• Male

Prof. dr. G.R. van den Brink MD PhD

Position: Professor
Main activities: Research, Patient care
Specialisation: Gastroenterology & Hepatology, Oncology, Immunology
foto
Focus of research:

The research in my group focusses on two research lines:

1. Understanding of the mechanisms that maintain a healthy colonic epithelium and the way these are deregulated during development of colorectal cancer.  

2. Mechanism of action of drugs used in patients with inflammatory bowel disease and the adaptation of existing successful therapies to achieve reduced side effects and enhanced efficacy. 

AMC themes: Infection & Immunity, Metabolic disorders and gastrointestinal diseases
Departments: Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research
Bloemendaal FM, Levin AD, Wildenberg ME, Koelink PJ, Mcrae BL, Salfeld J, Lum J, van der Neut Kolfschoten M, Claassens JW, Visser R, Bentlage A, D'Haens GRAM, Verbeek JS, Vidarsson G, van den Brink GR, Anti-Tumor Necrosis Factor With a Glyco-Engineered Fc-Region Has Increased Efficacy in Mice With Colitis. GASTROENTEROLOGY 2017;153 (5):1351-+ [PubMed]
Bokun T, van den Brink GR, Young GI Angle: How to apply for a grant. UNITED EUR GASTROENT 2017;5 (1):142-143 [PubMed]
Brandse JF, Mould D, Smeekes O, Ashruf Y, Kuin S, Strik A, van den Brink GR, Dʼhaens GR, A Real-life Population Pharmacokinetic Study Reveals Factors Associated with Clearance and Immunogenicity of Infliximab in Inflammatory Bowel Disease. INFLAMM BOWEL DIS 2017;23 (4):650-660 [PubMed]
Doorenspleet ME , Westera L, Peters CP, Hakvoort TBM, Esveldt RE, Vogels E, van Kampen AHC, Baas F, Buskens C, Bemelman WA, D'Haens G, Ponsioen CY, te Velde AA, de Vries N, van den Brink GR, Profoundly Expanded T-cell Clones in the Inflamed and Uninflamed Intestine of Patients With Crohn's Disease. J CROHNS COLITIS 2017;11 (7):831-839 [PubMed]
Sahami S. New concepts in ulcerative colitis: A thin line between medicine and surgery. S.l.: s.n.; 2017. 244p. ISBN 9789462336230 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bemelman WA; copromotor(s): D'Haens GRAM, van den Brink GR, Buskens CJ)
Sahami S, Buskens CJ, van den Brink GR, D'Haens GR, Bemelman WA, Pathogenesis and Carcinogenesis of the Appendix in Ulcerative Colitis Reply. AM J GASTROENTEROL 2017;112 (1):184-185 [PubMed]
Sahami S, Konté K, Buskens CJ, Tanis PJ, Löwenberg M, Ponsioen CJ, van den Brink GR, Bemelman WA, D'Haens GR, Risk factors for proximal disease extension and colectomy in left-sided ulcerative colitis. UNITED EUR GASTROENT 2017;5 (4):554-562 [PubMed]
Strik AS, van den Brink GR, Ponsioen C, Mathot R, Löwenberg M, D'Haens GR, Suppression of anti-drug antibodies to infliximab or adalimumab with the addition of an immunomodulator in patients with inflammatory bowel disease. ALIMENT PHARM THER 2017;45 (8):1128-1134 [PubMed]
van Gennep S, Sahami S, Buskens CJ, van den Brink GR, Ponsioen CY, D'Hoore A, de Buck van Overstraeten A, van Assche G, Ferrante M, Vermeire S, Bemelman WA, D'Haens GRAM, Löwenberg M, Comparison of health-related quality of life and disability in ulcerative colitis patients following restorative proctocolectomy with ileal pouch-anal anastomosis versus anti-tumor necrosis factor therapy. EUR J GASTROEN HEPAT 2017;29 (3):338-344 [PubMed]
van Lidth de Jeude JF, Meijer BJ, Wielenga MCB , Spaan CN, Baan B, Rosekrans SL, Meisner S, Shen YH, Lee AS, Paton JC, Paton AW, Muncan V, van den Brink GR, Heijmans J, Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells. ONCOGENE 2017;36 (24):3397-3405 [PubMed]
Westera L, van Viegen T, Jeyarajah J, Azad A, Bilsborough J, van den Brink GR, Cremer J, Danese S, D'Haens G, Eckmann L, Faubion W, Filice M, Korf H, McGovern D, Panes J, Salas A, Sandborn WJ, Silverberg MS, Smith MI, Vermeire S, Vetrano S, Shackelton LM, Stitt L, Jairath V, Levesque BG, Spencer DM, Feagan BG, Vande Casteele N, Centrally Determined Standardization of Flow Cytometry Methods Reduces Interlaboratory Variation in a Prospective Multicenter Study. CLIN TRANSL GASTROEN 2017;8 (11):e126 [PubMed]
Wildenberg ME, Koelink PJ, Diederen K, te Velde AA, Wolfkamp SCS, Nuij VJ, Peppelenbosch MP, Nobis M, Sansom OJ, Anderson KI, van der Woude CJ, D'Haens GRAM, van den Brink GR, The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. MUCOSAL IMMUNOL 2017;10 (2):352-360 [PubMed]
Wildenberg ME, Levin AD, Ceroni A, Guo Z, Koelink PJ, Hakvoort TBM, Westera L, Bloemendaal FM, Brandse JF, Simmons A, D'Haens GR, Ebner D, van den Brink GR, Benzimidazoles promote anti-TNF mediated induction of regulatory macrophages and enhance therapeutic efficacy in a murine model. J CROHNS COLITIS 2017;ahead of print [PubMed]
Brandse JF, Bennink RJ, van Eeden S, Löwenberg M, van den Brink GR, Dʼhaens GR, Performance of Common Disease Activity Markers as a Reflection of Inflammatory Burden in Ulcerative Colitis. INFLAMM BOWEL DIS 2016;22 (6):1384-1390 [PubMed]
Brandse JF, Mathôt RA, van der Kleij D, Rispens T, Ashruf Y, Jansen JM, Rietdijk S, Löwenberg M, Ponsioen CY, Singh S, van den Brink GR, D'Haens GR, Pharmacokinetic Features and Presence of Antidrug Antibodies Associate With Response to Infliximab Induction Therapy in Patients With Moderate to Severe Ulcerative Colitis. CLIN GASTROENTEROL H 2016;14 (2):251-8.e1-2 [PubMed]
Colak S. Targeting cancer stem cells: Modulating apoptosis and stemness. S.l.: s.n.; 2016. 235p. ISBN 978-94-028-0195-8 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Medema JP; copromotor(s): van den Brink GR)
