• Principal Investigator
  • Male

Prof. dr. R. van Ree

Position: Professor
Main activities: Research
Specialisation: Molecular and Translational Allergology
foto R. van Ree is one of the AMC Principal Investigators
Focus of research: Research of the group of Ronald van Ree focuses on a number of inter-related basic and translational questions around IgE-mediated allergies, also referred to as type I allergies. The four major pairs of basic (B1-B4) and translational (T1-T4) questions addressed are:

Basic research:

B1 - What makes a protein an allergen?

This topic focuses on the role of intrinsic physico-chemical properties (such as protease resistance and type of post-translational modifications) and functional properties of proteins (enzymatic activity, ligand binding, PRR-binding) in shaping the process of sensitization and the induction of symptoms.

B2 - How is the process of sensitization regulated?

Obviously this question has overlap with the question “what makes a protein an allergen”, but it has a broader scope. The intrinsic properties of a protein are just part of the equation. On top of that, timing and level of exposure as well as the context in which the exposure takes place (environmental co-exposures such as pollutants, infections, exposure to non-pathogenic micro-organisms, diet, lifestyle, affluence) have impact on the process of skewing towards tolerance or sensitization and clinical disease.

B3 - Which biomarkers can discriminate different clinical phenotypes?

This topic centers on finding biomarkers for tolerance and clinical allergy, and within the latter, for symptom severity? Accurate phenotyping is of great importance to understand disease mechanisms and develop strategies for personalized treatments.

B4 - What is the mechanism of immunotherapy?

Allergen-specific immunotherapy is the only causal treatment of IgE-mediated allergies. Despite the fact that it has been used for over a century now, its mechanism still is not completely clear. Certainly the topic has overlap with the question what makes healthy subjects tolerant to allergens. Better insight in the mechanism of tolerance induction may help improve strategies for immunotherapy, but also for primary prevention.

Translational questions:

T1 - Can we predict the allergenic risk of proteins?

This topic deals with the question whether it is possible to predict if exposure to novel proteins will pose an increased risk of sensitization and symptom elicitation in an atopic population having established allergies or being prone to develop them. Can we establish a risk profile of a novel protein based on its intrinsic physico-chemical and functional properties and the context of exposure? A reliable evidence –based prediction algorithm would be of great importance for protocols to evaluate the allergenic risk transgene candidates for genetically-modified food crops.

T2 - Can we develop strategies to prevent sensitization?

The longstanding paradigm of prevention by avoidance of exposure to allergens is under serious scrutiny. This development has initially been based on epidemiological observations. High allergen exposure in the first year of life is now slowly gaining support as a better way forward for prevention. This hypothesis needs confirmation in randomized placebo-controlled intervention studies. Also factors linked to the context of exposure to allergens have provided new leads for primary prevention. These factors include the intensity, frequency and chronicity of early childhood infections, gut microbiota composition, dietary composition (vitamins, fatty acids, etc.), environmental co-exposures (non-pathogenic micro-organisms) and (sedentary indoor) life-style. Mechanistic studies (human in vitro and animal models) have to pave the way towards intervention studies.

T3 - How can we improve performance of diagnostic tests?

In vitro diagnostic tests for specific IgE antibodies are used to support the diagnosis of IgE-mediated allergies. These tests have for more than four decades been based on extracts of allergen sources. These tests have always had problems with sensitivity (important allergens under-represented in extracts) and specificity (detection of IgE without clinical relevance). Molecular allergology has now provided the tools to improve this situation. Important allergens can now be produced as recombinant reagents and evaluated for diagnostic purposes. Epidemiological surveys and diagnostic clinical trials are needed to establish which allergens are responsible for which clinical phenotypes. Based on this knowledge, molecular diagnostic tests can be developed to replace extract-based tests.

T4 - How can we improve safety and efficacy of immunotherapy?

As is true for allergy diagnostics, allergen-specific immunotherapy is performed with allergen extracts. This therapy is effective but has a serious risk of (allergic) side-effects. In addition, the current therapy requires 3 to 5 years of monthly injections to achieve its long-lasting effect. The challenge is to make immunotherapy safer and more effective, in particular in the sense of shortening the therapy significantly. Molecular allergology has provided the opportunity to design hypo-allergenic recombinant versions of the most important disease-related proteins, the so-called major allergens. In addition, these molecules can be selected for increased immunogenicity and combined with novel adjuvants that effectively induce protective anti-inflammatory immune skewing. These approaches need to be evaluated in first-in-man clinical trials, and subsequently evaluated for superiority to current treatment, both with respect to safety and efficacy.

The research group of Ronald van Ree works on all of the above described research topics. It does so using four major research disciplines: epidemiological surveys, mouse models, clinical trials and human in vitro immunology.

