• Principal Investigator
  • Male

Prof. dr. J.P. Medema

Position: Professor
Main activities: Research
Specialisation: Experimental Oncology and Radiobiology
foto J.P. Medema is one of the AMC Principal Investigators
Focus of research:
  • Cancer stem cells
  • Colon Cancer, prognosis, novel therapies and therapy resistance
  • Apoptosis/Cell death mechanisms
  • TNF family members
  • Radiation damage
AMC themes: Oncology
Departments: Center of Experimental and Molecular Medicine, Radiotherapy
Ebbing EA, Steins A, Fessler E, Stathi P, Lesterhuis WJ, Krishnadath KK, Vermeulen L, Medema JP, Bijlsma MF, van Laarhoven HWM, Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition. GASTROENTEROLOGY 2017;153 (1):63-76.e14 [PubMed]
García-Laorden MI, Stroo I, Terpstra S, Florquin S, Medema JP, van T Veer C, de Vos AF, van der Poll T, Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis. MEDIAT INFLAMM 2017;2017:4137563 [PubMed]
Kandimalla R, Linnekamp JF, van Hooff S, Castells A, Llor X, Andreu M, Jover R, Goel A, Medema JP, Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. ONCOGENESIS 2017;6 (4):e308 [PubMed]
Linnekamp JF, Butter R, Spijker R, Medema JP, van Laarhoven HWM, Clinical and biological effects of demethylating agents on solid tumours - A systematic review. CANCER TREAT REV 2017;54:10-23 [PubMed]
Medema JP, Targeting the Colorectal Cancer Stem Cell. NEW ENGL J MED 2017;377 (9):888-890 [PubMed]
Oei AL. Tumor cells can’t stand the heat: Boosting the effectiveness of hyperthermia in cervical carcinoma. S.l.: s.n.; 2017. 299p. ISBN 978-94-6295-510-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP, Stalpers LJA; copromotor(s): Franken NAP, Kok HP)
Prasetyanti PR, Medema JP, Intra-tumor heterogeneity from a cancer stem cell perspective. MOL CANCER 2017;16 (1):41 [PubMed]
Than BLN, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Walter J, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJA, Meijer GA, van den Broek E, Hodges CA, Scott PM, Vermeulen L, Cormier RT, CFTR is a tumor suppressor gene in murine and human intestinal cancer. ONCOGENE 2017;36 (24):3504 [PubMed]
Trinh A, Trumpi K, de Sousa E Melo F, Wang X, de Jong JH, Fessler E, Kuppen PJK, Reimers MS, Swets M, Koopman M, Nagtegaal ID, Jansen M, Hooijer GKJ, Offerhaus GJA, Kranenburg O, Punt CJ, Medema JP, Markowetz F, Vermeulen L, Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry. CLIN CANCER RES 2017;23 (2):387-398 [PubMed]
Trumpi K, Ubink I, Trinh A, Djafarihamedani M, Jongen JM, Govaert KM, Elias SG, van Hooff SR, Medema JP, Lacle MM, Vermeulen L, Borel Rinkes IHM, Kranenburg O, Neoadjuvant chemotherapy affects molecular classification of colorectal tumors. ONCOGENESIS 2017;6 (7):e357 [PubMed]
van Oorschot B, Uitterhoeve L, Oomen I, ten Cate R, Medema JP, Vrieling H, Stalpers LJA, Moerland PD, Franken NAP, Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination. CANCER RES 2017;77 (6):1485-1491 [PubMed]
Veenstra VL, Damhofer H, Waasdorp C, Steins A, Kocher HM, Medema JP, van Laarhoven HW, Bijlsma MF, Stromal SPOCK1 supports invasive pancreatic cancer growth. MOL ONCOL 2017;11 (8):1050-1064 [PubMed]
Colak S. Targeting cancer stem cells: Modulating apoptosis and stemness. S.l.: s.n.; 2016. 235p. ISBN 978-94-028-0195-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): van den Brink GR)
Colak S, Medema JP, Human colonic fibroblasts regulate stemness and chemotherapy resistance of colon cancer stem cells. CELL CYCLE 2016;15 (12):1531-1537 [PubMed]
den Uil SH, Coupé VMH, Linnekamp JF, van den Broek E, Goos JACM, Delis-van Diemen PM, Belt EJT, van Grieken NCT, Scott PM, Vermeulen L, Medema JP, Bril H, Stockmann HBAC, Cormier RT, Meijer GA, Fijneman RJA, Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence. BRIT J CANCER 2016;115 (12):1565-1574 [PubMed]
Di Franco S, Turdo A, Benfante A, Colorito ML, Gaggianesi M, Apuzzo T, Kandimalla R, Chinnici A, Barcaroli D, Mangiapane LR, Pistone G, Vieni S, Gulotta E, Dieli F, Medema JP, Stassi G, de Laurenzi V, Todaro M, ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis. ONCOTARGET 2016;7 (34):54157-54173 [PubMed]
Domingo E, Freeman-Mills L, Rayner E, Glaire M, Briggs S, Vermeulen L, Fessler E, Medema JP, Boot A, Morreau H, van Wezel T, Liefers GJ, Lothe RA, Danielsen SA, Sveen A, Nesbakken A, Zlobec I, Lugli A, Koelzer VH, Berger MD, Castellví-Bel S, Muñoz J, de Bruyn M, Nijman HW, Novelli M, Lawson K, Oukrif D, Frangou E, Dutton P, Tejpar S, Delorenzi M, Kerr R, Kerr D, Tomlinson I, Church DN, Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study. LANCET GASTROENTEROL HEPATOL 2016;1 (3):207-216 [PubMed]
Ebbing EA, Medema JP, Damhofer H, Meijer SL, Krishnadath KK, van Berge Henegouwen MI, Bijlsma MF, van Laarhoven HWM, ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3. ONCOTARGET 2016;7 (9):10243-10254 [PubMed]
Fessler E. Exploring tumor heterogeneity. S.l.: s.n.; 2016. 196p. ISBN 978-94-6295-379-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Vermeulen L)
Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, de Sousa E Melo F, Prasetyanti PR, IJspeert JE, Franitza M, Nürnberg P, van Noesel CJ, Dekker E, Vermeulen L, Clevers H, Medema JP, TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO MOL MED 2016;8 (7):745-760 [PubMed]
Fessler E, Jansen M, de Sousa E Melo F, Zhao L, Prasetyanti PR, Rodermond H, Kandimalla R, Linnekamp JF, Franitza M, van Hooff SR, de Jong JH, Oppeneer SC, van Noesel CJM, Dekker E, Stassi G, Wang X, Medema JP, Vermeulen L, A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype. ONCOGENE 2016;35 (46):6026-6037 [PubMed]
Fessler E, Medema JP, Colorectal Cancer Subtypes: Developmental Origin and Microenvironmental Regulation. TRENDS CANCER 2016;2 (9):505-518 [PubMed]
García-Laorden MI, Stroo I, Blok DC, Florquin S, Medema JP, de Vos AF, van der Poll T, Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia. J INNATE IMMUN 2016;8 (3):258-268 [PubMed]
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RCC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SSL, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CHA, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RCBQ, de la Fuente J, de Martino L, de Matteis A, de Meyer GR, de Milito A, de Santi M, de Souza W, de Tata V, de Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, del Bello B, del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM Jr, Doran KS, D'Orazi G, Dorn GW 2nd, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA Jr, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM Jr, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÅB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, Harris AL, Harris J, Hasler U, Hasselblatt P, Hasui K, Hawley RG, Hawley TS, He C, He CY, He F, He G, He RR, He XH, He YW, He YY, Heath JK, Hébert MJ, Heinzen RA, Helgason GV, Hensel M, Henske EP, Her C, Herman PK, Hernández A, Hernandez C, Hernández-Tiedra S, Hetz C, Hiesinger PR, Higaki K, Hilfiker S, Hill BG, Hill JA, Hill WD, Hino K, Hofius D, Hofman P, Höglinger GU, Höhfeld J, Holz MK, Hong Y, Hood DA, Hoozemans JJ, Hoppe T, Hsu C, Hsu CY, Hsu LC, Hu D, Hu G, Hu HM, Hu H, Hu MC, Hu YC, Hu ZW, Hua F, Hua Y, Huang C, Huang HL, Huang KH, Huang KY, Huang S, Huang S, Huang WP, Huang YR, Huang Y, Huang Y, Huber