Duijvis NW , ten Hove AS, Ponsioen CIJ, van den Brink GR, Buskens CJ, Bemelman WA, te Velde AA, D'Haens GRAM, Löwenberg M, Similar Short- and Long-term Colectomy Rates with Ciclosporin and Infliximab Treatment in Hospitalised Ulcerative Colitis Patients. J CROHNS COLITIS 2016;10 (7):821-827 [PubMed]
Gardenbroek TJ, Pinkney TD, Sahami S, Morton DG, Buskens CJ, Ponsioen CY, Tanis PJ, Löwenberg M, van den Brink GR, Broeders IAMJ, Pullens HJM, Seerden T, Boom MJ, Mallant-Hent RC, Pierik REGJM, Vecht J, Sosef MN, van Nunen AB, van Wagensveld BA, Stokkers PCF, Gerhards MF, Jansen JM, Acherman Y, Depla ACTM, Mannaerts GHH, West R, Iqbal T, Pathmakanthan S, Howard R, Magill L, Singh B, Oo YH, Negpodiev D, Dijkgraaf MGW, D'Haens GRAM, Bemelman WA, Erratum to: The ACCURE-trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicenter trial (NTR2883) and the ACCURE-UK trial: a randomised external pilot trial (ISRCTN56523019). BMC SURG 2016;16 (1):1 [PubMed]
Gecse KB, Sebastian S, Hertogh Gd, Yassin NA, Kotze PG, Reinisch W, Spinelli A, Koutroubakis IE, Katsanos KH, Hart A, van den Brink GR, Rogler G, Bemelman WA, Results of the Fifth Scientific Workshop of the ECCO [II]: Clinical Aspects of Perianal Fistulising Crohn's Disease-the Unmet Needs. J CROHNS COLITIS 2016;10 (7):758-765 [PubMed]
Gerling M, Büller NVJA, Kirn LM, Joost S, Frings O, Englert B, Bergström Å, Kuiper RV, Blaas L, Wielenga MCB, Almer S, Kühl AA, Fredlund E, van den Brink GR, Toftgård R, Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth. NAT COMMUN 2016;7:12321 [PubMed]
Gerling M, Büller NVJA, Kirn LM, Joost S, Frings O, Englert B, Bergström Å, Kuiper RV, Blaas L, Wielenga MCB, Almer S, Kühl AA, Fredlund E, van den Brink GR, Toftgård R, Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth (vol 7, 12321, 2016). NAT COMMUN 2016;7:12936 [PubMed]
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RCC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SSL, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CHA, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RCBQ, de la Fuente J, de Martino L, de Matteis A, de Meyer GR, de Milito A, de Santi M, de Souza W, de Tata V, de Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, del Bello B, del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM Jr, Doran KS, D'Orazi G, Dorn GW 2nd, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA Jr, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM Jr, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÅB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, Harris AL, Harris J, Hasler U, Hasselblatt P, Hasui K, Hawley RG, Hawley TS, He C, He CY, He F, He G, He RR, He XH, He YW, He YY, Heath JK, Hébert MJ, Heinzen RA, Helgason GV, Hensel M, Henske EP, Her C, Herman PK, Hernández A, Hernandez C, Hernández-Tiedra S, Hetz C, Hiesinger PR, Higaki K, Hilfiker S, Hill BG, Hill JA, Hill WD, Hino K, Hofius D, Hofman P, Höglinger GU, Höhfeld J, Holz MK, Hong Y, Hood DA, Hoozemans JJ, Hoppe T, Hsu C, Hsu CY, Hsu LC, Hu D, Hu G, Hu HM, Hu H, Hu MC, Hu YC, Hu ZW, Hua F, Hua Y, Huang C, Huang HL, Huang KH, Huang KY, Huang S, Huang S, Huang WP, Huang YR, Huang Y, Huang Y, Huber TB, Huebbe P, Huh WK, Hulmi JJ, Hur GM, Hurley JH, Husak Z, Hussain SN, Hussain S, Hwang JJ, Hwang S, Hwang TI, Ichihara A, Imai Y, Imbriano C, Inomata M, Into T, Iovane V, Iovanna JL, Iozzo RV, Ip NY, Irazoqui JE, Iribarren P, Isaka Y, Isakovic AJ, Ischiropoulos H, Isenberg JS, Ishaq M, Ishida H, Ishii I, Ishmael JE, Isidoro C, Isobe Ki, Isono E, Issazadeh-Navikas S, Itahana K, Itakura E, Ivanov AI, Iyer AKV, Izquierdo JM, Izumi Y, Izzo V, Jäättelä M, Jaber N, Jackson DJ, Jackson WT, Jacob TG, Jacques TS, Jagannath C, Jain A, Jana NR, Jang BK, Jani A, Janji B, Jannig PR, Jansson PJ, Jean S, Jendrach M, Jeon JH, Jessen N, Jeung EB, Jia K, Jia L, Jiang H, Jiang H, Jiang L, Jiang T, Jiang X, Jiang X, Jiang Y, Jiang Y, Jiménez A, Jin C, Jin H, Jin L, Jin M, Jin S, Jinwal UK, Jo EK, Johansen T, Johnson DE, Johnson GV, Johnson JD, Jonasch E, Jones C, Joosten LA, Jordan J, Joseph AM, Joseph B, Joubert AM, Ju D, Ju J, Juan HF, Juenemann K, Juhász G, Jung HS, Jung JU, Jung YK, Jungbluth H, Justice MJ, Jutten B, Kaakoush NO, Kaarniranta K, Kaasik A, Kabuta T, Kaeffer B, Kågedal K, Kahana A, Kajimura S, Kakhlon O, Kalia M, Kalvakolanu DV, Kamada Y, Kambas K, Kaminskyy VO, Kampinga HH, Kandouz M, Kang C, Kang R, Kang TC, Kanki T, Kanneganti TD, Kanno H, Kanthasamy AG, Kantorow M, Kaparakis-Liaskos M, Kapuy O, Karantza V, Karim MR, Karmakar P, Kaser A, Kaushik S, Kawula T, Kaynar AM, Ke PY, Ke ZJ, Kehrl JH, Keller KE, Kemper JK, Kenworthy AK, Kepp O, Kern A, Kesari S, Kessel D, Ketteler R, Kettelhut IdC, Khambu B, Khan MM, Khandelwal VK, Khare S, Kiang JG, Kiger AA, Kihara A, Kim AL, Kim CH, Kim DR, Kim DH, Kim EK, Kim HY, Kim HR, Kim JS, Kim JH, Kim JC, Kim JH, Kim KW, Kim MD, Kim MM, Kim PK, Kim SW, Kim SY, Kim YS, Kim Y, Kimchi A, Kimmelman AC, Kimura T, King JS, Kirkegaard K, Kirkin V, Kirshenbaum LA, Kishi S, Kitajima Y, Kitamoto K, Kitaoka Y, Kitazato K, Kley RA, Klimecki WT, Klinkenberg M, Klucken J, Knævelsrud H, Knecht E, Knuppertz L, Ko JL, Kobayashi S, Koch JC, Koechlin-Ramonatxo C, Koenig U, Koh YH, Köhler K, Kohlwein SD, Koike M, Komatsu M, Kominami E, Kong D, Kong HJ, Konstantakou EG, Kopp BT, Korcsmaros T, Korhonen L, Korolchuk VI, Koshkina NV, Kou Y, Koukourakis MI, Koumenis C, Kovács AL, Kovács T, Kovacs WJ, Koya D, Kraft C, Krainc D, Kramer H, Kravic-Stevovic T, Krek W, Kretz-Remy C, Krick R, Krishnamurthy M, Kriston-Vizi J, Kroemer G, Kruer MC, Kruger R, Ktistakis NT, Kuchitsu K, Kuhn C, Kumar AP, Kumar A, Kumar A, Kumar D, Kumar D, Kumar R, Kumar S, Kundu M, Kung HJ, Kuno A, Kuo SH, Kuret J, Kurz T, Kwok T, Kwon TK, Kwon