AMC themes: Infection & Immunity, Public Health & Epidemiology
Departments: Ear, Nose and Throat, Experimental Immunology
Buhler S, Akkerdaas JH, A Pertinhez T, van Ree R, Dossena A, Sforza S, Tedeschi T, Development of a strategy for the total chemical synthesis of an allergenic protein: the peach LTP Pru p 3. J PEPT SCI 2017;ahead of print [PubMed]
Canbaz D, Logiantara A, van Ree R, van Rijt LS, Immunotoxicity of organophosphate flame retardants TPHP and TDCIPP on murine dendritic cells in vitro. CHEMOSPHERE 2017;177:56-64 [PubMed]
Grabenhenrich LB, Reich A, Bellach J, Trendelenburg V, Sprikkelman AB, Roberts G, Grimshaw KEC, Sigurdardottir S, Kowalski ML, Papadopoulos NG, Quirce S, Dubakiene R, Niggemann B, Fernández-Rivas M, Ballmer-Weber B, van Ree R, Schnadt S, Mills ENC, Keil T, Beyer K, A new framework for the documentation and interpretation of oral food challenges in population-based and clinical research. ALLERGY 2017;72 (3):453-461 [PubMed]
Nurmatov U, Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, Du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen LK, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A, Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. ALLERGY 2017;ahead of print [PubMed]
Utsch L, Logiantara A, van Ree R, van Rijt LS, Experimental food allergy to peanut enhances the immune response to house dust mite in the airways of mice. CLIN EXP ALLERGY 2017;47 (1):121-128 [PubMed]
Utsch Mendes Gouveia L. Mouse models of allergic inflammation: from allergic sensitization to immunotherapy. S.l.: s.n.; 2017. 204p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Ree R; copromotor(s): van Rijt LS)
Amaral AFS, Newson RB, Abramson MJ, Antó JM, Bono R, Corsico AG, de Marco R, Demoly P, Forsberg B, Gislason T, Heinrich J, Huerta I, Janson C, Jõgi R, Kim JL, Maldonado J, Martinez-Moratalla Rovira J, Neukirch C, Nowak D, Pin I, Probst-Hensch N, Raherison-Semjen C, Svanes C, Urrutia Landa I, van Ree R, Versteeg SA, Weyler J, Zock JP, Burney PGJ, Jarvis DL, Changes in IgE sensitization and total IgE levels over 20 years of follow-up. J ALLERGY CLIN IMMUN 2016;137 (6):1788-+ [PubMed]
Calderon MA, Demoly P, Casale T, Akdis CA, Bachert C, Bewick M, Bilo BM, Bohle B, Bonini S, Bush A, Caimmi DP, Canonica GW, Cardona V, Chiriac AM, Cox L, Custovic A, de Blay F, Devillier P, Didier A, Di Lorenzo G, du Toit G, Durham SR, Eng P, Fiocchi A, Fox AT, van Wijk RG, Gomez RM, Haathela T, Halken S, Hellings PW, Jacobsen L, Just J, Tanno LK, Kleine-Tebbe J, Klimek L, Knol EF, Kuna P, Larenas-Linnemann DE, Linneberg A, Matricardi M, Malling HJ, Moesges R, Mullol J, Muraro A, Papadopoulos N, Passalacqua G, Pastorello E, Pfaar O, Price D, Rodriguez del Rio P, Rueff R, Samolinski B, Scadding GK, Senti G, Shamji MH, Sheikh A, Sisul JC, Sole D, Sturm GJ, Tabar A, van Ree R, Ventura MT, Vidal C, Varga EM, Worm M, Zuberbier T, Bousquet J, Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies. CLIN TRANSL ALLERGY 2016;6:41
Canbaz D, Lebre MC, Logiantara A, van Ree R, van Rijt LS, Indoor pollutant hexabromocyclododecane enhances house dust mite-induced activation of human monocyte-derived dendritic cells. J IMMUNOTOXICOL 2016;13 (6):810-816 [PubMed]
Canbaz D, Logiantara A, Hamers T, van Ree R, van Rijt LS, Indoor Pollutant Hexabromocyclododecane Has a Modest Immunomodulatory Effect on House Dust Mite Induced Allergic Asthma in Mice. ENVIRON SCI TECHNOL 2016;50 (1):405-411 [PubMed]
Canbaz D, van Velzen MJM, Hallner E, Zwinderman AH, Wickman M, Leonards PEG, van Ree R, van Rijt LS, Exposure to organophosphate and polybrominated diphenyl ether flame retardants via indoor dust and childhood asthma. INDOOR AIR 2016;26 (3):403-413 [PubMed]
Dhami S, Nurmatov U, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, Du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen L, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A, Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review. CLIN TRANSL ALLERGY 2016;6:24 [PubMed]
Fedorova OS, Janse JJ, Ogorodova LM, Fedotova MM, Achterberg RA, Verweij JJ, Fernández-Rivas M, Versteeg SA, Potts J, Minelli C, van Ree R, Burney P, Yazdanbakhsh M, Opisthorchis felineus negatively associates with skin test reactivity in Russia - EuroPrevall-INCO study. ALLERGY 2016;ahead of print [PubMed]
Freidl R, Gstoettner A, Baranyi U, Swoboda I, Stolz F, Focke-Tejkl M, Wekerle T, van Ree R, Valenta R, Linhart B, Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy. J ALLERGY CLIN IMMUN 2016;ahead of print [PubMed]
Gao ZS, Ma YT, Zhou X, Yang ZW, Jia HJ, Gao L, Wu SD, Han LY, Yi XY, Wang HY, Akkerdaas JH, van Ree R, Quantification of Peach Fruit Allergen Lipid Transfer Protein by a Double Monoclonal Antibody-based Sandwich ELISA. FOOD ANAL METHOD 2016;9 (4):823-830
Gao ZS, Zhou X, Yang ZW, Versteeg SA, Gao L, Fu WY, Wang HY, Zhou JY, Akkerdaas JH, van Ree R, IgE-binding potencies of three peach Pru p 1 isoforms. MOL NUTR FOOD RES 2016;60 (11):2457-2466 [PubMed]
Goodman RE, Ebisawa M, Ferreira F, Sampson HA, van Ree R, Vieths S, Baumert JL, Bohle B, Lalithambika S, Wise J, Taylor SL, AllergenOnline: A peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity. MOL NUTR FOOD RES 2016;60 (5):1183-1198 [PubMed]
Himly M, Nandy A, Kahlert H, Thilker M, Steiner M, Briza P, Neubauer A, Klysner S, van Ree R, Buchheit KH, Vieths S, Ferreira F, Standardization of allergen products: 2. Detailed characterization of GMP-produced recombinant Phl p 5.0109 as European Pharmacopoeia reference standard. ALLERGY 2016;71 (4):495-504 [PubMed]
Jongejan L, van Ree R, Poulsen LK, Hypoallergenic molecules for subcutaneous immunotherapy. EXPERT REV CLIN IMMU 2016;12 (1):5-7 [PubMed]
Joshi SS, Barnett B, Doerrer NG, Glenn K, Herman RA, Herouet-Guicheney C, Hunst P, Kough J, Ladics GS, McClain S, Papineni S, Poulsen LK, Rascle JB, Tao AL, van Ree R, Ward J, Bowman CC, Assessment of potential adjuvanticity of Cry proteins. REGUL TOXICOL PHARM 2016;79:149-155 [PubMed]
Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, Cox L, Demoly P, Frew AJ, O'Hehir R, Kleine-Tebbe J, Muraro A, Lack G, Larenas D, Levin M, Martin BL, Nelson H, Pawankar R, Pfaar O, van Ree R, Sampson H, Sublett JL, Sugita K, Du Toit G, Werfel T, Gerth van Wijk R, Zhang L, Akdis M, Akdis CA, International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics. J ALLERGY CLIN IMMUN 2016;137 (2):358-368 [PubMed]
Kaul S, Zimmer J, Dehus O, Costanzo A, Daas A, Buchheit KH, Asturias JA, Barber D, Carnés J, Chapman M, Dayan-Kenigsberg J, Döring S, Führer F, Hanschmann KM, Holzhauser T, Ledesma A, Moingeon P, Nony E, Pini C, Plunkett G, Reese G, Sandberg E, Sander I, Strecker D, Valerio C, van Ree R, Vieths S, Standardization of allergen products: 3. Validation of candidate European Pharmacopoeia standard methods for quantification of major birch allergen Bet v 1. ALLERGY 2016;71 (10):1414-1424 [PubMed]
Mahesh PA, Wong GWK, Ogorodova L, Potts J, Leung TF, Fedorova O, Holla AD, Fernandez-Rivas M, Clare Mills EN, Kummeling I, Versteeg SA, van Ree R, Yazdanbakhsh M, Burney P, Prevalence of food sensitization and probable food allergy among adults in India: the EuroPrevall INCO study. ALLERGY 2016;71 (7):1010-1019 [PubMed]
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, EIgenmann PA, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Mäkelä M, Morisset M, Niederberger V, Nowak-Węgrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M, EAACI Molecular Allergology User's Guide. PEDIAT ALLERG IMM-UK 2016;27 (Suppl. 23):1-250 [PubMed]
Pfaar O, Nell MJ, Boot JD, Versteeg SA, van Ree R, Roger A, Riechelmann H, Sperl A, Oude Elberink HJNG, Diamant Z, Bachert C, A randomized, 5-arm dose finding study with a mite allergoid SCIT in allergic rhinoconjunctivitis patients. ALLERGY 2016;71 (7):967-976 [PubMed]
Pfaar O, van Twuijver E, Boot JD, Opstelten DJE, Klimek L, van Ree R, Diamant Z, Kuna P, Panzner P, A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT-birch pollen extract for the treatment of allergic rhinitis: results of a phase II study. ALLERGY 2016;71 (1):99-107 [PubMed]
Turner PJ, Baumert JL, Beyer K, Boyle RJ, Chan CH, Clark AT, Crevel RWR, DunnGalvin A, Fernández-Rivas M, Gowland MH, Grabenhenrich L, Hardy S, Houben GF, O'B Hourihane J, Muraro A, Poulsen LK, Pyrz K, Remington BC, Schnadt S, van Ree R, Venter C, Worm M, Mills ENC, Roberts G, Ballmer-Weber BK, Can we identify patients at risk of life-threatening allergic reactions to food?. ALLERGY 2016;71 (9):1241-1255 [PubMed]
Utsch L, Logiantara A, Wallner M, Hofer H, van Ree R, van Rijt LS, Birch pollen immunotherapy inhibits anaphylaxis to the cross-reactive apple allergen Mal d 1 in mice. CLIN EXP ALLERGY 2016;46 (11):1474-1483 [PubMed]
van Rijt L, von Richthofen H, van Ree R, Type 2 innate lymphoid cells: at the cross-roads in allergic asthma. SEMIN IMMUNOPATHOL 2016;38 (4):483-496 [PubMed]
Ballmer-Weber BK, Fernandez-Rivas M, Beyer K, Defernez M, Sperrin M, Mackie AR, Salt LJ, Hourihane JOB, Asero R, Belohlavkova S, Kowalski M, de Blay F, Papadopoulos NG, Clausen M, Knulst AC, Roberts G, Popov T, Sprikkelman AB, Dubakiene R, Vieths S, van Ree R, Crevel R, Mills ENC, How much is too much? Threshold dose distributions for 5 food allergens. J ALLERGY CLIN IMMUN 2015;135 (4):964-971 [PubMed]
Ballmer-Weber BK, Lidholm J, Fernández-Rivas M, Seneviratne S, Hanschmann KM, Vogel L, Bures P, Fritsche P, Summers C, Knulst AC, Le TM, Reig I, Papadopoulos NG, Sinaniotis A, Belohlavkova S, Popov T, Kralimarkova T, de Blay F, Purohit A, Clausen M, Jedrzejczak-Czechowcz M, Kowalski ML, Asero R, Dubakiene R, Barreales L, Clare Mills EN, van Ree R, Vieths S, IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study. ALLERGY 2015;70 (4):391-407 [PubMed]
Canbaz D, Utsch L, Logiantara A, van Ree R, van Rijt LS, IL-33 promotes the induction of immunoglobulin production after inhalation of house dust mite extract in mice. ALLERGY 2015;70 (5):522-532 [PubMed]
Datema MR, Zuidmeer-Jongejan L, Asero R, Barreales L, Belohlavkova S, de Blay F, Bures P, Clausen M, Dubakiene R, Gislason D, Jedrzejczak-Czechowicz M, Kowalski ML, Knulst AC, Kralimarkova T, Le TM, Lovegrove A, Marsh J, Papadopoulos NG, Popov T, del Prado N, Purohit A, Reese G, Reig I, Seneviratne SL, Sinaniotis A, Versteeg SA, Vieths S, Zwinderman AH, Mills C, Lidholm J, Hoffmann-Sommergruber K, Fernández-Rivas M, Ballmer-Weber B, van Ree R, Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. J ALLERGY CLIN IMMUN 2015;136 (2):382-391 [PubMed]
Fernández-Rivas M, Barreales L, Mackie AR, Fritsche P, Vázquez-Cortés S, Jedrzejczak-Czechowicz M, Kowalski ML, Clausen M, Gislason D, Sinaniotis A, Kompoti E, Le TM, Knulst AC, Purohit A, de Blay F, Kralimarkova T, Popov T, Asero R, Belohlavkova S, Seneviratne SL, Dubakiene R, Lidholm J, Hoffmann-Sommergruber K, Burney P, Crevel R, Brill M, Fernández-Pérez C, Vieths S, Clare Mills EN, van Ree R, Ballmer-Weber BK, The EuroPrevall outpatient clinic study on food allergy: background and methodology. ALLERGY 2015;70 (5):576-584 [PubMed]
Hamid F, Amoah AS, van Ree R, Yazdanbakhsh M, Helminth-Induced IgE and Protection Against Allergic Disorders. CURR TOP MICROBIOL 2015;388:91-108 [PubMed]
Hamid F, Wahyuni S, van Leeuwen A, van Ree R, Yazdanbakhsh M, Sartono E, Allergic disorders and socio-economic status: a study of schoolchildren in an urban area of Makassar, Indonesia. CLIN EXP ALLERGY 2015;45 (7):1226-1236 [PubMed]
Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, Cox L, Demoly P, Frew AJ, O'Hehir R, Kleine-Tebbe J, Muraro A, Lack G, Larenas D, Levin M, Nelson H, Pawankar R, Pfaar O, van Ree R, Sampson H, Santos AF, Du Toit G, Werfel T, Gerth van Wijk R, Zhang L, Akdis CA, International consensus on allergy immunotherapy. J ALLERGY CLIN IMMUN 2015;136 (3):556-568 [PubMed]
Le TM, van Hoffen E, Kummeling I, Potts J, Ballmer-Weber BK, Bruijnzeel-Koomen CAFM, Lebens AFM, Lidholm J, Lindner TM, Mackie A, Mills ENC, van Ree R, Vieths S, Fernández-Rivas M, Burney PG, Knulst AC, Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients. CLIN TRANSL ALLERGY 2015;5:8 [PubMed]
Masthoff LJ, van Hoffen E, Mattsson L, Lidholm J, Andersson K, Zuidmeer-Jongejan L, Versteeg SA, Bruijnzeel-Koomen CA, Knulst AC, Pasmans SG, van Ree R, Peanut allergy is common among hazelnut-sensitized subjects but is not primarily the result of IgE cross-reactivity. ALLERGY 2015;70 (3):265-274 [PubMed]
Utsch L, Folisi C, Akkerdaas JH, Logiantara A, van de Pol MA, van der Zee JS, Krop EJM, Lutter R, van Ree R, van Rijt LS, Allergic sensitization is associated with inadequate antioxidant responses in mice and men. ALLERGY 2015;70 (10):1246-1258 [PubMed]
van Ree R, Poulsen LK, Wong GW, Ballmer-Weber BK, Gao Z, Jia X, [Food allergy:definitions, prevalence, diagnosis and therapy]. ZHONGHUA YU FANG YI XUE ZA ZHI 2015;49 (1):87-92 [PubMed]
van Rhijn BD, Vlieg-Boerstra BJ, Versteeg SA, Akkerdaas JH, van Ree R, Terreehorst I, Sprikkelman AB, Verheij J, Smout AJPM, Bredenoord AJ, Evaluation of allergen-microarray-guided dietary intervention as treatment of eosinophilic esophagitis. J ALLERGY CLIN IMMUN 2015;136 (4):1095-7.e3 [PubMed]
Wang HY, Gao ZS, Zhou X, Dai Y, Yao W, Zhang XF, Yang ZW, Wu SD, Yu CH, Yang XY, van Ree R, Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients. INT ARCH ALLERGY IMM 2015;167 (3):203-210 [PubMed]
Zuidmeer-Jongejan L, Huber H, Swoboda I, Rigby N, Versteeg SA, Jensen BM, Quaak S, Akkerdaas JH, Blom L, Asturias J, Bindslev-Jensen C, Bernardi ML, Clausen M, Ferrara R, Hauer M, Heyse J, Kopp S, Kowalski ML, Lewandowska-Polak A, Linhart B, Maderegger B, Maillere B, Mari A, Martinez A, Mills ENC, Neubauer A, Nicoletti C, Papadopoulos NG, Portoles A, Ranta-Panula V, Santos-Magadan S, Schnoor HJ, Sigurdardottir ST, Stahl-Skov P, Stavroulakis G, Stegfellner G, Vázquez-Cortés S, Witten M, Stolz F, Poulsen LK, Fernandez-Rivas M, Valenta R, van Ree R, Development of a hypoallergenic recombinant parvalbumin for first-in-man subcutaneous immunotherapy of fish allergy. INT ARCH ALLERGY IMM 2015;166 (1):41-51 [PubMed]
Amoah AS, Boakye DA, van Ree R, Yazdanbakhsh M, Parasitic worms and allergies in childhood: insights from population studies 2008-2013. PEDIAT ALLERG IMM-UK 2014;25 (3):208-217 [PubMed]
Burney PGJ, Potts J, Kummeling I, Mills ENC, Clausen M, Dubakiene R, Barreales L, Fernandez-Perez C, Fernandez-Rivas M, Le TM, Knulst AC, Kowalski ML, Lidholm J, Ballmer-Weber BK, Braun-Fahlander C, Mustakov T, Kralimarkova T, Popov T, Sakellariou A, Papadopoulos NG, Versteeg SA, Zuidmeer L, Akkerdaas JH, Hoffmann-Sommergruber K, van Ree R, The prevalence and distribution of food sensitization in European adults. ALLERGY 2014;69 (3):365-371 [PubMed]
de Silva D, Geromi M, Halken S, Host A, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AEJ, Poulsen LK, van Ree R, Vlieg-Boerstra B, Agache I, Grimshaw K, O'Mahony L, Venter C, Arshad SH, Sheikh A [Contributors: Akdis CA, Alvarez R, Beyer K, Bindslev-Jensen C, Demoly P, Eigenmann P, Fernandez Rivas M, Lack G, Marchisotto MJ, Niggemann B, Nilsson C, Papadopoulos N, Skypala I, Worm M]] , Primary prevention of food allergy in children and adults: systematic review. ALLERGY 2014;69 (5):581-589 [PubMed]
