• Principal Investigator
  • Male

Prof. dr. A.G.J.M. van Leeuwen MSc PhD

Position: Professor
Main activities: Research, Teaching
Specialisation: Biomedical Physics and Biomedical Photonics
foto A.G.J.M. van Leeuwen is one of the AMC Principal Investigators
Focus of research:

The research of the Biomedical Photonics group of the Biomedical Engineering and Physics department of the AMC (headed by Ton van Leeuwen) focuses on the physics of the interaction of light with tissue, and to use that knowledge for the development, introduction and clinical evaluation of (newly developed) optical imaging and analysis techniques for gathering quantitative functional and molecular information of tissue or tissue sample ("optical biopsy"). The research bridges the gap between lab and clinic (“bench to bedside”).

 

The research is structured along the following research lines:

 

  1. Hyper-spectral monitoring and imaging: based on the research of Maurice Aalders, the assessment of the concentration of blood and blood derivatives as bilirubin in the skin of neonates (in cooperation with neonatology), met-, deoxy- and oxyhemoglobin in the skin (for age determination of bruises to improve child abuse detection) and hemichrome (for ex-vivo blood-stain analysis, with the Netherlands Forensic Institute) is pursued.
  2. Functional imaging: based on the fundamental research of Dirk Faber, the use of the intrinsic contrast of OCT is explored with Martijn de Bruin for the in vivo staging and grading of tumors, together with clinical departments (e.g. Urology, Pulmonology, MDL) and the NKI. Novel OCT signal analysis is explored to determine blood velocity profiles, perfusion and diffusion and relate this information to pathology, together with clinical departments as Ophthalmology. The integration and combination of different imaging technologies (e.g. OCT and CT, (Raman) spectroscopy and OCT) is explored and clinically evaluated with e.g. departments of Radiation Therapy, Cardiology and Plastic and Reconstructive Surgery
  3. Microvesicles detection: in cooperation with experimental clinical chemistry, new optical techniques for the detection of microvesicles in blood plasm are developed. In this novel research line, we aim to quantify the size distribution, the concentration (via sophisticated microscopic detection techniques) and cellular origin (via spectroscopic techniques) of these small (30-1000 nm) particles in order to design "liquid biopsytools. We intiated the STW perspectief program CANCER-ID.
  4. Photonic device development: We develop novel photonic devices, based on minimally invasive designs and integrated optics, which are suitable for small and dedicated monitoring and imaging devices in the clinic ("cleanroom to clinic"). 

Our research is embedded in the Center of Research Excellence on Innovative Medical DevicesInstitute Quantivision”, a collaboration between UvA-FNWI, AMC, NKI, VUmc and VU, in which Ton van Leeuwen is the technical scientific leader. Our group is also part of the “LaserLaB” of the VU and the Co van Ledden Hulsebosch Center for Forensic Sciences of the UvA-FNWI, NFI and AMC.

 

