• Principal Investigator
  • Female

Prof. dr. S. Middeldorp MD PhD

Position: Professor
Main activities: Research, Patient care
Specialisation: Vascular Medicine, research line of Thrombosis and Haemostasis
foto S. Middeldorp is one of the AMC Principal Investigators
Focus of research:

Etiology and treatment of venous thromboembolism

AMC themes: Cardiovascular Diseases
Departments: Internal Medicine: Vascular Medicine
Amraoui F. Vascular damage and dysfunction in hypertensive emergencies. S.l.: s.n.; 2017. 188p. ISBN 978-94-6233-530-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S, van der Post JM; copromotor(s): van den Born BJH, Vogt L)
Barco S, Atema JJ, Coppens M, Serlie MJ, Middeldorp S, Anticoagulants for the prevention and treatment of catheter-related thrombosis in adults and children on parenteral nutrition: a systematic review and critical appraisal. BLOOD TRANSFUS-ITALY 2017;15 (4):369-377 [PubMed]
Barco S, Picchi C, Trinchero A, Middeldorp S, Coppens M, Safety of prothrombin complex concentrate in healthy subjects. BRIT J HAEMATOL 2017;176 (4):664-666 [PubMed]
Beyer-Westendorf J, Lensing AWA, Arya R, Bounameaux H, Cohen AT, Wells PS, Middeldorp S, Verhamme P, Hughes R, Kucher N, Pap AF, Trajanovic M, Prins MH, Prandoni P, Weitz JI, Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials. THROMB RES 2017;149:29-37 [PubMed]
Bleker SM. Clinical aspects of venous thromboembolism in special patient populations. S.l.: s.n.; 2017. 297p. ISBN 978-94-6299-663-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S; copromotor(s): Büller HR, Di Nisio M)
Bleker SM, Brekelmans MPA, Eerenberg ES, Cohen AT, Middeldorp S, Raskob G, Büller HR, Clinical impact of major bleeding in patients with venous thrombo-embolism treated with factor Xa inhibitors or vitamin K antagonists. THROMB HAEMOSTASIS 2017;117 (10):1944-1951 [PubMed]
Brekelmans MPA, Ginkel Kv, Daams JG, Hutten BA, Middeldorp S, Coppens M, Benefits and harms of 4-factor prothrombin complex concentrate for reversal of vitamin K antagonist associated bleeding: a systematic review and meta-analysis. J THROMB THROMBOLYS 2017;44 (1):118-129 [PubMed]
Brekelmans MPA, Scheres LJJ, Bleker SM, Hutten BA, Timmermans A, Büller HR, Middeldorp S, Abnormal vaginal bleeding in women with venous thromboembolism treated with apixaban or warfarin. THROMB HAEMOSTASIS 2017;117 (4):809-815 [PubMed]
Cheung YW, Barco S, Mathôt RAA, van den Dool EJ, Stroobants AK, Serlie MJ, Middeldorp S, Coppens M, Pharmacokinetics of dabigatran etexilate and rivaroxaban in patients with short bowel syndrome requiring parenteral nutrition: The PDER PAN study. THROMB RES 2017;160:76-82 [PubMed]
Cohen H, Arachchillage DR, Middeldorp S, Beyer-Westendorf J, Abdul-Kadir R, Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH: reply. J THROMB HAEMOST 2017;15 (1):195-197 [PubMed]
Cunha MLR , Meijers JCM, Rosendaal FR, van Hylckama Vlieg A, Reitsma PH, Middeldorp S, Whole exome sequencing in thrombophilic pedigrees to identify genetic risk factors for venous thromboembolism. PLOS ONE 2017;12 (11):e0187699 [PubMed]
Groom KM, McCowan LM, Mackay LK, Lee AC, Said JM, Kane SC, Walker SP, van Mens TE, Hannan NJ, Tong S, Chamley LW, Stone PR, McLintock C [Contributors: Groom K, McCowan L, Mackay L, Lee A, Stone P, Chamley L, McLintock C, Said J, Kane S, Walker S, Tong S, Hannan N, van Mens T, Ganzevoort W, Middeldorp S]] , Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial. AM J OBSTET GYNECOL 2017;216 (3):296.e1-296.e14 [PubMed]
Horbach SER , Lokhorst MM, Oduber CEU, Middeldorp S, van der Post JAM, van der Horst CMAM, Complications of pregnancy and labour in women with Klippel-Trenaunay syndrome: a nationwide cross-sectional study. BJOG-INT J OBSTET GY 2017;124 (11):1780-1788 [PubMed]
Klaassen ILM, Lauw MN, van de Wetering MD, Biemond BJ, Middeldorp S, Abbink FCH, Bierings M, te Loo DMMW, Pieters R, van der Sluis IM, Tissing WJE, Zwaan CM, van Ommen CH, TropicALL study: Thromboprophylaxis in Children treated for Acute Lymphoblastic Leukemia with Low-molecular-weight heparin: a multicenter randomized controlled trial. BMC PEDIATR 2017;17:122 [PubMed]
Klok FA, Schreiber K, Stach K, Ageno W, Middeldorp S, Eichinger S, Delluc A, Blondon M, Ay C, Oral contraception and menstrual bleeding during treatment of venous thromboembolism: Expert opinion versus current practice Combined results of a systematic review, expert panel opinion and an international survey. THROMB RES 2017;153:101-107 [PubMed]
Middeldorp S, Iorio A, Oral contraceptive use is a provoking factor for venous thromboembolism. BMJ-BRIT MED J 2017;357:j2073 [PubMed]
Rodger MA, Gris JC, de Vries JIP, Martinelli I, Rey E, Schleussner E, Middeldorp S, Kaaja R, Langlois NJ, Ramsay T, Mallick R, Bates SM, Abheiden CNH, Perna A, Petroff D, de Jong P, van Hoorn ME, Bezemer PD, Mayhew AD, Low-Molecular-Weight Heparin and Recurrent Placenta-Mediated Pregnancy Complications: A Meta-analysis of Individual Patient Data From Randomised Controlled Trials. OBSTET GYNECOL SURV 2017;72 (3):153-155
Scheres LJJ, Brekelmans MPA, Beenen LFM, Büller HR, Cannegieter SC, Middeldorp S, Sex-specific differences in the presenting location of a first venous thromboembolism. J THROMB HAEMOST 2017;15 (7):1344-1350 [PubMed]
Schreiber K, Breen K, Cohen H, Jacobsen S, Middeldorp S, Pavord S, Regan L, Roccatello D, Robinson SE, Sciascia S, Seed PT, Watkins L, Hunt BJ, HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies. SEMIN THROMB HEMOST 2017;43 (6):562-571 [PubMed]
Silvis SM , Hiltunen S, Lindgren E, Jood K, Zuurbier SM, Middeldorp S, Putaala J, Cannegieter SC, Tatlisumak T, Coutinho JM, Cancer and risk of cerebral venous thrombosis: a case-control study. J THROMB HAEMOST 2017;ahead of print [PubMed]
van der Hulle T, Cheung WY, Kooij S, Beenen LFM , van Bemmel T, van Es J, Faber LM, Hazelaar GM, Heringhaus C, Hofstee H, Hovens MMC, Kaasjager KAH, van Klink RCJ, Kruip MJHA, Loeffen RF, Mairuhu ATA, Middeldorp S, Nijkeuter M, van der Pol LM, Schol-Gelok S, ten Wolde M, Klok FA, Huisman MV [Contributors: Fogteloo AJ, Kroft LJM, Brekelmans MP, Vermaire RMJ, Bastiaansen-Bergsma H, Biedermann JS, Klijn A, van der Voort S, Lieveld AWE, de Jong PY, Schaar CG, del Sol AI]] , Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study. LANCET 2017;390 (10091):289-297 [PubMed]
van der Pol LM, van der Hulle T, Cheung YW, Mairuhu ATA, Schaar CG, Faber LM, ten Wolde M, Hofstee HMA, Hovens MMC, Nijkeuter M, van Klink RCJ, Kruip MJHA, Middeldorp S, Huisman MV, Klok FA, No added value of the age-adjusted D-dimer cut-off to the YEARS algorithm in patients with suspected pulmonary embolism. J THROMB HAEMOST 2017;ahead of print [PubMed]
van Es N. Cancer and thrombosis: Improvements in strategies for prediction, diagnosis, and treatment. S.l.: s.n.; 2017. 297p. ISBN 978‐94‐6299‐749‐3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S, Bossuyt PMM; copromotor(s): Büller HR, Di Nisio M)
van Es N, Franke VF, Middeldorp S, Wilmink JW, Büller HR, The Khorana score for the prediction of venous thromboembolism in patients with pancreatic cancer. THROMB RES 2017;150:30-32 [PubMed]
van Mens TE, Joensen UN, Bochdanovits Z, Takizawa A, Peter J, Jørgensen N, Szecsi PB, Meijers JCM, Weiler H, Rajpert-de Meyts E, Repping S, Middeldorp S, Factor V Leiden is associated with increased sperm count. HUM REPROD 2017;32 (11):2332-2339 [PubMed]
van Mens TE, Meijers JCM, Middeldorp S, Circulating activated protein C in thrombophilia carriers. J THROMB THROMBOLYS 2017;43 (3):361-364 [PubMed]
van Mens TE, Scheres LJ, de Jong PG, Leeflang MM, Nijkeuter M, Middeldorp S, Imaging for the exclusion of pulmonary embolism in pregnancy. COCHRANE DB SYST REV 2017;2017 (1):CD011053 [PubMed]
Vlijm-Kievit A, Jorna NGE, Moll E, Pajkrt E, Pals ST, Middeldorp S, Biemond BJ, Zeerleder SS, Tio MA, Kemper EM, Hazenberg MD, Acute lymphoblastic leukemia during the third trimester of pregnancy. LEUKEMIA LYMPHOMA 2017;ahead of print [PubMed]
Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, Brighton TA, Cohen AT, Davidson BL, Decousus H, Freitas MCS, Holberg G, Kakkar AK, Haskell L, van Bellen B, Pap AF, Berkowitz SD, Verhamme P, Wells PS, Prandoni P [Contributors: Bianchi A, Brighton T, Carroll P, Chong B, Chunilal S, Coughlin P, Curnow J, Jackson D, Tran H, Ward C, Brodmann M, Kyrle P, Marschang P, Petkov V, Hainaut P, Jordens P, Vandekerkhof J, Verhamme P, Wautrecht JC, Annichino-Bizzacchi J, van Bellen B, Correa J, Cukier A, Freire A, Pereira A, Porto C, Sacilotto R, Vasconcelos Costa A, Della Siega A, Dolan S, Le Gal G2g, Gross P, Kahn S, Kassis J, Kovacs M, Pesant Y, Ritchie B, Schulman S, Shivakumar S, Solymoss S, Chang S, Chen R, Chen Z, Chen H, Dai X, Fang B, Fu W, Gao X, Huang J, Lai Y, Li L, Li X, Li Y, Liu J, Liu S, Ma W, Ni S, Qin Z, Shi G, Tian H, Wang S, Wang L, Xiao W, Ying K, Yu G, Yuan Y, Zhang J, Zhang J, Zhang X, Zhang L, Zhu L, Chlumský J, Chochola J, Dunaj M, Kovarova K, Lang P, Matoška P, Podpera I, Spacek R, Stehlikova O, Brønnum-Schou J, Egstrup K, Gislason G, Jeppesen J, May O, Nielsen H, Wiggers H, Achkar A, Aquilanti S, Benhamou Y, Brisot D, Bura-Riviere A, Castella N, Elias A, Falvo N, Ferrari E, Lacroix P, Mahe I, Meneveau N, Messas E, Mismetti P, Montaclair K, Mottier D, Moumneh T, Paleiron N, Parent F, Pernod G, Sanchez O, Schmidt J, Simoneau G, Stephan D, Amann B, Bauersachs R, Beyer-Westendorf J, Blessing E, Czihal M, Espinola-Klein C, Kahrmann G, Licka M, Neumeister A, Schellong S, Boda Z, Farkas K, Gurzo M, Katona A, Riba M, Sipos G, Tóth K, Braester A, Elias M, Gafter-Gvili A, Gavish D, Hussein O, Lishner M, Schiff E, Spectre G, Tzoran-Rozenthal I, Zimlichman R, Ageno W, Agnelli G, Bova C, Garbelotto R, Ghirarduzzi A, Imberti D, Pesavento R, Porreca E, Visonà A, Flota Cervera L, Llamas Esperón G, Rodriguez-Gonzalez D, Solis Morales L, Boersma W, ten Cate H, Erdkamp F, Grifioen-Keijzer A, Marwijk Kooy M, Meijer K, Middeldorp S, Swart-Heikens J, ten Wolde M, Westerweel P, Braithwaite I, Harper P, Merriman E, Ockelford P, Royle G, Smith M, Ghanima W, Sandset PM, Abola M, Chęciński P, Grzelakowski P, Lewczuk J, Sobkowicz B, Tomkowski W, Abramov I, Chechulov P, Karpenko A, Katelnitskiy I, Kazakov A, Makarova O, Panchenko E, Sergeeva E, Subbotin Y, Suchkov I, Zeltser M, Adler D, Breedt J, Fourie N, Isaacs R, Jacobson B, Siebert H, van Zyl L, Choi JH, Kang SM, Kim KH, Kim HS, Kim DI, Min SK, Park KH, García-Bragado Dalmau F, Gómez Cerezo J, Mirete JCF, Riera A, del Toro J, Eriksson H, Torstensson I, Banyai M, Baumgartner I, Mazzolai L, Periard D, Righini M, Staub D, Chiang CE, Chiu KM, Pai PY, Angchaisuksiri P, Chansung K, Öngen G, Tuncay E, Alikhan R, Chetter I, Kesteven P, Nokes T, Bauer K, Comerota A, Elias D, Garcia D, Gibson K, Ginsberg D, Jenkins J, Kingsley E, Lambert R, Lyons R, Pullman J, Shah V, Smith SW, Stein R, Tapson V, Walsh J, Wang TF, Do Loi D, Do Quang H, Pham N]] , Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism. NEW ENGL J MED 2017;376 (13):1211-1222 [PubMed]
Barco S. Thrombosis and anticoagulant treatment in special populations. S.l.: s.n.; 2016. 293p. ISBN 978-94-6182-657-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S; copromotor(s): Coppens M)
Barco S, Heuschen CBBCM, Salman B, Brekelmans MPA, Serlie MJ, Middeldorp S, Coppens M, Home parenteral nutrition-associated thromboembolic and bleeding events: results of a cohort study of 236 individuals. J THROMB HAEMOST 2016;14 (7):1364-1373 [PubMed]
Barco S, Whitney Cheung Y, Coppens M, Hutten BA, Meijers JCM, Middeldorp S, In vivo reversal of the anticoagulant effect of rivaroxaban with four-factor prothrombin complex concentrate. BRIT J HAEMATOL 2016;172 (2):255-261 [PubMed]
Bates SM, Middeldorp S, Rodger M, James AH, Greer I, Guidance for the treatment and prevention of obstetric-associated venous thromboembolism. J THROMB THROMBOLYS 2016;41 (1):92-128 [PubMed]
Beyer-Westendorf J, Michalski F, Tittl L, Middeldorp S, Cohen H, Abdul Kadir R, Arachchillage DJ, Arya R, Ay C, Marten S, Pregnancy outcome in patients exposed to direct oral anticoagulants - and the challenge of event reporting. THROMB HAEMOSTASIS 2016;116 (4):651-658 [PubMed]
Bleker SM, Buchmüller A, Chauleur C, Ní Áinle F, Donnelly J, Verhamme P, Jacobsen AF, Ganzevoort W, Prins M, Beyer-Westendorf J, DeSancho M, Konstantinides S, Pabinger I, Rodger M, Decousus H, Middeldorp S, Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses. THROMB RES 2016;144:62-68 [PubMed]
Bleker SM, Cohen AT, Büller HR, Agnelli G, Gallus AS, Raskob GE, Weitz JI, Curto M, Sisson M, Middeldorp S, Clinical presentation and course of bleeding events in patients with venous thromboembolism, treated with apixaban or enoxaparin and warfarin. Results from the AMPLIFY trial. THROMB HAEMOSTASIS 2016;116 (6):1159-1164 [PubMed]
Brekelmans MPA, Bleker SM, Bauersachs R, Boda Z, Büller HR, Choi Y, Gallus A, Grosso MA, Middeldorp S, Oh D, Raskob G, Schwocho L, Cohen AT, Clinical impact and course of major bleeding with edoxaban versus vitamin K antagonists. THROMB HAEMOSTASIS 2016;116 (1):155-161 [PubMed]
Cheung YW. Diagnosis, treatment and long-term effects of venous thromboembolism. S.l.: s.n.; 2016. 265p. ISBN 9789402803761 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S; copromotor(s): ten WM, Coppens M)
Cheung YW, Middeldorp S, Prins MH, Pap AF, Lensing AWA, ten Cate-Hoek AJ, Villalta S, Milan M, Beyer-Westendorf J, Verhamme P, Bauersachs RM, Prandoni P, Post-thrombotic syndrome in patients treated with rivaroxaban or enoxaparin/vitamin K antagonists for acute deep-vein thrombosis A post-hoc analysis. THROMB HAEMOSTASIS 2016;116 (4):733-738 [PubMed]
Cohen H, Arachchillage DRJ, Beyer-Westendorf J, Middeldorp S, Kadir RA, Direct Oral Anticoagulants and Women. SEMIN THROMB HEMOST 2016;42 (7):789-797 [PubMed]
Cohen H, Arachchillage DR, Middeldorp S, Beyer-Westendorf J, Abdul-Kadir R, Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH. J THROMB HAEMOST 2016;14 (8):1673-1676 [PubMed]
Connolly SJ, Milling TJ Jr, Eikelboom JW, Gibson CM, Curnutte JT, Gold A, Bronson MD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen AT, Beyer-Westendorf J, Albaladejo P, Lopez-Sendon J, Goodman S, Leeds J, Wiens BL, Siegal DM, Zotova E, Meeks B, Nakamya J, Lim WT, Crowther M [Contributors: Connolly SC, Crowther M, Eikelboom J, Gibson M, Milling TJ, Albaladejo P, Cohen A, Lopez-Sendon J, Middeldorp S, Schmidt J, Verhamme P, Beyer-Westendorf J, Wyse DG, Garcia D, Prins M, Nakamya J, Büller HR, Mahaffey K, Alexander J, Demchuk A, Raskob G, Schulman S, Meeks B, Zotova E, Holadyk-Gris I, Pinto T, Behr M, Lim T, Anand R, Bastani A, Caterino J, Clark C, Concha M, Cornell J, Eriksson E, Fermann G, Fulmer J, Goldstein J, Kereiakes D, Lotfipour S, Milling T, Moll S, Pallin D, Patel N, Refaai M, Rehman M, Schmaier A, Schwarz E, Shillinglaw W, Sinert R, Singer A, Takata T, Venkat A, Weinstein D, Welker J, Welsby I, Wiener S, Wilson J, Blostein M, van Keer L, Verschuren F, Coppens M, van Wissen S, Alikhan R, Breen K, Hall R]] , Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors. NEW ENGL J MED 2016;375 (12):1131-1141 [PubMed]