de Silva D, Geromi M, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AEJ, Halken S, Host A, Poulsen LK, van Ree R, Vlieg-Boerstra BJ, Agache I, Sheikh A [Contributors: Akdis CA, Alvarez R, Beyer K, Bindslev-Jensen C, Demoly P, Eigenmann P, Fernandez Rivas M, Lack G, Marchisotto MJ, Niggemann B, Nilsson C, Papadopoulos N, Skypala I, Worm M]] , Acute and long-term management of food allergy: systematic review. ALLERGY 2014;69 (2):159-167 [PubMed]
Dhami S, Panesar SS, Roberts G, Muraro A, Worm M, Bilò MB, Cardona V, Dubois AEJ, DunnGalvin A, Eigenmann P, Fernandez-Rivas M, Halken S, Lack G, Niggemann B, Rueff F, Santos AF, Vlieg-Boerstra B, Zolkipli ZQ, Sheikh A [Contributors: Akdis CA, Bellou A, Bindslev-Jensen C, Brockow K, Clark A, Demoly P, Harada L, Jutel M, Papadopoulos N, Hoffman-Sommergruber K, Poulsen L, Timmermans F, van Ree R]] , Management of anaphylaxis: a systematic review. ALLERGY 2014;69 (2):168-175 [PubMed]
Janse JJ, Wong GWK, Potts J, Ogorodova LM, Fedorova OS, Mahesh PA, Sakellariou A, Papadopoulos NG, Knulst AC, Versteeg SA, Kroes ACM, Vossen ACTM, Campos Ponce M, Kummeling I, Burney P, van Ree R, Yazdanbakhsh M, The association between foodborne and orofecal pathogens and allergic sensitisation -- EuroPrevall study. PEDIAT ALLERG IMM-UK 2014;25 (3):250-256 [PubMed]
Jongejan L, van Ree R, Modified allergens and their potential to treat allergic disease. CURR ALLERGY ASTHM R 2014;14 (12):478 [PubMed]
Klimek L, Sperl A, van Twuijver E, van Ree R, Kleinjans H, Boot JD, Pfaar O, A prospective study comparing the efficacy and safety of two sublingual birch allergen preparations. CLIN TRANSL ALLERGY 2014;4:23 [PubMed]
Koid AE, Chapman MD, Hamilton RG, van Ree R, Versteeg SA, Dreskin SC, Koppelman SJ, Wünschmann S, Ara h 6 complements Ara h 2 as an important marker for IgE reactivity to peanut. J AGR FOOD CHEM 2014;62 (1):206-213 [PubMed]
Ma YT, Zhou X, Gao ZS, Li XW, Jia HJ, Wu HX, Xie RJ, Wang ZQ, Yu ML, Cao K, Chen SJ, Li YH, Wang HY, van Ree R, The PpLTP1 Primary Allergen Gene is Highly Conserved in Peach and Has Small Variations in Other Prunus Species. PLANT MOL BIOL REP 2014;32 (3):652-663
McClain S, Bowman C, Fernández-Rivas M, Ladics GS, van Ree R, Allergic sensitization: food- and protein-related factors. CLIN TRANSL ALLERGY 2014;4 (1):11 [PubMed]
Muraro A, Hoffmann-Sommergruber K, Holzhauser T, Poulsen LK, Gowland MH, Akdis CA, Mills ENC, Papadopoulos N, Roberts G, Schnadt S, van Ree R, Sheikh A, Vieths S, EAACI Food Allergy and Anaphylaxis Guidelines. Protecting consumers with food allergies: understanding food consumption, meeting regulations and identifying unmet needs. ALLERGY 2014;69 (11):1464-1472 [PubMed]
Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, Fernandez Rivas M, Halken S, Hickstein L, Høst A, Knol E, Lack G, Marchisotto MJ, Niggemann B, Nwaru BI, Papadopoulos NG, Poulsen LK, Santos AF, Skypala I, Schoepfer A, van Ree R, Venter C, Worm M, Vlieg-Boerstra B, Panesar S, de Silva D, Soares-Weiser K, Sheikh A, Ballmer-Weber BK, Nilsson C, de Jong NW, Akdis CA, EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. ALLERGY 2014;69 (8):1008-1025 [PubMed]
Newson RB, van Ree R, Forsberg B, Janson C, Lötvall J, Dahlén SE, Toskala EM, Baelum J, Brożek GM, Kasper L, Kowalski ML, Howarth PH, Fokkens WJ, Bachert C, Keil T, Krämer U, Bislimovska J, Gjomarkaj M, Loureiro C, Burney PGJ, Jarvis D, Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA(2) LEN survey. ALLERGY 2014;69 (5):643-651 [PubMed]
Nwaru BI, Hickstein L, Panesar SS, Muraro A, Werfel T, Cardona V, Dubois AEJ, Halken S, Hoffmann-Sommergruber K, Poulsen LK, Roberts G, van Ree R, Vlieg-Boerstra BJ, Sheikh A, The epidemiology of food allergy in Europe: a systematic review and meta-analysis. ALLERGY 2014;69 (1):62-75 [PubMed]
Nwaru BI, Hickstein L, Panesar SS, Roberts G, Muraro A, Sheikh A [Contributors: Halken S, Hoffmann-Sommergruber K, Bindslev-Jensen C, Worm M, Beyer K, Dubois A, Eigenmann P, van Ree R, Poulsen L, Cardona V, Agache I, Papadopoulos N, Akdis C, DuToit G, Monserrat FR, Høst A, Knol E, Lack G, Marchisotto MJ, Niggemann B, Skypala I, Venter ASC, Vlieg-Boerstra B, Ballmer-Weber B, Nilsson C]] , Prevalence of common food allergies in Europe: a systematic review and meta-analysis. ALLERGY 2014;69 (8):992-1007 [PubMed]
Obeng BB, Amoah AS, Larbi IA, de Souza DK, Uh HW, Fernández-Rivas M, van Ree R, Rodrigues LC, Boakye DA, Yazdanbakhsh M, Hartgers FC, Schistosome infection is negatively associated with mite atopy, but not wheeze and asthma in Ghanaian schoolchildren. CLIN EXP ALLERGY 2014;44 (7):965-975 [PubMed]
Poulsen LK, Ladics GS, McClain S, Doerrer NG, van Ree R, Sensitizing properties of proteins: executive summary. CLIN TRANSL ALLERGY 2014;4 (1):10 [PubMed]
Ring J, Akdis C, Lauener R, Schäppi G, Traidl-Hoffmann C, Akdis M, Ammann W, Behrendt H, Bieber T, Biedermann T, Bienenstock J, Blaser K, Braun-Fahrländer C, Brockow K, Buters J, Crameri R, Darsow U, Denburg JA, Eyerich K, Frei R, Galli SJ, Gutermuth J, Holt P, Koren H, Leung D, Müller U, Muraro A, Ollert M, O'Mahony L, Pawankar R, Platts-Mills T, Rhyner C, Rosenwasser LJ, Schmid-Grendelmeier P, Schmidt-Weber CB, Schmutz W, Simon D, Simon HU, Sofiev M, van Hage M, van Ree R, Global Allergy Forum and Second Davos Declaration 2013 Allergy: Barriers to cure--challenges and actions to be taken. ALLERGY 2014;69 (8):978-982 [PubMed]
Smith M, Jäger S, Berger U, Sikoparija B, Hallsdottir M, Sauliene I, Bergmann KC, Pashley CH, de Weger L, Majkowska-Wojciechowska B, Rybníček O, Thibaudon M, Gehrig R, Bonini M, Yankova R, Damialis A, Vokou D, Gutiérrez Bustillo AM, Hoffmann-Sommergruber K, van Ree R, Geographic and temporal variations in pollen exposure across Europe. ALLERGY 2014;69 (7):913-923 [PubMed]
Soares-Weiser K, Takwoingi Y, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Halken S, Poulsen L, van Ree R, Vlieg-Boerstra BJ, Sheikh A, The diagnosis of food allergy: a systematic review and meta-analysis. ALLERGY 2014;69 (1):76-86 [PubMed]
van Ree R. Allergens : Structure and function in: Akdis CA, Agache I, editors. Global atlas of allergy. Zurich: European Academy of Allergy and Clinical Immunology (EAACI); 2014., p. 6-8
van Ree R, Hummelshøj L, Plantinga M, Poulsen LK, Swindle E, Allergic sensitization: host-immune factors. CLIN TRANSL ALLERGY 2014;4 (1):12 [PubMed]
van Rijt LS, Gouveia L, Logiantara A, Canbaz D, Opstelten DJ, van der Kleij HPM, van Ree R, Birch pollen immunotherapy in mice: inhibition of Th2 inflammation is not sufficient to decrease airway hyper-reactivity. INT ARCH ALLERGY IMM 2014;165 (2):128-139 [PubMed]
Zuidmeer-Jongejan L, Fernández-Rivas M, Winter MGT, Akkerdaas JH, Summers C, Lebens A, Knulst AC, Schilte P, Briza P, Gadermaier G, van Ree R, Oil body-associated hazelnut allergens including oleosins are underrepresented in diagnostic extracts but associated with severe symptoms. CLIN TRANSL ALLERGY 2014;4 (1):4 [PubMed]
Amoah AS, Obeng BB, Larbi IA, Versteeg SA, Aryeetey Y, Akkerdaas JH, Zuidmeer L, Lidholm J, Fernández-Rivas M, Hartgers FC, Boakye DA, van Ree R, Yazdanbakhsh M, Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity. J ALLERGY CLIN IMMUN 2013;132 (3):639-647 [PubMed]
Djuardi Y, Supali T, Wibowo H, Kruize YCM, Versteeg SA, van Ree R, Sartono E, Yazdanbakhsh M, The development of TH2 responses from infancy to 4 years of age and atopic sensitization in areas endemic for helminth infections. ALLERGY ASTHMA CL IM 2013;9 (1):13 [PubMed]
Gao ZS, Yang ZW, Wu SD, Wang HY, Liu ML, Mao WL, Wang J, Gadermaier G, Ferreira F, Zheng M, van Ree R, Peach allergy in China: A dominant role for mugwort pollen lipid transfer protein as a primary sensitizer. J ALLERGY CLIN IMMUN 2013;131 (1):224-226 [PubMed]
Hack CE, Relan A, Baboeram A, Oortwijn B, Versteeg S, van Ree R, Pijpstra R, Immunosafety of recombinant human C1-inhibitor in hereditary angioedema: evaluation of ige antibodies. CLIN DRUG INVEST 2013;33 (4):275-281 [PubMed]
Hamid F, Wiria AE, Wammes LJ, Kaisar MMM, Djuardi Y, Versteeg SA, Wahyuni S, van Ree R, Sartono E, Supali T, Yazdanbakhsh M, Risk Factors Associated with the Development of Atopic Sensitization in Indonesia. PLOS ONE 2013;8 (6):e67064 [PubMed]
Kerkvliet E, Sinnige N, Franso C, van Ree R, van den Hout R, Antibody-based assays for potency determination of mite allergoids and for stability studies of alum-adsorbed mite vaccines. ARB PAUL EHRLICH INST BUNDESINSTITUT IMPFSTOFFE BIOMED ARZNEIM LANGEN HESS 2013;97:106-111 [PubMed]
King EM, Filep S, Smith B, Platts-Mills T, Hamilton RG, Schmechel D, Sordillo JE, Milton D, van Ree R, Krop EJM, Heederik DJJ, Metwali N, Thorne PS, Zeldin DC, Sever ML, Calatroni A, Arbes SJ Jr, Mitchell HE, Chapman MD, A multi-center ring trial of allergen analysis using fluorescent multiplex array technology. J IMMUNOL METHODS 2013;387 (1-2):89-95 [PubMed]
Le TM, Bublin M, Breiteneder H, Fernández-Rivas M, Asero R, Ballmer-Weber B, Barreales L, Bures P, Belohlavkova S, de Blay F, Clausen M, Dubakiene R, Gislason D, van Hoffen E, Jedrzejczak-Czechowicz M, Kowalski ML, Kralimarkova T, Lidholm J, Dewitt AM, Mills CEN, Papadopoulos NG, Popov T, Purohit A, van Ree R, Seneviratne S, Sinaniotis A, Summers C, Vázquez-Cortés S, Vieths S, Vogel L, Hoffmann-Sommergruber K, Knulst AC, Kiwifruit allergy across Europe: clinical manifestation and IgE recognition patterns to kiwifruit allergens. J ALLERGY CLIN IMMUN 2013;131 (1):164-171 [PubMed]
Masthoff LJN, Mattsson L, Zuidmeer-Jongejan L, Lidholm J, Andersson K, Akkerdaas JH, Versteeg SA, Garino C, Meijer Y, Kentie P, Versluis A, den Hartog Jager CF, Bruijnzeel-Koomen CAFM, Knulst AC, van Ree R, van Hoffen E, Pasmans SGMA, Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults. J ALLERGY CLIN IMMUN 2013;132 (2):393-399 [PubMed]
Panesar SS, Javad S, de Silva D, Nwaru BI, Hickstein L, Muraro A, Roberts G, Worm M, Bilò MB, Cardona V, Dubois AEJ, Dunn Galvin A, Eigenmann P, Fernandez-Rivas M, Halken S, Lack G, Niggemann B, Santos AF, Vlieg-Boerstra BJ, Zolkipli ZQ, Sheikh A [Contributors: Akdis CA, Bellou A, Bindslev Jensen C, Brockow K, Clark A, Demoly P, Harada L, Hoffman-Sommergruber K, Poulsen L, Rueff F, Jutel M, Papadopoulos N, Timmermans F, van Ree R, Werfel T]] , The epidemiology of anaphylaxis in Europe: a systematic review. ALLERGY 2013;68 (11):1353-1361 [PubMed]
Pfaar O, van Twuijver E, Hecker H, Boot JD, van Ree R, Klimek L, Accelerated up-dosing of subcutaneous immunotherapy with a registered allergoid grass pollen preparation. INT ARCH ALLERGY IMM 2013;160 (4):420-424 [PubMed]
Rieker-Schwienbacher J, Nell MJ, Diamant Z, van Ree R, Distler A, Boot JD, Kleine-Tebbe J, Open-label parallel dose tolerability study of three subcutaneous immunotherapy regimens in house dust mite allergic patients. CLIN TRANSL ALLERGY 2013;3 (1):16 [PubMed]
Tomassen P, Jarvis D, Newson R, van Ree R, Forsberg B, Howarth P, Janson C, Kowalski ML, Krämer U, Matricardi PM, Middelveld RJM, Todo-Bom A, Toskala E, Thilsing T, Brożek G, van Drunen C, Burney P, Bachert C, Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2)LEN study. ALLERGY 2013;68 (10):1289-1297 [PubMed]
van Ree R, Associate Editor Ronald van Ree. INT ARCH ALLERGY IMM 2013;162 (4):273 [PubMed]
van Rhijn BD, van Ree R, Versteeg SA, Vlieg-Boerstra BJ, Sprikkelman AB, Terreehorst I, Smout AJPM, Bredenoord AJ, Birch pollen sensitization with cross-reactivity to food allergens predominates in adults with eosinophilic esophagitis. ALLERGY 2013;68 (11):1475-1481 [PubMed]
Wiria AE, Hamid F, Wammes LJ, Kaisar MMM, May L, Prasetyani MA, Wahyuni S, Djuardi Y, Ariawan I, Wibowo H, Lell B, Sauerwein R, Brice GT, Sutanto I, van Lieshout L, de Craen AJM, van Ree R, Verweij JJ, Tsonaka R, Houwing-Duistermaat JJ, Luty AJF, Sartono E, Supali T, Yazdanbakhsh M, Correction: The Effect of Three-Monthly Albendazole Treatment on Malarial Parasitemia and Allergy: A Household-Based Cluster-Randomized, Double-Blind, Placebo-Controlled Trial. PLOS ONE 2013;8 (9):e57899.correction [PubMed]
Wiria AE, Hamid F, Wammes LJ, Kaisar MMM, May L, Prasetyani MA, Wahyuni S, Djuardi Y, Ariawan I, Wibowo H, Lell B, Sauerwein R, Brice GT, Sutanto I, van Lieshout L, de Craen AJM, van Ree R, Verweij JJ, Tsonaka R, Houwing-Duistermaat JJ, Luty AJF, Sartono E, Supali T, Yazdanbakhsh M, The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. PLOS ONE 2013;8 (3):e57899 [PubMed]
Akkerdaas J, Finkina EI, Balandin SV, Santos Magadán S, Knulst A, Fernandez-Rivas M, Asero R, van Ree R, Ovchinnikova TV, Lentil (Lens culinaris) Lipid Transfer Protein Len c 3: A Novel Legume Allergen. INT ARCH ALLERGY IMM 2012;157 (1):51-57 [PubMed]
van de Pol MA, Lutter R, van Ree R, van der Zee JS, Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics. ALLERGY 2012;67 (1):67-73 [PubMed]
van Rijt LS, Logiantara A, Utsch L, Canbaz D, Boon L, van Ree R, House dust mite allergic airway inflammation facilitates neosensitization to inhaled allergen in mice. ALLERGY 2012;67 (11):1383-1391 [PubMed]
Vieths S, Barber D, Chapman M, Costanzo A, Daas A, Fiebig H, Hanschmann KM, Hrabina M, Kaul S, Ledesma A, Moingeon P, Reese G, Schörner C, van Ree R, Weber B, Buchheit KH, Establishment of recombinant major allergens Bet v 1 and Phl p 5a as Ph. Eur. reference standards and validation of ELISA methods for their measurement. Results from feasibility studies. PHARMEUR BIO SCI NOTES 2012;2012:118-134 [PubMed]
Wang HY, Gao ZS, Yang ZW, Shao JX, Zhao XZ, Dai Y, van Ree R, Anaphylaxis and generalized urticaria from eating Chinese bayberry fruit. J ZHEJIANG UNIV-SC B 2012;13 (10):851-854 [PubMed]
Zuidmeer-Jongejan L, Fernandez-Rivas M, Poulsen LK, Neubauer A, Asturias J, Blom L, Boye J, Bindslev-Jensen C, Clausen M, Ferrara R, Garosi P, Huber H, Jensen BM, Koppelman S, Kowalski ML, Lewandowska-Polak A, Linhart B, Maillere B, Mari A, Martinez A, Mills CE, Nicoletti C, Opstelten DJ, Papadopoulos NG, Portoles A, Rigby N, Scala E, Schnoor HJ, Sigursdottir S, Stavroulakis G, Stolz F, Swoboda I, Valenta R, van den Hout R, Versteeg SA, Witten M, van Ree R, FAST: Towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies. CLIN TRANSL ALLERGY 2012;2 (1):5 [PubMed]
Foetisch K, Dahl L, Jansen B, Becker WM, Lidholm J, van Ree R, Broll H, Kaul S, Vieths S, Holzhauser T, Development and in-house validation of allergen-specific ELISA tests for the quantification of Dau c 1.01, Dau c 1.02 and Dau c 4 in carrot extracts (Daucus carota). ANAL BIOANAL CHEM 2011;399 (2):935-943 [PubMed]
Hamid F, Wiria AE, Wammes LJ, Kaisar MMM, Lell B, Ariawan I, Uh HW, Wibowo H, Djuardi Y, Wahyuni S, Schot R, Verweij JJ, van Ree R, May L, Sartono E, Yazdanbakhsh M, Supali T, A longitudinal study of allergy and intestinal helminth infections in semi urban and rural areas of Flores, Indonesia (ImmunoSPIN Study). BMC INFECT DIS 2011;11 (1):83 [PubMed]
Obeng BB, Amoah AS, Larbi IA, Yazdanbakhsh M, van Ree R, Boakye DA, Hartgers FC, Food Allergy in Ghanaian Schoolchildren: Data on Sensitization and Reported Food Allergy. INT ARCH ALLERGY IMM 2011;155 (1):63-73 [PubMed]