AMC themes: Cardiovascular Diseases, Oncology
Departments: Biomedical Engineering and Physics
Almasian M , van Leeuwen TG, Faber DJ, OCT Amplitude and Speckle Statistics of Discrete Random Media. SCI REP-UK 2017;7 (1):14873 [PubMed]
Buijs M, van Lienden KP, Wagstaff PGK, Scheltema MJV, de Bruin DM, Zondervan PJ, van Delden OM, van Leeuwen TG, de La Rosette JJMCH, Laguna MP, Irreversible Electroporation for the Ablation of Renal Cell Carcinoma: A Prospective, Human, In Vivo Study Protocol (IDEAL Phase 2b). JMIR RES PROTOC 2017;6 (2):e21 [PubMed]
Buijs M, Wagstaff PGK, de Bruin DM, Zondervan PJ, Savci-Heijink CD, van Delden OM, van Leeuwen TG, van Moorselaar RJA, de La Rosette JJMCH, Laguna Pes MP, An In-vivo Prospective Study of the Diagnostic Yield and Accuracy of Optical Biopsy Compared with Conventional Renal Mass Biopsy for the Diagnosis of Renal Cell Carcinoma: The Interim Analysis. EUR UROL FOCUS 2017;ahead of print [PubMed]
Bus MT, de Bruin DM, Kamphuis GM, Zondervan PJ, Laguna Pes MP, de Reijke TM, van Leeuwen TG, de la Rosette JJ, Current position of diagnostics and surgical treatment for upper tract urothelial carcinoma. MINERVA UROL NEFROL 2017;69 (2):159-165 [PubMed]
Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S, Emanueli C, Gasecka A, Hendrix A, Hill AF, Lacroix R, Lee Y, van Leeuwen TG, Mackman N, Mäger I, Nolan JP, van der Pol E, Pegtel DM, Sahoo S, Siljander PRM, Sturk G, de Wever O, Nieuwland R, Methodological Guidelines to Study Extracellular Vesicles. CIRC RES 2017;120 (10):1632-1648 [PubMed]
Gool EL, Stojanovic I, Schasfoort RBM, Sturk A, van Leeuwen TG, Nieuwland R, Terstappen LWMM, Coumans FAW, Surface Plasmon Resonance is an Analytically Sensitive Method for Antigen Profiling of Extracellular Vesicles. CLIN CHEM 2017;63 (10):1633-1641 [PubMed]
Jansen SM, de Bruin DM, Faber DJ, Dobbe IJGG, Heeg E, Milstein DMJ, Strackee SD, van Leeuwen TG, Applicability of quantitative optical imaging techniques for intraoperative perfusion diagnostics: a comparison of laser speckle contrast imaging, sidestream dark-field microscopy, and optical coherence tomography. J BIOMED OPT 2017;22 (8):086004-9 [PubMed]
Jelvehgaran P, Alderliesten T, Weda JJA, de Bruin M, Faber DJ, Hulshof MCCM, van Leeuwen TG, van Herk M, de Boer JF, Visibility of Fiducial Markers used for Image-Guided Radiation Therapy on Optical Coherence Tomography for Registration with CT: an Esophageal Phantom Study. MED PHYS 2017;ahead of print [PubMed]
Muller BG, Swaan A, de Bruin DM, van den Bos W, Schreurs AW, Faber DJ, Zwartkruis ECH, Rozendaal L, Vis AN, Nieuwenhuijzen JA, van Moorselaar RJA, van Leeuwen TG, de la Rosette JJMCH, Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer. TECHNOL CANCER RES T 2017;16 (1):57-65 [PubMed]
Post AL , Jacques SL, Sterenborg HJCM, Faber DJ, van Leeuwen TG, Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture. J BIOMED OPT 2017;22 (5):050501 [PubMed]
Schreurs TJL, van Gorkum R, Zhang XU, Faber DJ, van Leeuwen TG, Nicolay K, Strijkers GJ, Noninvasive fluence rate mapping in living tissues using magnetic resonance thermometry. J BIOMED OPT 2017;22 (3):036001 [PubMed]
Swager AF, Faber DJ, de Bruin DM, Weusten BL, Meijer SL, Bergman JJ, Curvers WL, van Leeuwen TG, Quantitative attenuation analysis for identification of early Barrett's neoplasia in volumetric laser endomicroscopy. J BIOMED OPT 2017;22 (8):086001 [PubMed]
Zhang XU, Post AL , Faber DJ, van Leeuwen TG, Sterenborg HJCM, Single fiber reflectance spectroscopy calibration. J BIOMED OPT 2017;22 (10):100502-4 [PubMed]
Bongers C, Riordan AJ, Hopman M, Eijsvogels T, van Leeuwen TG, Nieuw licht op de vochtbalans tijdens inspanning. SPORTGERICHT 2016;70 (3):56-60
Bus MTJ, de Bruin DM, Faber DJ, Kamphuis GM, Zondervan PJ, Laguna-Pes MP, van Leeuwen TG, de Reijke TM, de la Rosette JJMCH, Optical Coherence Tomography as a Tool for In Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study of Diagnostic Accuracy. J UROLOGY 2016;196 (6):1749-1755 [PubMed]
Cernohorsky P, Jansen SM, de Bruin DM, van der Pol E, Savci-Heijink CD, Strackee SD, Faber DJ, van Leeuwen TG, Quantitative assessment of optical properties in healthy cartilage and repair tissue by optical coherence tomography and histology.. IEEE J SEL TOP QUANT 2016;22 (3):6801407
Chang L, Weiss N, van Leeuwen TG, Pollnau M, de Ridder RM, Wörhoff K, Subramaniam V, Kanger JS, Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm. OPT EXPRESS 2016;24 (12):12635-12650 [PubMed]
de Bruin DM, Broekgaarden M, van Gemert MJC, Heger M, de la Rosette JJ, van Leeuwen TG, Faber DJ, Assesment of apoptosis induced changes in scattering using optical coherence tomography. J BIOPHOTONICS 2016;9 (9):913-923 [PubMed]
Holz JA. Luminescence imaging and spectroscopy for the detection of early neoplasia in Barrett’s esophagus. S.l.: s.n.; 2016. 151p. ISBN 978-90-9029523-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM, Bergman JJGHM; copromotor(s): Aalders MCG)
Holz JA, Boerwinkel DF, Meijer SL, Visser M , van Leeuwen TG, Bergman JJGHM, Aalders MCG, Fluorescence characteristics of human Barrett tissue specimens grafted on chick chorioallantoic membrane. LASER MED SCI 2016;31 (1):137-144 [PubMed]
Muller BG, de Bruin DM, Brandt MJ, van den Bos W, van Huystee S, Faber DJ, Savci D, Zondervan PJ, de Reijke TM, Laguna-Pes MP, van Leeuwen TG, de La Rosette JJMCH, Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling. J BIOPHOTONICS 2016;9 (5):490-498 [PubMed]
Nadort A, Kalkman K, van Leeuwen TG, Faber DJ, Quantitative blood flow velocity imaging using laser speckle flowmetry. SCI REP-UK 2016;6:25258 [PubMed]
Stehouwer M, Verbraak FD, Schlingemann RO, van Leeuwen TG, Detecting signs of retinal leakage in exudative AMD using Cirrus OCT versus SL SCAN-1, a novel integrated FD-OCT into a common slit lamp. GRAEF ARCH CLIN EXP 2016;254 (1):37-41 [PubMed]
Swager A, Boerwinkel DF, de Bruin DM, Weusten BL, Faber DJ, Meijer SL, van Leeuwen TG, Curvers WL, Bergman JJ, Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation. DIS ESOPHAGUS 2016;29 (6):505-512 [PubMed]
Swager AF, Boerwinkel DF, de Bruin DM, Faber DJ, van Leeuwen TG, Weusten BL, Meijer SL, Bergman JJ, Curvers WL, Detection of buried Barrett's glands after radiofrequency ablation with volumetric laser endomicroscopy. GASTROINTEST ENDOSC 2016;83 (1):80-88 [PubMed]
van Dam A, Aalders MCG, Todorovski T, van Leeuwen TG, Lambrechts SAG, On the autofluorescence of aged fingermarks. FORENSIC SCI INT 2016;258:19-25 [PubMed]
van Dam A, van Beek FT, Aalders MCG, van Leeuwen TG, Lambrechts SAG, Techniques that acquire donor profiling information from fingermarks - A review. SCI JUSTICE 2016;56 (2):143-154 [PubMed]
van den Bos W. Focal therapy in prostate cancer. S.l.: s.n.; 2016. 221p. ISBN 978-94-6233-290-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de la Rosette JJCMH, van Leeuwen AGJM; copromotor(s): Laguna Pes MP, Reijke TM, de Bruin DM)
van der Pol E, Mudde YD, Coumans FAW, van Leeuwen TG, Sturk A, Nieuwland R, Wound scabs protect regenerating tissue against harmful ultraviolet radiation. MED HYPOTHESES 2016;96:39-41 [PubMed]
Wagstaff PGK. New techniques in the diagnosis and treatment of renal masses. S.l.: s.n.; 2016. 140p. ISBN 978-94-6233-287-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Laguna Pes MP, van Leeuwen AGJM; copromotor(s): de la Rosette JJMCH, van Delden OM, de Bruin DM)
Wagstaff PGK, Ingels A, de Bruin DM, Buijs M, Zondervan PJ, Savci Heijink CD, van Delden OM, Faber DJ, van Leeuwen TG, van Moorselaar RJA, de La Rosette JJMCH, Laguna Pes MP, Percutaneous Needle Based Optical Coherence Tomography for the Differentiation of Renal Masses: a Pilot Cohort. J UROLOGY 2016;195 (5):1578-1585 [PubMed]
Weiss N. The amplitude and the phase or: Measuring directional and random motion with optical coherence tomography. S.l.: s.n.; 2016. 123p. ISBN 978-94-6182-737-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM; copromotor(s): Kalkman J)
Weiss N, El Tayeb El Obied K, Kalkman J, Lammertink RGH, van Leeuwen TG, Measurement of biofilm growth and local hydrodynamics using optical coherence tomography. BIOMED OPT EXPRESS 2016;7 (9):3508-3518 [PubMed]
Almasian M , Bosschaart N, van Leeuwen TG, Faber DJ, Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime. J BIOMED OPT 2015;20 (12):121314 [PubMed]
Bosschaart N, van Leeuwen TG, Aalders MC, Hermann B, Drexler W, Faber DJ. Spectroscopic low coherence interferometry in: Drexler W, Fujimoto JG, editors. Optical Coherence tomography : Technology and Applications, 2nd. edition. Cham: Springer; 2015., p. 1163-1187
Bus MTJ, de Bruin DM, Faber DJ, Kamphuis GM, Zondervan PJ, Laguna Pes MP, de Reijke TM, Traxer O, van Leeuwen TG, de La Rosette JJMCH, Optical diagnostics for upper urinary tract urothelial cancer: technology, thresholds, and clinical applications. J ENDOUROL 2015;29 (2):113-123 [PubMed]
Cernohorsky P, Kok AC, Bruin DMd, Brandt MJ, Faber DJ, Tuijthof GJ, Kerkhoffs GM, Strackee SD, van Leeuwen TG, de Bruin DM, Comparison of optical coherence tomography and histopathology in quantitative assessment of goat talus articular cartilage. ACTA ORTHOP 2015;86 (2):257-263 [PubMed]
Edelman GJ, van Leeuwen TG, Aalders MC, Visualization of latent blood stains using visible reflectance hyperspectral imaging and chemometrics. J FORENSIC SCI 2015;60 (Suppl. 1):S188-S192 [PubMed]
Grundeken MJ, Hassell MECJ, Kraak RP, de Bruin DM, Koch KT, Henriques JPS, van Leeuwen TG, Tijssen JGP, Piek JJ, de Winter RJ, Wykrzykowska JJ, Treatment of coronary bifurcation lesions with the Absorb bioresorbable vascular scaffold in combination with the Tryton dedicated coronary bifurcation stent: evaluation using two- and three-dimensional optical coherence tomography. EUROINTERVENTION 2015;11 (8):877-884 [PubMed]
Heijblom M, Piras D, Brinkhuis M, van Hespen JCG, van den Engh FM, van der Schaaf M, Klaase JM, van Leeuwen TG, Steenbergen W, Manohar S, Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology. SCI REP-UK 2015;5:11778 [PubMed]
Muller BG, de Bruin DM, van den Bos W, Brandt MJ, Velu JF, Bus MTJ, Faber DJ, Savci D, Zondervan PJ, de Reijke TM, Pes PL, de la Rosette J, van Leeuwen TG, Prostate cancer diagnosis: the feasibility of needle-based optical coherence tomography. J MED IMAGING 2015;2 (3):037501 [PubMed]
Nadort A. Glow with the flow: Quantifying blood flow and photoluminescence signal in biological tissue. S.l.: s.n.; 2015. 209p. ISBN 978-94-6182-546-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM, Aalders MCG; copromotor(s): Faber DJ)
Thomas G. Nonlinear optical imaging as a diagnostic tool for cutaneous squamous cell carcinoma. S.l.: s.n.; 2015. 197p. ISBN 9789462594739 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM, Sterenborg HJCM; copromotor(s): Gerritsen HC)
van der Pol E. Detection of extracellular vesicles: size does matter. S.l.: s.n.; 2015. 222p. ISBN 9789462950696 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM, Sturk A; copromotor(s): Nieuwland R)
van Gemert MJC, Wagstaff PGK, de Bruin DM, van Leeuwen TG, van der Wal AC, Heger M, van der Geld CWM, Irreversible electroporation: just another form of thermal therapy?. PROSTATE 2015;75 (3):332-335 [PubMed]
Wagstaff PGK, de Bruin DM, van den Bos W, Ingels A, van Gemert MJC, Zondervan PJ, Verdaasdonk RM, van Lienden KP, van Leeuwen TG, de La Rosette JJMCH, Laguna Pes MP, Irreversible electroporation of the porcine kidney: Temperature development and distribution. UROL ONCOL-SEMIN ORI 2015;33 (4):168.e1-168.e7 [PubMed]
Wagstaff PGK, de Bruin DM, Zondervan PJ, Savci Heijink CD, Engelbrecht MRW, van Delden OM, van Leeuwen TG, Wijkstra H, de La Rosette JJMCH, Laguna Pes MP, The efficacy and safety of irreversible electroporation for the ablation of renal masses: a prospective, human, in-vivo study protocol. BMC CANCER 2015;15 (1):165 [PubMed]
Wagstaff PG, Swaan A, Ingels A, Zondervan PJ, van Delden OM, Faber DJ, van Leeuwen TG, de la Rosette JJ, de Bruin DM, Laguna Pes MP, In vivo, percutaneous, needle based, optical coherence tomography of renal masses. JOVE-J VIS EXP 2015;2015 (97):e52574 [PubMed]
Weiss N, van Leeuwen TG, Kalkman J, Simultaneous and localized measurement of diffusion and flow using optical coherence tomography. OPT EXPRESS 2015;23 (3):3448-3459 [PubMed]
Wessels R. Clinical experiences with optical coherence tomography in epithelial (pre)malignancies. Enschede: Ipskamp Drukkers, Enschede; 2015. 141p. ISBN 978-94-6259-681-8 Proefschrift Universiteit Twente, TNW. (Promotor(s): Ruers TJM, van Leeuwen AGJM; copromotor(s): Faber DJ, van Beurden M)
Wessels R, de Bruin DM, Faber DJ, Horenblas S, van Rhijn BWG, Vincent AD, van Beurden M, van Leeuwen TG, Ruers TJM, Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study. UROL ANNALS 2015;7 (4):459-465 [PubMed]
