Alle publicaties van M. Heger PhD

2017

  • Best MG, Sol N, In 't Veld SGJG, Vancura A, Muller M, Niemeijer ALN, Fejes AV, Tjon Kon Fat LA, Huis In 't Veld AE, Leurs C, Le Large TY, Meijer LL, Kooi IE, Rustenburg F, Schellen P, Verschueren H, Post E, Wedekind LE, Bracht J, Esenkbrink M, Wils L, Favaro F, Schoonhoven JD, Tannous J, Meijers-Heijboer H, Kazemier G, Giovannetti E, Reijneveld JC, Idema S, Killestein J, Heger M, de Jager SC, Urbanus RT, Hoefer IE, Pasterkamp G, Mannhalter C, Gomez-Arroyo J, Bogaard HJ, Noske DP, Vandertop WP, van den Broek D, Ylstra B, Nilsson RJA, Wesseling P, Karachaliou N, Rosell R, Lee-Lewandrowski E, Lewandrowski KB, Tannous BA, de Langen AJ, Smit EF, van den Heuvel MM, Wurdinger T, Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets. CANCER CELL 2017;32 (2):238-252.e9 [PubMed]
  • Broekgaarden M, Weijer R, van Wijk AC, Cox RC, Egmond MR, Hoebe R, van Gulik TM, Heger M, Photodynamic Therapy with Liposomal Zinc Phthalocyanine and Tirapazamine Increases Tumor Cell Death via DNA Damage. J BIOMED NANOTECHNOL 2017;13 (2):204-220
  • Coelen RJS, de Keijzer MJ, Weijer R, Loukachov VV, Wiggers JK, Mul FPJ, van Wijk ACWA, Fong Y, Heger M, van Gulik TM, In vitro detection of cholangiocarcinoma cells using a fluorescent protein-expressing oncolytic herpes virus. CANCER GENE THER 2017;24 (5):227-232 [PubMed]
  • Coelen RJS, Vogel JA, Vroomen LGPH, Roos E, Busch ORC, van Delden OM, van Delft F, Heger M, van Hooft JE, Kazemier G, Klümpen HJ, van Lienden KP, Rauws EAJ, Scheffer HJ, Verheul HM, de Vries J, Wilmink JW, Zonderhuis BM, Besselink MG, van Gulik TM, Meijerink MR, Ablation with irreversible electroporation in patients with advanced perihilar cholangiocarcinoma (ALPACA): a multicentre phase I/II feasibility study protocol. BMJ OPEN 2017;7 (9):e015810 [PubMed]
  • Ergin B, Heger M, Kandil A, Demirci-Tansel C, Ince C, Mycophenolate mofetil improves renal haemodynamics, microvascular oxygenation, and inflammation in a rat model of supra-renal aortic clamping-mediated renal ischaemia reperfusion injury. CLIN EXP PHARMACOL P 2017;44 (2):294-304 [PubMed]
  • Olthof PB. Enhancement of liver regeneration and liver surgery. S.l.: s.n.; 2017. 390p. ISBN 978-94-6233-531-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM; copromotor(s): Heger M, Bennink RJ)
  • Olthof PB, Coelen RJ, Heger M, Klümpen HJ, Rauws EA, van Gulik TM, Emerging local ablative therapies for unresectable perihilar cholangiocarinoma: Time for re-appraisal. UNITED EUR GASTROENT 2017;5 (3):455-457 [PubMed]
  • Olthof PB, Coelen RJS, Bennink RJ, Heger M, Lam MF, Besselink MG, Busch OR, van Lienden KP, van Gulik TM, Tc-99m-mebrofenin hepatobiliary scintigraphy predicts liver failure following major liver resection for perihilar cholangiocarcinoma. HPB 2017;19 (10):850-858 [PubMed]
  • Olthof PB, Heger M, van Lienden KP, de Bruin K, Bennink RJ, van Gulik TM, Comparable liver function and volume increase after portal vein embolization in rabbits and humans. SURGERY 2017;161 (3):658-665 [PubMed]
  • Olthof PB, Huisman F, Schaap FG, van Lienden KP, Bennink RJ, van Golen RF, Heger M, Verheij J, Jansen PL, Olde Damink SW, van Gulik TM, Effect of obeticholic acid on liver regeneration following portal vein embolization in an experimental model. BRIT J SURG 2017;104 (5):590-599 [PubMed]
  • Olthof PB, Schadde E, van Lienden KP, Heger M, de Bruin K, Verheij J, Bennink RJ, van Gulik TM, Hepatic parenchymal transection increases liver volume but not function after portal vein embolization in rabbits. SURGERY 2017;162 (4):732-741 [PubMed]
  • Olthof PB, van Golen RF, Meijer B, van Beek AA, Bennink RJ, Verheij J, van Gulik TM, Heger M, Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury. BBA-MOL BASIS DIS 2017;1863 (2):375-385 [PubMed]
  • Reiniers MJ. Visualizing and targeting oxidative stress in hepatic ischemia-reperfusion injury. S.l.: s.n.; 2017. 281p. ISBN 9789462336582 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM; copromotor(s): Heger M)
  • Reiniers MJ, Olthof PB, van Golen RF, Heger M, van Beek AA, Meijer B, Leen R, van Kuilenburg ABP, Mearadji B, Bennink RJ, Verheij J, van Gulik TM, Hypothermic perfusion with retrograde outflow during right hepatectomy is safe and feasible. SURGERY 2017;162 (1):48-58 [PubMed]
  • Reiniers MJ, van Golen RF, Bonnet S, Broekgaarden M, van Gulik TM, Egmond MR, Heger M, Preparation and Practical Applications of 2 ',7 '-Dichlorodihydrofluorescein in Redox Assays. ANAL CHEM 2017;89 (7):3853-3857 [PubMed]
  • van Golen RF. A treatment rationale for surgery-induced liver injury. S.l.: s.n.; 2017. 468p. ISBN 9789402806540 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM; copromotor(s): Heger M)
  • Weijer R. Enhancing photodynamic therapy of refractory solid cancers. S.l.: s.n.; 2017. 215p. ISBN 978-94-6233-534-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM; copromotor(s): Heger M)
  • Weijer R, Clavier S, Zaal EA, Pijls MME, van Kooten RT, Vermaas K, Leen R, Jongejan A, Moerland PD, van Kampen AHC, van Kuilenburg ABP, Berkers CR, Lemeer S, Heger M, Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy. CELL MOL LIFE SCI 2017;74 (6):1133-1151 [PubMed]
  • Wenwei C, Yirong Y, Stevens KM, Heger M, Peng X, Application of modified small bladder patch-to-bladder double-layer sutures to improve renal transplantation in mice. EUR SURG 2017;49 (1):17-22 [PubMed]
  • Wiggers JK, van Golen RF, Verheij J, Dekker AM, van Gulik TM, Heger M, Atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers. BMC SURG 2017;17 (1):35 [PubMed]
  • Zhang H, Gao P, Xiao X, Heger M, Geng L, Fan B, Yuan Y, Huang C, Chen G, Liu Y, Hu Y, Yu X, Wu S, Wang L, Wang Z, A liquid biopsy-based method for the detection and quantification of circulating tumor cells in surgical osteosarcoma patients. INT J ONCOL 2017;50 (4):1075-1086 [PubMed]

