer MC, Spanjaard L, van de Beek D, van der Ende A, Epidemiology of invasive meningococcal disease in the Netherlands, 1960-2012: an analysis of national surveillance data. LANCET INFECT DIS 2014;14 (9):805-812 [PubMed]
Bijlsma MW, Brouwer MC, Spanjaard L, van de Beek D, van der Ende A, A decade of herd protection after introduction of meningococcal serogroup C conjugate vaccination. CLIN INFECT DIS 2014;59 (9):1216-1221 [PubMed]
Bijlsma MW, Brouwer MC, van den Kerkhof H, Knol MJ, van de Beek D, van der Ende A, No evidence of clusters of serogroup C meningococcal disease in the Dutch MSM community. J INFECTION 2014;68 (3):296-297 [PubMed]
Brouwer MC, Coutinho JM, van de Beek D, Clinical characteristics and outcome of brain abscess Systematic review and meta-analysis. NEUROLOGY 2014;82 (9):806-813 [PubMed]
Brouwer MC, Meijers JCM, Baas F, van der Ende A, Pfister HW, Giese A, van de Beek D, Koedel U, Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. ACTA NEUROPATHOL 2014;127 (4):553-564 [PubMed]
Brouwer MC, Tunkel AR, McKhann GM 2nd, van de Beek D, Brain Abscess. NEW ENGL J MED 2014;371 (5):447-456 [PubMed]
Brouwer MC, Tunkel AR, van de Beek D, Brain abscess. NEW ENGL J MED 2014;371 (18):1758 [PubMed]
Brouwer MC, van de Beek D. Bacterial Meningitis in: Farrar J, Hotez J, Junghans T, Kang G, Lallo D, White N, editors. Manson's tropical diseases, 23rd ed. S.l.: Elsevier; 2014. -, p. 361-369
Heckenberg SGB, Brouwer MC, van de Beek D, Bacterial meningitis. HANDB CLIN NEUROL 2014;121:1361-1375 [PubMed]
Klein M, Brouwer MC, Angele B, Geldhoff M, Marquez G, Varona R, Häcker G, Schmetzer H, Häcker H, Hammerschmidt S, van der Ende A, Pfister HW, van de Beek D, Koedel U, Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis. PLOS ONE 2014;9 (4):e93057 [PubMed]
Koopmans MM, Brouwer MC, Geldhoff M, Seron MV, Houben J, van der Ende A, van de Beek D, Cerebrospinal fluid inflammatory markers in patients with Listeria monocytogenes meningitis. BBA CLIN 2014;1:44-51 [PubMed]
Lucas MJ, Brouwer MC, van der Ende A, van de Beek D, Outcome in patients with bacterial meningitis presenting with a minimal Glasgow Coma Scale score. NEUROL NEUROIMMUNOL NEUROINFLAMM 2014;1 (1):e9 [PubMed]
Mook-Kanamori BB, Brouwer MC, Geldhoff M, Ende Avd, van de Beek D, Cerebrospinal fluid complement activation in patients with pneumococcal and meningococcal meningitis. J INFECTION 2014;68 (6):542-547 [PubMed]
Piet JR, Geldhoff M, van Schaik BDC, Brouwer MC, Valls Seron M , Jakobs ME, Schipper K, Pannekoek Y, Zwinderman AH, van der Poll T, van Kampen AHC, Baas F, van der Ende A, van de Beek D, Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis. J INFECT DIS 2014;209 (11):1781-1791 [PubMed]
van 't Hof FNG, Kurki MI, Kleinloog R, de Bakker PIW, von Und Zu Fraunberg M, Jääskeläinen JE, Gaál EI, Lehto H, Kivisaari R, Laakso A, Niemelä M, Hernesniemi J, Brouwer MC, van de Beek D, Rinkel GJE, Ruigrok YM, Genetic risk load according to the site of intracranial aneurysms. NEUROLOGY 2014;83 (1):34-39 [PubMed]
Westendorp WF, Vermeij JD, Dippel DWJ, Dijkgraaf MGW, van der Poll T, Prins JM, Vermeij FH, Roos YBWEM, Brouwer MC, Zwinderman AH, van de Beek D, Nederkoorn PJ, Update of the Preventive Antibiotics in Stroke Study (PASS): statistical analysis plan. TRIALS 2014;15 (1):382 [PubMed]
Adriani KS, Brouwer MC, Geldhoff M, Baas F, Zwinderman AH, Paul Morgan B, Harris CL, van der Ende A, van de Beek D, Common polymorphisms in the complement system and susceptiblity to bacterial meningitis. J INFECTION 2013;66 (3):255-262 [PubMed]