Wessels R, de Bruin DM, Faber DJ, Sanders J, Vincent AD, van Beurden M, van Leeuwen TG, Ruers TJM, Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient. J BIOMED OPT 2015;20 (12):121313 [PubMed]
Wessels R, de Bruin DM, Relyveld GN, Faber DJ, Vincent AD, Sanders J, van Leeuwen TG, Ruers TJM, Functional optical coherence tomography of pigmented lesions. J EUR ACAD DERMATOL 2015;29 (4):738-744 [PubMed]
Wessels R, van Beurden M, de Bruin DM, Faber DJ, Vincent AD, Sanders J, van Leeuwen TG, Ruers TJM, The value of optical coherence tomography in determining surgical margins in squamous cell carcinoma of the vulva: a single-center prospective study. INT J GYNECOL CANCER 2015;25 (1):112-118 [PubMed]
Bosschaart N, Edelman GJ, Aalders MCG, van Leeuwen TG, Faber DJ, A literature review and novel theoretical approach on the optical properties of whole blood. LASER MED SCI 2014;29 (2):453-479 [PubMed]
Bosschaart N, van Leeuwen TG, Aalders MCG, Faber DJ, Quantitative comparison of analysis methods for spectroscopic optical coherence tomography: reply to comment. BIOMED OPT EXPRESS 2014;5 (9):3034-3035 [PubMed]
Coumans FAW, van der Pol E, Böing AN, Hajji N, Sturk G, van Leeuwen TG, Nieuwland R, Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing. J EXTRACELL VESICLES 2014;3:25922 [PubMed]
de Bruin DM. Clinical applications of functional optical coherence tomography. s.l.: s.n.; 2014. 201p. ISBN 9789462035485 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM, Mourits MP; copromotor(s): Faber DJ, Verbraak FD)
Edelman GJ. Spectral analysis of blood stains at the crime scene. s.l.: s.n.; 2014. 208p. ISBN 9789064647642 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Aalders MCG, van Leeuwen AGJM; copromotor(s): )
Grundeken MJ, Garcia-Garcia HM, Kraak RP, Woudstra P, de Bruin DM, van Leeuwen TG, Koch KT, Tijssen JG, de Winter RJ, Wykrzykowska JJ, Side branch healing patterns of the Tryton dedicated bifurcation stent: a 1-year optical coherence tomography follow-up study. INT J CARDIOVAS IMAG 2014;30 (8):1445-1456 [PubMed]
Heijblom M. Clinical experiences with photoacoustic breast imaging. Universiteit Twente: Gildeprint; 2014. 205p. ISBN 978-90-365-3623-3 Proefschrift Universiteit Twente, Biomed Photonic Imaging Group. (Promotor(s): Steenbergen W, van Leeuwen AGJM; copromotor(s): Manohar S)
Heijblom M, Meijer LM, van Leeuwen TG, Steenbergen W, Manohar S, Monte Carlo simulations shed light on Bathsheba's suspect breast. J BIOPHOTONICS 2014;7 (5):323-331 [PubMed]
Karakullukçu B. New insights into photodynamic therapy of the head and neck. s.l: s.n.; 2014. 190p. ISBN 9789491688041 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam, onderzoek bij Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, -. (Promotor(s): van Leeuwen AGJM, Tan IB; copromotor(s): Sterenborg HJCM, Robinson DJ)
Stehouwer M, Tan SH, van Leeuwen TG, Verbraak FD, Senile retinoschisis versus retinal detachment, the additional value of peripheral retinal OCT scans (SL SCAN-1, Topcon). ACTA OPHTHALMOL 2014;92 (3):221-227 [PubMed]
van Dam A. Fingermarks, more than just a ridge pattern. S.l.: s.n.; 2014. 229p. ISBN 9789088919183 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Aalders MCG, van Leeuwen AGJM; copromotor(s): Lambrechts SAG)
van Dam A, Aalders MCG, de Puit M, Gorré SM, Irmak D, van Leeuwen TG, Lambrechts SAG, Immunolabeling and the compatibility with a variety of fingermark development techniques. SCI JUSTICE 2014;54 (5):356-362 [PubMed]
van Dam A, Schwarz JCV, de Vos J, Siebes M, Sijen T, van Leeuwen TG, Aalders MCG, Lambrechts SAG, Oxidation monitoring by fluorescence spectroscopy reveals the age of fingermarks. ANGEW CHEM INT EDIT 2014;53 (24):6272-6275 [PubMed]
van Dam A, van Nes KA, Aalders MCG, van Leeuwen TG, Lambrechts SAG, Immunolabeling of fingermarks left on forensic relevant surfaces, including thermal paper. ANAL METHODS-UK 2014;6 (4):1051-1058
van der Pol E, Coumans FAW, Grootemaat AE, Gardiner C, Sargent IL, Harrison P, Sturk A, van Leeuwen TG, Nieuwland R, Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J THROMB HAEMOST 2014;12 (7):1182-1192 [PubMed]
van der Pol E, Coumans FAW, Sturk A, Nieuwland R, van Leeuwen TG, Refractive Index Determination of Nanoparticles in Suspension Using Nanoparticle Tracking Analysis. NANO LETT 2014;14 (11):6195-6201 [PubMed]
Wessels R, de Bruin DM, Faber DJ, van Leeuwen TG, van Beurden M, Ruers TJM, Optical biopsy of epithelial cancers by optical coherence tomography (OCT). LASER MED SCI 2014;29 (3):1297-1305 [PubMed]
Yurtsever G, Weiss N, Kalkman J, van Leeuwen TG, Baets R, Ultra-compact silicon photonic integrated interferometer for swept-source optical coherence tomography. OPT LETT 2014;39 (17):5228-5231 [PubMed]
Bosschaart N, van Leeuwen TG, Aalders MCG, Faber DJ, Quantitative comparison of analysis methods for spectroscopic optical coherence tomography. BIOMED OPT EXPRESS 2013;4 (11):2570-2584 [PubMed]
Bremmer RH, van Gemert MJC, Faber DJ, van Leeuwen TG, Aalders MCG, Diffuse reflectance relations based on diffusion dipole theory for large absorption and reduced scattering. J BIOMED OPT 2013;18 (8):87007 [PubMed]
Bus MTJ, Muller BG, de Bruin DM, Faber DJ, Kamphuis GM, van Leeuwen TG, de Reijke TM, de La Rosette JJMCH, Volumetric in vivo visualization of upper urinary tract tumors using optical coherence tomography: a pilot study. J UROLOGY 2013;190 (6):2236-2242 [PubMed]
de Kinkelder R, de Bruin DM, Verbraak FD, van Leeuwen TG, Faber DJ, Comparison of retinal nerve fiber layer thickness measurements by spectral-domain optical coherence tomography systems using a phantom eye model. J BIOPHOTONICS 2013;6 (4):314-320 [PubMed]
Edelman GJ, Hoveling RJM, Roos M, van Leeuwen TG, Aalders MCG, Infrared imaging of the crime scene: possibilities and pitfalls. J FORENSIC SCI 2013;58 (5):1156-1162 [PubMed]
Grootendorst DJ, Jose J, Fratila RM, Visscher M, Velders AH, ten Haken B, van Leeuwen TG, Steenbergen W, Manohar S, Ruers TJM, Evaluation of superparamagnetic iron oxide nanoparticles (Endorem®) as a photoacoustic contrast agent for intra-operative nodal staging. CONTRAST MEDIA MOL I 2013;8 (1):83-91 [PubMed]
Hassell MECJ, Grundeken MJ, de Bruin DM, van de Hoef TP , van Leeuwen TG, Henriques JPS, Piek JJ, Wykrzykowska JJ, Successful treatment of a long tapered lesion with two overlapping ABSORB bioresorbable vascular scaffolds of different diameters: evaluation by three-dimensional optical coherence tomography. INT J CARDIOL 2013;165 (2):e26-e27 [PubMed]
Holz JA, Boerwinkel DF, Meijer SL, Visser M , van Leeuwen TG, Aalders MCG, Bergman JJGHM, Optimized endoscopic autofluorescence spectroscopy for the identification of premalignant lesions in Barrett's oesophagus. EUR J GASTROEN HEPAT 2013;25 (12):1442-1449 [PubMed]
Nadort A, Woolthuis RG, van Leeuwen TG, Faber DJ, Quantitative laser speckle flowmetry of the in vivo microcirculation using sidestream dark field microscopy. BIOMED OPT EXPRESS 2013;4 (11):2347-2361 [PubMed]
Nguyen DV. Integrated-optics-based optical coherence tomography. s.l.: s.n.; 2013. 132p. ISBN 9789461823359 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM; copromotor(s): Kalkman J)
Nguyen VD, Faber DJ, van der Pol E, van Leeuwen TG, Kalkman J, Dependent and multiple scattering in transmission and backscattering optical coherence tomography. OPT EXPRESS 2013;21 (24):29145-29156 [PubMed]
Ungureanu C, Koning GA, van Leeuwen TG, Manohar S, The 'nanobig rod' class of gold nanorods: optimized dimensions for improved in vivo therapeutic and imaging efficacy. NANOTECHNOLOGY 2013;24 (21):215102 [PubMed]
van Dam A, Aalders MCG, van de Braak K, Hardy HJJ, van Leeuwen TG, Lambrechts SAG, Simultaneous labeling of multiple components in a single fingermark. FORENSIC SCI INT 2013;232 (1-3):173-179 [PubMed]
van Dam A, Aalders MCG, van Leeuwen TG, Lambrechts SAG, The compatibility of fingerprint visualization techniques with immunolabeling. J FORENSIC SCI 2013;58 (4):999-1002 [PubMed]
Weiss N, van Leeuwen TG, Kalkman J, Localized measurement of longitudinal and transverse flow velocities in colloidal suspensions using optical coherence tomography. PHYS REV E 2013;88 (4 Part 1):042312 [PubMed]
Xia W. Optimized ultrasounddetection for sensitive 3D photoacoustic breast tomography. Enschede: Boxpress 's Hertogenbosch; 2013. 149p. ISBN 978 90 365 12169 Proefschrift Universiteit Twente, Biomedical Photonic Imaging. (Promotor(s): Steenbergen W, van Leeuwen AGJM; copromotor(s): Manohar S)
Xia W, Piras D, Singh MKA, van Hespen JCG, van Leeuwen TG, Steenbergen W, Manohar S, Design and evaluation of a laboratory prototype system for 3D photoacoustic full breast tomography. BIOMED OPT EXPRESS 2013;4 (11):2555-2569 [PubMed]
Xia W, Piras D, van Hespen JCG, van Veldhoven S, Prins C, van Leeuwen TG, Steenbergen W, Manohar S, An optimized ultrasound detector for photoacoustic breast tomography. MED PHYS 2013;40 (3):032901 [PubMed]
Akca BI, Nguyen VD, Kalkman J, Ismail N, Sengo G, Sun F, Driessen A, van Leeuwen TG, Pollnau M, Worhoff K, de Ridder RM, Toward Spectral-Domain Optical Coherence Tomography on a Chip. IEEE J SEL TOP QUANT 2012;18 (3):1223-1233
Barwari K, de Bruin DM, Faber DJ, van Leeuwen TG, de la Rosette JJ, Laguna MP, Differentiation between normal renal tissue and renal tumours using functional optical coherence tomography: a phase I in vivo human study. BJU INT 2012;110 (8B):E415-E420 [PubMed]
Bosschaart N. Quantitative and localized spectroscopy for non-invasive bilirubinometry in neonates. s.l.: s.n.; 2012. 108p. ISBN 9789461820655 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM; copromotor(s): Aalders MCG)
Bosschaart N, Aalders MCG, van Leeuwen TG, Faber DJ, Spectral domain detection in low-coherence spectroscopy. BIOMED OPT EXPRESS 2012;3 (9):2263-2272 [PubMed]
Bosschaart N, Kok JH, Newsum AM, Ouweneel DM, Mentink R, van Leeuwen TG, Aalders MCG, Limitations and Opportunities of Transcutaneous Bilirubin Measurements. PEDIATRICS 2012;129 (4):689-694 [PubMed]
Bremmer RH, de Bruin KG, van Gemert MJC, van Leeuwen TG, Aalders MCG, Forensic quest for age determination of bloodstains. FORENSIC SCI INT 2012;216 (1-3):1-11 [PubMed]
Cernohorsky P, de Bruin DM, van Herk M, Bras J, Faber DJ, Strackee SD, van Leeuwen TG, In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography. J BIOMED OPT 2012;17 (6):060501 [PubMed]
de Kinkelder R. Optical diagnostic techniques in ophthalmology. s.l.: s.n.; 2012. 127p. ISBN 9789462031692 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM; copromotor(s): Verbraak FD, Faber DJ)
de Kinkelder R, van Leeuwen TG, Verbraak FD, Detection of early-stage age related macular degeneration with a compact rarebit test. BRIT J OPHTHALMOL 2012;96 (10):1354-1355 [PubMed]
Edelman GJ, Gaston E, van Leeuwen TG, Cullen PJ, Aalders MCG, Hyperspectral imaging for non-contact analysis of forensic traces. FORENSIC SCI INT 2012;223 (1-3):28-39 [PubMed]
Edelman G, Manti V, van Ruth SM, van Leeuwen T, Aalders M, Identification and age estimation of blood stains on colored backgrounds by near infrared spectroscopy. FORENSIC SCI INT 2012;220 (1-3):239-244 [PubMed]
Edelman G, van Leeuwen TG, Aalders MCG, Hyperspectral imaging for the age estimation of blood stains at the crime scene. FORENSIC SCI INT 2012;223 (1-3):72-77 [PubMed]
Grootendorst DJ, Jose J, Wouters MW, van Boven H, van der Hage J, van Leeuwen TG, Steenbergen W, Manohar S, Ruers TJM, First experiences of photoacoustic imaging for detection of melanoma metastases in resected human lymph nodes. LASER SURG MED 2012;44 (7):541-549 [PubMed]
Hartsuiker L, Petersen W, Rayavarapu RG, Lenferink A, Poot AA, Terstappen LWMM, van Leeuwen TG, Manohar S, Otto C, Raman and Fluorescence Spectral Imaging of Live Breast Cancer Cells Incubated with PEGylated Gold Nanorods. APPL SPECTROSC 2012;66 (1):66-74
Heijblom M, Piras D, Xia W, van Hespen JCG, Klaase JM, van den Engh FM, van Leeuwen TG, Steenbergen W, Manohar S, Visualizing breast cancer using the Twente photoacoustic mammoscope: What do we learn from twelve new patient measurements?. OPT EXPRESS 2012;20 (11):11582-11597 [PubMed]
Jose J. Prospects of Passive element enRiched Photoacoustic Computerd Tomography (PER-PACT). Enschede: s.n.; 2012. 159p. ISBN 978-90-365-3347-8 Proefschrift Universiteit Twente, Faculty of Science & Technol., Biomed.Photonic Imaging Group (BMPI). (Promotor(s): van Leeuwen AGJM; copromotor(s): Manohar S)
Jose J, Willemink RGH, Steenbergen W, Slump CH, van Leeuwen TG, Manohar S, Speed-of-sound compensated photoacoustic tomography for accurate imaging. MED PHYS 2012;39 (12):7262-7271 [PubMed]
Kalkman J, Bykov AV, Streekstra GJ, van Leeuwen TG, Multiple scattering effects in Doppler optical coherence tomography of flowing blood. PHYS MED BIOL 2012;57 (7):1907-1917 [PubMed]
Kodach VM. Development of functional near-infrared optical coherence tomography. s.l.: s.n.; 2012. 114p. ISBN 9789461820815 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM; copromotor(s): Kalkman J, Faber DJ)
