• Principal Investigator
  • Female

Prof. dr. K.K. Krishnadath

Position: Professor
Main activities: Patient care, Research
Specialisation: Staff member Gastroenterolgy Hepatology, PI Gastrointestinal Oncology Research Group
foto K.K. Krishnadath is one of the AMC Principal Investigators
Focus of research:
  • Barrett's esophagus
  • Esophageal adenocarcinoma
  • Translational Gastroenterology, oncology studies
  • Biomarkers
  • pathogenesis of metaplasia
  • Models
AMC themes: Metabolic disorders and gastrointestinal diseases, Oncology
Departments: Center of Experimental and Molecular Medicine, Gastroenterology and Hepatology
Duits LC, van der Wel MJ, Cotton CC, Phoa KN, ten Kate FJW, Seldenrijk CA, Offerhaus GJA, Visser M , Meijer SL, Mallant-Hent RC, Krishnadath KK, Pouw RE, Tijssen JGP, Shaheen NJ, Bergman JJGHM, Patients With Barrett's Esophagus and Confirmed Persistent Low-Grade Dysplasia Are at Increased Risk for Progression to Neoplasia. GASTROENTEROLOGY 2017;152 (5):993-1001.e1 [PubMed]
Ebbing EA, Steins A, Fessler E, Stathi P, Lesterhuis WJ, Krishnadath KK, Vermeulen L, Medema JP, Bijlsma MF, van Laarhoven HWM, Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition. GASTROENTEROLOGY 2017;153 (1):63-76.e14 [PubMed]
Mari L. Barrett’s esophagus and esophageal adenocarcinoma: from molecular pathogenesis to novel therapeutic targets. S.l.: s.n.; 2017. 227p. ISBN 978-94-6295-710-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Krishnadath KK, Fockens P; copromotor(s): Calpe S)
Weijenborg PW, Smout AJPM, Krishnadath KK, Bergman JGHM, Verheij J, Bredenoord AJ, Esophageal sensitivity to acid in patients with Barrett's esophagus is not related to preserved esophageal mucosal integrity. NEUROGASTROENT MOTIL 2017;29 (7):e13066 [PubMed]
Calpe S, Correia ACP, Sancho-Serra MDC, Krishnadath KK, Comparison of newly developed anti-bone morphogenetic protein 4 llama-derived antibodies with commercially available BMP4 inhibitors. MABS-AUSTIN 2016;8 (4):678-688 [PubMed]
Ebbing EA, Medema JP, Damhofer H, Meijer SL, Krishnadath KK, van Berge Henegouwen MI, Bijlsma MF, van Laarhoven HWM, ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3. ONCOTARGET 2016;7 (9):10243-10254 [PubMed]
Liu DS, Hoefnagel SJM, Fisher OM, Krishnadath KK, Montgomery KG, Busuttil RA, Colebatch AJ, Read M, Duong CP, Phillips WA, Clemons NJ, Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis. ONCOTARGET 2016;7 (50):83342-83358 [PubMed]
Martinez P, Timmer MR, Lau CT, Calpe S, Sancho-Serra MDC, Straub D, Baker AM, Meijer SL, ten Kate FJW, Mallant-Hent RC, Naber AHJ, van Oijen AHAM, Baak LC, Scholten P, Böhmer CJM, Fockens P, Bergman JJGHM, Maley CC, Graham TA, Krishnadath KK, Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus. NAT COMMUN 2016;7:12158 [PubMed]
Timmer M. Biomarkers in premalignant conditions of the gastrointestinal tract: Studies on Barrett’s esophagus and primary sclerosing cholangitis. S.l.: s.n.; 2016. 201p. ISBN 978-94-6182-732-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Krishnadath KK, Fockens P; copromotor(s): Wang KK, Calpe S)
Timmer MR, Lau CT, Meijer SL, Fockens P, Rauws EAJ, Ponsioen CY, Calpe S, Krishnadath KK, Genetic Abnormalities in Biliary Brush Samples for Distinguishing Cholangiocarcinoma from Benign Strictures in Primary Sclerosing Cholangitis. GASTROENT RES PRACT 2016;2016:4381513 [PubMed]
Timmer MR, Martinez P, Lau CT, Westra WM, Calpe S, Rygiel AM, Rosmolen WD, Meijer SL, ten Kate FJW, Dijkgraaf MGW, Mallant-Hent RC, Naber AHJ, van Oijen AHAM, Baak LC, Scholten P, Böhmer CJM, Fockens P, Maley CC, Graham TA, Bergman JJGHM, Krishnadath KK, Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study. GUT 2016;65 (10):1602-1610 [PubMed]
Bennett C, Moayyedi P, Corley DA, Decaestecker J, Falck-Ytter Y, Falk G, Vakil N, Sanders S, Vieth M, Inadomi J, Aldulaimi D, Ho KY, Odze R, Meltzer SJ, Quigley E, Gittens S, Watson P, Zaninotto G, Iyer PG, Alexandre L, Ang Y, Callaghan J, Harrison R, Singh R, Bhandari P, Bisschops R, Geramizadeh B, Kaye P, Krishnadath S, Fennerty MB, Manner H, Nason KS, Pech O, Konda V, Ragunath K, Rahman I, Romero Y, Sampliner R, Siersema PD, Tack J, Tham TCK, Trudgill N, Weinberg DS, Wang J, Wang K, Wong JYY, Attwood S, Malfertheiner P, MacDonald D, Barr H, Ferguson MK, Jankowski J, BOB CAT: a Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia. AM J GASTROENTEROL 2015;110 (5):662-82; quiz 683 [PubMed]
Calpe S, Wagner K, El Khattabi M, Rutten L, Zimberlin C, Dolk E, Verrips CT, Medema JP, Spits H, Krishnadath KK, Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies. MOL CANCER THER 2015;14 (11):2527-2540 [PubMed]
Damhofer H, Ebbing EA, Steins A, Welling L, Tol JA, Krishnadath KK, van Leusden T, van de Vijver MJ, Besselink MG, Busch OR, van Berge Henegouwen MI, van Delden O, Meijer SL, Dijk F, Medema JP, van Laarhoven HW, Bijlsma MF, Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract. J TRANSL MED 2015;13 (1):115 [PubMed]
Davelaar AL, Calpe S, Lau L, Timmer MR, Visser M , ten Kate FJ, Parikh KB, Meijer SL, Bergman JJ, Fockens P, Krishnadath KK, Aberrant TP53 detected by combining immunohistochemistry and DNA-FISH improves Barrett's esophagus progression prediction: a prospective follow-up study. GENE CHROMOSOME CANC 2015;54 (2):82-90 [PubMed]