YT, Kyrmizi I, La Spada AR, Lafont F, Lahm T, Lakkaraju A, Lam T, Lamark T, Lancel S, Landowski TH, Lane DJR, Lane JD, Lanzi C, Lapaquette P, Lapierre LR, Laporte J, Laukkarinen J, Laurie GW, Lavandero S, Lavie L, LaVoie MJ, Law BYK, Law HKW, Law KB, Layfield R, Lazo PA, Le Cam L, Le Roch KG, Le Stunff H, Leardkamolkarn V, Lecuit M, Lee BH, Lee CH, Lee EF, Lee GM, Lee HJ, Lee H, Lee JK, Lee J, Lee JH, Lee JH, Lee M, Lee MS, Lee PJ, Lee SW, Lee SJ, Lee SJ, Lee SY, Lee SH, Lee SS, Lee SJ, Lee S, Lee YR, Lee YJ, Lee YH, Leeuwenburgh C, Lefort S, Legouis R, Lei J, Lei QY, Leib DA, Leibowitz G, Lekli I, Lemaire SD, Lemasters JJ, Lemberg MK, Lemoine A, Leng S, Lenz G, Lenzi P, Lerman LO, Lettieri Barbato D, Leu JIJ, Leung HY, Levine B, Lewis PA, Lezoualc'h F, Li C, Li F, Li FJ, Li J, Li K, Li L, Li M, 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Kuin S, Stolte SB, van den Brink GR, Ponsioen CY, Fockens P, D'Haens GR, Löwenberg M, Short article: Remicade infusions at home: an alternative setting of infliximab therapy for patients with Crohn's disease. EUR J GASTROEN HEPAT 2016;28 (2):222-225 [PubMed]
Levin AD, Koelink PJ, Bloemendaal FM, Vos ACW, D'Haens GR, van den Brink GR, Wildenberg ME, Autophagy Contributes to the Induction of Anti-TNF Induced Macrophages. J CROHNS COLITIS 2016;10 (3):323-329 [PubMed]
Levin AD, Wildenberg ME, van den Brink GR, Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease. J CROHNS COLITIS 2016;10 (8):989-997 [PubMed]
Mcrae BL, Levin AD, Wildenberg ME, Koelink PJ, Bousquet P, Mikaelian I, Sterman AS, Bryant S, D'Haens G, Kamath R, Salfeld J, van den Brink GR, Fc Receptor-mediated Effector Function Contributes to the Therapeutic Response of Anti-TNF Monoclonal Antibodies in a Mouse Model of Inflammatory Bowel Disease. J CROHNS COLITIS 2016;10 (1):69-76 [PubMed]
Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S, Epithelial calcineurin controls microbiota-dependent intestinal tumor development. NAT MED 2016;22 (5):506-515 [PubMed]
Sahami S, Kooij IA, Meijer SL, van den Brink GR, Buskens CJ, te Velde AA, The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms. AM J GASTROENTEROL 2016;111 (2):163-169 [PubMed]
Samaan MA, de Jong D, Sahami S, Morgan S, Fragkos K, Subramaniam S, Kok K, Makanyanga J, Barnova I, Saravanapavan H, Parisi I, Di Caro S, Vega R, Rahman F, McCartney S, Bloom SL, van den Brink GR, Löwenberg M, Ponsioen CY, Buskens CJ, Tanis PJ, de Buck van Overstraeten A, DʼHoore A, Bemelman WA, Dʼhaens GR, Incidence and Severity of Prepouch Ileitis: A Distinct Disease Entity or a Manifestation of Refractory Pouchitis?. INFLAMM BOWEL DIS 2016;22 (3):662-668 [PubMed]
Schilderink R, Verseijden C, Seppen J, Muncan V , van den Brink GR, Lambers TT, van Tol EA, de Jonge WJ, The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC. AM J PHYSIOL-GASTR L 2016;310 (11):G1138-G1146 [PubMed]
Turfkruyer M, Rekima A, Macchiaverni P, Le Bourhis L, Muncan V, van den Brink GR, Tulic MK, Verhasselt V, Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency. MUCOSAL IMMUNOL 2016;9 (2):479-491 [PubMed]
Wildenberg ME, van den Brink GR, House dust mite: a new player in intestinal inflammation?. GUT 2016;65 (5):727-728 [PubMed]
Brandse JF. Optimizing anti-TNF therapy in inflammatory bowel disease. S.l.: s.n.; 2015. 195p. ISBN 978-94-6259-943-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): D'Haens GRAM, van den Brink GR; copromotor(s): )
Brandse JF, van den Brink GR, Wildenberg ME, van der Kleij D, Rispens T, Jansen JM, Mathôt RA, Ponsioen CY, Löwenberg M, D'Haens GRAM, Loss of Infliximab Into Feces Is Associated With Lack of Response to Therapy in Patients With Severe Ulcerative Colitis. GASTROENTEROLOGY 2015;149 (2):350-5.e2 [PubMed]
Brandse JF, Vos LMC, Jansen J, Schakel T, Ponsioen CIJ, van den Brink GR, D'Haens GR, Löwenberg M, Serum Concentration of Anti-TNF Antibodies, Adverse Effects and Quality of Life in Patients with Inflammatory Bowel Disease in Remission on Maintenance Treatment. J CROHNS COLITIS 2015;9 (11):973-981 [PubMed]
Büller NVJA. Intestinal Hedgehog signaling in tumors and inflammation. S.l.: s.n.; 2015. 162p. ISBN 978-94-6259-629-0 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van den Brink GR; copromotor(s): Muncan V, Wildenberg ME)
Büller NVJA, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JLM, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GRAM, Wildenberg ME, de Sauvage FJ, Muncan V , van den Brink GR, Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice. GASTROENTEROLOGY 2015;148 (1):170-180.e6 [PubMed]
de Bruyn JR, Meijer SL, Wildenberg ME, Bemelman WA, van den Brink GR, D'Haens GR, Development of Fibrosis in Acute and Longstanding Ulcerative Colitis. J CROHNS COLITIS 2015;9 (11):966-972 [PubMed]
D'Haens G, Löwenberg M, Samaan MA, Franchimont D, Ponsioen C, van den Brink GR, Fockens P, Bossuyt P, Amininejad L, Rajamannar G, Lensink EM, van Gossum AM, Safety and Feasibility of Using the Second-Generation Pillcam Colon Capsule to Assess Active Colonic Crohn's Disease. CLIN GASTROENTEROL H 2015;13 (8):1480-6.e3 [PubMed]
Gardenbroek TJ, Pinkney TD, Sahami S, Morton DG, Buskens CJ, Ponsioen CY, Tanis PJ, Löwenberg M, van den Brink GR, Broeders IAMJ, Pullens HJM, Pullens PHJM, Seerden T, Boom MJ, Mallant-Hent RC, Pierik REGJM, Vecht J, Sosef MN, van Nunen AB, van Wagensveld BA, Stokkers PCF, Gerhards MF, Jansen JM, Acherman Y, Depla ACTM, Mannaerts GHH, West R, Iqbal T, Pathmakanthan S, Howard R, Magill L, Singh B, Oo YH, Htun Oo Y, Negpodiev D, Dijkgraaf MGW, D'Haens GRAM, Bemelman WA, The ACCURE-trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicenter trial (NTR2883) and the ACCURE-UK trial: a randomised external pilot trial (ISRCTN56523019). BMC SURG 2015;15 (1):30 [PubMed]