2016

  • Broekgaarden M. New strategies to enhance photodynamic therapy for solid tumors. S.l.: s.n.; 2016. 254p. ISBN 978-94-6203-974-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM; copromotor(s): Heger M)
  • Broekgaarden M, van Vught R, Oliveira S, Roovers RC, van Bergen En Henegouwen PMP, Pieters RJ, van Gulik TM, Breukink E, Heger M, Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy. NANOSCALE 2016;8 (12):6490-6494 [PubMed]
  • Broekgaarden M, Weijer R, Krekorian M, van den IJssel B, Kos M, Alles LK, van Wijk AC, Bikadi Z, Hazai E, van Gulik TM, Heger M, Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes. NANO RES 2016;9 (6):1639-1662
  • Bruinsma BG, Sridharan GV, Weeder PD, Avruch JH, Saeidi N, Özer S, Geerts S, Porte RJ, Heger M, van Gulik TM, Martins PN, Markmann JF, Yeh H, Uygun K, Metabolic profiling during ex vivo machine perfusion of the human liver. SCI REP-UK 2016;6:22415 [PubMed]
  • Coelen RJS. Risk assessment and perioperative care in perihilar cholangiocarcinoma. S.l.: s.n.; 2016. 301p. ISBN 9789462334854 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM; copromotor(s): Rauws EAJ, Heger M)
  • de Bruin DM, Broekgaarden M, van Gemert MJC, Heger M, de la Rosette JJ, van Leeuwen TG, Faber DJ, Assesment of apoptosis induced changes in scattering using optical coherence tomography. J BIOPHOTONICS 2016;9 (9):913-923 [PubMed]
  • Hopkins SL, Siewert B, Askes SHC, Veldhuizen P, Zwier R, Heger M, Bonnet S, An in vitro cell irradiation protocol for testing photopharmaceuticals and the effect of blue, green, and red light on human cancer cell lines. PHOTOCH PHOTOBIO SCI 2016;15 (5):644-653 [PubMed]
  • Lionarons DA, Heger M, van Golen RF, Alles LK, van der Mark VA, Kloek JJ, de Waart DR, Marsman HA, Rusch H, Verheij J, Beuers U, Paulusma CC, van Gulik TM, Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport. SCI REP-UK 2016;6:31829 [PubMed]
  • Liu Y, Rodrigues JPGLM, Bonvin AMJJ, Zaal EA, Berkers CR, Heger M, Gawarecka K, Swiezewska E, Breukink E, Egmond MR, New Insight into the Catalytic Mechanism of Bacterial MraY from Enzyme Kinetics and Docking Studies. J BIOL CHEM 2016;291 (29):15057-15068 [PubMed]
  • Olthof PB, Huiskens J, Schulte NR, Wicherts DA, Besselink MG, Busch OR, Heger M, van Gulik TM, Postoperative peak transaminases correlate with morbidity and mortality after liver resection. HPB 2016;18 (11):915-921 [PubMed]
  • Olthof PB, Huisman F, van Golen RF, Cieslak KP, van Lienden KP, Plug T, Meijers JCM, Heger M, Verheij J, van Gulik TM, Use of an absorbable embolization material for reversible portal vein embolization in an experimental model. BRIT J SURG 2016;103 (10):1306-1315 [PubMed]
  • Olthof PB, Reiniers MJ, Dirkes MC, van Gulik TM, Heger M, van Golen RF, Protective Mechanisms of Hypothermia in Liver Surgery and Transplantation. MOL MED 2016;22:833-846
  • van Raath MI, Weijer R, Nguyen GH, Choi B, de Kroon AI, Heger M, Tranexamic Acid-Encapsulating Thermosensitive Liposomes for Site-Specific Pharmaco-Laser Therapy of Port Wine Stains. J BIOMED NANOTECHNOL 2016;12 (8):1617-1640 [PubMed]
  • van Riel WG, van Golen RF, Reiniers MJ, Heger M, van Gulik TM, How much ischemia can the liver tolerate during resection?. HEPATOL SURG NUTR 2016;5 (1 2):58-71 [PubMed]
  • Weijer R, Broekgaarden M, Krekorian M, Alles LK, van Wijk AC, Mackaaij C, Verheij J, van der Wal AC, van Gulik TM, Storm G, Heger M, Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy. ONCOTARGET 2016;7 (3):3341-3356 [PubMed]