Santos A, van Ree R, Profilins: Mimickers of Allergy or Relevant Allergens?. INT ARCH ALLERGY IMM 2011;155 (3):191-204 [PubMed]
Thijs C, Müller A, Rist L, Kummeling I, Snijders BEP, Huber M, van Ree R, Simões-Wüst AP, Dagnelie PC, van den Brandt PA, Fatty acids in breast milk and development of atopic eczema and allergic sensitisation in infancy. ALLERGY 2011;66 (1):58-67 [PubMed]
van Hoffen E, Peeters KABM, van Neerven RJJ, van der Tas CWH, Zuidmeer L, van Ieperen-van Dijk AG, Bruijnzeel-Koomen CAFM, Knol EF, van Ree R, Knulst AC, Effect of birch pollen-specific immunotherapy on birch pollen-related hazelnut allergy. J ALLERGY CLIN IMMUN 2011;127 (1):100-U176 [PubMed]
Wallner M, Hauser M, Himly M, Zaborsky N, Mutschlechner S, Harrer A, Asam C, Pichler U, van Ree R, Briza P, Thalhamer J, Bohle B, Achatz G, Ferreira F, Reshaping the Bet v 1 fold modulates T-H polarization. J ALLERGY CLIN IMMUN 2011;127 (6):1571-U392 [PubMed]
Yang Z, Ma Y, Chen L, Xie R, Zhang X, Zhang B, Lu M, Wu S, Gilissen LJWJ, van Ree R, Gao Z, Differential transcript abundance and genotypic variation of four putative allergen-encoding gene families in melting peach. TREE GENET GENOMES 2011;7 (5):903-916
Arlorio M, Coisson JD, Bordiga M, Travaglia F, Garino C, Zuidmeer L, van Ree R, Giuffrida MG, Conti A, Martelli A, Olive oil adulterated with hazelnut oils: simulation to identify possible risks to allergic consumers. FOOD ADDIT CONTAM A 2010;27 (1):11-18 [PubMed]
Burney P, Summers C, Chinn S, Hooper R, van Ree R, Lidholm J, Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis. ALLERGY 2010;65 (9):1182-1188 [PubMed]
Garino C, Zuidmeer L, Marsh J, Lovegrove A, Morati M, Versteeg S, Schilte P, Shewry P, Arlorio M, van Ree R, Isolation, cloning, and characterization of the 2S albumin: A new allergen from hazelnut. MOL NUTR FOOD RES 2010;54 (9):1257-1265 [PubMed]
Hogewoning AA, Larbi IA, Addo HA, Amoah AS, Boakye D, Hartgers F, Yazdanbakhsh M, van Ree R, Bouwes Bavinck JN, Lavrijsen APM, Allergic characteristics of urban schoolchildren with atopic eczema in Ghana. J EUR ACAD DERMATOL 2010;24 (12):1406-1412 [PubMed]
Hohlfeld JM, Holland-Letz T, Larbig M, Lavae-Mokhtari M, Wierenga E, Kapsenberg M, van Ree R, Krug N, Bufe A, Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions. CLIN EXP ALLERGY 2010;40 (7):998-1006 [PubMed]
Keil T, McBride D, Grimshaw K, Niggemann B, Xepapadaki P, Zannikos K, Sigurdardottir ST, Clausen M, Reche M, Pascual C, Stanczyk AP, Kowalski ML, Dubakiene R, Drasutiene G, Roberts G, Schoemaker AFA, Sprikkelman AB, Fiocchi A, Martelli A, Dufour S, Hourihane J, Kulig M, Wjst M, Yazdanbakhsh M, Szépfalusi Z, van Ree R, Willich SN, Wahn U, Mills ENC, Beyer K, The multinational birth cohort of EuroPrevall: background, aims and methods. ALLERGY 2010;65 (4):482-490 [PubMed]
Mommers M, Thijs C, Stelma F, Penders J, Reimerink J, van Ree R, Koopmans M, Timing of infection and development of wheeze, eczema, and atopic sensitization during the first 2 yr of life: The KOALA Birth Cohort Study. PEDIAT ALLERG IMM-UK 2010;21 (6):983-989 [PubMed]
Snijders BEP, Stelma FF, Reijmerink NE, Thijs C, van der Steege G, Damoiseaux JGMC, van den Brandt PA, van Ree R, Postma DS, Koppelman GH, CD14 polymorphisms in mother and infant, soluble CD14 in breast milk and atopy development in the infant (KOALA Study). PEDIAT ALLERG IMM-UK 2010;21 (3):541-549 [PubMed]
Supali T, Djuardi Y, Wibowo H, van Ree R, Yazdanbakhsh M, Sartono E, Relationship between Different Species of Helminths and Atopy: A Study in a Population Living in Helminth-Endemic Area in Sulawesi, Indonesia. INT ARCH ALLERGY IMM 2010;153 (4):388-394 [PubMed]
Wong GWK, Mahesh PA, Ogorodova L, Leung TF, Fedorova O, Holla AD, Fernandez-Rivas M, Clare Mills EN, Kummeling I, van Ree R, Yazdanbakhsh M, Burney P, The EuroPrevall-INCO surveys on the prevalence of food allergies in children from China, India and Russia: the study methodology. ALLERGY 2010;65 (3):385-390 [PubMed]
Burtin D, Chabre H, Olagnier B, Didierlaurent A, Couret MN, Comeau D, Wambre E, Laparra H, van Overtvelt L, Montandon F, Batard T, Jonval V, Lorphelin A, Merle C, Berrouet C, Parry L, Gomord V, van Ree R, Moingeon P, Production of native and modified recombinant Der p 1 molecules in tobacco plants. CLIN EXP ALLERGY 2009;39 (5):760-770 [PubMed]
Ganino C. Effect of processing on treenut and fruit allergens. s.l.: s.n.; 2009. 150p. Proefschrift Universita del Piemonte Orientale, Faculty of Medicine. (Promotor(s): Arlorio M; copromotor(s): van Ree R)
Himly M, Nony E, Chabre H, van Overtvelt L, Neubauer A, van Ree R, Buchheit KH, Vieths S, Moingeon P, Ferreira F, Standardization of allergen products: 1. Detailed characterization of GMP-produced recombinant Bet v 1.0101 as biological reference preparation. ALLERGY 2009;64 (7):1038-1045 [PubMed]
Kummeling I, Mills ENC, Clausen M, Dubakiene R, Pérez CF, Fernández-Rivas M, Knulst AC, Kowalski ML, Lidholm J, Le TM, Metzler C, Mustakov T, Popov T, Potts J, van Ree R, Sakellariou A, Töndury B, Tzannis K, Burney P, The EuroPrevall surveys on the prevalence of food allergies in children and adults: background and study methodology. ALLERGY 2009;64 (10):1493-1497 [PubMed]
Oryszczyn MP, van Ree R, Maccario J, Nadif R, Kauffmann F, Cat sensitization according to cat window of exposure in adult asthmatics. CLIN EXP ALLERGY 2009;39 (10):1515-1521 [PubMed]
Reimerink J, Stelma F, Rockx B, Brouwer D, Stobberingh E, van Ree R, Dompeling E, Mommers M, Thijs C, Koopmans M, Early-life rotavirus and norovirus infections in relation to development of atopic manifestation in infants. CLIN EXP ALLERGY 2009;39 (2):254-260 [PubMed]
Reinartz SM, van Ree R, Versteeg SA, Zuidmeer L, van Drunen CM, Fokkens WJ, Diminished response to grass pollen allergen challenge in subjects with concurrent house dust mite allergy. RHINOLOGY 2009;47 (2):192-198 [PubMed]
Boulay A, Houghton J, Gancheva V, Sterk Y, Strada A, Schlegel-Zawadzka M, Sora B, Sala R, van Ree R, Rowe G, A EuroPrevall review of factors affecting incidence of peanut allergy: priorities for research and policy. ALLERGY 2008;63 (7):797-809 [PubMed]
Chapman MD, Ferreira F, Villalba M, Cromwell O, Bryan D, Becker WM, Fernández-Rivas M, Durham S, Vieths S, van Ree R [Contributors: van Ree R, Aalbers M, Notten S, Ooievaar-de Heer P, Ferreira F, Gademaier G, Wallner M, Villalba M, Rodriguez R, Becker WM, Eberhardt F, Lepp U, Raulf-Heimsoth M, Valenta R, Focke M, Bryan D, Dolman C, Das RG, Vieths S, Fötisch K, Di Felice G, Pini C, Cromwell O, Fiebig H, Weber B, van Schijndel H, Dorpema JW, Marco FM, Monsalve R, Barber D, Caldas EF, Moingeon P, Didierlaurent A, André C, Kroon A, Neubauer A, Chapman M, Vailes L, Tsay A, Durham S, Custovic A, Simpson B, Knulst A, Rivas MF, Mancebo EG, Bahima AC, Moncin MMSM, Mari A, Kinaciyan T, Quiralte J, Pauli G, de Blay F, Purohit A, Rak S]] , The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines. J ALLERGY CLIN IMMUN 2008;122 (5):882-889.e2 [PubMed]
Flinterman AE, Akkerdaas JH, den Hartog Jager CF, Rigby NM, Fernandez-Rivas M, Hoekstra MO, Bruijnzeel-Koomen CA, Knulst AC, van Ree R, Pasmans SG, Lipid transfer protein-linked hazelnut allergy in children from a non-Mediterranean birch-endemic area. J ALLERGY CLIN IMMUN 2008;121 (2):423-428.e2 [PubMed]
Flinterman AE, Akkerdaas JH, Knulst AC, van Ree R, Pasmans SG, Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactions. CURR OPIN ALLERGY CL 2008;8 (3):261-265 [PubMed]
Gaier S, Marsh J, Oberhuber C, Rigby NM, Lovegrove A, Alessandri S, Briza P, Radauer C, Zuidmeer L, van Ree R, Hemmer W, Sancho AI, Mills C, Hoffmann-Sommergruber K, Shewry PR, Purification and structural stability of the peach allergens Pru p 1 and Pru p 3. MOL NUTR FOOD RES 2008;52 (Suppl. 2):S220-S229 [PubMed]
Goodman RE, Vieths S, Sampson HA, Hill D, Ebisawa M, Taylor SL, van Ree R, Allergenicity assessment of genetically modified crops--what makes sense?. NAT BIOTECHNOL 2008;26 (1):73-81 [PubMed]
Goodman RE, Vieths S, Sampson HA, Hill D, Ebisawa M, Taylor SL, van Ree R, Erratum: Allergenicity assessment of genetically modified crops-what makes sense?. NAT BIOTECHNOL 2008;26 (2):241 [PubMed]
Hartgers FC, Obeng BB, Kruize YCM, Duijvestein M, de Breij A, Amoah A, Larbi IA, van Ree R, Wilson MD, Rodrigues LC, Boakye DA, Yazdanbakhsh M, Lower Expression of TLR2 and SOCS-3 Is Associated with Schistosoma haematobium Infection and with Lower Risk for Allergic Reactivity in Children Living in a Rural Area in Ghana. PLOS NEGLECT TROP D 2008;2 (4):e227 [PubMed]
Holzhauser T, van Ree R, Poulsen LK, Bannon GA, Analytical criteria for performance characteristics of IgE binding methods for evaluating safety of biotech food products. FOOD CHEM TOXICOL 2008;46 (Suppl. 10):S15-S19 [PubMed]
Kummeling I, Thijs C, Huber M, van de Vijver LPL, Snijders BEP, Penders J, Stelma F, van Ree R, van den Brandt PA, Dagnelie PC, Consumption of organic foods and risk of atopic disease during the first 2 years of life in the Netherlands. BRIT J NUTR 2008;99 (3):598-605 [PubMed]
Mari A, Ooievaar-de Heer P, Scala E, Giani M, Pirrotta L, Zuidmeer L, Bethell D, van Ree R, Evaluation by double-blind placebo-controlled oral challenge of the clinical relevance of IgE antibodies against plant glycans. ALLERGY 2008;63 (7):891-896 [PubMed]
Marsh J, Rigby N, Wellner K, Reese G, Knulst A, Akkerdaas J, van Ree R, Radauer C, Lovegrove A, Sancho A, Mills C, Vieths S, Hoffmann-Sommergruber K, Shewry PR, Purification and characterisation of a panel of peanut allergens suitable for use in allergy diagnosis. MOL NUTR FOOD RES 2008;52 (Suppl. 2):S272-S285 [PubMed]
Oberhuber C, Ma Y, Marsh J, Rigby N, Smole U, Radauer C, Alessandri S, Briza P, Zuidmeer L, Maderegger B, Himly M, Sancho AI, van Ree R, Knulst A, Ebner C, Shewry P, Mills ENC, Wellner K, Breiteneder H, Hoffmann-Sommergruber K, Bublin M, Purification and characterisation of relevant natural and recombinant apple allergens. MOL NUTR FOOD RES 2008;52 (Suppl. 2):S208-S219 [PubMed]
Penders J, Stobberingh EE, van den Brandt PA, van Ree R, Thijs C, Toxigenic and non-toxigenic Clostridium difficile: determinants of intestinal colonisation and role in childhood atopic manifestations. GUT 2008;57 (7):1025-1026 [PubMed]
Rigby NM, Marsh J, Sancho AI, Wellner K, Akkerdaas J, van Ree R, Knulst A, Fernández-Rivas M, Brettlova V, Schilte PP, Summer C, Pumphrey R, Shewry PR, Mills ENC, The purification and characterisation of allergenic hazelnut seed proteins. MOL NUTR FOOD RES 2008;52 (Suppl. 2):S251-S261 [PubMed]
Sancho AI, van Ree R, van Leeuwen A, Meulenbroek BJ, van de Weg EW, Gilissen LJWJ, Puehringer H, Laimer M, Martinelli A, Zaccharini M, Vazquez-Cortes S, Fernandez-Rivas M, Hoffmann-Sommergruber K, Mills ENC, Zuidmeer L, Measurement of lipid transfer protein in 88 apple cultivars. INT ARCH ALLERGY IMM 2008;146 (1):19-26 [PubMed]
Snijders BEP, Thijs C, van Ree R, van den Brandt PA, Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study. PEDIATRICS 2008;122 (1):e115-e122 [PubMed]
van Ree R. Allergen extracts and standardization in: Kay AB, Kaplan AP, Bousquet J, Holt PG, editors. Allergy and allergic diseases. Oxford: Wiley-Blackwell; 2008., p. 928-941
van Ree R, Chapman MD, Ferreira F, Vieths S, Bryan D, Cromwell O, Villalba M, Durham SR, Becker WM, Aalbers M, André C, Barber D, Cistero Bahima A, Custovic A, Didierlaurent A, Dolman C, Dorpema JW, Di Felice G, Eberhardt F, Fernandez Caldas E, Fernandez Rivas M, Fiebig H, Focke M, Fötisch K, Gadermaier G, Das RG, Gonzalez Mancebo E, Himly M, Kinaciyan T, Knulst AC, Kroon AM, Lepp U, Marco FM, Mari A, Moingeon P, Monsalve R, Neubauer A, Notten S, Ooievaar-de Heer P, Pauli G, Pini C, Purohit A, Quiralte J, Rak S, Raulf-Heimsoth M, San Miguel Moncin MM, Simpson B, Tsay A, Vailes L, Wallner M, Weber B, The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification. ALLERGY 2008;63 (3):310-326 [PubMed]
Vieths S, Reese G, Ballmer-Weber BK, Beyer K, Burney P, Fernandez-Rivas M, Summers C, Ree Rv, Mills C, The serum bank of EuroPrevall - the prevalence, cost and basis of food allergy across Europe. FOOD CHEM TOXICOL 2008;46 (Suppl. 10):S12-S14 [PubMed]
Asero R, Ballmer-Weber BK, Beyer K, Conti A, Dubakiene R, Fernandez-Rivas M, Hoffmann-Sommergruber K, Lidholm J, Mustakov T, Oude Elberink JNG, Pumphrey RSH, Stahl Skov P, van Ree R, Vlieg-Boerstra BJ, Hiller R, Hourihane JO, Kowalski M, Papadopoulos NG, Wal JM, Mills ENC, Vieths S, IgE-mediated food allergy diagnosis: Current status and new perspectives. MOL NUTR FOOD RES 2007;51 (1):135-147 [PubMed]
Kummeling I, Stelma FF, Dagnelie PC, Snijders BEP, Penders J, Huber M, van Ree R, van den Brandt PA, Early life exposure to antibiotics and the subsequent development of eczema, wheeze, and allergic sensitization in the first 2 years of life: the KOALA Birth Cohort Study. PEDIATRICS 2007;119 (1):e225-e231 [PubMed]
Lienard D, Tran Dinh O, van Oort E, van Overtvelt L, Bonneau C, Wambre E, Bardor M, Cosette P, Didier-Laurent A, de Borne FD, Delon R, van Ree R, Moingeon P, Faye L, Gomord V, Suspension-cultured BY-2 tobacco cells produce and mature immunologically active house dust mite allergens. PLANT BIOTECHNOL J 2007;5 (1):93-108 [PubMed]
Marknell-Dewitt A. Use of recombinant allergens for component-resolved diagnosis (CRD) in IgE-mediated allergy. s.l.: s.n.; 2007. 60p. ISBN 978-91-554-6861-3 Proefschrift University of Uppsala, Faculty of Medicine. (Promotor(s): Ek P; copromotor(s): van Ree R, Lidholm J)
Mills ENC, Mackie AR, Burney P, Beyer K, Frewer L, Madsen C, Botjes E, Crevel RWR, van Ree R, The prevalence, cost and basis of food allergy across Europe. ALLERGY 2007;62 (7):717-722 [PubMed]
Penders J, Thijs C, van den Brandt PA, Kummeling I, Snijders B, Stelma F, Adams H, van Ree R, Stobberingh EE, Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. GUT 2007;56 (5):661-667 [PubMed]
Purohit A, Shao J, Degreef JM, van Leeuwen A, van Ree R, Pauli G, de Blay F, Role of tropomyosin as a cross-reacting allergen in sensitization to cockroach in patients from Martinique (French Caribbean island) with a respiratory allergy to mite and a food allergy to crab and shrimp. ALLERG IMMUNOL (PARIS) 2007;39 (3):85-88 [PubMed]
Snijders BFP, Thijs C, Dagnelie PC, Stelma FF, Mommers M, Kummeling I, Penders J, van Ree R, van den Brandt PA, Breast-feeding duration and infant atopic manifestations, by maternal allergic status, in the first 2 years of life (KOALA study). J PEDIATR-US 2007;151 (4):347-351 [PubMed]
van Ree R. Cross-reactivity of plant allergens in: Mills C, Wichers H, Hoffmann-Sommergruber K, editors. Managing allergens in food. Cambridge: Woodhead Publishing Ltd.; 2007., p. 83-90
van Ree R, Indoor allergens: relevance of major allergen measurements and standardization. J ALLERGY CLIN IMMUN 2007;119 (2):270-7; quiz 278-9 [PubMed]
van Ree R, Yazdanbakhsh M, Allergic disorders in African countries: linking immunology to accurate phenotype. ALLERGY 2007;62 (3):237-246 [PubMed]
Vassilopoulou EV, Zuidmeer L, Akkerdaas J, Rigby N, Moren FJ, Papadopoulos NG, Saxoni-Papageorgiou P, Milis C, van Ree R, Optimized techniques for the extraction of grape allergens appropriate for in vivo and in vitro testing and diagnosis. MOL NUTR FOOD RES 2007;51 (3):360-366 [PubMed]