Gecse KB, Brandse JF, van Wilpe S, Löwenberg M, Ponsioen C, van den Brink G, D'Haens G, Impact of disease location on fecal calprotectin levels in Crohn's disease. SCAND J GASTROENTERO 2015;50 (7):841-847 [PubMed]
Rosekrans SL. Homeostasis of the esophageal epithelium: A quest for the stem cell. S.l.: s.n.; 2015. 147p. ISBN 978-94-6259-657-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van den Brink GR; copromotor(s): Muncan V, Heijmans J)
Rosekrans SL, Baan B , Muncan V , van den Brink GR, Esophageal development and epithelial homeostasis. AM J PHYSIOL-GASTR L 2015;309 (4):G216-G228 [PubMed]
Rosekrans SL, Heijmans J, Büller NVJA, Westerlund J , Lee AS, Muncan V , van den Brink GR, ER stress induces epithelial differentiation in the mouse oesophagus. GUT 2015;64 (2):195-202 [PubMed]
Rossen NG, Fuentes S, van der Spek MJ, Tijssen JG, Hartman JHA, Duflou A, Löwenberg M, van den Brink GR, Mathus-Vliegen EMH, de Vos WM, Zoetendal EG, D'Haens GR, Ponsioen CY, Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis. GASTROENTEROLOGY 2015;149 (1):110-118.e4 [PubMed]
Shah YM, van den Brink GR, c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer. GASTROENTEROLOGY 2015;149 (3):534-537 [PubMed]
van Lidth de Jeude JF, Vermeulen JLM, Montenegro-Miranda PS, van den Brink GR, Heijmans J, A protocol for lentiviral transduction and downstream analysis of intestinal organoids. JOVE-J VIS EXP 2015;2015 (98):e52531 [PubMed]
Voorneveld PW, Kodach LL, Jacobs RJ, van Noesel CJM, Peppelenbosch MP, Korkmaz KS, Molendijk I, Dekker E, Morreau H, van Pelt GW, Tollenaar RAEM, Mesker W, Hawinkels LJAC, Paauwe M, Verspaget HW, Geraets DT, Hommes DW, Offerhaus GJA, van den Brink GR, ten Dijke P, Hardwick JCH, The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC. BRIT J CANCER 2015;112 (1):122-130 [PubMed]
Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR, ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. CELL REP 2015;13 (3):490-494 [PubMed]
Zimberlin CD, Lancini C, Sno R, Rosekrans SL, McLean CM, Vlaming H, van den Brink GR, Bots M, Medema JP, Dannenberg JH, HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis. FASEB J 2015;29 (5):2070-2080 [PubMed]
Amos-Landgraf JM, Heijmans J, Wielenga MCB, Dunkin E, Krentz KJ, Clipson L, Ederveen AG, Groothuis PG, Mosselman S, Muncan V , Hommes DW, Shedlovsky A, Dove WF, van den Brink GR, Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones. P NATL ACAD SCI USA 2014;111 (46):16514-16519 [PubMed]
Brandse JF, Peters CP, Gecse KB, Eshuis EJ, Jansen JM, Tuynman HA, Löwenberg M, Ponsioen CY, van den Brink GR, Dʼhaens GR, Effects of infliximab retreatment after consecutive discontinuation of infliximab and adalimumab in refractory Crohn's disease. INFLAMM BOWEL DIS 2014;20 (2):251-258 [PubMed]
de Bruyn JR, van Heeckeren R, Ponsioen CY, van den Brink GR, Löwenberg M, Bredenoord AJ, Frijstein G, D'Haens GR, Vitamin D deficiency in Crohn's disease and healthy controls: a prospective case-control study in the Netherlands. J CROHNS COLITIS 2014;8 (10):1267-1273 [PubMed]
Duijvestein M. Stem cell therapy for inflammatory bowel disease. s.l.: s.n.; 2014. -p. ISBN 9789081853705 Proefschrift Universiteit Leiden, Geneeskunde. (Promotor(s): Hommes DW; copromotor(s): van den Brink GR, Roelofs H)
Heijmans J, Wielenga MCB, Rosekrans SL, van Lidth de Jeude JF, Roelofs J, Groothuis P, Ederveen A, de Jonge-Muller ESM, Biemond I, Hardwick JCH, D'Haens G, Hommes DW, Muncan V , van den Brink GR, Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer. GUT 2014;63 (2):310-316 [PubMed]
Levin AD, van den Brink GR, Selective inhibition of mucosal serotonin as treatment for IBD?. GUT 2014;63 (6):866-867 [PubMed]
Löwenberg M, Duijvis NW , Ponsioen C, van den Brink GR, Fockens P, D'Haens GRAM, Length of hospital stay and associated hospital costs with infliximab versus cyclosporine in severe ulcerative colitis. EUR J GASTROEN HEPAT 2014;26 (11):1240-1246 [PubMed]
Phesse TJ, Myant KB, Cole AM, Ridgway RA, Pearson H, Muncan V, van den Brink GR, Vousden KH, Sears R, Vassilev LT, Clarke AR, Sansom OJ, Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. CELL DEATH DIFFER 2014;21 (6):956-966 [PubMed]
Verhaar AP, Wildenberg ME, Peppelenbosch MP, Hommes DW, van den Brink GR, Repurposing miltefosine for the treatment of immune-mediated disease?. J PHARMACOL EXP THER 2014;350 (2):189-195 [PubMed]
Voorneveld PW, Kodach LL, Jacobs RJ, Liv N, Zonnevylle AC, Hoogenboom JP, Biemond I, Verspaget HW, Hommes DW, de Rooij K, van Noesel CJM, Morreau H, van Wezel T, Offerhaus GJA, van den Brink GR, Peppelenbosch MP, ten Dijke P, Hardwick JCH, Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK. GASTROENTEROLOGY 2014;147 (1):196-208.e13 [PubMed]
Wielenga MCB, van Lidth de Jeude JF, Rosekrans SL, Levin AD, Schukking M, D'Haens GRAM, Heijmans J, Jansen M, Muncan V , van den Brink GR, Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis. WORLD J GASTROENTERO 2014;20 (44):16683-16689 [PubMed]
Gecse KB, Khanna R, van den Brink GR, Ponsioen CY, Löwenberg M, Jairath V, Travis SPL, Sandborn WJ, Feagan BG, D'Haens GRAM, Biosimilars in IBD: hope or expectation?. GUT 2013;62 (6):803-807 [PubMed]
Heijmans J. A close-up of colon cancer. s.l.: s.n.; 2013. 209p. ISBN 9789090277530 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van den Brink GR, Hommes DW; copromotor(s): Muncan V)
Heijmans J, Büller NVJA, Hoff E, Dihal AA, van der Poll T, van Zoelen MAD, Bierhaus A, Biemond I, Hardwick JCH, Hommes DW, Muncan V, van den Brink GR, Rage signalling promotes intestinal tumourigenesis. ONCOGENE 2013;32 (9):1202-1206 [PubMed]
Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MCB, van de Wetering M, Ferrante M, Lee AS, Onderwater JJM, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V , van den Brink GR, ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. CELL REP 2013;3 (4):1128-1139 [PubMed]
Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PCW, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H, Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit. GASTROENTEROLOGY 2013;144 (1):134-144.e6 [PubMed]
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR, Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. CELL 2013;152 (1-2):25-38 [PubMed]
Strisciuglio C, Duijvestein M, Verhaar AP, Vos ACW, van den Brink GR, Hommes DW, Wildenberg ME, Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions. J CROHNS COLITIS 2013;7 (7):534-541 [PubMed]
van den Brink GR, Rubin DC, Foxf2: a mesenchymal regulator of intestinal adenoma development. GASTROENTEROLOGY 2013;144 (5):873-876 [PubMed]
van Dop WA, Rosekrans SL, Uhmann A, Jaks V, Offerhaus GJA, van den Bergh Weerman MA, Kasper M, Heijmans J, Hardwick JCH, Verspaget HW, Hommes DW, Toftgård R, Hahn H, van den Brink GR, Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus. GUT 2013;62 (3):348-357 [PubMed]
Verhaar AP, Wildenberg ME, Duijvestein M, Vos ACW, Peppelenbosch MP, Löwenberg M, Hommes DW, van den Brink GR, Superantigen-induced steroid resistance depends on activation of phospholipase cβ2. J IMMUNOL 2013;190 (12):6589-6595 [PubMed]
Verhaar AP, Wildenberg ME, te Velde AA, Meijer SL, Vos ACW, Duijvestein M, Peppelenbosch MP, Hommes DW, van den Brink GR, Miltefosine suppresses inflammation in a mouse model of inflammatory bowel disease. INFLAMM BOWEL DIS 2013;19 (9):1974-1982 [PubMed]
Baan B , Dihal AA, Hoff E, Bos CL, Voorneveld PW, Koelink PJ, Wildenberg ME, Muncan V , Heijmans J, Verspaget HW, Richel DJ, Hardwick JCH, Hommes DW, Peppelenbosch MP, van den Brink GR, 5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer. GUT 2012;61 (12):1708-1715 [PubMed]
Büller NVJA, Rosekrans SL, van den Brink GR. Self-renewal and Differentiation of Intestinal Stem Cells: Role of Hedgehog Pathway in: Hayat MA, editors. Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 2. Berlin: Springer; 2012., p. 95-102
Büller NVJA, Rosekrans SL, Westerlund J , van den Brink GR, Hedgehog Signaling and Maintenance of Homeostasis in the Intestinal Epithelium. PHYSIOLOGY 2012;27 (3):148-155 [PubMed]
Heijmans J, Büller NVJA, Muncan V , van den Brink GR, Rage mediated DAMP signaling in intestinal tumorigenesis. ONCOIMMUNOLOGY 2012;1 (7):1165-1166 [PubMed]
Heijmans J, Büller NV, Muncan V, van den Brink GR, Role of mast cells in colorectal cancer development, the jury is still out. BBA-MOL BASIS DIS 2012;1822 (1):9-13 [PubMed]
tee JM, Sartori da Silva MA, Rygiel AM, Muncan V , Bink R, van den Brink GR, van Tijn P, Zivkovic D, Kodach LL, Guardavaccaro D, Diks SH, Peppelenbosch MP, asb11 is a regulator of embryonic and adult regenerative myogenesis. STEM CELLS DEV 2012;21 (17):3091-3103 [PubMed]
Vos ACW, Wildenberg ME, Arijs I, Duijvestein M, Verhaar AP, de Hertogh G, Vermeire S, Rutgeerts P, van den Brink GR, Hommes DW, Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro. INFLAMM BOWEL DIS 2012;18 (3):401-408 [PubMed]
Wildenberg ME, van den Brink GR, A major advance in ex vivo intestinal organ culture. GUT 2012;61 (7):961-962 [PubMed]
Wildenberg ME, Vos ACW, Wolfkamp SCS, Duijvestein M, Verhaar AP, te Velde AA, van den Brink GR, Hommes DW, Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse. GASTROENTEROLOGY 2012;142 (7):1493-+ [PubMed]
Duijvestein M, Molendijk I, Roelofs H, Vos ACW, Verhaar AP, Reinders MEJ, Fibbe WE, Verspaget HW, van den Brink GR, Wildenberg ME, Hommes DW, Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease. CYTOTHERAPY 2011;13 (9):1066-1073 [PubMed]
Duijvestein M, Wildenberg ME, Welling MM, Hennink S, Molendijk I, van Zuylen VL, Bosse T, Vos ACW, de Jonge-Muller ESM, Roelofs H, van der Weerd L, Verspaget HW, Fibbe WE, te Velde AA, van den Brink GR, Hommes DW, Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis. STEM CELLS 2011;29 (10):1549-1558 [PubMed]
Heijmans J, Muncan V , Jacobs RJ, de Jonge-Muller ESM, Graven L, Biemond I, Ederveen AG, Groothuis PG, Mosselman S, Hardwick JC, Hommes DW, van den Brink GR, Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. PLOS ONE 2011;6 (7):e22620 [PubMed]
Kodach LL, Jacobs RJ, Voorneveld PW, Wildenberg ME, Verspaget HW, van Wezel T, Morreau H, Hommes DW, Peppelenbosch MP, van den Brink GR, Hardwick JCH, Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway. GUT 2011;60 (11):1544-1553 [PubMed]
Muncan V , Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR, Blimp1 regulates the transition of neonatal to adult intestinal epithelium. NAT COMMUN 2011;2:452 [PubMed]
van der Marel S, Comijn EM, Verspaget HW, van Deventer S, van den Brink GR, Petry H, Hommes DW, Ferreira V, Neutralizing antibodies against adeno-associated viruses in inflammatory bowel disease patients: implications for gene therapy. INFLAMM BOWEL DIS 2011;17 (12):2436-2442 [PubMed]
van Dop WA. Hedgehog signaling in homeostasis of the gastrointestinal tract. s.l.: s.n.; 2011. 178p. ISBN 9789090261508 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Boeckxstaens GE; copromotor(s): van den Brink GR)
Vos ACW. Towards therapeutic disease control in inflammatory bowel diseases. s.l.: s.n.; 2011. -p. ISBN 9789081774000 Proefschrift Universiteit Leiden, LUMC. (Promotor(s): Hommes DW; copromotor(s): van den Brink GR, Wildenberg ME)