Leproux A. Breast lesion detection using diffuse optical imaging. s.l.: s.n.; 2012. 143p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM, Tromberg BJ; copromotor(s): van der Voort M, Cerussi AE)
Nguyen VD, Weiss N, Beeker W, Hoekman M, Leinse A, Heideman RG, van Leeuwen TG, Kalkman J, Integrated-optics-based swept-source optical coherence tomography. OPT LETT 2012;37 (23):4820-4822 [PubMed]
Stam B. Three dimensional modeling of bruise evolution for improved age determination. s.l.: s.n.; 2012. 139p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM, van Gemert MJC; copromotor(s): Aalders MCG)
Stam B, van Gemert MJC, van Leeuwen TG, Aalders MCG, How the blood pool properties at onset affect the temporal behavior of simulated bruises. MED BIOL ENG COMPUT 2012;50 (2):165-171 [PubMed]
van der Pol E, van Gemert MJC, Sturk A, Nieuwland R, van Leeuwen TG, Single vs. swarm detection of microparticles and exosomes by flow cytometry. J THROMB HAEMOST 2012;10 (5):919-930 [PubMed]
van Es P, van Leeuwen AGJM, Steenbergen W, Manohar S. Multimodal Photoacoustic and Ultrasound Imaging in: Anastasio MA, La Riviere P, editors. Emerging imaging technologies in medicine. S.l.: CRC; 2012., p. 233-252
Weiss N, van Leeuwen TG, Kalkman J, Doppler-based lateral motion tracking for optical coherence tomography. OPT LETT 2012;37 (12):2220-2222 [PubMed]
Wessels R, de Bruin DM, Faber DJ, van Boven HH, Vincent AD, van Leeuwen TG, van Beurden M, Ruers TJM, Optical coherence tomography in vulvar intraepithelial neoplasia. J BIOMED OPT 2012;17 (11):116022 [PubMed]
Barwari K, de Bruin DM, Cauberg ECC, Faber DJ, van Leeuwen TG, Wijkstra H, de la Rosette J, Laguna MP, Advanced diagnostics in renal mass using optical coherence tomography: a preliminary report. J ENDOUROL 2011;25 (2):311-315 [PubMed]
Barwari K, de Bruin DM, Faber DJ, van Leeuwen TG, de la Rosette JJ, Laguna MP, New optical diagnostic tools in renal cell cancer. MINERVA UROL NEFROL 2011;63 (3):213-225 [PubMed]
Bosschaart N, Faber DJ, Leeuwen TGv, Aalders MCG, Measurements of wavelength dependent scattering and backscattering coefficients by low-coherence spectroscopy. J BIOMED OPT 2011;16 (3):030503 [PubMed]
Bosschaart N, Faber DJ, van Leeuwen TG, Aalders MCG, In vivo low-coherence spectroscopic measurements of local hemoglobin absorption spectra in human skin. J BIOMED OPT 2011;16 (10):100504 [PubMed]
Bosschaart N, Mentink R, Kok JH, van Leeuwen TG, Aalders MCG, Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation. J BIOMED OPT 2011;16 (9):097003 [PubMed]
Bratchenia A, Molenaar R, van Leeuwen TG, Kooyman RPH, Acousto-optic-assisted diffuse optical tomography. OPT LETT 2011;36 (9):1539-1541 [PubMed]
Bremmer RH. Non-contact spectroscopic age ddetermination of bloodstains. s.l.: s.n.; 2011. 147p. ISBN 9789490371975 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM; copromotor(s): Aalders MCG)
Bremmer RH, de Bruin DM, de Joode M, Buma WJ, van Leeuwen TG, Aalders MCG, Biphasic oxidation of oxy-hemoglobin in bloodstains. PLOS ONE 2011;6 (7):e21845 [PubMed]
Bremmer RH, Kanick SC, Laan N, Amelink A, van Leeuwen TG, Aalders MCG, Non-contact spectroscopic determination of large blood volume fractions in turbid media. BIOMED OPT EXPRESS 2011;2 (2):396-407 [PubMed]
Bremmer RH, Nadort A, van Leeuwen TG, van Gemert MJC, Aalders MCG, Age estimation of blood stains by hemoglobin derivative determination using reflectance spectroscopy. FORENSIC SCI INT 2011;206 (1-3):166-171 [PubMed]
de Kinkelder R, Kalkman J, Faber DJ, Schraa O, Kok PHB, Verbraak FD, van Leeuwen TG, Heartbeat-Induced Axial Motion Artifacts in Optical Coherence Tomography Measurements of the Retina. INVEST OPHTH VIS SCI 2011;52 (6):3908-3913 [PubMed]
de Kinkelder R, van der Veen RLP, Verbaak FD, Faber DJ, van Leeuwen TG, Berendschot TTJM, Macular pigment optical density measurements: evaluation of a device using heterochromatic flicker photometry. EYE 2011;25 (1):105-112 [PubMed]
Faber DJ, van Leeuwen TG. Optical Coherence Tomography in: Welch AJ, van Gemert MJC, editors. Optical-Thermal Response of Laser-Irradiated Tissue. London New York: Springer; 2011. chapter 18, p. 713-741
Hartsuiker L. Microspectroscopic characterization of gold nanorods for cander cell detection. Enschede: Gildeprint; 2011. 166p. ISBN 978-90-365-3240-2 Proefschrift Universiteit Twente, Tu Twente -Biomedical Photonic Imaging, onderzoek in AMC-UvA. (Promotor(s): Terstappen LWMM, van Leeuwen TG; copromotor(s): Otto C)
Hartsuiker L, van Es P, Petersen W, van Leeuwen TG, Terstappen LWMM, Otto C, Quantitative detection of gold nanoparticles on individual, unstained cancer cells by scanning electron microscopy. J MICROSC-OXFORD 2011;244 (2):187-193 [PubMed]
Heijblom M, Klaase JM, van den Engh FM, van Leeuwen TG, Steenbergen W, Manohar S, Imaging tumor vascularization for detection and diagnosis of breast cancer. TECHNOL CANCER RES T 2011;10 (6):607-623 [PubMed]
Jose J, Grootendorst DJ, Vijn TW, Wouters MW, van Boven H, van Leeuwen TG, Steenbergen W, Ruers TJM, Manohar S, Errata: Initial results of imaging melanoma metastasis in resected human lymph nodes using photoacoustic computed tomography. J BIOMED OPT 2011;16 (11):119801 [PubMed]
Jose J, Grootendorst DJ, Vijn TW, Wouters MW, Wouters M, van Boven H, van Leeuwen TG, Steenbergen W, Ruers TJM, Manohar S, Initial results of imaging melanoma metastasis in resected human lymph nodes using photoacoustic computed tomography. J BIOMED OPT 2011;16 (9):096021 [PubMed]
Jose J, Willemink RGH, Resink S, Piras D, van Hespen JCG, Slump CH, Steenbergen W, van Leeuwen TG, Manohar S, Passive element enriched photoacoustic computed tomography (PER PACT) for simultaneous imaging of acoustic propagation properties and light absorption. OPT EXPRESS 2011;19 (3):2093-2104 [PubMed]
Kodach VM, Faber DJ, van Marle J, van Leeuwen TG, Kalkman J, Determination of the scattering anisotropy with optical coherence tomography. OPT EXPRESS 2011;19 (7):6131-6140 [PubMed]
Lankveld DP, Rayavarapu RG, Krystek P, Oomen AG, Verharen HW, van Leeuwen TG, de Jong WH, Manohar S, Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats. NANOMED-NANOTECHNOL 2011;6 (2):339-349 [PubMed]
Leproux A, van der Voort M, van der Mark MB, Harbers R, van de Ven SMWY, van Leeuwen TG, Optical mammography combined with fluorescence imaging: lesion detection using scatterplots. BIOMED OPT EXPRESS 2011;2 (4):1007-1020 [PubMed]
Manohar S, Ungureanu C, van Leeuwen TG, Gold nanorods as molecular contrast agents in photoacoustic imaging: the promises and the caveats. CONTRAST MEDIA MOL I 2011;6 (5):389-400 [PubMed]
Nguyen VD, Akca BI, Wörhoff K, de Ridder RM, Pollnau M, van Leeuwen TG, Kalkman J, Spectral domain optical coherence tomography imaging with an integrated optics spectrometer. OPT LETT 2011;36 (7):1293-1295 [PubMed]
Patil CA, Kalkman J, Faber DJ, Nyman JS, van Leeuwen TG, Mahadevan-Jansen A, Integrated system for combined Raman spectroscopy-spectral domain optical coherence tomography. J BIOMED OPT 2011;16 (1):011007 [PubMed]
Patil CA, Kirshnamoorthi H, Ellis DL, van Leeuwen TG, Mahadevan-Jansen A, A Clinical Instrument for Combined Raman Spectroscopy-Optical Coherence Tomography of Skin Cancers. LASER SURG MED 2011;43 (2):143-151 [PubMed]
Resink S, Jose J, Willemink RGH, Slump CH, Steenbergen W, van Leeuwen TG, Manohar S, Multiple passive element enriched photoacoustic computed tomography. OPT LETT 2011;36 (15):2809-2811 [PubMed]
Stam B, van Gemert MJC, van Leeuwen TG, Teeuw AH, van der Wal AC, Aalders MCG, Can color inhomogeneity of bruises be used to establish their age?. J BIOPHOTONICS 2011;4 (10):759-767 [PubMed]
Stehouwer M, Verbraak FD, de Vries HR, van Leeuwen TG, Scanning beyond the limits of standard OCT with a Fourier domain optical coherence tomography integrated into a slit lamp: the SL SCAN-1. EYE 2011;25 (1):97-104 [PubMed]
Ungureanu C, Kroes R, Petersen W, Groothuis TAM, Ungureanu F, Janssen H, van Leeuwen FWB, Kooyman RPH, Manohar S, van Leeuwen TG, Light interactions with gold nanorods and cells: implications for photothermal nanotherapeutics. NANO LETT 2011;11 (5):1887-1894 [PubMed]
Walsh JT, van Leeuwen TG, Duco Jansen E, Motamedi M, Welch AJ. Pulsed Laser Tissue Interaction in: Welch AJ, van Gemert MJC, editors. Optical-Thermal Response of Laser-Irradiated Tissue. London New York: Springer; 2011. chapter 15, p. 617-649
Xia W, Piras D, Heijblom M, Steenbergen W, van Leeuwen TG, Manohar S, Poly(vinyl alcohol) gels as photoacoustic breast phantoms revisited. J BIOMED OPT 2011;16 (7):075002 [PubMed]
Akca I, Ismail N, Sun F, Nguyen D, Kalkman J, van Leeuwen T, Driessen A, Worhoff K, Pollnau M, de Ridder R, Integrated Arrayed Waveguide Grating Spectrometer for On-Chip Optical Coherence Tomography. BIOMED OPTICS 2010;2010:JWA66
Bosschaart N, Aalders M, Faber D, van Leeuwen T, Measurements of Wavelength Dependent Scattering Coefficients by Low Coherence Spectroscopy. BIOMED OPTICS 2010;2010:BTuD30
Bratchenia A. Towards quantitative acoustic-optic imaging. Enschede: s.n.; 2010. 148p. ISBN 978-90-365-3059-0 Proefschrift Universiteit Twente, Biomedische Techniek. (Promotor(s): van Leeuwen AGJM; copromotor(s): Kooijman GC)
Cauberg ECC, de Bruin DM, Faber DJ, de Reijke TM, Visser M , de La Rosette JJMCH, van Leeuwen TG, Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder. J BIOMED OPT 2010;15 (6):066013-066013-6 [PubMed]
de Bruin DM, Bremmer RH, Kodach VM, de Kinkelder R, van Marle J, van Leeuwen TG, Faber DJ, Optical phantoms of varying geometry based on thin building blocks with controlled optical properties. J BIOMED OPT 2010;15 (2):025001 [PubMed]
Draijer M. High-speed perfusion imaging based on laser speckle fluctuations. Enschede: s.n.; 2010. 135p. ISBN 978-90-365-2979-2 Proefschrift Universiteit Twente, Biomedische Techniek. (Promotor(s): van Leeuwen AGJM; copromotor(s): Steenbergen W)
Draijer MJ, Hondebrink E, Larsson M, van Leeuwen TG, Steenbergen W, Relation between the contrast in time integrated dynamic speckle patterns an the power spectral density of their temporal intensity fluctuations. OPT EXPRESS 2010;18 (21):21883-21891 [PubMed]
Jose J, Willemink R, Resink S, Piras D, van Hespen J, van Leeuwen T, Manohar S, Simultaneous Imaging of Speed-of-Sound, Acoustic Attenuation and Optical Absorption Using a Computed Tomography Photoacoustic Imager. BIOMED OPTICS 2010;2010:BsuD5
Kalkman J, Bykov AV, Faber DJ, van Leeuwen TG, Multiple and dependent scattering effects in Doppler optical coherence tomography. OPT EXPRESS 2010;18 (4):3883-3892 [PubMed]
Kalkman J, Bykov AV, Faber D, van Leeuwen T, Multiple Scattering Effects in Intralipid and Whole Blood Measured with Doppler Optical Coherence Tomography. BIOMED OPTICS 2010;2010:BTuD17
Kalkman J, Sprik R, van Leeuwen TG, Path-length-resolved diffusive particle dynamics in spectral-domain optical coherence tomography. PHYS REV LETT 2010;105 (19):198302 [PubMed]
Kodach V, Bosschaart N, Kalkman J, van Leeuwen T, Faber D, Concentration Dependent Scattering Coefficients of Intralipid Measured with OCT. BIOMED OPTICS 2010;2010:BSuD11
Kodach VM, Kalkman J, Faber DJ, van Leeuwen TG, Quantitative comparison of the OCT imaging depth at 1300 nm and 1600 nm. BIOMED OPT EXPRESS 2010;1 (1):176-185 [PubMed]
Kolkman RGM, Blomme E, Cool T, Bilcke M, van Leeuwen TG, Steenbergen W, Grimbergen KA, den Heeten GJ, Feasibility of noncontact piezoelectric detection of photoacoustic signals in tissue-mimicking phantoms. J BIOMED OPT 2010;15 (5):055011 [PubMed]
Nguyen VD, Ismael N, Sun F, Worhoff K, van Leeuwen TG, Kalkman J, Sion Integrated optics elliptic couplers for Fizeau-based optical coherence tomography. J LIGHTWAVE TECHNOL 2010;28 (19):2836-2842
Patil CA, Kalkman J, Faber D, Penn JS, van Leeuwen TG, Mahadevan-Jansen A. Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-spectral domain optical coherence tomography (RS-SDOCT) in: Manns F, Söderberg PG, Ho A, editors. Ophthalmic technologies XX. S.l.: s.n.; 2010., p. 778965
Piras D, Xia W, Steenbergen W, van Leeuwen TG, Manohar S, Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives. IEEE J SEL TOP QUANT 2010;16 (4):730-739
Rayavarapu RG. Gold nanorods as molecular probes for light-based imaging techniques. Enschede: s.n.; 2010. 148p. ISBN 978-90-365-2994-5 Proefschrift Universiteit Twente, Biomedische Techniek. (Promotor(s): van Leeuwen AGJM; copromotor(s): Manohar S)
Rayavarapu RG, Petersen W, Hartsuiker L, Chin P, Janssen H, van Leeuwen FWB, Otto C, Manohar S, van Leeuwen TG, In vitro toxicity studies of polymer-coated gold nanorods. NANOTECHNOLOGY 2010;21 (14):145101 [PubMed]
Rayavarapu RG, Ungureanu C, Krystek P, van Leeuwen TG, Manohar S, Iodide impurities in hexadecyltrimethylammonium bromide (CTAB) products: lot-lot variations and influence on gold nanorod synthesis. LANGMUIR 2010;26 (7):5050-5055 [PubMed]