Davelaar AL, Straub D, Buttar NS, Fockens P, Krishnadath KK, Active matrix metalloproteases are expressed early on and are high during the Barrett's esophagus malignancy sequence. SCAND J GASTROENTERO 2015;50 (3):321-332 [PubMed]
Davelaar AL, Straub D, Parikh KB, Lau L, Fockens P, Krishnadath KK, Increased phosphorylation on residue S795 of the retinoblastoma protein in esophageal adenocarcinoma. INT J ONCOL 2015;47 (2):583-591 [PubMed]
Duits LC, Phoa KN, Curvers WL, ten Kate FJW, Meijer GA, Seldenrijk CA, Offerhaus GJ, Visser M , Meijer SL, Krishnadath KK, Tijssen JGP, Mallant-Hent RC, Bergman JJGHM, Barrett's oesophagus patients with low-grade dysplasia can be accurately risk-stratified after histological review by an expert pathology panel. GUT 2015;64 (5):700-706 [PubMed]
Janmaat VT, van de Winkel A, Peppelenbosch MP, Spaander MCW, Uitterlinden AG, Pourfarzad F, Tilanus HW, Rygiel AM, Moons LMG, Arp PP, Krishnadath KK, Kuipers EJ, van der Laan LJW, Vitamin D Receptor Polymorphisms Are Associated with Reduced Esophageal Vitamin D Receptor Expression and Reduced Esophageal Adenocarcinoma Risk. MOL MED 2015;21:346-354 [PubMed]
Krishnadath KK, Wang KK, Molecular pathogenesis of Barrett esophagus: current evidence. GASTROENTEROL CLIN N 2015;44 (2):233-247 [PubMed]
Noordman BJ, Shapiro J, Spaander MCW, Krishnadath KK, van Laarhoven HWM, van Berge Henegouwen MI, Nieuwenhuijzen GAP, van Hillegersberg R, Sosef MN, Steyerberg EW, Wijnhoven BPL, van Lanschot JJB [Contributors: van Lanschot JJB, Wijnhoven BPL, Noordman BJ, Shapiro J, Biermann K, van der Gaast A, Krak NC, van Rij C, Spaander MCW, Steyerberg EW, Valkema R, Bennink RJ, van Berge Henegouwen MI, Hulshof MCCM, Krishnadath KK, van Laarhoven HWM, Meijer SL, Haj Mohammad N , van Hillegersberg R, Hobbelink MGG, van Leeuwen MS, Offerhaus GJA, Reerink O, Siersema PD, Creemers GJ, Nieuwenhuijzen GAP, Roef MJ, van der Sangen MJC, Schoon EJ, Buijsen J, Nap M, Oostenbrug L, Schreurs WMJ, Sosef MN, Warmerdam FARM]] , Accuracy of Detecting Residual Disease After Cross Neoadjuvant Chemoradiotherapy for Esophageal Cancer (preSANO Trial): Rationale and Protocol. JMIR RES PROTOC 2015;4 (2):e79 [PubMed]
Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, Decaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Moayyedi P, Watson P, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BPL, van der Laan LJW, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J, Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus. GASTROENTEROLOGY 2015;148 (2):367-378 [PubMed]
Varghese S, Newton R, Ross-Innes CS, Lao-Sirieix P, Krishnadath KK, O'Donovan M, Novelli M, Wernisch L, Bergman J, Fitzgerald RC, Analysis of dysplasia in patients with Barrett's esophagus based on expression pattern of 90 genes. GASTROENTEROLOGY 2015;149 (6):1511-1518.e5 [PubMed]
Akiyama J, Alexandre L, Baruah A, Buttar N, Chandra R, Clark AB, Hart AR, Hawk E, Kandioler D, Kappel S, Krishnadath SK, Sharma A, Singh I, Straub D, Triadafilopoulos G, Umar A, Wolf B, Strategy for prevention of cancers of the esophagus. ANN NY ACAD SCI 2014;1325:108-126 [PubMed]
Bansal A, Hong X, Lee IH, Krishnadath KK, Mathur SC, Gunewardena S, Rastogi A, Sharma P, Christenson LK, MicroRNA Expression can be a Promising Strategy for the Detection of Barrett's Esophagus: A Pilot Study. CLIN TRANSL GASTROEN 2014;5:e65 [PubMed]
Davelaar AL. A search for molecular biomarkers in gastro-intestinal cancer. S.l.: s.n.; 2014. 129p. ISBN 9789461825025 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Krishnadath KK, Fockens P; copromotor(s): Parikh KB, Calpe S)
Mari L, Milano F, Parikh K, Straub D, Everts V, Hoeben KK, Fockens P, Buttar NS, Krishnadath KK, A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia. CELL REP 2014;7 (4):1197-1210 [PubMed]
Milano F, Krishnadath KK, Electroporation of dendritic cells with autologous total RNA from tumor material. METHODS MOL BIOL 2014;1139:87-95 [PubMed]
Parikh K, Zhou L, Somasundaram R, Fuhler GM, Deuring JJ, Blokzijl T, Regeling A, Kuipers EJ, Weersma RK, Nuij VJ, Alves M, Vogelaar L, Visser L, de Haar C, Krishnadath KK, van der Woude CJ, Dijkstra G, Faber KN, Peppelenbosch MP, Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease. SCI TRANSL MED 2014;6 (233):233ra53 [PubMed]
Timmer MR, Brankley SM, Gorospe EC, Sun G, Lutzke LS, Iyer PG, Halling KC, Krishnadath KK, Wang KK, Prediction of response to endoscopic therapy of Barrett's dysplasia by using genetic biomarkers. GASTROINTEST ENDOSC 2014;80 (6):984-991 [PubMed]
Gibson MK, Dhaliwal AS, Clemons NJ, Phillips WA, Dvorak K, Tong D, Law S, Pirchi ED, Räsänen J, Krasna MJ, Parikh K, Krishnadath KK, Chen Y, Griffiths L, Colleypriest BJ, Farrant JM, Tosh D, Das KM, Bajpai M, Barrett's esophagus: cancer and molecular biology. ANN NY ACAD SCI 2013;1300 (1):296-314 [PubMed]
Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK, Nano-curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune response. FRONT ONCOL 2013;3:137 [PubMed]