2015

  • Broekgaarden M, Kos M, Jurg FA, van Beek AA, van Gulik TM, Heger M, Inhibition of NF-κB in Tumor Cells Exacerbates Immune Cell Activation Following Photodynamic Therapy. INT J MOL SCI 2015;16 (8):19960-19977 [PubMed]
  • Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M, Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. CANCER METAST REV 2015;34 (4):643-690 [PubMed]
  • Dirkes MC, Milstein DMJ, Heger M, van Gulik TM, Absence of Hydrogen Sulfide-Induced Hypometabolism in Pigs: A Mechanistic Explanation in Relation to Small Nonhibernating Mammals. EUR SURG RES 2015;54 (3-4):178-191 [PubMed]
  • Dirkes MC, van Gulik TM, Heger M, Survey and critical appraisal of pharmacological agents with potential thermo-modulatory properties in the context of artificially induced hypometabolism. J CLIN TRANSL RES 2015;1 (1):6-21
  • Dirkes MC, van Gulik TM, Heger M, The physiology of artifical hibernation. J CLIN TRANSL RES 2015;2:78-93
  • Heger M, Editor's inaugural issue foreword: perspectives on translational and clinical research. J CLIN TRANSL RES 2015;1:1-5
  • Heger M, Reiniers MJ, van Golen RF, Mitochondrial metabolomics unravel the primordial trigger of ischemia/reperfusion injury. GASTROENTEROLOGY 2015;148 (5):1071-1073 [PubMed]
  • Heger M, van der Wal AC, Storm G, van Gemert MJ, Potential therapeutic benefits stemming from the thermal nature of irreversible electroporation of solid cancers. HEPATOB PANCREAT DIS 2015;14 (3):331-333 [PubMed]
  • Liu Y, Qin R, Zaat SAJ, Breukink E, Heger M, Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections. J CLIN TRANSL RES 2015;1 (3):140-167
  • Olthof PB, Reiniers MJ, Dirkes MC, van Gulik TM, Heger M, van Golen RF, Protective mechanisms of hypothermia in liver surgery and transplantation. MOL MED 2015;21:833-846 [PubMed]
  • Olthof PB, van Golen RF, Reiniers MJ, Kos M, Alles LK, Maas MAW, Verheij J, van Gulik TM, Heger M, IL-23 and IL-17 are not involved in hepatic ischemia reperfusion injury in mouse and man. J CLIN TRANSL RES 2015;1 (3):180-189
  • Pabittei DR, de Boon WMI, Heger M, van Golen RF, Balm R, Legemate DA, de Mol BAJM, Laser-assisted vessel welding: state of the art and future outlook. J CLIN TRANSL RES 2015;1 (2):61-77
  • Pabittei DR, Heger M, Simonet M, van Tuijl S, van der Wal AC, van Bavel ET, Laser-assisted vascular welding: optimization of acute and post-hydration welding strength. J CLIN TRANSL RES 2015;1:31-47
  • Pabittei DR, Heger M, van Tuijl S, Simonet M, de Boon W, van der Wal AC, Balm R, de Mol BA, Ex vivo proof-of-concept of end-to-end scaffold-enhanced laser-assisted vascular anastomosis of porcine arteries. J VASC SURG 2015;62 (1):200-209 [PubMed]
  • van Gemert MJC, Wagstaff PGK, de Bruin DM, van Leeuwen TG, van der Wal AC, Heger M, van der Geld CWM, Irreversible electroporation: just another form of thermal therapy?. PROSTATE 2015;75 (3):332-335 [PubMed]
  • van Golen RF, Reiniers MJ, Heger M, Verheij J, Solutions to the discrepancies in the extent of liver damage following ischemia/reperfusion in standard mouse models. J HEPATOL 2015;62 (4):975-977 [PubMed]
  • van Golen RF, Reiniers MJ, van Gulik TM, Heger M, Organ cooling in liver transplantation and resection: how low should we go?. HEPATOLOGY 2015;61 (1):395-399 [PubMed]
  • van Golen RF, Stevens KM, Colarusso P, Jaeschke H, Heger M, Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease. J CLIN TRANSL RES 2015;1 (2):107-115 [PubMed]
  • Weijer R, Broekgaarden M, Kos M, van Vught R, Rauws EAJ, Breukink E, van Gulik TM, Storm G, Heger M, Enhancing photodynamic therapy of refractory solid cancers: Combining second-generation photosensitizers with multi-targeted liposomal delivery. J PHOTOCH PHOTOBIO C 2015;23:103-131
  • Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AHC, van Gulik TM, Heger M, Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. BMC CANCER 2015;15 (1):1014 [PubMed]

