• Male

Dr. G.J.J. Boink

Position: PhD student
Main activities: Patient care, Research
Specialisation: Clinical & Experimental Cardiology
foto
Focus of research:

Cardiac Electrophysiology

AMC themes: Cardiovascular Diseases
Departments: Cardiology
Driessen HE, Boink GJJ, van Veen TAB, miRNA-based antiarrhythmics after myocardial ischaemic injury. EUROPACE 2017;ahead of print [PubMed]
Driessen HE, van Veen TAB, Boink GJJ, Emerging molecular therapies targeting myocardial infarction-related arrhythmias. EUROPACE 2017;19 (4):518-528 [PubMed]
Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans MJHT, Boink GJJ, Coronel R, Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms. FRONT PHYSIOL 2017;8:797 [PubMed]
Kiemeneij F, Boink GJJ, The PROPHET-II's Prophecy. JACC-CARDIOVASC INTE 2016;9 (19):2000-2001 [PubMed]
Woudstra OI, Boink GJJ, Winkelman JA, van Stralen R, A Rare Case of Primary Meningococcal Myopericarditis in a 71-Year-Old Male. CASE REP CARDIOL 2016;2016:1297869 [PubMed]
Boink GJJ, Christoffels VM, Robinson RB, Tan HL, The past, present, and future of pacemaker therapies. TRENDS CARDIOVAS MED 2015;25 (8):661-673 [PubMed]
Boink GJJ, Robinson RB, Gene therapy for restoring heart rhythm. J CARDIOVASC PHARM T 2014;19 (5):426-438 [PubMed]
Costet A, Provost J, Gambhir A, Bobkov Y, Danilo P Jr, Boink GJJ, Rosen MR, Konofagou EE, Electromechanical Wave Imaging of Biologically and Electrically Paced Canine Hearts in Vivo. ULTRASOUND MED BIOL 2014;40 (1):177-187 [PubMed]
Boink GJJ. Molecular therapies for cardiac arrhythmias. s.l.: s.n.; 2013. 378p. ISBN 9789461823083 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de Bakker JMT, Rosen MR; copromotor(s): Tan HL)
Boink GJJ, Duan L, Nearing BD, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Bobkov E, Kryukova Y, Ozgen N, Danilo P Jr, Cohen IS, Verrier RL, Robinson RB, Rosen MR, HCN2/SkM1 Gene Transfer Into Canine Left Bundle Branch Induces Stable, Autonomically Responsive Biological Pacing at Physiological Heart Rates. J AM COLL CARDIOL 2013;61 (11):1192-1201 [PubMed]
den Haan AD, Veldkamp MW, Bakker D, Boink GJJ, Janssen RB, de Bakker JMT, Tan HL, Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy. PLOS ONE 2013;8 (3):e59290 [PubMed]
Xiao L, Koopmann TT, Ördög B, Postema PG, Verkerk AO, Iyer V, Sampson KJ, Boink GJJ, Mamarbachi MA, Varro A, Jordaens L, Res J, Kass RS, Wilde AA, Bezzina CR, Nattel S, Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation. CIRC RES 2013;112 (10):1310-1322 [PubMed]
Bakker ML, Boink GJJ, Boukens BJ, Verkerk AO, van den Boogaard M, Den Haan AD, Hoogaars WMH, Buermans HP, de Bakker JMT, Seppen J, Tan HL, Moorman AFM, 't Hoen PAC, Christoffels VM, T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells. CARDIOVASC RES 2012;94 (3):439-449 [PubMed]
Boink GJJ, Lau DH, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Driessen HE, Dun W, Chen M, Danilo P Jr, Rosen TS, Őzgen N, Duffy HS, Kryukova Y, Boyden PA, Robinson RB, Brink PR, Cohen IS, Rosen MR, SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic. CARDIOVASC RES 2012;94 (3):450-459 [PubMed]
Boink GJJ, Lu J, Driessen HE, Duan L, Sosunov EA, Anyukhovsky EP, Shlapakova IN, Lau DH, Rosen TS, Danilo P, Jia Z, Ozgen N, Bobkov Y, Guo Y, Brink PR, Kryukova Y, Robinson RB, Entcheva E, Cohen IS, Rosen MR, Effect of Skeletal Muscle Na+ Channel Delivered Via a Cell Platform on Cardiac Conduction and Arrhythmia Induction. CIRC-ARRHYTHMIA ELEC 2012;5 (4):831-840 [PubMed]
Boink GJJ, Nearing BD, Shlapakova IN, Duan L, Kryukova Y, Bobkov Y, Tan HL, Cohen IS, Danilo P Jr, Robinson RB, Verrier RL, Rosen MR, Ca2+-Stimulated Adenylyl Cyclase AC1 Generates Efficient Biological Pacing as Single Gene Therapy and in Combination With HCN2. CIRCULATION 2012;126 (5):528-+ [PubMed]
Boink GJJ, Rosen MR. Developing biological pacemakers - where we stand and what is next. in: Mann DL, Bonow RO, Zipes DP, Libby P, editors. Braunwald's Heart Disease. S.l.: Elsevier Health Sciences Division; 2012. 9th ed., p. on-line content
Lu J, Wang HZ, Jia Z, Zuckerman J, Lu Z, Guo Y, Boink GJJ, Brink PR, Robinson RB, Entcheva E, Cohen IS, Improving Cardiac Conduction With a Skeletal Muscle Sodium Channel by Gene and Cell Therapy. J CARDIOVASC PHARM 2012;60 (1):88-99 [PubMed]
Özgen N, Lu Z, Boink GJJ, Lau DH, Shlapakova IN, Bobkov Y, Danilo P Jr, Cohen IS, Rosen MR, Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing. HEART RHYTHM 2012;9 (11):1865-1872 [PubMed]
Amin AS, Boink GJJ, Atrafi F, Spanjaart AM, Asghari-Roodsari A, Molenaar RJ, Ruijter JM, Wilde AAM, Tan HL, Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome. EUROPACE 2011;13 (7):968-975 [PubMed]
Boink GJJ, Rosen MR, Regenerative therapies in electrophysiology and pacing: introducing the next steps. J INTERV CARD ELECTR 2011;31 (1):3-16 [PubMed]
Shlapakova IN, Nearing BD, Lau DH, Boink GJJ, Danilo P Jr, Kryukova Y, Robinson RB, Cohen IS, Rosen MR, Verrier RL, Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal. HEART RHYTHM 2010;7 (12):1835-1840 [PubMed]
Boink GJJ, Verkerk AO, van Amersfoorth SCM, Tasseron SJ, van der Rijt R, Bakker D, Linnenbank AC, van der Meulen J , de Bakker JMT, Seppen J, Tan HL, Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer. J GENE MED 2008;10 (5):487-497 [PubMed]
Boink GJJ, Seppen J, de Bakker JMT, Tan HL, Biological pacing by gene and cell therapy. NETH HEART J 2007;15 (9):318-322 [PubMed]
Boink GJJ, Seppen J, de Bakker JMT, Tan HL. Gene therapy to create biological pacemakers in: Spaan JAE, Coronel R, de Bakker JMT, Zaza A, editors. Biopacemaking. Berlin-Heidelberg: Springer Verlag; 2007., p. 79-93
Boink GJJ, Seppen J, de Bakker JMT, Tan HL, Gene therapy to create biological pacemakers. MED BIOL ENG COMPUT 2007;45 (2):167-176 [PubMed]
Schalekamp T, Boink GJJ, Visser LE, Stricker BHC, de Boer A, Klungel OH, CYP2C9 genotyping in acenocoumarol treatment: is it a cost-effective addition to international normalized ratio monitoring?. CLIN PHARMACOL THER 2006;79 (6):511-520 [PubMed]
Key publications