Vassilopoulou E, Zuidmeer L, Akkerdaas J, Tassios I, Rigby NR, Mills ENC, van Ree R, Saxoni-Papageorgiou P, Papadopoulos NG, Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome. INT ARCH ALLERGY IMM 2007;143 (2):92-102 [PubMed]
Zuidmeer L, van Ree R, Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. CURR OPIN ALLERGY CL 2007;7 (3):269-273 [PubMed]
Akkerdaas JH, Schocker F, Vieths S, Versteeg S, Zuidmeer L, Hefle SL, Aalberse RC, Richter K, Ferreira F, van Ree R, Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cDNA library. MOL NUTR FOOD RES 2006;50 (1):18-23 [PubMed]
Bakker H, Rouwendal GJA, Karnoup AS, Florack DEA, Stoopen GM, Helsper JPFG, van Ree R, van Die I, Bosch D, An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes. P NATL ACAD SCI USA 2006;103 (20):7577-7582 [PubMed]
Becker WM, van Ree R, Fiebig H, Cromwell O, Weber B, Monsalve R, Barber D, Raulf-Heimsoth M, Moingeon P, Didierlaurent A, di Felice G, Pini C, Fötisch K, Vieths S, Validation of quantitative, allergen-specific ELISAs. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2006;ahead of print [PubMed]
Bohle B, Zwölfer B, Heratizadeh A, Jahn-Schmid B, Antonia YD, Alter M, Keller W, Zuidmeer L, van Ree R, Werfel T, Ebner C, Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo. J ALLERGY CLIN IMMUN 2006;118 (1):242-249 [PubMed]
Bousquet J, Anto JM, Bachert C, Bousquet PJ, Colombo P, Crameri R, Daëron M, Fokkens W, Leynaert B, Lahoz C, Maurer M, Passalacqua G, Valenta R, van Hage M, van Ree R, Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project. ALLERGY 2006;61 (6):671-680 [PubMed]
Fernandez-Rivas M, Aalbers M, Fötisch K, de Heer P, Notten S, Vieths S, van Ree R, Immune reactivity of candidate reference materials. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2006;ahead of print [PubMed]
Fernández-Rivas M, Bolhaar S, González-Mancebo E, Asero R, van Leeuwen A, Bohle B, Ma Y, Ebner C, Rigby N, Sancho AI, Miles S, Zuidmeer L, Knulst A, Breiteneder H, Mills C, Hoffmann-Sommergruber K, van Ree R, Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J ALLERGY CLIN IMMUN 2006;118 (2):481-488 [PubMed]
Ferreira F, Wallner M, Gadermaier G, Erler A, Fritz G, Glatter O, Himly M, Briza P, van Ree R, Physico-chemical characterization of candidate reference materials. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2006;ahead of print [PubMed]
Flinterman AE, Hoekstra MO, Meijer Y, van Ree R, Akkerdaas JH, Bruijnzeel-Koomen CA, Knulst AC, Pasmans SG, Clinical reactivity to hazelnut in children: association with sensitization to birch pollen or nuts?. J ALLERGY CLIN IMMUN 2006;118 (5):1186-1189 [PubMed]
Hermanides HK, Laheÿ-de Boer AM, Zuidmeer L, Guikers C, van Ree R, Knulst AC, Brassica oleracea pollen, a new source of occupational allergens. ALLERGY 2006;61 (4):498-502 [PubMed]
Ma Y, Zuidmeer L, Bohle B, Bolhaar STH, Gadermaier G, Gonzalez-Mancebo E, Fernandez-Rivas M, Knulst AC, Himly M, Asero R, Ebner C, van Ree R, Ferreira F, Breiteneder H, Hoffmann-Sommergruber K, Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. CLIN EXP ALLERGY 2006;36 (8):1087-1096 [PubMed]
Penders J, Stobberingh EE, Thijs C, Adams H, Vink C, van Ree R, van den Brandt PA, Molecular fingerprinting of the intestinal microbiota of infants in whom atopic eczema was or was not developing. CLIN EXP ALLERGY 2006;36 (12):1602-1608 [PubMed]
Punzet M, Ferreira F, Briza P, van Ree R, Malissa H Jr, Stutz H, Profiling preparations of recombinant birch pollen allergen Bet v 1a with capillary zone electrophoresis in pentamine modified fused-silica capillaries. J CHROMATOGR B 2006;839 (1-2):19-29 [PubMed]
Sancho AI, Foxall R, Browne T, dey R, Zuidmeer L, Marzban G, Waldron KW, van Ree R, Hoffmann-Sommergruber K, Laimer M, Mills ENC, Effect of postharvest storage on the expression of the apple allergen Mal d 1. J AGR FOOD CHEM 2006;54 (16):5917-5923 [PubMed]
Sancho AI, Foxall R, Rigby NM, Browne T, Zuidmeer L, van Ree R, Waldron KW, Mills ENC, Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein. J AGR FOOD CHEM 2006;54 (14):5098-5104 [PubMed]
Snijders BEP, Damoiseaux JGMC, Penders J, Kummeling I, Stelma FF, van Ree R, van den Brandt PA, Thijs C, Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study). CLIN EXP ALLERGY 2006;36 (12):1609-1615 [PubMed]
van Ree R, The CREATE project: an introduction. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2006;ahead of print [PubMed]
van Ree R, The CREATE project: future perspectives. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2006;ahead of print [PubMed]
van Ree R, Vieths S, Poulsen LK, Allergen-specific IgE testing in the diagnosis of food allergy and the event of a positive match in the bioinformatics search. MOL NUTR FOOD RES 2006;50 (7):645-654 [PubMed]
Vassilopoulou E, Rigby N, Moreno FJ, Zuidmeer L, Akkerdaas J, Tassios I, Papadopoulos NG, Saxoni-Papageorgiou P, van Ree R, Mills C, Effect of in vitro gastric and duodenal digestion on the allergenicity of grape lipid transfer protein. J ALLERGY CLIN IMMUN 2006;118 (2):473-480 [PubMed]
Zuidmeer L, Salentijn E, Rivas MF, Mancebo EG, Asero R, Matos CI, Pelgrom KTB, Gilissen LJWJ, van Ree R, The role of profilin and lipid transfer protein in strawberry allergy in the Mediterranean area. CLIN EXP ALLERGY 2006;36 (5):666-675 [PubMed]
Zuidmeer L, van Leeuwen WA, Kleine Budde I, Breiteneder H, Ma Y, Mills C, Sancho AI, Meulenbroek EJ, van de Weg E, Gilissen L, Ferreira F, Hoffmann-Sommergruber K, van Ree R, Allergenicity assessment of apple cultivars: hurdles in quantifying labile fruit allergens. INT ARCH ALLERGY IMM 2006;141 (3):230-240 [PubMed]
Akkerdaas JH. Identification and quantification of hazelnut allergens. s.l.: s.n.; 2005. 176p. ISBN 90-6464-243-5 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Aalberse RC; copromotor(s): van Ree R)
Akkerdaas JH, Wensing M, Asero R, Fernandez Rivas M, Rivas MF, Knulst AC, Bolhaar S, Hefle SL, Aalberse RC, van Ree R, IgE binding to pepsin-digested food extracts. INT ARCH ALLERGY IMM 2005;138 (3):203-208 [PubMed]
Ballmer-Weber BK, Wangorsch A, Bohle B, Kaul S, Kündig T, Fötisch K, van Ree R, Vieths S, Component-resolved in vitro diagnosis in carrot allergy: does the use of recombinant carrot allergens improve the reliability of the diagnostic procedure?. CLIN EXP ALLERGY 2005;35 (7):970-978 [PubMed]
Bolhaar STHP, van de Weg WE, van Ree R, Gonzalez-Mancebo E, Zuidmeer L, Bruijnzeel-Koomen CAFM, Fernandez-Rivas M, Jansen J, Hoffmann-Sommergruber K, Knulst AC, Gilissen LJWJ, In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars. J ALLERGY CLIN IMMUN 2005;116 (5):1080-1086 [PubMed]
Bolhaar STHP, van Ree R, Ma Y, Bruijnzeel-Koomen CAFM, Vieths S, Hoffmann-Sommergruber K, Knulst AC, Zuidmeer L, Severe allergy to sharon fruit caused by birch pollen. INT ARCH ALLERGY IMM 2005;136 (1):45-52 [PubMed]
Bolhaar STHP, Zuidmeer L, Ma Y, Ferreira F, Bruijnzeel-Koomen CAFM, Hoffmann-Sommergruber K, van Ree R, Knulst AC, A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge. CLIN EXP ALLERGY 2005;35 (12):1638-1644 [PubMed]
Gilissen LJWJ, Bolhaar STHP, Matos CI, Rouwendal GJA, Boone MJ, Krens FA, Zuidmeer L, van Leeuwen A, Akkerdaas J, Hoffmann-Sommergruber K, Knulst AC, Bosch D, van de Weg WE, van Ree R, Silencing the major apple allergen Mal d 1 by using the RNA interference approach. J ALLERGY CLIN IMMUN 2005;115 (2):364-369 [PubMed]
Goodman RE, Hefle SL, Taylor SL, van Ree R, Assessing genetically modified crops to minimize the risk of increased food allergy: A review. INT ARCH ALLERGY IMM 2005;137 (2):153-166 [PubMed]
Leonard R, Petersen BO, Himly M, Kaar W, Wopfner N, Kolarich D, van Ree R, Ebner C, Duus JØ, Ferreira F, Altmann F, Two novel types of O-glycans on the mugwort pollen allergen Art v 1 and their role in antibody binding. J BIOL CHEM 2005;280 (9):7932-7940 [PubMed]
Sancho AI, Rigby NM, Zuidmeer L, Asero R, Mistrello G, Amato S, González-Mancebo E, Fernández-Rivas M, van Ree R, Mills ENC, The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple, Mal d 3. ALLERGY 2005;60 (10):1262-1268 [PubMed]
van Oort E, Dieker MC, de Heer PG, Peltre G, Aalberse RC, van Ree R, The major grass pollen group 5 allergen from Dactylis glomerata and its C-terminal split product both behave as dimers: Implications for allergen standardization. INT ARCH ALLERGY IMM 2005;136 (2):113-122 [PubMed]
van Ree R, Dorpema JW, Vieths S, Allergy vaccines: a need for standardisation in mass units of major allergen. PHARMEUROPA BIO 2005;2005 (1):27-30 [PubMed]
Wahyuni S, Sartono E, Supali T, van der Zee JS, Mangali A, van Ree R, Houwing-Duistermaat JJ, Yazdanbakhsh M, Clustering of allergic outcomes within families and households in areas endemic for helminth infections. INT ARCH ALLERGY IMM 2005;136 (4):356-364 [PubMed]
Zuidmeer L, van Leeuwen WA, Budde IK, Cornelissen J, Bulder I, Rafalska I, Besolí NT, Akkerdaas JH, Asero R, Fernandez Rivas M, Rivas MF, Gonzalez Mancebo E, Mancebo EG, van Ree R, Lipid transfer proteins from fruit: cloning, expression and quantification. INT ARCH ALLERGY IMM 2005;137 (4):273-281 [PubMed]
Akkerdaas JH, Wensing M, Knulst AC, Stephan O, Hefle SL, Aalberse RC, van Ree R, A novel approach for the detection of potentially hazardous pepsin stable hazelnut proteins as contaminants in chocolate-based food. J AGR FOOD CHEM 2004;52 (25):7726-7731 [PubMed]
Bolhaar STHP, Ree R, Bruijnzeel-Koomen CAFM, Knulst AC, Zuidmeer L, Allergy to jackfruit: a novel example of Bet v 1-related food allergy. ALLERGY 2004;59 (11):1187-1192 [PubMed]
Bolhaar STHP, Tiemessen MM, Zuidmeer L, van Leeuwen A, Hoffmann-Sommergruber K, Bruijnzeel-Koomen CAFM, Taams LS, Knol EF, van Hoffen E, van Ree R, Knulst AC, Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges. CLIN EXP ALLERGY 2004;34 (5):761-769 [PubMed]
Bousquet J, Ansotegui IJ, van Ree R, Burney PG, Zuberbier T, van Cauwenberge P, European Union meets the challenge of the growing importance of allergy and asthma in Europe. ALLERGY 2004;59 (1):1-4 [PubMed]
de Jong NW, Groenewoud GCM, van Ree R, van Leeuwen A, Vermeulen AM, van Toorenenbergen AW, de Groot H, van Wijk RG, Immunoblot and radioallergosorbent test inhibition studies of allergenic cross-reactivity of the predatory mite Amblyseius cucumeris with the house dust mite Dermatophagoides pteronyssinus. ANN ALLERG ASTHMA IM 2004;93 (3):281-287 [PubMed]
Fernández-Rivas M, González-Mancebo E, van Leeuwen WA, León F, van Ree R, Anaphylaxis to raw carrot not linked to pollen allergy. ALLERGY 2004;59 (11):1239-1240 [PubMed]
Mittag D, Akkerdaas J, Ballmer-Weber BK, Vogel L, Wensing M, Becker WM, Koppelman SJ, Knulst AC, Helbling A, Hefle SL, van Ree R, Vieths S, Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy. J ALLERGY CLIN IMMUN 2004;114 (6):1410-1417 [PubMed]
Schocker F, Lüttkopf D, Scheurer S, Petersen A, Cisteró-Bahima A, Enrique E, San Miguel-Moncín M, Akkerdaas J, van Ree R, Vieths S, Becker WM, Recombinant lipid transfer protein Cor a 8 from hazelnut: a new tool for in vitro diagnosis of potentially severe hazelnut allergy. J ALLERGY CLIN IMMUN 2004;113 (1):141-147 [PubMed]
Thomas K, Aalbers M, Bannon GA, Bartels M, Dearman RJ, Esdaile DJ, Fu TJ, Glatt CM, Hadfield N, Hatzos C, Hefle SL, Heylings JR, Goodman RE, Henry B, Herouet C, Holsapple M, Ladics GS, Landry TD, MacIntosh SC, Rice EA, Privalle LS, Steiner HY, Teshima R, van Ree R, Woolhiser M, Zawodny J, A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins. REGUL TOXICOL PHARM 2004;39 (2):87-98 [PubMed]
van den Biggelaar AHJ, Rodrigues LC, van Ree R, van der Zee JS, Hoeksma-Kruize YCM, Souverijn JHM, Missinou MA, Borrmann S, Kremsner PG, Yazdanbakhsh M, Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J INFECT DIS 2004;189 (5):892-900 [PubMed]
van Oort E, de Heer PG, Dieker M, van Leeuwen AW, Aalberse RC, van Ree R, Characterization of natural Dac g 1 variants: An alternative to recombinant group 1 allergens. J ALLERGY CLIN IMMUN 2004;114 (5):1124-1130 [PubMed]
van Oort E, Lerouge P, de Heer PG, Séveno M, Coquet L, Modderman PW, Faye L, Aalberse RC, van Ree R, Substitution of Pichia pastoris-derived recombinant proteins with mannose containing O- and N-linked glycans decreases specificity of diagnostic tests. INT ARCH ALLERGY IMM 2004;135 (3):187-195 [PubMed]
van Ree R, Clinical importance of cross-reactivity in food allergy. CURR OPIN ALLERGY CL 2004;4 (3):235-240 [PubMed]
van Ree R, The CREATE project: EU support for the improvement of allergen standardization in Europe. ALLERGY 2004;59 (6):571-574 [PubMed]
Akkerdaas JH, Wensing M, Knulst AC, Aalberse RC, Hefle SL, van Ree R, In vitro and in vivo characterization of hazelnut skin prick test extracts. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2003;ahead of print [PubMed]
Akkerdaas JH, Wensing M, Knulst AC, Krebitz M, Breiteneder H, de Vries S, Penninks AH, Aalberse RC, Hefle SL, van Ree R, How accurate and safe is the diagnosis of hazelnut allergy by means of commercial skin prick test reagents?. INT ARCH ALLERGY IMM 2003;132 (2):132-140 [PubMed]
Beezhold DH, Hickey VL, Kostyal DA, Puhl H, Zuidmeer L, van Ree R, Sussman GL, Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex protein. ANN ALLERG ASTHMA IM 2003;90 (4):439-445 [PubMed]
Cadot P, Kochuyt AM, van Ree R, Ceuppens JL, Oral allergy syndrome to chicory associated with birch pollen allergy. INT ARCH ALLERGY IMM 2003;131 (1):19-24 [PubMed]
Himly M, Jahn-Schmid B, Dedic A, Kelemen P, Wopfner N, Altmann F, van Ree R, Briza P, Richter K, Ebner C, Ferreira F, Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain. FASEB J 2003;17 (1):106-108 [PubMed]
van Ree R, The CREATE project: a new beginning of allergen standardization based on mass units of major allergens. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2003;ahead of print [PubMed]
van Ree R, Yazdanbakhsh M, Parallels between parasite infections and specific immunotherapy. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2003;ahead of print [PubMed]
Wahyuni S, van Ree R, Mangali A, Supali T, Yazdanbakhsh M, Sartono E, Comparison of an enzyme linked immunosorbent assay (ELISA) and a radioallergosorbent test (RAST) for detection of IgE antibodies to Brugia malayi. PARASITE IMMUNOL 2003;25 (11-12):609-614 [PubMed]
Asero R, Mistrello G, Roncarolo D, Amato S, Caldironi G, Barocci F, van Ree R, Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. ALLERGY 2002;57 (10):900-906 [PubMed]
González EM, Villalba M, Lombardero M, Aalbers M, van Ree R, Rodríguez R, Influence of the 3D-conformation, glycan component and microheterogeneity on the epitope structure of Ole e 1, the major olive allergen - Use of recombinant isoforms and specific monoclonal antibodies as immunological tools. MOL IMMUNOL 2002;39 (1-2):93-101 [PubMed]
Helsper JPFG, Gilissen LJWJ, van Ree R, America AHP, Cordewener JHG, Bosch D, Quadrupole time-of-flight mass spectrometry: a method to study the actual expression of allergen isoforms identified by PCR cloning. J ALLERGY CLIN IMMUN 2002;110 (1):131-138 [PubMed]