Vos ACW, Wildenberg ME, Duijvestein M, Verhaar AP, van den Brink GR, Hommes DW, Anti-tumor necrosis factor-α antibodies induce regulatory macrophages in an Fc region-dependent manner. GASTROENTEROLOGY 2011;140 (1):221-230 [PubMed]
Wildenberg ME, van den Brink GR, FXR activation inhibits inflammation and preserves the intestinal barrier in IBD. GUT 2011;60 (4):432-433 [PubMed]
Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, van den Brink GR, Muncan V , Clevers H, Clarke AR, Sicinski P, Sansom OJ, Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. CANCER RES 2010;70 (20):8149-8158 [PubMed]
Duijvestein M, Vos ACW, Roelofs H, Wildenberg ME, Wendrich BB, Verspaget HW, Kooy-Winkelaar EMC, Koning F, Zwaginga JJ, Fidder HH, Verhaar AP, Fibbe WE, van den Brink GR, Hommes DW, Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. GUT 2010;59 (12):1662-1669 [PubMed]
Heijmans J, van den Brink GR, Morphogens and the parietal cell: shaping up acid secretion. GASTROENTEROLOGY 2010;139 (6):1830-1833 [PubMed]
Kodach LL, Jacobs RJ, Heijmans J, van Noesel CJM, Langers AMJ, Verspaget HW, Hommes DW, Offerhaus GJA, van den Brink GR, Hardwick JCH, The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer. CARCINOGENESIS 2010;31 (9):1567-1575 [PubMed]
van Dop WA, Heijmans J, Büller NVJA, Snoek SA, Rosekrans SL, Wassenberg EA, van den Bergh Weerman MA, Lanske B, Clarke AR, Winton DJ, Wijgerde M, Offerhaus GJ, Hommes DW, Hardwick JC, de Jonge WJ, Biemond I, van den Brink GR, Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine. GASTROENTEROLOGY 2010;139 (5):1665-76, 1676.e1-10 [PubMed]
van Dop WA, Marengo S, te Velde AA, Ciraolo E, Franco I, ten Kate FJ, Boeckxstaens GE, Hardwick JC, Hommes DW, Hirsch E, van den Brink GR, The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. IMMUNOL LETT 2010;131 (1):33-39 [PubMed]
van Dop WA, van den Brink GR, Sonic Hedgehog: A Link Between Inflammation, Gastric Atrophy, and Acid Suppression?. GASTROENTEROLOGY 2010;138 (2):426-429 [PubMed]
van den Berg A, van Elburg RM, Vermeij L, van Zwol A, van den Brink GR, Twisk JW, Nieuwenhuis EE, Fetter WP, Cytokine Responses in Very Low Birth Weight Infants Receiving Glutamine-enriched Enteral Nutrition. J PEDIATR GASTR NUTR 2009;48 (1):94-101 [PubMed]
van der Marel S, Duijvestein M, Hardwick JC, van den Brink GR, Veenendaal R, Hommes DW, Fidder HH, Quality of web-based information on inflammatory bowel diseases. INFLAMM BOWEL DIS 2009;15 (12):1891-1896 [PubMed]
van Dop WA, Uhmann A, Wijgerde M, Sleddens-Linkels E, Heijmans J, Offerhaus GJ, van den Bergh Weerman MA, Boeckstaens GE, Hommes DW, Hardwick JC, Hahn H, van den Brink GR, Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway. GASTROENTEROLOGY 2009;136 (7):2195-2203 [PubMed]
Vermeulen L, Medema JP, Hardwick JCH, van den Brink GR. Cancer Stem Cells in Colorectal Cancer in: Majumder S, editor. Stem Cells and Cancer. Berlin; New York: Springer; 2009., p. 233-250
Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R, Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. J PATHOL 2008;215 (4):411-420 [PubMed]
Duijvestein M, van den Brink GR, Hommes DW, Stem cells as potential novel therapeutic strategy for inflammatory bowel disease. J CROHNS COLITIS 2008;2 (2):99-106 [PubMed]
Hardwick JC, Kodach LL, Offerhaus GJ, van den Brink GR, Bone morphogenetic protein signalling in colorectal cancer. NAT REV CANCER 2008;8 (10):806-812 [PubMed]
Kodach LL, Bleuming SA, Musler AR, Peppelenbosch MP, Hommes DW, van den Brink GR, van Noesel CJM, Offerhaus GJA, Hardwick JCH, The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer. CANCER-AM CANCER SOC 2008;112 (2):300-306 [PubMed]
Kodach LL, Wiercinska E, de Miranda NFCC, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJM, Morreau H, Hommes DW, ten Dijke P, Offerhaus GJA, Hardwick JCH, The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. GASTROENTEROLOGY 2008;134 (5):1332-1341 [PubMed]
Bleuming SA. The understanding and use of morphogens in gastrointestinal disease. s.l.: s.n.; 2007. 163p. ISBN 9789053351208 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Peppelenbosch MP, Offerhaus GJA; copromotor(s): van den Brink GR)
Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, ten Kate FJ, van Deventer SJH, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR, Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. CANCER RES 2007;67 (17):8149-8155 [PubMed]
Kodach LL, Bleuming SA, Peppelenbosch MP, Hommes DW, van den Brink GR, Hardwick JCH, The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway. GASTROENTEROLOGY 2007;133 (4):1272-1281 [PubMed]
Lowenberg M, Verhaar AP, van den Brink GR, Hommes DW, Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression. TRENDS MOL MED 2007;13 (4):158-163 [PubMed]
van den Brink GR, Hedgehog signaling in development and homeostasis of the gastrointestinal tract. PHYSIOL REV 2007;87 (4):1343-1375 [PubMed]
van den Brink GR, Offerhaus GJ, The morphogenetic code and colon cancer development. CANCER CELL 2007;11 (2):109-117 [PubMed]
Bleuming SA, Kodach LL, Garcia Leon MJ, Richel DJ, Peppelenbosch MP, Reitsma PH, Hardwick JC, van den Brink GR, Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach. J PATHOL 2006;209 (2):190-197 [PubMed]
Bos CL, Kodach LL, van den Brink GR, Diks SH, van Santen MM, Richel DJ, Peppelenbosch MP, Hardwick JCH, Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. ONCOGENE 2006;25 (49):6447-6456 [PubMed]
van den Brink GR, Hardwick JCH, Hedgehog Wnteraction in colorectal cancer. GUT 2006;55 (7):912-914 [PubMed]