Stam B, van Gemert MJC, van Leeuwen TG, Aalders MCG, 3D finite compartment modeling of formation and healing of bruises may identify methods for age determination of bruises. MED BIOL ENG COMPUT 2010;48 (9):911-921 [PubMed]
Steenbergen W, Hondebrink E, van Leeuwen TG, Draijer MJ, editors, Dynamics and fluctiations in biomedical photonics VII. S.l.: s.n.; 2010. -p. (Proceedings of SPIE; 7563)
Stehouwer M, Verbraak FD, de Vries H, Kok PHB, van Leeuwen TG, Fourier Domain Optical Coherence Tomography integrated into a slit lamp; a novel technique combining anterior and posterior segment OCT. EYE 2010;24 (6):980-984 [PubMed]
Ungureanu C. Interactions of light with gold nanorods and cells. Enschede: Wohrmann Print Service Zutphen; 2010. 160p. ISBN 978-90-365-3079-8 Proefschrift University of Twente, Biomedical Photonic Imaging Group, Faculty of Science & Technology. (Promotor(s): van Leeuwen TG; copromotor(s): Manohar S)
Ungureanu C, Amelink A, Rayavarapu RG, Sterenborg HJCM, Manohar S, van Leeuwen TG, Differential Pathlength Spectroscopy for the Quantitation of Optical Properties of Gold Nanoparticles. ACS NANO 2010;4 (7):4081-4089 [PubMed]
van der Meer FJ, Faber DJ, Aalders MCG, Poot AA, Vermes I, van Leeuwen TG, Apoptosis- and necrosis-induced changes in light attenuation measured by optical coherence tomography. LASER MED SCI 2010;25 (2):259-267 [PubMed]
van der Pol E, Hoekstra AG, Sturk A, Otto C, van Leeuwen TG, Nieuwland R, Optical and non-optical methods for detection and characterization of microparticles and exosomes. J THROMB HAEMOST 2010;8 (12):2596-2607 [PubMed]
van Herpt H, Draijer M, Hondebrink E, Nieuwenhuis M, Beerthuizen G, van Leeuwen T, Steenbergen W, Burn imaging with a whole field laser Doppler perfusion imager based on a CMOS imaging array. BURNS 2010;36 (3):389-396 [PubMed]
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, In Vivo Optical Path Lengths and Path Length Resolved Doppler Shifts of Multiply Scattered Light. LASER SURG MED 2010;42 (9):692-700 [PubMed]
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, Measurement of particle flux in a static matrix with suppressed influence of optical properties, using low coherence interferometry. OPT EXPRESS 2010;18 (3):2849-2857 [PubMed]
Bosschaart N, Aalders MC, Faber DJ, Weda JJ, van Gemert MJ, van Leeuwen TG, Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy. OPT LETT 2009;34 (23):3746-3748 [PubMed]
Bratchenia A, Molenaar R, van Leeuwen TG, Kooyman RPH, Errata: Millimeter-resolution acousto-optic quantitative imaging in a tissue model system. J BIOMED OPT 2009;14 (4):049802 [PubMed]
Bratchenia A, Molenaar R, van Leeuwen TG, van Leewen T, Kooyman RPH, Millimeter-resolution acousto-optic quantitative imaging in a tissue model system. J BIOMED OPT 2009;14 (3):034031 [PubMed]
Cauberg ECC, de Bruin DM, Faber DJ, van Leeuwen TG, de La Rosette JJMCH, de Reijke TM, A new generation of optical diagnostics for bladder cancer: technology, diagnostic accuracy, and future applications. EUR UROL 2009;56 (2):287-296 [PubMed]
Draijer M, Hondebrink E, van Leeuwen T, Steenbergen W, Review of laser speckle contrast techniques for visualizing tissue perfusion. LASER MED SCI 2009;24 (4):639-651 [PubMed]
Draijer M, Hondebrink E, van Leeuwen T, Steenbergen W, Time domain algorithm for accelerated determination of the first order moment of photo current fluctuations in high speed laser Doppler perfusion imaging. MED BIOL ENG COMPUT 2009;47 (10):1103-1109 [PubMed]
Draijer M, Hondebrink E, van Leeuwen T, Steenbergen W, Twente Optical Perfusion Camera: system overview and performance for video rate laser Doppler perfusion imaging. OPT EXPRESS 2009;17 (5):3211-3225 [PubMed]
Faber DJ, van Leeuwen TG, Are quantitative attenuation measurements of blood by optical coherence tomography feasible?. OPT LETT 2009;34 (9):1435-1437 [PubMed]
Faber DJ, van Leeuwen TG, Doppler calibration method for Spectral Domain OCT spectrometers. J BIOPHOTONICS 2009;2 (6-7):407-415 [PubMed]
Jose J, Manohar S, Kolkman RGM, Steenbergen W, van Leeuwen TG, Imaging of tumor vasculature using Twente photoacoustic systems. J BIOPHOTONICS 2009;2 (12):701-717 [PubMed]
Kolkman RGM, van Leeuwen TG, Steenbergen W. Photoacoustic Imaging with a double-Ring Sensor in: Wang LV, editor. Photoacoustic Imaging and Spectroscopy. Boca Raton: CRC Press; 2009., p. 183-200
Manohar S, van Leeuwen TG, Klaasse JM, van den Engh FM, Steenbergen W. Photoacoustic Mammography with a Flat Detection Geometry in: Wang LV, editor. Photoacoustic Imaging and Spectroscopy. Boca Raton: CRC Press; 2009., p. 431-442
Rajan V, Varghese B, van Leeuwen TG, Steenbergen W, Review of methodological developments in laser Doppler flowmetry. LASER MED SCI 2009;24 (2):269-283 [PubMed]
Ungureanu C, Rayavarapu RG, Manohar S, van Leeuwen TG, Discrete dipole approximation simulations of gold nanorod optical properties: Choice of input parameters and comparison with experiment. J APPL PHYS 2009;105 (10):102032
Braaf B, Nadort A, Faber DJ, ter Wee R, van Leeuwen TG, Aalders MCG. Blood oxygen saturation of frozen tissue determined by hyper spectral imaging in: Farkas DL, Nicolau DV, Leif RC, editors. Imaging Manupulation & Analysis of Biomolecules, cells and tissue VI. S.l.: s.n.; 2008. 6859, p. 1-2
Draijer MJ, Hondebrink E, van Leeuwen TG, Steenbergen W, editors, Connecting laser Doppler perfusion imaging and laser speckle contrast analysis in GL Cote & AV Priezzhev (eds.). S.l.: s.n.; 2008. -p. (SPIE Conference Proceedings; 68630C)
Faber DJ, Aalders MCG, Drexler W, van Leeuwen TG. Using Low Coherent Light for Spectroscopic Information from Tissue in: Drexler W, Fujimoto JG, editors. Optical Coherence Tomography : Technology and Applications. Heidelberg: Springer; 2008., p. -
Kodach VM, Faber DJ, van Leeuwen TG, Wavelength swept Ti : sapphire laser. OPT COMMUN 2008;281 (19):4975-4978
Kolkman RGM, Brands PJ, Steenbergen W, van Leeuwen TG, Real-time in vivo photoacoustic and ultrasound imaging. J BIOMED OPT 2008;13 (5):050510 [PubMed]
Kolkman RGM, Mulder MJ, Glade CP, Steenbergen W, van Leeuwen TG, Photoacoustic imaging of port-wine stains. LASER SURG MED 2008;40 (3):178-182 [PubMed]
Kolkman RGM, Thumma KK, ten Brinke GA, Siphanto RI, van Neck H, Steenbergen W, van Leeuwen TG. Photoacoustic imaging of tumor angiogenesis in: Oarevsky AA, Wang LV, editors. Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. S.l.: s.n.; 2008., p. 761214
Manohar S, Kharine A, de Vos C, van Hespen JCG, Steenbergen W, van Leeuwen TG, editors, The Twente Photoacoustic Mammascope: Toward Clinical Trials; In:Emerging Technology in Breast Imaging and Mammography.. Stevenson Ranch CA USA: American Scientific Publishers; 2008. pp.243-274p. (Emerging Technology in Breast Imaging and Mammography.J.S. Suri, R. Rangayyan & S. Laxminarayan (eds.); )
Manohar S, Willemink RG, van Hespen JC, van Leeuwen TG, Hybrid photoacoustic - ultrasound transmission parameter imaging in a miniature photoacoustic imager. J ACOUST SOC AM 2008;123 (5):3371
Patil CA, Bosschaart N, Keller MD, van Leeuwen TG, Mahadevan-Jansen A, Combined Raman spectroscopy and optical coherence tomography device for tissue characterization. OPT LETT 2008;33 (10):1135-1137 [PubMed]
Rajan V, Varghese B, van Leeuwen TG, Steenbergen W, Influence of tissue optical properties on laser Doppler perfusion imaging, accounting for photon penetration depth and the laser speckle phenomenon. J BIOMED OPT 2008;13 (2):024001 [PubMed]
Rajan V, Varghese B, van Leeuwen TG, Steenbergen W, Speckle size and decorrelation time; space-time correlation analysis of coherent light dynamically scattered from turbid media. OPT COMMUN 2008;281 (6):1755-1760
Rolf MP, ter Wee R, van Leeuwen TG, Spaan JAE, Streekstra GJ, Diameter measurement from images of fluorescent cylinders embedded in tissue. MED BIOL ENG COMPUT 2008;46 (6):589-596 [PubMed]
Thumma KK. Photoacoustics for Biomedical Applications: Imaging of tumor vascularization and all-optical detection. Enschede: s.n.; 2008. 115p. Proefschrift Universiteit Twente, Biofys.Techniek. (Promotor(s): van Leeuwen AGJM; copromotor(s): Steenbergen W)
Ungureanu C, van Weperen T, Sijl J, Rayavarapu R, Manohar S, Versluis M, van Leeuwen TG, Acoustic signals from gold nanoparticles irradiated with pulsed lasers. J ACOUST SOC AM 2008;123 (5):3370
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, High angle phase modulated low coherence interferometry for path length resolved Doppler measurements of multiply scattered light. OPT COMMUN 2008;281 (3):494-498
Willemink GH, Manohar S, van der Heijden F, Slump CH, van Leeuwen TG, editors, Imaging of acoustic attenuation and speed of sound maps using photoacoustic measurement.. S.l.: Proc SPIE 692013; 2008. -p. (Medical Imaging 2008, Ultrasonic Imaging & Signal Processing; 692013)
Willemink RG, Manohar S, Slump KH, van der Heijden F, van Leeuwen TG, A maximum likelihood method for obtaining integrated attenuation from ultrasound transmission mode measurements. J ACOUST SOC AM 2008;123 (5):3641
Draijer MJ, Hondebrink E, Steenbergen W, van Leeuwen TG. Laser Doppler perfusion imaging with a high-speed CMOS-camera in: Depeursinge CD, editor. Novel Optical Instrumentation for Biomedical Applications III(ed.). S.l.: s.n.; 2007. Proceedings of SPIE 6631, p. 1-2
Faber DJ, de Bruin M, Aalders MCG, Verbraak FD, van Leeuwen TG. NAOMI: nanoparticle-assisted optical molecular imaging in: Cartwright AN, Nicolau DV, editors. Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV. S.l.: SPIE Conference Proceedings 6647; 2007. 6447, p. 1-10
Faber DJ, van der Meer FJ, van Leeuwen TG. Spectroscopic analysis of arterial wall components using OCT in: Regar E, van Leeuwen TG, Serruys PW, editors. Optical Coherence Tomography in Cardiovascular Research. London: Informa Healthcare; 2007., p. 231-240
Kolkman RGM, Mulder M, Glade CP, van Leeuwen TG, Steenbergen W. Photoacoustic imaging of port-wine stains in: Kolkman RGM, Mulder M, Glade CP, van Leeuwen TG, Steenbergen W, editors. Phototonic Therapeutics and Diagnostics III Kollias; Bernard Choi; Hai Zeng, Reza S. Malek, Brian J. Wong, Justus F. R. Ilgner, K.W. Gregory,Guillermo J. Tearney, H.Hirschberg, Steen J. Madsen (ed). S.l.: s.n.; 2007. 6424, p. 1-2
Kolkman RGM, Mulder M, Glade CP, van Leeuwen TG, Steenbergen W, editors, Phototonic Therapeutics and Diagnostics III Kollias; Bernard Choi; Hai Zeng, Reza S. Malek, Brian J. Wong, Justus F. R. Ilgner, K.W. Gregory,Guillermo J. Tearney, H.Hirschberg, Steen J. Madsen (ed). S.l.: s.n.; 2007. 1p. (SPIE Proceedings; 6424)
Kolkman RG, Steenbergen W, van Leeuwen TG, Reflection mode photoacoustic measurement of speed of sound. OPT EXPRESS 2007;15 (6):3291-3300 [PubMed]
Manohar S, Vaartjes SE, van Hespen JCG, Klaase JM, van den Engh FM, Steenbergen W, van Leeuwen TG, Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics. OPT EXPRESS 2007;15 (19):12277-12285 [PubMed]
Manohar S, Willemink RGH, van der Heijden F, Slump CH, van Leeuwen TG, Concomitant speed-of-sound tomography in photoacoustic imaging. APPL PHYS LETT 2007;91 (13):131911
Rajan V. Speckles in laser Doppler perfusion imaging. Enschede: s.n.; 2007. 153p. ISBN 978-90-365-2580-0 Proefschrift TU Twente, Biofysische Techniek, onderzoek in AMC-UvA. (Promotor(s): van Leeuwen TG; copromotor(s): Steenbergen W)
Rajan V, Varghese B, van Leeuwen TG, Steenbergen W, Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging. OPT EXPRESS 2007;15 (17):10911-10919 [PubMed]
Rajan V, Varghese B, van Leeuwen TG, Steenbergen W, Quantification of spatial intensity correlations and photodetector intensity fluctuations of coherent light reflected from turbid particle suspensions. PHYS REV E 2007;75 (6 Part 1):060901 [PubMed]
Rayavarapu RG, Petersen W, Ungureanu C, Post JN, van Leeuwen TG, Manohar S, Synthesis and bioconjugation of gold nanoparticles as potential molecular probes for light-based imaging techniques. INT J BIOMED IMAGING 2007;2007:29817 [PubMed]
Regar E, van Leeuwen TG, Serruys PW, editors, Optical Coherence Tomography in Cardiovascular Research. London: Informa Healthcare; 2007. 338p. ISBN 1 84184 611 2
van der Meer FJ, van Leeuwen TG. Resolution versus imaging depth: every advantage has it advantage in: Regar E, van Leeuwen TG, Serruys PW, editors. Optical Coherence Tomography in Cardiovascular Research. London: Informa Healthcare; 2007., p. 115-120
van Leeuwen TG, Regar E, Serruys PW. Summary and outlook in: Regar E, van Leeuwen TG, Serruys PW, editors. Optical Coherence Tomography in Cardiovascular Research. London: Informa Healthcare; 2007., p. 329-331
van Velthoven MEJ, Faber DJ, Verbraak FD, van Leeuwen TG, de Smet MD, Recent developments in optical coherence tomography for imaging the retina. PROG RETIN EYE RES 2007;26 (1):57-77 [PubMed]