Adriani KS, Brouwer MC, van der Ende A, van de Beek D, Bacterial Meningitis in Adults After Splenectomy and Hyposplenic States. MAYO CLIN PROC 2013;88 (6):571-578 [PubMed]
Bijlsma MW, Brouwer MC, van de Beek D, Prognostic risk score for pleocytosis with a negative gram stain: valid but of limited utility in bacterial meningitis patients. MAYO CLIN PROC 2013;88 (4):421 [PubMed]
Boelman CG, Brouwer MC, van de Beek D, Adjunctive dexamethasone in adults with meningococcal meningitis. NEUROLOGY 2013;80 (19):1818-1819 [PubMed]
Brouwer MC, Baas F, van der Ende A, van de Beek D, Genetic variation and cerebrospinal fluid levels of mannose binding lectin in pneumococcal meningitis patients. PLOS ONE 2013;8 (5):e65151 [PubMed]
Brouwer MC, Jim KK, Benschop KS, Wolthers KC, van der Ende A, de Jong MD, van de Beek D, No evidence of viral coinfection in cerebrospinal fluid from patients with community-acquired bacterial meningitis. J INFECT DIS 2013;208 (1):182-184 [PubMed]
Brouwer MC, McIntyre P, Prasad K, van de Beek D, Corticosteroids for acute bacterial meningitis. COCHRANE DB SYST REV 2013;2013 (6):CD004405 [PubMed]
Brouwer MC, van de Beek D, Intensified intravenous rifampicin in tuberculous meningitis. LANCET INFECT DIS 2013;13 (1):2-3 [PubMed]
Geldhoff M, Mook-Kanamori BB, Brouwer MC, Troost D, Leemans JC, Flavell RA, van der Ende A, van der Poll T, van de Beek D, Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis. BMC INFECT DIS 2013;13 (1):358 [PubMed]
Geldhoff M, Mook-Kanamori BB, Brouwer MC, Valls Seron M , Baas F, van der Ende A, van de Beek D, Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis. IMMUNOGENETICS 2013;65 (1):9-16 [PubMed]
Hasbun R, Bijlsma M, Brouwer MC, Khoury N, Hadi CM, van der Ende A, Wootton SH, Salazar L, Hossain MM, Beilke M, van de Beek D, Risk score for identifying adults with CSF pleocytosis and negative CSF Gram stain at low risk for an urgent treatable cause. J INFECTION 2013;67 (2):102-110 [PubMed]
Hovius JWR, de Wever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, Oei A, Knol H, Narasimhan S, Hodiamont CJ, Jahfari S, Pals ST, Horlings HM, Fikrig E, Sprong H, van Oers MHJ, A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. LANCET 2013;382 (9892):658 [PubMed]
Iovino F, Brouwer MC, van de Beek D, Molema G, Bijlsma JJE, Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease. CELL MICROBIOL 2013;15 (6):870-881 [PubMed]
Kasanmoentalib ES, Brouwer MC, van de Beek D, Update on bacterial meningitis: epidemiology, trials and genetic association studies. CURR OPIN NEUROL 2013;26 (3):282-288 [PubMed]
Koopmans MM, Brouwer MC, Bijlsma MW, Bovenkerk S, Keijzers W, van der Ende A, van de Beek D, Listeria monocytogenes sequence type 6 and increased rate of unfavorable outcome in meningitis: epidemiologic cohort study. CLIN INFECT DIS 2013;57 (2):247-253 [PubMed]
Lucas MJ, Brouwer MC, van de Beek D, Delayed cerebral thrombosis in bacterial meningitis: a prospective cohort study. INTENS CARE MED 2013;39 (5):866-871 [PubMed]
Lucas MJ, Brouwer MC, van der Ende A, van de Beek D, Endocarditis in adults with bacterial meningitis. CIRCULATION 2013;127 (20):2056-2062 [PubMed]
Adriani KS, Brouwer MC, Baas F, Zwinderman AH, van der Ende A, van de Beek D, Genetic Variation in the beta 2-Adrenocepter Gene Is Associated with Susceptibility to Bacterial Meningitis in Adults. PLOS ONE 2012;7 (5):e37618 [PubMed]
Adriani KS, Brouwer MC, van der Ende A, van de Beek D, Bacterial meningitis in pregnancy: report of six cases and review of the literature. CLIN MICROBIOL INFEC 2012;18 (4):345-351 [PubMed]
Adriani KS, van de Beek D, Troost D, Brouwer MC, The Diagnostic Pitfall of Infratentorial Subdural Empyema. ARCH NEUROL-CHICAGO 2012;69 (8):1076-1077 [PubMed]