Timmer MR, Beuers U, Fockens P, Ponsioen CY, Rauws EA, Wang KK, Krishnadath KK, Genetic and Epigenetic Abnormalities in Primary Sclerosing Cholangitis-associated Cholangiocarcinoma. INFLAMM BOWEL DIS 2013;19 (8):1789-1797 [PubMed]
Timmer MR, Sun G, Gorospe EC, Leggett CL, Lutzke L, Krishnadath KK, Wang KK, Predictive biomarkers for Barrett's esophagus: so near and yet so far. DIS ESOPHAGUS 2013;26 (6):574-581 [PubMed]
Bennett C, Vakil N, Bergman J, Harrison R, Odze R, Vieth M, Sanders S, Gay L, Pech O, Longcroft-Wheaton G, Romero Y, Inadomi J, Tack J, Corley DA, Manner H, Green S, Al Dulaimi D, Ali H, Allum B, Anderson M, Curtis H, Falk G, Fennerty MB, Fullarton G, Krishnadath K, Meltzer SJ, Armstrong D, Ganz R, Cengia G, Going JJ, Goldblum J, Gordon C, Grabsch H, Haigh C, Hongo M, Johnston D, Forbes-Young R, Kay E, Kaye P, Lerut T, Lovat LB, Lundell L, Mairs P, Shimoda T, Spechler S, Sontag S, Malfertheiner P, Murray I, Nanji M, Poller D, Ragunath K, Regula J, Cestari R, Shepherd N, Singh R, Stein HJ, Talley NJ, Galmiche JP, Tham TCK, Watson P, Yerian L, Rugge M, Rice TW, Hart J, Gittens S, Hewin D, Hochberger J, Kahrilas P, Preston S, Sampliner R, Sharma P, Stuart R, Wang K, Waxman I, Abley C, Loft D, Penman I, Shaheen NJ, Chak A, Davies G, Dunn L, Falck-Ytter Y, Decaestecker J, Bhandari P, Ell C, Griffin SM, Attwood S, Barr H, Allen J, Ferguson MK, Moayyedi P, Jankowski JAZ, Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process. GASTROENTEROLOGY 2012;143 (2):336-346 [PubMed]
Castillo D, Puig S, Iglesias M, Seoane A, de Bolós C, Munitiz V, Parrilla P, Comerma L, Poulsom R, Krishnadath KK, Grande L, Pera M, Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett's Esophagus. J GASTROINTEST SURG 2012;16 (2):227-237 [PubMed]
Su Z, Gay LJ, Strange A, Palles C, Band G, Whiteman DC, Lescai F, Langford C, Nanji M, Edkins S, van der Winkel A, Levine D, Sasieni P, Bellenguez C, Howarth K, Freeman C, Trudgill N, Tucker AT, Pirinen M, Peppelenbosch MP, van der Laan LJW, Kuipers EJ, Drenth JPH, Peters WH, Reynolds JV, Kelleher DP, McManus R, Grabsch H, Prenen H, Bisschops R, Krishnadath K, Siersema PD, van Baal JWPM, Middleton M, Petty R, Gillies R, Burch N, Bhandari P, Paterson S, Edwards C, Penman I, Vaidya K, Ang Y, Murray I, Patel P, Ye W, Mullins P, Wu AH, Bird NC, Dallal H, Shaheen NJ, Murray LJ, Koss K, Bernstein L, Romero Y, Hardie LJ, Zhang R, Winter H, Corley DA, Panter S, Risch HA, Reid BJ, Sargeant I, Gammon MD, Smart H, Dhar A, McMurtry H, Ali H, Liu G, Casson AG, Chow WH, Rutter M, Tawil A, Morris D, Nwokolo C, Isaacs P, Rodgers C, Ragunath K, MacDonald C, Haigh C, Monk D, Davies G, Wajed S, Johnston D, Gibbons M, Cullen S, Church N, Langley R, Griffin M, Alderson D, Deloukas P, Hunt SE, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Anderson M, Brooks C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Markus HS, Mathew CG, Palmer CNA, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood N, Trynka G, Wijmenga C, Cazier JB, Atherfold P, Nicholson AM, Gellatly NL, Glancy D, Cooper SC, Cunningham D, Lind T, Hapeshi J, Ferry D, Rathbone B, Brown J, Love S, Attwood S, Macgregor S, Watson P, Sanders S, Ek W, Harrison RF, Moayyedi P, de Caestecker J, Barr H, Stupka E, Vaughan TL, Peltonen L, Spencer CCA, Tomlinson I, Donnelly P, Jankowski JAZ, Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. NAT GENET 2012;44 (10):1131-+ [PubMed]
Wang KK, Tian JM, Gorospe E, Penfield J, Prasad G, Goddard T, WongKeeSong M, Buttar NS, Lutzke L, Krishnadath S, Medical and endoscopic management of high-grade dysplasia in Barrett's esophagus. DIS ESOPHAGUS 2012;25 (4):349-355 [PubMed]
Dvorak K, Goldman A, Kong J, Lynch JP, Hutchinson L, Houghton JM, Chen H, Chen X, Krishnadath KK, Westra WM, Molecular mechanisms of Barrett's esophagus and adenocarcinoma. ANN NY ACAD SCI 2011;1232 (1):381-391 [PubMed]
Pouw RE, Heldoorn N, Alvarez Herrero L, ten Kate FJW, Visser M , Busch OR, van Berge Henegouwen MI, Krishnadath KK, Weusten BL, Fockens P, Bergman JJ, Do we still need EUS in the workup of patients with early esophageal neoplasia? A retrospective analysis of 131 cases. GASTROINTEST ENDOSC 2011;73 (4):662-668 [PubMed]
Souza RF, Freschi G, Taddei A, Ringressi MN, Bechi P, Castiglione F, Degl'innocenti DR, Triadafilopoulos G, Wang JS, Chang AC, Barr H, Bajpai M, Das KM, Schneider PM, Krishnadath KK, Malhotra U, Lynch JP, Barrett's esophagus: genetic and cell changes. ANN NY ACAD SCI 2011;1232 (1):18-35 [PubMed]
Stingl C, van Vilsteren FGI, Guzel C, ten Kate FJW, Visser M , Krishnadath KK, Bergman JJ, Luider TM, Reproducibility of Protein Identification of Selected Cell Types in Barrett's Esophagus Analyzed by Combining Laser-Capture Microdissection and Mass Spectrometry. J PROTEOME RES 2011;10 (1):288-298 [PubMed]
Curvers WL. Endoscopic surveillance and advanced imaging techniques in Barrett's esophagus. s.l.: s.n.; 2010. 271p. ISBN 9789090255545 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fockens P, ten Kate FJW; copromotor(s): Bergman JJGHM, Krishnadath KK)