TB, Huebbe P, Huh WK, Hulmi JJ, Hur GM, Hurley JH, Husak Z, Hussain SN, Hussain S, Hwang JJ, Hwang S, Hwang TI, Ichihara A, Imai Y, Imbriano C, Inomata M, Into T, Iovane V, Iovanna JL, Iozzo RV, Ip NY, Irazoqui JE, Iribarren P, Isaka Y, Isakovic AJ, Ischiropoulos H, Isenberg JS, Ishaq M, Ishida H, Ishii I, Ishmael JE, Isidoro C, Isobe Ki, Isono E, Issazadeh-Navikas S, Itahana K, Itakura E, Ivanov AI, Iyer AKV, Izquierdo JM, Izumi Y, Izzo V, Jäättelä M, Jaber N, Jackson DJ, Jackson WT, Jacob TG, Jacques TS, Jagannath C, Jain A, Jana NR, Jang BK, Jani A, Janji B, Jannig PR, Jansson PJ, Jean S, Jendrach M, Jeon JH, Jessen N, Jeung EB, Jia K, Jia L, Jiang H, Jiang H, Jiang L, Jiang T, Jiang X, Jiang X, Jiang Y, Jiang Y, Jiménez A, Jin C, Jin H, Jin L, Jin M, Jin S, Jinwal UK, Jo EK, Johansen T, Johnson DE, Johnson GV, Johnson JD, Jonasch E, Jones C, Joosten LA, Jordan J, Joseph AM, Joseph B, Joubert AM, Ju D, Ju J, Juan HF, Juenemann K, Juhász G, Jung HS, Jung JU, Jung YK, Jungbluth H, Justice MJ, Jutten B, Kaakoush NO, Kaarniranta K, Kaasik A, Kabuta T, Kaeffer B, Kågedal K, Kahana A, Kajimura S, Kakhlon O, Kalia M, Kalvakolanu DV, Kamada Y, Kambas K, Kaminskyy VO, Kampinga HH, Kandouz M, Kang C, Kang R, Kang TC, Kanki T, Kanneganti TD, Kanno H, Kanthasamy AG, Kantorow M, Kaparakis-Liaskos M, Kapuy O, Karantza V, Karim MR, Karmakar P, Kaser A, Kaushik S, Kawula T, Kaynar AM, Ke PY, Ke ZJ, Kehrl JH, Keller KE, Kemper JK, Kenworthy AK, Kepp O, Kern A, Kesari S, Kessel D, Ketteler R, Kettelhut IdC, Khambu B, Khan MM, Khandelwal VK, Khare S, Kiang JG, Kiger AA, Kihara A, Kim AL, Kim CH, Kim DR, Kim DH, Kim EK, Kim HY, Kim HR, Kim JS, Kim JH, Kim JC, Kim JH, Kim KW, Kim MD, Kim MM, Kim PK, Kim SW, Kim SY, Kim YS, Kim Y, Kimchi A, Kimmelman AC, Kimura T, King JS, Kirkegaard K, Kirkin V, Kirshenbaum LA, Kishi S, Kitajima Y, Kitamoto K, Kitaoka Y, Kitazato K, Kley RA, Klimecki WT, Klinkenberg M, Klucken J, Knævelsrud H, Knecht E, Knuppertz L, Ko JL, Kobayashi S, Koch JC, Koechlin-Ramonatxo C, Koenig U, Koh YH, Köhler K, Kohlwein SD, Koike M, Komatsu M, Kominami E, Kong D, Kong HJ, Konstantakou EG, Kopp BT, Korcsmaros T, Korhonen L, Korolchuk VI, Koshkina NV, Kou Y, Koukourakis MI, Koumenis C, Kovács AL, Kovács T, Kovacs WJ, Koya D, Kraft C, Krainc D, Kramer H, Kravic-Stevovic T, Krek W, Kretz-Remy C, Krick R, Krishnamurthy M, Kriston-Vizi J, Kroemer G, Kruer MC, Kruger R, Ktistakis NT, Kuchitsu K, Kuhn C, Kumar AP, Kumar A, Kumar A, Kumar D, Kumar D, Kumar R, Kumar S, Kundu M, Kung HJ, Kuno A, Kuo SH, Kuret J, Kurz T, Kwok T, Kwon TK, Kwon YT, Kyrmizi I, La Spada AR, Lafont F, Lahm T, Lakkaraju A, Lam T, Lamark T, Lancel S, Landowski TH, Lane DJR, Lane JD, Lanzi C, Lapaquette P, Lapierre LR, Laporte J, Laukkarinen J, Laurie GW, Lavandero S, Lavie L, LaVoie MJ, Law BYK, Law HKW, Law KB, Layfield R, Lazo PA, Le Cam L, Le Roch KG, Le Stunff H, Leardkamolkarn V, Lecuit M, Lee BH, Lee CH, Lee EF, Lee GM, Lee HJ, Lee H, Lee JK, Lee J, Lee JH, Lee JH, Lee M, Lee MS, Lee PJ, Lee SW, Lee SJ, Lee SJ, Lee SY, Lee SH, Lee SS, Lee SJ, Lee S, Lee YR, Lee YJ, Lee YH, Leeuwenburgh C, Lefort S, Legouis R, Lei J, Lei QY, Leib DA, Leibowitz G, Lekli I, Lemaire SD, Lemasters JJ, Lemberg MK, Lemoine A, Leng S, Lenz G, Lenzi P, Lerman LO, Lettieri Barbato D, Leu JIJ, Leung HY, Levine B, Lewis PA, Lezoualc'h F, Li C, Li F, Li FJ, Li J, Li K, Li L, Li M, Li Q, Li R, Li S, Li W, Li X, Li Y, Lian J, Liang C, Liang Q, Liao Y, Liberal J, Liberski PP, Lie P, Lieberman AP, Lim HJ, Lim KL, Lim K, Lima RT, Lin CS, Lin CF, Lin F, Lin F, Lin FC, Lin K, Lin KH, Lin PH, Lin T, Lin WW, Lin YS, Lin Y, Linden R, Lindholm D, Lindqvist LM, Lingor P, Linkermann A, Liotta LA, Lipinski MM, Lira VA, Lisanti MP, Liton PB, Liu B, Liu C, Liu CF, Liu F, Liu HJ, Liu J, Liu JJ, Liu JL, Liu K, Liu L, Liu L, Liu Q, Liu RY, Liu S, Liu S, Liu W, Liu XD, Liu X, Liu XH, Liu X, Liu X, Liu X, Liu Y, Liu Y, Liu Z, Liu Z, Liuzzi JP, Lizard G, Ljujic M, Lodhi IJ, Logue SE, Lokeshwar BL, Long YC, Lonial S, Loos B, López-Otín C, López-Vicario C, Lorente M, Lorenzi PL, Lõrincz P, Los M, Lotze MT, Lovat PE, Lu B, Lu B, Lu J, Lu Q, Lu SM, Lu S, Lu Y, Luciano F, Luckhart S, Lucocq JM, Ludovico P, Lugea A, Lukacs NW, Lum JJ, Lund AH, Luo H, Luo J, Luo S, Luparello C, Lyons T, Ma J, Ma Y, Ma Y, Ma Z, Machado J, Machado-Santelli GM, Macian F, MacIntosh GC, MacKeigan JP, Macleod KF, MacMicking JD, MacMillan-Crow LA, Madeo F, Madesh M, Madrigal-Matute J, Maeda A, Maeda T, Maegawa G, Maellaro E, Maes H, Magariños M, Maiese K, Maiti TK, Maiuri L, Maiuri MC, Maki CG, Malli R, Malorni W, Maloyan A, Mami-Chouaib F, Man N, Mancias JD, Mandelkow EM, Mandell MA, Manfredi AA, Manié SN, Manzoni C, Mao K, Mao Z, Mao ZW, Marambaud P, Marconi AM, Marelja Z, Marfe G, Margeta M, Margittai E, Mari M, Mariani FV, Marin C, Marinelli S, Mariño G, Markovic I, Marquez R, Martelli AM, Martens S, Martin KR, Martin SJ, Martin S, Martin-Acebes MA, Martín-Sanz P, Martinand-Mari C, Martinet W, Martinez J, Martinez-Lopez N, Martinez-Outschoorn U, Martínez-Velázquez M, Martinez-Vicente M, Martins WK, Mashima H, Mastrianni JA, Matarese G, Matarrese P, Mateo R, Matoba S, Matsumoto N, Matsushita T, Matsuura A, Matsuzawa T, Mattson MP, Matus S, Maugeri N, Mauvezin C, Mayer A, Maysinger D, Mazzolini GD, McBrayer MK, McCall K, McCormick C, McInerney GM, McIver SC, McKenna S, McMahon JJ, McNeish IA, Mechta-Grigoriou F, Medema JP, Medina DL, Megyeri K, Mehrpour M, Mehta JL, Mei Y, Meier UC, Meijer AJ, Meléndez A, Melino G, Melino S, de Melo EJT, Mena MA, Meneghini MD, Menendez JA, Menezes R, Meng L, Meng LH, Meng S, Menghini R, Menko AS, Menna-Barreto RF, Menon MB, Meraz-Ríos MA, Merla G, Merlini L, Merlot AM, Meryk A, Meschini S, Meyer JN, Mi MT, Miao CY, Micale L, Michaeli S, Michiels C, Migliaccio AR, Mihailidou AS, Mijaljica D, Mikoshiba K, Milan E, Miller-Fleming L, Mills GB, Mills IG, Minakaki G, Minassian BA, Ming XF, Minibayeva F, Minina EA, Mintern JD, Minucci S, Miranda-Vizuete A, Mitchell CH, Miyamoto S, Miyazawa K, Mizushima N, Mnich K, Mograbi B, Mohseni S, Moita LF, Molinari M, Molinari M, Møller AB, Mollereau B, Mollinedo F, Mongillo M, Monick MM, Montagnaro S, Montell C, Moore DJ, Moore MN, Mora-Rodriguez R, Moreira PI, Morel E, Morelli MB, Moreno S, Morgan MJ, Moris A, Moriyasu Y, Morrison JL, Morrison LA, Morselli E, Moscat J, Moseley PL, Mostowy S, Motori E, 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AUTOPHAGY 2016;12 (1):1-222 [PubMed]
Lam K, Pan K, Linnekamp JF, Medema JP, Kandimalla R, DNA methylation based biomarkers in colorectal cancer: A systematic review. BBA-BIOENERGETICS 2016;1866 (1):106-120 [PubMed]
Potze L, Di Franco S, Grandela C, Pras-Raves ML, Picavet DI, van Veen HA, van Lenthe H, Mullauer FB, van der Wel NN, Luyf A, van Kampen AHC, Kemp S, Everts V, Kessler JH, Vaz FM, Medema JP, Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification. ONCOGENE 2016;35 (4):427-437 [PubMed]
Potze L, Di Franco S, Kessler JH, Stassi G, Medema JP, Betulinic Acid Kills Colon Cancer Stem Cells. CURR STEM CELL RES T 2016;11 (5):427-433 [PubMed]
Than BLN, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJA, Meijer GA, van den Broek E, Hodges CA, Scott PM, Vermeulen L, Cormier RT, CFTR is a tumor suppressor gene in murine and human intestinal cancer. ONCOGENE 2016;35 (32):4179-4187 [PubMed]