van Oort E, de Heer PG, van Leeuwen WA, Derksen NIL, Müller M, Huveneers S, Aalberse RC, van Ree R, Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite. EUR J BIOCHEM 2002;269 (2):671-679 [PubMed]
van Ree R, Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic diseases. INT ARCH ALLERGY IMM 2002;129 (3):189-197 [PubMed]
van Ree R, Clinical importance of non-specific lipid transfer proteins as food allergens. BIOCHEM SOC T 2002;30 (Part 6):910-913 [PubMed]
van Ree R, Isoallergens: a clinically relevant phenomenon or just a product of cloning?. CLIN EXP ALLERGY 2002;32 (7):975-978 [PubMed]
Wensing M, Akkerdaas JH, van Leeuwen WA, Stapel SO, Bruijnzeel-Koomen CAFM, Aalberse RC, Bast BJEG, Knulst AC, van Ree R, IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance. J ALLERGY CLIN IMMUN 2002;110 (3):435-442 [PubMed]
Wensing M, Penninks AH, Hefle SL, Akkerdaas JH, van Ree R, Koppelman SJ, Bruijnzeel-Koomen CAFM, Knulst AC, The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind, placebo-controlled food challenges. CLIN EXP ALLERGY 2002;32 (12):1757-1762 [PubMed]
Wisselink MA, van Ree R, Willemse T, Evaluation of Felis domesticus allergen I as a possible autoallergen in cats with eosinophilic granuloma complex. AM J VET RES 2002;63 (3):338-341 [PubMed]
Wopfner N, Willeroidee M, Hebenstreit D, van Ree R, Aalbers M, Briza P, Thalhamer J, Ebner C, Richter K, Ferreira F, Molecular and immunological characterization of profilin from mugwort pollen. BIOL CHEM 2002;383 (11):1779-1789 [PubMed]
Yazdanbakhsh M, Kremsner PG, van Ree R, Allergy, parasites, and the hygiene hypothesis. SCIENCE 2002;296 (5567):490-494 [PubMed]
Aalberse RC, Akkerdaas J, van Ree R, Cross-reactivity of IgE antibodies to allergens. ALLERGY 2001;56 (6):478-490 [PubMed]
Aalberse RC, Kleine Budde I, Stapel SO, van Ree R, Structural aspects of cross-reactivity and its relation to antibody affinity. ALLERGY 2001;56 (Suppl. 67):27-29 [PubMed]
Asero R, Mistrello G, Roncarolo D, Amato S, van Ree R, A case of allergy to beer showing cross-reactivity between lipid transfer proteins. ANN ALLERG ASTHMA IM 2001;87 (1):65-67 [PubMed]
Asero R, Mistrello G, Roncarolo D, Amato S, van Ree R, String bean-induced anaphylaxis. ALLERGY 2001;56 (3):259-260 [PubMed]
Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier MF, Ciurana CL, Verbeek E, Mohammadi T, Knul-Brettlova V, Akkerdaas JH, Bulder I, Aalberse RC, van Ree R, Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. INT ARCH ALLERGY IMM 2001;124 (1-3):67-69 [PubMed]
van den Biggelaar AH, Lopuhaa C, van Ree R, van der Zee JS, Jans J, Hoek A, Migombet B, Borrmann S, Luckner D, Kremsner PG, Yazdanbakhsh M, The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren. INT ARCH ALLERGY IMM 2001;126 (3):231-238 [PubMed]
van Oort E, de Heer PG, Lerouge P, Faye L, Aalberse RC, van Ree R, Immunochemical characterization of two Pichia pastoris-derived recombinant group 5 Dactylis glomerata isoallergens. INT ARCH ALLERGY IMM 2001;126 (3):196-205 [PubMed]
Aalberse RC, van Ree R, Monoclonal antibody assays for allergens: pick your antibodies with care!. J ALLERGY CLIN IMMUN 2000;106 (4):625-626 [PubMed]
Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier MF, Ciurana CL, Verbeek E, Mohammadi T, Knul-Brettlova V, Akkerdaas JH, Bulder I, Aalberse RC, van Ree R, Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. INT ARCH ALLERGY IMM 2000;122 (1):20-32 [PubMed]
van den Biggelaar AH, van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG, Yazdanbakhsh M, Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. LANCET 2000;356 (9243):1723-1727 [PubMed]
van Ree R, Aalbers M, Kea O, Marco de La Calle FM, Sempere Ortells JM, Villalba M, Rodriguez R, Aalberse RC, A sensitive monoclonal antibody sandwich ELISA for the measurement of the major olive pollen allergen Ole e 1. INT ARCH ALLERGY IMM 2000;122 (3):224-228 [PubMed]
van Ree R, Cabanes-Macheteau M, Akkerdaas J, Milazzo JP, Loutelier-Bourhis C, Rayon C, Villalba M, Koppelman S, Aalberse R, Rodriguez R, Faye L, Lerouge P, Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens. J BIOL CHEM 2000;275 (15):11451-11458 [PubMed]
Aalberse RC, Schuurman J, van Ree R, The apparent monovalency of human IgG4 is due to bispecificity. INT ARCH ALLERGY IMM 1999;118 (2-4):187-189 [PubMed]
Fernández-Rivas M, Brewczynski PZ, Kroon AM, van Ree R, A clinical trial with purified natural major allergens from grass pollen. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 1999;ahead of print [PubMed]
Schuurman J, van Ree R, Perdok GJ, van Doorn HR, Tan KY, Aalberse RC, Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites. IMMUNOLOGY 1999;97 (4):693-698 [PubMed]
van Ree R, A new start for allergen references and standardization based on purified (natural or recombinant) allergens and monoclonal and monospecific polyclonal antibodies. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 1999;ahead of print [PubMed]
van Ree R, Aalberse RC, Specific IgE without clinical allergy. J ALLERGY CLIN IMMUN 1999;103 (6):1000-1001 [PubMed]
van Ree R, van Leeuwen A, Bond J, Aalberse R, Perspective of purified natural and recombinant allergens in diagnosis and treatment of inhalant allergies. INT ARCH ALLERGY IMM 1999;118 (2-4):212-213 [PubMed]
van Ree R, van Leeuwen WA, Akkerdaas JH, Aalberse RC, How far can we simplify in vitro diagnostics for Fagales tree pollen allergy? A study with three whole pollen extracts and purified natural and recombinant allergens. CLIN EXP ALLERGY 1999;29 (6):848-855 [PubMed]
van Ree R, van Leeuwen WA, Bulder I, Bond J, Aalberse RC, Purified natural and recombinant Fel d 1 and cat albumin in in vitro diagnostics for cat allergy. J ALLERGY CLIN IMMUN 1999;104 (6):1223-1230 [PubMed]
Aalberse RC, Stapel SO, van Ree R, Standardization of in vivo and in vitro diagnostic procedures in food allergy. ALLERGY 1998;53 (46 Suppl):62-64 [PubMed]
Hakkaart GA, Aalberse RC, van Ree R, Epitope mapping of the house-dust-mite allergen Der p 2 by means of site-directed mutagenesis. ALLERGY 1998;53 (2):165-172 [PubMed]
Hakkaart GA, Aalberse RC, van Ree R, Involvement of the N-terminus of Der p 2 in IgE and monoclonal antibody binding. INT ARCH ALLERGY IMM 1998;115 (2):150-156 [PubMed]
Hakkaart GA, Chapman MD, Aalberse RC, van Ree R, Immune-reactivity of recombinant isoforms of the major house dust mite allergen Der p 2. CLIN EXP ALLERGY 1998;28 (2):169-174 [PubMed]
Hakkaart GA, Harmsen MM, Chua KY, Thomas WR, Aalberse RC, van Ree R, Expression of the house dust mite allergen Der p 2 in the baker's yeast Saccharomyces cerevisiae. CLIN EXP ALLERGY 1998;28 (1):45-52 [PubMed]
van Ree R, van Leeuwen WA, Aalberse RC, How far can we simplify in vitro diagnostics for grass pollen allergy?: A study with 17 whole pollen extracts and purified natural and recombinant major allergens. J ALLERGY CLIN IMMUN 1998;102 (2):184-190 [PubMed]
Aalberse RC, van Ree R, Crossreactive carbohydrate determinants. CLIN REV ALLERG IMMU 1997;15 (4):375-387 [PubMed]
Fernández-Rivas M, van Ree R, Cuevas M, Allergy to Rosaceae fruits without related pollinosis. J ALLERGY CLIN IMMUN 1997;100 (6 Part 1):728-733 [PubMed]
Hakkaart GA, Aalberse RC, van Ree R, Lack of lysozyme activity of natural and yeast-derived recombinant Der p 2. INT ARCH ALLERGY IMM 1997;114 (2):202-204 [PubMed]
van der Veen MJ, van Ree R, Aalberse RC, Akkerdaas J, Koppelman SJ, Jansen HM, van der Zee JS, Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J ALLERGY CLIN IMMUN 1997;100 (3):327-334 [PubMed]
van Ree R, Analytic aspects of the standardization of allergenic extracts. ALLERGY 1997;52 (8):795-805 [PubMed]
van Ree R, Monoclonal versus monospecific polyclonal antibodies and purified major allergens: their application in allergen standardization. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 1997;ahead of print [PubMed]
van Ree R, van Leeuwen WA, Dieges PH, van Wijk RG, de Jong N, Brewczyski PZ, Kroon AM, Schilte PP, Tan KY, Simon-Licht IF, Roberts AM, Stapel SO, Aalberse RC, Measurement of IgE antibodies against purified grass pollen allergens (Lol p 1, 2, 3 and 5) during immunotherapy. CLIN EXP ALLERGY 1997;27 (1):68-74 [PubMed]
Aalberse RC, van Ree R, Cross-reactive carbohydrate determinants. MONOGR ALLERGY 1996;32:78-83 [PubMed]
Dannemann A, van Ree R, Kulig M, Bergmann RL, Bauer P, Forster J, Guggenmoos-Holzmann I, Aalberse RC, Wahn U, Specific IgE and IgG4 immune responses to tetanus and diphtheria toxoid in atopic and nonatopic children during the first two years of life. INT ARCH ALLERGY IMM 1996;111 (3):262-267 [PubMed]
Hakkaart GA, Aalberse RC, van Ree R, Expression of the house dust mite allergen Der p2 and mutants in the baker's yeast Saccharomyces cerevisiae. ADV EXP MED BIOL 1996;409:395-398 [PubMed]
van der Veen MJ, Mulder M, Witteman AM, van Ree R, Aalberse RC, Jansen HM, van der Zee JS, False-positive skin prick test responses to commercially available dog dander extracts caused by contamination with house dust mite (Dermatophagoides pteronyssinus) allergens. J ALLERGY CLIN IMMUN 1996;98 (6 Part 1):1028-1034 [PubMed]
van Ree R, Antonicelli L, Akkerdaas JH, Garritani MS, Aalberse RC, Bonifazi F, Possible induction of food allergy during mite immunotherapy. ALLERGY 1996;51 (2):108-113 [PubMed]
van Ree R, Antonicelli L, Akkerdaas JH, Pajno GB, Barberio G, Corbetta L, Ferro G, Zambito M, Garritani MS, Aalberse RC, Bonifazi F, Asthma after consumption of snails in house-dust-mite-allergic patients: a case of IgE cross-reactivity. ALLERGY 1996;51 (6):387-393 [PubMed]
Aalberse RC, van Ree R, Danneman A, Wahn U, IgE antibodies to tetanus toxoid in relation to atopy. INT ARCH ALLERGY IMM 1995;107 (1-3):169-171 [PubMed]
Akkerdaas JH, van Ree R, Aalbers M, Stapel SO, Aalberse RC, Multiplicity of cross-reactive epitopes on Bet v I as detected with monoclonal antibodies and human IgE. ALLERGY 1995;50 (3):215-220 [PubMed]
de Maat-Bleeker F, Akkerdaas JH, van Ree R, Aalberse RC, Vineyard snail allergy possibly induced by sensitization to house-dust mite (Dermatophagoides pteronyssinus). ALLERGY 1995;50 (5):438-440 [PubMed]
Pasmans SG, Aalbers M, van Ree R, Knol EF, Jansen HM, Aalberse RC, IgE binding to a human profilin-containing fraction caused by contamination with yeast-derived material. J ALLERGY CLIN IMMUN 1995;96 (5 Part 1):696-697 [PubMed]
van Ree R, Aalberse RC, Demonstration of carbohydrate-specific immunoglobulin G4 antibodies in sera of patients receiving grass pollen immunotherapy. INT ARCH ALLERGY IMM 1995;106 (2):146-148 [PubMed]
van Ree R, Aalberse RC, Rabbit IgG directed to a synthetic C-terminal peptide of the major grass pollen allergen Lol p I inhibits human basophil histamine release induced by natural Lol p I. INT ARCH ALLERGY IMM 1995;106 (3):250-257 [PubMed]
van Ree R, Brewczyński PZ, Tan KY, Mulder-Willems HJ, Widjaja P, Stapel SO, Aalberse RC, Kroon AM, Grass pollen immunotherapy induces highly cross-reactive IgG antibodies to group V allergen from different grass species. ALLERGY 1995;50 (3):281-283 [PubMed]
van Ree R, Fernández-Rivas M, Cuevas M, van Wijngaarden M, Aalberse RC, Pollen-related allergy to peach and apple: an important role for profilin. J ALLERGY CLIN IMMUN 1995;95 (3):726-734 [PubMed]
van Ree R, Hoffman DR, van Dijk W, Brodard V, Mahieu K, Koeleman CA, Grande M, van Leeuwen WA, Aalberse RC, Lol p XI, a new major grass pollen allergen, is a member of a family of soybean trypsin inhibitor-related proteins. J ALLERGY CLIN IMMUN 1995;95 (5 Part 1):970-978 [PubMed]
Yazdanbakhsh M, Paxton WA, Brandenburg A, van Ree R, Lens M, Partono F, Maizels RM, Selkirk ME, Differential antibody isotype reactivity to specific antigens in human lymphatic filariasis: gp15/400 preferentially induces immunoglobulin E (IgE), IgG4, and IgG2. INFECT IMMUN 1995;63 (10):3772-3779 [PubMed]
Grote M, Dolecek C, van Ree R, Valenta R, Immunogold electron microscopic localization of timothy grass (Phleum pratense) pollen major allergens Phl p I and Phl p V after anhydrous fixation in acrolein vapor. J HISTOCHEM CYTOCHEM 1994;42 (3):427-431 [PubMed]
Laffer S, Valenta R, Vrtala S, Susani M, van Ree R, Kraft D, Scheiner O, Duchêne M, Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species. J ALLERGY CLIN IMMUN 1994;94 (4):689-698 [PubMed]
Laffer S, Vrtala S, Duchêne M, van Ree R, Kraft D, Scheiner O, Valenta R, IgE-binding capacity of recombinant timothy grass (Phleum pratense) pollen allergens. J ALLERGY CLIN IMMUN 1994;94 (1):88-94 [PubMed]
van Ree R, Value of monoclonal antibody-based assays: advantages and drawbacks. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 1994;ahead of print [PubMed]
van Ree R, van Leeuwen WA, van den Berg M, Weller HH, Aalberse RC, IgE and IgG cross-reactivity among Lol p I and Lol p II/III. Identification of the C-termini of Lol p I, II, and III as cross-reactive structures. ALLERGY 1994;49 (4):254-261 [PubMed]
Kurniawan A, Yazdanbakhsh M, van Ree R, Aalberse R, Selkirk ME, Partono F, Maizels RM, Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis. J IMMUNOL 1993;150 (9):3941-3950 [PubMed]
Vrtala S, Grote M, Duchêne M, van Ree R, Kraft D, Scheiner O, Valenta R, Properties of tree and grass pollen allergens: reinvestigation of the linkage between solubility and allergenicity. INT ARCH ALLERGY IMM 1993;102 (2):160-169 [PubMed]
Vrtala S, Sperr WR, Reimitzer I, van Ree R, Laffer S, Müller WD, Valent P, Lechner K, Rumpold H, Kraft D, cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl pV allergen. J IMMUNOL 1993;151 (9):4773-4781 [PubMed]
Roberts AM, van Ree R, Cardy SM, Bevan LJ, Walker MR, Recombinant pollen allergens from Dactylis glomerata: preliminary evidence that human IgE cross-reactivity between Dac g II and Lol p I/II is increased following grass pollen immunotherapy. IMMUNOLOGY 1992;76 (3):389-396 [PubMed]
Roberts AM, van Ree R, Emly J, Cardy SM, Rottier MM, Walker MR, N-terminal amino acid sequence homologies of group V grass pollen allergens. INT ARCH ALLERGY IMM 1992;98 (2):178-180 [PubMed]
van Ree R, Driessen MN, van Leeuwen WA, Stapel SO, Aalberse RC, Variability of crossreactivity of IgE antibodies to group I and V allergens in eight grass pollen species. CLIN EXP ALLERGY 1992;22 (6):611-617 [PubMed]
van Ree R, Voitenko V, van Leeuwen WA, Aalberse RC, Profilin is a cross-reactive allergen in pollen and vegetable foods. INT ARCH ALLERGY IMM 1992;98 (2):97-104 [PubMed]
van Ree R, Clemens JG, Aalbers M, Stapel SO, Aalberse RC, Characterization with monoclonal and polyclonal antibodies of a new major allergen from grass pollen in the group I molecular weight range. J ALLERGY CLIN IMMUN 1989;83 (1):144-151 [PubMed]
van Ree R, Stapel SO, Aalberse RC, Reverse-sandwich ELISA may underestimate antibody titers. J ALLERGY CLIN IMMUN 1989;84 (4 Part 1):562-564 [PubMed]
van der Zee JS, Beuvery EC, van Ree R, Aalberse RC, Human IgM antibodies do not activate guinea-pig complement after interaction with soluble antigen. MOL IMMUNOL 1986;23 (6):669-673 [PubMed]
Postma PW, Neyssel OM, van Ree R, Glucose transport in Salmonella typhimurium and Escherichia coli. EUR J BIOCHEM 1982;123 (1):113-119 [PubMed]
Key publications