Heestermans M, Cunha MLR , Reitsma PH, Zeerleder SS, Middeldorp S, van Vlijmen BJM, Circulating nucleosomes and elastase α1-antitrypsin complexes and the novel thrombosis susceptibility locus SLC44A2. THROMB RES 2016;142:8-10 [PubMed]
Lim MY, Deal AM, Kim S, Musty MD, Conard J, Simioni P, Dutrillaux F, Eid SS, Middeldorp S, Halbmayer WM, Boneu B, Moia M, Moll S, Thrombophilic risk of individuals with rare compound factor V Leiden and prothrombin G20210A polymorphisms: an international case series of 100 individuals. EUR J HAEMATOL 2016;97 (4):353-360 [PubMed]
Lock J, de Bekker-Grob EW, Urhan G, Peters M, Meijer K, Brons P, van der Meer FJM, Driessens MHE, Collins PW, Fijnvandraat K, Leebeek FWG, Cnossen MH [Contributors: Cnossen MH, Leebeek FWG, Mathôt RAA, Kruip MH, de Wildt SN, Polinder S, de Bekker-Grob EW, Ista WG, Hazendonk HCAM, van Moort I, Steyerberg EW, Borsboom GJJM, Preijers T, Stokhuijzen E, Coppens M, Middeldorp S, Tamminga RYJ, Laros-van Gorkom BAP, van der Meer FJM, Eikenboom HCJ, Schutgens REG, Driessens MHE, de Meris J, Zwaan CM, Ramnarain S, Bosschaart-Castermans RMM, Rotte AE, Koolma A, Ammerlaan ACJ]] , Facilitating the implementation of pharmacokinetic-guided dosing of prophylaxis in haemophilia care by discrete choice experiment. HAEMOPHILIA 2016;22 (1):e1-e10 [PubMed]
Mahmoodi BK, Veeger NJGM, Middeldorp S, Lijfering WM, Brouwer JLP, ten Berg J, Hamulyák K, Meijer K, Interaction of Hereditary Thrombophilia and Traditional Cardiovascular Risk Factors on the Risk of Arterial Thromboembolism: Pooled Analysis of Four Family Cohort Studies. CIRC-CARDIOVASC GENE 2016;9 (1):79-85 [PubMed]
Martinelli I, Lensing AWA, Middeldorp S, Levi M, Beyer-Westendorf J, van Bellen B, Bounameaux H, Brighton TA, Cohen AT, Trajanovic M, Gebel M, Lam P, Wells PS, Prins MH, Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use. BLOOD 2016;127 (11):1417-1425 [PubMed]
McLintock C, Pabinger I, Bauer KA, Laffan M, Angchaisuksiri P, Rezende SM, Middeldorp S, Ross M, International Society on Thrombosis and Haemostasis core curriculum project: core competencies in clinical thrombosis and hemostasis. J THROMB HAEMOST 2016;14 (1):3-27 [PubMed]
Middeldorp S, Inherited thrombophilia: a double-edged sword. HEMATOL-AM SOC HEMAT 2016;2016 (1):1-9 [PubMed]
Rodger MA, Gris JC, de Vries JIP, Martinelli I, Rey É, Schleussner E, Middeldorp S, Kaaja R, Langlois NJ, Ramsay T, Mallick R, Bates SM, Abheiden CNH, Perna A, Petroff D, de Jong P, van Hoorn ME, Bezemer PD, Mayhew AD, Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials. LANCET 2016;388 (10060):2629-2641 [PubMed]
Scheres LJJ, Lijfering WM, Middeldorp S, Cannegieter SC, Influence of World Thrombosis Day on digital information seeking on venous thrombosis: a Google Trends study. J THROMB HAEMOST 2016;14 (12):2325-2328 [PubMed]
Sciascia S, Branch DW, Levy RA, Middeldorp S, Pavord S, Roccatello D, Ruiz-Irastorza G, Tincani A, Khamashta M, Schreiber K, Hunt BJ, The efficacy of hydroxychloroquine in altering pregnancy outcome in women with antiphospholipid antibodies. Evidence and clinical judgment. THROMB HAEMOSTASIS 2016;115 (2):285-290 [PubMed]
Silvis SM, Middeldorp S, Zuurbier SM, Cannegieter SC, Coutinho JM, Risk Factors for Cerebral Venous Thrombosis. SEMIN THROMB HEMOST 2016;42 (6):622-631 [PubMed]
van Vlijmen EFW, Veeger NJGM, Middeldorp S, Hamulyák K, Prins MH, Kluin-Nelemans HC, Meijer K, The impact of a male or female thrombotic family history on contraceptive counseling: a cohort study. J THROMB HAEMOST 2016;14 (9):1741-1748 [PubMed]
Zuurbier SM, Arnold M, Middeldorp S, Broeg-Morvay A, Silvis SM, Heldner MR, Meisterernst J, Nemeth B, Meulendijks ER, Stam J, Cannegieter SC, Coutinho JM, Risk of Cerebral Venous Thrombosis in Obese Women. JAMA NEUROL 2016;73 (5):579-584 [PubMed]
Zuurbier SM, Middeldorp S, Stam J, Coutinho JM, Sex differences in cerebral venous thrombosis: A systematic analysis of a shift over time. INT J STROKE 2016;11 (2):164-170 [PubMed]
Amraoui F, Hassani Lahsinoui H, Boussata S, Keijser R, Veenboer GJM, Middeldorp S, van der Post JAM, Ris-Stalpers C, Afink GB, van den Born BJH, Placental expression of heparan sulfate 3-O-sulfotransferase-3A1 in normotensive and pre-eclamptic pregnancies. PLACENTA 2015;36 (11):1218-1224 [PubMed]
Braamskamp MJAM, Stefanutti C, Langslet G, Drogari E, Wiegman A, Hounslow N, Kastelein JJP [Contributors: Kolovou G, Elisaf M, Middeldorp S, García Jiménez MC, Ponce EC, Di Giacomo S, Morozzi C, Pozzi C, Peretti N, Thompson G, McCrindle B, Guardamagna O]] , Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk. J PEDIATR-US 2015;167 (2):338-+ [PubMed]
Brekelmans M, Middeldorp S, Coppens M, Direct factor Xa inhibitor edoxaban: from bench to clinical practice. EXPERT REV HEMATOL 2015;8 (6):707-725 [PubMed]
Cheung YW, Barco S, Hutten BA, Meijers JCM, Middeldorp S, Coppens M, In vivo increase in thrombin generation by four-factor prothrombin complex concentrate in apixaban-treated healthy volunteers. J THROMB HAEMOST 2015;13 (10):1799-1805 [PubMed]
Coutinho JM, Zuurbier SM, Gaartman AE, Dikstaal AA, Stam J, Middeldorp S, Cannegieter SC, Association Between Anemia and Cerebral Venous Thrombosis: Case-Control Study. STROKE 2015;46 (10):2735-2740 [PubMed]
Cunha MLR , Bakhtiari K, Peter J, Marquart JA, Meijers JCM, Middeldorp S, A novel mutation in the F5 gene (factor V Amsterdam) associated with bleeding independent of factor V procoagulant function. BLOOD 2015;125 (11):1822-1825 [PubMed]
Cunha MLR , Meijers JCM, Middeldorp S, Introduction to the analysis of next generation sequencing data and its application to venous thromboembolism. THROMB HAEMOSTASIS 2015;114 (5):920-932 [PubMed]
de Boer AW, de Mutsert R, den Heijer M, Jukema JW, Rosendaal FR, Blom JW, Assendelft WJJ [Contributors: Middeldorp S, Rabelink TJ, Smit JWA, Romijn JA, Rabe KF, de Roos A, le Cessie S, Hiemstra PS, Kloppenburg M, Huizinga TWJ, Pijl H, Tamsma JT, de Koning EJP, Reitsma PH, van Dijk KW, de Vries APJ, Lamb HJ, Jazet IM, Dekkers OM, Biermasz NR, Cobbaert CM, Dekker JM, Penninx BW]] , Overweight can be used as a tool to guide case-finding for cardiovascular risk assessment. FAM PRACT 2015;32 (6):646-651 [PubMed]
de Crem N, Peerlinck K, Vanassche T, Vanheule K, Debaveye B, Middeldorp S, Verhamme P, Peetermans M, Abnormal uterine bleeding in VTE patients treated with rivaroxaban compared to vitamin K antagonists. THROMB RES 2015;136 (4):749-753 [PubMed]
de Jong PG. Inherited thrombophilia and pregnancy complications. S.l.: s.n.; 2015. 299p. ISBN 978-94-6259-711-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S; copromotor(s): Goddijn M)
de Jong PG, Hiddink L, Meijers JCM, Kiemeney LA, van Heerde WL, Middeldorp S, No association between Annexin A5 genetic variants and deep venous thrombosis. BRIT J HAEMATOL 2015;169 (2):301-304 [PubMed]
de Jong PG, Quenby S, Bloemenkamp KWM, Braams-Lisman BAM, de Bruin JP, Coomarasamy A, David M, DeSancho MT, van der Heijden OWH, Hoek A, Hutten BA, Jochmans K, Koks CAM, Kuchenbecker WKM, Mol BWJ, Torrance HL, Scheepers HCJ, Stephenson MD, Verhoeve HR, Visser J, de Vries JIP, Goddijn M, Middeldorp S, ALIFE2 study: low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia--study protocol for a randomized controlled trial. TRIALS 2015;16 (1):208 [PubMed]
Eerenberg ES, Middeldorp S, Levi M, Lensing AW, Büller HR, Clinical impact and course of major bleeding with rivaroxaban and vitamin K antagonists. J THROMB HAEMOST 2015;13 (9):1590-1596 [PubMed]
Klaassen ILM, van Ommen CH, Middeldorp S, Manifestations and clinical impact of pediatric inherited thrombophilia. BLOOD 2015;125 (7):1073-1077 [PubMed]
Lauw MN. Hypercoagulability in hematological malignancies. S.l.: s.n.; 2015. 293p. ISBN 978-94-6169-709-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S, van Oers MHJ; copromotor(s): Biemond BJ)
Middeldorp S, New studies of low-molecular-weight heparin in pregnancy. THROMB RES 2015;135 (Suppl. 1):S26-S29 [PubMed]
Middeldorp S, Tromboflebitis: onjuiste conclusies. HUISARTS WET 2015;58 (2):114-115
Middeldorp S, Hutten BA, Long-term vs Short-term Therapy With Vitamin K Antagonists for Symptomatic Venous Thromboembolism. JAMA-J AM MED ASSOC 2015;314 (1):72-73 [PubMed]
Schut AM, Venemans-Jellema A, Meijers JCM, Middeldorp S, de Groot PG, Rosendaal FR, Roest M, Lisman T, Cannegieter SC, Coagulation activation during air travel is not initiated via the extrinsic pathway. BRIT J HAEMATOL 2015;169 (6):903-905 [PubMed]
Thijs W, Janssen K, van Schadewijk AM, Papapoulos SE, le Cessie S, Middeldorp S, Melissant CF, Rabe KF, Hiemstra PS, Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment. PLOS ONE 2015;10 (11):e0140986 [PubMed]
van der Voort P, Pijls BG, Nieuwenhuijse MJ, Jasper J, Fiocco M, Plevier JWM, Middeldorp S, Valstar ER, Nelissen RGHH, Early subsidence of shape-closed hip arthroplasty stems is associated with late revision. A systematic review and meta-analysis of 24 RSA studies and 56 survival studies. ACTA ORTHOP 2015;86 (5):575-585 [PubMed]
van Es J, Beenen LFM, Douma RA, den Exter PL, Mos ICM, Kaasjager HAH, Huisman MV, Kamphuisen PW, Middeldorp S, Bossuyt PMM, A simple decision rule including D-dimer to reduce the need for computed tomography scanning in patients with suspected pulmonary embolism. J THROMB HAEMOST 2015;13 (8):1428-1435 [PubMed]
Zuurbier SM, Lauw MN, Coutinho JM, Majoie CBLM, van der Holt B, Cornelissen JJ, Middeldorp S, Biemond BJ, Stam J, Clinical Course of Cerebral Venous Thrombosis in Adult Acute Lymphoblastic Leukemia. J STROKE CEREBROVASC 2015;24 (7):1679-1684 [PubMed]
Akl EA, Kahale LA, Ballout RA, Barba M, Yosuico VED, van Doormaal FF, Middeldorp S, Bryant A, Schünemann H, Parenteral anticoagulation in ambulatory patients with cancer. COCHRANE DB SYST REV 2014;2014 (12):CD006652 [PubMed]
Barco S, Coppens M, van den Dool EJ, van de Kerkhof D, Stroobants AK, Middeldorp S, Successful co-administration of dabigatran etexilate and protease inhibitors ritonavir/lopinavir in a patient with atrial fibrillation. THROMB HAEMOSTASIS 2014;112 (4):836-838 [PubMed]
Bleker SM, Coppens M, Middeldorp S, Sex, thrombosis and inherited thrombophilia. BLOOD REV 2014;28 (3):123-133 [PubMed]
Coutinho JM, Middeldorp S, Stam J, Advances in the Treatment of Cerebral Venous Thrombosis. CURR TREAT OPTION NE 2014;16 (7):299 [PubMed]
de Jong PG, Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S, Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. COCHRANE DB SYST REV 2014;2014 (7):CD004734 [PubMed]
Di Nisio M, Middeldorp S, Treatment of Lower Extremity Superficial Thrombophlebitis. JAMA-J AM MED ASSOC 2014;311 (7):729-730 [PubMed]
Kaandorp SP, van Mens TE, Middeldorp S, Hutten BA, Hof MHP, van der Post JAM, van der Veen F, Goddijn M, Time to conception and time to live birth in women with unexplained recurrent miscarriage. HUM REPROD 2014;29 (6):1146-1152 [PubMed]
Kuipers S, Venemans A, Middeldorp S, Büller HR, Cannegieter SC, Rosendaal FR, The risk of venous thrombosis after air travel: contribution of clinical risk factors. BRIT J HAEMATOL 2014;165 (3):412-413 [PubMed]
Kuipers S, Venemans-Jellema A, Cannegieter SC, van Haften M, Middeldorp S, Büller HR, Rosendaal FR, The incidence of venous thromboembolism in commercial airline pilots: a cohort study of 2630 pilots. J THROMB HAEMOST 2014;12 (8):1260-1265 [PubMed]
Lee DH, Dane MJC, van den Berg BM, Boels MGS, van Teeffelen JW, de Mutsert R, den Heijer M, Rosendaal FR, van der Vlag J, van Zonneveld AJ, Vink H, Rabelink TJ [Contributors: Rosendaal FR, de Mutsert R, Middeldorp S, Rabelink TJ, Smit JWA, Romijn JA, Rabe KF, Jukema JW, de Roos A, le Cessie S, Hiemstra PS, Kloppenburg M, Huizinga TWJ, Pijl H, Tamsma JT, de Koning EJP, Assendelft PJJ, Reitsma PH, van Dijk KW, de Vries APJ, Lamb HJ, Jazet IM, Dekkers OM, Biermasz NR, Cobbaert CM, den Heijer M, Dekker JM, Penninx BW]] , Deeper Penetration of Erythrocytes into the Endothelial Glycocalyx Is Associated with Impaired Microvascular Perfusion. PLOS ONE 2014;9 (5):e96477 [PubMed]
Middeldorp S, Anticoagulation in pregnancy complications. HEMATOL-AM SOC HEMAT 2014;2014 (1):393-399 [PubMed]
Middeldorp S, Bleker SM, Women admitted to hospital during pregnancy have increased risk of venous thromboembolism that persists up to 28 days postdischarge. EVID BASED NURS 2014;17 (4):103 [PubMed]
Middeldorp S, Prins MH, Hutten BA, Duration of treatment with vitamin K antagonists in symptomatic venous thromboembolism. COCHRANE DB SYST REV 2014;2014 (8):CD001367 [PubMed]
Rodger MA, Langlois NJ, de Vries JI, Rey E, Gris JC, Martinelli I, Schleussner E, Ramsay T, Mallick R, Skidmore B, Middeldorp S, Bates S, Petroff D, Bezemer D, van Hoorn ME, Abheiden CN, Perna A, de Jong P, Kaaja R, Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM). SYST REV 2014;3 (1):69 [PubMed]
Sanders YV, Giezenaar MA, Laros-van Gorkom BAP, Meijer K, van der Bom JG, Cnossen MH, Nijziel MR, Ypma PF, Fijnvandraat K, Eikenboom J, Mauser-Bunschoten EP, Leebeek FWG [Contributors: Fijnvandraat K, Middeldorp S, Kors A, Zweegman S, de Meris J, Jonkers MH, Dors N, Nijziel MR, Meijer K, Tamminga RYJ, van der Linden PW, Gasthuis K, Ypma PF, van der Bom JG, Eikenboom HCJ, Smiers FJW, Granzen B, Hamuly K, Brons P, Laros-van Gorkom BAP, Leebeek FWG, Cnossen MH, Sanders YV, Mauser-Bunschoten EP]] , von Willebrand disease and aging: an evolving phenotype. J THROMB HAEMOST 2014;12 (7):1066-1075 [PubMed]
Thijs W, de Mutsert R, le Cessie S, Hiemstra PS, Rosendaal FR, Middeldorp S, Rabe KF, Reproducibility of exhaled nitric oxide measurements in overweight and obese adults. BMC RES NOTES 2014;7 (1):775 [PubMed]
van Es N, Coppens M, Schulman S, Middeldorp S, Büller HR, Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials. BLOOD 2014;124 (12):1968-1975 [PubMed]
van Es N, Sturk A, Middeldorp S, Nieuwland R, Effects of cancer on platelets. SEMIN ONCOL 2014;41 (3):311-318 [PubMed]
van Roessel S, Middeldorp S, Cheung YW, Zwinderman AH, de Pont ACJM, Accuracy of aPTT monitoring in critically ill patients treated with unfractionated heparin. NETH J MED 2014;72 (6):305-310 [PubMed]