2014

  • Cieslak KP, Runge JH, Heger M, Stoker J, Bennink RJ, van Gulik TM, New perspectives in the assessment of future remnant liver. DIGEST SURG 2014;31 (4-5):255-268 [PubMed]
  • Heger M, Thrombosis versus thermal coagulum formation as a result of endovenous laser treatment: biochemistry versus photophysics. PHLEBOLOGY 2014;29 (10):701-705 [PubMed]
  • Heger M, van Golen RF, Broekgaarden M, Michel MC, The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer. PHARMACOL REV 2014;66 (1):222-307 [PubMed]
  • Heger M, van Golen RF, Broekgaarden M, van den Bos RR, Neumann HAM, van Gulik TM, van Gemert MJC, Endovascular laser–tissue interactions and biological responses in relation to endovenous laser therapy. LASER MED SCI 2014;29 (2):405-422 [PubMed]
  • Oei GTML, Heger M, van Golen RF, Alles LK, Flick M, van der Wal AC, van Gulik TM, Hollmann MW, Preckel B, Weber NC, Reduction of cardiac cell death after helium postconditioning in rats: transcriptional analysis of cell death and survival pathways. MOL MED 2014;20:516-526 [PubMed]
  • Reiniers MJ, van Golen RF, Heger M, Mearadji B, Bennink RJ, Verheij J, van Gulik TM, In situ hypothermic perfusion with retrograde outflow during right hemihepatectomy: first experiences with a new technique. J AM COLL SURGEONS 2014;218 (1):e7-16 [PubMed]
  • Reiniers MJ, van Golen RF, van Gulik TM, Heger M, Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver. ANTIOXID REDOX SIGN 2014;21 (7):1119-1142 [PubMed]
  • van Golen RF, Reiniers MJ, Vrisekoop N, Zuurbier CJ, Olthof PB, van Rheenen J, van Gulik TM, Parsons BJ, Heger M, The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury. ANTIOXID REDOX SIGN 2014;21 (7):1098-1118 [PubMed]