Brouwer MC, Thwaites GE, Tunkel AR, van de Beek D, Dilemmas in the diagnosis of acute community-acquired bacterial meningitis. LANCET 2012;380 (9854):1684-1692 [PubMed]
Brouwer MC, van de Beek D, Bacteriële meningitis. NED TIJDSCHR TANDHEELKD 2012;119 (5):238-242 [PubMed]
Brouwer MC, van der Ende A, Baas F, van de Beek D, Genetic variation in GLCCI1 and dexamethasone in bacterial meningitis. J INFECTION 2012;65 (5):465-467 [PubMed]
Costerus JM, van de Beek D, Brouwer MC, Nosocomial meningitis caused by gas producing Klebsiella pneumoniae. BMJ CASE REP 2012;2012:bcr1120115137 [PubMed]
Fritz D, Brouwer MC, van de Beek D, Dexamethasone and long-term survival in bacterial meningitis. NEUROLOGY 2012;79 (22):2177-2179 [PubMed]
Heckenberg SGB, Brouwer MC, van der Ende A, Hensen EF, van de Beek D, Hearing loss in adults surviving pneumococcal meningitis is associated with otitis and pneumococcal serotype. CLIN MICROBIOL INFEC 2012;18 (9):849-855 [PubMed]
Heckenberg SGB, Brouwer MC, van der Ende A, van de Beek D, Adjunctive dexamethasone in adults with meningococcal meningitis. NEUROLOGY 2012;79 (15):1563-1569 [PubMed]
Jim KK, Brouwer MC, van der Ende A, van de Beek D, Cerebral abscesses in patients with bacterial meningitis. J INFECTION 2012;64 (2):236-238 [PubMed]
Jim KK, Brouwer MC, van der Ende A, van de Beek D, Subdural empyema in bacterial meningitis. NEUROLOGY 2012;79 (21):2133-2139 [PubMed]
Mook-Kanamori BB, Fritz D, Brouwer MC, van der Ende A, van de Beek D, Intracerebral Hemorrhages in Adults with Community Associated Bacterial Meningitis in Adults: Should We Reconsider Anticoagulant Therapy?. PLOS ONE 2012;7 (9):e45271 [PubMed]
Piet JR, Brouwer MC, Exley R, van der Veen S, van de Beek D, van der Ende A, Meningococcal Factor H Binding Protein fHbpd184 Polymorphism Influences Clinical Course of Meningococcal Meningitis. PLOS ONE 2012;7 (10):e47973 [PubMed]
Schut ES, Brouwer MC, Scarborough M, Mai NTH, Thwaites GE, Farrar JJ, Reitsma JB, van de Beek D, Validation of a Dutch Risk Score Predicting Poor Outcome in Adults with Bacterial Meningitis in Vietnam and Malawi. PLOS ONE 2012;7 (3):e34311 [PubMed]
Schut ES, Lucas MJ, Brouwer MC, Vergouwen MDI, van der Ende A, van de Beek D, Cerebral Infarction in Adults with Bacterial Meningitis. NEUROCRIT CARE 2012;16 (3):421-427 [PubMed]
van de Beek D, Brouwer MC, Thwaites GE, Tunkel AR, Advances in treatment of bacterial meningitis. LANCET 2012;380 (9854):1693-1702 [PubMed]
Brouwer MC, Spanjaard L, Prins JM, van der Ley P, van de Beek D, van der Ende A, Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. J INFECTION 2011;62 (6):479-483 [PubMed]
Brouwer MC, van de Beek D, Glycerol in bacterial meningitis: one strike and out?. LANCET INFECT DIS 2011;11 (4):257-258 [PubMed]
Woehrl B, Brouwer MC, Murr C, Heckenberg SGB, Baas F, Pfister HW, Zwinderman AH, Morgan BP, Barnum SR, van der Ende A, Koedel U, van de Beek D, Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J CLIN INVEST 2011;121 (10):3943-3953 [PubMed]
Brouwer MC. Bacterial meningitis in adults: clinical characteristics, risk factors and adjunctive treatment. s.l.: s.n.; 2010. 258p. ISBN 9789090255873 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Vermeulen M; copromotor(s): van de Beek D)
Brouwer MC, Heckenberg SGB, de Gans J, Spanjaard L, Reitsma JB, van de Beek D, Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis. NEUROLOGY 2010;75 (17):1533-1539 [PubMed]
Brouwer MC, Kasanmoentalib ES, Opstelten FWJ, van der Ende A, van de Beek D, A horse bite to remember. LANCET 2010;376 (9747):1194 [PubMed]