Curvers WL, ten Kate FJ, Krishnadath KK, Visser M , Elzer B, Baak LC, Bohmer C, Mallant-Hent RC, van Oijen A, Naber AH, Scholten P, Busch OR, Blaauwgeers HGT, Meijer GA, Bergman JJGHM, Low-Grade Dysplasia in Barrett's Esophagus: Overdiagnosed and Underestimated. AM J GASTROENTEROL 2010;105 (7):1523-1530 [PubMed]
Hulshof MCCM, van Haaren PMA, Zum Vörde Sive Vörding PJ, Krishnadath S, Marsman WA, van Berge Henegouwen MI, Geijsen ED, Crezee J, Radiotherapy combined with hyperthermia for primary malignant melanomas of the esophagus. DIS ESOPHAGUS 2010;23 (8):E42-E47 [PubMed]
Milano F, Guarriera M, Rygiel AM, Krishnadath KK, Trastuzumab Mediated T-Cell Response against HER-2/Neu Overexpressing Esophageal Adenocarcinoma Depends on Intact Antigen Processing Machinery. PLOS ONE 2010;5 (8):e12424 [PubMed]
Pacha AF, Krishnadath KK, A reappraisal of brush cytology for screening of Barrett's esophagus. ENDOSCOPY 2010;42 (10):865-866 [PubMed]
Rygiel AM, Milano F, ten Kate FJ, Bergman JJGHM, Krishnadath KK, Low Level of Her-2 Locus Amplification by Fluorescent In Situ Hybridization Does Not Correlate with Her-2 Protein Overexpression by Immunohistochemistry in Barrett's Esophagus. J ONCOL 2010;2010:382582 [PubMed]
Taniguchi K, Krishnadath KK, Qian C, Burgart LJ, Thibodeau SN, Kanematsu T, Liu W, AXIN2 Mutations in Sporadic Ampullary Carcinoma Correlate with Young Age Onset and Aggressive Phenotype. J SURG RES 2010;158 (2):192
Pouw RE, Gondrie JJ, Rygiel AM, Sondermeijer CM, ten Kate FJ, Odze RD, Vieth M, Krishnadath KK, Bergman JJ, Properties of the Neosquamous Epithelium After Radiofrequency Ablation of Barrett's Esophagus Containing Neoplasia. AM J GASTROENTEROL 2009;104 (6):1366-1373 [PubMed]
Weinert BT, Krishnadath KK, Milano F, Pedersen AW, Claesson MH, Zocca MB, Real-time PCR analysis of genes encoding tumor antigens in esophageal tumors and a cancer vaccine. CANCER IMMUN 2009;9:9 [PubMed]
Bozikas A, Marsman WA, Rosmolen WD, van Baal JWPM, Kulik W, ten Kate FJW, Krishnadath KK, Bergman JJGHM, The effect of oral administration of ursodeoxycholic acid and high-dose proton pump inhibitors on the histology of Barrett's esophagus. DIS ESOPHAGUS 2008;21 (4):346-354 [PubMed]
Curvers WL, Peters FP, Elzer B, Schaap AJCM, Baak LC, van Oijen A, Mallant-Hent RM, ten Kate F, Krishnadath KK, Bergman JJGHM, Quality of Barrett's surveillance in The Netherlands: a standardized review of endoscopy and pathology reports. EUR J GASTROEN HEPAT 2008;20 (7):601-607 [PubMed]
Gondrie JJ, Pouw RE, Sondermeijer CMT, Peters FP, Curvers WL, Rosmolen WD, Krishnadath KK, ten Kate F, Fockens P, Bergman JJ, Stepwise circumferential and focal ablation of Barrett's esophagus with high-grade dysplasia: results of the first prospective series of 11 patients. ENDOSCOPY 2008;40 (5):359-369 [PubMed]
Milano F, Jorritsma T, Rygiel AM, Bergman JJ, Sondermeijer C, ten Brinke A, van Ham SM, Krishnadath KK, Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment. SCAND J IMMUNOL 2008;68 (6):616-623 [PubMed]
Milano F, Krishnadath KK, Novel therapeutic strategies for treating esophageal adenocarcinoma: the potential of dendritic cell immunotherapy and combinatorial regimens. HUM IMMUNOL 2008;69 (10):614-624 [PubMed]
Peters FP, Brakenhoff KPM, Curvers WL, Rosmolen WD, Fockens P, ten Kate FJW, Krishnadath KK, Bergman JJGHM, Histologic evaluation of resection specimens obtained at 293 endoscopic resections in Barrett's esophagus. GASTROINTEST ENDOSC 2008;67 (4):604-609 [PubMed]
Peters FP, Curvers WL, Rosmolen WD, de Vries CE, ten Kate FJW, Krishnadath KK, Fockens P, Bergman JJGHM, Surveillance history of endoscopically treated patients with early Barrett's neoplasia: nonadherence to the Seattle biopsy protocol leads to sampling error. DIS ESOPHAGUS 2008;21 (6):475-479 [PubMed]
Pouw RE, Gondrie JJ, Sondermeijer CM, ten Kate FJ, van Gulik TM, Krishnadath KK, Fockens P, Weusten BL, Bergman JJ, Eradication of Barrett esophagus with early neoplasia by radiofrequency ablation, with or without endoscopic resection. J GASTROINTEST SURG 2008;12 (10):1627-36; discussion 1636-7 [PubMed]
Prasad GA, Wang KK, Halling KC, Buttar NS, Wongkeesong LM, Zinsmeister AR, Brankley SM, Fritcher EGB, Westra WM, Krishnadath KK, Lutzke LS, Borkenhagen LS, Utility of biomarkers in prediction of response to ablative therapy in Barrett's esophagus. GASTROENTEROLOGY 2008;135 (2):370-379 [PubMed]
Rygiel AM. Genetic markers in malignant progression of Barrett's esophagus. s.l.: s.n.; 2008. 147p. ISBN 9789064641800 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Peppelenbosch MP, Fockens P; copromotor(s): Krishnadath KK, Bergman JJGHM)
Rygiel AM, Milano F, ten Kate FJ, de Groot JG, Peppelenbosch MP, Bergman JJGHM, Krishnadath KK, Assessment of chromosomal gains as compared to DNA content changes is more useful to detect dysplasia in Barrett's esophagus brush cytology specimens. GENE CHROMOSOME CANC 2008;47 (5):396-404 [PubMed]
Rygiel AM, Milano F, ten Kate FJ, Schaap A, Wang KK, Peppelenbosch MP, Bergman JJGHM, Krishnadath KK, Gains and amplifications of c-myc, EGFR, and 20.q13 loci in the no dysplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus. CANCER EPIDEM BIOMAR 2008;17 (6):1380-1385 [PubMed]