van den Boogaard FE, van Gisbergen KPJM, Vernooy JH, Medema JP, Roelofs JJTH, van Zoelen MAD, Endeman H, Biesma DH, Boon L, van't Veer C, de Vos AF, van der Poll T, Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia. AM J PHYSIOL-LUNG C 2016;311 (2):L507-L516 [PubMed]
van der Heijden M, Zimberlin CD, Nicholson AM, Colak S, Kemp R, Meijer SL, Medema JP, Greten FR, Jansen M, Winton DJ, Vermeulen L, Bcl-2 is a critical mediator of intestinal transformation. NAT COMMUN 2016;7:10916 [PubMed]
van Oorschot B. Tumor control and normal tissue toxicity: The two faces of radiotherapy. S.l.: s.n.; 2016. 165p. ISBN 978-94-6182-710-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP, Stalpers LJA; copromotor(s): Franken NAP, Vrieling H)
van Oorschot B, Granata G, Di Franco S, ten Cate R, Rodermond HM, Todaro M, Medema JP, Franken NAP, Targeting dna double strand break repair with hyperthermia and dna-pkcs inhibition to enhance the effect of radiation treatment. ONCOTARGET 2016;7 (40):65504-65513 [PubMed]
Vellinga TT, den Uil S, Rinkes IHB, Marvin D, Ponsioen B, Alvarez-Varela A, Fatrai S, Scheele C, Zwijnenburg DA, Snippert H, Vermeulen L, Medema JP, Stockmann HB, Koster J, Fijneman RJA, de Rooij J, Kranenburg O, Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion. ONCOGENE 2016;35 (40):5263-5271 [PubMed]
Zimberlin CD. Crossing Borders: Manipulating stemness through carcinogenesis. S.l.: s.n.; 2016. 221p. ISBN 978-94-6182-676-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Vermeulen L, Bots M)
Büller NVJA, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JLM, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GRAM, Wildenberg ME, de Sauvage FJ, Muncan V , van den Brink GR, Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice. GASTROENTEROLOGY 2015;148 (1):170-180.e6 [PubMed]
Calpe S, Wagner K, El Khattabi M, Rutten L, Zimberlin C, Dolk E, Verrips CT, Medema JP, Spits H, Krishnadath KK, Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies. MOL CANCER THER 2015;14 (11):2527-2540 [PubMed]
Damhofer H. Opening new doors: Hedgehog signaling and the pancreatic cancer stroma. S.l.: s.n.; 2015. 191p. ISBN 978-94-6182-545-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Bijlsma MF)
Damhofer H, Ebbing EA, Steins A, Welling L, Tol JA, Krishnadath KK, van Leusden T, van de Vijver MJ, Besselink MG, Busch OR, van Berge Henegouwen MI, van Delden O, Meijer SL, Dijk F, Medema JP, van Laarhoven HW, Bijlsma MF, Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract. J TRANSL MED 2015;13 (1):115 [PubMed]
Damhofer H, Veenstra VL, Tol JAMG, van Laarhoven HWM, Medema JP, Bijlsma MF, Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency. J CELL SCI 2015;128 (1):129-139 [PubMed]
Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, Snippert HJ, Medema JP, Kops GJPL, Clevers H, Sequential cancer mutations in cultured human intestinal stem cells. NATURE 2015;521 (7550):43-37 [PubMed]
Fessler E, Borovski T, Medema JP, Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF. MOL CANCER 2015;14 (1):157 [PubMed]
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, de Laurenzi V, de Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G, Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. CELL DEATH DIFFER 2015;22 (1):58-73 [PubMed]
Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, de Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S, The consensus molecular subtypes of colorectal cancer. NAT MED 2015;21 (11):1350-1356 [PubMed]
IJspeert JEG, Medema JP, Dekker E, Colorectal neoplasia pathways: state of the art. GASTROINTEST ENDOSC CLIN N AM 2015;25 (2):169-182 [PubMed]
Lascano V, Hahne M, Papon L, Cameron K, Röeder C, Schafmayer C, Driessen L, van Eenennaam H, Kalthoff H, Medema JP, Circulating APRIL levels are correlated with advanced disease and prognosis in rectal cancer patients. ONCOGENESIS 2015;4:e136 [PubMed]
Linnekamp JF, Wang X, Medema JP, Vermeulen L, Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes. CANCER RES 2015;75 (2):245-249 [PubMed]
Oei AL, van Leeuwen CM, ten Cate R, Rodermond HM, Buist MR, Stalpers LJA, Crezee J, Kok HP, Medema JP, Franken NAP, Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis. CANCER RES 2015;75 (23):5120-5129 [PubMed]
Potze L. Mechanisms of Betulinic acid-induced cell death. S.l.: s.n.; 2015. 199p. ISBN 978-94-6299-201-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Kessler JH, Vaz FM)
Prasetyanti PR, Capone E, Barcaroli D, D'Agostino D, Volpe S, Benfante A, van Hooff S, Iacobelli V, Rossi C, Iacobelli S, Medema JP, de Laurenzi V, Sala G, ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs). ONCOTARGET 2015;6 (19):16902-16911 [PubMed]
Tirinato L, Liberale C, Di Franco S, Candeloro P, Benfante A, La Rocca R, Potze L, Marotta R, Ruffilli R, Rajamanickam VP, Malerba M, de Angelis F, Falqui A, Carbone E, Todaro M, Medema JP, Stassi G, Di Fabrizio E, Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging. STEM CELLS 2015;33 (1):35-44 [PubMed]
Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR, ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. CELL REP 2015;13 (3):490-494 [PubMed]
Zimberlin CD, Lancini C, Sno R, Rosekrans SL, McLean CM, Vlaming H, van den Brink GR, Bots M, Medema JP, Dannenberg JH, HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis. FASEB J 2015;29 (5):2070-2080 [PubMed]
Colak S, Medema JP, Cancer stem cells--important players in tumor therapy resistance. FEBS J 2014;281 (21):4779-4791 [PubMed]
Colak S, Zimberlin CD, Fessler E, Hogdal L, Prasetyanti PR, Grandela CM, Letai A, Medema JP, Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells. CELL DEATH DIFFER 2014;21 (7):1170-1177 [PubMed]
Grabinger T, Luks L, Kostadinova F, Zimberlin C, Medema JP, Leist M, Brunner T, Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy. CELL DEATH DIS 2014;5:e1228 [PubMed]
Lascano V. The role of APRIL (TNFSF13) in carcinogenesis. S.l.: s.n.; 2014. 167p. ISBN 9789461825063 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): )
Medema JP, Welcome to the next step for Oncogenesis. ONCOGENESIS 2014;3:e130 [PubMed]
Potze L, Mullauer FB, Colak S, Kessler JH, Medema JP, Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response. CELL DEATH DIS 2014;5:e1169 [PubMed]
Rocha C, Papon L, Cacheux W, Marques Sousa P, Lascano V, Tort O, Giordano T, Vacher S, Lemmers B, Mariani P, Meseure D, Medema JP, Bièche I, Hahne M, Janke C, Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. EMBO J 2014;33 (19):2247-2260 [PubMed]
Rocha C, Papon L, Cacheux W, Marques Sousa P, Lascano V, Tort O, Giordano T, Vacher S, Lemmers B, Mariani P, Meseure D, Medema JP, Bièche I, Hahne M, Janke C, Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon (vol 33, pg 2247, 2014). EMBO J 2014;33 (22):2735 [PubMed]
Sadanandam A, Wang X, de Sousa E Melo F, Gray JW, Vermeulen L, Hanahan D, Medema JP, Reconciliation of classification systems defining molecular subtypes of colorectal cancer: interrelationships and clinical implications. CELL CYCLE 2014;13 (3):353-357 [PubMed]
van Oorschot B, Hovingh SE, Moerland PD, Medema JP, Stalpers LJA, Vrieling H, Franken NAP, Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity. INT J RADIAT ONCOL 2014;88 (3):664-670 [PubMed]