van den Brink GR, Peppelenbosch MP, Expression of hedgehog pathway components in the adult colon. GASTROENTEROLOGY 2006;130 (2):619 [PubMed]
Xu CP, Ji WM, van den Brink GR, Peppelenbosch MP, Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver. WORLD J GASTROENTERO 2006;12 (47):7621-7625 [PubMed]
Suzuki H, Minegishi Y, Nomoto Y, Ota T, Masaoka T, van den Brink GR, Hibi T, Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils. J PATHOL 2005;206 (2):186-197 [PubMed]
Bleuming SA, Peppelenbosch MP, Roberts DJ, van den Brink GR, Homeostasis of the adult colonic epithelium: a role for morphogens. SCAND J GASTROENTERO 2004;39 (2):93-98 [PubMed]
Hardwick JCH, van den Brink GR, Bleuming SA, Ballester I, van den Brande JMH, Keller JJ, Offerhaus GJA, van Deventer SJH, Peppelenbosch MP, Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. GASTROENTEROLOGY 2004;126 (1):111-121 [PubMed]
Hardwick JCH, van Santen M, van den Brink GR, van Deventer SJH, Peppelenbosch MP, DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. CARCINOGENESIS 2004;25 (7):1293-1298 [PubMed]
Nielsen CM, Williams J, van den Brink GR, Lauwers GY, Roberts DJ, Hh pathway expression in human gut tissues and in inflammatory gut diseases. LAB INVEST 2004;84 (12):1631-1642 [PubMed]
van den Brink GR, Linking pathways in colorectal cancer. NAT GENET 2004;36 (10):1038-1039 [PubMed]
van den Brink GR, Bleuming SA, Hardwick JCH, Schepman BL, Offerhaus GJ, Keller JJ, Nielsen C, Gaffield W, van Deventer SJH, Roberts DJ, Peppelenbosch MP, Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. NAT GENET 2004;36 (3):277-282 [PubMed]
Verhave M, Krasinski SD, Christian SI, van Schaik S, van den Brink GR, Doting EMH, Maas SM, Wolthers KC, Grand RJ, Montgomery RK, Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression. J PEDIATR GASTR NUTR 2004;39 (3):275-285 [PubMed]
Bonta PI, Kok MF, Bergman JJGHM, van den Brink GR, Lemkes JS, Tytgat GNJ, Fockens P, Conscious sedation for EUS of the esophagus and stomach: a double-blind, randomized, controlled trial comparing midazolam with placebo. GASTROINTEST ENDOSC 2003;57 (7):842-847 [PubMed]
de Santa Barbara P, van den Brink GR, Roberts DJ, Development and differentiation of the intestinal epithelium. CELL MOL LIFE SCI 2003;60 (7):1322-1332 [PubMed]
van den Brande JMH, Braat H, van den Brink GR, Versteeg HH, Bauer CA, Hoedemaeker I, van Montfrans C, Hommes DW, Peppelenbosch MP, van Deventer SJH, Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. GASTROENTEROLOGY 2003;124 (7):1774-1785 [PubMed]
van den Brink GR, Hardwick JCH, Nielsen C, Xu C, ten Kate FJ, Glickman J, van Deventer SJH, Roberts DJ, Peppelenbosch MP, Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. J CLIN PATHOL-MOL PA 2003;56 (3):150-155
de Santa Barbara P, van den Brink GR, Roberts DJ, Molecular etiology of gut malformations and diseases. AM J MED GENET 2002;115 (4):221-230 [PubMed]
van den Blink B, ten Hove T, van den Brink GR, Peppelenbosch MP, van Deventer SJH, From extracellular to intracellular targets, inhibiting MAP kinases in treatment of Crohn's disease. ANN NY ACAD SCI 2002;973:349-358 [PubMed]
van den Brink GR. Morphostasis of the adult gastrointestinal tract. S.l.: s.n.; 2002. 252p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Deventer SJH; copromotor(s): Peppelenbosch MP, Roberts DJ)
van den Brink GR, Hardwick JCH, Nielsen C, Xu C, ten Kate FJ, Glickman J, van Deventer SJH, Roberts DJ, Peppelenbosch MP, Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. GUT 2002;51 (5):628-633 [PubMed]
van den Brink GR, van den Boogaardt DEM, van Deventer SJH, Peppelenbosch MP, Feed a cold, starve a fever?. CLIN DIAGN LAB IMMUN 2002;9 (1):182-183 [PubMed]
Hardwick JC, van den Brink GR, Offerhaus GJ, van Deventer SJ, Peppelenbosch MP, Leptin is a growth factor for colonic epithelial cells. GASTROENTEROLOGY 2001;121 (1):79-90 [PubMed]
Hardwick JC, van den Brink GR, Offerhaus GJ, van Deventer SJ, Peppelenbosch MP, NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. ONCOGENE 2001;20 (7):819-827 [PubMed]
van den Brink GR, de Santa Barbara P, Roberts DJ, Development. Epithelial cell differentiation--a Mather of choice. SCIENCE 2001;294 (5549):2115-2116 [PubMed]
van den Brink GR, Hardwick JC, Tytgat GN, Brink MA, ten Kate FJ, van Deventer SJ, Peppelenbosch MP, Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. GASTROENTEROLOGY 2001;121 (2):317-328 [PubMed]
van den Brink GR, O'Toole T, Hardwick JC, van den Boogaardt DE, Versteeg HH, van Deventer SJ, Peppelenbosch MP, Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase. MOL CELL BIOL RES COMMUN 2000;4 (3):144-150 [PubMed]
van den Brink GR, ten Kate FJ, Ponsioen CY, Rive MM , Tytgat GN, van Deventer SJ, Peppelenbosch MP, Expression and activation of NF-kappa B in the antrum of the human stomach. J IMMUNOL 2000;164 (6):3353-3359 [PubMed]
van den Brink GR, Tytgat KM, van der Hulst RW, van der Loos CM, Einerhand AW, Büller HA, Dekker J, H pylori colocalises with MUC5AC in the human stomach. GUT 2000;46 (5):601-607 [PubMed]
Versteeg HH, Nijhuis E, van den Brink GR, Evertzen M, Pynaert GN, van Deventer SJ, Coffer PJ, Peppelenbosch MP, A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein. BIOCHEM J 2000;350 Pt 3:717-722 [PubMed]
van den Brink GR, Bloemers SM, van den Blink B, Tertoolen LG, van Deventer SJ, Peppelenbosch MP, Study of calcium signaling in non-excitable cells. MICROSC RES TECHNIQ 1999;46 (6):418-433 [PubMed]
Bergman JJ, van den Brink GR, Rauws EA, de Wit L, Obertop H, Huibregtse K, Tytgat GN, Gouma DJ, Treatment of bile duct lesions after laparoscopic cholecystectomy. GUT 1996;38 (1):141-147 [PubMed]
Key publications

