• Female

Dr. A.M.G. van der Aar

Position: Postdoc
Main activities: Research
Specialisation: Dendritic cells and HIV
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Focus of research:

Our research focuses on the different signaling pathways that HIV-1 subverts in DCs for integration and replication. Identification of the mechanisms required for HIV-1 infection can identify novel targets to prevent HIV-1 dissemination.

 

 

AMC themes: Infection & Immunity
Departments: Center of Experimental and Molecular Medicine
Hertoghs N, van der Aar AMG, Setiawan LC, Kootstra NA, Gringhuis SI, Geijtenbeek TBH, SAMHD1 degradation enhances active suppression of dendritic cell maturation by HIV-1. J IMMUNOL 2015;194 (9):4431-4437 [PubMed]
van den Berg LM, Cardinaud S, van der Aar AMG, Sprokholt JK, de Jong MAWP, Zijlstra-Willems EM, Moris A, Geijtenbeek TBH, Langerhans Cell-Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1. J IMMUNOL 2015;195 (4):1763-1773 [PubMed]
van der Aar AMG, Picavet DI, Muller FJ, de Boer L, van Capel TMM, Zaat SAJ, Bos JD, Janssen H, George TC, Kapsenberg ML, van Ham SM, Teunissen MBM, de Jong EC, Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J INVEST DERMATOL 2013;133 (5):1240-1249 [PubMed]
van der Aar AMG, de Groot R, Sanchez-Hernandez M, Taanman EWM, van Lier RAW, Teunissen MBM, de Jong EC, Kapsenberg ML, Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8(+) T Cell Responses. J IMMUNOL 2011;187 (7):3488-3492 [PubMed]
van der Aar AMG, Sibiryak DS, Bakdash G, van Capel TMM, van der Kleij HPM, Opstelten DJE, Teunissen MBM, Kapsenberg ML, de Jong EC, Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells. J ALLERGY CLIN IMMUN 2011;127 (6):1532-U334 [PubMed]
van der Vlist M, van der Aar AMG, Gringhuis SI, Geijtenbeek TBH, Innate signaling in HIV-1 infection of dendritic cells. CURR OPIN HIV AIDS 2011;6 (5):348-352 [PubMed]
van der Aar AMG. Functional specialization of human skin dendritic cell subsets in immunity to different slasses of pathogens. s.l.: s.n.; 2010. 160p. ISBN 9789490371104 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bos JD, Kapsenberg ML; copromotor(s): Teunissen MBM, de Jong EC)
Lebre MC, van der Aar AMG, van Baarsen L, van Capel TMM, Schuitemaker JHN, Kapsenberg ML, de Jong EC, Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J INVEST DERMATOL 2007;127 (2):331-341 [PubMed]
van der Aar AMG, Sylva-Steenland RMR, Bos JD, Kapsenberg ML, de Jong EC, Teunissen MBM, Cutting edge: Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition. J IMMUNOL 2007;178 (4):1986-1990 [PubMed]
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