Balzarolo M. On the TRAIL of innate immune responses. Plasmacytoid dendritic cells and beyond. s.l.: s.n.; 2013. 155p. ISBN 9789461823120 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Wolkers MC)
Balzarolo M, Watzl C, Medema JP, Wolkers MC, NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells. IMMUNOL LETT 2013;151 (1-2):61-67 [PubMed]
Bergs JWJ, Krawczyk PM, Borovski T, ten Cate R, Rodermond HM, Stap J, Medema JP, Haveman J, Essers J, van Bree C, Stalpers LJA, Kanaar R, Aten JA, Franken NAP, Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining. DNA REPAIR 2013;12 (1):38-45 [PubMed]
Borovski T, Beke P, van Tellingen O, Rodermond HM, Verhoeff JJ, Lascano V, Daalhuisen JB, Medema JP, Sprick MR, Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme. ONCOGENE 2013;32 (12):1539-1548 [PubMed]
Damhofer H, Medema JP, Veenstra VL, Badea L, Popescu I, Roelink H, Bijlsma MF, Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma. MOL ONCOL 2013;7 (6):1031-1042 [PubMed]
de Sousa E Melo F. Colon cancer heterogeneity: stem cells, signals and subtypes. s.l.: s.n.; 2013. 203p. ISBN 98789461823267 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Vermeulen L)
de Sousa E Melo F, Vermeulen L, Fessler E, Medema JP, Cancer heterogeneity--a multifaceted view. EMBO REP 2013;14 (8):686-695 [PubMed]
de Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LPMH, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJM, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L, Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. NAT MED 2013;19 (5):614-618 [PubMed]
Fernandez L, Salinas GF, Rocha C, Carvalho-Pinto CE, Yeremenko N, Papon L, Medema JP, Combe B, Morel J, Baeten D, Hahne M, The TNF family member APRIL dampens collagen-induced arthritis. ANN RHEUM DIS 2013;72 (8):1367-1374 [PubMed]
Fessler E, Dijkgraaf FE, de Sousa E Melo F, Medema JP, Cancer stem cell dynamics in tumor progression and metastasis: Is the microenvironment to blame?. CANCER LETT 2013;341 (1):97-104 [PubMed]
Guadagnoli M. Targeting APRIL. s.l.: s.n.; 2013. 135p. ISBN 9789461822802 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): )
Huels DJ, Cammareri P, Ridgway RA, Medema JP, Sansom OJ, Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis. METHODS MOL BIOL 2013;1012:237-248 [PubMed]
Lascano V, Guadagnoli M, Schot JG, Luijks DM, Guikema JEJ, Cameron K, Hahne M, Pals S, Slinger E, Kipps TJ, van Oers MHJ, Eldering E, Medema JP, Kater AP, Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model. BLOOD 2013;122 (24):3960-3963 [PubMed]
Medema JP, Cancer stem cells: the challenges ahead. NAT CELL BIOL 2013;15 (4):338-344 [PubMed]
Prasetyanti PR, Zimberlin CD, Bots M, Vermeulen L, Melo FDSE, Medema JP, Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon. MOL CANCER 2013;12 (1):126 [PubMed]
Prasetyanti PR, Zimberlin C, de Sousa E Melo F, Medema JP, Isolation and propagation of colon cancer stem cells. METHODS MOL BIOL 2013;1035:247-259 [PubMed]
Vermeulen L, Medema JP. De pathogenese van dikkedarmkanker in: Punt CJA, Marijnen CAM, Nagtegaal ID, van de Velde CJH, editors. Handboek colorectaal carcinoom. Utrecht: De Tijdstroom; 2013., p. 37-46
Wang X, Markowetz F, de Sousa E Melo F, Medema JP, Vermeulen L, Dissecting cancer heterogeneity--an unsupervised classification approach. INT J BIOCHEM CELL B 2013;45 (11):2574-2579 [PubMed]
Zeilstra J, Joosten SPJ, Vermeulen L, Koster J, Medema JP, Versteeg R, Spaargaren M, Pals ST, CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status. PLOS ONE 2013;8 (8):e72849 [PubMed]
Balzarolo M, Karrich JJ, Engels S, Blom B, Medema JP, Wolkers MC, The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs. EUR J IMMUNOL 2012;42 (11):3019-3027 [PubMed]
Borovski T. Cancer stem cell niche: the place to be. s.l.: s.n.; 2012. 157p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Sprick MR , Franken NAP)
de Jong JH, Rodermond HM, Zimberlin CD, Lascano V, de Sousa E Melo F, Richel DJ, Medema JP, Vermeulen L, Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis. SCI REP-UK 2012;2:271 [PubMed]
de Sousa E Melo F, Medema JP, Axing Wnt signals. CELL RES 2012;22 (1):9-11 [PubMed]
Kemper K. Molecular identification and targeting of colorectal cancer stem cells. s.l.: s.n.; 2012. 182p. ISBN 9789085707882 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): )
Kemper K, Medema JP, Prognostic Value of CD133 Caused by Mutant K-Ras and B-Raf-Response. CLIN CANCER RES 2012;18 (16):4474 [PubMed]
Kemper K, Prasetyanti PR, de Lau W, Rodermond H, Clevers H, Medema JP, Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells. STEM CELLS 2012;30 (11):2378-2386 [PubMed]
Kemper K, Rodermond H, Colak S, Grandela C, Medema JP, Targeting colorectal cancer stem cells with inducible caspase-9. APOPTOSIS 2012;17 (5):528-537 [PubMed]
Kemper K, Versloot M, Cameron K, Colak S, de Sousa E Melo F, de Jong JH, Bleackley J, Vermeulen L, Versteeg R, Koster J, Medema JP, Mutations in the Ras-Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer. CLIN CANCER RES 2012;18 (11):3132-3141 [PubMed]
Kimberley FC, van der Sloot AM, Guadagnoli M, Cameron K, Schneider P, Marquart JA, Versloot M, Serrano L, Medema JP, The Design and Characterization of Receptor-selective APRIL Variants. J BIOL CHEM 2012;287 (44):37434-37446 [PubMed]
Krawczyk PM, Borovski T, Stap J, Cijsouw T, ten Cate R, Medema JP, Kanaar R, Franken NAP, Aten JA, Chromatin mobility is increased at sites of DNA double-strand breaks. J CELL SCI 2012;125 (9):2127-2133 [PubMed]
Lascano V, Zabalegui LF, Cameron K, Guadagnoli M, Jansen M, Burggraaf M, Versloot M, Rodermond H, van der Loos C, Carvalho-Pinto CE, Kalthoff H, Medema JP, Hahne M, The TNF family member APRIL promotes colorectal tumorigenesis. CELL DEATH DIFFER 2012;19 (11):1826-1835 [PubMed]
Rosati A, Bersani S, Tavano F, Dalla Pozza E, de Marco M, Palmieri M, de Laurenzi V, Franco R, Scognamiglio G, Palaia R, Fontana A, di Sebastiano P, Donadelli M, Dando I, Medema JP, Dijk F, Welling L, di Mola FF, Pezzilli R, Turco MC, Scarpa A, Expression of the Antiapoptotic Protein BAG3 Is a Feature of Pancreatic Adenocarcinoma and Its Overexpression Is Associated With Poorer Survival. AM J PATHOL 2012;181 (5):1524-1529 [PubMed]
Vermeulen L, de Sousa E Melo F, Richel DJ, Medema JP, The developing cancer stem-cell model: clinical challenges and opportunities. LANCET ONCOL 2012;13 (2):E83-E89 [PubMed]
Wolkers MC, Gerlach C, Arens R, Janssen EM, Fitzgerald P, Schumacher TN, Medema JP, Green DR, Schoenberger SP, Nab2 regulates secondary CD8(+) T-cell responses through control of TRAIL expression. BLOOD 2012;119 (3):798-804 [PubMed]
Afonina IS, Tynan GA, Logue SE, Cullen SP, Bots M, Lüthi AU, Reeves EP, McElvaney NG, Medema JP, Lavelle EC, Martin SJ, Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α. MOL CELL 2011;44 (2):265-278 [PubMed]
Bakema JE, Ganzevles SH, Fluitsma DM, Schilham MW, Beelen RHJ, Valerius T, Lohse S, Glennie MJ, Medema JP, van Egmond M, Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy. J IMMUNOL 2011;187 (2):726-732 [PubMed]
Borovski T, de Sousa E Melo F, Vermeulen L, Medema JP, Cancer Stem Cell Niche: The Place to Be. CANCER RES 2011;71 (3):634-639 [PubMed]