Gao ZS, Yang ZW, Wu SD, Wang HY, Liu ML, Mao WL, Wang J, Gadermaier G, Ferreira F, Zheng M, van Ree R, Peach allergy in China: A dominant role for mugwort pollen lipid transfer protein as a primary sensitizer. J ALLERGY CLIN IMMUN 2013;131 (1):224-226 [PubMed]
Burney PGJ, Potts J, Kummeling I, Mills ENC, Clausen M, Dubakiene R, Barreales L, Fernandez-Perez C, Fernandez-Rivas M, Le TM, Knulst AC, Kowalski ML, Lidholm J, Ballmer-Weber BK, Braun-Fahlander C, Mustakov T, Kralimarkova T, Popov T, Sakellariou A, Papadopoulos NG, Versteeg SA, Zuidmeer L, Akkerdaas JH, Hoffmann-Sommergruber K, van Ree R, The prevalence and distribution of food sensitization in European adults. ALLERGY 2014;69 (3):365-371 [PubMed]
Datema MR, Zuidmeer-Jongejan L, Asero R, Barreales L, Belohlavkova S, de Blay F, Bures P, Clausen M, Dubakiene R, Gislason D, Jedrzejczak-Czechowicz M, Kowalski ML, Knulst AC, Kralimarkova T, Le TM, Lovegrove A, Marsh J, Papadopoulos NG, Popov T, del Prado N, Purohit A, Reese G, Reig I, Seneviratne SL, Sinaniotis A, Versteeg SA, Vieths S, Zwinderman AH, Mills C, Lidholm J, Hoffmann-Sommergruber K, Fernández-Rivas M, Ballmer-Weber B, van Ree R, Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. J ALLERGY CLIN IMMUN 2015;136 (2):382-391 [PubMed]
Smith M, Jäger S, Berger U, Sikoparija B, Hallsdottir M, Sauliene I, Bergmann KC, Pashley CH, de Weger L, Majkowska-Wojciechowska B, Rybníček O, Thibaudon M, Gehrig R, Bonini M, Yankova R, Damialis A, Vokou D, Gutiérrez Bustillo AM, Hoffmann-Sommergruber K, van Ree R, Geographic and temporal variations in pollen exposure across Europe. ALLERGY 2014;69 (7):913-923 [PubMed]
Santos A, van Ree R, Profilins: Mimickers of Allergy or Relevant Allergens?. INT ARCH ALLERGY IMM 2011;155 (3):191-204 [PubMed]