Amos-Landgraf JM, Heijmans J, Wielenga MCB, Dunkin E, Krentz KJ, Clipson L, Ederveen AG, Groothuis PG, Mosselman S, Muncan V , Hommes DW, Shedlovsky A, Dove WF, van den Brink GR, Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones. P NATL ACAD SCI USA 2014;111 (46):16514-16519 [PubMed]
Büller NVJA, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JLM, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GRAM, Wildenberg ME, de Sauvage FJ, Muncan V , van den Brink GR, Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice. GASTROENTEROLOGY 2015;148 (1):170-180.e6 [PubMed]
Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MCB, van de Wetering M, Ferrante M, Lee AS, Onderwater JJM, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V , van den Brink GR, ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. CELL REP 2013;3 (4):1128-1139 [PubMed]
Wildenberg ME, Vos ACW, Wolfkamp SCS, Duijvestein M, Verhaar AP, te Velde AA, van den Brink GR, Hommes DW, Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse. GASTROENTEROLOGY 2012;142 (7):1493-+ [PubMed]
Muncan V , Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR, Blimp1 regulates the transition of neonatal to adult intestinal epithelium. NAT COMMUN 2011;2:452 [PubMed]


All Publications

Curriculum Vitae

See: http://nl.linkedin.com/pub/gijs-van-den-brink/4/897/890

Research programmes

Prof. dr. G.R. van den Brink MD PhD (Intestinal mucosal homeostasis and it's deregulation in inflammatory bowel disease and during oncogenesis)

Faculty
Prof. dr. G.R. van den Brink MD PhD
Dr. T.B.M. Hakvoort
Dr. V. Muncan

Postdocs
Dr. B. Baan
Dr. O. Karpus MSc
Dr. P.J. Koelink
P.S.M. Miranda
Dr. G.S. Tjabringa
Dr. L. Westera
Dr. M.E. Wildenberg

PhD Students
Dr. J.R. de Bruyn MD
Drs. M.C.S van der Heijden
Drs. F.M. Houttuijn Bloemendaal MD
Drs. A.D. Levin
Drs. J.F. van Lidth de Jeude MD
T. Martins Garcia
J.H.M. van der Meer
B.J. Meijer MD
M. Navis
M.M.C. Prins
W.L. Smit
C.N. Spaan
T.W. Stevens
Drs. B.F. Westendorp
A.P. Verhaar BSc

Others
S. Meisner BSc
J.L. Vermeulen BSc
Ing. E.W.M. Vogels

Prof. dr. G.R.A.M. D'Haens PhD (CHRONIC INFLAMMATORY BOWEL DISEASES)

Other research related activities
  • Membership of editorial board / Editorship, JOURNAL OF CROHNS & COLITIS
  • Membership of editorial board / Editorship, GASTROENTEROLOGY
  • Membership of editorial board / Editorship, GUT
  • Membership of medical or scientific committee, European Crohn's and Colitis Organisation (ECCO), Scientific committee
  • Membership of medical or scientific committee, United European Gastroenterology (UEG), Educational committee
  • Membership of medical or scientific committee, UEG, Course director UEG Summer School
  • Membership of medical or scientific committee, UEG, Course director UEG Young Investigator Meeting
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Medical Research BV
  • ZonMw