Visser AW, de Mutsert R, Loef M, le Cessie S, den Heijer M, Bloem JL, Reijnierse M, Rosendaal FR, Kloppenburg M [Contributors: Rosendaal FR, de Mutsert R, Middeldorp S, Rabelink AJ, Smit JWA, Romijn JA, Rabe KF, Jukema JW, de Roos A, le Cessie S, Hiemstra PS, Kloppenburg M, Huizinga TWJ, Pijl H, Tamsma JT, de Koning EJP, Assendelft WJJ, Reitsma PH, van Dijk KW, de Vries APJ, Lamb HJ, Jazet IM, Dekkers OM, Biermasz NR, Cobbaert CM, den Heijer M, Dekker JM, Penninx BW]] , The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: the NEO study. OSTEOARTHR CARTILAGE 2014;22 (2):197-202 [PubMed]
Aarab R, van Es J, de Pont ACJM, Vroom MB, Middeldorp S, Monitoring of unfractionated heparin in critically ill patients. NETH J MED 2013;71 (9):466-471 [PubMed]
Barco S, Nijkeuter M, Middeldorp S, Pregnancy and venous thromboembolism. SEMIN THROMB HEMOST 2013;39 (5):549-558 [PubMed]
Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO, Recommendations for prophylaxis of pregnancy-related venous thromboembolism in carriers of inherited thrombophilia. Comment on the 2012 ACCP guidelines: a rebuttal. J THROMB HAEMOST 2013;11 (9):1782-1784 [PubMed]
Büller HR, Décousus H, Grosso MA, Mercuri M, Middeldorp S, Prins MH, Raskob GE, Schellong SM, Schwocho L, Segers A, Shi M, Verhamme P, Wells P [Contributors: Büller H, Agnelli G, Angchaisuksiri P, Banyai M, Bauersachs R, van Bellen B, Blüguermann J, Boda Z, Bounameaux H, Brenner B, Brighton T, Castañon JD, Chechulov P, Chlumský Y, Cohen A, Davidson B, Decousus H, Eriksson H, Gallus A, Gudz I, Jacobson B, Heng LL, Lyons R, Meijer K, Minar E, Monreal M, Nakamura M, Oh D, Öngen G, Parakh R, Piovella F, Raskob G, Rehm J, Sandset PM, Schellong S, Smith M, Sokurenko G, Tomkowski W, Torp-Pedersen C, Verhamme P, Wang C, Wang Y, Weitz J, Wells P, Yanushko V, Yin WH, Prins M, Beenen L , Brandjes D, MacGillavry M, Kaplowitz N, Otten HM, Pessayre D, Peters R, Roos Y, Slagboom T, Eikelboom J, Crowther M, Roberts R, Vanassche T, Vandenbriele C, Debaveye B, Segers A, Dani V, van Bergen P, Gerrits P, Mercuri M, van Kranen R, Lanz H, Grosso M, Schwocho L, Kappelhoff J, Franc J, Shi M, Zhang G, Lin M, Crerand W, Giordano C, Skinner M, Hurley S, Lovelace G, Barrier R, Betcher J, Alvarez C, Amuchastegui LM, Blüguermann J, Cassettari A, Ceressetto J, Hrabar N, Macin S, Mahuad C, Oberti P, Santini F, Baker RI, Blombery P, Brighton T, Carroll P, Chong B, Coughlin P, Crispin P, Fletcher J, Gallus A, Serisier DJ, Tran H, Chan N, Stafford L, Ward C, Baghestanian M, Kyrle PA, Eischer L, Traby L, Marschang P, Mathies R, Pilger E, Brodmann M, Roithinger F, Weltermann A, Adzerikho I, Davidovskaya E, Gorokhovsky S, Maslianski B, Kulik A, Yanushka A, de Vleeschauwer P, Debing E, Duchateau J, Gustin M, Hainaut P, Vandekerkhof J, Verhamme P, Peerlinck K, Verstraeten P, Wautrecht JC, Motte S, Annichino-Bizzacchi JM, Mello TBT, Menezes FH, Burihan M, Cavalcanti M, Correa J, Correa de Carvalho F, Cukier A, Manenti E, Manenti ER, Sacilotto R, Timi JM, van Bellen B, Kahn SR, Kovacs M, Langner AL, VanSpronsen H, Ritchie B, Shafai-Sarshar R, Shivakumar S, Anderson D, Robinson K, Gallant B, Wells P, Karovitch A, Scarvelis D, Carrier M, Bai CX, Chen RC, Cheng ZZ, Du YC, Hu XY, Gu YQ, Hao QL, Sun SB, Wang C, Jiang L, Liu CJ, Liu CW, Liu S, Wang XX, Ye XF, Ma Z, Qin ZQ, Qin XJ, Tian HY, Wang YQ, Shi ZY, Wen FQ, Wu Q, Yang YH, Kuang TG, Yang H, Ying KJ, Ma GF, Yuan YD, Yu J, Gong XW, Zhang FX, Zhang J, Zhang SX, Zhang JW, Zhang L, Zhao JC, Huang B, Zhao J, Chlumsky J, Hola D, Hirmerova J, Hutyra M, Klimsa Z, Holub M, Kovarova K, Lang P, Ryba M, Podoubský R, Matoska P, Mayer O, Patek F, Tupa M, Spacek R, Urbanova R, Blazejova S, Vitovec M, Andersen B, Brønnum-Schou J, Dominguez H, Egstrup K, Auscher S, Jeppesen J, Asferg C, Vishram J, Nielsen H, Galsgaard I, Michaelsen M, Haugaard-Nielsen B, Ostergaard O, Poulsen SH, Torp-Pedersen C, Masik S, Kadarik M, Meriste S, Paumets M, Laheäär M, Raidjuk L, Accassat S, Buchmuller A, Mismetti P, Achkar A, Aquilanti S, Rifaï A, Breuil N, Schmidt J, Brisot D, Brousse C, de la Fuentes PT, Chakra M, Crestani B, Desormais I, Lacroix P, Diamand JM, El Kouri D, Clairand R, Elias A, Ferrari E, Doyen D, Chiche O, Grange C, Guenneguez H, Lacut K, Couturaud F, Mottier D, Leroux L, Lorcerie B, de Maistre E, Berthier S, Mahe I, Martin M, Meneveau N, Meyer G, Sanchez O, Montaclair K, Pavic M, Pernod G, Imbert B, Quere I, Galanaud JP, Roy PM, Sevestre MA, Simoneau G, Stephan D, Aleil B, Mirea C, Trinh-Duc A, von Bilderling PB, Beyer-Westendorf J, Werth S, Köhler C, Halbritter K, Diehm C, Espinola-Klein C, Weisser G, Franke D, Heuer H, Horacek T, Kahrmann G, Kroening R, Lawall H, Roecken M, Schellong SM, Pomper L, Voigts B, Bernhard S, Frommhold R, Stellbrink C, Boda Z, Ilonczai P, Olah Z, Razso K, Schlammadinger A, Farkas K, Kolossváry E, Szabó I, Frankfurter Z, Gasztonyi B, Gurzó M, Klucsik Z, Kovacs A, Szigeti S, Varga C, Landi A, Nyirati G, Pecsvarady Z, Riba M, Sámson Z, Sipos G, Szigyártó M, Sebő N, Szabó TJ, Toth K, Agarwal S, Arneja J, Babhulkar S, Balaji R, Banker D, Bhagavan NK, Bhonagiri S, Mehta A, Dayasagar Rao V, Desai P, Desai SC, Chandrashekar AR, Singh R, Deshpande A, Dharmadhikari A, Durairaj N, Ghaisas N, Gupta S, Jain R, Jindal R, Kamerkar D, Kothiwale VA, Kothurkar A, Kulkarni R, Kumar S, Mody B, Nagabhushan KN, Pandharpurkar HK, Joshi S, Parakh R, Grover T, Patel J, Patel K, Dudhagra N, Pawar N, Penurkar M, Pinjala R, Rai K, Rao B, Raval M, Raval A, Mehta P, Ravi Kishore AG, Saravanan S, Shetty P, Srinivas A, Suresh KR, Sumanthraj K, Girija KR, Vinod MV, Gavish D, Ashkenazy B, Braester A, Caraco Y, Elias M, Goldstein L, Grossman E, Lahav M, Lishner M, Lugassy G, Oliven A, Rachmilevitz R, Tzoran I, Brenner B, Yeganeh S, Zeltser D, Zimlichman R, Ageno W, Barillari G, Pasca S, Bortoluzzi C, Cattaneo M, Falanga A, Ghirarduzzi A, Lodigiani C, Picchi C, Iosub DI, Porreca E, Prandoni P, Quintavalla R, Siragusa S, Akita T, Aoyama T, Fujimoto K, Hanzawa K, Ikeda U, Iwata H, Kobayashi T, Kondo K, Kurimoto T, Maeda H, Mo M, Munemasa M, Murakami H, Nishi Y, Nishibe T, Nishigami K, Nunohiro T, Obayashi T, Satoh T, Satokawa H, Shimizu K, Shiroma H, Sonoda M, Suzuki Y, Taniguchi S, Tsujita K, Yamada N, Yasuda C, Yoshida H, Chang HJ, Choi WI, Kwon KY, Rho BH, Choi JS, Hong YS, Joh JH, Kim DJ, Kim HS, Kim SH, Kim YK, Kim KU, Kim JY, Kwon TW, Lee TS, Lim SY, Mun YC, Oh DY, Park KH, Yun WS, Yoon HI, Diaz-Castañon J, Flota LF, Galindo J, Gomez Lara J, Jerjes-Sanchez C, Palomar-Lever A, Rodriguez D, Higareda I, Boersma WG, de Graaff CS, Oudeman L, Brans E, Bredie SJH, Dees A, Erdkamp F, Peters F, Fijnheer R, Gerdes VEA, Griffioen A, Jie KSG, Meijer K, Kooistra H, Wiewel-Verschueren S, Middeldorp S, Kamphuisen PW, van Es J, Eerenberg ES, Swart Heikens J, ten Cate H, ten Wolde M, Hes R, Atalay S, Harper P, Merriman E, Ockelford P, Hulton MH, Phillips J, Royle G, Ford A, Smith M, Ghanima W, Amundsen H, Sandset PM, Abola MT, Ganzon MS, Germar A, Checinski P, Kwasniewski A, Tomkowski W, Zechowicz T, Apartsin K, Arutyunov G, Barbarash O, Burov Y, Chechulov P, Varaksina E, Chernyatina M, Gladchenko M, Belikov L, Fokin A, Gubenko A, Igor K, Olga M, Kazakov Y, Kazakov A, Krasavin V, Linev K, Plechev V, Shesternya P, Shkurin V, Shvalb P, Sokurenko G, Sonkin I, Remizov A, Chernykh K, Staroverov I, Subbotin Y, Zeltser M, Seletsky A, Iliynykh A, Zilber A, Zubareva N, Tkachenko I, Pakhomova A, Raghuram J, Ng HJ, Sin K, Adler D, Weber F, van der Jagt R, Basson M, Becker J, Ellis G, Isaacs R, Jacobson B, Louw S, van Rensburg J, Siebert H, Skosana F, van Marle J, van Zyl L, le Roux R, Williams P, Cereto F, Garcia-Bragado F, Miranda RT, Carlsson A, Eriksson H, Villegas-Scivetti M, Ottosson E, Sjalander A, Torstensson I, Banyai M, Afarideh R, Gallino A, Mazzolai L, Righini M, Staub D, Chen CJ, Chiang CE, Wang KL, Chiu KM, Huang JH, Lai WT, Pai PY, Lin KH, Wang JH, Wu CC, Yin WH, Huang CL, Angchaisuksiri P, Kulpraneet M, Rojnuckarin P, Öngen G, Duman B, Ozkan S, Savas I, Selçuk T, Tuncay E, Gerasymov V, Gubka O, Gudz I, Voloshyn M, Nikulnikov P, Danylets A, Prasol V, Rusyn V, Sergeev O, Shtutin O, Skupyy O, Tatarin A, Venger I, Cohen AT, Patel R, Hunt BJ, Kesteven P, Robson L, MacCallum P, Nokes T, Rose P, Acs P, Gordan L, Bhatia A, Ali M, Amin D, Masson J, Gavi E, Ayele E, Ayeni O, Canosa R, Chavous D, Chen D, Comerota A, Concha M, Cunanan-Bush M, Daboul N, Daggubati S, Dang N, DiBella N, Driver A, Dulgeroff A, Fraiz J, Friedlander A, Galvez A, Jani C, Johnson S, Khandelwal P, Kingsley E, Kingsley J, Hutchinson L, Lavender R, Lyons R, Guzley G, Martinez R, Metjian A, Moran J, Nadar V, Pish R, Pullman J, Quaranta AJ, Ravi C, Refaai M, Rehm J, Richards D, Richwine R, Sachdeva S, Seibert A, Sharma A, Stricklin D, Tannenbaum A, Tin-U C, Vora K, Watkins D, Willms D]] , Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism. NEW ENGL J MED 2013;369 (15):1406-1415 [PubMed]
de Jong PG, Goddijn M, Middeldorp S, Antithrombotic therapy for pregnancy loss. HUM REPROD UPDATE 2013;19 (6):656-673 [PubMed]
de Mutsert R, den Heijer M, Rabelink TJ, Smit JWA, Romijn JA, Jukema JW, de Roos A, Cobbaert CM, Kloppenburg M, le Cessie S, Middeldorp S, Rosendaal FR, The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection. EUR J EPIDEMIOL 2013;28 (6):513-523 [PubMed]
Di Nisio M, Wichers IM, Middeldorp S, Treatment for superficial thrombophlebitis of the leg. COCHRANE DB SYST REV 2013;2013 (4):CD004982 [PubMed]
Gast KB, Smit JWA, den Heijer M, Middeldorp S, Rippe RCA, le Cessie S, de Koning EJP, Jukema JW, Rabelink TJ, de Roos A, Rosendaal FR, de Mutsert R [Contributors: Rosendaal FR, de Mutsert R, Middeldorp S, Rabelink TJ, Smit JWA, Romijn JA, Rabe KF, Jukema JW, de Roos A, le Cessie S, Hiemstra PS, Kloppenburg M, Huizinga TWJ, Pijl H, Tamsma JT, de Koning EJP, Assendelft WJJ, Reitsma PH, van Dijk KW, de Vries APJ, Lamb HJ, Jazet IM, Dekkers OM, Biermasz NR, Cobbaert CM, Heijer Md, Dekker JM, Penninx BW]] , Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study. ATHEROSCLEROSIS 2013;229 (2):423-429 [PubMed]
Goorhuis A, van Thiel PPAM, Middeldorp S, van Eck BLF, Grobusch MP, The tropics and the crime they did not commit. INFECTION 2013;41 (1):275-277 [PubMed]
Hillebrand S, Gast KB, de Mutsert R, Swenne CA, Jukema JW, Middeldorp S, Rosendaal FR, Dekkers OM, Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose-response meta-regression. EUROPACE 2013;15 (5):742-749 [PubMed]
Lauw MN, Barco S, Coutinho JM, Middeldorp S, Cerebral venous thrombosis and thrombophilia: a systematic review and meta-analysis. SEMIN THROMB HEMOST 2013;39 (8):913-927 [PubMed]
Lauw MN, van der Holt B, Middeldorp S, Meijers JCM, Cornelissen JJ, Biemond BJ, Venous thromboembolism in adults treated for acute lymphoblastic leukaemia: Effect of fresh frozen plasma supplementation. THROMB HAEMOSTASIS 2013;109 (4):633-642 [PubMed]
Lauw MN, van Doormaal FF, Middeldorp S, Buller HR, Cancer and venous thrombosis: current comprehensions and future perspectives. SEMIN THROMB HEMOST 2013;39 (5):507-514 [PubMed]
Middeldorp S, Thrombosis in women: what are the knowledge gaps in 2013?. J THROMB HAEMOST 2013;11 (Suppl. 1):180-191 [PubMed]
Romualdi E, Dentali F, Rancan E, Squizzato A, Steidl L, Middeldorp S, Ageno W, Anticoagulant therapy for venous thromboembolism during pregnancy: a systematic review and a meta-analysis of the literature. J THROMB HAEMOST 2013;11 (2):270-281 [PubMed]
Squizzato A, Romualdi E, Passamonti F, Middeldorp S, Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia. COCHRANE DB SYST REV 2013;2013 (4):CD006503 [PubMed]
van den Boogaard E, Cohn DM, Korevaar JC, Dawood F, Vissenberg R, Middeldorp S, Goddijn M, Farquharson RG, Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage. FERTIL STERIL 2013;99 (1):188-192 [PubMed]
van Es J. Adjustments in the diagnistic work-up, treatment and prognosis of pulmonary embolism. s.l.: s.n.; 2013. 238p. ISBN 9789461917409 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Middeldorp S, Kamphuisen PW; copromotor(s): Gerdes VEA, Douma RA)
van Es J, den Exter PL, Kaptein AA, Andela CD, Erkens PMG, Klok FA, Douma RA, Mos ICM, M Cohn D, Kamphuisen PW, Huisman MV, Middeldorp S, Quality of life after pulmonary embolism as assessed with SF-36 and PEmb-QoL. THROMB RES 2013;132 (5):500-505 [PubMed]
van Es J, Douma RA, Schreuder SM, Middeldorp S, Kamphuisen PW, Gerdes VEA, Beenen LFM, Clinical impact of findings supporting an alternative diagnosis on CT pulmonary angiography in patients with suspected pulmonary embolism. CHEST 2013;144 (6):1893-1899 [PubMed]
van Mens TE, Levi M, Middeldorp S, Evolution of Factor V Leiden. THROMB HAEMOSTASIS 2013;110 (1):23-30 [PubMed]
van Montfoort ML, Stephan F, Lauw MN, Hutten BA, van Mierlo GJ, Solati S, Middeldorp S, Meijers JCM, Zeerleder S, Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis. ARTERIOSCL THROM VAS 2013;33 (1):147-151 [PubMed]
Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO, VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. CHEST 2012;141 (2 Suppl):e691S-e736S [PubMed]
Bates SM, Greer IA, Middeldorp S, Veenstra D, Prabulos AM, Vandvik PO, Response. CHEST 2012;142 (2):545-546 [PubMed]