de Sousa E Melo F, Colak S, Buikhuisen J, Koster J, Cameron K, de Jong JH, Tuynman JB, Prasetyanti PR, Fessler E, van den Bergh SP, Rodermond H, Dekker E, van der Loos CM, Pals ST, van de Vijver MJ, Versteeg R, Richel DJ, Vermeulen L, Medema JP, Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. CELL STEM CELL 2011;9 (5):476-485 [PubMed]
de Sousa E Melo F, Guessous I, Vermeulen L, Medema JP, Cellules souches cancéreuses et futures modalités thérapeutiques du cancer. REV MED SUISSE 2011;7 (289):774-777 [PubMed]
de Sousa E Melo F, Vermeulen L, Richel D, Medema JP, Targeting Wnt Signaling in Colon Cancer Stem Cells. CLIN CANCER RES 2011;17 (4):647-653 [PubMed]
Guadagnoli M, Kimberley F, Phan U, Cameron K, Vink P, Rodermond H, Eldering E, Kater A, van Eenennaam H, Medema JP, Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas. BLOOD 2011;117 (25):6856-6865 [PubMed]
Kimberley F, Guadagnoli M, van Eenennaam H, Medema JP, A Proliferation-Inducing Ligand (APRIL): The Development of Antagonistic Agents as Potential Therapeutics and Deciphering the Role of Heparan Sulphate Proteoglycans (HSPGs) in APRIL Signalling. ADV EXP MED BIOL 2011;691:501-506 [PubMed]
Lobito AA, Gabriel TL, Medema JP, Kimberley FC, Disease causing mutations in the TNF and TNFR superfamilies: Focus on molecular mechanisms driving disease. TRENDS MOL MED 2011;17 (9):494-505 [PubMed]
Medema JP, Vermeulen L, Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. NATURE 2011;474 (7351):318-326 [PubMed]
Müllauer FB. Betunic acid induced tumor killing. s.l.: s.n.; 2011. 155p. ISBN 9789461820006 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): Kessler JH)
Mullauer FB, van Bloois L, Daalhuisen JB, ten Brink MS, Storm G, Medema JP, Schiffelers RM, Kessler JH, Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity. ANTI-CANCER DRUG 2011;22 (3):223-233 [PubMed]
Reijmers RM, Groen RWJ, Kuil A, Weijer K, Kimberley FC, Medema JP, van Kuppevelt TH, Li JP, Spaargaren M, Pals ST, Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. BLOOD 2011;117 (23):6162-6171 [PubMed]
Bem RA, van Woensel JBM, Lutter R, Domachowske JB, Medema JP, Rosenberg HF, Bos AP, Granzyme A- and B-Cluster Deficiency Delays Acute Lung Injury in Pneumovirus-Infected Mice. J IMMUNOL 2010;184 (2):931-938 [PubMed]
de Bruijn MT, Raats DAE, Hoogwater FJH, van Houdt WJ, Cameron K, Medema JP, Borel Rinkes IHM, Kranenburg O, Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa. BRIT J CANCER 2010;102 (8):1254-1264 [PubMed]
Hoogwater FJH, Nijkamp MW, Smakman N, Steller EJA, Emmink BL, Westendorp BF, Raats DAE, Sprick MR, Schaefer U, van Houdt WJ, de Bruijn MT, Schackmann RCJ, Derksen PWB, Medema JP, Walczak H, Borel Rinkes IHM, Kranenburg O, Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells. GASTROENTEROLOGY 2010;138 (7):2357-2367 [PubMed]
Kemper K, Grandela C, Medema JP, Molecular identification and targeting of colorectal cancer stem cells. ONCOTARGET 2010;1 (6):387-395 [PubMed]
Kemper K, Sprick MR, de Bree M, Scopelliti A, Vermeulen L, Hoek M, Zeilstra J, Pals ST, Mehmet H, Stassi G, Medema JP, The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation. CANCER RES 2010;70 (2):719-729 [PubMed]
Kemper K, Tol MJPM, Medema JP, Mouse Tissues Express Multiple Splice Variants of Prominin-1. PLOS ONE 2010;5 (8):e12325 [PubMed]
Medema JP, Walczak H, Hahne M, de Laurenzi V, Cell death. CELL DEATH DIFFER 2010;17 (4):730-732
Mullauer FB, Kessler JH, Medema JP, Betulinic acid, a natural compound with potent anticancer effects. ANTI-CANCER DRUG 2010;21 (3):215-227 [PubMed]
Rodermond HM, ten Cate R, Haveman J, van Kuilenburg A, Medema JP, van Bree C, Franken NAP, Cyclopentenylcytosine does not enhance cisplatin-induced radiosensitization in human lung tumour cells. ONCOL LETT 2010;1 (3):537-540
Sottoriva A, Sloot PMA, Medema JP, Vermeulen L, Exploring cancer stem cell niche directed tumor growth. CELL CYCLE 2010;9 (8):1472-1479 [PubMed]
Sottoriva A, Verhoeff JJC, Borovski T, McWeeney SK, Naumov L, Medema JP, Sloot PMA, Vermeulen L, Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity. CANCER RES 2010;70 (1):46-56 [PubMed]
Todaro M, Francipane MG, Medema JP, Stassi G, Colon Cancer Stem Cells: Promise of Targeted Therapy. GASTROENTEROLOGY 2010;138 (6):2151-2162 [PubMed]
Vermeulen L. Cancer stem cells - a numbers game?. s.l.: s.n.; 2010. 224p. ISBN 9789090257105 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP, Richel DJ; copromotor(s): )
Vermeulen L, de Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP, Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. NAT CELL BIOL 2010;12 (5):468-U121 [PubMed]
Bergs JWJ, ten Cate R, Rodermond HM, Jaarsma PA, Medema JP, Darroudi F, Buist MR, Stalpers LJA, Haveman J, van Bree C, Franken NAP, Transient inhibition of Calyculin A induced premature chromosome condensation by hyperthermia. INT J HYPERTHER 2009;25 (3):220-228 [PubMed]
Borovski T, Verhoeff JJC, ten Cate R, Cameron K, de Vries NA, van Tellingen O, Richel DJ, van Furth WR, Medema JP, Sprick MR, Tumor microvasculature supports proliferation and expansion of glioma-propagating cells. INT J CANCER 2009;125 (5):1222-1230 [PubMed]
Borovski T, Vermeulen L, Sprick MR , Medema JP, One renegade cancer stem cell?. CELL CYCLE 2009;8 (6):803-808 [PubMed]
Cullen SP, Afonina IS, Donadini R, Lüthi AU, Medema JP, Bird PI, Martin SJ, Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing. J BIOL CHEM 2009;284 (8):5137-5147 [PubMed]
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, de Laurenzi V, de Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JHM, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G, Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. CELL DEATH DIFFER 2009;16 (8):1093-1107 [PubMed]
Kimberley FC, Hahne M, Medema JP, "APRIL hath put a spring of youth in everything": Relevance of APRIL for survival. J CELL PHYSIOL 2009;218 (1):1-8 [PubMed]
Kimberley FC, Medema JP, Hahne M, APRIL in B-cell malignancies and autoimmunity. RESULTS PROBL CELL DIFFER 2009;49:161-182 [PubMed]
Kimberley FC, van Bostelen L, Cameron K, Hardenberg G, Marquart JA, Hahne M, Medema JP, The proteoglycan (heparan sulfate proteoglycan) binding domain of APRIL serves as a platform for ligand multimerization and cross-linking. FASEB J 2009;23 (5):1584-1595 [PubMed]
Mullauer FB, Kessler JH, Medema JP, Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. APOPTOSIS 2009;14 (2):191-202 [PubMed]
Mullauer FB, Kessler JH, Medema JP, Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol. PLOS ONE 2009;4 (4):e1 [PubMed]
Vermeulen L, Medema JP, Hardwick JCH, van den Brink GR. Cancer Stem Cells in Colorectal Cancer in: Majumder S, editor. Stem Cells and Cancer. Berlin; New York: Springer; 2009., p. 233-250
Vermeulen L, Verhoeff JJC, Richel DJ, Medema JP, Kankerstamcellen. NED TIJDSCHR GENEESKD 2009;153 (7):286-290 [PubMed]
Bem RA, Bos AP, Bots M, Wolbink AM, van Ham SM, Medema JP, Lutter R, van Woensel JBM, Activation of the granzyme pathway in children with severe respiratory syncytial virus infection. PEDIATR RES 2008;63 (6):650-655 [PubMed]
Bergs JWJ, ten Cate R, Haveman J, Medema JP, Franken NAP, van Bree C, Chromosome Fragments have the Potential to Predict Hyperthermia-induced Radio-sensitization in Two Different Human Tumor Cell Lines. J RADIAT RES 2008;49 (5):465-472 [PubMed]