2013

  • Broekgaarden M, de Kroon AIPM, Gulik TMv, Heger M, Development and in vitro proof-of-concept of interstitially targeted zinc- phthalocyanine liposomes for photodynamic therapy. CURR MED CHEM 2013;21 (3):377-391 [PubMed]
  • Bruinsma BG, Post ICJH, van Rijssen LB, de Boer L, Heger M, Zaat SAJ, van Gulik TM, Antibiotic prophylaxis in (sub)normothermic organ preservation: in vitro efficacy and toxicity of cephalosporins. TRANSPLANTATION 2013;95 (8):1064-1069 [PubMed]
  • Dirkes MC, Post ICJH, Heger M, van Gulik TM, A novel oxygenated machine perfusion system for preservation of the liver. ARTIF ORGANS 2013;37 (8):719-724 [PubMed]
  • Hoekstra LT, de Graaf W, Nibourg GAA, Heger M, Bennink RJ, Stieger B, van Gulik TM, Physiological and biochemical basis of clinical liver function tests: a review. ANN SURG 2013;257 (1):27-36 [PubMed]
  • Hoekstra LT, Ruys AT, Milstein DMJ, van Samkar G, van Berge Henegouwen MI, Heger M, Verheij J, van Gulik TM, Effects of prolonged pneumoperitoneum on hepatic perfusion during laparoscopy. ANN SURG 2013;257 (2):302-307 [PubMed]
  • Hoekstra LT, van Lienden KP, Verheij J, van der Loos CM, Heger M, van Gulik TM, Enhanced tumor growth after portal vein embolization in a rabbit tumor model. J SURG RES 2013;180 (1):89-96 [PubMed]
  • Marsman HA, de Graaf W, Heger M, van Golen RF, ten Kate FJW, Bennink R, van Gulik TM, Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids. BRIT J SURG 2013;100 (5):674-683 [PubMed]
  • Pabittei DR. Optimization of in vitro sutureless laser-assisted vascular anastomosis. s.l.: s.n.; 2013. 181p. ISBN 9789090273129 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de Mol BAJM, Legemate DA; copromotor(s): Balm R, Heger M)
  • Post ICJH. Preconditions for warm organ preservation. s.l.: s.n.; 2013. 235p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM; copromotor(s): Heger M)
  • Post ICJH, de Boon WMI, Heger M, van Wijk ACWA, Kroon J, van Buul JD, van Gulik TM, Endothelial cell preservation at hypothermic to normothermic conditions using clinical and experimental organ preservation solutions. EXP CELL RES 2013;319 (17):2501-2513 [PubMed]
  • Post ICJH, Dirkes MC, Heger M, Verheij J, de Bruin KM, de Korte D, Bennink RJ, van Gulik TM, Efficacy of liver graft washout as a function of the perfusate, pressure, and temperature. LIVER TRANSPLANT 2013;19 (8):843-851 [PubMed]
  • Post ICJH, Weenink RP, van Wijk ACWA, Heger M, Böing AN, van Hulst RA, van Gulik TM, Characterization and quantification of porcine circulating endothelial cells. XENOTRANSPLANTATION 2013;20 (1):18-26 [PubMed]
  • van Golen RF, Reiniers MJ, Olthof PB, van Gulik TM, Heger M, Sterile inflammation in hepatic ischemia/reperfusion injury: present concepts and potential therapeutics. J GASTROEN HEPATOL 2013;28 (3):394-400 [PubMed]