Büller HR, Gallus AS, Pillion G, Prins MH, Raskob GE [Contributors: Büller HR, Gallus AS, Prins MH, Raskob G, Decousus H, Charbonnier B, Leizorovicz A, Laporte S, Quenet S, Brandjes DPM, Middeldorp S, Blüguermann J, Amuchastegui L, Ahuad Guerrero R, Oberti P, Alvarez C, Cassettari A, Santos D, Macin S, Santini F, Ward C, Coughlin P, Salem H, Gan E, Leyden M, Prosser I, Crispin P, Carroll P, Gallus A, McRae S, Waites J, Pilger E, Koppensteiner R, Kyrle P, Schinko H, Mrochek A, Mitkovskaya N, Prystrom A, Motte S, Ninane V, Delcroix M, Hainaut P, Schneider E, Saraiva J, Maia L, Barreto S, Fernandes Manenti E, Araujo G, Dutra O, Fiss E, Moreira R, Yankov K, Nenkova S, Ivanov Y, Kostov V, Bhargava R, Chan Y, Miron MJ, Cusson J, Ugarte S, Morales A, Andresen M, Lanas F, Arriagada G, Mendoza JJ, Zuñiga C, Sepulveda P, Wang C, Liu Z, Yuan Y, Ma Z, Fang B, Liu J, Bai C, Wu H, Yang L, Ying K, Kang J, Li Q, Cheng Z, Zhang J, Wang H, Xie C, Xia G, Du Y, Wu Q, Zhou X, Chen L, Yi Q, Wu C, Hao Q, Liu S, Xiong S, Jiang S, Zhao L, Xiao Q, Qin Z, Zhou J, Dennis R, Miserque N, Igueredo M, Londoño D, Hildebrando J, Granados M, Buitrago R, Solano MH, Pacheco Alvis PM, Botero R, Saenz O, Bergovec M, Padovan M, Vucic N, Samarzija M, Chlumsky J, Spacek R, Klimsa Z, Gregor P, Povolny J, Podpera I, Holm F, Lang P, Matoska P, Sabl P, Spinar J, Spac J, Husted S, Avnstrom S, Rasmussen S, Christensen A, Guindy R, Hassanein M, Paumets M, Meriste S, Ferrari E, Achkar A, Azarian R, Meneveau N, Lorut C, Mouallem J, Crestani B, Proton A, Salmeron S, Lerousseau L, Mottier D, Wahl D, Siafakas N, Papadimitriou D, Katis K, Katsaris G, Gaga A, Damianos A, Tipparaju S, Kalkunte S, Vidhut J, Kalashetti S, Mehta P, Talwar D, Ramanathan R, Mishra R, Zeltzer D, Lahav M, Brenner B, Caraco Y, Elias M, Piovella F, Barone M, Poggio R, Palla A, Ghirarduzzi A, Pini M, Lodigiani C, Prandoni P, Agnelli G, Imberti D, Scannapieco G, Salvi A, Bautista E, Diaz J, Mercado R, Ranero A, Rodriguez D, Jerjes C, Villeda-Espinoza E, van der Meer J, Ijfering W, van Marwijk Kooy M, Boersma W, van Leendert R, Kroon C, Dullemond-Westland A, Viergever P, Kuipers A, Grootenboers M, Creemers J, Pieters W, de Munck D, Timmer H, Jackson S, Sandset P, Meyer P, Kristiansen T, Portugal J, Paz E, Salazar D, Chavez W, Castillo L, de Guia T, Lenora F, Tomkowski W, Kloczko J, Rybak Z, Gaciong Z, Sobkowicz B, Pruszczyk P, Nizankowski R, Mirek-Bryniarska E, Kukla P, Reis A, França A, Cortez M, Sa J, Santos F, Marques MA, Gordeev I, Gendlin G, Yablonsky P, Sokurenko G, Soroka V, Lusov V, Markov V, Shvats Y, Katerlnitskiy I, Lapin O, Lyamina N, Subbotin Y, Kim I, Zilber E, Kchaisheva L, Poliacik P, Macek V, Pretorius JP, Abdullah I, Basson M, Bollinger C, Breedt J, Gani M, Jansen J, Le Roux G, Nortje H, van der Linder M, van Zyl L, Viljoen J, Bruning A, Pujol Farriols R, Raguer E, Nuffal D, Sanchez Rodriguez A, Eriksson H, Almgren T, Carlsson A, Elf J, Olsson CG, Aagesen J, Savas I, Sahin A, Erdogan Y, Ozhan M, Ongen G, Celikel T, Turker H, Arseven O, Tuncay E, Ozacar R, Gudz I, Nykonenko O, Skupyy O, Kovalskyy I, Prasol V, Cohen A, Rodriguez-Cintron W, Gurka D, Bradley J, Oliver G, Spyropoulos A, Lerner R, Fulmer J, Lu NP, Wright P, Han D, Servi R, Nadar V, Quaranta A, Gehring J, Ginsberg R, Jacobson A, Colan D, Vanway C, Gurza E, Braslow B, Shorr A, Rehm J, Martin J, Sellers M, Concha M, Gordon I, Pullman J, Moran J, Welker J, Panzarella P, Mullins M, Willms D, McGrew F, Turki M, Menajovsky L]] , Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised, double-blind, double-dummy, non-inferiority trial. LANCET 2012;379 (9811):123-129 [PubMed]
Cohn DM, Vansenne F, de Borgie CA, Middeldorp S, Thrombophilia testing for prevention of recurrent venous thromboembolism. COCHRANE DB SYST REV 2012;2012 (12):CD007069 [PubMed]
de Jong PG, Coppens M, Middeldorp S, Duration of anticoagulant therapy for venous thromboembolism: balancing benefits and harms on the long term. BRIT J HAEMATOL 2012;158 (4):433-441 [PubMed]
Dentali F, Ageno W, Rezoagli E, Rancan E, Squizzato A, Middeldorp S, Margaglione M, Grandone E, Low-dose aspirin for in vitro fertilization or intracytoplasmic sperm injection: a systematic review and a meta-analysis of the literature. J THROMB HAEMOST 2012;10 (10):2075-2085 [PubMed]
Di Nisio M, Wichers IM, Middeldorp S, Treatment for superficial thrombophlebitis of the leg. COCHRANE DB SYST REV 2012;2012 (3):CD004982 [PubMed]
Lauw MN, Bus EWN, van Wulfften Palthe AFY, Coppens M, Homburg CH, Middeldorp S, van der Schoot CE, Koene HR, Biemond BJ, Relevance of the JAK2V617F mutation in patients with deep vein thrombosis of the leg. ANN HEMATOL 2012;91 (1):103-107 [PubMed]
Lussana F, Coppens M, Cattaneo M, Middeldorp S, Pregnancy-related venous thromboembolism: Risk and the effect of thromboprophylaxis. THROMB RES 2012;129 (6):673-680 [PubMed]
Lussana F, de Rooij SR, Veenendaal M, Razzari C, Fontana G, Faioni EM, Painter RC, Middeldorp S, Cattaneo M, Roseboom TJ, Prevalence of factor V Leiden and G20210A prothrombin mutation in the Dutch Famine Birth Cohort: A possible survival advantage?. THROMB HAEMOSTASIS 2012;108 (2):399-401 [PubMed]
Pijls BG, Nieuwenhuijse MJ, Fiocco M, Plevier JW, Middeldorp S, Nelissen RG, Valstar ER, Early proximal migration of cups is associated with late revision in THA A systematic review and meta-analysis of 26 RSA studies and 49 survival studies. ACTA ORTHOP 2012;83 (6):583-591 [PubMed]
Pijls BG, Nieuwenhuijse MJ, Schoones JW, Middeldorp S, Valstar ER, Nelissen RGHH, RSA prediction of high failure rate for the uncoated Interax TKA confirmed by meta-analysis. ACTA ORTHOP 2012;83 (2):142-147 [PubMed]
Pijls BG, Valstar ER, Nouta KA, Plevier JW, Fiocco M, Middeldorp S, Nelissen RG, Early migration of tibial components is associated with late revision A systematic review and meta-analysis of 21,000 knee arthroplasties. ACTA ORTHOP 2012;83 (6):614-624 [PubMed]
Reitsma PH, Versteeg HH, Middeldorp S, Mechanistic View of Risk Factors for Venous Thromboembolism. ARTERIOSCL THROM VAS 2012;32 (3):563-568 [PubMed]
Roshani S. Venous and arterial thrombosis : associations and risk factors. S.l.: s.n.; 2012. 187p. Proefschrift Rijksuniversiteit Leiden, Faculteit Geneeskunde. (Promotor(s): Middeldorp S, Reitsma PH; copromotor(s): )
van Es J, Beenen LFM, Gerdes VEA, Middeldorp S, Douma RA, Bossuyt PMM, The accuracy of D-dimer testing in suspected pulmonary embolism varies with the Wells score. J THROMB HAEMOST 2012;10 (12):2630-2632 [PubMed]
Akl EA, Gunukula S, Barba M, Yosuico VED, van Doormaal FF, Kuipers S, Middeldorp S, Dickinson HO, Bryant A, Schünemann H, Parenteral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation. COCHRANE DB SYST REV 2011;2011 (4):CD006652 [PubMed]
Akl EA, Gunukula S, Barba M, Yosuico VED, van Doormaal FF, Kuipers S, Middeldorp S, Dickinson HO, Bryant A, Schünemann H, Parenteral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation. COCHRANE DB SYST REV 2011;2011 (1):CD006652 [PubMed]
de Jong PG, Goddijn M, Middeldorp S, Testing for inherited thrombophilia in recurrent miscarriage. SEMIN REPROD MED 2011;29 (6):540-547 [PubMed]
Douketis JD, Julian JA, Crowther MA, Kearon C, Bates SM, Barone M, Piovella F, Middeldorp S, Prandoni P, Johnston M, Costantini L, Ginsberg JS, The effect of prothrombotic blood abnormalities on risk of deep vein thrombosis in users of hormone replacement therapy: a prospective case-control study. CLIN APPL THROMB-HEM 2011;17 (6):E106-E113 [PubMed]
Heleen van Ommen C, Middeldorp S, Thrombophilia in childhood: to test or not to test. SEMIN THROMB HEMOST 2011;37 (7):794-801 [PubMed]
Kaandorp SP. Unexplained recurrent miscarriage. s.l.: s.n.; 2011. 127p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van der Veen F, Middeldorp S; copromotor(s): Goddijn M, van der Post JAM)
Middeldorp S, Duration of anticoagulation for venous thromboembolism. BMJ-BRIT MED J 2011;342:d2758 [PubMed]
Middeldorp S, Evidence-based approach to thrombophilia testing. J THROMB THROMBOLYS 2011;31 (3):275-281 [PubMed]
Middeldorp S, How I treat pregnancy-related venous thromboembolism. BLOOD 2011;118 (20):5394-5400 [PubMed]
Middeldorp S, Is thrombophilia testing useful?. HEMATOL-AM SOC HEMAT 2011;2011:150-155 [PubMed]
Middeldorp S, Low-molecular-weight heparins have no place in recurrent miscarriage: Debate - For the motion. THROMB RES 2011;127 (Suppl. 3):S105-S109 [PubMed]
Pijls BG, Dekkers OM, Middeldorp S, Valstar ER, van der Heide HJL, van der Linden-van der Zwaag HMJ, Nelissen RGHH, AQUILA: assessment of quality in lower limb arthroplasty. An expert Delphi consensus for total knee and total hip arthroplasty. BMC MUSCULOSKEL DIS 2011;12 (1):173 [PubMed]
Pintao MC, Roshani S, de Visser MCH, Tieken C, Tanck MWT, Wichers IM, Meijers JCM, Rosendaal FR, Middeldorp S, Reitsma PH, High levels of protein C are determined by PROCR haplotype 3. J THROMB HAEMOST 2011;9 (5):969-976 [PubMed]
Roach REJ, Roshani S, Meijer K, Hamulyák K, Lijfering WM, Prins MH, Büller HR, Middeldorp S, Risk of cardiovascular disease in double heterozygous carriers and homozygous carriers of F5 R506Q (factor V Leiden) and F2 (prothrombin) G20210A: a retrospective family cohort study. BRIT J HAEMATOL 2011;153 (1):134-136 [PubMed]
Roeters van Lennep JE, Meijer E, Klumper FJCM, Middeldorp JM, Bloemenkamp KWM, Middeldorp S, Low-molecular-weight-heparin and pregnancy, when the dose does it: a nephrologist's opinion: reply to a rebuttal. J THROMB HAEMOST 2011;9 (10):2129-2130 [PubMed]
Roeters van Lennep JE, Meijer E, Klumper FJCM, Middeldorp JM, Bloemenkamp KWM, Middeldorp S, Prophylaxis with low-dose low-molecular-weight heparin during pregnancy and postpartum: is it effective?. J THROMB HAEMOST 2011;9 (3):473-480 [PubMed]
Roeters van Lennep JE, Meijer E, Klumper FJCM, Middeldorp JM, Bloemenkamp KWM, Middeldorp S, Prophylaxis with low-dose low molecular weight heparin during pregnancy and the puerperium: is it effective? Reply to a rebuttal. J THROMB HAEMOST 2011;9 (6):1272-1273 [PubMed]
Roshani S, Cohn DM, Stehouwer AC, Wolf H, van der Post JAM, Büller HR, Kamphuisen PW, Middeldorp S, Incidence of postpartum haemorrhage in women receiving therapeutic doses of low-molecular-weight heparin: results of a retrospective cohort study. BMJ OPEN 2011;1 (2):e000257 [PubMed]
Roshani S, Lijfering WM, Coppens M, Hamulyák K, Prins MH, Büller HR, Middeldorp S, Risk factors of arterial cardiovascular complications in patients with prior venous thromboembolism. NETH J MED 2011;69 (1):27-30 [PubMed]
Squizzato A, Keller T, Romualdi E, Middeldorp S, Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease. COCHRANE DB SYST REV 2011;2011 (1):CD005158 [PubMed]
Tanck MWT, Wichers IM, Meijers JCM, Büller HR, Reitsma PH, Middeldorp S, Quantitative trait locus for protein C in a family with thrombophilia. THROMB HAEMOSTASIS 2011;105 (1):199-201 [PubMed]
van Vlijmen EFW, Veeger NJGM, Middeldorp S, Hamulyák K, Prins MH, Büller HR, Meijer K, Thrombotic risk during oral contraceptive use and pregnancy in women with factor V Leiden or prothrombin mutation: a rational approach to contraception. BLOOD 2011;118 (8):2055-61; quiz 2375 [PubMed]
[Contributors: Büller HR, Destors JM, Gallus A, Prins MH, Raskob G, Charbonnier B, Decousus H, Leizorovicz A, Laporte S, Brandjes DPMB, Middeldorp S, Pillion G, Ceresetto JM, Hendler H, Xavier DL, Santini F, del Carmen Gallo M, Coughlin P, Chong B, Leahy M, Ward C, Leyden M, Prosser I, Carroll P, Gan E, McRae S, Salem H, Pilger E, Koppensteiner R, Jurecka W, Forstner K, Hainaut P, Motte S, Vermassen F, Araujo GR, Timi JRR, Costa JA, Manenti F, Yoshida WB, Kovacs M, Delle Siega A, Rodger M, Miron MJ, Anderson D, Yeo E, Kassis J, Spacek R, Klimsa Z, Patek F, Matoska P, Maly J, Srnsky V, Cepelak C, Nielsen H, Noelsen HK, Avstrom S, Husted S, Tuxen C, Stender S, Azarian R, Leftheriotis G, Jego P, Achkar A, Zeltser D, Keidar S, Inbal A, Piovella F, Barone M, Prandoni P, Imberti D, Palaretti G, Jerjes C, Calvo C, van Marwijk Kooij M, Timmerman R, Mol J, ten Cate H, Kamphuisen P, Dullemond A, Kroon C, Veth D, Biesma D, van Leendert R, Ockelford P, Chunilal S, Szyber P, Strzelczyk J, Checinsli P, Nizankowki R, Cianciara J, Kloczko J, Tomkowski W, Gutowski P, Stupin V, Sokurenko G, Kirienko A, Baesukov A, Sokora V, Katelnitsky I, Didenko Y, Lukianov Y, Zatevakhin I, Gavrilenko A, van Zyl LJ, Basson MMD, Becker LHR, Siebert S, Engelbrecht JM, Otero DR, Paloma MJ, del Toro H, Kürşat Bozkurt A, Joseph S, Nadar V, Baird I, Han D, Jacobson A, Martin J, Smith D, Comerota A, Guza E, Wright P]] , Efficacy and safety of once weekly subcutaneous idrabiotaparinux in the treatment of patients with symptomatic deep venous thrombosis. J THROMB HAEMOST 2011;9 (1):92-99 [PubMed]
Cohn DM. Thrombophilia ad dies vitae. s.l.: s.n.; 2010. 184p. ISBN 9789090250052 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Büller HR; copromotor(s): Middeldorp S, Kamphuisen PW)
Cohn DM, Goddijn M, Middeldorp S, Korevaar JC, Dawood F, Farquharson RG, Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy. J THROMB HAEMOST 2010;8 (10):2208-2213 [PubMed]
Cohn DM, Repping S, Büller HR, Meijers JCM, Middeldorp S, Increased sperm count may account for high population frequency of factor V Leiden. J THROMB HAEMOST 2010;8 (3):513-516 [PubMed]
Decousus H, Prandoni P, Mismetti P, Bauersachs RM, Boda Z, Brenner B, Laporte S, Matyas L, Middeldorp S, Sokurenko G, Leizorovicz A [Contributors: Décousus H, Leizorovicz A, Bauersachs R, Brenner B, Laporte S, Middeldorp S, Mismetti P, Prandoni P, Richard-Lordereau I, Boda Z, Matyas L, Sokurenko G, Schulman S, Cucherat M, Ford I, Monreal M, Becker F, Bost V, Girard P, Constans J, Gauthier E, Seymour L, Froloshki B, Stober P, Borthwick L, Jaques D, Trelfa A, Allende-Echevarrietta P, Kensit S, Kovacs I, Laursen E, Dramov A, Chlumsky J, Maasalu K, Quere I, Kiskinis D, Hoffman R, Piovella F, Krievins D, Oszkinis G, Stvrtinova V, Lozano Sanchez F, Mazzolai L, Myschalov V, Popovich V, Baluev M, Burov Y, Mikulskaya E, Chirkova V, Shvalb P, Kalinin R, Kachinskiy A, Apartsin K, Shulikovskaya I, Chizhova E, Subbotin Y, Shulgina L, Ignatenko P, Antropova N, Solomatin A, Nosko V, Zhukov B, Melnikov M, Zubareva N, Gusev V, Mineev D, Plechev V, Oleynik B, Khafizov A, Barbarash O, Lonchakova I, Berns S, Dubrovskiy A, Mikhaylov D, Mosin S, Chumakov A, Smirnov G, Krasavin V, Suplotova L, Ivanov E, Klushina T, Chernyatina M, Belikov L, Gladchenko M, Khmelniker S, Peshkov A, Shanigin A, Voskanyan Y, Golubov E, Shnukov R, Esipenko V, Neverko I, Ivanov A, Lenskaya L, Hvashevskiy A, Kotelnikov M, Apurin S, Zonova E, Nimaev V, Rogalev K, Butorin S, Sabelnikov V, Prokopets A, Nikiforov Y, Chernyakov A, Kon E, Guskova A, Katelnitskiy I, Belentsov S, Rodoman G, Ershova O, Soroka V, Mátyás L, Szentesi S, Simon G, Hajdu L, Varga M, Mogán I, Darabos G, Simó G, Ungár D, Bende B, Nyíri B, Rázsó K, Oláh Z, Halmos F, Gergely M, Somogyi Z, Kollár L, Menyhei G, Benkö L, Szentpéteri I, Simon J, Szegedi J, Murányi A, Frank J, Schoenen B, Grossgloss T, Mueller-Buehl U, Eggeling T, Eggeling S, Mietaschk A, von Bilderling P, Kurzbach J, Pfister R, Buechner L, Schoen N, Schoen B, Kaehler W, Schnieder HG, Enderle J, Muenter KC, Schulte-Huermann D, Ruetten A, Ante D, von Nettelbladt EF, Zollman C, Kamphausen U, Keilhau DA, Brado B, Pourhassan S, Boss S, Noppeney T, Betzl G, Herman G, Tsantilas D, Gudz I, Voloshyna M, Syerna A, Nikulnikov P, Danylets A, Guch A, Skupyy O, Tatarin A, Kravchenko I, Shtutin O, Rodin Y, Konovalova K, Sergeev O, Socolov A, Harbarlak S, Mylytsya M, Mylytsya K, Grigorjeva M, Shershneva O, Myshalov V, Chernyak V, Nykonenko O, Velygotskyy M, Bobrov O, Sofronkov N, Feshchenko Y, Kobza I, Rusyn V, Guenneguez H, Ouvry P, Di Maio A, Diamand JM, Quéré I, Brisot D, Martin M, Bressollette L, Louis P, Boveda S, Delsart D, Faisse P, Elias A, Aquilanti S, Gris JC, Jurus C, Quémeneur T, Leandri C, Saby JC, Lance G, Giannoukas A, Saleptsis V, Koutsias S, Saratzis N, Giannopoulos A, Katsamouris A, Kostas T, Tsetis D, Lazarides M, Filis K, Gerasimidis T, Papacharalambous G, Tsoupanos S, Gedins M, Kisis K, Zelobovskis J, Nokikovs N, Smolakova V, Zvirgzdins V, Ivanova P, Udris I, Bugán V, Komová J, Dzupina A, Horvát P, Bojdova E, Lasan I, Lasanová Z, Jascur J, Vacula I, Dostálová K, Andreozzi G, Camporese G, Verlato F, Davì G, Lessiani G, Pesavento R, Minotto I, Siragusa S, Parisi R, Imberti D, Prisco D, Lozano Vilardell P, Merino O, Acín García F, Cañibano C, Marinello Roura J, Alvarez Fernández J, Trujillo Santos J, Blanes Mompo J, Giménez Gaibar A, Izquierdo Lamoca L, Moreno Palomares J, Sánchez Gutiérrez A, Martínez Fernández S, Vaquero C, Muñoz Alvarez D, Cairols Castellote M, Grozdinski L, Gabriel M, Slowiński M, Dorobisz A, Milnerowicz A, Jawień A, Dereziński T, Strugala C, Jirka V, Skalicka L, Hirmerova J, Krcova E, Stanek F, Krivankova M, Kaha E, Aru A, Kamphuisen P, Gaastra M, Gerdes V, Damsté HS, ten Cate H, Valentijn R, Jeanneret C, Banyai M, Hayoz D, Kalka C, Willenberg T, Lugassy G, Lishner M, Hussein O]] , Fondaparinux for the treatment of superficial-vein thrombosis in the legs. NEW ENGL J MED 2010;363 (13):1222-1232 [PubMed]