All Publications

Curriculum Vitae

Ronald van Ree was originally educated in history but switched to biochemistry and immunology, the field in which he defended his thesis at the University of Amsterdam in 1994 on the topic of grass pollen allergens and their interaction with the immune system. From 1994 until 2005 he headed the Allergy Research Laboratory at Sanquin Blood Supply Foundation in Amsterdam. In July 2005 he moved to the Academic Medical Center in Amsterdam where he was appointed as Associate Professor at the Department of Experimental Immunology. There he is head of the Laboratory for Allergy Research. In June 2009 Ronald van Ree was appointed as Full Professor of Molecular and Translational Allergology. The main areas of interest of the Allergy Research group are:

 

 Protein-chemistry and molecular biology of respiratory and food allergens: what makes an allergen an allergen?
 Innovative approaches for in vitro and in vivo diagnosis of IgE-mediated allergy: from allergen extracts to molecular diagnostics.
 Innovative biopharmaceutical approaches for allergen-specific immunotherapy: recombinant technology, novel adjuvants and administration routes.
 Immuno-epidemiology of respiratory and food allergies: the role of allergen exposure, environment, diet, infections and lifestyle in the development of allergy.
 Mouse models of allergy and asthma: how are sensitization and disease expression regulated?

 

Ronald van Ree has participated in many EU Framework Program projects, amongst which as co-ordinator of the CREATE project (FP5) developing certified reference materials for allergen products, as vice-coordinator in the Integrated Project (FP6) on Food Allergy, EuroPrevall, in the GLOFAL project (FP6) aiming at integrating food allergy research in developing countries in EU framework program, as co-ordinator of the ongoing project (FP7) on immunotherapy for food allergy FAST (2008-2015), and more recently as ExCom member of the iFAAM project (FP7) on risk management of food allergy. In February 2014 he has taken up the coordinatorship of a new recently granted EU project BM4SIT targeting at innovative approaches for allergen-specific immunotherapy (novel adjuvant in combination with a designed hypo-allergen). He is on the editorial board of several leading journals in the field of allergology, and is associate editor of International Archives of Allergy and Immunology. He is the academic co-chair of the HESI-PATC. Ronald van Ree has published around 275 papers in peer-reviewed journals, and several book chapters.

Ronald van Ree serves as consultant for HAL Allergy BV (Leiden) and Citeq BV (Groningen)

Research programmes

Molecular mechanisms of disease induction, symptom expression, immunotherpay and prevention in IgE-mediated allergy

The main areas of interets of the Allergy Reserach group are:

  • Protein-chemistry and molecular biology of respiratory and food allergens: what makes an allergen an allergen?
  • Innovative approaches for in vitro and in vivo diagnosis of IgE-mediated allergy: from allergen extracts to molecular diagnostics.
  • Innovative biopharmaceutical approaches for allergen-specific immunotherapy: recombinant technology, novel adjuvants and administration routes.
  • Immuno-epidemiology of respiratory and food allergies: the role of allergen exposure, environment, diet, infections and lifestyle in the development of allergy.
  • Mouse models of allergy and asthma: how are sensitization and disease expression regulated? 


Theme: Infection and Immunity / Public Health and Epidemiology
 

This research group participates in CIA

Faculty
Prof. dr. R. van Ree

Postdocs
Dr. J.H. Akkerdaas
Dr. ir. L.S. van Rijt
Dr. L. Zuidmeer

PhD Students
D. Canbaz MSc
M.R. Datema MSc
Y. van Nes
Drs. H.J.M. Warmenhoven MSc
Z. Gao PhD

Others
A. Logiantara
S. Versteeg

Other research related activities
  • Other, European Academy of Allergy and Clinical Immunology
  • Membership of editorial board / Editorship, ALLERGY
  • Membership of editorial board / Editorship, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
  • Membership of medical or scientific committee, WHO/IUIS, WHO/IUIS Allergen standardization Committee
  • Membership of medical or scientific committee, WHO/IUIS, WHO/IUIS Allergen Nomenclature Committee
  • Contribution to guidelines and protocols, Food Allergy and Anaphylaxis Guidelines / European Academy of Allergy and Clinical Immunology
  • Membership of advisory board / Consultant, HAL Allergy
  • Membership of medical or scientific committee, HESI-ILSI, Protein Allergenicity Technical Committee (co-chair)
Current research funding
  • AMC
  • Citeq B.V.
  • Europese Unie
  • HAL Allergy bv
  • NWO