Varghese B. Path length resolved optical doppler perfusion monitoring. Enschede: s.n.; 2007. 140p. ISBN 978-90-365-2581-7 Proefschrift Universiteit Twente, Biofysische Techniek. (Promotor(s): van Leeuwen AGJM; copromotor(s): Steenbergen W)
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, editors, Biomedical Applications of Light Scattering, Adam Wax; Vadim Backmann (ed.). S.l.: s.n.; 2007. 1p. (SPIE Proceedings; 6446)
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, Discrimination between Doppler-shifted and non-shifted light in coherence domain path length resolved measurements of multiply scattered light. OPT EXPRESS 2007;15 (20):13340-13350 [PubMed]
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, Evaluation of a multimode fiber optic low coherence interferometer for path length resolved Doppler measurements of diffuse light. REV SCI INSTRUM 2007;78 (12):126103 [PubMed]
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, Path-length-resolved measurements of multiple scattered photons in static and dynamic turbid media using phase-modulated low-coherence interferometry. J BIOMED OPT 2007;12 (2):024020 [PubMed]
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, Path-length-resolved optical Doppler perfusion monitoring. J BIOMED OPT 2007;12 (6):060508 [PubMed]
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W. Quantification of Doppler broadening in path lenght resolved diffusive light scattering using phase modulated low coherence interferometry. in: Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, editors. Biomedical Applications of Light Scattering, Adam Wax; Vadim Backmann (ed.). S.l.: s.n.; 2007. 6446, p. 1-2
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W, Quantification of optical Doppler broadening and optical path lengths of multiply scattered light by phase modulated low coherence interferometry. OPT EXPRESS 2007;15 (15):9157-9165 [PubMed]
Beek JF, Aalders MC, Verbraak FD, van Leeuwen TG, Book review: lasers and current optical techniques in biology, edited bu G. Palumbo and R.Pratesi. LASER MED SCI 2006;21:101-102
Faber DJ, van Velthoven MEJ, de Bruin M, Aalders MCG, Verbraak FD, Graf C, van Leeuwen TG. NAOMI: nanoparticle assisted optical molecular imaging in: Izatt JA, Fujimoto JG, Tuchin VV, editors. Coherence domain optical coherence tomography in biomedicine X. Proc. SPIE 6079 607905-1. S.l.: s.n.; 2006.
Kolkman RGM, Bosschaart N, Kok B, van Leeuwen TG, Steenbergen W, Photoacoustic imaging of valves in superficial veins. LASER SURG MED 2006;38 (8):740-744 [PubMed]
Kolkman RGM, Steenbergen W, van Leeuwen TG, In vivo photoacoustic imaging of blood vessels with a pulsed laser diode. LASER MED SCI 2006;21 (3):134-139 [PubMed]
Mik EG, Stap J, Sinaasappel M, Beek JF, Aten JA, van Leeuwen TG, Ince C, Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX. NAT METHODS 2006;3 (11):939-945 [PubMed]
Rajan V, Varghese B, van Leeuwen TG, Steenbergen W, Speckles in laser Doppler perfusion imaging. OPT LETT 2006;31 (4):468-470 [PubMed]
van der Meer FJ, Faber DJ, Cilesiz I, van Gemert MJC, van Leeuwen TG, Temperature-dependent optical properties of individual vascular wall components measured by optical coherence tomography. J BIOMED OPT 2006;11 (4):041120 [PubMed]
van der Meer FJ, van Leeuwen TG. Resolution versus imaging depth: every advantage has its disadvantage in: Regar E, van Leeuwen TG, Serruys PW, editors. Optical coherence tomography in cardiovascular research. S.l.: CRC; 2007., p. 115-120
van Leeuwen TG, Regar E, Serruys PW. Summary and outlook in: Regar E, van Leeuwen TG, Serruys PW, editors. Optical coherence tomography in cardiovascular research. S.l.: CRC; 2007., p. 329-332
van Leeuwen TG, van der Meer FJ, Faber DJ, Cilesiz I. Temperature dependent optical properties of individual vascular wall components measured by OCT in: Kollias N, Zeng H, Choi B, Malek RS, Wong BJF, Ilgner JFR, Trowers EA, de Riese WTW, Hirschberg H, Madsen SJ, Lucroy MD, Tate LP, Gregory KW, Tearney GJ, editors. Photonic therapeutics and diagnostics II. Proc. SPIE Vol. 6078 60782A-1. S.l.: s.n.; 2006.
Varghese B, Rajan V, van Leeuwen TG, Steenbergen W. Path length resolved Doppler measurements of multiple scattered photons in turbid media for various absorptions using phase modulated low-coherence interferometry in: Grzymala R, Haeberle O, editors. Biophotonics and new therapy frontiers. Proc. SPIE Vol. 6191 619119-1. S.l.: s.n.; 2006.
Cense B. Optical coherence tomography for retinal imaging. S.l.: s.n.; 2005. -p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen TG; copromotor(s): )
Faber DJ. Functional optical coherence tomography. Spatially resolved measurements of optical properties. S.l.: s.n.; 2005. 102p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM, van Gemert MJC; copromotor(s): )
Faber DJ, Mik EG, Aalders MCG, van Leeuwen TG, Toward assessment of blood oxygen saturation by spectroscopic optical coherence tomography. OPT LETT 2005;30 (9):1015-1017 [PubMed]
Kharin A. Titel onbekend ?. S.l.: s.n.; 2005. -p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen TG; copromotor(s): )
Manohar S, Kharine A, van Hespen JCG, Steenbergen W, van Leeuwen TG, The Twente Photoacoustic Mammoscope: system overview and performance. PHYS MED BIOL 2005;50 (11):2543-2557 [PubMed]
Siphanto RI, Thumma KK, Kolkman RGM, van Leeuwen TG, de Mul FFM, van Neck JW, van Adrichem LNA, Steenbergen W, Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis. OPT EXPRESS 2005;13 (1):89-95 [PubMed]
van der Meer FJ. Vascular applications of quantitative optical coherence tomography. S.l.: s.n.; 2005. 135p. ISBN 978090196688 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Leeuwen AGJM; copromotor(s): )
van der Meer FJ, Faber DJ, Baraznji Sassoon DM, Aalders MC, Pasterkamp G, van Leeuwen TG, Localized measurement of optical attenuation coefficients of atherosclerotic plaque constituents by quantitative optical coherence tomography. IEEE T MED IMAGING 2005;24 (10):1369-1376 [PubMed]
van der Meer FJ, Faber DJ, Perrée J, Pasterkamp G, Baraznji Sassoon D, van Leeuwen TG, Quantitative optical coherence tomography of arterial wall components. LASER MED SCI 2005;20 (1):45-51 [PubMed]
Verbraak FD, de Bruin DM, Sulak M, de Jong LAMS, Aalders M, Faber DJ, van Leeuwen TG, Optical coherence tomography of the Ex-PRESS miniature glaucoma implant. LASER MED SCI 2005;20 (1):41-44 [PubMed]
Faber DJ, Aalders MCG, Mik EG, Hooper BA, van Gemert MJC, van Leeuwen TG, Oxygen saturation-dependent absorption and scattering of blood. PHYS REV LETT 2004;93 (2):028102 [PubMed]
Faber D, van der Meer F, Aalders M, van Leeuwen T, Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography. OPT EXPRESS 2004;12 (19):4353-4365 [PubMed]
Kolkman RGM, Hondebrink E, Steenbergen W, van Leeuwen TG, de Mul FFM, Photoacoustic imaging of blood vessels with a double-ring sensor featuring a narrow angular aperture. J BIOMED OPT 2004;9 (6):1327-1335 [PubMed]
Kolkman RGM, Klaessens JHGM, Hondebrink E, Hopman JCW, de Mul FFM, Steenbergen W, Thijssen JM, van Leeuwen TG, Photoacoustic determination of blood vessel diameter. PHYS MED BIOL 2004;49 (20):4745-4756 [PubMed]
Manohar S, Kharine A, van Hespen JCG, Steenbergen W, van Leeuwen TG, Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms. J BIOMED OPT 2004;9 (6):1172-1181 [PubMed]
Mik EG, van Leeuwen TG, Raat NJ, Ince C, Quantitative determination of localized tissue oxygen concentration in vivo by two-photon excitation phosphorescence lifetime measurements. J APPL PHYSIOL 2004;97 (5):1962-1969 [PubMed]
Faber DJ, Mik EG, Aalders MCG, van Leeuwen TG, Light absorption of (oxy-)hemoglobin assessed by spectroscopic optical coherence tomography. OPT LETT 2003;28 (16):1436-1438 [PubMed]
Perrée J, van Leeuwen TG, Kerindongo R, Spaan JAE, VanBavel E, Function and structure of pressurized and perfused porcine carotid arteries - Effects of in vitro balloon angioplasty. AM J PATHOL 2003;163 (5):1743-1750 [PubMed]
van Leeuwen TG, Faber DJ, Aalders MC, Measurement of the axial point spread function in scattering media using single-mode fiber-based optical coherence tomography. IEEE J SEL TOP QUANT 2003;9 (2):227-233
Beek JF, Aalders MCG, van Leeuwen TG, van Gemert MJC, Notes on past and current research at the Laser Centre in Amsterdam. MED LASER APPL 2002;17:65-72
Cilesiz I, Fockens P, Kerindongo R, Faber D, Tytgat G, ten Kate F, van Leeuwen T, Comparative optical coherence tomography imaging of human esophagus: How accurate is localization of the muscularis mucosae?. GASTROINTEST ENDOSC 2002;56 (6):852-857 [PubMed]
Perrée J, van Leeuwen TG, Velema E, Smeets M, de Kleijn D, Borst C, UVB-activated psoralen reduces luminal narrowing after balloon dilation because of inhibition of constrictive remodeling. PHOTOCHEM PHOTOBIOL 2002;75 (1):68-75 [PubMed]
Petoukhova AL, Steenbergen W, van Leeuwen TG, de Mul FFM, Effects of absorption on coherence domain path length resolved dynamic light scattering in the diffuse regime. APPL PHYS LETT 2002;81 (4):595-597
van Leeuwen TG, Kulkarni MD, Yazdanfar S, Rollins AM, Izatt JA, High-flow-velocity and shear-rate imaging by use of color Doppler optical coherence tomography. OPT LETT 1999;24 (22):1584-1586 [PubMed]
Konings MK, van Leeuwen TG, Mali WP, Viergever MA, Torsion measurement of catheters using polarized light in a single glass fibre. PHYS MED BIOL 1998;43 (5):1049-1057 [PubMed]
Kulkarni MD, van Leeuwen TG, Yazdanfar S, Izatt JA, Velocity-estimation accuracy and frame-rate limitations in color Doppler optical coherence tomography. OPT LETT 1998;23 (13):1057-1059 [PubMed]
Perrée J, van Leeuwen TG, Velema E, Borst C, Psoralen and long wavelength ultraviolet radiation as an adjuvant therapy for prevention of intimal hyperplasia and constrictive remodeling after balloon dilation: a study in the rabbit iliac artery. LASER SURG MED 1998;23 (5):281-290 [PubMed]
van Leeuwen TG, Velema E, Pasterkamp G, Post MJ, Borst C, Saline flush during excimer laser angioplasty: short and long term effects in the rabbit femoral artery. LASER SURG MED 1998;23 (3):128-140 [PubMed]
Clarijs JA, Pasterkamp G, Schoneveld AH, van Leeuwen TG, Hillen B, Borst C, Compensatory enlargement in coronary and femoral arteries is related to neither the extent of plaque-free vessel wall nor lesion eccentricity. A postmortem study. ARTERIOSCL THROM VAS 1997;17 (11):2617-2621 [PubMed]
Eefting FD, Pasterkamp G, Clarijs RJ, van Leeuwen TG, Borst C, Remodeling of the atherosclerotic arterial wall: a determinant of luminal narrowing in human coronary arteries. CORONARY ARTERY DIS 1997;8 (7):415-421 [PubMed]
Pasterkamp G, Peters RJ, Kok WE, van Leeuwen TG, Borst C, Arterial remodeling after balloon angioplasty of the coronary artery: an intravascular ultrasound study. PICTURE Investigators. PostTreatment IntraCoronary Transluminal Ultrasound Result Evaluation. AM HEART J 1997;134 (4):680-684 [PubMed]
van Leeuwen TG, Borst C, Fundamental laser-tissue interactions. SEMIN INTERV CARDIOL 1996;1 (2):121-128 [PubMed]
van Leeuwen TG, Jansen ED, Welch AJ, Borst C, Excimer laser induced bubble: dimensions, theory, and implications for laser angioplasty. LASER SURG MED 1996;18 (4):381-390 [PubMed]
Jansen ED, van Leeuwen TG, Motamedi M, Borst C, Welch AJ, PARTIAL VAPORIZATION MODEL FOR PULSED MIDINFRARED LASER-ABLATION OF WATER. J APPL PHYS 1995;78 (1):564-571
Jansen ED, van Leeuwen TG, Motamedi M, Borst C, Welch AJ, Temperature dependence of the absorption coefficient of water for midinfrared laser radiation. LASER SURG MED 1994;14 (3):258-268 [PubMed]
van Leeuwen TG, Jansen ED, Motamedi M, Welch AJ, Borst C, EXCIMER-LASER ABLATION OF SOFT-TISSUE - A STUDY OF THE CONTENT OF RAPIDLY EXPANDING AND COLLAPSING BUBBLES. IEEE J QUANTUM ELECT 1994;30 (5):1339-1347
Borst C, van Leeuwen TG, Post MJ, In search of the optimized excimer laser angioplasty system. CIRCULATION 1993;88 (1):334-335 [PubMed]
van Leeuwen TG, Meertens JH, Velema E, Post MJ, Borst C, Intraluminal vapor bubble induced by excimer laser pulse causes microsecond arterial dilation and invagination leading to extensive wall damage in the rabbit. CIRCULATION 1993;87 (4):1258-1263 [PubMed]
van Erven L, van Leeuwen TG, Post MJ, van der Veen MJ, Velema E, Borst C, Mid-infrared pulsed laser ablation of the arterial wall. Mechanical origin of "acoustic" wall damage and its effect on wall healing. J THORAC CARDIOV SUR 1992;104 (4):1053-1059 [PubMed]
van Leeuwen TG, van Erven L, Meertens JH, Motamedi M, Post MJ, Borst C, Origin of arterial wall dissections induced by pulsed excimer and mid-infrared laser ablation in the pig. J AM COLL CARDIOL 1992;19 (7):1610-1618 [PubMed]
van Leeuwen TG, van der Veen MJ, Verdaasdonk RM, Borst C, Noncontact tissue ablation by holmium:YSGG laser pulses in blood. LASER SURG MED 1991;11 (1):26-34 [PubMed]
Key publications