Kaandorp SP, Goddijn M, Middeldorp S, Antithrombotic Medications and Recurrent Miscarriage REPLY. NEW ENGL J MED 2010;363 (9):888
Kaandorp SP, Goddijn M, van der Post JAM, Hutten BA, Verhoeve HR, Hamulyák K, Mol BW, Folkeringa N, Nahuis M, Papatsonis DNM, Büller HR, van der Veen F, Middeldorp S, Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. NEW ENGL J MED 2010;362 (17):1586-1596 [PubMed]
Kaandorp SP, Lauw MN, van der Schoot CE, Goddijn M, van der Veen F, Koene HR, Biemond BJ, Middeldorp S, Prevalence of JAK2V617F mutation in women with unexplained recurrent miscarriage. J THROMB HAEMOST 2010;8 (12):2837-2839 [PubMed]
Klok FA, Cohn DM, Middeldorp S, Scharloo M, Büller HR, van Kralingen KW, Kaptein AA, Huisman MV, Quality of life after pulmonary embolism: validation of the PEmb-QoL Questionnaire. J THROMB HAEMOST 2010;8 (3):523-532 [PubMed]
Lijfering WM, Middeldorp S, Veeger NJGM, Hamulyák K, Prins MH, Büller HR, van der Meer J, Risk of Recurrent Venous Thrombosis in Homozygous Carriers and Double Heterozygous Carriers of Factor V Leiden and Prothrombin G20210A. CIRCULATION 2010;121 (15):1706-1712 [PubMed]
Mäkelburg ABU, Veeger NJGM, Middeldorp S, Hamulyák K, Prins MH, Büller HR, Lijfering WM, Different risk of deep vein thrombosis and pulmonary embolism in carriers with factor V Leiden compared with non-carriers, but not in other thrombophilic defects. Results from a large retrospective family cohort study. HAEMATOLOGICA 2010;95 (6):1030-1033 [PubMed]
Mulder R, van Schouwenburg IM, Mahmoodi BK, Veeger NJGM, Mulder AB, Middeldorp S, Kluin-Nelemans HC, Lijfering WM, Associations between high factor VIII and low free protein S levels with traditional arterial thrombotic risk factors and their risk on arterial thrombosis: results from a retrospective family cohort study. THROMB RES 2010;126 (4):e249-e254 [PubMed]
Schreijer AJM, Hoylaerts MF, Meijers JCM, Lijnen HR, Middeldorp S, Büller HR, Reitsma PH, Rosendaal FR, Cannegieter SC, Explanations for coagulation activation after air travel. J THROMB HAEMOST 2010;8 (5):971-978 [PubMed]
Thijs W, Rabe KF, Rosendaal FR, Middeldorp S, Predominance of left-sided deep vein thrombosis and body weight. J THROMB HAEMOST 2010;8 (9):2083-2084 [PubMed]
Wichers IM. Unsolved issues in etiology and treatment of venous thrombosis. s.l.: s.n.; 2010. 188p. ISBN 9789490122980 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Büller HR; copromotor(s): Middeldorp S, Tanck MWT)
Yusuf E, Nelissen RG, Ioan-Facsinay A, Stojanovic-Susulic V, Degroot J, van Osch G, Middeldorp S, Huizinga TWJ, Kloppenburg M, Association between weight or body mass index and hand osteoarthritis: a systematic review. ANN RHEUM DIS 2010;69 (4):761-765 [PubMed]
Abdelmalik N, Ruhé HG, Barwari K, van den Dool EJ, Meijers JCM, Middeldorp S, Büller HR, Schene AH, Kamphuisen PW, Het effect van de selectieve serotonineheropnameremmer paroxetine op de bloedplaatjesfunctie wordt beïnvloed door een SLC6A4-serotoninetransporterpolymorfisme. NED TIJDSCHR HEMATOL 2009;6 (6):211-219
Cohn DM, Nelis EA, Busweiler LA, Kaptein AA, Middeldorp S, Quality of life after pulmonary embolism: the development of the PEmb-QoL questionnaire. J THROMB HAEMOST 2009;7 (6):1044-1046 [PubMed]
Cohn D, Vansenne F, de Borgie C, Middeldorp S, Thrombophilia testing for prevention of recurrent venous thromboembolism. COCHRANE DB SYST REV 2009;2009 (1):CD007069 [PubMed]
Folkeringa N, Korteweg FJ, Veeger NJGM, Middeldorp S, Hamulyak K, Prins MH, Erwich JJHM, Büller HR, van der Meer J, Thrombin activatable fibrinolysis inhibitor (TAFI) is not associated with fetal loss, a retrospective study. THROMB RES 2009;123 (3):511-514 [PubMed]
Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S, Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. COCHRANE DB SYST REV 2009;2009 (1):CD004734 [PubMed]
Knol HM, Veeger NJGM, Middeldorp S, Hamulyák K, van der Meer J, High thrombin-activatable fibrinolysis inhibitor levels may protect against recurrent fetal loss. J THROMB HAEMOST 2009;7 (5):903-906 [PubMed]
Krekel NMA, Coppens M, Büller HR, Middeldorp S, Reliability of questionnaires on the use of thromboprophylaxis. J THROMB HAEMOST 2009;7 (6):1042-1043 [PubMed]
Kuipers S. Air travel and venous thrombosis. Leiden: s.n.; 2009. 117p. ISBN 978-94-90122-49-2 Proefschrift Rijksuniversiteit Leiden, Faculteit Geneeskunde, onderzoek in AMC-UvA. (Promotor(s): Rosendaal FR, Büller HR; copromotor(s): Middeldorp S, Cannegieter SC)
Lijfering WM, Brouwer JLP, Veeger NJGM, Bank I, Coppens M, Middeldorp S, Hamulyak K, Prins MH, Buller HR, van der Meer J, Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. BLOOD 2009;113 (21):5314-5322 [PubMed]
Lijfering WM, Veeger NJGM, Middeldorp S, Hamulyák K, Prins MH, Büller HR, van der Meer J, A lower risk of recurrent venous thrombosis in women compared with men is explained by sex-specific risk factors at time of first venous thrombosis in thrombophilic families. BLOOD 2009;114 (10):2031-2036 [PubMed]
Mäkelburg ABU, Lijfering WM, Middeldorp S, Hamulyák K, Veeger NJGM, Prins MH, Büller HR, van der Meer J, Low absolute risk of venous and arterial thrombosis in hyperhomocysteinaemia - A prospective family cohort study in asymptomatic subjects. THROMB HAEMOSTASIS 2009;101 (1):209-212 [PubMed]
Middeldorp S, Epidemiology of hormone-related venous thromboembolism. THROMB RES 2009;123 (Suppl. 2):S65-S69 [PubMed]
Minnee RC, Middeldorp S, Legemate DA, Malformatie van de V. cava inferior, een risicofactor voor diepveneuze trombose. NED TIJDSCHR GENEESKD 2009;153 (11):496-500 [PubMed]
Wichers IM, Garcia AA, Tanck MWT, Middeldorp S, Reitsma PH, No linkage for venous thrombosis at a candidate region on chromosome 18 in Dutch thrombophilic families. J THROMB HAEMOST 2009;7 (7):1239-1240 [PubMed]
Wichers IM, Tanck MWT, Meijers JCM, Lisman T, Reitsma PH, Rosendaal FR, Büller HR, Middeldorp S, Assessment of coagulation and fibrinolysis in families with unexplained thrombophilia. THROMB HAEMOSTASIS 2009;101 (3):465-470 [PubMed]
Abdelmalik N, Ruhé HG, Barwari K, van den Dool EJ, Meijers JCM, Middeldorp S, Büller HR, Schene AH, Kamphuisen PW, Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism. J THROMB HAEMOST 2008;6 (12):2168-2174 [PubMed]
Akl EA, van Doormaal FF, Barba M, Kamath G, Kim SY, Kuipers S, Middeldorp S, Yosuico V, Dickinson HO, Schünemann HJ, Parenteral anticoagulation may prolong the survival of patients with limited small cell lung cancer: a Cochrane systematic review. J EXP CLIN CANC RES 2008;27:4 [PubMed]
Buller H, Deitchman D, Prins M, Segers A [Contributors: Büller H, Brenner B, Brighton T, Chlumsky J, Davidson B, Decousus H, Eriksson H, Jacobson B, van der Meer J, Minar E, Piovella F, Tomkowski W, Prins M, Baarslag H, Brandjes D, Bergqvist D, Laporte S, Mismetti P, Baker R, Blombery P, Chong B, Gallus A, Gan E, Salem H, Hirschl M, Pilger E, Kovarova K, Malý J, Matoska P, Patek F, Spacek R, Vitovec M, Zak J, Emmerich J, Lacroix P, Mottier D, Quere I, Roy P, Schmidt J, Elias M, Gavish D, Hoffman R, Hussein O, Lishner M, Lugassy G, Schliamser L, Shpilberg O, Varon D, Zeltser D, Ambrosio G, Ghirarduzzi A, Imberti D, Porreca E, Prandoni P, Jawien A, Nizankowski R, Skorski M, Witkiewicz W, Zawilska K, Engelbrecht J, v Marle J, Wright N, Aagesen J, Agren A, Jonson T, Lärfars G, Wallen T, ten Cate H, Kooy MvM, Middeldorp S, de Swart K, Garcia D, Lyons R, Rehm J, Spyropoulos A]] , Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study. J THROMB HAEMOST 2008;6 (8):1313-1318 [PubMed]
Cohn DM, Middeldorp S, Vroegtijdige beëindiging van het onderzoek naar het nut van trombofilietests bij een eerste veneuze trombo-embolie: het NOSTRADAMUS-onderzoek. NED TIJDSCHR GENEESKD 2008;152 (38):2093-2094 [PubMed]
Cohn DM, Vansenne F, Kaptein AA, de Borgie CAJM, Middeldorp S, The psychological impact of testing for thrombophilia: a systematic review. J THROMB HAEMOST 2008;6 (7):1099-1104 [PubMed]
Coppens M. Thrombophilia. s.l.: s.n.; 2008. 135p. ISBN 9789090227450 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Buller HR; copromotor(s): Middeldorp S)
Coppens M, Reijnders JH, Middeldorp S, Doggen CJM, Rosendaal FR, Testing for inherited thrombophilia does not reduce the recurrence of venous thrombosis. J THROMB HAEMOST 2008;6 (9):1474-1477 [PubMed]
Folkeringa N, Coppens M, Veeger NJGM, Bom VJJ, Middeldorp S, Hamulyak K, Prins MH, Büller HR, van der Meer J, Absolute risk of venous and arterial thromboembolism in thrombophilic families is not increased by high thrombin-activatable fibrinolysis inhibitor (TAFI) levels. THROMB HAEMOSTASIS 2008;100 (1):38-44 [PubMed]
Homsma SJM, Huijgen R, Middeldorp S, Sijbrands EJG, Kastelein JJP, Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance. EUR J HUM GENET 2008;16 (1):14-17 [PubMed]
Homsma SJM, Huijgen R, Middeldorp S, Sijbrands EJG, Kastelein JJP, Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance [Corrigendum]. EUR J HUM GENET 2008;16 (2):275 [PubMed]
Lijfering WM, Coppens M, Veeger NJGM, Middeldorp S, Hamulyák K, Prins MH, Büller HR, van der Meer J, Hyperhomocysteinemia is not a risk factor for venous and arterial thrombosis, and is associated with elevated factor VIII levels. THROMB RES 2008;123 (2):244-250 [PubMed]
Middeldorp S, Heparin: from animal organ extract to designer drug. THROMB RES 2008;122 (6):753-762 [PubMed]
Middeldorp S, van Hylckama Vlieg A, Does thrombophilia testing help in the clinical management of patients?. BRIT J HAEMATOL 2008;143 (3):321-335 [PubMed]
Rodger MA, Paidas M, McLintock C, Claire M, Middeldorp S, Kahn S, Martinelli I, Hague W, Rosene Montella K, Greer I, Inherited thrombophilia and pregnancy complications revisited. OBSTET GYNECOL 2008;112 (2 Part 1):320-324 [PubMed]
Squizzato A, Romualdi E, Middeldorp S, Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia. COCHRANE DB SYST REV 2008;2008 (2):CD006503 [PubMed]
van Doormaal FF, Büller HR, Middeldorp S, Development in anticoagulant therapy. CRIT REV ONCOL HEMAT 2008;66 (2):145-154 [PubMed]
Wichers IM, Haighton M, Büller HR, Middeldorp S, A retrospective analysis of patients treated for superficial vein thrombosis. NETH J MED 2008;66 (10):423-427 [PubMed]
Akl EA, van Doormaal FF, Barba M, Kamath G, Kim SY, Kuipers S, Middeldorp S, Yosuico V, Dickinson HO, Schünemann HJ, Parenteral anticoagulation for prolonging survival in patients with cancer who have no other indication for anticoagulation. COCHRANE DB SYST REV 2007;2007 (3):CD006652 [PubMed]
Bank I, van de Poel MHW, Coppens M, Hamulyák K, Prins MH, van der Meer J, Veeger NJGM, Büller HR, Middeldorp S, Absolute annual incidences of first events of venous thromboembolism and arterial vascular events in individuals with elevated FVIII:c. A prospective family cohort study. THROMB HAEMOSTASIS 2007;98 (5):1040-1044 [PubMed]
Cohn DM, Middeldorp S, Een multicentrisch gerandomiseerd klinisch onderzoek naar het nut van trombofilietests bij een eerste veneuze trombo-embolie: het NOSTRADAMUS-onderzoek. NED TIJDSCHR GENEESKD 2007;151 (6):371-373 [PubMed]
Cohn DM, Middeldorp S, Necessity of screening for thrombophilia at diagnosis of venous thromboembolism: outline of the NOSTADAMUS intervention trial.. J THROMB HAEMOST 2007;5 (Suppl. 2):P-M-470
Cohn DM, Middeldorp S, Trombofiliescreening bij VTE: het NOSTRADAMUS onderzoek. NED TIJDSCHR HEMATOL 2007;4:144-145
Cohn DM, Middeldorp S. Wanneer is bij het optreden van long-embolieën trombofilie-onderzoek zinnig? in: Asin J, Koppers RJH, Ten Velde GPM, editors. Longartsen Vademecum. Houten: A.J.J.M. van Meyel; 2007. jaargang 10, nr. 9, p. 1-5
Cohn DM, Roshani S, Middeldorp S, Thrombophilia and venous thromboembolism: implications for testing. SEMIN THROMB HEMOST 2007;33 (6):573-581 [PubMed]
Coppens M, Folkeringa N, Teune MJ, Hamulyak K, van der Meer J, Prins MH, Buller HR, Middeldorp S, Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutation: reply to a rebuttal. J THROMB HAEMOST 2007;5 (9):1992-1994 [PubMed]
Coppens M, Folkeringa N, Teune MJ, Hamulyak K, van der Meer J, Prins MH, Buller HR, Middeldorp S, Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations. J THROMB HAEMOST 2007;5 (7):1444-1448 [PubMed]
Coppens M, van Mourik JA, Eckmann CM, Buller HR, Middeldorp S, Current practise of testing for inherited thrombophilia. J THROMB HAEMOST 2007;5 (9):1979-1981 [PubMed]
Di Nisio M. Thrombosis and cancer: advances in diagnosis and prognosis. s.l.: s.n.; 2007. 212p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Richel DJ, Buller HR; copromotor(s): Middeldorp S)
Di Nisio M, Middeldorp S, Wichers IM, Treatment for superficial thrombophlebitis of the leg. COCHRANE DB SYST REV 2007;2007 (1):CD004982 [PubMed]
Di Nisio M, Wichers IM, Middeldorp S, Treatment for superficial thrombophlebitis of the leg. COCHRANE DB SYST REV 2007;2007 (2):CD004982 [PubMed]
Hamerlynck JVTH, Middeldorp S, Hooft L, Uit de Cochrane Library: fosfodiësteraseremmers effectief bij diabetici met erectiestoornissen. NED TIJDSCHR GENEESKD 2007;151 (38):2101-2104 [PubMed]
Keller TT, Squizzato A, Middeldorp S, Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease. COCHRANE DB SYST REV 2007;2007 (3):CD005158 [PubMed]
Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Buller HR, Rosendaal FR, The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations. PLOS MED 2007;4 (9):e290-1514 [PubMed]
Kuipers S, Schreijer AJM, Cannegieter SC, Bueller HR, Rosendaal FR, Middeldorp S, Travel and venous thrombosis: a systematic review. J INTERN MED 2007;262 (6):615-634 [PubMed]
Lijfering WM, Coppens M, van de Poel MHW, Middeldorp S, Hamulyak K, Bank I, Veeger NJGM, Prins MH, Bueller HR, van der Meer J, The risk of venous and arterial thrombosis in hyperhomocysteinaemia is low and mainly depends on concomitant thrombophilic defects. THROMB HAEMOSTASIS 2007;98 (2):457-463 [PubMed]