van Baal JWPM, Bozikas A, Pronk R, ten Kate FJW, Milano F, Rygiel AM, Rosmolen WD, Peppelenbosch MP, Bergman JJGHM, Krishnadath KK, Cytokeratin and CDX-2 expression in Barrett's esophagus. SCAND J GASTROENTERO 2008;43 (2):132-140 [PubMed]
van Baal JWPM, Krishnadath KK, High throughput techniques for characterizing the expression profile of Barrett's esophagus. DIS ESOPHAGUS 2008;21 (7):634-640 [PubMed]
van Baal JWPM, Milana F, Rygiel AM, Sondermeijer CMT, Spek CA, Bergman JJGHM, Peppelenbosch MP, Krishnadath KK, A comparative analysis by SAGE of gene expression profiles of esophageal adenocarcinoma and esophageal squamous cell carcinoma. CELL ONCOL 2008;30 (1):63-75 [PubMed]
van Baal JWPM, Rygiel AM, Milano F, Anderson M, Bergman JJGHM, Spek CA, Wang KK, Peppelenbosch MP, Krishnadath KK, Gene expression profile comparison of Barrett's esophagus epithelial cell cultures and biopsies. DIS ESOPHAGUS 2008;21 (7):628-633 [PubMed]
Krishnadath KK, Novel findings in the pathogenesis of esophageal columnar metaplasia or Barrett's esophagus. CURR OPIN GASTROEN 2007;23 (4):440-445 [PubMed]
Milano F. Developing novel stategies for treating eosophageal cancer: dendritic cells immunotherapy, T cell responses and an exploration of the tumor microenvironment. s.l.: s.n.; 2007. 159p. ISBN 9789064641596 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Peppelenbosch MP, Boeckxstaens GEE; copromotor(s): Krishnadath KK)
Milano F, Rygiel AM, Buttar N, Bergman JJGHM, Sondermeijer C, van Baal JWPM, ten Brinke A, Kapsenberg M, van Ham SM, Peppelenbosch MP, Krishnadath KK, An ex vivo readout for evaluation of dendritic cell-induced autologous cytotoxic T lymphocyte responses against esophageal cancer. CANCER IMMUNOL IMMUN 2007;56 (12):1967-1977 [PubMed]
Milano F, van Baal JWPM, Buttar NS, Rygiel AM, de Kort F, DeMars CJ, Rosmolen WD, Bergman JJGHM, van Marle J, Wang KK, Peppelenbosch MP, Krishnadath KK, Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. GASTROENTEROLOGY 2007;132 (7):2412-2421 [PubMed]
Milano F, van Baal JWPM, Rygiel AM, Bergman JJGHM, van Deventer SJH, Kapsenberg ML, Peppelenbosch MP, Krishnadath KK, An improved protocol for generation of immuno-potent dendritic cells through direct electroporation of CD14+monocytes. J IMMUNOL METHODS 2007;321 (1-2):94-106 [PubMed]
Moons LMG, Kuipers EJ, Rygiel AM, Groothuismink AZM, Geldof H, Bode WA, Krishnadath KK, Bergman JJGHM, van Vliet AHM, Siersema PD, Kusters JG, COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma. AM J GASTROENTEROL 2007;102 (11):2373-2379 [PubMed]
Peters FP. Endoscopic treatment of early Barrett's neoplasia. s.l.: s.n.; 2007. 218p. ISBN 9789090215389 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Fockens P, ten Kate FJW; copromotor(s): Bergman JJGHM, Krishnadath KK)
Peters FP, Brakenhoff KPM, Curvers WL, Rosmolen WD, ten Kate FJW, Krishnadath KK, Fockens P, Bergman JJGHM, Endoscopic cap resection for treatment of early Barrett's neoplasia is safe: a prospective analysis of acute and early complications in 216 procedures. DIS ESOPHAGUS 2007;20 (6):510-515 [PubMed]
Peters FP, Krishnadath KK, Rygiel AM, Curvers WL, Rosmolen WD, Stepwise radical endoscopic resection of the complete Barrett's esophagus with early neoplasia successfully eradicates pre-existing genetic abnormalities. AM J GASTROENTEROL 2007;102 (9):1853-1861 [PubMed]
Peters FR, Kara MA, Curvers WL, Rosmolen WD, Fockens P, Krishnadath KK, ten Kate FJW, Bergman JJGHM, Multiband mucosectomy for endoscopic resection of Barrett's esophagus: feasibility study with matched historical controls. EUR J GASTROEN HEPAT 2007;19 (4):311-315 [PubMed]
Prasad GA, Wang KK, Buttar NS, Wongkeesong LM, Krishnadath KK, Nichols FC III, Lutzke LS, Borkenhagen LS, Long-term survival following endoscopic and surgical treatment of high-grade dysplasia in Barrett's esophagus. GASTROENTEROLOGY 2007;132 (4):1226-1233 [PubMed]
Rygiel AM, van Baal JWPM, Milano F, Wang KK, ten Kate FJ, Fockens P, Rosmolen WD, Bergman JJGHM, Peppelenbosch MP, Krishnadath KK, Efficient automated assessment of genetic abnormalities detected by fluorescence in situ hybridization on brush cytology in a Barrett esophagus surveillance population. CANCER-AM CANCER SOC 2007;109 (10):1980-1988 [PubMed]
Peters FP, Kara MA, Rosmolen WD, ten Kate FJW, Krishnadath KK, van Lanschot JJB, Fockens P, Bergman JJGHM, Stepwise radical endoscopic resection is effective for complete removal of Barrett's esophagus with early neoplasia: a prospective study. AM J GASTROENTEROL 2006;101 (7):1449-1457 [PubMed]
van Baal JWPM. Molecular mechanisms in the development of Barrett's esophagus. S.l.: s.n.; 2006. 176p. ISBN 9789064640469 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Peppelenbosch MP; copromotor(s): Krishnadath KK)
van Baal JWPM, Diks SH, Wanders RJA, Rygiel AM, Milano F, Joore J, Bergman JJGHM, Peppelenbosch MP, Krishnadath KK, Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia. CANCER RES 2006;66 (24):11605-11612 [PubMed]
Kara MA, Peters FP, Rosmolen WD, Krishnadath KK, ten Kate FJ, Fockens P, Bergman JJGH, High-resolution endoscopy plus chromoendoscopy or narrow-band imaging in Barrett's esophagus: a prospective randomized crossover study. ENDOSCOPY 2005;37 (10):929-936 [PubMed]