Ungureanu C, Kroes R, Petersen W, Groothuis TAM, Ungureanu F, Janssen H, van Leeuwen FWB, Kooyman RPH, Manohar S, van Leeuwen TG, Light interactions with gold nanorods and cells: implications for photothermal nanotherapeutics. NANO LETT 2011;11 (5):1887-1894 [PubMed]
van der Pol E, van Gemert MJC, Sturk A, Nieuwland R, van Leeuwen TG, Single vs. swarm detection of microparticles and exosomes by flow cytometry. J THROMB HAEMOST 2012;10 (5):919-930 [PubMed]
van der Pol E, Coumans FAW, Sturk A, Nieuwland R, van Leeuwen TG, Refractive Index Determination of Nanoparticles in Suspension Using Nanoparticle Tracking Analysis. NANO LETT 2014;14 (11):6195-6201 [PubMed]
van Dam A, Schwarz JCV, de Vos J, Siebes M, Sijen T, van Leeuwen TG, Aalders MCG, Lambrechts SAG, Oxidation monitoring by fluorescence spectroscopy reveals the age of fingermarks. ANGEW CHEM INT EDIT 2014;53 (24):6272-6275 [PubMed]
Faber D, van der Meer F, Aalders M, van Leeuwen T, Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography. OPT EXPRESS 2004;12 (19):4353-4365 [PubMed]