2012

  • Aguilar G, Choi B, Broekgaarden M, Yang O, Yang B, Ghasri P, Chen JK, Bezemer R, Nelson JS, van Drooge AM, Wolkerstorfer A, Kelly KM, Heger M, An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains. ANN BIOMED ENG 2012;40 (2):486-506 [PubMed]
  • Bezemer R, Dobbe JG, Bartels SA, Boerma EC, Elbers PWG, Heger M, Ince C, Rapid automatic assessment of microvascular density in sidestream dark field images (vol 49, pg 1269, 2011). MED BIOL ENG COMPUT 2012;50 (10):1115 [PubMed]
  • Chen JK, Ghasri P, Aguilar G, van Drooge AM, Wolkerstorfer A, Kelly KM, Heger M, An overview of clinical and experimental treatment modalities for port wine stains. J AM ACAD DERMATOL 2012;67 (2):289-+ [PubMed]
  • de Graaf W, Heger M, Spruijt O, Maas A, de Bruin K, Hoekstra R, Bennink RJ, van Gulik TM, Quantitative Assessment of Liver Function after Ischemia-Reperfusion Injury and Partial Hepatectomy in Rats. J SURG RES 2012;172 (1):85-94 [PubMed]
  • Kloek JJ, Maréchal X, Roelofsen J, Houtkooper RH, van Kuilenburg ABP, Kulik W, Bezemer R, Nevière R, van Gulik TM, Heger M, Cholestasis is associated with hepatic microvascular dysfunction and aberrant energy metabolism before and during ischemia-reperfusion. ANTIOXID REDOX SIGN 2012;17 (8):1109-1123 [PubMed]
  • Marsman HA. Hepatic steatosis in liver surgery: novel diagnostics and experimental therapy. s.l.: s.n.; 2012. 235p. ISBN 9789461911698 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM, Stoker J; copromotor(s): Heger M, Verhoef C)
  • Pabittei DR, Heger M, Simonet M, van Tuijl S, van der Wal AC, Beek JF, Balm R, de Mol BA, Biodegradable polymer scaffold, semi-solid solder, and single-spot lasing for increasing solder-tissue bonding in suture-free laser-assisted vascular repair. J TISSUE ENG REGEN M 2012;6 (10):803-812 [PubMed]
  • Post ICJH, Dirkes MC, Heger M, Bezemer R, van 't Leven J, van Gulik TM, Optimal Flow and Pressure Management in Machine Perfusion Systems for Organ Preservation. ANN BIOMED ENG 2012;40 (12):2698-2707 [PubMed]
  • Post ICJH, Dirkes MC, Heger M, van Loon JPAM, Swildens B, Huijzer GM, van Gulik TM, Appraisal of the porcine kidney autotransplantation model. FRONT BIOSCI (ELITE ED) 2012;4:1345-1357 [PubMed]
  • Reiniers MJ, van Golen RF, van Gulik TM, Heger M, 2 ',7 '-Dichlorofluorescein is not a probe for the detection of reactive oxygen and nitrogen species. J HEPATOL 2012;56 (5):1214-1216 [PubMed]
  • Stieger B, Heger M, de Graaf W, Paumgartner G, van Gulik T, The emerging role of transport systems in liver function tests. EUR J PHARMACOL 2012;675 (1-3):1-5 [PubMed]
  • van den Esschert JW, van Lienden KP, Alles LK, van Wijk AC, Heger M, Roelofs JJ, van Gulik TM, Liver Regeneration After Portal Vein Embolization Using Absorbable and Permanent Embolization Materials in a Rabbit Model. ANN SURG 2012;255 (2):311-318 [PubMed]
  • van Golen RF, van Gulik TM, Heger M, Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury. FREE RADICAL BIO MED 2012;52 (8):1382-1402 [PubMed]
  • van Golen RF, van Gulik TM, Heger M, The sterile immune response during hepatic ischemia/reperfusion. CYTOKINE GROWTH F R 2012;23 (3):69-84 [PubMed]
  • van Iterson M, Bezemer R, Heger M, Siegemund M, Ince C, Microcirculation follows macrocirculation in heart and gut in the acute phase of hemorrhagic shock and isovolemic autologous whole blood resuscitation in pigs. TRANSFUSION 2012;52 (7):1552-1559 [PubMed]
  • van Lienden KP, van den Esschert JW, Rietkerk M, Heger M, Roelofs JJTH, Lameris JS, van Gulik TM, Short-term Effects of Combined Hepatic Vein Embolization and Portal Vein Embolization for the Induction of Liver Regeneration in a Rabbit Model. J VASC INTERV RADIOL 2012;23 (7):962-967 [PubMed]

2011

  • Bartels SA, Bezemer R, de Vries FJW, Milstein DMJ, Lima A, Cherpanath TGV, van den Meiracker AH, van Bommel J, Heger M, Karemaker JM, Ince C, Multi-site and multi-depth near-infrared spectroscopy in a model of simulated (central) hypovolemia: lower body negative pressure. INTENS CARE MED 2011;37 (4):671-677 [PubMed]
  • Bartels SA, Bezemer R, Milstein DMJ, Radder M, Lima A, Cherpanath TGV, Heger M, Karemaker JM, Ince C, The microcirculatory response to compensated hypovolemia in a lower body negative pressure model. MICROVASC RES 2011;82 (3):374-380 [PubMed]
  • Bezemer R. Optical methods for the assessment of microvascular perfusion and oxygenation. s.l.: s.n.; 2011. 183p. ISBN 9789490371920 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Ince C; copromotor(s): Heger M)
  • Bezemer R, Dobbe JG, Bartels SA, Christiaan Boerma E, Elbers PWG, Heger M, Ince C, Rapid automatic assessment of microvascular density in sidestream dark field images. MED BIOL ENG COMPUT 2011;49 (11):1269-1278 [PubMed]
  • de Graaf W, Bennink RJ, Heger M, Maas A, de Bruin K, van Gulik TM, Quantitative Assessment of Hepatic Function During Liver Regeneration in a Standardized Rat Model. J NUCL MED 2011;52 (2):294-302 [PubMed]
  • de Graaf W, Häusler S, Heger M, van Ginhoven TM, van Cappellen G, Bennink RJ, Kullak-Ublick GA, Hesselmann R, van Gulik TM, Stieger B, Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. J HEPATOL 2011;54 (4):738-745 [PubMed]
  • Heger M, Marsman HA, Bezemer R, Cloos MA, van Golen RF, van Gulik TM, Non-invasive quantification of triglyceride content in steatotic rat livers by (1)H-MRS: when water meets (too much) fat. ACAD RADIOL 2011;18 (12):1582-1592 [PubMed]
  • Heger M, Salles II, Bezemer R, Cloos MA, Mordon SR, Bégu S, Deckmyn H, Beek JF, Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains. J DERMATOL SCI 2011;63 (3):139-147 [PubMed]
  • Marsman HA, Heger M, Kloek JJ, Nienhuis SL, ten Kate FJW, van Gulik TM, Omega-3 fatty acids reduce hepatic steatosis and consequently attenuate ischemia-reperfusion injury following partial hepatectomy in rats. DIGEST LIVER DIS 2011;43 (12):984-990 [PubMed]
  • Marsman HA, Heger M, Kloek JJ, Nienhuis SL, van Werven JR, Nederveen AJ, ten Kate FJW, Stoker J, van Gulik TM, Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by (1) H-magnetic resonance spectroscopy in a rat model. J GASTROEN HEPATOL 2011;26 (2):356-363 [PubMed]
  • Meuzelaar H, Heger M, Ariese F, van der Zwan G, No evidence for non-resonant optical frequency-induced effects on the intrinsic fluorescence of adenosine-5 '-triphosphate and the kinetics of the firefly luciferin-luciferase reaction. J PHOTOCH PHOTOBIO A 2011;223 (2-3):88-96
  • Pabittei DR, Heger M, Balm R, Meijer HEH, de Mol B, Beek JF, Electrospun Poly(ɛ-Caprolactone) Scaffold for Suture-Free Solder-Mediated Laser-Assisted Vessel Repair. PHOTOMED LASER SURG 2011;29 (1):19-25 [PubMed]
  • Pabittei DR, Heger M, Beek JF, van Tuijl S, Simonet M, van der Wal AC, de Mol BA, Balm R, Optimization of Suture-Free Laser-Assisted Vessel Repair by Solder-Doped Electrospun Poly(ε-caprolactone) Scaffold. ANN BIOMED ENG 2011;39 (1):223-234 [PubMed]
  • van den Esschert JW. Clinical and experimental studies on portal vein embolization / Diagnosis of hepatocellular adenoma and focal nodular hyperplasia. s.l.: s.n.; 2011. 247p. ISBN 9789461910554 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM; copromotor(s): Phoa SSKS, Heger M)
  • van den Esschert JW, van Lienden KP, de Graaf W, Maas MAW, Roelofs JJTH, Heger M, van Gulik TM, Portal vein embolization induces more liver regeneration than portal vein ligation in a standardized rabbit model. SURGERY 2011;149 (3):378-385 [PubMed]