Brouwer MC, McIntyre P, de Gans J, Prasad K, van de Beek D, Corticosteroids for acute bacterial meningitis. COCHRANE DB SYST REV 2010;2010 (9):CD004405 [PubMed]
Brouwer MC, Read RC, van de Beek D, Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis. LANCET INFECT DIS 2010;10 (4):262-274 [PubMed]
Brouwer MC, Tunkel AR, van de Beek D, Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis. CLIN MICROBIOL REV 2010;23 (3):467-+ [PubMed]
Brouwer MC, van de Beek D, An agitated man with earache. BMJ-BRIT MED J 2010;341:c3824 [PubMed]
Klein M, Koedel U, Kastenbauer S, Pfister HW, van de Beek D, Schut ES, Brouwer MC, Steiner I, Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis?. NEUROLOGY 2010;75 (2):193; author reply 193-193; author reply 194 [PubMed]
Soemirien Kasanmoentalib E, Brouwer MC, van der Ende A, van de Beek D, Hydrocephalus in adults with community-acquired bacterial meningitis. NEUROLOGY 2010;75 (10):918-923 [PubMed]
van de Beek D, Brouwer MC, No difference between short-course and long-course antibiotics for bacterial meningitis in children, but available evidence limited. EVID BASED MED 2010;15 (1):6-7 [PubMed]
van de Beek D, Brouwer MC, Randomised controlled trial: Hearing loss after bacterial meningitis is predicted by presenting status and young age; effectiveness of adjuvant dexamethasone or glycerol unclear. EVID BASED MED 2010;15 (2):39-40 [PubMed]
Brouwer MC, de Gans J, Heckenberg SGB, Zwinderman AH, van der Poll T, van de Beek D, Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. LANCET INFECT DIS 2009;9 (1):31-44 [PubMed]
Brouwer MC, de Gans J, Willemse RB, van de Beek D, Neurological picture. Sarcoidosis presenting with hydrocephalus. J NEUROL NEUROSUR PS 2009;80 (5):550-551 [PubMed]
Brouwer MC, Keizerweerd GD, de Gans J, Spanjaard L, van de Beek D, Community acquired Staphylococcus aureus meningitis in adults. SCAND J INFECT DIS 2009;41 (5):375-377 [PubMed]
Brouwer MC, van de Beek D, Genetics in meningococcal disease: one step beyond. CLIN INFECT DIS 2009;48 (5):595-597 [PubMed]
Schut ES, Brouwer MC, de Gans J, Florquin S, Troost D, van de Beek D, Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis. NEUROLOGY 2009;73 (23):1988-1995 [PubMed]
Brouwer MC, de Gans J, Heckenberg SGB, Kuiper H, van Lieshout HBM, van de Beek D, Vertebral osteomyelitis complicating pneumococcal meningitis. NEUROLOGY 2008;71 (8):612-613 [PubMed]
Heckenberg SGB, de Gans J, Brouwer MC, Weisfelt M, Piet JR, Spanjaard L, van der Ende A, van de Beek D, Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study. MEDICINE 2008;87 (4):185-192 [PubMed]
Adriani KS, van de Beek D, Brouwer MC, Spanjaard L, de Gans J, Community-acquired recurrent bacterial meningitis in adults. CLIN INFECT DIS 2007;45 (5):e46-e51 [PubMed]
Brouwer MC, van de Beek D, Heckenberg SGB, Spanjaard L, de Gans J, Community-acquired Haemophilus influenzae meningitis in adults. CLIN MICROBIOL INFEC 2007;13 (4):439-442 [PubMed]
Brouwer MC, van de Beek D, Heckenberg SGB, Spanjaard L, de Gans J, Hyponatraemia in adults with community-acquired bacterial meningitis. QJM-INT J MED 2007;100 (1):37-40 [PubMed]
Richard E, Brouwer MC, Portegies P. Primary central nervous system lymphoma in: de Visser M, editor. Handbook of Clinical Neurology. Amsterdam: elsevier; 2007. 85, p. 221-228
van de Beek D, Brouwer M, de Gans J, Hypernatremia in bacterial meningitis. J INFECTION 2007;55 (4):381-382 [PubMed]
Brouwer MC, van de Beek D, Heckenberg SGB, Spanjaard L, de Gans J, Community-acquired Listeria monocytogenes meningitis in adults. CLIN INFECT DIS 2006;43 (10):1233-1238 [PubMed]
Key publications