Middeldorp S, Pregnancy failure and heritable thrombophilia. SEMIN HEMATOL 2007;44 (2):93-97 [PubMed]
Middeldorp S, Thrombophilia and pregnancy complications: cause or association?. J THROMB HAEMOST 2007;5 (Suppl. 1):276-282 [PubMed]
Middeldorp S, Levi M, Thrombophilia: an update. SEMIN THROMB HEMOST 2007;33 (6):563-572 [PubMed]
Coppens M, Kaandorp SP, Middeldorp S, Inherited thrombophilias. OBSTET GYN CLIN N AM 2006;33 (3):357-374 [PubMed]
Coppens M, van de Poel MH, Bank I, Hamulyak K, van der Meer J, Veeger NJ, Prins MH, Buller HR, Middeldorp S, A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation. BLOOD 2006;108 (8):2604-2607 [PubMed]
Hamerlynck JVTH, Middeldorp S, Scholten RJPM, Uit de Cochrane Library: door dragen van elastische kousen tijdens langeafstandsvluchten minder kans op asymptomatische diepe veneuze trombose. NED TIJDSCHR GENEESKD 2006;150 (45):2486-2488 [PubMed]
Hamerlynck JVTH, Middeldorp S, Scholten RJPM, Uit de Cochrane Library: door zonlicht beschadigde huid te verbeteren met retinoïdecrèmes en niet met andere lokale behandelingen. NED TIJDSCHR GENEESKD 2006;150 (3):140-142 [PubMed]
Hamerlynck JVTH, Middeldorp S, Scholten RJPM, Uit de Cochrane Library: effectieve maatregelen beschikbaar voor valpreventie bij ouderen. NED TIJDSCHR GENEESKD 2006;150 (7):374-376 [PubMed]
Hamerlynck JVTH, Middeldorp S, Scholten RJPM, Uit de Cochrane Library: met postmenopauzale hormonale substitutietherapie geen bescherming tegen hart-vaatziekte, wel meer kans op veneuze trombo-embolie. NED TIJDSCHR GENEESKD 2006;150 (10):546-548 [PubMed]
Kuipers S, Cannegieter SC, Middeldorp S, Rosendaal FR, Büller HR, Use of preventive measures for air travel-related venous thrombosis in professionals who attend medical conferences. J THROMB HAEMOST 2006;4 (11):2373-2376 [PubMed]
Middeldorp S, Het ALIFE-onderzoek: herhaalde miskramen en het mogelijke nut van antistollingsbehandeling bij vrouwen met en zonder erfelijke trombofilie. NED TIJDSCHR HEMATOL 2006;3 (1):39-40
Middeldorp S, Goddijn M, Herhaalde miskramen en het mogelijke nut van antistollingsbehandeling. TIJDSCHR VERLOSKUNDIGEN 2006;85:29-33
Middeldorp S, Goddijn M, Herhaalde miskramen en trombofilie. NED TIJDSCHR GENEESKD 2006;150 (4):189-193 [PubMed]
Schreijer AJM, Cannegieter SC, Meijers JCM, Middeldorp S, Büller HR, Rosendaal FR, Activation of coagulation system during air travel: a crossover study. LANCET 2006;367 (9513):832-838 [PubMed]
Bank I, Libourel EJ, Middeldorp S, Hamulyák K, van Pampus ECM, Koopman MMW, Prins MH, van der Meer J, Büller HR, Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis. J THROMB HAEMOST 2005;3 (1):79-84 [PubMed]
Buller HR, Sohne M, Middeldorp S, Treatment of venous thromboembolism. J THROMB HAEMOST 2005;3 (8):1554-1560 [PubMed]
Deguchi H, Bouma BN, Middeldorp S, Lee YM, Griffin JH, Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide. J THROMB HAEMOST 2005;3 (5):935-938 [PubMed]
Di Nisio M, Middeldorp S, Büller HR, Direct thrombin inhibitors. NEW ENGL J MED 2005;353 (10):1028-1040 [PubMed]
Di Nisio M, Peters LW, Middeldorp S, Anticoagulants for the treatment of recurrent pregnancy loss in women without antiphospholipid syndrome. COCHRANE DB SYST REV 2005;2005 (2):CD004734 [PubMed]
Douketis JD, Julian JA, Kearon C, Anderson DR, Crowther MA, Bates SM, Barone M, Piovella F, Turpie AG, Middeldorp S, van Nguyen P, Prandoni P, Wells PS, Kovacs MJ, Macgillavry MR, Costantini L, Ginsberg JS, Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control study. J THROMB HAEMOST 2005;3 (5):943-948 [PubMed]
Hamerlynck JVTHH, Middeldorp S, Scholten RJPM, Uit de Cochrane Library: introductie. NED TIJDSCHR GENEESKD 2005;149 (41):2278
Hamerlynck JVTH, Middeldorp S, Uit de Cochrane Library: routinematig gebruik van een maagsonde na een abdominale operatie niet zinvol. NED TIJDSCHR GENEESKD 2005;149 (41):2279-2280 [PubMed]
Hamerlynck JVTH, Middeldorp S, Uit de Cochrane Library: routinematig losmaken van de vliezen ('strippen') ter inleiding van de baring bij aterme zwangeren wel effectief, maar niet altijd zinvol. NED TIJDSCHR GENEESKD 2005;149 (45):2508-2510 [PubMed]
Hamerlynck JVT, Middeldorp S, Scholten RJPM, Uit de Cochrane Library: elektrisch tandenpoetsen met oscillerende roterende beweging beter tegen tandplaque en gingivitis dan poetsen met een conventionele tandenborstel. NED TIJDSCHR GENEESKD 2005;149 (48):2673-2675 [PubMed]
Libourel EJ, Bank I, Veeger NJGM, Hamulyàk K, Middeldorp S, Prins MH, Büller HR, van der Meer J, Protein S type III deficiency is no risk factor for venous and arterial thromboembolism in 168 thrombophilic families: a retrospective study. BLOOD COAGUL FIBRIN 2005;16 (2):135-140 [PubMed]
Middeldorp S, Hormone replacement therapy and arterial thrombotic disease. THROMB RES 2005;115 (Suppl. 1):68-71 [PubMed]
Middeldorp S, Low-molecular-weight heparin to prevent pregnancy loss in thrombophilic women: need for placebo-controlled studies. J THROMB HAEMOST 2005;3 (4):788-789
Middeldorp S, Oral contraceptives and the risk of venous thromboembolism. GENDER MED 2005;2 (Suppl. A):S3-S9 [PubMed]
Verdonkschot AEM, Vasmel WLE, Middeldorp S, van der Schoot JTM, Skin reactions due to low molecular weight heparin in pregnancy: a strategic dilemma. ARCH GYNECOL OBSTET 2005;271 (2):163-165 [PubMed]
Wichers IM, Di Nisio M, Büller HR, Middeldorp S, Treatment of superficial vein thrombosis to prevent deep vein thrombosis and pulmonary embolism: a systematic review. HAEMATOLOGICA 2005;90 (5):672-677 [PubMed]
Bank I, Libourel EJ, Middeldorp S, van Pampus ECM, Koopman MMW, Hamulyák K, Prins MH, van der Meer J, Büller HR, Prothrombin 20210A mutation - A mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study. ARCH INTERN MED 2004;164 (17):1932-1937 [PubMed]
Bank I, Scavenius MPRB, Büller HR, Middeldorp S, Social aspects of genetic testing for factor V leiden mutation in healthy individuals and their importance for daily practice. THROMB RES 2004;113 (1):7-12 [PubMed]
Libourel EJ, Baljé-Volkers Degrees CP, Hamulyàk K, Prins MH, Middeldorp S, Büller HR, van der Meer J, High factor VIII plasma levels as a risk factor for venous thrombosis: no evidence of inheritance from a family cohort study. HAEMATOLOGICA 2004;89 (1):118-120 [PubMed]
Locadia M, Bossuyt PMM, Stalmeier PFM, Sprangers MAG, van Dongen CJJ, Middeldorp S, Bank I, van der Meer J, Hamulyák K, Prins MH, Treatment of venous thromboembolism with vitamin K antagonists: patients' health state valuations and treatment preferences. THROMB HAEMOSTASIS 2004;92 (6):1336-1341 [PubMed]
Middeldorp S, ALIFE: onderzoek naar het nut van stollingsremmers tegen miskramen. NIEUWSBRIEF VASC GENEESKD 2004;1 (3):21-ev.
Middeldorp S, Low-molecular-weight heparin to prevent pre-eclampsia: there is no evidence and potential harm. NETH J MED 2004;62 (3):69-70 [PubMed]
Middeldorp S, Peters M, Diagnose in beeld (177). Een levenloze zuigeling. NED TIJDSCHR GENEESKD 2004;148 (23):1168; author reply 1168 [PubMed]
Middeldorp S, Peters M, [Diagnostic image (177). A lifeless infant. Shaken baby syndrome]. NED TIJDSCHR GENEESKD 2004;148 (23):1168--
Middeldorp S, van de Poel MH, Bank I, Hamulyák K, Libourel EJ, Koopman MMW, Prins MH, van der Meer J, Büller HR, Unselected women with elevated levels of factor VIII:C or homocysteine are not at increased risk for obstetric complications. THROMB HAEMOSTASIS 2004;92 (4):787-790 [PubMed]
Middeldorp S, van der Meer J. Veneuze trombo-embolie in: Büller HR, Kastelein JJP, Stroes ESG, editors. Vasculaire geneeskunde; 2e herz. dr. Alphen a/d Rijn: Van Zuiden; 2004., p. 223-235
Weitz JI, Middeldorp S, Geerts W, Heit JA, Thrombophilia and new anticoagulant drugs. HEMATOL-AM SOC HEMAT 2004;2004:424-438 [PubMed]
Wichers IM, Middeldorp S, Zin van screenen op trombofilie bij patiënten met een eerste veneuze trombo-embolie. NED TIJDSCHR HEMATOL 2004;1 (2):42-47
Bank I. Aetiology and treatment of venous thromboembolism. S.l.: s.n.; 2003. 196p. ISBN 90-09017115-0 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Büller HR; copromotor(s): Middeldorp S)
Bank I, Libourel EJ, Middeldorp S, van der Meer J, Büller HR, High rate of skin complications due to low-molecular-weight heparins in pregnant women. J THROMB HAEMOST 2003;1 (4):859-861 [PubMed]
Bank I, Tick LW, Hutten BA, Kramer MHH, Middeldorp S, Büller HR, Acquired and inherited thrombophilic factors and the risk for residual venous thrombosis. PATHOPHYSIOL HAEMO T 2003;33 (4):192-196 [PubMed]
Middeldorp S, Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications - No. J THROMB HAEMOST 2003;1 (10):2073-2074 [PubMed]
Middeldorp S, Büller HR, Prins MH, Risk for venous thromboembolism in carriers of the factor V Leiden mutation - In response. ANN INTERN MED 2003;138 (1):76-77
Libourel EJ, Bank I, Meinardi JR, Baljé -Volkers CP, Hamulyak K, Middeldorp S, Koopman MMW, van Pampus ECM, Prins MH, Büller HR, van der Meer J, Co-segregation of thrombophilic disorders in factor V Leiden carriers; the contributions of factor VIII, factor XI, thrombin activatable fibrinolysis inhibitor and lipoprotein(a) to the absolute risk of venous thromboembolism. HAEMATOLOGICA 2002;87 (10):1068-1073 [PubMed]
Meinardi JR, Middeldorp S, de Kam PJ, Koopman MMW, van Pampus ECM, Hamulyák K, Prins MH, Büller HR, van der Meer J, The incidence of recurrent venous thromboembolism in carriers of factor V Leiden is related to concomitant thrombophilic disorders. BRIT J HAEMATOL 2002;116 (3):625-631 [PubMed]
Middeldorp S, Büller HR, Vandenbroucke JP, Helmerhorst FM, Rosendaal FR, Nadelige cardiovasculaire effecten van postmenopauzale hormonale suppletie. NED TIJDSCHR GENEESKD 2002;146 (45):2123-2127 [PubMed]
Middeldorp S, van der Meer J. Veneuze trombo-embolie in: Büller HR, Kastelein JJP, Stroes ESG, editors. Vasculaire geneeskunde. S.l.: Van Zuiden Communications; 2002., p. 197-208
Middeldorp S, van der Meer J, Hamulyák K, Büller HR, A rebuttal: Counseling pregnant women with factor V Leiden homozygosity: Use absolute instead of relative risks. THROMB HAEMOSTASIS 2002;87 (2):360-361 [PubMed]
Meinardi JR, Middeldorp S, de Kam PJ, Koopman MM, van Pampus EC, Hamulyák K, Prins MH, Büller HR, van der Meer J, Risk of venous thromboembolism in carriers of factor V Leiden with a concomitant inherited thrombophilic defect: a retrospective analysis. BLOOD COAGUL FIBRIN 2001;12 (8):713-720 [PubMed]
Middeldorp S, Libourel EJ, Hamulyák K, van der Meer J, Büller HR, The risk of pregnancy-related venous thromboembolism in women who are homozygous for factor V Leiden. BRIT J HAEMATOL 2001;113 (2):553-555 [PubMed]
Middeldorp S, Meinardi JR, Koopman MM, van Pampus EC, Hamulyák K, van der Meer J, Prins MH, Büller HR, A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism. ANN INTERN MED 2001;135 (5):322-327 [PubMed]
Middeldorp S, Prins MH, Büller HR, Geen indicatie voor trombofilieonderzoek bij patiënten met idiopathische veneuze trombo-embolie en hun familieleden. NED TIJDSCHR GENEESKD 2001;145 (22):1047-1051 [PubMed]
Middeldorp S, Rosing J, Bouma BN, Büller HR, Effecten van orale anticonceptiva van de tweede en de derde generatie op de hemostase. NED TIJDSCHR GENEESKD 2001;145 (6):252-256 [PubMed]
Vandenbroucke JP, Rosing J, Bloemenkamp KW, Middeldorp S, Helmerhorst FM, Bouma BN, Rosendaal FR, Oral contraceptives and the risk of venous thrombosis. NEW ENGL J MED 2001;344 (20):1527-1535 [PubMed]
Bank I, Middeldorp S, Büller HR, Hereditary and acquired thrombophilia. SEMIN RESP CRIT CARE 2000;21 (6):483-491 [PubMed]
Bijsterveld NR, Middeldorp S, Berends F, Büller HR, Monitoring therapy with vitamin K antagonists in patients with lupus anticoagulant: effect on different tests for INR determination. J THROMB THROMBOLYS 2000;9 (3):263-269 [PubMed]
Franco RF, Middeldorp S, Meinardi JR, van Pampus EC, Reitsma PH, Factor XIII Val34Leu and the risk of venous thromboembolism in factor V Leiden carriers. BRIT J HAEMATOL 2000;111 (1):118-121 [PubMed]
Meijers JC, Middeldorp S, Tekelenburg W, van den Ende AE, Tans G, Prins MH, Rosing J, Büller HR, Bouma BN, Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis: a randomized cross-over study of two low-dose oral contraceptives. THROMB HAEMOSTASIS 2000;84 (1):9-14 [PubMed]
Middeldorp S, Büller HR, How to decide on the optimal duration of anticoagulatn therapy in carriers of the factor V Leiden mutation. THROMB HAEMOSTASIS 2000;84 (5):740-741 [PubMed]
Middeldorp S, Meijers JC, van den Ende AE, van Enk A, Bouma BN, Tans G, Rosing J, Prins MH, Büller HR, Effects on coagulation of levonorgestrel- and desogestrel-containing low dose oral contraceptives: a cross-over study. THROMB HAEMOSTASIS 2000;84 (1):4-8 [PubMed]
Tans G, Curvers J, Middeldorp S, Thomassen MC, Meijers JC, Prins MH, Bouma BN, Büller HR, Rosing J, A randomized cross-over study on the effects of levonorgestrel- and desogestrel-containing oral contraceptives on the anticoagulant pathways. THROMB HAEMOSTASIS 2000;84 (1):15-21 [PubMed]
Levi M, Middeldorp S, Büller HR, Oral contraceptives and hormonal replacement therapy cause an imbalance in coagulation and fibrinolysis which may explain the increased risk of venous thromboembolism. CARDIOVASC RES 1999;41 (1):21-24 [PubMed]
Mainardi JR, Pelsma PM, Koning H, van der Meer J, Middeldorp S, Büller HR, Hamulyák K, Double-homozygosity for factor V Leiden and the prothrombin gene G20210A variant in a young patient with idiopathic venous thrombosis. BLOOD 1999;94 (5):1828-1829 [PubMed]
Meinardi JR, Middeldorp S, de Kam PJ, Koopman MM, van Pampus EC, Hamulyák K, Prins MH, Büller HR, van der Meer J, Increased risk for fetal loss in carriers of the factor V Leiden mutation. ANN INTERN MED 1999;130 (9):736-739 [PubMed]
Rosing J, Middeldorp S, Curvers J, Christella M, Thomassen LG, Nicolaes GA, Meijers JC, Bouma BN, Büller HR, Prins MH, Tans G, Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study. LANCET 1999;354 (9195):2036-2040 [PubMed]
de Winter RJ, Middeldorp S, Gaffar S, Koch KT, Piek JJ, Levi M, Reitsma PH, Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation. CATHET CARDIOVASC DIAGN 1998;44 (4):427-430 [PubMed]
Middeldorp S, Henkens CM, Koopman MM, van Pampus EC, Hamulyák K, van der Meer J, Prins MH, Büller HR, The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis. ANN INTERN MED 1998;128 (1):15-20 [PubMed]
Middeldorp S, van der Meer J, Factor V:Q506 mutation-resistance to activated protein C (APC): clinical implications with respect to family screening. SEMIN THROMB HEMOST 1998;24 (4):363-366 [PubMed]
Key publications