Peters F, Kara M, Rosmolen W, Aalders M, ten Kate F, Krishnadath K, van Lanschot J, Fockens P, Bergman J, Poor results of 5-aminolevulinic acid-photodynamic therapy for residual high-grade dysplasia and early cancer in barrett esophagus after endoscopic resection. ENDOSCOPY 2005;37 (5):418-424 [PubMed]
Peters FP, Kara MA, Rosmolen WD, Aalders MCG, ten Kate FJW, Bultje BC, Krishnadath KK, Fockens P, van Lanschot JJB, van Deventer SJH, Bergman JJGHM, Endoscopic treatment of high-grade dysplasia and early stage cancer in Barrett's esophagus. GASTROINTEST ENDOSC 2005;61 (4):506-514 [PubMed]
van Baal JWPM, Milano F, Rygiel AM, Bergman JJGHM, Rosmolen WD, van Deventer SJH, Wang KK, Peppelenbosch MP, Krishnadath KK, A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia. GASTROENTEROLOGY 2005;129 (4):1274-1281 [PubMed]
Verhaar A, Krishnadath KK, Peppelenbosch MP, Using microgravity for defining novel anti-atherosclerotic therapy. CURR GENOMICS 2005;6 (6):487-490
Bergman JJ, Marsman WA, Krishnadath KK, Fockens P, van Lanschot JJ, Tytgat GN, Barrett-slokdarm: endoscopische behandeling van hooggradige dysplasie en vroegcarcinomen. NED TIJDSCHR GENEESKD 2003;147 (46):2275-2281 [PubMed]
Marsman WA, Krishnadath KK, Fockens P, Tytgat GN, Bergman JJ, Barrett-slokdarm: nieuwe ontwikkelingen in endoscopische surveillance. NED TIJDSCHR GENEESKD 2003;147 (46):2268-2274 [PubMed]
Buttar NS, Wang KK, Anderson MA, Dierkhising RA, Pacifico RJ, Krishnadath KK, Lutzke LS, The effect of selective cyclooxygenase-2 inhibition in Barrett's esophagus epithelium: an in vitro study. JNCI-J NATL CANCER I 2002;94 (6):422-429 [PubMed]
Buttar NS, Wang KK, Leontovich O, Westcott JY, Pacifico RJ, Anderson MA, Krishnadath KK, Lutzke LS, Burgart LJ, Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. GASTROENTEROLOGY 2002;122 (4):1101-1112 [PubMed]
Buttar NS, Wang KK, Lutzke LS, Krishnadath KK, Anderson MA, Combined endoscopic mucosal resection and photodynamic therapy for esophageal neoplasia within Barrett's esophagus. GASTROINTEST ENDOSC 2001;54 (6):682-688 [PubMed]
Buttar NS, Wang KK, Sebo TJ, Riehle DM, Krishnadath KK, Lutzke LS, Anderson MA, Petterson TM, Burgart LJ, Extent of high-grade dysplasia in Barrett's esophagus correlates with risk of adenocarcinoma. GASTROENTEROLOGY 2001;120 (7):1630-1639 [PubMed]
Krishnadath KK, Reid BJ, Wang KK, Biomarkers in Barrett esophagus. MAYO CLIN PROC 2001;76 (4):438-446 [PubMed]
Krishnadath KK, Wang KK, Taniguchi K, Sebo TJ, Buttar NS, Anderson MA, Lutzke LS, Liu W, Persistent genetic abnormalities in Barrett's esophagus after photodynamic therapy. GASTROENTEROLOGY 2000;119 (3):624-630 [PubMed]
Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI, Thibodeau SN, Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. NAT GENET 2000;26 (2):146-147 [PubMed]
Liu WG, Dong XY, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian CP, Christensen E, Schmidt SJ, Roche PC, Smith DI, Thibodeau SN, Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling (vol 26, pg 146, 2000). NAT GENET 2000;26 (4):501
Krishnadath KK, Tilanus HW, van Blankenstein M, Hop WC, Kremers ED, Dinjens WN, Bosman FT, Reduced expression of the cadherin-catenin complex in oesophageal adenocarcinoma correlates with poor prognosis. J PATHOL 1997;182 (3):331-338 [PubMed]
Rosso SM, van Dekken H, Krishnadath KK, Alers JC, Kros JM, Detection of chromosomal changes by interphase cytogenetics in biopsies of recurrent astrocytomas and oligodendrogliomas. J NEUROPATH EXP NEUR 1997;56 (10):1125-1131 [PubMed]
Kros JM, Hop WC, Godschalk JJ, Krishnadath KK, Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas. CANCER-AM CANCER SOC 1996;78 (5):1107-1113 [PubMed]
Alers JC, Krijtenburg PJ, Vissers KJ, Krishnadath SK, Bosman FT, van Dekken H, Interphase in situ hybridization to disaggregated and intact tissue specimens of prostatic adenocarcinomas. HISTOCHEM CELL BIOL 1995;104 (6):479-486 [PubMed]
Krishnadath KK, Tilanus HW, van Blankenstein M, Bosman FT, Mulder AH, Accumulation of p53 protein in normal, dysplastic, and neoplastic Barrett's oesophagus. J PATHOL 1995;175 (2):175-180 [PubMed]
Krishnadath KK, Tilanus HW, van Blankenstein M, Hop WC, Teijgeman R, Mulder AH, Bosman FT, van Dekken H, Accumulation of genetic abnormalities during neoplastic progression in Barrett's esophagus. CANCER RES 1995;55 (9):1971-1976 [PubMed]
Krishnadath KK, van Blankenstein M, Tilanus HW, Prognostic value of p53 in Barrett's oesophagus. EUR J GASTROEN HEPAT 1995;7 (1):81-84 [PubMed]
Bot FJ, Godschalk JC, Krishnadath KK, van der Kwast TH, Bosman FT, Prognostic factors in renal-cell carcinoma: immunohistochemical detection of p53 protein versus clinico-pathological parameters. INT J CANCER 1994;57 (5):634-637 [PubMed]
Krishnadath KK, Tilanus HW, Alers JC, Mulder AH, van Dekken H, Detection of genetic changes in Barrett's adenocarcinoma and Barrett's esophagus by DNA in situ hybridization and immunohistochemistry. CYTOMETRY 1994;15 (2):176-184 [PubMed]
Kros JM, Godschalk JJ, Krishnadath KK, van Eden CG, Expression of p53 in oligodendrogliomas. J PATHOL 1993;171 (4):285-290 [PubMed]
Key publications