Woehrl B, Brouwer MC, Murr C, Heckenberg SGB, Baas F, Pfister HW, Zwinderman AH, Morgan BP, Barnum SR, van der Ende A, Koedel U, van de Beek D, Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J CLIN INVEST 2011;121 (10):3943-3953 [PubMed]
Brouwer MC, Meijers JCM, Baas F, van der Ende A, Pfister HW, Giese A, van de Beek D, Koedel U, Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. ACTA NEUROPATHOL 2014;127 (4):553-564 [PubMed]
Brouwer MC, Thwaites GE, Tunkel AR, van de Beek D, Dilemmas in the diagnosis of acute community-acquired bacterial meningitis. LANCET 2012;380 (9854):1684-1692 [PubMed]
Brouwer MC, Tunkel AR, McKhann GM 2nd, van de Beek D, Brain Abscess. NEW ENGL J MED 2014;371 (5):447-456 [PubMed]
van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, Leib SL, Mourvillier B, Ostergaard C, Pagliano P, Pfister HW, Read RC, Sipahi OR, Brouwer MC, ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. CLIN MICROBIOL INFEC 2016;22 (Suppl. 3):S37-S62 [PubMed]


All Publications

Curriculum Vitae

 

EDUCATION
2010 Doctor of Philosophy, University of Amsterdam (UvA).
2010 Board Certification Neurology
2002 Medical Degree, UvA.
2000 Master of Science, Medicine, UvA.
1988-95 Grammar school (V.W.O.), Het Nieuwe Eemland College, Amersfoort.