All Publications

Curriculum Vitae

Ton van Leeuwen (born in 1963 in Amsterdam) graduated cum laude in Experimental Physics of the University of Amsterdam in 1989. His Master of Science research was performed at the Department of Atomic Physics (Zeeman laboratory, laser spectroscopy). He completed his PhD research in the Experimental Cardiology Laboratory in the Utrecht Medical Centre in 1993 on the use of pulsed lasers for angioplasty of coronary arteries by defending (cum laude) his thesis entitled "Bubble formation during pulsed mid-infrared and excimer laser ablation: Origin and implications for laser angioplasty" (promotors: Prof. dr. C. Borst, Lab. for Experimental Cardiology, University of Utrecht and Prof. dr. ir. M.J.C. van Gemert, AMC Laser Center, University of Amsterdam).
Thereafter he was involved in various research projects at the Interuniversity Cardiology Institute of the Netherlands (ICIN) of the KNAW: He was principal investigator of the Netherlands Heart Foundation (NHS) project "Local inhibition of Cell Proliferation in the Arterial Wall by Psoralen and Local Photodynamic Therapy: a Possible Strategy to Prevent Restenosis" and ad interim project leader of ICIN project 18 "The Arterial Wall".

 

In 1997 and 1998, supported by a grant from the ICIN, he investigated the potential cardiovascular use of optical coherence tomography (OCT) at Case Western Reverse University and Cleveland University Hospitals in Cleveland, USA.

 

Ton was appointed as a staff member of the AMC Laser Centre in 1998 at which he continued his research on OCT. He was the principal investigator of various projects: NWO–Platform Alternatives for Animal Experiments ("Perfused Porcine Coronary Arteries as a Testing Laboratory of the Intervention Cardiology"), NHS projects ("Reduction of arterial shrinkage by UVB and PUVB therapy during balloon angioplasty: effect on collagen and elastin organization, formation and degradation" and "Optical Coherence Tomography (OCT) Imaging in Cardiology: Application of a Novel, High Resolution, Optical Imaging Technique to Visualize Unstable Plaque and Blood Flow Shear Rate Distribution); NWO Equipment grant ("Optical Coherence Tomography: high resolution non-invasive diagnostic imaging in medicine"); FOM-projects "Optical Coherence Tomography: Novel High Resolution Non-Invasive Diagnostic Imaging In Medicine" and ICIN project 32 ("Intravascular diagnosis of atherosclerosis and restenosis by means of IntraVascular UltraSound, Optical Coherence Tomography and Raman spectroscopy") and EU 5th Call project MEDPHOT ("Optical Methods for Medical Diagnosis and Monitoring of Diseases"); Senter BTS project OCTIC ("Optical Coherence Tomography Imaging in Cardiology")

 

He was appointed as Professor in the Clinical Application of Biomedical Optics at the University of Twente in 2001 (part time, 0.2). From 2003 - 2008, he headed the Biomedical Optics Group at the Science faculty and the Biomedical Technology Institute at the UT (0.5 appointment). At the UT, he started and headed the spearhead project NIMTIK ("Non-Invasive Molecular Tumor Imaging and Killing") and was co-PI of STW projects ("Fast and depth sensitive laser Doppler imaging of tissue perfusion" and "Towards non-invasive acousto-optic, quantitative monitoring of chemical species in human blood or tissue") and IOP - Photonic Devices projects ("PRESSMIT Plasmonic nanoparticle based molecular imaging and therapy of cancers: in vitro to preclinical studies" and "HYMPACT Hybrid Mammography using Photacoustic Computed Tomography"). He developed three courses: “Medical Technology” for Biomedical Technology and TBK bachelor students, “Non-invasive Diagnostics” for Biomedical Engineering master students, and  “Microscopic Imaging Techniques” for Technical Medicine master students.

 

He was appointed as Professor in Biomedical Photonics (in 2007) and head of the Biomedical Engineering and Physics department (in 2008) in the Faculty of Medicine at the Academic Medical Centre of the University of Amsterdam (AMC-UvA). He developed the courses "Introduction to Biomedical Physics" and the worshop "Blood" for BSc Physics students. In  2009, he was appointed as full professor in Biomedical Physics (AMC-UvA).  Projects were started, e.g. IOP Photonic Devices ("IR SWEPT: IR swept source for high resolution functional imaging in medicine") and Smartmix MEMPHIS ("Merging Electronics and Micro & nano-PHotonics in Integrated Systems"). Current projects within his group include IOP Photonic Devices project "low-cost handheld optical coherence tomography device", ZON-MW project "Sense, zoom and specify" (within institute Quantivision), STW project "Sensor for body hydration monitoring" (within the research program Sport) , STW projects "OBAMA: optical bladder anatomy mapping and functional analysis" and "PROSPECT: spectroscopic biopsy of the prostate" which are part of the STW Perspective program iMIT. New projects on the development of novel detection methods for microvessel characterisation started recently (within STW perspectief programs MEMPHIS and CANCER-ID).

 

He initiated the Center of Research Excellence within the Innovative Medical Devices Initiative of the Netherlands Science Organization, resulting in the Institute Quantivison, of which he currently is the technical scientific leader. He is coordinator for the Physics of Life and Health master track within the Amsterdam Master of Physics.

 

Research programmes

Biomedical photonics for functional and molecular imaging

The research programme is structured along the following research lines:

  • Hyperspectral imaging (Prof dr ing Aalders): based on his VIDI project (Depth-resolved Optical Spectroscopic Imaging (DOSI) in tissue), non invasive measurement of bilirubin (in cooperation with the Neonatology department) and the age of bruises (in order to better detect child abuse) have been demonstrated. Forensic applications of hyperspectral imaging is utilised for the detection and age determination of blood stains (together with e.g. the Netherlands Forensic Institute and Forensic Technological Solutions BV) and on finger print analysis (Dr A van Dam). 
  • Functional imaging (Dr Ir Dirk Faber and dr DM de Bruin), with clinical spin-off towards Urology, Pulmonology, Oncology and Ophthalmology: based on anaysis of the optical signals, differences in the optical properties (absorption and scattering) of the tissue are related to the presencense of superficial tumors. Based on speckle analysis, blood flow is characterised.
  • The integration and combination of different imaging technologies for molecular and functional imaging will be explored e.g to guide biopsys (in cooperation with gastro-enterology and urology), to characteris micro-vesicles (Dr FAW Coumans and dr E van der Pol) in biological fluids (blood, urine, etc, together with experimental biochemistry, Dr R Nieuwland and Prof A Sturk) and to initiate new developments by starting research projects for minimally invasie optical catheters and using integrated optics  for small and dedicated monitoring and imaging devices in the clinic. 

 

Faculty
Prof. dr. A.G.J.M. van Leeuwen MSc PhD
Prof. dr. ing. M.C.G. Aalders
Dr. ir. D.J. Faber

Postdocs
Dr. I.B.I. Avci MSc
Dr. D.M. de Bruin MSc PhD
Dr. ir. F.A.W. Coumans
Dr. A. van Dam
Dr. ir. E. van der Pol (Exometry B.V.)
Dr. A. Riordan

PhD Students
N. Achetib
Drs. M. Almasian
Drs. M.T.J. Bus
J.E. Freund
Ir. E. Gool MSc
Drs. R.J.M. Hoveling
I. Jansen
Drs. S.M. Jansen
Drs. M.P. Jelvehgaran
M. Lucas
Drs. B.G. Muller
Ir. L.M. Peinado Cortes
Drs. A.L. Post
L. de Rond
Drs. A. Swaan
L.S. Wilk MSc
X. Zhang
Drs. M. Stehouwer

Others
Ing. P.R. Bloemen
Prof. dr. ir. M.J.C. van Gemert

Other research related activities
  • Membership of editorial board / Editorship, JOURNAL OF BIOMEDICAL OPTICS
  • Membership of editorial board / Editorship, LASERS IN MEDICAL SCIENCE
  • Membership of advisory board / Consultant, Other
  • Board of directors / Trustees / Supervisory board, UvA “Co van Ledden Hulsebosch Center for Forensic Sciences and Medicine”
  • Membership of advisory board / Consultant, Innovative Medical Devices Initiative IMDI.nl
  • Membership of medical or scientific committee, University of Amsterdam, Universitaire Onderzoek Commissie (UOC)
  • Membership of medical or scientific committee, NWO: Netherlands Organisation, FOM: advisory and monitoring committee on “Phenomenological physics”
Current research funding
  • AMC
  • Europese Unie
  • NWO Vrijgesteld
  • Rijksdienst voor Ondernemend Nederland
  • SURFnet bv
  • Technologiestichting STW
  • ZonMw