Milano F, van Baal JWPM, Buttar NS, Rygiel AM, de Kort F, DeMars CJ, Rosmolen WD, Bergman JJGHM, van Marle J, Wang KK, Peppelenbosch MP, Krishnadath KK, Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. GASTROENTEROLOGY 2007;132 (7):2412-2421 [PubMed]
van Baal JWPM, Milano F, Rygiel AM, Bergman JJGHM, Rosmolen WD, van Deventer SJH, Wang KK, Peppelenbosch MP, Krishnadath KK, A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia. GASTROENTEROLOGY 2005;129 (4):1274-1281 [PubMed]
Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI, Thibodeau SN, Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. NAT GENET 2000;26 (2):146-147 [PubMed]
Martinez P, Timmer MR, Lau CT, Calpe S, Sancho-Serra MDC, Straub D, Baker AM, Meijer SL, ten Kate FJW, Mallant-Hent RC, Naber AHJ, van Oijen AHAM, Baak LC, Scholten P, Böhmer CJM, Fockens P, Bergman JJGHM, Maley CC, Graham TA, Krishnadath KK, Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus. NAT COMMUN 2016;7:12158 [PubMed]
Timmer MR, Martinez P, Lau CT, Westra WM, Calpe S, Rygiel AM, Rosmolen WD, Meijer SL, ten Kate FJW, Dijkgraaf MGW, Mallant-Hent RC, Naber AHJ, van Oijen AHAM, Baak LC, Scholten P, Böhmer CJM, Fockens P, Maley CC, Graham TA, Bergman JJGHM, Krishnadath KK, Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study. GUT 2016;65 (10):1602-1610 [PubMed]