2010

  • Bezemer R, Faber DJ, Almac E, Kalkman J, Legrand M , Heger M, Ince C, Evaluation of multi-exponential curve fitting analysis of oxygen-quenched phosphorescence decay traces for recovering microvascular oxygen tension histograms. MED BIOL ENG COMPUT 2010;48 (12):1233-1242 [PubMed]
  • Bezemer R, Klijn E, Khalilzada M, Lima A, Heger M, van Bommel J, Ince C, Validation of near-infrared laser speckle imaging for assessing microvascular (re)perfusion. MICROVASC RES 2010;79 (2):139-143 [PubMed]
  • Bezemer R, Legrand M , Klijn E, Heger M, Post ICJH, van Gulik TM, Payen D, Ince C, Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging. OPT EXPRESS 2010;18 (14):15054-15061 [PubMed]
  • Heger M, Response to letter to the editor. J PHOTOCH PHOTOBIO B 2010;98 (3):224 [PubMed]
  • Heger M, Bezemer R, Huertas-Pérez JF, Dekker H, Beek JF, Endovascular Laser-Tissue Interactions Redefined: Shining Light on Novel Windows of Therapeutic Opportunity Beyond Selective Photothermolysis. PHOTOMED LASER SURG 2010;28 (4):569-572 [PubMed]
  • Heger M, de Graaf W, Bennink RJ, Beuers U, van Gulik TM, A Clinical Perspective on the Criteria for Liver Resection and the Use of Liver Function Tests. WORLD J SURG 2010;34 (4):868-869 [PubMed]
  • Heger M, Heemskerk AAM, van der Zwan G, Absence of 633-nm laser irradiation-induced effects on glucose phosphorylation by hexokinase. J PHOTOCH PHOTOBIO B 2010;98 (3):216-222 [PubMed]
  • Kloek JJ. Experimental and clinical studies on the management of bile duct cancer. s.l.: s.n.; 2010. 256p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Gulik TM, Gouma DJ; copromotor(s): Heger M)
  • Kloek JJ, Heger M, van der Gaag NA, Beuers U, van Gulik TM, Gouma DJ, Levi M, Effect of Preoperative Biliary Drainage on Coagulation and Fibrinolysis in Severe Obstructive Cholestasis. J CLIN GASTROENTEROL 2010;44 (9):646-652 [PubMed]
  • Kloek JJ, Levi M, Heger M, van der Loos CM, Gouma DJ, van Gulik TM, Cholestasis enhances liver ischemia/reperfusion-induced coagulation activation in rats. HEPATOL RES 2010;40 (2):204-215 [PubMed]
  • Marsman HA, van Werven JR, Nederveen AJ, ten Kate FJ, Heger M, Stoker J, van Gulik TM, Noninvasive quantification of hepatic steatosis inrats using 3.0 T (1)H-magnetic resonance spectroscopy. J MAGN RESON IMAGING 2010;32 (1):148-154 [PubMed]