Connolly SJ, Milling TJ Jr, Eikelboom JW, Gibson CM, Curnutte JT, Gold A, Bronson MD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen AT, Beyer-Westendorf J, Albaladejo P, Lopez-Sendon J, Goodman S, Leeds J, Wiens BL, Siegal DM, Zotova E, Meeks B, Nakamya J, Lim WT, Crowther M [Contributors: Connolly SC, Crowther M, Eikelboom J, Gibson M, Milling TJ, Albaladejo P, Cohen A, Lopez-Sendon J, Middeldorp S, Schmidt J, Verhamme P, Beyer-Westendorf J, Wyse DG, Garcia D, Prins M, Nakamya J, Büller HR, Mahaffey K, Alexander J, Demchuk A, Raskob G, Schulman S, Meeks B, Zotova E, Holadyk-Gris I, Pinto T, Behr M, Lim T, Anand R, Bastani A, Caterino J, Clark C, Concha M, Cornell J, Eriksson E, Fermann G, Fulmer J, Goldstein J, Kereiakes D, Lotfipour S, Milling T, Moll S, Pallin D, Patel N, Refaai M, Rehman M, Schmaier A, Schwarz E, Shillinglaw W, Sinert R, Singer A, Takata T, Venkat A, Weinstein D, Welker J, Welsby I, Wiener S, Wilson J, Blostein M, van Keer L, Verschuren F, Coppens M, van Wissen S, Alikhan R, Breen K, Hall R]] , Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors. NEW ENGL J MED 2016;375 (12):1131-1141 [PubMed]
Büller HR, Décousus H, Grosso MA, Mercuri M, Middeldorp S, Prins MH, Raskob GE, Schellong SM, Schwocho L, Segers A, Shi M, Verhamme P, Wells P [Contributors: Büller H, Agnelli G, Angchaisuksiri P, Banyai M, Bauersachs R, van Bellen B, Blüguermann J, Boda Z, Bounameaux H, Brenner B, Brighton T, Castañon JD, Chechulov P, Chlumský Y, Cohen A, Davidson B, Decousus H, Eriksson H, Gallus A, Gudz I, Jacobson B, Heng LL, Lyons R, Meijer K, Minar E, Monreal M, Nakamura M, Oh D, Öngen G, Parakh R, Piovella F, Raskob G, Rehm J, Sandset PM, Schellong S, Smith M, Sokurenko G, Tomkowski W, Torp-Pedersen C, Verhamme P, Wang C, Wang Y, Weitz J, Wells P, Yanushko V, Yin WH, Prins M, Beenen L , Brandjes D, MacGillavry M, Kaplowitz N, Otten HM, Pessayre D, Peters R, Roos Y, Slagboom T, Eikelboom J, Crowther M, Roberts R, Vanassche T, Vandenbriele C, Debaveye B, Segers A, Dani V, van Bergen P, Gerrits P, Mercuri M, van Kranen R, Lanz H, Grosso M, Schwocho L, Kappelhoff J, Franc J, Shi M, Zhang G, Lin M, Crerand W, Giordano C, Skinner M, Hurley S, Lovelace G, Barrier R, Betcher J, Alvarez C, Amuchastegui LM, Blüguermann J, Cassettari A, Ceressetto J, Hrabar N, Macin S, Mahuad C, Oberti P, Santini F, Baker RI, Blombery P, Brighton T, Carroll P, Chong B, Coughlin P, Crispin P, Fletcher J, Gallus A, Serisier DJ, Tran H, Chan N, Stafford L, Ward C, Baghestanian M, Kyrle PA, Eischer L, Traby L, Marschang P, Mathies R, Pilger E, Brodmann M, Roithinger F, Weltermann A, Adzerikho I, Davidovskaya E, Gorokhovsky S, Maslianski B, Kulik A, Yanushka A, de Vleeschauwer P, Debing E, Duchateau J, Gustin M, Hainaut P, Vandekerkhof J, Verhamme P, Peerlinck K, Verstraeten P, Wautrecht JC, Motte S, Annichino-Bizzacchi JM, Mello TBT, Menezes FH, Burihan M, Cavalcanti M, Correa J, Correa de Carvalho F, Cukier A, Manenti E, Manenti ER, Sacilotto R, Timi JM, van Bellen B, Kahn SR, Kovacs M, Langner AL, VanSpronsen H, Ritchie B, Shafai-Sarshar R, Shivakumar S, Anderson D, Robinson K, Gallant B, Wells P, Karovitch A, Scarvelis D, Carrier M, Bai CX, Chen RC, Cheng ZZ, Du YC, Hu XY, Gu YQ, Hao QL, Sun SB, Wang C, Jiang L, Liu CJ, Liu CW, Liu S, Wang XX, Ye XF, Ma Z, Qin ZQ, Qin XJ, Tian HY, Wang YQ, Shi ZY, Wen FQ, Wu Q, Yang YH, Kuang TG, Yang H, Ying KJ, Ma GF, Yuan YD, Yu J, Gong XW, Zhang FX, Zhang J, Zhang SX, Zhang JW, Zhang L, Zhao JC, Huang B, Zhao J, Chlumsky J, Hola D, Hirmerova J, Hutyra M, Klimsa Z, Holub M, Kovarova K, Lang P, Ryba M, Podoubský R, Matoska P, Mayer O, Patek F, Tupa M, Spacek R, Urbanova R, Blazejova S, Vitovec M, Andersen B, Brønnum-Schou J, Dominguez H, Egstrup K, Auscher S, Jeppesen J, Asferg C, Vishram J, Nielsen H, Galsgaard I, Michaelsen M, Haugaard-Nielsen B, Ostergaard O, Poulsen SH, Torp-Pedersen C, Masik S, Kadarik M, Meriste S, Paumets M, Laheäär M, Raidjuk L, Accassat S, Buchmuller A, Mismetti P, Achkar A, Aquilanti S, Rifaï A, Breuil N, Schmidt J, Brisot D, Brousse C, de la Fuentes PT, Chakra M, Crestani B, Desormais I, Lacroix P, Diamand JM, El Kouri D, Clairand R, Elias A, Ferrari E, Doyen D, Chiche O, Grange C, Guenneguez H, Lacut K, Couturaud F, Mottier D, Leroux L, Lorcerie B, de Maistre E, Berthier S, Mahe I, Martin M, Meneveau N, Meyer G, Sanchez O, Montaclair K, Pavic M, Pernod G, Imbert B, Quere I, Galanaud JP, Roy PM, Sevestre MA, Simoneau G, Stephan D, Aleil B, Mirea C, Trinh-Duc A, von Bilderling PB, Beyer-Westendorf J, Werth S, Köhler C, Halbritter K, Diehm C, Espinola-Klein C, Weisser G, Franke D, Heuer H, Horacek T, Kahrmann G, Kroening R, Lawall H, Roecken M, Schellong SM, Pomper L, Voigts B, Bernhard S, Frommhold R, Stellbrink C, Boda Z, Ilonczai P, Olah Z, Razso K, Schlammadinger A, Farkas K, Kolossváry E, Szabó I, Frankfurter Z, Gasztonyi B, Gurzó M, Klucsik Z, Kovacs A, Szigeti S, Varga C, Landi A, Nyirati G, Pecsvarady Z, Riba M, Sámson Z, Sipos G, Szigyártó M, Sebő N, Szabó TJ, Toth K, Agarwal S, Arneja J, Babhulkar S, Balaji R, Banker D, Bhagavan NK, Bhonagiri S, Mehta A, Dayasagar Rao V, Desai P, Desai SC, Chandrashekar AR, Singh R, Deshpande A, Dharmadhikari A, Durairaj N, Ghaisas N, Gupta S, Jain R, Jindal R, Kamerkar D, Kothiwale VA, Kothurkar A, Kulkarni R, Kumar S, Mody B, Nagabhushan KN, Pandharpurkar HK, Joshi S, Parakh R, Grover T, Patel J, Patel K, Dudhagra N, Pawar N, Penurkar M, Pinjala R, Rai K, Rao B, Raval M, Raval A, Mehta P, Ravi Kishore AG, Saravanan S, Shetty P, Srinivas A, Suresh KR, Sumanthraj K, Girija KR, Vinod MV, Gavish D, Ashkenazy B, Braester A, Caraco Y, Elias M, Goldstein L, Grossman E, Lahav M, Lishner M, Lugassy G, Oliven A, Rachmilevitz R, Tzoran I, Brenner B, Yeganeh S, Zeltser D, Zimlichman R, Ageno W, Barillari G, Pasca S, Bortoluzzi C, Cattaneo M, Falanga A, Ghirarduzzi A, Lodigiani C, Picchi C, Iosub DI, Porreca E, Prandoni P, Quintavalla R, Siragusa S, Akita T, Aoyama T, Fujimoto K, Hanzawa K, Ikeda U, Iwata H, Kobayashi T, Kondo K, Kurimoto T, Maeda H, Mo M, Munemasa M, Murakami H, Nishi Y, Nishibe T, Nishigami K, Nunohiro T, Obayashi T, Satoh T, Satokawa H, Shimizu K, Shiroma H, Sonoda M, Suzuki Y, Taniguchi S, Tsujita K, Yamada N, Yasuda C, Yoshida H, Chang HJ, Choi WI, Kwon KY, Rho BH, Choi JS, Hong YS, Joh JH, Kim DJ, Kim HS, Kim SH, Kim YK, Kim KU, Kim JY, Kwon TW, Lee TS, Lim SY, Mun YC, Oh DY, Park KH, Yun WS, Yoon HI, Diaz-Castañon J, Flota LF, Galindo J, Gomez Lara J, Jerjes-Sanchez C, Palomar-Lever A, Rodriguez D, Higareda I, Boersma WG, de Graaff CS, Oudeman L, Brans E, Bredie SJH, Dees A, Erdkamp F, Peters F, Fijnheer R, Gerdes VEA, Griffioen A, Jie KSG, Meijer K, Kooistra H, Wiewel-Verschueren S, Middeldorp S, Kamphuisen PW, van Es J, Eerenberg ES, Swart Heikens J, ten Cate H, ten Wolde M, Hes R, Atalay S, Harper P, Merriman E, Ockelford P, Hulton MH, Phillips J, Royle G, Ford A, Smith M, Ghanima W, Amundsen H, Sandset PM, Abola MT, Ganzon MS, Germar A, Checinski P, Kwasniewski A, Tomkowski W, Zechowicz T, Apartsin K, Arutyunov G, Barbarash O, Burov Y, Chechulov P, Varaksina E, Chernyatina M, Gladchenko M, Belikov L, Fokin A, Gubenko A, Igor K, Olga M, Kazakov Y, Kazakov A, Krasavin V, Linev K, Plechev V, Shesternya P, Shkurin V, Shvalb P, Sokurenko G, Sonkin I, Remizov A, Chernykh K, Staroverov I, Subbotin Y, Zeltser M, Seletsky A, Iliynykh A, Zilber A, Zubareva N, Tkachenko I, Pakhomova A, Raghuram J, Ng HJ, Sin K, Adler D, Weber F, van der Jagt R, Basson M, Becker J, Ellis G, Isaacs R, Jacobson B, Louw S, van Rensburg J, Siebert H, Skosana F, van Marle J, van Zyl L, le Roux R, Williams P, Cereto F, Garcia-Bragado F, Miranda RT, Carlsson A, Eriksson H, Villegas-Scivetti M, Ottosson E, Sjalander A, Torstensson I, Banyai M, Afarideh R, Gallino A, Mazzolai L, Righini M, Staub D, Chen CJ, Chiang CE, Wang KL, Chiu KM, Huang JH, Lai WT, Pai PY, Lin KH, Wang JH, Wu CC, Yin WH, Huang CL, Angchaisuksiri P, Kulpraneet M, Rojnuckarin P, Öngen G, Duman B, Ozkan S, Savas I, Selçuk T, Tuncay E, Gerasymov V, Gubka O, Gudz I, Voloshyn M, Nikulnikov P, Danylets A, Prasol V, Rusyn V, Sergeev O, Shtutin O, Skupyy O, Tatarin A, Venger I, Cohen AT, Patel R, Hunt BJ, Kesteven P, Robson L, MacCallum P, Nokes T, Rose P, Acs P, Gordan L, Bhatia A, Ali M, Amin D, Masson J, Gavi E, Ayele E, Ayeni O, Canosa R, Chavous D, Chen D, Comerota A, Concha M, Cunanan-Bush M, Daboul N, Daggubati S, Dang N, DiBella N, Driver A, Dulgeroff A, Fraiz J, Friedlander A, Galvez A, Jani C, Johnson S, Khandelwal P, Kingsley E, Kingsley J, Hutchinson L, Lavender R, Lyons R, Guzley G, Martinez R, Metjian A, Moran J, Nadar V, Pish R, Pullman J, Quaranta AJ, Ravi C, Refaai M, Rehm J, Richards D, Richwine R, Sachdeva S, Seibert A, Sharma A, Stricklin D, Tannenbaum A, Tin-U C, Vora K, Watkins D, Willms D]] , Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism. NEW ENGL J MED 2013;369 (15):1406-1415 [PubMed]
Cunha MLR , Bakhtiari K, Peter J, Marquart JA, Meijers JCM, Middeldorp S, A novel mutation in the F5 gene (factor V Amsterdam) associated with bleeding independent of factor V procoagulant function. BLOOD 2015;125 (11):1822-1825 [PubMed]
de Jong PG, Goddijn M, Middeldorp S, Antithrombotic therapy for pregnancy loss. HUM REPROD UPDATE 2013;19 (6):656-673 [PubMed]
Reitsma PH, Versteeg HH, Middeldorp S, Mechanistic View of Risk Factors for Venous Thromboembolism. ARTERIOSCL THROM VAS 2012;32 (3):563-568 [PubMed]