 

WORK EXPERIENCE
2012- Neurologist, Academic Medical Center (AMC), UvA, Amsterdam.
2011 Research Fellowship Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany.
2010-11 Fellowship Neurological Infectious Diseases, Academic Medical Center (AMC), UvA, Amsterdam.
2003-10 Neurology Resident, AMC, UvA, Amsterdam.
2002 Neurology Resident, Onze Lieve Vrouwe Gasthuis - hospital, Amsterdam.
1998 Polio Vaccination and Sexual Transmitted Diseases Education project in Mpererwe, Uganda; Organized by the International Federation of Medical Students Associations.

 

DISSERTATION
2010 Bacterial meningitis in adults: clinical characteristics, risk factors and adjunctive therapy.

 

RESEARCH PROJECTS
2016  Bacterial blood-brain barrier traversal in pneumococcal meningitis: miniature dimensions of host-pathogen interaction. Amsterdam neuroscience innovation grant.
2013-15 Cerebrovascular complications in bacterial meningitis: from host genetics towards new therapies. Veni project nr. 016.136.078.
2011 The plasminogen system in bacterial meningitis. Cooperative project Department of Neurology, AMC, Amsterdam, the Netherlands and Klinikum Grosshadern, Ludwig-Maximilians University, Munchen, Germany (Prof. Dr. H.W. Pfister, Prof. Dr. U. Koedel).
2006-10 Ph.D. project “Bacterial meningitis in adults: clinical characteristics, risk factors and adjunctive treatment ”. Supervisor: Dr. D. van de Beek, Department of Neurology, AMC.
2000 Research project “Genetic typing of rhabdomyosarcomas and medulloblastomas.” Supervisor: Prof. Dr. F. Baas, Department of Genome Analysis, AMC.
1999 Research project “Induction of single nucleotide mutations in the Preseniline-1 gene by means of circular DNA/RNA fragments”. Supervisor: Prof. Dr. S. Krauss, Department of Molecular Genetics University of Tromsø, Norway.

 

GRANTS / SCHOLARSHIPS 
2016 Amsterdam neuroscience innovation grant for blood-brain barrier model set-up
2014 AMC  innovation project "Optimalisation and centralisation of multidisciplinary care for neurosarcoidosis patients"
2014 AMC-VuMC PhD student project 
2013 ESCMID guideline preparation grant 
2012 ZonMw Veni Grant 
2011 BBMRI-NL Complementation Project Grant (shared PI-ship)
2011 EFNS Scientific Fellowship Grant
2011 ESCMID Research Grant 
1999 EU Erasmus Grant

 

PRIZES
2011 VIZ O’Callaghan Award. Award of Dutch Society for Infectious Diseases for best thesis 2009-2010. 
2011 ICAAC Program Committee Award. The ICAAC Program Committee Awards are established to encourage and recognize research excellence, through outstanding abstract preparation. Out of 1300 abstracts, 6 are selected that reflect high quality research, conducted with exhaustive data analysis, and of major importance to the field. 
2011 AMC Excellent Thesis Award. Award for 2nd best thesis in the AMC 2010.
2010 Scientific Meeting Presentation Award Dutch Neurological Society (NVN). 
2009 IDSA International Young Investigator Award. Awards are given to young investigators who submit excellent research to the IDSA annual meeting.

 

OTHER
2016 Section editor current opinion in infectious diseases
2014 Associate editor Neurology: Neuroimmunology and neuroinflammation
2011 Member Childhood Life-threatening Infectious Disease Study (EUCLIDS) FP7 projec (Prof. Dr. M. Levin, Imperial College London, UK)
2010 Associate Editor Faculty of 1000
2010 Member European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Study Group on Infection of the Brain (ESGIB; Prof. Dr. S.L. Leib, University of Bern, Switzerland)

 

Research programmes

Prof. D. van de Beek MD PhD (Neuroinfection and Inflammation)

Other research related activities
  • Contribution to guidelines and protocols, Bacterial meningitis - Nederlandse vereniging voor neurologie
  • Contribution to guidelines and protocols, Bacterial meningitis - SWAB
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • ZonMw