All Publications

Research programmes

Understanding of the inflammation-dysplasia-carcinoma sequence within the gastrointestinal tract

1. Fundamental cell biological studies for understanding the biology of Barrett’s esophagus
These fundamental studies aim at understanding signalling pathways and other biological mechanisms that lead to transdifferentiation of esophageal epithelium into intestinal type of metaplasia (IM) or Barrett’s esophagus (BE) on stem cell level (Collaboration with J.P. Medema). Recently, the key mechanisms leading to IM have been identified. Currently, diverse transgenic and physiological novel mouse models for Barrett’s esophagus are being developed and lineage tracing studies are performed (Collaboration with prof. H. Clevers Hubrecht Institute Utrecht; prof. Dr. K. Wang and N. Buttar, Mayo Clinic, Rochester, USA). In addition, molecular targets for imaging and treatment of benign and malignant Barrett’s esophagus are being developed and the initial in vitro testing is being performed (collaboration with).

2. Biological marker studies for improving surveillance of Barrett’ esophagus patients
Brush cytology specimens of BE cohorts are being screened for molecular abnormalities by using Fluorescent In Situ Hybridization (FISH). These studies have been recently awarded by two grants (KWF 2008 and NWO, preventie 2008). A panel of prognostic and diagnostic DNA FISH markers have been identified in the AMC cohort. At the end of 2010 the AMC cohort of over 160 BE patients has reached an average 5-year prospective follow up. Based on this data a patent is filed on a novel FISH biomarker assay which has a high long term prognostic power (OR >5) to stratify Barrett patients in low and high risk groups (disclosure will be on the 6th of Oct on the NVGE, Nederlandse Vereniging voor Gastroenterologie). Currently, this prognostic marker set is being validated in a cohort of >300 unselected BE from six community hospitals, which will reach 5 year FU at the end of 2012. An interim analysis is highly promising. In addition the marker set will be validated in a UK population of 500 Barrett patients, collaboration with. Dr. R. Fitzgerald, Cambridge, UK. Also NIH funding is applied for to test the marker set in a US population, collaboration with K.K. Wang Mayo Clinic, Rochester USA.

3. Identifying genetic susceptibility genes for Barrett’s esophagus
The population at highest risk for developing BE are middle-aged Caucasian men. Certain Y-chromosome haplotypes were found as protective factors for developing BE in Dutch cohorts. These results are currently being validated in a cohort of BE patients (n=700) of the Mayo Clinic, Rochester, USA, collaboration with Dr. K. Wang.

4. Research collaborator on clinical studies of Barrett’s esophagus patients
In collaboration with the group of Dr. J. Bergman, there is involvement in several ongoing clinical studies on BE.
Theme:  Gastro-intestinal diseases and oncology

Manuscripts recently accpeted for publication:

"A novel pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia."Luigi Mari, Francesca Milano, Kaushal Parikh, Danielle Straub, Vincent Everts, Kees K. Hoeben, Paul Fockens, Navtej S. Buttar, Kausilia K. Krishnadath. Cell Reports Manuscript accepted 2014

"Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn’s disease.K. Parikh'; R. Somasundaram; G. zhoulu; G.M. Fuhler; J.J. Deuring; Blokzijl, T; Regeling, E.J. Kuipers; Weersma, RK; V.J.A.A. Nuij; M.M. R.B. Parikh - Alves; L. Vogelaar; Visser, L; C.G. de Haar; K.K. Krishnadath; C.J. van der Woude; Dijkstra, G, M.P. Peppelenbosch, Science Translational Medicine Manuscript accepted 2014

Faculty
Prof. dr. K.K. Krishnadath

Postdocs
S. Calpe PhD

PhD Students
S.J.M. Hoefnagel
A.C. Pacheco Correia MSc
D. Straub MSc
Drs. W.M. Westra

Other research related activities
  • Membership of medical or scientific committee, University of Amsterdam, Memeber of the animal ethical committee
  • Membership of advisory board / Consultant, Mayo Foundation Rochester USA
Current research funding
  • Europese Unie
  • Technologiestichting STW
  • UCSF Controller’s Office