All Publications

Curriculum Vitae

Saskia Middeldorp, MD, qualified as a medical doctor at the University of Amsterdam in 1992. She received her training in internal medicine at the Academic Medical Center in Amsterdam and obtained her board licence in 1999 (subspecialty Vascular Medicine, 2002). Since December 2010, she is professor and co-chair of the Department of Vascular Medicine of the Academic Medical Center. She leads the residency program of vascular medicine and is head of the trial unit of the Department. Her present research focuses on several aspects of hereditary and acquired thrombophilia, women’s issues in thrombosis and haemostasis, and the clinical evaluation of new anticoagulants.

Additional information:

Dr Middeldorp defended her thesis entitled “Clinical and laboratory studies in hereditary and acquired prothrombotic states” in 2000. She was Associate Professor of the Department of Vascular Medicine in the Academic Medical Center (until December 2006) and co-director of the Dutch Cochrane Centre (2003-2005). From December 2006 to July 2010, she was Associate Professor in the Departments of Clinical Epidemiology and Internal Medicine at the Leiden University Medical Center. She was project leader of the NEO Study, a large population-based cohort of obese individuals that aims to study the etiology of various conditions and diseases in obesity.

Professor Middeldorp held a research fellowship (2003-2007) and was Clinical Established Investigator (2008-2010) of the Netherlands Heart Foundation. She holds a VIDI grant from the Netherlands Organisation for Scientific Research (NWO) (2012-present). She is co-chair of the Scientific Subcommittee of Women’s Issues in Thrombosis and Haemostasis of the International Society of Thrombosis and Haemostasis (ISTH), a Member of the Advisory Board of The Journal of Thrombosis and Haemostasis (2001), is Editor of The Cochrane Collaborative Review Group on Peripheral Vascular Diseases (2003), Member of the Scientific Advisory Boards of the Netherlands Heart Foundation (2007-2010) and Dutch Thrombosis Foundation (2007). She has co-authored over 160 peer-reviewed papers and several book chapters, and reviews manuscripts for international scientific journals.
She is co-author of the Pregnancy chapter of the ACCP guidelines on Antithrombotic management (2012). 

Research programmes

Vascular Medicine

Lines of research are:
1) Reproductive issues in thrombosis and haemostasis. This includes the topic of
thrombophilia and reproduction that is subject of this research proposal. Furthermore,
diagnostic, prophylactic and therapeutic management of venous thromboembolism in
pregnant women is part of this research line.
2) Genetic and acquired risk factors for venous thromboembolism. This research line has
the overall aim to identify novel genetic risk factors, by means of classical linkage
analysis and next generation whole exome sequencing in families that have been
collected because of an unexplained tendency to familial venous thromboembolism. It
also aims to translate the findings to the clinical implications of thrombophilia.
3) New anticoagulant drugs. This research line includes the aim to identify determinants
of recurrent thrombosis and bleeding in patients using the new anticoagulant drugs
(collaboration Dr J.W. Eikelboom, McMaster University, Hamilton, Canada). Furthermore,
clinical application of the new drugs is part of this research line.
4) The applicant was project leader and initiated the NEO Study, a large populationbased
cohort of obese individuals that aims to study the etiology of various conditions
and diseases in obesity (2006-2010). She still collaborates on vascular aspects of obesity
(collaboration Prof. dr. F.R. Rosendaal, LUMC).

Faculty
Prof. dr. S. Middeldorp MD PhD
M. Coppens MD PhD

PhD Students
R. Bavalia
Drs. L.F.M. Beenen
I.M. Bistervels
Drs. M.P.A. Brekelmans
Drs. M.L.R. Cunha
Y.C.L. Haan
Drs. D.L. Horjus
Drs. F.A. Karamat
N. Kraaijpoel MD
Drs. T.E. van Mens
L.J.J. Scheres
Drs. I.L.M. Klaassen
W. Thijs MD (Leiden University Medical Center)

Prof. dr. H.R. Büller (Venous and arterial thromboembolic diseases)

Other research related activities
  • Contribution to guidelines and protocols, ACCP guidelines on use of anticoagulant drugs in pregnancy
  • Membership of medical or scientific committee, Nederlandse Hartstichting, WAC3 diagnose en therapie
  • Membership of medical or scientific committee, Nederlandse Trombosestichting, Wetenschappelijke Adviesraad
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Contribution to guidelines and protocols, Health Council on New Oral Anticoagulants 2012
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Contribution to guidelines and protocols, Health Council on New Oral Anticoagulants 2012
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Membership of advisory board / Consultant, GR (GezondheidsRaad, Dutch Health Council)
  • Contribution to guidelines and protocols, Health Council on New Oral Anticoagulants 2012
  • Contribution to guidelines and protocols, Health Council on New Oral Anticoagulants 2012
Current research funding
  • Adelphi Values Limited
  • AMC
  • AMC (Vrijgesteld)
  • Aspen Europe GmbH
  • BAYER B.V.
  • Bayer Healthcare Pharmaceuticals Inc.
  • Boehringer Ingelheim BV
  • CSL Behring GmbH
  • Daiichi Sankyo Europe GmbH
  • Daiichi-Sankyo Nederland B.V.
  • Erasmus MC
  • NIEUWE DEB IND
  • PAREXEL Nederland B.V.
  • Pfizer B.V. (4726)
  • Quintiles B.V.
  • Sanquin Blood Supply Foundation
  • Stichting AMC Foundation (Vrijgesteld)
  • Stichting Vascular Research Support
  • Trombose Stichting Nederland
  • ZonMw