2009

  • Bezemer R, Karemaker JM, Klijn E, Martin D, Mitchell K, Grocott M, Heger M, Ince C, Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge. CRIT CARE 2009;13 (Suppl. 5):S5 [PubMed]
  • Bezemer R, Lima A, Myers D, Klijn E, Heger M, Goedhart PT, Bakker J, Ince C, Assessment of tissue oxygen saturation during a vascular occlusion test using near-infrared spectroscopy: the role of probe spacing and measurement site studied in healthy volunteers. CRIT CARE 2009;13 (Suppl. 5):S4 [PubMed]
  • Desmons S, Heger M, Delfosse C, Falgayrac G, Sarrazin T, Delattre C, Catros S, Mordon S, Penel G, A preliminary investigation into the effects of X-ray radiation on superficial cranial vascularization. CALCIFIED TISSUE INT 2009;84 (5):379-387 [PubMed]
  • Heger M. Lasers and liposomes: a potentially efficacious combination for the non-invasive removal of pathological cutaneous vasculature. s.l.: s.n.; 2009. 248p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Spaan JAE; copromotor(s): Beek JF)
  • Heger M, Salles II, de Kroon AIPM, Deckmyn H, Platelets and PEGylated lecithin liposomes: When stealth is allegedly picked up on the radar (and eaten). MICROVASC RES 2009;78 (1):1-3 [PubMed]
  • Heger M, Salles II, van Vuure W, Deckmyn H, Beek JF, Fluorescent labeling of platelets with polyanionic fluorescein derivatives. ANAL QUANT CYTOL 2009;31 (4):227-232 [PubMed]
  • Heger M, Salles II, van Vuure W, Hamelers IHL, Beek JF, de Kroon AIPM, Deckmyn H, On the interaction of fluorophore-encapsulating PEGylated lecithin liposomes with hamster and human platelets. MICROVASC RES 2009;78 (1):57-66 [PubMed]
  • Marsman HA, Al-Saady RL, Heger M, van Gulik TM, How reproducible are rat steatosis models using high-fat diets?. J HEPATOL 2009;51 (4):822-823 [PubMed]
  • van den Esschert JW, de Graaf W, van Lienden KP, Busch OR, Heger M, van Delden OM, Gouma DJ, Bennink RJ, Laméris JS, van Gulik TM, Volumetric and functional recovery of the remnant liver after major liver resection with prior portal vein embolization : recovery after PVE and liver resection. J GASTROINTEST SURG 2009;13 (8):1464-1469 [PubMed]

2008

  • van Gulik TM, van den Esschert JW, de Graaf W, van Lienden KP, Busch ORC, Heger M, van Delden OM, Laméris JS, Gouma DJ, Controversies in the use of portal vein embolization. DIGEST SURG 2008;25 (6):436-444 [PubMed]
  • Wolf-de Jonge ICDYM, Heger M, van Marle J, Balm R, Beek JF, Suture-free laser-assisted vessel repair using CO(2) laser and liquid albumin solder. J BIOMED OPT 2008;13 (4):044032 [PubMed]

2007

  • Bezemer R, Heger M, van den Wijngaard JPH, Mordon SR, van Gemert MJC, Beek JF, Laser-induced (endo)vascular photothermal effects studied by combined brightfield and fluorescence microscopy in hamster dorsal skin fold venules. OPT EXPRESS 2007;15 (14):8493-8506 [PubMed]
  • Huertas-Pérez JF, Heger M, Dekker H, Krabbe H, Lankelma J, Ariese F, Simple, rapid, and sensitive liquid chromatography-fluorescence method for the quantification of tranexamic acid in blood. J CHROMATOGR A 2007;1157 (1-2):142-150 [PubMed]

2006

  • Heger M, Mordon S, Leroy G, Fleurisse L, Creusy C, Raman microspectrometry of laser-reshaped rabbit auricular cartilage: preliminary study on laser-induced cartilage mineralization. J BIOMED OPT 2006;11 (2):024003 [PubMed]

2005

  • Heger M, Beek JF, Moldovan NI, van der Horst CMAM, van Gemert MJC, Towards optimization of selective photothermolysis: prothrombotic pharmaceutical agents as potential adjuvants in laser treatment of port wine stains - A theoretical study. THROMB HAEMOSTASIS 2005;93 (2):242-256 [PubMed]
  • Heger M, Beek J, Stenback K, Faber D, van Gemert M, Ince C, Darkfield orthogonal polarized spectral imaging for studying endovascular laser-tissue interactions in vivo - a preliminary study. OPT EXPRESS 2005;13 (3):702-715 [PubMed]