Boink GJJ, Rosen MR, Regenerative therapies in electrophysiology and pacing: introducing the next steps. J INTERV CARD ELECTR 2011;31 (1):3-16 [PubMed]
Shlapakova IN, Nearing BD, Lau DH, Boink GJJ, Danilo P Jr, Kryukova Y, Robinson RB, Cohen IS, Rosen MR, Verrier RL, Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal. HEART RHYTHM 2010;7 (12):1835-1840 [PubMed]
Boink GJJ, Verkerk AO, van Amersfoorth SCM, Tasseron SJ, van der Rijt R, Bakker D, Linnenbank AC, van der Meulen J , de Bakker JMT, Seppen J, Tan HL, Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer. J GENE MED 2008;10 (5):487-497 [PubMed]
Schalekamp T, Boink GJJ, Visser LE, Stricker BHC, de Boer A, Klungel OH, CYP2C9 genotyping in acenocoumarol treatment: is it a cost-effective addition to international normalized ratio monitoring?. CLIN PHARMACOL THER 2006;79 (6):511-520 [PubMed]


All Publications

Research programmes

Dr. H.L. Tan (Sudden cardiac death Applying lessons from monogenic inherited arrhythmia syndromes to develop new gene-oriented treatment strategies)

Other research related activities
  • None reported
Current research funding
  • AMC
  • Europese Unie
  • Medtronic Bakken Research Center BV
  • Nederlandse Hartstichting
  • Technologiestichting STW
  • ZonMw