Bots M, Medema JP, Serpins in T cell immunity. J LEUKOCYTE BIOL 2008;84 (5):1238-1247 [PubMed]
de Bruin E. Apoptosis in cancer - regulation and prognostic value. S.l.: s.n.; 2008. 208p. ISBN 978-90-9022820-4 Proefschrift LUMC, Leiden, Klinische oncologie, onderzoek in AMC-UvA. (Promotor(s): Nortier JWR, van de Velde CJH, Medema JP; copromotor(s): Marijnen CAM)
de Bruin EC, Medema JP, Apoptosis and non-apoptotic deaths in cancer development and treatment response. CANCER TREAT REV 2008;34 (8):737-749 [PubMed]
de Bruin EC, van de Velde CJH, van Krieken JHJM, Marijnen CAM, Medema JP, Epithelial human leukocyte antigen-DR expression predicts reduced recurrence rates and prolonged survival in rectal cancer patients. CLIN CANCER RES 2008;14 (4):1073-1079 [PubMed]
Francipane MG, Alea MP, Lombardo Y, Todaro M, Medema JP, Stassi G, Crucial role of interleukin-4 in the survival of colon cancer stem cells. CANCER RES 2008;68 (11):4022-4025 [PubMed]
Hardenberg G. The role of APRIL in immunity and tumorigenicity. s.l.: s.n.; 2008. 191p. ISBN 9789064642418 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): )
Hardenberg G, Fernandez L, Hendriks J, Chebli K, Jacquet C, Sitbon M, Hahne M, Medema JP, APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis. J LEUKOCYTE BIOL 2008;84 (2):380-388 [PubMed]
Hardenberg G, van Bostelen L, Hahne M, Medema JP, Thymus-independent class switch recombination is affected by APRIL. IMMUNOL CELL BIOL 2008;86 (6):530-534 [PubMed]
Hardenberg G, van der Sluijs K, van der Poll T, Medema JP, APRIL affects antibody responses and early leukocyte infiltration, but not influenza A viral control. MOL IMMUNOL 2008;45 (11):3050-3058 [PubMed]
Planelles L, Medema JP, Hahne M, Hardenberg G, The Expanding Role of APRIL in Cancer and Immunity. CURR MOL MED 2008;8 (8):829-844 [PubMed]
Todaro M, Perez Alea M, Scopelliti A, Medema JP, Stassi G, IL-4-mediated drug resistance in colon cancer stem cells. CELL CYCLE 2008;7 (3):309-313 [PubMed]
van Bree C, Rodermond HM, Leen R, Medema JP, van Kuilenburg ABP, Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells. BRIT J CANCER 2008;98 (7):1226-1233 [PubMed]
van Bree C, Rodermond HM, ten Cate R, de Vos J, Stalpers LJA, Haveman J, Medema JP, Franken NAP, G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage. RADIAT RES 2008;170 (2):184-191 [PubMed]
Vermeulen L, Sprick MR , Kemper K, Stassi G, Medema JP, Cancer stem cells--old concepts, new insights. CELL DEATH DIFFER 2008;15 (6):947-958 [PubMed]
Vermeulen L, Todaro M, de Sousa E Melo F, Sprick MR , Kemper K, Alea MP, Richel DJ, Stassi G, Medema JP, Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. P NATL ACAD SCI USA 2008;105 (36):13427-13432 [PubMed]
Bergs JWJ, Haveman J, ten Cate R, Medema JP, Franken NAP, van Bree C, Effect of 41 degrees C and 43 degrees C on cisplatin radiosensitization in two human carcinoma cell lines with different sensitivities for cisplatin. ONCOL REP 2007;18 (1):219-226 [PubMed]
Bots M. The role of serine protease inhibitors in the modulation of anti-tumor immune responses. s.l.: s.n.; 2007. 148p. ISBN 9789064641107 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): )
Bots M, de Bruin E, Rademaker-Koot MTGA, Medema JP, Proteinase inhibitor-9 expression is induced by maturation in dendritic cells via p38 MAP kinase. HUM IMMUNOL 2007;68 (12):959-964 [PubMed]
de Bruin EC, van de Pas S, van de Velde CJH, van Krieken JHJM, Peltenburg LTC, Marijnen CAM, Medema JP, Gene expression profiling reveals two separate mechanisms regulating apoptosis in rectal carcinomas in vivo. APOPTOSIS 2007;12 (9):1671-1680 [PubMed]
Hardenberg G, Planelles L, Schwarte CM, van Bostelen L, Le Huong T, Hahne M, Medema JP, Specific TLR ligands regulate APRIL secretion by dendritic cells in a PKR-dependent manner. EUR J IMMUNOL 2007;37 (10):2900-2911 [PubMed]
Hulsman N, Medema JP, Bos C, Jongejan A, Leurs R, Smit MJ, de Esch IJP, Richel D, Wijtmans M, Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. J MED CHEM 2007;50 (10):2424-2431 [PubMed]
Kessler JH, Mullauer FB, de Roo GM, Medema JP, Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. CANCER LETT 2007;251 (1):132-145 [PubMed]
Planelles L, Castillo-Gutiérrez S, Medema JP, Morales-Luque A, Merle-Béral H, Hahne M, APRIL but not BLyS serum levels are increased in chronic lymphocytic leukemia: prognostic relevance of APRIL for survival. HAEMATOLOGICA 2007;92 (9):1284-1285 [PubMed]
Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, Iovino F, Tripodo C, Russo A, Gulotta G, Medema JP, Stassi G, Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. CELL STEM CELL 2007;1 (4):389-402 [PubMed]
Bots M, Medema JP, Granzymes at a glance. J CELL SCI 2006;119 (24):5011-5014 [PubMed]
Bots M, Offringa R, Medema JP, Does the serpin PI-9 protect tumor cells?. BLOOD 2006;107 (12):4974-5; author reply 4975 [PubMed]
Bots M, van Bostelen L, Rademaker MT, Offringa R, Medema JP, Serpins prevent granzyme-induced death in a species-specific manner. IMMUNOL CELL BIOL 2006;84 (1):79-86 [PubMed]
de Bruin EC, van de Velde CJH, van de Pas S, Nagtegaal ID, van Krieken JHJM, Gosens MJEM, Peltenburg LTC, Medema JP, Marijnen CAM, Prognostic value of apoptosis in rectal cancer patients of the dutch total mesorectal excision trial: radiotherapy is redundant in intrinsically high-apoptotic tumors. CLIN CANCER RES 2006;12 (21):6432-6436 [PubMed]
Griffioen M, Kessler JH, Borghi M, van Soest RA, van der Minne CE, Nouta J, van der Burg SH, Medema JP, Schrier PI, Falkenburg JHF, Osanto S, Melief CJM, Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy. CLIN CANCER RES 2006;12 (10):3130-3136 [PubMed]
van de Linde P, Tysma OMH, Medema JP, Hale G, Waldmann H, Roelen DL, Roep BO, Mechanisms of antibody immunotherapy on clonal islet reactive T cells. HUM IMMUNOL 2006;67 (4-5):264-273 [PubMed]
Bots M, Kolfschoten IGM, Bres SA, Rademaker MTGA, de Roo GM, Krüse M, Franken KLMC, Hahne M, Froelich CJ, Melief CJM, Offringa R, Medema JP, SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. BLOOD 2005;105 (3):1153-1161 [PubMed]
de Bruin EC, van de Pas S, Lips EH, van Eijk R, van der Zee MMC, Lombaerts M, van Wezel T, Marijnen CAM, van Krieken JHJM, Medema JP, van de Velde CJH, Eilers PHC, Peltenburg LTC, Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles. BMC GENOMICS 2005;6:142 [PubMed]
Hendriks J, Planelles L, de Jong-Odding J, Hardenberg G, Pals ST, Hahne M, Spaargaren M, Medema JP, Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation. CELL DEATH DIFFER 2005;12 (6):637-648 [PubMed]
Peltenburg LTC, de Bruin EC, Meersma D, Smit NPM, Schrier PI, Medema JP, Expression and function of the apoptosis effector Apaf-1 in melanoma. CELL DEATH DIFFER 2005;12 (6):678-679 [PubMed]
Edel MJ, Shvarts A, Medema JP, Bernards R, An in vivo functional genetic screen reveals a role for the TRK-T3 oncogene in tumor progression. ONCOGENE 2004;23 (29):4959-4965 [PubMed]
Planelles L, Carvalho-Pinto CE, Hardenberg G, Smaniotto S, Savino W, Gómez-Caro R, Alvarez-Mon M, de Jong J, Eldering E, Martínez-A C, Medema JP, Hahne M, APRIL promotes B-1 cell-associated neoplasm. CANCER CELL 2004;6 (4):399-408 [PubMed]
Vermijlen D, Luo D, Froelich CJ, Medema JP, Kummer JA, Willems E, Braet F, Wisse E, Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway. COMP HEPATOL 2004;3 (Suppl. 1):S58 [PubMed]
de Bruin EC, Meersma D, de Wilde J, den Otter I, Schipper EM, Medema JP, Peltenburg LTC, A serine protease is involved in the initiation of DNA damage-induced apoptosis. CELL DEATH DIFFER 2003;10 (10):1204-1212 [PubMed]
Kolfschoten GM, Pradet-Balade B, Hahne M, Medema JP, TWE-PRIL; a fusion protein of TWEAK and APRIL. BIOCHEM PHARMACOL 2003;66 (8):1427-1432 [PubMed]
Medema JP, Planelles-Carazo L, Hardenberg G, Hahne M, The uncertain glory of APRIL. CELL DEATH DIFFER 2003;10 (10):1121-1125 [PubMed]
Tolboom TCA, Medema JP, van Gaalen FA, Pieterman E, Huizinga TWJ, Toes REM, Fibroblast-like synoviocytes from rheumatoid arthritis patients express less FLICE-inhibitory protein than fibroblast-like synoviocytes from trauma patients: comment on the article by Schedel et al. ARTHRITIS RHEUM-US 2003;48 (3):858-9; author reply 859 [PubMed]
Velthuis JHL, de Bont HJGM, Medema JP, Kuppen PJK, Mulder GJ, Nagelkerke JF, Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells. IMMUNOBIOLOGY 2003;207 (2):115-127 [PubMed]
Medema JP, Medema RH, Chromosome instability: lessons from HIV. NAT CELL BIOL 2002;4 (8):E191-E193 [PubMed]
Medema JP, Simon AK, Suicide determines self. CELL DEATH DIFFER 2002;9 (4):364-366 [PubMed]
Pradet-Balade B, Medema JP, López-Fraga M, Lozano JC, Kolfschoten GM, Picard A, Martínez-A C, Garcia-Sanz JA, Hahne M, An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. EMBO J 2002;21 (21):5711-5720 [PubMed]
Stein JV, López-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodríguez D, Gómez-Caro R, de Jong J, Martínez-A C, Medema JP, Hahne M, APRIL modulates B and T cell immunity. J CLIN INVEST 2002;109 (12):1587-1598 [PubMed]
van Mierlo GJD, den Boer AT, Medema JP, van der Voort EIH, Fransen MF, Offringa R, Melief CJM, Toes REM, CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity. P NATL ACAD SCI USA 2002;99 (8):5561-5566 [PubMed]
Vermijlen D, Luo D, Froelich CJ, Medema JP, Kummer JA, Willems E, Braet F, Wisse E, Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J LEUKOCYTE BIOL 2002;72 (4):668-676 [PubMed]
Medema JP, de Jong J, Peltenburg LT, Verdegaal EM, Gorter A, Bres SA, Franken KL, Hahne M, Albar JP, Melief CJ, Offringa R, Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. P NATL ACAD SCI USA 2001;98 (20):11515-11520 [PubMed]
Medema JP, Schuurhuis DH, Rea D, van Tongeren J, de Jong J, Bres SA, Laban S, Toes RE, Toebes M, Schumacher TN, Bladergroen BA, Ossendorp F, Kummer JA, Melief CJ, Offringa R, Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells. J EXP MED 2001;194 (5):657-667 [PubMed]
Schurmans LR, Diehl L, den Boer AT, Sutmuller RP, Boonman ZF, Medema JP, van der Voort EI, Laman J, Melief CJ, Jager MJ, Toes RE, Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis. J IMMUNOL 2001;167 (10):5832-5837 [PubMed]
van Eijk M, Medema JP, de Groot C, Cutting edge: cellular Fas-associated death domain-like IL-1-converting enzyme-inhibitory protein protects germinal center B cells from apoptosis during germinal center reactions. J IMMUNOL 2001;166 (11):6473-6476 [PubMed]
van Elsas A, Sutmuller RP, Hurwitz AA, Ziskin J, Villasenor J, Medema JP, Overwijk WW, Restifo NP, Melief CJ, Offringa R, Allison JP, Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J EXP MED 2001;194 (4):481-489 [PubMed]
Melief CJ, Toes RE, Medema JP, van der Burg SH, Ossendorp F, Offringa R, Strategies for immunotherapy of cancer. ADV IMMUNOL 2000;75:235-282 [PubMed]
Medema JP, Apoptosis. Life and death in a FLASH. NATURE 1999;398 (6730):756-757 [PubMed]
Medema JP, Borst J, T cell signaling: a decision of life and death. HUM IMMUNOL 1999;60 (5):403-411 [PubMed]
Medema JP, de Jong J, van Hall T, Melief CJ, Offringa R, Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J EXP MED 1999;190 (7):1033-1038 [PubMed]
Medema JP, Hahne M, Walczak H, Laurenzi VD, The First European Workshop on Cell Death: (Death on the Rocks) held at Gran Sasso, Italy, 21 - 25 October 1998. Rocking cell death. CELL DEATH DIFFER 1999;6 (3):297-300 [PubMed]
Peter ME, Scaffidi C, Medema JP, Kischkel F, Krammer PH, The death receptors. RESULTS PROBL CELL DIFFER 1999;23:25-63 [PubMed]
Sark MW, Borgstein AM, Medema JP, van de Putte P, Backendorf C, Opposite effects of Ras or PKC activation on the expression of the SPRR2A keratinocyte terminal differentiation marker. EXP CELL RES 1999;250 (2):475-484 [PubMed]
de Laurenzi V, Hahne M, Walczak H, Medema JP, We aim to refresh science, not to rebel. NATURE 1998;393 (6682):206 [PubMed]
Medema JP, Scaffidi C, Krammer PH, Peter ME, Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex. J BIOL CHEM 1998;273 (6):3388-3393 [PubMed]
Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH, Peter ME, FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 1997;16 (10):2794-2804 [PubMed]
Medema JP, Toes RE, Scaffidi C, Zheng TS, Flavell RA, Melief CJ, Peter ME, Offringa R, Krammer PH, Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis. EUR J IMMUNOL 1997;27 (12):3492-3498 [PubMed]
Peter ME, Kischkel FC, Scheuerpflug CG, Medema JP, Debatin KM, Krammer PH, Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex. EUR J IMMUNOL 1997;27 (5):1207-1212 [PubMed]
Peter ME, Medema JP, Krammer PH, Does the Caenorhabditis elegans protein CED-4 contain a region of homology to the mammalian death effector domain?. CELL DEATH DIFFER 1997;4 (7):523-525 [PubMed]
Scaffidi C, Medema JP, Krammer PH, Peter ME, FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. J BIOL CHEM 1997;272 (43):26953-26958 [PubMed]
Medema JP, Pronk GJ, de Vries-Smits AM, Clark R, McCormick F, Bos JL, Insulin-induced tyrosine phosphorylation of a M(r) 70,000 protein revealed by association with the Src homology 2 (SH2) and SH3 domains of p120GAP and Grb2. CELL GROWTH DIFFER 1996;7 (4):543-550 [PubMed]
de Vries-Smits AM, Pronk GJ, Medema JP, Burgering BM, Bos JL, Shc associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS. ONCOGENE 1995;10 (5):919-925 [PubMed]
Medema JP, de Vries-Smits AM, Bos JL, Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa. ONCOGENE 1995;11 (4):757-762 [PubMed]
van Weering DH, Medema JP, van Puijenbroek A, Burgering BM, Baas PD, Bos JL, Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells. ONCOGENE 1995;11 (11):2207-2214 [PubMed]
Medema JP, Sark MW, Backendorf C, Bos JL, Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes. MOL CELL BIOL 1994;14 (11):7078-7085 [PubMed]
Medema JP, Streilein JW, Graser R, Vincek V, Nucleotide sequence of the tumor necrosis factor: a gene in seven different inbred mouse strains. IMMUNOGENETICS 1994;40 (3):243-244 [PubMed]
Streilein JW, Taylor JR, Vincek V, Kurimoto I, Richardson J, Tie C, Medema JP, Golomb C, Relationship between ultraviolet radiation-induced immunosuppression and carcinogenesis. J INVEST DERMATOL 1994;103 (5 Suppl):107S-111S [PubMed]
Burgering BM, Pronk GJ, Medema JP, van der Voorn L, de Vries Smits AM, van Weeren PC, Bos JL, Role of p21ras in growth factor signal transduction. BIOCHEM SOC T 1993;21 (4):888-894 [PubMed]
Vincek V, Kurimoto I, Medema JP, Prieto E, Streilein JW, Tumor necrosis factor alpha polymorphism correlates with deleterious effects of ultraviolet B light on cutaneous immunity. CANCER RES 1993;53 (4):728-732 [PubMed]
Key publications

de Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LPMH, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJM, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L, Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. NAT MED 2013;19 (5):614-618 [PubMed]
Medema JP, Vermeulen L, Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. NATURE 2011;474 (7351):318-326 [PubMed]
Medema JP, Cancer stem cells: the challenges ahead. NAT CELL BIOL 2013;15 (4):338-344 [PubMed]
Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, de Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S, The consensus molecular subtypes of colorectal cancer. NAT MED 2015;21 (11):1350-1356 [PubMed]
de Sousa E Melo F, Colak S, Buikhuisen J, Koster J, Cameron K, de Jong JH, Tuynman JB, Prasetyanti PR, Fessler E, van den Bergh SP, Rodermond H, Dekker E, van der Loos CM, Pals ST, van de Vijver MJ, Versteeg R, Richel DJ, Vermeulen L, Medema JP, Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. CELL STEM CELL 2011;9 (5):476-485 [PubMed]


All Publications

Curriculum Vitae

1986-1991 Study Chemistry, University of Leiden, The Netherlands.
Nov1991-Jan1996 Graduate Student at the Dept. of Physiological Chemistry, Utrecht University, Utrecht, The Netherlands.
Title of thesis: Calcium-induced inhibition of p21Ras: Involvement of p120GAP-associating proteins.
Promotor Prof. Dr. J.L. Bos.
Jun1995 Awarded a postdoctoral fellowship of the Dutch Cancer Society for a two year period
Jan1996 PhD degree
Apr1996-Sep1997 Dutch Cancer Society fellow at the dept. of Tumor Immunology, German Cancer Research Center, Heidelberg, Germany. (Head of the Department Prof. Dr. P.H. Krammer).
Sep1997-Mar1998 Dutch Cancer Society Fellow at dept. of Immunohematology and Bloodtransfusion, LUMC.
(Prof. Dr. C.J.M. Melief and Dr. R. Offringa).
Mar1998-April2000 Post Doctoral Fellow at the dept. of Immunohematology
and Bloodtransfusion, LUMC.
April2001-Sep2002 Assistant Professor (UD) at the dept. of Immunohematology
and Bloodtransfusion, LUMC.
Sep2002-Sep2004 Assistant Professor (UD), Head Research, dept of Clinical Oncology, LUMC.
Sep2004-July2005 Associate Professor (UHD), Head Research, Dept of Clinical Oncology LUMC.
Jun2005-now Head Laboratory for Experimental Oncology and Radiobiology (LEXOR), AMC.
Jan2006-now Professor Experimental Oncology and Radiobiology, UVA/AMC.
As of March 2011 Board member of AMC research council
Jan 2012-2015 Honorary Professor, Brunel University London, UK.
Jan 2012-2016 Deputy Head Center for Experimental Molecular Medicine, AMC

As of Jan 2016, Scientific co-director of the Alliance Research Intitute "Cancer Center Amsterdam"

As of Dec 2016, Department Head Center for Experimental Molecular Medicine, AMC

Research programmes

Cell death induction and resistance in tumor cells

Jan Paul Medema is scientific co-director of the Cancer Center of Amsterdam and professor in Experimental Oncology and Radiobiology. He is heading the Laboratory of EXperimental Oncology and Radiobiology (LEXOR) in the Academic Medical Center of the University of Amsterdam, The Netherlands. His laboratory consists of multiple independent research teams that focus on gastrointestinal cancer, including colorectal, pancreatic and esophageal cancer. The research lines headed by Jan Paul Medema all zoom in on a central theme, which is the mechanisms of cell death resistance of tumor cells against therapeutic interventions. The research lines roughly fall into three categories.

1. Colorectal Cancer stem cells. This specific subset of cancer cells has been shown by the LEXOR laboratory to be the driving force of cancers and to reconstitute a complete tumor upon xenotransplantation even when a single cell is used. Moreover, these cells possess a selective resistant to apoptosis induced by chemotherapy and are thus considered to initiate re-growth of the tumor upon therapy cessation. This research program is therefore directed at understanding the signals that maintain the Cancer Stem Cell properties of these cells and at defining their plasticity. Moreover, the aim is to define the mechanisms that underly the cell death resistance and identify therapies that can directly kill or sensitize cancer stem cells.

2. Colorectal cancer prognosis and response to therapy. LEXOR has, together with several international teams, shown that colon cancer patients can be divided into four subgroups, which have clearly distinct biological properties and follow a different clinical course. Of these the mesenchymal subgroup is shown to be associated with dismal prognosis and poor response to therapy. The research in the laboratory is therefore aimed at understanding the origin of the subtypes, the signals that are responsible for the maintenance of the specific biological programs and at identification of the vulnerabilities of the distinct subgroups. Combined with the development of diagnostic tools to identify these subtypes, this program therefore is directed at increasing the insight into the subtype and optimizing therapy for the individual patient.

3. Survival signaling by  the TNF family member APRIL. APRIL is a factor that is expressed in a wide range of tumor cells and appears to enhance their tumorigenicity by stimulating growth and pro-survival signaling. The LEXOR lab has invested strongly in the development of antagonistic tools to inhibit APRIL-induced pro-survival signaling and shown that these affect colorectal cancer growth. This program is currently aimed at understanding the mechanism behind this APRIL-induced survival and growth potentiation in colon cancer, with a final aim to develop the antagonistic tools for clinical use.

Faculty
Prof. dr. J.P. Medema
Dr. M.F. Bijlsma
Dr. N.A.P. Franken PhD
Prof. dr. L. Vermeulen MD PhD

Postdocs
S. van Hooff
Dr. D.J. Huels
Dr. N. Tuysuz

PhD Students
R.S.M. Adam
P.J. Asif
Drs. R.D. Blok
Drs. J.Y. Buikhuisen
Drs. E.A. Ebbing
Drs. M.C.S van der Heijden
S. ten Hoorn
A.B. Kirov
Drs. J.F. Linnekamp MD
S.C. Lodestijn
S.M. van Neerven MSc
P.R. Prasetyanti MD
P. Ramesh
Drs. A. Steins
C. Tekin
Drs. V.L. Veenstra
L. Zhang (NIN)
R. Klaassen MSc

Others
S.P. van den Bergh
G.G.W. van Bochove MSc
Ing. V. Bosch Lammers
K. Cameron
Ing. R. ten Cate
Ing. J. de Jong
Ing. H.M. Rodermond

Prof. dr. C.J.A. Punt MD PhD (Clinical and translational research in gastrointestinal cancer, with focus on colorectal cancer)

Other research related activities
  • Membership of editorial board / Editorship, CELL DEATH AND DIFFERENTIATION
  • Membership of advisory board / Consultant, Bionovion
  • Membership of advisory board / Consultant, AIRC 5/1000 program
  • Membership of editorial board / Editorship, ONCOGENESIS
  • Membership of medical or scientific committee, ERC (European Research Council), Consolidator Grants
  • Membership of medical or scientific committee, Other, program grants
  • Membership of medical or scientific committee, KWF Kankerbestrijding, Advisory Board Exploration
Current research funding
  • Aduro Biotech Europe B.V.
  • AMC
  • KWF Kankerbestrijding
  • Maag, Lever, Darm Stichting